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STIP1/HOP regulates the actin cytoskeleton through interactions with actin and changes in actin-binding proteins cofilin and profilin:

  • Authors: Beckley, Samantha Joy , Hunter, Morgan C , Kituyi, Sarah N , Wingate, Ianthe , Chakraborty, Abantika , Schwarz, Kelly , Makhubu, Matodzi P , Rousseau, Robert P , Ruck, Duncan K , de la Mare, Jo-Anne , Blatch, Gregory L , Edkins, Adrienne L
  • Date: 2020
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/165373 , vital:41238 , https://doi.org/10.3390/ijms21093152
  • Description: Cell migration plays a vital role in both health and disease. It is driven by reorganization of the actin cytoskeleton, which is regulated by actin-binding proteins cofilin and profilin. Stress-inducible phosphoprotein 1 (STIP1) is a well-described co-chaperone of the Hsp90 chaperone system, and our findings identify a potential regulatory role of STIP1 in actin dynamics. We show that STIP1 can be isolated in complex with actin and Hsp90 from HEK293T cells and directly interacts with actin in vitro via the C-terminal TPR2AB-DP2 domain of STIP1, potentially due to a region spanning two putative actin-binding motifs. We found that STIP1 could stimulate the in vitro ATPase activity of actin, suggesting a potential role in the modulation of F-actin formation. Interestingly, while STIP1 depletion in HEK293T cells had no major effect on total actin levels, it led to increased nuclear accumulation of actin, disorganization of F-actin structures, and an increase and decrease in cofilin and profilin levels, respectively. This study suggests that STIP1 regulates the cytoskeleton by interacting with actin, or via regulating the ratio of proteins known to affect actin dynamics.
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  • Date Issued: 2020

String diagrams for modelling functional programming

  • Authors: Motara, Yusuf, M
  • Date: 2020
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/429022 , vital:72554 , https://ieeexplore.ieee.org/abstract/document/9334072
  • Description: It is currently impossible to model functional programs in the same way that UML is used to model object-oriented programs: no analogous graphical notation exists. Unlike object-oriented programs, however, functional programming is built on a solid mathematical basis and it may be possible to adapt graphical notation from the mathematical domain for such modelling. This work examines string diagrams as a way to model certain functional abstractions. A proposed notation is demonstrated in the contexts of equational reasoning and descriptive modelling, and is found to be suitable for both.
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  • Date Issued: 2020

Structural Characterization of Carbonic Anhydrase VIII and Effects of Missense Single Nucleotide Variations to Protein Structure and Function:

  • Authors: Sanyanga, Taremekedzwa Allan , Tastan Bishop, Özlem
  • Date: 2020
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/149670 , vital:38873 , https://doi.org/10.3390/ijms21082764
  • Description: Human carbonic anhydrase 8 (CA-VIII) is an acatalytic isoform of the α -CA family. Though the protein cannot hydrate CO2, CA-VIII is essential for calcium (Ca2+) homeostasis within the body, and achieves this by allosterically inhibiting the binding of inositol 1,4,5-triphosphate (IP3) to the IP3 receptor type 1 (ITPR1) protein. However, the mechanism of interaction of CA-VIII to ITPR1 is not well understood. In addition, functional defects to CA-VIII due to non-synonymous single nucleotide polymorphisms (nsSNVs) result in Ca2+ dysregulation and the development of the phenotypes such as cerebellar ataxia, mental retardation and disequilibrium syndrome 3 (CAMRQ3). The pathogenesis of CAMRQ3 is also not well understood. The structure and function of CA-VIII was characterised, and pathogenesis of CAMRQ3 investigated. Structural and functional characterisation of CA-VIII was conducted through SiteMap and CPORT to identify potential binding site residues.
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  • Date Issued: 2020

Study of Star-Forming Regions in the Peculiar Galaxies NGC 660, NGC 1512, NGC 4395, and NGC 4618:

  • Authors: Smirnova, K I , Wiebe, D S , Moiseev, A V , Jozsa, G I G
  • Date: 2020
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/160456 , vital:40447 , https://0-doi.org.wam.seals.ac.za/10.1134/S199034132003013X
  • Description: The star-forming regions (SFRs) in the peculiar galaxies NGC 660, NGC 1512, NGC 4395 and NGC 4618 are studied. The relationships between such characteristics of star forming regions as UV, near- and far-IR fluxes, as well as in the Hα and HI lines, surface brightness in these ranges, and the scatter of the radial velocities of ionized and neutral hydrogen are considered. It is shown that in all the galaxies considered, the IR fluxes from SFRs are less than in the “normal” galaxies, but for different reasons: in the galaxies with signs of recent interaction NGC 660 and NGC 1512, this is due to the low surface brightness of SFRs; in the lopsided galaxies NGC 4395 and NGC 4618, the low brightness of SFRs in the infrared range is due to their compact size. These differences indicate that the star formation process depends not only on the morphological type of a galaxy, but also on many other factors.
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  • Date Issued: 2020

Substituent effect on the photophysical and nonlinear optical characteristics of Si phthalocyanine–Detonated nanodiamond conjugated systems in solution

  • Authors: Matshitse, Refilwe , Nyokong, Tebello
  • Date: 2020
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/186293 , vital:44482 , xlink:href="https://doi.org/10.1016/j.ica.2020.119447"
  • Description: This work reports on the photophysical, nonlinear absorption and optical limiting properties of detonation nanodiamonds (DNDs)-silicon phthalocyanine nanoconjugate systems. Si(IV) hydroxide phthalocyanines employed are: 2,9(10),16(17),23(24)-tetrakis-(4-pyridyloxy) phthalocyaninato (Si(OH)2TPPc), 2,9(10),16(17),23(24)-tetrakis-(4-tert-butyl) phthalocyanato (Si(OH)2TBPc) and phthalocyanato(Si(OH)2Pc). Pcs were covalently linked to nanondiamonds and investigated using 532 nm laser excitation at 7 ns pulses for their optical limiting properties. Si(OH)2TBPc and Si(OH)2Pc gave larger triplet quantum yields when linked to DNDs, while the value decreased for Si(OH)2TPPc in the presence of DNDs due to aggregation. However all Pcs showed enhanced nonlinear optical properties in the presence of DNDs. DNDs-Si(OH)2TPPc and DNDs-Si (OH)2TBPc gave the highest imaginary third-order susceptibility (Im[X(3)]) and hyperpolarizability (γ) at 5.19 × 10−8 and 3.85 × 10−8 esu and 2.66 × 10−27 and 1.97 × 10−27 esu, respectively. DNDs-Si(OH)2TBPc nanoconjugates showed lowest limiting threshold (Ilim) value of 0.01 J.cm−2 relative to 0.09 for DNDs-Si (OH)2TPPc.
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  • Date Issued: 2020

Susceptibility of Staphylococcus aureus to porphyrin-silver nanoparticle mediated photodynamic antimicrobial chemotherapy

  • Authors: Shabangu, Samuel M , Babu, Balaji , Soy, Rodah C , Ovim, James , Amuhaya, Edith , Nyokong, Tebello
  • Date: 2020
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/186262 , vital:44479 , xlink:href="https://doi.org/10.1016/j.jlumin.2020.117158"
  • Description: Photodynamic antimicrobial chemotherapy (PACT) is employed against multi drug resistant Staphylococcus aureus using porphyrins combined with silver nanoparticles to bring about a combined photodynamic effect. We employ Zn-meso-5,10,15,20-tetra(4-pyridyl) (1), Zn-meso-5,10,15,20-tetrathienyl (2), and Zn-meso-5-(4- hydroxyphenyl)- 10,15,20-tris(2-thienyl)(3) porphyrins and their self-assembled conjugates with silver nanoparticles for PACT against Staphylococcus aureus. Complex 3 with nanoparticles was found to perform better resulting in 0% bacterial viability at 60 min.
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  • Date Issued: 2020

Sustainable conflict resolution through community based Water, Sanitation and Hygiene (WASH) Planning in fragile and conflict situations: the case of Somalia

  • Authors: Mafuta, Wonder , Zuwarimwe, Jethro , Kamuzhanje, Joseph , Mwale, Marizvikuru , Chipaike, Ronald
  • Date: 2020
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/150241 , vital:38952 , https://0-doi.org.wam.seals.ac.za/10.1177/0021909620928104
  • Description: The study examines the nature of disputes, which are prevalent in water, sanitation and hygiene (WASH) programming and suggests possible conflict management and resolution mechanisms. An online web-based survey, hosted on the popular Survey Monkey platform, was conducted through the Somalia WASH Cluster to 40 ‘active’ member organisations. A response rate of 73% was achieved. Thematic analysis was conducted using NVivo 12. The type of conflicts identified are as follows: visible versus non-visible benefits, emergency versus development focus, the young and the old, insiders versus outsiders, local versus donor priorities and men versus women. The article goes on to suggest possible conflict resolution mechanisms, which include: planning together with communities, continuum programming, setting up early warning systems, harmonisation of institutions managing WASH resources and the development of localised Memorandums of Understanding. It is recommended that the complexities of conflict and fragility require different approaches. The approaches would apply to both relief and developmental WASH programming.
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  • Date Issued: 2020

Synergistic effects of temperature and plant quality, on development time, size and lipid in Eccritotarsus eichhorniae

  • Authors: Ismail, Mohannad , Brooks, Margot , Van Baaren, Joan , Albittar, Loulou
  • Date: 2020
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/426078 , vital:72312 , xlink:href="https://doi.org/10.1111/jen.12841"
  • Description: Body size is an important biotic factor in evolutionary ecology, since it affects all aspects of insect physiology, life history and, consequently, fitness in ectothermic insects and how species adapt with their environment. It has been linked to tem-perature, with lower temperatures resulting in larger size. In this study, we tested the combined impact of temperature and plant quality on the body size, and de-velopment time from egg to adult of Eccritotarsus eichhorniae (Hemiptera: Miridae), an herbivorous insect used as a biological control agent against the invasive aquatic weed, water hyacinth Eichhornia crassipes (Pontederiaceae). We quantified insect size in individuals exposed to three temperatures (20, 25 and 30°C) combined with three qualities of host plant (high, medium and low) by calculating development time and measuring four traits: tibia length, forewing length, dry body mass and lipid con-tent, and we also determined the wing loading index. The development time, dry body mass and lipid content decreased linearly with increasing temperature and de-creasing plant quality. The decrease in size was the greatest when high temperature interacted with low plant quality. Smaller individuals had proportionately less lipid content. Wing loading decreased significantly with lower quality of host plant, result-ing in individuals likely to have theoretically higher flight ability. The results support the temperature-size rule (TSR) and that plant quality could influence the relationship between development time and the TSR. Results also provide novel evidence for a possible food quality-size rule for both sexes.
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  • Date Issued: 2020

Synthesis and biological evaluation of bis-N2, N2′-(4-hydroxycoumarin-3-yl) ethylidene]-2, 3-dihydroxysuccinodihydrazides

  • Authors: Manyeruke, Meloddy H , Tshiwawa, Thendamudzimu , Hoppe, Heinrich , Isaacs, Michelle , Seldon, Ronnett , Warner, Digby F , Krause, Rui W M , Kaye, Perry T
  • Date: 2020
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/193430 , vital:45331 , xlink:href="https://doi.org/10.1016/j.bmcl.2019.126911"
  • Description: A series of N2,N2′-bis[4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccino-hydrazides, containing 4-hydroxycoumarin, hydrazine and tartaric acid moieties, have been prepared and examined for possible biological activity. Several of these compounds exhibit promising HIV-1 integrase inhibition (IC50 = 3.5 μM), and anti-T. brucei (32% viability) and anti-mycobacterial (Visual MIC90 = 15.63 μM) activity.
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  • Date Issued: 2020

Synthesis and pharmacological evaluation of chlorin derivatives for photodynamic therapy of cholangiocarcinoma

  • Authors: Gao, Ying-Hua , Li, Man-Yi , Saijad, Faiza , Wang, Jin-Hai , Meharban, Faiza , Gadoora, Malaz A , Yan, Yi-Jia , Nyokong, Tebello , Chen, Zhi-Long
  • Date: 2020
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/190873 , vital:45036 , xlink:href="https://doi.org/10.1016/j.ejmech.2020.112049"
  • Description: Photodynamic therapy (PDT) has been developed as a promising therapeutic method in cancer treatment. The discovery of effective photosensitizer, which is the key factor of PDT, is highly desired. This paper reports the synthesis of novel chlorin derivatives, 5,10,15,20-tetraphenyl-[2:3]-[(methoxycarbonyl, carboxy)methano] chlorin I and 5,10,15,20-tetraphenyl-[2:3]- {[methoxycarbonyl, (2-hydroxyethyl)amide]methano}chlorin II. Their structures were characterized with UV–vis, 1HNMR, 13CNMR and HRMS spectroscopies. Photophysical and photochemical experiments results showed that compound I and II had an absorption maximum around 650 nm, with molar extinction coefficients of 1 × 104 M−1 cm−1. They had strong fluorescence emission in 650–660 nm upon excitation with 419–422 nm light. ESR showed that singlet oxygen was produced upon irradiation of compounds with 650 nm light in the presence of molecular oxygen. The photo-bleaching test indicated that the structure of compounds was stable. These new compounds exhibit excellent anti-tumor effects and lower toxicity compared to m-THPC in vitro and in vivo. Compound I and II had high tumor selectivity, which could induced tumor cells shrinkage and necrosis under 650 nm laser irradiation. Flow cytometry revealed that the compounds might mediate PDT effect at late apoptotic phase. These results make these compound I and II promising candidates for future study in photo-diagnosis and photodynamic therapy of cholangiocarcinoma.
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  • Date Issued: 2020

Synthesis of novel Schiff base cobalt (II) and iron (iii) complexes as cathode catalysts for microbial fuel cell applications

  • Authors: Sen, Pinar , Akagunduz, Dilan , Aghdam, Araz S , Cebeci, Fevzi C , Nyokong, Tebello , Catal, Tunc
  • Date: 2020
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/190861 , vital:45035 , xlink:href="https://doi.org/10.1007/s10904-019-01286-x"
  • Description: In this study, the synthesis and characterization of a new Schiff base and its cobalt(II) and iron(III) complexes were performed fully characterized by common spectroscopic techniques such as 1H-NMR, 13C-NMR, FT-IR, UV–Vis and MS and elemental analysis. The cathodes prepared with only activated carbon, Co-Schiff base complex, and Fe-Schiff base complex mixed with activated carbon as the carrier were examined in single chamber air cathode microbial fuel cells (MFCs). The spectroscopic results confirm the structure of novel Schiff base and its complexes with cobalt (II) and Fe(III). MFC results showed that Fe-Schiff base complex generated higher voltage generation using glucose as the carbon source. Cyclic voltammetry results showed the conductivity and catalytic features of the cathodes developed in this study. Scanning electron microscopic results showed the distribution the complexes on the cathode surface. In conclusion, a novel Schiff base and its complexes with cobalt (II) and iron (III) can be employed into MFC technology to be used in green electricity production, and might help decreasing the operating costs of wastewater treatment plants.
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  • Date Issued: 2020

Synthesis of novel Schiff base cobalt (II) and iron (iii) complexes as cathode catalysts for microbial fuel cell applications

  • Authors: Sen, Pinar , Akagunduz, Dilan , Aghdam, Araz Sheibani , Cebeci, Fevzi C , Nyokong, Tebello
  • Date: 2020
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/187015 , vital:44556 , xlink:href="https://doi.org/10.1007/s10904-019-01286-x"
  • Description: In this study, the synthesis and characterization of a new Schiff base and its cobalt(II) and iron(III) complexes were performed fully characterized by common spectroscopic techniques such as 1H-NMR, 13C-NMR, FT-IR, UV–Vis and MS and elemental analysis. The cathodes prepared with only activated carbon, Co-Schiff base complex, and Fe-Schiff base complex mixed with activated carbon as the carrier were examined in single chamber air cathode microbial fuel cells (MFCs). The spectroscopic results confirm the structure of novel Schiff base and its complexes with cobalt (II) and Fe(III). MFC results showed that Fe-Schiff base complex generated higher voltage generation using glucose as the carbon source. Cyclic voltammetry results showed the conductivity and catalytic features of the cathodes developed in this study. Scanning electron microscopic results showed the distribution the complexes on the cathode surface. In conclusion, a novel Schiff base and its complexes with cobalt (II) and iron (III) can be employed into MFC technology to be used in green electricity production, and might help decreasing the operating costs of wastewater treatment plants.
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  • Date Issued: 2020

Synthesis of pH sensitive dual capped CdTe QDs: their optical properties and structural morphology

  • Authors: Daramola, Olamide A , Noundou, Xavier S , Nkanga, Christian I , Tseki, Potlaki F , Krause, Rui W M
  • Date: 2020
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/156364 , vital:39983 , https://doi.org/10.1007/s10895-020-02526-x
  • Description: We herein report five different types of thiol dual capped cadmium tellurite quantum dots (CdTe QDs) namely glutathionemercapto-propanoic acid (QD 1), glutathione-thiolglycolic acid (QD 2), L-cysteine-mercapto-propanoic acid (QD 3), L-cysteinethiol-glycolic acid (QD 4) and mercapto-propanoic acid-thiol-glycolic (QD 5). Dual-capped CdTe QDs were prepared using a one pot synthetic method. Cadmium acetate and sodium tellurite were respectively used as cadmium and tellurium precursors. Photo-physical properties of the synthesized QDs were examined using UV-Vis and photoluminescence spectroscopy while structural characterization was performed by means of transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectroscopy.
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  • Date Issued: 2020

Synthesis, characterization and biological activity of some Dithiourea Derivatives:

Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic Arylpyrrole-Based Chalcone derivatives:

  • Authors: Zulu, Ayanda I , Oderinlo, Ogunyemi O , Kruger, Cuan , Isaacs, Michelle , Hoppe, Heinrich C , Smith, Vincent J , Veale, Clinton G L , Khanye, Setshaba D
  • Date: 2020
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/179017 , vital:40096 , https://doi.org/10.3390/molecules25071668
  • Description: With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields. The resultant compounds were evaluated in vitro for their potential activity against a cultured Trypanosoma brucei brucei 427 strain. Several compounds displayed mostly modest in vitro anti-trypanosomal activity with compounds 10e and 10h emerging as active candidates with IC50 values of 4.09 and 5.11 µM, respectively. More importantly, a concomitant assessment of their activity against a human cervix adenocarcinoma (HeLa) cell line revealed that these compounds are non-toxic.
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  • Date Issued: 2020

Synthetic, characterization and cytotoxic studies of ruthenium complexes with Schiff bases encompassing biologically relevant moieties:

  • Authors: Maikoo, Sanam , Dingle, Laura M K , Chakraborty, Abir , Xulu, Bheki , Edkins, Adrienne L , Booysen, Irvin N
  • Date: 2020
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/165429 , vital:41243 , https://doi.org/10.1016/j.poly.2020.114569
  • Description: This research study describes the formation and characterization of novel paramagnetic ruthenium complexes, cis-Cl, trans-P-[RuIIICl2(carboim)(PPh3)2] with bidentate chelating carbohydrazide Schiff bases (carboim = bpc for 1, ttc for 2 and tpc for 3). These metal complexes were synthesized by the equimolar coordination reactions of trans-[RuCl2(PPh3)2] with N-[1,3-benzothiazole-2-ylmethylidene]pyridine-2-carbohydrazide (Hbpc), N-((uracil-5-yl)methylene)thiophene-2-carbohydrazide (Httc) and N-[(uracil-5-yl)methylidene]pyridine-2-carbohydrazide (Htpc), respectively. Physicochemical techniques including nuclear magnetic resonance-, electron-spin resonance- and infrared spectroscopy, UV–Vis spectrophotometry, voltammetry as well as molar conductivity measurements provided definitive determinations of the respective ruthenium compounds’ structures.
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  • Date Issued: 2020

Temperature tolerance and humidity requirements of select entomopathogenic fungal isolates for future use in citrus IPM programmes

  • Authors: Acheampong, M A , Coombes, Candice A , Moore, Sean D , Hill, Martin P
  • Date: 2020
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/419399 , vital:71641 , xlink:href="https://doi.org/10.1016/j.jip.2020.107436"
  • Description: Several isolates of Beauveria bassiana (Balsamo-Crivelli) Vuillemin (Hypocreales: Cordycipitacae) and Metarhizium anisopliae (Metchnikoff) Sorokin (Hypocreales: Clavicipitacae) have been investigated as possible microbial control agents of key citrus pests in South Africa. Although laboratory results have been promising, field trials against foliar pests have shown limited success. These findings highlighted the need to investigate other biological attributes of these fungal isolates besides virulence in order to select candidates that may be better suited for the foliar environment. Thus, this study investigated the influence of temperature on the in vitro growth of seven indigenous local isolates and the humidity requirements necessary to promote successful infection, in comparison with two commercial isolates (B. bassiana PPRI 5339 and M. anisopliae ICIPE 69). All the fungal isolates grew across a range of temperatures (8–34 °C) and optimally between 26 and 28 °C. Similarly, fungal infection of Thaumatotibia leucotreta Meyrick (Lepidoptera: Tortricidae) fifth instars occurred across a range of humidity levels (12%, 43%, 75%, 98%) regardless of fungal concentration, although external sporulation was restricted to treatments exposed to 98% relative humidity. It was concluded that neither temperature nor humidity, when considered alone, is likely to significantly influence the efficacy of any of the isolates in the field, given that they are active within temperature and humidity ranges experienced in South African citrus orchards.
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  • Date Issued: 2020

The alternative theory of state-minded protest texts in the music of democratic Nigeria:

  • Authors: Osiebe, Garhe
  • Date: 2020
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/160423 , vital:40444 , DOI: 10.1080/21681392.2020.1810085
  • Description: This paper centres on an alternative discourse of popular music culture in re-democratized Nigeria. Whereas much work has been done on state-minded protest music in Nigeria, studies have been reticent in appreciating the works of Fela's son, Femi; particularly within a framework of re-democratized Nigeria's equivalent of Fela's works which constituted a major alternative voice through military-ruled Nigeria. The paper is an attempt to make up this lacuna along the lines of Chris Atton’s 2006 alternative media theory. The analysis of the alternative media theory is complemented by an analysis of the texts of selected state-minded protest works from two crossover popular musicians – Blackface and Mr Raw – of re-democratized Nigeria, both of whose state-minded protest works have hitherto been unexplored by the academe.
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  • Date Issued: 2020

The association between HIV tri-therapy with the development of Type-2 Diabetes Mellitus in a rural South African district: A case-control study

  • Authors: Bam, Nokwanda E , Mabunda, Sikhumbuzo A , Ntsaba, Jafta , Apalata, Teke , Monatshila, Sibusisu C , Chitha, Wesile
  • Date: 2020
  • Subjects: Type 2 diabetes , AIDS (Disease) , Rural health
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/11260/4008 , vital:43983 , https://doi.org/10.1371/journal.pone.0244067
  • Description: Combination antiretroviral drugs(cARVs)prolong patients’ lives but are unfortunately thought to increase complications related to metabolic disorders including type-2 Diabetes Mellitus(DM).We sought to confirm the association of cARVs with type-2DM and ascertain the extent of this association in a rural South African setting. A case-control study of 177 (33.33%) cases with HIV/AIDS and type-2 DM were selected and compared with 354 (66.67%) non-DM HIV/AIDS unmatched controls from a rural district of South Africa’s third most populous province (Eastern Cape). Cases were identified from community health centres using the district health information system, and controls were identified using simple random sampling from the same health facilities. Odds Ratios (OR), together with 95% confidence intervals, were calculated for all the univariable and multivariable logistic analyses. This study found that cARVs significantly increased the occurrence of type-2 DM among HIV patients. Patients on protease inhibitors (PIs) were at least 21 times significantly more likely to be diabetic than those on the fixed dose combination (FDC); those on stavudine (D4T) and zidovudine (AZT) were 2.45 times and 9.44 times respectively more likely to be diabetic than those on FDC. The odds of diabetes increased by more than three-folds for those who had been on antiretroviral drugs for more than 6 years.
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  • Date Issued: 2020

The crystal structure of 2-oxo-2H-chromen-4-yl acetate, C11H8O4

  • Authors: Hulushe, Siya T , Manyeruke, Meloddy H , Hosten, Eric C , Kaye, Perry , Watkins, Gareth M
  • Date: 2020
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/194048 , vital:45418 , xlink:href="https://doi.org/10.1515/ncrs-2019-0698"
  • Description: C11H8O4, monoclinic, P21/c (no. 14), a = 4.5947(2) Å, b = 10.5414(3) Å, c = 19.1611(7) Å, β = 94.084(2)°, V = 925.70(6) Å3, Z = 4, Rgt(F) = 0.0376, wRref(F 2) = 0.1109,T = 200(2) K.CCDC no.: 1906383
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  • Date Issued: 2020
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