In vitro-in vivo evaluation of a sustained release phenylpropanolamine oral dosage form
- Dowse, Roslind, Haigh, John M, Kanfer, Isadore
- Authors: Dowse, Roslind , Haigh, John M , Kanfer, Isadore
- Date: 1982
- Language: English
- Type: Article
- Identifier: vital:6360 , http://hdl.handle.net/10962/d1006052
- Description: There is increasing interest in measuring pharmacokinetic parameters of phenylpropanolamine (PPA), a sympathomimetic amine used in over-the-counter nasal decongestants and anorectic formulations. A high pressure liquid chromatographic (HPLC) procedure was developed to enable direct ultraviolet detection of PPA, after extraction from serum and urine, without prior derivatization of the drug. This method was used to assay samples obtained from a bioavailability study of BUBtained-releasePPA tablets. The mean serum and urine profiles obtained are presented. The sustained-release tablets were subjected to dissolution testing utilizing the United States Pharmacopoeia (USP XIX) rotating basket method. An internal standard was incorporated into the dissolution fluid to enable direct analysis of the samples by HPLC. A comparison of three different dissolution fluid regimens was carried out to determine if release of the drug was affected by the change in pH of the medium and to select the most convenient method for the final dissolution studies. Some preliminary observations relating to correlations between rate of drug release from the sustained-release dosage form and percent drug absorbed are presented.
- Full Text:
- Date Issued: 1982
- Authors: Dowse, Roslind , Haigh, John M , Kanfer, Isadore
- Date: 1982
- Language: English
- Type: Article
- Identifier: vital:6360 , http://hdl.handle.net/10962/d1006052
- Description: There is increasing interest in measuring pharmacokinetic parameters of phenylpropanolamine (PPA), a sympathomimetic amine used in over-the-counter nasal decongestants and anorectic formulations. A high pressure liquid chromatographic (HPLC) procedure was developed to enable direct ultraviolet detection of PPA, after extraction from serum and urine, without prior derivatization of the drug. This method was used to assay samples obtained from a bioavailability study of BUBtained-releasePPA tablets. The mean serum and urine profiles obtained are presented. The sustained-release tablets were subjected to dissolution testing utilizing the United States Pharmacopoeia (USP XIX) rotating basket method. An internal standard was incorporated into the dissolution fluid to enable direct analysis of the samples by HPLC. A comparison of three different dissolution fluid regimens was carried out to determine if release of the drug was affected by the change in pH of the medium and to select the most convenient method for the final dissolution studies. Some preliminary observations relating to correlations between rate of drug release from the sustained-release dosage form and percent drug absorbed are presented.
- Full Text:
- Date Issued: 1982
Brotherhood of Breath: Yes please
- Unknown
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group) , Beckett, Harry
- Language: French
- Type: Article
- Identifier: vital:13685 , http://hdl.handle.net/10962/d1012691
- Description: Photocopied article from Jazz Magazine about the recording "Yes please" (Musica Distribution) by Chris McGregor's Brotherhood of Breath.
- Full Text:
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group) , Beckett, Harry
- Language: French
- Type: Article
- Identifier: vital:13685 , http://hdl.handle.net/10962/d1012691
- Description: Photocopied article from Jazz Magazine about the recording "Yes please" (Musica Distribution) by Chris McGregor's Brotherhood of Breath.
- Full Text:
Chris McGregor's Brotherhood of Breath
- Authors: Meignan, Armand
- Subjects: McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group)
- Language: French
- Type: Article
- Identifier: vital:13611 , http://hdl.handle.net/10962/d1012479 , McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group)
- Description: Photocopied article from the magazine Jazz Hot about a recording (Yes please) by Chris McGregor's Brotherhood of Breath at a concert in Angoulême.
- Full Text:
- Authors: Meignan, Armand
- Subjects: McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group)
- Language: French
- Type: Article
- Identifier: vital:13611 , http://hdl.handle.net/10962/d1012479 , McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group)
- Description: Photocopied article from the magazine Jazz Hot about a recording (Yes please) by Chris McGregor's Brotherhood of Breath at a concert in Angoulême.
- Full Text:
Chris McGregor's Brotherhood of Breath: "Yes please"
- Unknown
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group) , Jazz
- Language: French
- Type: Article
- Identifier: vital:13693 , http://hdl.handle.net/10962/d1012701
- Description: Photocopied article about the recording "Yes please" (Musica distribution) by Chris McGregor's Brotherhood of Breath.
- Full Text:
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group) , Jazz
- Language: French
- Type: Article
- Identifier: vital:13693 , http://hdl.handle.net/10962/d1012701
- Description: Photocopied article about the recording "Yes please" (Musica distribution) by Chris McGregor's Brotherhood of Breath.
- Full Text:
Chris McGregor: "Yes please"
- Unknown
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group) , Jazz
- Language: French
- Type: Article
- Identifier: vital:13699 , http://hdl.handle.net/10962/d1012708
- Description: Photocopied article from the French newspaper Le Monde about the recording "Yes please" (Musica Distribution) by Chris McGregor's Brotherhood of Breath.
- Full Text:
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group) , Jazz
- Language: French
- Type: Article
- Identifier: vital:13699 , http://hdl.handle.net/10962/d1012708
- Description: Photocopied article from the French newspaper Le Monde about the recording "Yes please" (Musica Distribution) by Chris McGregor's Brotherhood of Breath.
- Full Text:
Music from elsewhere
- Authors: Nighthawk
- Language: French
- Type: Article
- Identifier: vital:13623 , http://hdl.handle.net/10962/d1012498
- Description: Photocopied article in French about various concerts with music from all over the world, including a piano solo performance by Chris McGregor. There is a photo of Chris McGregor with this article.
- Full Text:
- Authors: Nighthawk
- Language: French
- Type: Article
- Identifier: vital:13623 , http://hdl.handle.net/10962/d1012498
- Description: Photocopied article in French about various concerts with music from all over the world, including a piano solo performance by Chris McGregor. There is a photo of Chris McGregor with this article.
- Full Text:
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