Preferences of resettled refugees on pictograms describing common symptoms of illness:
- Bellamy, Kim, Dowse, Roslind, Ostini, Remo, Martini, Nataly, Kairuz, Therese
- Authors: Bellamy, Kim , Dowse, Roslind , Ostini, Remo , Martini, Nataly , Kairuz, Therese
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/${Handle} , vital:40086 , https://0-doi.org.wam.seals.ac.za/10.1007/s10903-019-00908-3
- Description: Illustrated health resources are useful for people who have limited English linguistic ability. The aim was to compare the preferences of resettled refugees from Africa and non-African countries, on pictograms describing common symptoms of illness. Data were collected in two cities in Queensland, Australia. Participants indicated their preference for three types of pictograms depicting seven symptoms. Pictogram sources included the International Pharmaceutical Federation, royaltyfree stock images, and pictograms designed in South Africa.
- Full Text:
- Date Issued: 2020
- Authors: Bellamy, Kim , Dowse, Roslind , Ostini, Remo , Martini, Nataly , Kairuz, Therese
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/${Handle} , vital:40086 , https://0-doi.org.wam.seals.ac.za/10.1007/s10903-019-00908-3
- Description: Illustrated health resources are useful for people who have limited English linguistic ability. The aim was to compare the preferences of resettled refugees from Africa and non-African countries, on pictograms describing common symptoms of illness. Data were collected in two cities in Queensland, Australia. Participants indicated their preference for three types of pictograms depicting seven symptoms. Pictogram sources included the International Pharmaceutical Federation, royaltyfree stock images, and pictograms designed in South Africa.
- Full Text:
- Date Issued: 2020
The impact of illustrated side effect information on understanding and sustained retention of antiretroviral side effect knowledge:
- Browne, Sara H, Barford, Kirsty-Lee, Ramela, Thato, Dowse, Roslind
- Authors: Browne, Sara H , Barford, Kirsty-Lee , Ramela, Thato , Dowse, Roslind
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156341 , vital:39980 , https://doi.org/10.1016/j.sapharm.2018.05.012
- Description: Prompt management of side effects is critical to supporting adherence to antiretroviral (ARV) medication. This study examines the impact of presenting side effect information using simple text combined with pictograms on sustained knowledge of ARV side effects over three months. Previously designed side effect pictograms, combined with simple text, were incorporated into a side effects panel within an ARV information leaflet. In a randomised controlled study, 116 limited literacy HIV patients taking ARVs were randomly allocated to either control (standard care) or intervention groups (standard care plus illustrated information). Side effect knowledge was assessed at baseline, and intervention patients received the illustrated leaflet. Knowledge was re-tested at one and three months. Interpretation of side effect pictograms was evaluated at one month.
- Full Text:
- Date Issued: 2019
- Authors: Browne, Sara H , Barford, Kirsty-Lee , Ramela, Thato , Dowse, Roslind
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156341 , vital:39980 , https://doi.org/10.1016/j.sapharm.2018.05.012
- Description: Prompt management of side effects is critical to supporting adherence to antiretroviral (ARV) medication. This study examines the impact of presenting side effect information using simple text combined with pictograms on sustained knowledge of ARV side effects over three months. Previously designed side effect pictograms, combined with simple text, were incorporated into a side effects panel within an ARV information leaflet. In a randomised controlled study, 116 limited literacy HIV patients taking ARVs were randomly allocated to either control (standard care) or intervention groups (standard care plus illustrated information). Side effect knowledge was assessed at baseline, and intervention patients received the illustrated leaflet. Knowledge was re-tested at one and three months. Interpretation of side effect pictograms was evaluated at one month.
- Full Text:
- Date Issued: 2019
Acceptance of ambulatory blood pressure monitoring in a semi-rural population in South Africa:
- Chiwanza, Farisai, Irwin, Yoland, Dowse, Roslind
- Authors: Chiwanza, Farisai , Irwin, Yoland , Dowse, Roslind
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157072 , vital:40084 , DOI: https://doi.org/10.4102/hsag.v25i0.1336
- Description: Ambulatory blood pressure monitoring is a valuable tool that helps in providing an insight into the diagnosis and management of hypertension; however, no evidence exists of its acceptance in the diverse South African population. We assessed the acceptance of an ambulatory blood pressure monitor in patients attending public sector primary health care (PHC) clinics. Five PHC clinics in the Makana subdistrict in the Eastern Cape.
- Full Text:
- Date Issued: 2020
- Authors: Chiwanza, Farisai , Irwin, Yoland , Dowse, Roslind
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157072 , vital:40084 , DOI: https://doi.org/10.4102/hsag.v25i0.1336
- Description: Ambulatory blood pressure monitoring is a valuable tool that helps in providing an insight into the diagnosis and management of hypertension; however, no evidence exists of its acceptance in the diverse South African population. We assessed the acceptance of an ambulatory blood pressure monitor in patients attending public sector primary health care (PHC) clinics. Five PHC clinics in the Makana subdistrict in the Eastern Cape.
- Full Text:
- Date Issued: 2020
Biopharmaceutics of phenylpropanolamine
- Authors: Dowse, Roslind
- Date: 1984
- Subjects: Biopharmaceutics Pharmacokinetics Phenylpropanolamine Pharmacology High performance liquid chromatography
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3818 , http://hdl.handle.net/10962/d1004915
- Description: Phenylpropanolamine (PPA), a sympathomimetic amine, has been widely used over the past 40 years as a decongestant and, in much larger dosages, as an appetite suppressant. Considerable interest has recently been shown in this drug due to its increasing popularity as an over-the-counter anorectic agent. Much controversy exists concerning the unfavourable side-effects of PPA resulting from the higher doses required for appetite suppression and the potential of this drug for abuse. A literature search revealed a paucity of information concerning the determination of PPA in biological fluids and, most noticeably, on the pharmacokinetics of this drug. An original method for determining PPA in serum and urine using high performance liquid chromatography (HPLC) which has increased sensitivity over other published HPLC methods is presented here. The simplicity of the extraction from biological fluids and subsequent determination by HPLC, enables concentrations of PPA to be monitored after a single dose of the drug. This method is therefore readily applicable to bioavailability and pharmacokinetic studies. The dissolution profiles of 4 sustained-release formulations of PPA were determined in a modified USP rotating paddle apparatus and the samples analysed using HPLC. A mathematical equation was applied to these data which are expressed in terms of dissolution parameters. Oral test dosage forms and solutions of PPA were investigated in bioavailability trials using the developed HPLC method to analyse the urine and serum samples. Linear one body compartment kinetics were assumed and the WagnerNelson method used to transform in vivo serum data to absorption plots which were then fitted to the well known Weibull equation. In order to more appropriately characterize the kinetic processes of absorption, distribution and elimination, a more complex model was utilized which involved numerical integration of a series of differential equations. The data were fitted to these models using nonlinear regression techniques. The pharmacokinetics of PPA are shown to exhibit some evidence of nonlinearity. The absorption of the drug appears to be di scontinuous and PPA seems to favour a two body compartment model.
- Full Text:
- Date Issued: 1984
- Authors: Dowse, Roslind
- Date: 1984
- Subjects: Biopharmaceutics Pharmacokinetics Phenylpropanolamine Pharmacology High performance liquid chromatography
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3818 , http://hdl.handle.net/10962/d1004915
- Description: Phenylpropanolamine (PPA), a sympathomimetic amine, has been widely used over the past 40 years as a decongestant and, in much larger dosages, as an appetite suppressant. Considerable interest has recently been shown in this drug due to its increasing popularity as an over-the-counter anorectic agent. Much controversy exists concerning the unfavourable side-effects of PPA resulting from the higher doses required for appetite suppression and the potential of this drug for abuse. A literature search revealed a paucity of information concerning the determination of PPA in biological fluids and, most noticeably, on the pharmacokinetics of this drug. An original method for determining PPA in serum and urine using high performance liquid chromatography (HPLC) which has increased sensitivity over other published HPLC methods is presented here. The simplicity of the extraction from biological fluids and subsequent determination by HPLC, enables concentrations of PPA to be monitored after a single dose of the drug. This method is therefore readily applicable to bioavailability and pharmacokinetic studies. The dissolution profiles of 4 sustained-release formulations of PPA were determined in a modified USP rotating paddle apparatus and the samples analysed using HPLC. A mathematical equation was applied to these data which are expressed in terms of dissolution parameters. Oral test dosage forms and solutions of PPA were investigated in bioavailability trials using the developed HPLC method to analyse the urine and serum samples. Linear one body compartment kinetics were assumed and the WagnerNelson method used to transform in vivo serum data to absorption plots which were then fitted to the well known Weibull equation. In order to more appropriately characterize the kinetic processes of absorption, distribution and elimination, a more complex model was utilized which involved numerical integration of a series of differential equations. The data were fitted to these models using nonlinear regression techniques. The pharmacokinetics of PPA are shown to exhibit some evidence of nonlinearity. The absorption of the drug appears to be di scontinuous and PPA seems to favour a two body compartment model.
- Full Text:
- Date Issued: 1984
Determination of phenylpropanolamine in serum and urine by high performance liquid chromatography
- Dowse, Roslind, Haigh, John M, Kanfer, Isadore
- Authors: Dowse, Roslind , Haigh, John M , Kanfer, Isadore
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6361 , http://hdl.handle.net/10962/d1006056
- Description: A high-performance liquid chromatographic analysis of phenylpropanolamine in human serum and urine without prior derivatization is presented. Using direct UV detection the method is sufficiently sensitive to detect 25 ng of drug/ml of serum or urine; the coefficients of variation at 25 ng/ml and 500 ng/ml were 5.16 and 2.12, respectively, in serum. The method involves serum and urine extraction at a basic pH with chloroform, a single back-extraction, and chromatography on a reverse-phase column. Serum and urine data following administration of a single 150-mg sustained-release tablet of phenylpropanolamine hydrochloride in 6 healthy volunteers demonstrates the suitability of the analytical method.
- Full Text:
- Date Issued: 1983
- Authors: Dowse, Roslind , Haigh, John M , Kanfer, Isadore
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6361 , http://hdl.handle.net/10962/d1006056
- Description: A high-performance liquid chromatographic analysis of phenylpropanolamine in human serum and urine without prior derivatization is presented. Using direct UV detection the method is sufficiently sensitive to detect 25 ng of drug/ml of serum or urine; the coefficients of variation at 25 ng/ml and 500 ng/ml were 5.16 and 2.12, respectively, in serum. The method involves serum and urine extraction at a basic pH with chloroform, a single back-extraction, and chromatography on a reverse-phase column. Serum and urine data following administration of a single 150-mg sustained-release tablet of phenylpropanolamine hydrochloride in 6 healthy volunteers demonstrates the suitability of the analytical method.
- Full Text:
- Date Issued: 1983
The limitations of current health literacy measures for use in developing countries:
- Authors: Dowse, Roslind
- Date: 2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156607 , vital:40030 , DOI: 10.1080/17538068.2016.1147742
- Description: Health literacy measures have largely emanated from developed countries, reflecting the characteristics of their economies, populations, and health systems. In contrast, it is disconcerting that health literacy appears to be so under-researched in developing countries (DCs), despite the likelihood of inadequate health literacy being endemic. In this commentary, I highlight some challenges when using existing health literacy measures in DCs and conclude with a summary of considerations when using/developing a tool for these populations.
- Full Text:
- Date Issued: 2016
- Authors: Dowse, Roslind
- Date: 2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156607 , vital:40030 , DOI: 10.1080/17538068.2016.1147742
- Description: Health literacy measures have largely emanated from developed countries, reflecting the characteristics of their economies, populations, and health systems. In contrast, it is disconcerting that health literacy appears to be so under-researched in developing countries (DCs), despite the likelihood of inadequate health literacy being endemic. In this commentary, I highlight some challenges when using existing health literacy measures in DCs and conclude with a summary of considerations when using/developing a tool for these populations.
- Full Text:
- Date Issued: 2016
Simple, illustrated medicines information improves ARV knowledge and patient self-efficacy in limited literacy South African HIV patients:
- Dowse, Roslind, Barford, Kirsty-Lee, Browne, Sara H
- Authors: Dowse, Roslind , Barford, Kirsty-Lee , Browne, Sara H
- Date: 2014
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156698 , vital:40039 , DOI: 10.1080/09540121.2014.931559
- Description: Few studies have investigated antiretroviral (ARV) knowledge and self-efficacy in limited literacy patients. Using a randomized controlled study design, we investigated the influence of a simple pre-tested patient information leaflet (PIL) containing both text and illustrations on HIV- and ARV-related knowledge and on self-efficacy over six months in a limited literacy African population. The recruited patients were randomly allocated to either control (standard care) or intervention group (standard care plus illustrated PIL). HIV and medicines-related knowledge was evaluated with a 22-question test at baseline, one, three, and six months. Self-efficacy was assessed using a modified version of the HIV Treatment Adherence Self-Efficacy Scale.
- Full Text:
- Date Issued: 2014
- Authors: Dowse, Roslind , Barford, Kirsty-Lee , Browne, Sara H
- Date: 2014
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156698 , vital:40039 , DOI: 10.1080/09540121.2014.931559
- Description: Few studies have investigated antiretroviral (ARV) knowledge and self-efficacy in limited literacy patients. Using a randomized controlled study design, we investigated the influence of a simple pre-tested patient information leaflet (PIL) containing both text and illustrations on HIV- and ARV-related knowledge and on self-efficacy over six months in a limited literacy African population. The recruited patients were randomly allocated to either control (standard care) or intervention group (standard care plus illustrated PIL). HIV and medicines-related knowledge was evaluated with a 22-question test at baseline, one, three, and six months. Self-efficacy was assessed using a modified version of the HIV Treatment Adherence Self-Efficacy Scale.
- Full Text:
- Date Issued: 2014
The evaluation of pharmaceutical pictograms in a low-literate South African population
- Dowse, Roslind, Ehlers, Martina S
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 2001
- Language: English
- Type: Article
- Identifier: vital:6362 , http://hdl.handle.net/10962/d1006058
- Description: An inability to read and understand written medication instructions may be a major contributory factor to non-compliance in certain patient populations, particularly in countries with a high illiteracy rate such as South Africa. Twenty three pictograms from the USP-DI and a corresponding set of 23 locally developed, culturally sensitive pictograms for conveying medication instructions were evaluated in 46 Xhosa respondents who had attended school for a maximum of 7 years. Respondents were tested for their interpretation of all 46 pictograms at the first interview and again 3 weeks later. The correct meaning of each pictogram was explained at the end of the first interview. Preference for either the Local or USP pictograms was determined. At the follow-up interview, 20 of the Local pictograms complied with the ANSI criterion of ≥85% comprehension, compared with 11 of the USP pictograms. Respondents indicated an overwhelming preference for the Local pictograms.
- Full Text:
- Date Issued: 2001
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 2001
- Language: English
- Type: Article
- Identifier: vital:6362 , http://hdl.handle.net/10962/d1006058
- Description: An inability to read and understand written medication instructions may be a major contributory factor to non-compliance in certain patient populations, particularly in countries with a high illiteracy rate such as South Africa. Twenty three pictograms from the USP-DI and a corresponding set of 23 locally developed, culturally sensitive pictograms for conveying medication instructions were evaluated in 46 Xhosa respondents who had attended school for a maximum of 7 years. Respondents were tested for their interpretation of all 46 pictograms at the first interview and again 3 weeks later. The correct meaning of each pictogram was explained at the end of the first interview. Preference for either the Local or USP pictograms was determined. At the follow-up interview, 20 of the Local pictograms complied with the ANSI criterion of ≥85% comprehension, compared with 11 of the USP pictograms. Respondents indicated an overwhelming preference for the Local pictograms.
- Full Text:
- Date Issued: 2001
Outpatient compliance with theophylline and phenytoin therapy:
- Dowse, Roslind, Futter, William T
- Authors: Dowse, Roslind , Futter, William T
- Date: 1991
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157059 , vital:40083 , https://europepmc.org/article/med/1745939
- Description: Poor compliance with prescribed medication is a significant problem in chronic disease states and is often responsible for the apparent failure of therapy. The determinants and extent of non-compliance are commonly incorrectly perceived by doctors. During routine therapeutic drug monitoring of epileptic and asthmatic outpatients at a local day hospital, non-compliance was identified as a significant problem. A compliance study was conducted on 80 epileptic and asthmatic patients to determine the nature and extent of this problem. Non-compliance was measured using four different methods, which were then compared using chi 2 tests.
- Full Text:
- Date Issued: 1991
- Authors: Dowse, Roslind , Futter, William T
- Date: 1991
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157059 , vital:40083 , https://europepmc.org/article/med/1745939
- Description: Poor compliance with prescribed medication is a significant problem in chronic disease states and is often responsible for the apparent failure of therapy. The determinants and extent of non-compliance are commonly incorrectly perceived by doctors. During routine therapeutic drug monitoring of epileptic and asthmatic outpatients at a local day hospital, non-compliance was identified as a significant problem. A compliance study was conducted on 80 epileptic and asthmatic patients to determine the nature and extent of this problem. Non-compliance was measured using four different methods, which were then compared using chi 2 tests.
- Full Text:
- Date Issued: 1991
The influence of education on the interpretation of pharmaceutical pictograms for communicating medicine instructions:
- Dowse, Roslind, Ehlers, Martina S
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 2003
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157014 , vital:40079 , DOI 10.1211/002235702810
- Description: To assess the influence of formal education on the interpretation of pharmaceutical pictograms.
- Full Text:
- Date Issued: 2003
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 2003
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157014 , vital:40079 , DOI 10.1211/002235702810
- Description: To assess the influence of formal education on the interpretation of pharmaceutical pictograms.
- Full Text:
- Date Issued: 2003
Applicability of the REALM health literacy test to an English second-language South African population:
- Dowse, Roslind, Lecoko, Motlalepule L E, Ehlers, Martina S
- Authors: Dowse, Roslind , Lecoko, Motlalepule L E , Ehlers, Martina S
- Date: 2010
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156798 , vital:40051 , https://doi.org/10.1007/s11096-010-9392-y
- Description: Objective and setting. To investigate health literacy in an English second language population using the REALM test, to evaluate its appropriateness and to compare health literacy between four different education categories. Setting Primary healthcare clinics and participant homes in Grahamstown, South Africa.
- Full Text:
- Date Issued: 2010
- Authors: Dowse, Roslind , Lecoko, Motlalepule L E , Ehlers, Martina S
- Date: 2010
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156798 , vital:40051 , https://doi.org/10.1007/s11096-010-9392-y
- Description: Objective and setting. To investigate health literacy in an English second language population using the REALM test, to evaluate its appropriateness and to compare health literacy between four different education categories. Setting Primary healthcare clinics and participant homes in Grahamstown, South Africa.
- Full Text:
- Date Issued: 2010
Reflecting on patient-centred care in pharmacy through an illness narrative:
- Authors: Dowse, Roslind
- Date: 2015
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156687 , vital:40038 , https://0-doi.org.wam.seals.ac.za/10.1007/s11096-015-0104-5
- Description: Patient-centred care (PCC) is rapidly adopting a central position in discussions on the quality of healthcare, with patient-centredness deemed essential to transforming the healthcare system. PCC speaks to the quality of patient-provider relationships and has been defined as an approach to providing care that is respectful of and responsive to individual patient preferences, needs, and values, while ensuring that patient values guide all clinical decisions. However its place within pharmacy practice is unclear and is as yet undefined, particularly in relation to pharmaceutical care. Through my personal illness narrative, I briefly explore the visibility and evidence of PCC in the pharmacy literature as well as from personal experience of pharmacy care, and find it lacking. I conclude that an integrated, seamless understanding of PCC and the use of shared language within the health professions is essential in successful teamwork with both the patient and with other health professions.
- Full Text:
- Date Issued: 2015
- Authors: Dowse, Roslind
- Date: 2015
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156687 , vital:40038 , https://0-doi.org.wam.seals.ac.za/10.1007/s11096-015-0104-5
- Description: Patient-centred care (PCC) is rapidly adopting a central position in discussions on the quality of healthcare, with patient-centredness deemed essential to transforming the healthcare system. PCC speaks to the quality of patient-provider relationships and has been defined as an approach to providing care that is respectful of and responsive to individual patient preferences, needs, and values, while ensuring that patient values guide all clinical decisions. However its place within pharmacy practice is unclear and is as yet undefined, particularly in relation to pharmaceutical care. Through my personal illness narrative, I briefly explore the visibility and evidence of PCC in the pharmacy literature as well as from personal experience of pharmacy care, and find it lacking. I conclude that an integrated, seamless understanding of PCC and the use of shared language within the health professions is essential in successful teamwork with both the patient and with other health professions.
- Full Text:
- Date Issued: 2015
Designing and reporting pictogram research: problems, pitfalls and lessons learnt
- Authors: Dowse, Roslind
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157083 , vital:40085 , https://doi.org/10.1016/j.sapharm.2020.08.013
- Description: Research describing the design, evaluation or use of pictograms for various health-related applications is receiving increasing attention in the literature. However, recent reviews of this body of literature have commented adversely on the overall quality of the research, highlighting problems with the pictogram design process, as well as calling for improvement in both the methodology and reporting of all aspects of designing, developing, modifying, evaluating and applying pictograms in practice. The heterogeneity in study design, as well as in the interventions and outcomes measured, prevents overall conclusions being drawn about the effectiveness of pictograms on comprehension and medicine-taking behaviour such as adherence and self-care. The reporting of such research should provide adequate detail to enable reproducibility and replicability of the research. This article offers guidance in designing and reporting pictogram-based research, highlighting areas that are often problematic or inadequately addressed.
- Full Text:
- Date Issued: 2020
- Authors: Dowse, Roslind
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157083 , vital:40085 , https://doi.org/10.1016/j.sapharm.2020.08.013
- Description: Research describing the design, evaluation or use of pictograms for various health-related applications is receiving increasing attention in the literature. However, recent reviews of this body of literature have commented adversely on the overall quality of the research, highlighting problems with the pictogram design process, as well as calling for improvement in both the methodology and reporting of all aspects of designing, developing, modifying, evaluating and applying pictograms in practice. The heterogeneity in study design, as well as in the interventions and outcomes measured, prevents overall conclusions being drawn about the effectiveness of pictograms on comprehension and medicine-taking behaviour such as adherence and self-care. The reporting of such research should provide adequate detail to enable reproducibility and replicability of the research. This article offers guidance in designing and reporting pictogram-based research, highlighting areas that are often problematic or inadequately addressed.
- Full Text:
- Date Issued: 2020
Using pictograms in a patient information leaflet to communicate antiretroviral medicines information to HIV/AIDS patients in rural South Africa:
- Authors: Dowse, Roslind
- Date: 2009
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/156817 , vital:40053 , ISBN
- Description: The objectives were to design a simple, illustrated patient information leaflet for the antiretroviral regimen of stavudine, lamivudine and efavirenz and to evaluate its readability and acceptability in the local Xhosa population. In order to achieve this, a further objective was to design and evaluate illustrations to include in the patient information leaflet which were culturally acceptable and well interpreted. Illustrations or pictograms were designed to illustrate selected instructions appearing in the patient information leaflet and were individually tested in 30 Xhosa participants who had a maximum of 8 years of formal schooling. Results were used to improve the pictograms for inclusion in the patient information leaflet. The patient information leaflet was designed and tested in sixty Xhosa participants with varied levels of education who had stated they could read. Demographic data were collected and they were then asked to read the patient information leaflet, available in both English and isiXhosa, and a series of questions was asked to assess its comprehension and acceptability. The overall average rate of understanding was 95. Six of the 20 questions were located and understood by all participants, and only two questions resulted in less than an 85 correct response. Physical appearance and quantity of information were highly rated and all participants were enthusiastic about the inclusion of pictograms.
- Full Text:
- Date Issued: 2009
- Authors: Dowse, Roslind
- Date: 2009
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/156817 , vital:40053 , ISBN
- Description: The objectives were to design a simple, illustrated patient information leaflet for the antiretroviral regimen of stavudine, lamivudine and efavirenz and to evaluate its readability and acceptability in the local Xhosa population. In order to achieve this, a further objective was to design and evaluate illustrations to include in the patient information leaflet which were culturally acceptable and well interpreted. Illustrations or pictograms were designed to illustrate selected instructions appearing in the patient information leaflet and were individually tested in 30 Xhosa participants who had a maximum of 8 years of formal schooling. Results were used to improve the pictograms for inclusion in the patient information leaflet. The patient information leaflet was designed and tested in sixty Xhosa participants with varied levels of education who had stated they could read. Demographic data were collected and they were then asked to read the patient information leaflet, available in both English and isiXhosa, and a series of questions was asked to assess its comprehension and acceptability. The overall average rate of understanding was 95. Six of the 20 questions were located and understood by all participants, and only two questions resulted in less than an 85 correct response. Physical appearance and quantity of information were highly rated and all participants were enthusiastic about the inclusion of pictograms.
- Full Text:
- Date Issued: 2009
Developing visual images for communicating information aboutantiretroviral side effects to a low-literate population:
- Dowse, Roslind, Ramela, Thato, Barford, Kirsty-Lee, Browne, Sara H
- Authors: Dowse, Roslind , Ramela, Thato , Barford, Kirsty-Lee , Browne, Sara H
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156769 , vital:40048 , https://doi.org/10.2989/16085906.2010.530172
- Description: The side effects of antiretroviral (ARV) therapy are linked to altered quality of life and adherence. Poor adherence has also been associated with low health-literacy skills, with an uninformed patient more likely to make ARV-related decisions that compromise the efficacy of the treatment. Low literacy skills disempower patients in interactions with healthcare providers and preclude the use of existing written patient information materials, which are generally written at a high reading level. Visual images or pictograms used as a counselling tool or included in patient information leaflets have been shown to improve patients’ knowledge, particularly in low-literate groups. The objective of this study was to design visuals or pictograms illustrating various ARV side effects and to evaluate them in a low-literate South African Xhosa population. Core images were generated either from a design workshop or from posed photos or images from textbooks. The research team worked closely with a graphic artist. Initial versions of the images were discussed and assessed in group discussions, and then modified and eventually evaluated quantitatively in individual interviews with 40 participants who each had a maximum of 10 years of schooling.
- Full Text:
- Date Issued: 2011
- Authors: Dowse, Roslind , Ramela, Thato , Barford, Kirsty-Lee , Browne, Sara H
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156769 , vital:40048 , https://doi.org/10.2989/16085906.2010.530172
- Description: The side effects of antiretroviral (ARV) therapy are linked to altered quality of life and adherence. Poor adherence has also been associated with low health-literacy skills, with an uninformed patient more likely to make ARV-related decisions that compromise the efficacy of the treatment. Low literacy skills disempower patients in interactions with healthcare providers and preclude the use of existing written patient information materials, which are generally written at a high reading level. Visual images or pictograms used as a counselling tool or included in patient information leaflets have been shown to improve patients’ knowledge, particularly in low-literate groups. The objective of this study was to design visuals or pictograms illustrating various ARV side effects and to evaluate them in a low-literate South African Xhosa population. Core images were generated either from a design workshop or from posed photos or images from textbooks. The research team worked closely with a graphic artist. Initial versions of the images were discussed and assessed in group discussions, and then modified and eventually evaluated quantitatively in individual interviews with 40 participants who each had a maximum of 10 years of schooling.
- Full Text:
- Date Issued: 2011
Pictograms for conveying medicine instructions: comprehension in various South African language groups
- Dowse, Roslind, Ehlers, Martina S
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 2004
- Language: English
- Type: Article
- Identifier: vital:6354 , http://hdl.handle.net/10962/d1006038
- Description: The comprehension of medicine instructions is essential for the safe and effective use of medicines. In cases where low literacy constitutes a possible barrier to understanding written medicine information fully, the inclusion of pictograms may facilitate comprehension. Twenty-three internationally available pictograms and 23 corresponding locally developed images were evaluated in 304 low-literate respondents from eight different South African language groups. Demographic data were collected and an English literacy test was administered to those respondents who had stated that they could read English. Interviewees were shown the 46 pictograms in random order and were asked for their interpretation. Preference for either the international or local version was assessed. Correct interpretation of individual pictograms ranged from 14% to 97%. Images which had been developed locally were more successful in eliciting correct interpretations than those obtained from an international source (USP pictograms). Only 2 of the 23 USP pictograms achieved the 85% criterion of the American National Standards Institute compared with 12 of 23 locally developed counterparts. Local pictograms were preferred over the American ones in all cases. Standard of education had a significant influence on interpretation, whereas no significant differences in interpretation could be attributed to cultural diversity between the African language groups. Almost all respondents (98%) reacted positively to the idea of having pictograms on their medicine labels. The success of the local pictograms highlighted the value of a rigorous and consultative design and test process. Results from one African language group can reliably be extrapolated to other groups in South Africa.
- Full Text:
- Date Issued: 2004
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 2004
- Language: English
- Type: Article
- Identifier: vital:6354 , http://hdl.handle.net/10962/d1006038
- Description: The comprehension of medicine instructions is essential for the safe and effective use of medicines. In cases where low literacy constitutes a possible barrier to understanding written medicine information fully, the inclusion of pictograms may facilitate comprehension. Twenty-three internationally available pictograms and 23 corresponding locally developed images were evaluated in 304 low-literate respondents from eight different South African language groups. Demographic data were collected and an English literacy test was administered to those respondents who had stated that they could read English. Interviewees were shown the 46 pictograms in random order and were asked for their interpretation. Preference for either the international or local version was assessed. Correct interpretation of individual pictograms ranged from 14% to 97%. Images which had been developed locally were more successful in eliciting correct interpretations than those obtained from an international source (USP pictograms). Only 2 of the 23 USP pictograms achieved the 85% criterion of the American National Standards Institute compared with 12 of 23 locally developed counterparts. Local pictograms were preferred over the American ones in all cases. Standard of education had a significant influence on interpretation, whereas no significant differences in interpretation could be attributed to cultural diversity between the African language groups. Almost all respondents (98%) reacted positively to the idea of having pictograms on their medicine labels. The success of the local pictograms highlighted the value of a rigorous and consultative design and test process. Results from one African language group can reliably be extrapolated to other groups in South Africa.
- Full Text:
- Date Issued: 2004
Medicine labels incorporating pictograms: do they influence understanding and adherence?
- Dowse, Roslind, Ehlers, Martina S
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6359 , http://hdl.handle.net/10962/d1006051
- Description: The objective was to determine the influence of medicine labels incorporating pictograms on the understanding of instructions and on adherence. Eighty-seven Xhosa participants attending an outpatient clinic who had been prescribed a short course of antibiotics were randomly allocated to either a control group (41 participants given text-only labels), or an experimental group (46 participants given text + pictogram labels). All participants had a maximum of 10 years of formal schooling. Follow-up home visits were conducted after 3–5 days to assess understanding of instructions and to evaluate adherence. A high adherence of greater than 90% was found for 54% of the experimental group, compared with only 2% of the control group. Average percentages for understanding in the control and experimental groups were 70 and 95%, respectively, and average adherence was 72 and 90%, respectively. The presence of pictograms was found to contribute positively to both understanding of instructions and adherence.
- Full Text:
- Date Issued: 2005
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6359 , http://hdl.handle.net/10962/d1006051
- Description: The objective was to determine the influence of medicine labels incorporating pictograms on the understanding of instructions and on adherence. Eighty-seven Xhosa participants attending an outpatient clinic who had been prescribed a short course of antibiotics were randomly allocated to either a control group (41 participants given text-only labels), or an experimental group (46 participants given text + pictogram labels). All participants had a maximum of 10 years of formal schooling. Follow-up home visits were conducted after 3–5 days to assess understanding of instructions and to evaluate adherence. A high adherence of greater than 90% was found for 54% of the experimental group, compared with only 2% of the control group. Average percentages for understanding in the control and experimental groups were 70 and 95%, respectively, and average adherence was 72 and 90%, respectively. The presence of pictograms was found to contribute positively to both understanding of instructions and adherence.
- Full Text:
- Date Issued: 2005
In vitro-in vivo evaluation of a sustained release phenylpropanolamine oral dosage form
- Dowse, Roslind, Haigh, John M, Kanfer, Isadore
- Authors: Dowse, Roslind , Haigh, John M , Kanfer, Isadore
- Date: 1982
- Language: English
- Type: Article
- Identifier: vital:6360 , http://hdl.handle.net/10962/d1006052
- Description: There is increasing interest in measuring pharmacokinetic parameters of phenylpropanolamine (PPA), a sympathomimetic amine used in over-the-counter nasal decongestants and anorectic formulations. A high pressure liquid chromatographic (HPLC) procedure was developed to enable direct ultraviolet detection of PPA, after extraction from serum and urine, without prior derivatization of the drug. This method was used to assay samples obtained from a bioavailability study of BUBtained-releasePPA tablets. The mean serum and urine profiles obtained are presented. The sustained-release tablets were subjected to dissolution testing utilizing the United States Pharmacopoeia (USP XIX) rotating basket method. An internal standard was incorporated into the dissolution fluid to enable direct analysis of the samples by HPLC. A comparison of three different dissolution fluid regimens was carried out to determine if release of the drug was affected by the change in pH of the medium and to select the most convenient method for the final dissolution studies. Some preliminary observations relating to correlations between rate of drug release from the sustained-release dosage form and percent drug absorbed are presented.
- Full Text:
- Date Issued: 1982
- Authors: Dowse, Roslind , Haigh, John M , Kanfer, Isadore
- Date: 1982
- Language: English
- Type: Article
- Identifier: vital:6360 , http://hdl.handle.net/10962/d1006052
- Description: There is increasing interest in measuring pharmacokinetic parameters of phenylpropanolamine (PPA), a sympathomimetic amine used in over-the-counter nasal decongestants and anorectic formulations. A high pressure liquid chromatographic (HPLC) procedure was developed to enable direct ultraviolet detection of PPA, after extraction from serum and urine, without prior derivatization of the drug. This method was used to assay samples obtained from a bioavailability study of BUBtained-releasePPA tablets. The mean serum and urine profiles obtained are presented. The sustained-release tablets were subjected to dissolution testing utilizing the United States Pharmacopoeia (USP XIX) rotating basket method. An internal standard was incorporated into the dissolution fluid to enable direct analysis of the samples by HPLC. A comparison of three different dissolution fluid regimens was carried out to determine if release of the drug was affected by the change in pH of the medium and to select the most convenient method for the final dissolution studies. Some preliminary observations relating to correlations between rate of drug release from the sustained-release dosage form and percent drug absorbed are presented.
- Full Text:
- Date Issued: 1982
Pharmaceutical Pictograms: Part 1: Communicating Medicine Information to the Low-literate Patient
- Dowse, Roslind, Ehlers, Martina S
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 2003
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157026 , vital:40080
- Description: To assess the influence of formal education on the interpretation of pharmaceutical pictograms.
- Full Text:
- Date Issued: 2003
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 2003
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157026 , vital:40080
- Description: To assess the influence of formal education on the interpretation of pharmaceutical pictograms.
- Full Text:
- Date Issued: 2003
Using visuals to communicate medicine information to patients with low literacy:
- Authors: Dowse, Roslind
- Date: 2004
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156958 , vital:40073 , https://journals.sagepub.com/doi/pdf/10.1177/104515950401500106
- Description: The patient was adamant that she had taken her medicine as instructed, pointing to the visual (Visual 1) illustrating the instructions to endorse this. Via an interpreter, she communicated that she took her tablet three times during the day and once at night (which was correct), but only on those days when the sun was shining (not on cloudy days) and the moon was visible (depending on both cloud cover and phases of the moon).
- Full Text:
- Date Issued: 2004
- Authors: Dowse, Roslind
- Date: 2004
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156958 , vital:40073 , https://journals.sagepub.com/doi/pdf/10.1177/104515950401500106
- Description: The patient was adamant that she had taken her medicine as instructed, pointing to the visual (Visual 1) illustrating the instructions to endorse this. Via an interpreter, she communicated that she took her tablet three times during the day and once at night (which was correct), but only on those days when the sun was shining (not on cloudy days) and the moon was visible (depending on both cloud cover and phases of the moon).
- Full Text:
- Date Issued: 2004