Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay:
- de la Mare, Jo-Anne, Sterrenberg, Jason N, Sukhthankar, Mugdha G, Chiwakata, Maynard T, Beukes, Denzil R, Blatch, Gregory L, Edkins, Adrienne L
- Authors: de la Mare, Jo-Anne , Sterrenberg, Jason N , Sukhthankar, Mugdha G , Chiwakata, Maynard T , Beukes, Denzil R , Blatch, Gregory L , Edkins, Adrienne L
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165184 , vital:41216 , DOI: 10.1186/1475-2867-13-39
- Description: The cancer stem cell (CSC) theory proposes that tumours arise from and are sustained by a subpopulation of cells with both cancer and stem cell properties. One of the key hallmarks of CSCs is the ability to grow anchorage-independently under serum-free culture conditions resulting in the formation of tumourspheres. It has further been reported that these cells are resistant to traditional chemotherapeutic agents.
- Full Text:
- Date Issued: 2013
- Authors: de la Mare, Jo-Anne , Sterrenberg, Jason N , Sukhthankar, Mugdha G , Chiwakata, Maynard T , Beukes, Denzil R , Blatch, Gregory L , Edkins, Adrienne L
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165184 , vital:41216 , DOI: 10.1186/1475-2867-13-39
- Description: The cancer stem cell (CSC) theory proposes that tumours arise from and are sustained by a subpopulation of cells with both cancer and stem cell properties. One of the key hallmarks of CSCs is the ability to grow anchorage-independently under serum-free culture conditions resulting in the formation of tumourspheres. It has further been reported that these cells are resistant to traditional chemotherapeutic agents.
- Full Text:
- Date Issued: 2013
Halogenated oxindole and indoles from the South African marine ascidian Distaplia skoogi:
- Bromley, Candice L, Parker-Nance, Shirley, de la Mare, Jo-Anne, Edkins, Adrienne L, Beukes, Denzil R, Davies-Coleman, Michael T
- Authors: Bromley, Candice L , Parker-Nance, Shirley , de la Mare, Jo-Anne , Edkins, Adrienne L , Beukes, Denzil R , Davies-Coleman, Michael T
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/164918 , vital:41184
- Description: The known 3,6-dibromoindole (1), 6-bromo-3-chloroindole (2) and 6-bromo-2-oxindole (3) were isolated from the marine ascidian (sea squirt) Distapia skoogi collected from Algoa Bay, South Africa. Standard spectroscopic techniques were used to elucidate the structures of 1-3. All three compounds were found to be moderately cytotoxic to metastatic MDA-MB-231 breast cancer cells.
- Full Text:
- Date Issued: 2013
- Authors: Bromley, Candice L , Parker-Nance, Shirley , de la Mare, Jo-Anne , Edkins, Adrienne L , Beukes, Denzil R , Davies-Coleman, Michael T
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/164918 , vital:41184
- Description: The known 3,6-dibromoindole (1), 6-bromo-3-chloroindole (2) and 6-bromo-2-oxindole (3) were isolated from the marine ascidian (sea squirt) Distapia skoogi collected from Algoa Bay, South Africa. Standard spectroscopic techniques were used to elucidate the structures of 1-3. All three compounds were found to be moderately cytotoxic to metastatic MDA-MB-231 breast cancer cells.
- Full Text:
- Date Issued: 2013
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