Are CardioVascular Diseases a Cause For Concern in People of African Ancestry?
- Nkeh-Chungag, Benedicta Ngwenchi
- Authors: Nkeh-Chungag, Benedicta Ngwenchi
- Date: 2022-00
- Subjects: Cardiovascular system--Diseases--Treatment
- Language: English
- Type: Inaugural Lecture , text
- Identifier: http://hdl.handle.net/11260/8030 , vital:59356
- Description: Professor Benedicta Ngwenchi Nkeh-Chungag’s BIO Professor Benedicta Ngwenchi Nkeh-Chungag is a Full Professor of Physiology and Dean of the Faculty of Natural Sciences, Walter Sisulu University. Professor Nkeh-Chungag is an NRF rated researcher, a scholar of the Organization for Women in Science for the Developing World (OWSD), a Fellow of the International Hypertension Society, Deputy President and co-founder of the newly established Childhood Hypertension Consortium of South Africa, Deputy Chairperson of the South African National Committee for International Union for Physiological Sciences (ICSU-IUPS), Chairperson of the Cardiometabolic Research Niche Area – WSU and Chairperson of the Animal Research Ethic Committee. She oversees the Carrier Orientation and International Mentoring Program run by Harness Ideas Association (HIDAS).Professor Nkeh-Chungag has published extensively in the of cardiovascular research covering epidemiology and African medicinal plants. She has served as an Associate Editor for the journal Frontiers in Public Health and is on the editorial board of two journals, Bioinformatics and Clinical Interventions in Aging. She is a member of several knowledge bodies including the International Hypertension Society.As an accomplished and passionate scholar, Professor Nkeh-Chungag enjoys both national and international recognition in her field of research. Her focus on the risk for cardiovascular diseases in children of African ancestry has attracted interest and funding from both national and international organizations. Her research findings have been showcased at many scientific fora including as keynote addresses. Professor Nkeh-Chungag is married to Dr Anye Chungag and they are blessed with four boys. , Inaugural Lecture (Prefessorial) -- Faculty of Natural Sciences, 2022
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- Date Issued: 2022-00
- Authors: Nkeh-Chungag, Benedicta Ngwenchi
- Date: 2022-00
- Subjects: Cardiovascular system--Diseases--Treatment
- Language: English
- Type: Inaugural Lecture , text
- Identifier: http://hdl.handle.net/11260/8030 , vital:59356
- Description: Professor Benedicta Ngwenchi Nkeh-Chungag’s BIO Professor Benedicta Ngwenchi Nkeh-Chungag is a Full Professor of Physiology and Dean of the Faculty of Natural Sciences, Walter Sisulu University. Professor Nkeh-Chungag is an NRF rated researcher, a scholar of the Organization for Women in Science for the Developing World (OWSD), a Fellow of the International Hypertension Society, Deputy President and co-founder of the newly established Childhood Hypertension Consortium of South Africa, Deputy Chairperson of the South African National Committee for International Union for Physiological Sciences (ICSU-IUPS), Chairperson of the Cardiometabolic Research Niche Area – WSU and Chairperson of the Animal Research Ethic Committee. She oversees the Carrier Orientation and International Mentoring Program run by Harness Ideas Association (HIDAS).Professor Nkeh-Chungag has published extensively in the of cardiovascular research covering epidemiology and African medicinal plants. She has served as an Associate Editor for the journal Frontiers in Public Health and is on the editorial board of two journals, Bioinformatics and Clinical Interventions in Aging. She is a member of several knowledge bodies including the International Hypertension Society.As an accomplished and passionate scholar, Professor Nkeh-Chungag enjoys both national and international recognition in her field of research. Her focus on the risk for cardiovascular diseases in children of African ancestry has attracted interest and funding from both national and international organizations. Her research findings have been showcased at many scientific fora including as keynote addresses. Professor Nkeh-Chungag is married to Dr Anye Chungag and they are blessed with four boys. , Inaugural Lecture (Prefessorial) -- Faculty of Natural Sciences, 2022
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- Date Issued: 2022-00
Mxinwa MSc Cover & Abstract.pdf
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7873 , vital:55151
- Full Text:
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7873 , vital:55151
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Researcher Profile and List of Publications - Oyedeji.pdf
- Authors: Oyedeji, Adebola Omowunmi
- Identifier: http://hdl.handle.net/11260/4791 , vital:44254
- Description: Expertise: Organic chemistry-Natural Product Chemist
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- Authors: Oyedeji, Adebola Omowunmi
- Identifier: http://hdl.handle.net/11260/4791 , vital:44254
- Description: Expertise: Organic chemistry-Natural Product Chemist
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Professor
- Authors: Oyedeji, Adebola Omowunmi
- Type: Researcher Profile
- Identifier: http://hdl.handle.net/11260/2721 , vital:42330
- Full Text:
- Authors: Oyedeji, Adebola Omowunmi
- Type: Researcher Profile
- Identifier: http://hdl.handle.net/11260/2721 , vital:42330
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Ellisras Longitudinal Study 2017: association of hypertension with increasing levels of adiposity in 10- to 14-year-old boys and girls in the Eastern Cape (ELS 31)
- CM Tata
- Authors: CM Tata
- Date: 2019
- Language: English
- Type: Article
- Identifier: http://hdl.handle.net/11260/5128 , vital:44352
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- Authors: CM Tata
- Date: 2019
- Language: English
- Type: Article
- Identifier: http://hdl.handle.net/11260/5128 , vital:44352
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Fractionation and bioassay-guided isolation of antihypertensive components of Senecio serratuloides
- Constance Rufaro Sewani-Rusike
- Authors: Constance Rufaro Sewani-Rusike
- Date: 2019
- Language: English
- Type: Journal
- Identifier: http://hdl.handle.net/11260/5135 , vital:44353
- Full Text:
- Authors: Constance Rufaro Sewani-Rusike
- Date: 2019
- Language: English
- Type: Journal
- Identifier: http://hdl.handle.net/11260/5135 , vital:44353
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Shuali Mathulo M Researcher Profile and List of Publications .pdf
- Authors: Shuali Mathulo, M
- Identifier: http://hdl.handle.net/11260/4823 , vital:44263
- Description:
Expertise:
Biomedical Research—Histology/medicinal plants
- Full Text:
- Authors: Shuali Mathulo, M
- Identifier: http://hdl.handle.net/11260/4823 , vital:44263
- Description:
Expertise:
Biomedical Research—Histology/medicinal plants
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Cardiometabolic risk factors and early indicators of vascular dysfunction: a cross-sectional cohort study in South African adolescents
- Letswalo, Boitumelo Prescilla, Schmid-Zalaudek, Karin, Brix, Bianca, Matjuda, Edna Ngoakoana, Klosz, Fabian, Obernhumer, Natalie, Gaisl, Michael, Engwa, Godwill Azeh, Sewani-Rusike, Constance, Fredriksen, Per Morten, Nkeh-Chungag, Benedicta, Goswami, Nandu
- Authors: Letswalo, Boitumelo Prescilla , Schmid-Zalaudek, Karin , Brix, Bianca , Matjuda, Edna Ngoakoana , Klosz, Fabian , Obernhumer, Natalie , Gaisl, Michael , Engwa, Godwill Azeh , Sewani-Rusike, Constance , Fredriksen, Per Morten , Nkeh-Chungag, Benedicta , Goswami, Nandu
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3864 , vital:43959
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- Authors: Letswalo, Boitumelo Prescilla , Schmid-Zalaudek, Karin , Brix, Bianca , Matjuda, Edna Ngoakoana , Klosz, Fabian , Obernhumer, Natalie , Gaisl, Michael , Engwa, Godwill Azeh , Sewani-Rusike, Constance , Fredriksen, Per Morten , Nkeh-Chungag, Benedicta , Goswami, Nandu
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3864 , vital:43959
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Prevalence of metabolic syndrome in adolescents living in Mthatha, south africa
- Sekokotla, Annah, Goswami, Nandu, Sewani-Rusike, Constance Rufaro, Iputo, Jehu Erapu, Nkeh-Chungag, Benedicta Ngwenchi
- Authors: Sekokotla, Annah , Goswami, Nandu , Sewani-Rusike, Constance Rufaro , Iputo, Jehu Erapu , Nkeh-Chungag, Benedicta Ngwenchi
- Date: 2017
- Subjects: South Africa Metabolic syndrome Journal article
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/5983 , vital:45061 , xlink:href="https://doi:10.2147/TCRM.S124291"
- Description: Objective Metabolic syndrome (MetS), defined as the clustering of three of five risk factors (hypertension, obesity, triglyceridemia, dyslipidemia and hyperglycemia), is being increasingly mentioned among children and adolescents despite there being no consensus on how it should be defined in this set of population. Furthermore, very few studies have focused on MetS in children and adolescents in sub-Saharan populations. This study, therefore, aimed at determining the prevalence of the MetS and contributing risk in adolescents living in Mthatha, South Africa. Research design and methods Four hundred and ten adolescents (age range: 13–18 years, both sexes) were recruited into this cross-sectional study. In addition to a lifestyle questionnaire being administered, anthropometric measurements (weight, height and waist circumferences) were carried out for each participant. Fasting venous blood was collected for lipid profile and blood glucose assessments. Blood pressure was also measured. MetS was assessed using appropriate diagnostic criteria for children and adolescents. Results Complete data sets were collected from 371 participants. Females showed an elevation in the risk factors for MetS. Of the 371 participants, 40.2% were overweight/obese (47.5% females; 22.5% males). MetS was diagnosed in 3.1% female participants compared with 6.0% in male participants. Conclusions More risk factors for the MetS are seen among the overweight/obese as compared to lean adolescents. Given the fact that childhood overweight/obesity often continues into adulthood, it is important to address the causes of increased risk for MetS earlier in life to prevent the development of disease in adult life.
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- Date Issued: 2017
- Authors: Sekokotla, Annah , Goswami, Nandu , Sewani-Rusike, Constance Rufaro , Iputo, Jehu Erapu , Nkeh-Chungag, Benedicta Ngwenchi
- Date: 2017
- Subjects: South Africa Metabolic syndrome Journal article
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/5983 , vital:45061 , xlink:href="https://doi:10.2147/TCRM.S124291"
- Description: Objective Metabolic syndrome (MetS), defined as the clustering of three of five risk factors (hypertension, obesity, triglyceridemia, dyslipidemia and hyperglycemia), is being increasingly mentioned among children and adolescents despite there being no consensus on how it should be defined in this set of population. Furthermore, very few studies have focused on MetS in children and adolescents in sub-Saharan populations. This study, therefore, aimed at determining the prevalence of the MetS and contributing risk in adolescents living in Mthatha, South Africa. Research design and methods Four hundred and ten adolescents (age range: 13–18 years, both sexes) were recruited into this cross-sectional study. In addition to a lifestyle questionnaire being administered, anthropometric measurements (weight, height and waist circumferences) were carried out for each participant. Fasting venous blood was collected for lipid profile and blood glucose assessments. Blood pressure was also measured. MetS was assessed using appropriate diagnostic criteria for children and adolescents. Results Complete data sets were collected from 371 participants. Females showed an elevation in the risk factors for MetS. Of the 371 participants, 40.2% were overweight/obese (47.5% females; 22.5% males). MetS was diagnosed in 3.1% female participants compared with 6.0% in male participants. Conclusions More risk factors for the MetS are seen among the overweight/obese as compared to lean adolescents. Given the fact that childhood overweight/obesity often continues into adulthood, it is important to address the causes of increased risk for MetS earlier in life to prevent the development of disease in adult life.
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- Date Issued: 2017
Phytochemical composition, and analgesic and antiinflammatory properties of essential oil of Chamaemelum nobile (Asteraceae L All) in rodents
- Adebola O Oyedeji, Benedicta N Nkeh-Chungag
- Authors: Adebola O Oyedeji , Benedicta N Nkeh-Chungag
- Date: 2017
- Identifier: http://hdl.handle.net/11260/1496 , vital:37761
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- Authors: Adebola O Oyedeji , Benedicta N Nkeh-Chungag
- Date: 2017
- Identifier: http://hdl.handle.net/11260/1496 , vital:37761
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NDEBIA_June_2021_9_2_1-5.pdf
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7633 , vital:54747
- Full Text:
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7633 , vital:54747
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s12872-021-02130-2.pdf
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7674 , vital:54760
- Full Text:
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7674 , vital:54760
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Hepatoprotective Effects of Fadogia ancylantha (Makoni Tea) on Ethanol-Induced Liver Damage in Wistar Rats
- Sibahle Y Tiya, Constance R Sewani-Rusike
- Authors: Sibahle Y Tiya , Constance R Sewani-Rusike
- Date: 2019
- Language: English
- Type: Journal
- Identifier: http://hdl.handle.net/11260/5144 , vital:44354
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- Authors: Sibahle Y Tiya , Constance R Sewani-Rusike
- Date: 2019
- Language: English
- Type: Journal
- Identifier: http://hdl.handle.net/11260/5144 , vital:44354
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e042955.full.pdf
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7709 , vital:54742
- Full Text:
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7709 , vital:54742
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Antihypertensive effects of the hydroethanol extract of Senecio serratuloides DC in rats
- Tata, Charlotte Mungho, Sewani-Rusike, Constance Rufaro, Oyedeji, Opeoluwa Oyehan, Gwebu, Ephraim Tobela, Mahlakata, Fikile, Nkeh-Chungag, Benedicta Ngwenchi
- Authors: Tata, Charlotte Mungho , Sewani-Rusike, Constance Rufaro , Oyedeji, Opeoluwa Oyehan , Gwebu, Ephraim Tobela , Mahlakata, Fikile , Nkeh-Chungag, Benedicta Ngwenchi
- Date: 2019
- Subjects: South Africa Hypertension Computer File
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/5847 , vital:44656 , https://doi.org/10.1186/s12906-019-2463-2
- Description: Senecio serratuloides DC is used in folk medicine for treating hypertension, skin disorders, internal and external sores, rashes, burns and wounds. This study aimed at investigating the antihypertensive effects of the hydroethanol extract of S. serratuloides (HESS) in N-Nitro-L-arginine methyl ester (L-NAME) induced hypertension in rats. Methods: Acute toxicity of HESS was first determined to provide guidance on doses to be used in this study. Lorke’s method was used to determine safety of the extract in mice. Female Wistar rats were treated orally once daily with L-NAME (40 mg/kg) for 4 weeks and then concomitantly with L-NAME (20 mg/kg) and plant extract (150 and 300 mg/kg), captopril (20 mg/kg) or saline as per assigned group for 2 weeks followed by a 2-week period of assigned treatments only. Blood pressure was monitored weekly. Lipid profile, nitric oxide, renin and angiotensin II concentrations were determined in serum while mineralocorticoid receptor concentration was quantified in the kidney homogenate. Nitric oxide (NO) concentration was determined in serum and cardiac histology performed. Results HESS was found to be non-toxic, having a LD50 greater than 5000 mg/kg. Blood pressure increased progressively in all animals from the second week of L-NAME treatment. HESS treatment significantly and dose-dependently lowered systolic blood pressure (p less 0.001), diastolic blood pressure (p less 0.01), low density lipoprotein cholesterol (p less 0.01) and triglycerides (p less 0.01). It significantly prevented L-NAME induced decrease in serum angiotensin II (p less 0.01), high density lipoprotein cholesterol (p less 0.001) and serum nitric oxide concentrations (p less 0.001). HESS also significantly (p less 0.01) prevented collagen deposition in cardiac tissue. Conclusion The hydro-ethanol extract of Senecio serratuloides showed antihypertensive, antihyperlipidemic and cardioprotective effects in rats thus confirming its usefulness in traditional antihypertensive therapy and potential for antihypertensive drug development.
- Full Text:
- Date Issued: 2019
- Authors: Tata, Charlotte Mungho , Sewani-Rusike, Constance Rufaro , Oyedeji, Opeoluwa Oyehan , Gwebu, Ephraim Tobela , Mahlakata, Fikile , Nkeh-Chungag, Benedicta Ngwenchi
- Date: 2019
- Subjects: South Africa Hypertension Computer File
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/5847 , vital:44656 , https://doi.org/10.1186/s12906-019-2463-2
- Description: Senecio serratuloides DC is used in folk medicine for treating hypertension, skin disorders, internal and external sores, rashes, burns and wounds. This study aimed at investigating the antihypertensive effects of the hydroethanol extract of S. serratuloides (HESS) in N-Nitro-L-arginine methyl ester (L-NAME) induced hypertension in rats. Methods: Acute toxicity of HESS was first determined to provide guidance on doses to be used in this study. Lorke’s method was used to determine safety of the extract in mice. Female Wistar rats were treated orally once daily with L-NAME (40 mg/kg) for 4 weeks and then concomitantly with L-NAME (20 mg/kg) and plant extract (150 and 300 mg/kg), captopril (20 mg/kg) or saline as per assigned group for 2 weeks followed by a 2-week period of assigned treatments only. Blood pressure was monitored weekly. Lipid profile, nitric oxide, renin and angiotensin II concentrations were determined in serum while mineralocorticoid receptor concentration was quantified in the kidney homogenate. Nitric oxide (NO) concentration was determined in serum and cardiac histology performed. Results HESS was found to be non-toxic, having a LD50 greater than 5000 mg/kg. Blood pressure increased progressively in all animals from the second week of L-NAME treatment. HESS treatment significantly and dose-dependently lowered systolic blood pressure (p less 0.001), diastolic blood pressure (p less 0.01), low density lipoprotein cholesterol (p less 0.01) and triglycerides (p less 0.01). It significantly prevented L-NAME induced decrease in serum angiotensin II (p less 0.01), high density lipoprotein cholesterol (p less 0.001) and serum nitric oxide concentrations (p less 0.001). HESS also significantly (p less 0.01) prevented collagen deposition in cardiac tissue. Conclusion The hydro-ethanol extract of Senecio serratuloides showed antihypertensive, antihyperlipidemic and cardioprotective effects in rats thus confirming its usefulness in traditional antihypertensive therapy and potential for antihypertensive drug development.
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- Date Issued: 2019
Predictors of recovery in moderate to severe traumatic brain injury
- Kadhaya David Muballe, Constance R. Sewani-Rusike, Benjamin Longo-Mbenza, Jehu Iputo
- Authors: Kadhaya David Muballe , Constance R. Sewani-Rusike , Benjamin Longo-Mbenza , Jehu Iputo
- Date: 2019
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/3694 , vital:43927
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- Authors: Kadhaya David Muballe , Constance R. Sewani-Rusike , Benjamin Longo-Mbenza , Jehu Iputo
- Date: 2019
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/3694 , vital:43927
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Insulin Resistance is Associated with Gut Permeability Without the Direct Influence of Obesity in Young Adults
- Mkumbuzi, Lusikelelwe, Engwa, Godwill Azeh, Sewani-Rusike, Constance R, Mfengu, Mvuyisi M O
- Authors: Mkumbuzi, Lusikelelwe , Engwa, Godwill Azeh , Sewani-Rusike, Constance R , Mfengu, Mvuyisi M O
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4582 , vital:44136
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- Authors: Mkumbuzi, Lusikelelwe , Engwa, Godwill Azeh , Sewani-Rusike, Constance R , Mfengu, Mvuyisi M O
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4582 , vital:44136
- Full Text:
Acute toxicity study and prevention of Nω-nitro-L-arginine methyl ester-induced hypertension by Osteopermum imbricatum
- Tata, Charlotte, M, Gwebu, Ephraim, T, Olukayode O Aremu, Nkeh-Chungag, Benedicta, N, Oyedeji, Adebola, O, Oyedeji, Opeopluwa, O, Sewani-Rusike, Constance, R
- Authors: Tata, Charlotte, M , Gwebu, Ephraim, T , Olukayode O Aremu , Nkeh-Chungag, Benedicta, N , Oyedeji, Adebola, O , Oyedeji, Opeopluwa, O , Sewani-Rusike, Constance, R
- Date: June-2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4915 , vital:44303 , https://www.ajol.info/index.php/tjpr/article/view/174343
- Description: Purpose:To determine the phytochemical content, toxicity and hypertension prevention effects of Osteospermum imbricatum leaf and root extracts.Methods:Phytochemical screening of leaf and root extracts of O. imbricatum was performed by colorimetric procedure. Acute toxicity of leaf and root extracts was conductedin two phases; phase I consisted of three groups of mice (n = 3) for each dose level of 10, 100 and 1000 mg/kg while phase II had three mice that received 1600, 2900 or 5000 mg/kg. Wistar rats were grouped into 7 groups that were co-treated with L-NAME and normal saline or L-NAME and hydroethanolic leaf extract (150 and 300 mg/kg) or L-NAME and hydroethanolic root extract (150 and 300 mg/kg) or L-NAME and amlodipine (5 mg/kg) or normal saline only for 4 weeks. Treatment was carried out via the oral route while blood pressure was measured weeklyfor 4 weeks by non-invasive tail cuff method.Results:The phytochemical profile of the leaf and root extracts revealed the presence of phenols, terpenoids, flavonoids, glycosides, tannins, steroids and saponins. Both the leaf and root extracts were toxic at 5000 mg/kg with an LD50of 3807.89 mg/kg. In the fourth week of the study, only the leaf extract significantly (p less 0.01) prevented the progression of L-NAME induced hypertension; systolic and diastolic blood pressure of the group treated with L-NAME and leaf extract (300 mg/kg) were 183 ± 1 and 140 ± 1 mmHg, respectively, compared to the group that was treated with L-NAME and normal saline which produced systolic and diastolic BP values of 213 ± 3 and 172 ± 4 mmHg, respectively. The extracts, especially OIR300, exhibited diuretic effects in the second and third week of study by promoting excretion of 16 and 19 ml urine, respectively, compared to 11 and 14 ml for LN group.Conclusion:The results suggest that O. imbricatum is moderately toxic at a high dose and contains a wide range of phytochemicals which offer partial protection against the development of nitric oxide deficiency hypertension.
- Full Text:
- Date Issued: June-2018
- Authors: Tata, Charlotte, M , Gwebu, Ephraim, T , Olukayode O Aremu , Nkeh-Chungag, Benedicta, N , Oyedeji, Adebola, O , Oyedeji, Opeopluwa, O , Sewani-Rusike, Constance, R
- Date: June-2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4915 , vital:44303 , https://www.ajol.info/index.php/tjpr/article/view/174343
- Description: Purpose:To determine the phytochemical content, toxicity and hypertension prevention effects of Osteospermum imbricatum leaf and root extracts.Methods:Phytochemical screening of leaf and root extracts of O. imbricatum was performed by colorimetric procedure. Acute toxicity of leaf and root extracts was conductedin two phases; phase I consisted of three groups of mice (n = 3) for each dose level of 10, 100 and 1000 mg/kg while phase II had three mice that received 1600, 2900 or 5000 mg/kg. Wistar rats were grouped into 7 groups that were co-treated with L-NAME and normal saline or L-NAME and hydroethanolic leaf extract (150 and 300 mg/kg) or L-NAME and hydroethanolic root extract (150 and 300 mg/kg) or L-NAME and amlodipine (5 mg/kg) or normal saline only for 4 weeks. Treatment was carried out via the oral route while blood pressure was measured weeklyfor 4 weeks by non-invasive tail cuff method.Results:The phytochemical profile of the leaf and root extracts revealed the presence of phenols, terpenoids, flavonoids, glycosides, tannins, steroids and saponins. Both the leaf and root extracts were toxic at 5000 mg/kg with an LD50of 3807.89 mg/kg. In the fourth week of the study, only the leaf extract significantly (p less 0.01) prevented the progression of L-NAME induced hypertension; systolic and diastolic blood pressure of the group treated with L-NAME and leaf extract (300 mg/kg) were 183 ± 1 and 140 ± 1 mmHg, respectively, compared to the group that was treated with L-NAME and normal saline which produced systolic and diastolic BP values of 213 ± 3 and 172 ± 4 mmHg, respectively. The extracts, especially OIR300, exhibited diuretic effects in the second and third week of study by promoting excretion of 16 and 19 ml urine, respectively, compared to 11 and 14 ml for LN group.Conclusion:The results suggest that O. imbricatum is moderately toxic at a high dose and contains a wide range of phytochemicals which offer partial protection against the development of nitric oxide deficiency hypertension.
- Full Text:
- Date Issued: June-2018
Relationship between Endothelial Function, Antiretroviral Treatment and Cardiovascular Risk Factors in HIV Patients of African Descent in South Africa: A Cross-Sectional Study
- Benedicta N. Nkeh-Chungag, Goswami, Nandu, Engwa, Godwill Azeh, Sewani-Rusike, Constance R, Mbombela, Vuyolwethu, Ingrid WebsterPatrick De Boever, Kessler, Harald H, Stelzl, Evelyn
- Authors: Benedicta N. Nkeh-Chungag , Goswami, Nandu , Engwa, Godwill Azeh , Sewani-Rusike, Constance R , Mbombela, Vuyolwethu , Ingrid WebsterPatrick De Boever , Kessler, Harald H , Stelzl, Evelyn
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3998 , vital:43982
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- Authors: Benedicta N. Nkeh-Chungag , Goswami, Nandu , Engwa, Godwill Azeh , Sewani-Rusike, Constance R , Mbombela, Vuyolwethu , Ingrid WebsterPatrick De Boever , Kessler, Harald H , Stelzl, Evelyn
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3998 , vital:43982
- Full Text:
s12906-021-03459-z.pdf
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7690 , vital:54757
- Full Text:
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7690 , vital:54757
- Full Text: