A drug utilisation review of lithium at a public sector psychiatric hospital
- Authors: Mapfumo, Charlotte
- Date: 2020-04
- Subjects: Lithium -- Therapeutic use , Psychiatric hospitals -- South Africa -- Grahamstown , Drug utilization , Psychiatric hospital care , Manic-depressive illness , Lithium -- Toxicology , Drug monitoring
- Language: English
- Type: text , Thesis , Masters , M.Pharm
- Identifier: http://hdl.handle.net/10962/150541 , vital:38983
- Description: Bipolar disorder (BD) is a common mental condition that affects about 60 million people globally. Lithium is among the drugs of choice used to treat BD and other affective disorders such as schizoaffective disorder (SD). Lithium is a mood stabiliser with antimanic, antidepressant and anti-suicidal properties. Lithium has complex mechanisms of action and a narrow therapeutic index (NTI). Therapeutic drug monitoring (TDM) is a vital component of lithium therapy due to its NTI. Lithium toxicity can occur at therapeutic levels and is characterised by symptoms such as blurred vision and convulsions. Lithium interacts with a number of drugs resulting in lithium toxicity or diminished effects of lithium. Symptoms of lithium toxicity range from abdominal pain, convulsions and death. Lithium use is associated with serious adverse effects on renal and thyroid function. Other adverse effects include tremor and weight gain. Monitoring of lithium serum levels, renal and thyroid function are therefore recommended for patients on lithium therapy. Monitoring of these parameters assists in the early detection of any problems associated with lithium use. The metabolic monitoring of lithium is vital due to the adverse effect profile of lithium and the current South African Standard Treatment Guidelines Hospital level: Adults, do not have any recommendations for the monitoring of metabolic parameters. The National Institute for Health and Care Excellence (NICE) may be used and adapted for the South African setting. Aim and Objectives: The general aim of the study was to conduct a drug utilisation review (DUR) on lithium through investigating its prescribing and monitoring patterns in both inpatients and outpatients at Fort England Hospital. Methodology: The study was in the form of a retrospective DUR. Data was collected from 40 files (n=40) of patients who were on treatment with lithium between 1 January 2017-31 December 2017 at Fort England Hospital. The data was collected retrospectively for both in- and outpatients. Compliance of the monitoring requirements with both South African and international guidelines was analysed. Results and Discussion: In 87.50% (n=37) of the cases, patients had been on lithium therapy before 2017 with most patients (n=13; 37.50%) being maintained on 500 mg of lithium. Non-compliance with the South African and NICE guidelines for renal baseline monitoring was 65.00% (n=26) in both guidelines. Non-compliance for baseline thyroid monitoring was 70.00% (n=28) for both guidelines. There was non-compliance in 45.00% (n=18) of the cases for lithium serum level monitoring for both guidelines. Non-compliance with follow-up renal monitoring was 47.50% (n=19) for both guidelines. Compliance with the NICE guidelines for follow-up metabolic monitoring was 67.50% (n=27). Conclusion: There was non-compliance in most cases leaving room for clinical improvement in the monitoring of lithium. Healthcare professionals should be educated on the recommended monitoring guidelines to promote the rational use of lithium in South Africa. Pharmacists should be more involved in the TDM of lithium to promote its safe and effective use.
- Full Text:
- Date Issued: 2020-04
- Authors: Mapfumo, Charlotte
- Date: 2020-04
- Subjects: Lithium -- Therapeutic use , Psychiatric hospitals -- South Africa -- Grahamstown , Drug utilization , Psychiatric hospital care , Manic-depressive illness , Lithium -- Toxicology , Drug monitoring
- Language: English
- Type: text , Thesis , Masters , M.Pharm
- Identifier: http://hdl.handle.net/10962/150541 , vital:38983
- Description: Bipolar disorder (BD) is a common mental condition that affects about 60 million people globally. Lithium is among the drugs of choice used to treat BD and other affective disorders such as schizoaffective disorder (SD). Lithium is a mood stabiliser with antimanic, antidepressant and anti-suicidal properties. Lithium has complex mechanisms of action and a narrow therapeutic index (NTI). Therapeutic drug monitoring (TDM) is a vital component of lithium therapy due to its NTI. Lithium toxicity can occur at therapeutic levels and is characterised by symptoms such as blurred vision and convulsions. Lithium interacts with a number of drugs resulting in lithium toxicity or diminished effects of lithium. Symptoms of lithium toxicity range from abdominal pain, convulsions and death. Lithium use is associated with serious adverse effects on renal and thyroid function. Other adverse effects include tremor and weight gain. Monitoring of lithium serum levels, renal and thyroid function are therefore recommended for patients on lithium therapy. Monitoring of these parameters assists in the early detection of any problems associated with lithium use. The metabolic monitoring of lithium is vital due to the adverse effect profile of lithium and the current South African Standard Treatment Guidelines Hospital level: Adults, do not have any recommendations for the monitoring of metabolic parameters. The National Institute for Health and Care Excellence (NICE) may be used and adapted for the South African setting. Aim and Objectives: The general aim of the study was to conduct a drug utilisation review (DUR) on lithium through investigating its prescribing and monitoring patterns in both inpatients and outpatients at Fort England Hospital. Methodology: The study was in the form of a retrospective DUR. Data was collected from 40 files (n=40) of patients who were on treatment with lithium between 1 January 2017-31 December 2017 at Fort England Hospital. The data was collected retrospectively for both in- and outpatients. Compliance of the monitoring requirements with both South African and international guidelines was analysed. Results and Discussion: In 87.50% (n=37) of the cases, patients had been on lithium therapy before 2017 with most patients (n=13; 37.50%) being maintained on 500 mg of lithium. Non-compliance with the South African and NICE guidelines for renal baseline monitoring was 65.00% (n=26) in both guidelines. Non-compliance for baseline thyroid monitoring was 70.00% (n=28) for both guidelines. There was non-compliance in 45.00% (n=18) of the cases for lithium serum level monitoring for both guidelines. Non-compliance with follow-up renal monitoring was 47.50% (n=19) for both guidelines. Compliance with the NICE guidelines for follow-up metabolic monitoring was 67.50% (n=27). Conclusion: There was non-compliance in most cases leaving room for clinical improvement in the monitoring of lithium. Healthcare professionals should be educated on the recommended monitoring guidelines to promote the rational use of lithium in South Africa. Pharmacists should be more involved in the TDM of lithium to promote its safe and effective use.
- Full Text:
- Date Issued: 2020-04
Application of quality by design to the manufacture of a multiparticulate prednisone dosage form
- Authors: Manda, Arthur
- Date: 2020-04
- Subjects: Drugs -- Quality control , Drugs -- Design -- Quality control , Drugs -- Dosage forms , Drug development -- Quality control , Pharmaceutical industry -- Quality control , Prednisone , High throughput screening (Drug development)
- Language: English
- Type: text , Thesis , Masters , MSc (Pharmacy)
- Identifier: http://hdl.handle.net/10962/117986 , vital:34583
- Description: For many years, quality by testing was the only approach to guarantee quality of drug products before the Food and Drug Administration launched the concept of current Good Manufacturing Practice. In order to gain more knowledge of the manufacturing process, a new system known as Quality by Design was introduced into the pharmaceutical industry. Quality by Design is based on thorough understanding of how materials, process parameters and interaction thereof impact final product quality. Quality by Design is a systematic approach to product development which ensures that quality is built into a product during product development and not just tested into it. The aim of Quality by Design is to achieve optimum product quality with consistent dosage form performance and minimal risk of failure in patients. The objective of these studies was to implement a Quality by Design approach to establish a design space for the development and manufacture of a safe, effective and stable multi-partite solid oral dosage form for prednisone as an alternative to currently marketed prednisone formulations. Multi-particulate dosage forms offer significant advantages over conventional technologies. In addition to lowering the incidence of gastrointestinal irritation they exhibit a reduced risk of dose dumping and a large surface area which favours dissolution. Furthermore, their free flowing nature facilitates reproducible capsule filling and consequently uniformity of dosing. Different multi-particulate dosage forms exist however a multiple-unit pellet system was investigated during these studies. Quality by Design principles were used to develop and establish a reversed-phase high performance liquid chromatographic method for quantifying prednisone from solid oral dosage forms. A Central Composite Design was used to generate multivariate experiments and to investigate the impact of input variables on the quality and performance of the analytical method. The optimized method was validated according to International Council for Harmonization guidelines and was found to be linear, precise, accurate and specific for the quantitation of prednisone. Pre-formulation studies were conducted and included the assessment of particle size, particle shape, powder flow properties and compatibility studies. Carr’s index, Hausner ratio and the Angle of Repose were used to evaluate powder flow properties and results generated from all studies suggest the need for adding a glidant and lubricant to improve pellet flow. The images generated from Scanning Electron Microscopy were used to analyze particle shape and size. Differential Scanning Calorimetry and Fourier Transform Infrared Spectroscopy were used to evaluate API-excipient compatibility. All excipients investigated were found to be compatible with prednisone and suitable for formulation development studies. Extrusion-spheronization was used to manufacture prednisone pellets. Extrusion-spheronization is a multi-step process involving many factors. Quality risk management tools particularly an Ishikawa Fishbone (cause and effect) diagram and failure mode and effects analysis were used to narrow down potentially significant factors to a reasonable number that could be investigated experimentally. Risk priority numbers were used to quantify risk and factors above a set threshold value were considered to be of high risk. A total of eleven risk factors were identified as high. A Plackett-Burman study was conducted to narrow down the eleven high risk factors to identify the most impactful factors viz., microcrystalline cellulose content, sodium starch glycolate content, extrusion speed and spheronization time. Evaluation of four factors was carried over to optimization studies using a Box-Behnken Design and following identifaction of the optimum process settings and excipient content a design space for the manufacture of a multi-partite dosage form containing prednisone was established.
- Full Text:
- Date Issued: 2020-04
- Authors: Manda, Arthur
- Date: 2020-04
- Subjects: Drugs -- Quality control , Drugs -- Design -- Quality control , Drugs -- Dosage forms , Drug development -- Quality control , Pharmaceutical industry -- Quality control , Prednisone , High throughput screening (Drug development)
- Language: English
- Type: text , Thesis , Masters , MSc (Pharmacy)
- Identifier: http://hdl.handle.net/10962/117986 , vital:34583
- Description: For many years, quality by testing was the only approach to guarantee quality of drug products before the Food and Drug Administration launched the concept of current Good Manufacturing Practice. In order to gain more knowledge of the manufacturing process, a new system known as Quality by Design was introduced into the pharmaceutical industry. Quality by Design is based on thorough understanding of how materials, process parameters and interaction thereof impact final product quality. Quality by Design is a systematic approach to product development which ensures that quality is built into a product during product development and not just tested into it. The aim of Quality by Design is to achieve optimum product quality with consistent dosage form performance and minimal risk of failure in patients. The objective of these studies was to implement a Quality by Design approach to establish a design space for the development and manufacture of a safe, effective and stable multi-partite solid oral dosage form for prednisone as an alternative to currently marketed prednisone formulations. Multi-particulate dosage forms offer significant advantages over conventional technologies. In addition to lowering the incidence of gastrointestinal irritation they exhibit a reduced risk of dose dumping and a large surface area which favours dissolution. Furthermore, their free flowing nature facilitates reproducible capsule filling and consequently uniformity of dosing. Different multi-particulate dosage forms exist however a multiple-unit pellet system was investigated during these studies. Quality by Design principles were used to develop and establish a reversed-phase high performance liquid chromatographic method for quantifying prednisone from solid oral dosage forms. A Central Composite Design was used to generate multivariate experiments and to investigate the impact of input variables on the quality and performance of the analytical method. The optimized method was validated according to International Council for Harmonization guidelines and was found to be linear, precise, accurate and specific for the quantitation of prednisone. Pre-formulation studies were conducted and included the assessment of particle size, particle shape, powder flow properties and compatibility studies. Carr’s index, Hausner ratio and the Angle of Repose were used to evaluate powder flow properties and results generated from all studies suggest the need for adding a glidant and lubricant to improve pellet flow. The images generated from Scanning Electron Microscopy were used to analyze particle shape and size. Differential Scanning Calorimetry and Fourier Transform Infrared Spectroscopy were used to evaluate API-excipient compatibility. All excipients investigated were found to be compatible with prednisone and suitable for formulation development studies. Extrusion-spheronization was used to manufacture prednisone pellets. Extrusion-spheronization is a multi-step process involving many factors. Quality risk management tools particularly an Ishikawa Fishbone (cause and effect) diagram and failure mode and effects analysis were used to narrow down potentially significant factors to a reasonable number that could be investigated experimentally. Risk priority numbers were used to quantify risk and factors above a set threshold value were considered to be of high risk. A total of eleven risk factors were identified as high. A Plackett-Burman study was conducted to narrow down the eleven high risk factors to identify the most impactful factors viz., microcrystalline cellulose content, sodium starch glycolate content, extrusion speed and spheronization time. Evaluation of four factors was carried over to optimization studies using a Box-Behnken Design and following identifaction of the optimum process settings and excipient content a design space for the manufacture of a multi-partite dosage form containing prednisone was established.
- Full Text:
- Date Issued: 2020-04
Evaluating the prescribing and management practices of clozapine at a public sector psychiatric hospital
- Authors: Mukoko, Vimbisai Millicent
- Date: 2020-04
- Subjects: Clozapine , Schizophrenia -- Chemotherapy , Schizophrenia -- South Africa -- Treatment
- Language: English
- Type: text , Thesis , Masters , M.Pharm
- Identifier: http://hdl.handle.net/10962/123266 , vital:35422
- Description: Approximately one percent (1%) of the South African population suffers from schizophrenia. Clozapine has proven to be more effective than conventional antipsychotics in the treatment of schizophrenia, particularly in alleviating positive symptoms. Clozapine is primarily indicated for treatment-resistant schizophrenia due to its severe adverse effect profile. The prescribing guidelines recommend a trial of at least two different antipsychotic drugs before the initiation of clozapine. At least one should be a non-clozapine second generation antipsychotic. Compared to other atypical antipsychotics, clozapine poses the greatest risk of causing a haematological event, such as neutropenia and agranulocytosis. Agranulocytosis (estimated prevalence of 1.3%) is a life-threatening adverse effect. Common adverse effects include weight gain and metabolic syndrome, hypersalivation and constipation. These can also predispose the patient to co-morbid diseases which further complicate their current diagnosis. Haematological and metabolic monitoring is paramount throughout the duration of clozapine therapy. International (NICE guidelines, Clozapine REMS, and Maudsley prescribing guidelines) and national (South African STGs, SASOP treatment guidelines and the SAMF) guidelines recommend these monitoring patterns to assist with the prevention and management of the adverse effects of clozapine.
- Full Text:
- Date Issued: 2020-04
- Authors: Mukoko, Vimbisai Millicent
- Date: 2020-04
- Subjects: Clozapine , Schizophrenia -- Chemotherapy , Schizophrenia -- South Africa -- Treatment
- Language: English
- Type: text , Thesis , Masters , M.Pharm
- Identifier: http://hdl.handle.net/10962/123266 , vital:35422
- Description: Approximately one percent (1%) of the South African population suffers from schizophrenia. Clozapine has proven to be more effective than conventional antipsychotics in the treatment of schizophrenia, particularly in alleviating positive symptoms. Clozapine is primarily indicated for treatment-resistant schizophrenia due to its severe adverse effect profile. The prescribing guidelines recommend a trial of at least two different antipsychotic drugs before the initiation of clozapine. At least one should be a non-clozapine second generation antipsychotic. Compared to other atypical antipsychotics, clozapine poses the greatest risk of causing a haematological event, such as neutropenia and agranulocytosis. Agranulocytosis (estimated prevalence of 1.3%) is a life-threatening adverse effect. Common adverse effects include weight gain and metabolic syndrome, hypersalivation and constipation. These can also predispose the patient to co-morbid diseases which further complicate their current diagnosis. Haematological and metabolic monitoring is paramount throughout the duration of clozapine therapy. International (NICE guidelines, Clozapine REMS, and Maudsley prescribing guidelines) and national (South African STGs, SASOP treatment guidelines and the SAMF) guidelines recommend these monitoring patterns to assist with the prevention and management of the adverse effects of clozapine.
- Full Text:
- Date Issued: 2020-04
Evaluating the prescribing and management practices of venlafaxine at a public sector psychiatric hospital
- Authors: Naidu, Bavika
- Date: 2020-04
- Subjects: Venlafaxine , Anxiety disorcers -- Treatment , Depression, Mental -- Treatment
- Language: English
- Type: text , Thesis , Masters , M.Pharm
- Identifier: http://hdl.handle.net/10962/123200 , vital:35414
- Description: Neuropsychiatric conditions have been ranked third in South Africa according to some of the most recent reviews of disease burden, following human immunodeficiency virus/acquired immune deficiency syndrome and other infectious diseases (Bateman, 2012:70; South African Depression and Anxiety Group, 2018). For depressive disorders, the conventional selective serotonin reuptake inhibitors (e.g. fluoxetine), are common first-step treatments due to their relatively low toxicity and high tolerability (Rush et al., 2006:1231). The class of selective noradrenaline reuptake inhibitors (e.g. venlafaxine) is relatively new on the market. The first SNRI to be marketed in the United States was venlafaxine immediate-release (IR). It was approved by the United States FDA in 1993 (Sansone and Sansone, 2014:37) and was soon followed by the introduction of a micro-encapsulated extended-release (XR) formulation in 1997. Currently there is no published or readily available information concerning the prescribing and management patterns of venlafaxine as well as the incidence and types of adverse effects experienced by patients in the public health sector of South Africa besides the established increased in blood pressure.
- Full Text:
- Date Issued: 2020-04
- Authors: Naidu, Bavika
- Date: 2020-04
- Subjects: Venlafaxine , Anxiety disorcers -- Treatment , Depression, Mental -- Treatment
- Language: English
- Type: text , Thesis , Masters , M.Pharm
- Identifier: http://hdl.handle.net/10962/123200 , vital:35414
- Description: Neuropsychiatric conditions have been ranked third in South Africa according to some of the most recent reviews of disease burden, following human immunodeficiency virus/acquired immune deficiency syndrome and other infectious diseases (Bateman, 2012:70; South African Depression and Anxiety Group, 2018). For depressive disorders, the conventional selective serotonin reuptake inhibitors (e.g. fluoxetine), are common first-step treatments due to their relatively low toxicity and high tolerability (Rush et al., 2006:1231). The class of selective noradrenaline reuptake inhibitors (e.g. venlafaxine) is relatively new on the market. The first SNRI to be marketed in the United States was venlafaxine immediate-release (IR). It was approved by the United States FDA in 1993 (Sansone and Sansone, 2014:37) and was soon followed by the introduction of a micro-encapsulated extended-release (XR) formulation in 1997. Currently there is no published or readily available information concerning the prescribing and management patterns of venlafaxine as well as the incidence and types of adverse effects experienced by patients in the public health sector of South Africa besides the established increased in blood pressure.
- Full Text:
- Date Issued: 2020-04
Preparation, characterization and optimization of carbamazepine based pellets prepared by extrusion-spheronization technique
- Authors: Makoni, Kudzai Gabriella
- Date: 2020-04
- Subjects: Carbamazepine , Pharmacokinetics , Anticonvulsants , Drugs -- Controlled release , Drugs -- Dosage forms , Tablets (Medicine) , Drugs -- Administration , High performance liquid chromatography , International Conference on Harmonisation , Experimental design
- Language: English
- Type: Thesis , Masters , MSc (Pharmacy)
- Identifier: http://hdl.handle.net/10962/140478 , vital:37893
- Description: Carbamazepine (CBZ) is an oral antiepileptic drug (AED) that is prescribed as a first-line treatment for partial seizures. CBZ is a class II compound according to the Biopharmaceutical Classification System (BCS), hence it exhibits low aqueous solubility and high gastrointestinal tract (GIT) permeability...
- Full Text:
- Date Issued: 2020-04
- Authors: Makoni, Kudzai Gabriella
- Date: 2020-04
- Subjects: Carbamazepine , Pharmacokinetics , Anticonvulsants , Drugs -- Controlled release , Drugs -- Dosage forms , Tablets (Medicine) , Drugs -- Administration , High performance liquid chromatography , International Conference on Harmonisation , Experimental design
- Language: English
- Type: Thesis , Masters , MSc (Pharmacy)
- Identifier: http://hdl.handle.net/10962/140478 , vital:37893
- Description: Carbamazepine (CBZ) is an oral antiepileptic drug (AED) that is prescribed as a first-line treatment for partial seizures. CBZ is a class II compound according to the Biopharmaceutical Classification System (BCS), hence it exhibits low aqueous solubility and high gastrointestinal tract (GIT) permeability...
- Full Text:
- Date Issued: 2020-04
Productive Heterotopias as a Conceptual Basis for the Design of Sustainable Low-Income Housing within the Cape Town Inner-City
- Authors: Van Niekerk, Neil
- Date: 2020-04
- Subjects: Productive life span , Low-income housing -- Cape town -- City
- Language: English
- Type: Master's theses , Thesis
- Identifier: http://hdl.handle.net/10948/58805 , vital:60123
- Description: Lasting colonial and patriarchal spatial strategies have resulted in South African cities characterised by vast inequalities and unsustainable patterns of development. These include explosive low-density sprawl, fragmentation, separation and a city-wide pattern of core and periphery. Housing justice for the urban poor is a critical component in addressing this, however, numerous studies have found that low-income housing projects have in the majority of cases ended up perpetuating these socially, economically and environmentally unsustainable patterns of development and reinforcing existing spatial injustices. For this reason, design research into more sustainable and productive architectural design strategies for low-income housing appropriate to the South African urban context is particularly important and forms the central concern of this treatise. To be more specific, this study questions how the theoretical idea of productive heterotopias and reimagining the role of the architect as that of a spatial agent could be used to generate a practical low-income housing strategy for a site in the Cape Town inner-city – one that is socially, economically and environmentally sustainable. To achieve this, a critical theoretical lens was adopted in conducting the research and a range of open-ended qualitative research methods were employed to gather, analyse and synthesise data. Because of its particular appropriateness to design research, data analysis primarily relied on abductive reasoning. This study is valuable in that it provides an exploration into the application of critical theory to low-income housing design in South African cities and demonstrates the architectural understandings gained within a set of design scenarios and architectural prototypes. This study argues that any low-income housing strategy in South Africa needs to recognise the complexities of the housing process, make use of time as an important building material and advance the right to the city of the urban poor, i.e. finding a balance between structure and agency that allows greater freedom for ordinary people to have a hand in co-creating the city through spontaneity, improvisation and incremental development, for that strategy to be truly sustainable and productive, as well as to assist in cultivating positively performing and equitable urban environments. In particular, this study rejects the top-down housing methods employed within mainstream development practice in favour of finding an alternative approach that will result in a more supportive housing project. Finding this new supportive approach involved investigating co-operative forms of organisation, methods for allowing community participation, sustainable building materials, simple construction methods and incorporating urban farming as a strategy for supplementing income. Additionally, this study argues that the chosen site for the design, namely Harrington Square, functions as a public urban square at the centre of a larger shared space while simultaneously supporting the proposed housing intervention. , Thesis (MA) -- Faculty - School of of Architecture, 2020
- Full Text:
- Date Issued: 2020-04
- Authors: Van Niekerk, Neil
- Date: 2020-04
- Subjects: Productive life span , Low-income housing -- Cape town -- City
- Language: English
- Type: Master's theses , Thesis
- Identifier: http://hdl.handle.net/10948/58805 , vital:60123
- Description: Lasting colonial and patriarchal spatial strategies have resulted in South African cities characterised by vast inequalities and unsustainable patterns of development. These include explosive low-density sprawl, fragmentation, separation and a city-wide pattern of core and periphery. Housing justice for the urban poor is a critical component in addressing this, however, numerous studies have found that low-income housing projects have in the majority of cases ended up perpetuating these socially, economically and environmentally unsustainable patterns of development and reinforcing existing spatial injustices. For this reason, design research into more sustainable and productive architectural design strategies for low-income housing appropriate to the South African urban context is particularly important and forms the central concern of this treatise. To be more specific, this study questions how the theoretical idea of productive heterotopias and reimagining the role of the architect as that of a spatial agent could be used to generate a practical low-income housing strategy for a site in the Cape Town inner-city – one that is socially, economically and environmentally sustainable. To achieve this, a critical theoretical lens was adopted in conducting the research and a range of open-ended qualitative research methods were employed to gather, analyse and synthesise data. Because of its particular appropriateness to design research, data analysis primarily relied on abductive reasoning. This study is valuable in that it provides an exploration into the application of critical theory to low-income housing design in South African cities and demonstrates the architectural understandings gained within a set of design scenarios and architectural prototypes. This study argues that any low-income housing strategy in South Africa needs to recognise the complexities of the housing process, make use of time as an important building material and advance the right to the city of the urban poor, i.e. finding a balance between structure and agency that allows greater freedom for ordinary people to have a hand in co-creating the city through spontaneity, improvisation and incremental development, for that strategy to be truly sustainable and productive, as well as to assist in cultivating positively performing and equitable urban environments. In particular, this study rejects the top-down housing methods employed within mainstream development practice in favour of finding an alternative approach that will result in a more supportive housing project. Finding this new supportive approach involved investigating co-operative forms of organisation, methods for allowing community participation, sustainable building materials, simple construction methods and incorporating urban farming as a strategy for supplementing income. Additionally, this study argues that the chosen site for the design, namely Harrington Square, functions as a public urban square at the centre of a larger shared space while simultaneously supporting the proposed housing intervention. , Thesis (MA) -- Faculty - School of of Architecture, 2020
- Full Text:
- Date Issued: 2020-04
Science engagement with school learners for microbial quality testing of water in Makhanda
- Authors: Nqowana, Thandiswa
- Date: 2020-04
- Language: English
- Type: text , Thesis , Masters , MSc (Pharmacy)
- Identifier: http://hdl.handle.net/10962/124754 , vital:35677
- Description: Expected release date-April 2022
- Full Text: false
- Date Issued: 2020-04
- Authors: Nqowana, Thandiswa
- Date: 2020-04
- Language: English
- Type: text , Thesis , Masters , MSc (Pharmacy)
- Identifier: http://hdl.handle.net/10962/124754 , vital:35677
- Description: Expected release date-April 2022
- Full Text: false
- Date Issued: 2020-04
The design of a hydrotherapy facility in Mangolds pool resort: biophilic principles in the design of therapeutic environments
- Authors: Vos, Charne’
- Date: 2020-04
- Subjects: Hydrotherapy , Therapeutic communities
- Language: English
- Type: Master's theses , Thesis
- Identifier: http://hdl.handle.net/10948/58761 , vital:60092
- Description: Abstract In the quest for achieving a modern civilization, the interconnected relationship between man and nature has changed to one of disconnection. This disconnection between built and natural environments leads to the deterioration of the physiological and psychological health and well-being of man. (Spaargaren & Mol, 1992) By analyzing healing environments over a lifetime, a better understanding can be formed as to what the ideal relationship should be for stimulating well-being in an ever changing modern society. Based on this, an attempt will be made to redefine this relationship. Since early antiquity water has been considered vital for both sustenance as well as the birth and development of civilizations. Man soon discovered its importance and beneficial properties in terms of healing and prevention. (Juuti et al. 2012). Such ancient wisdom can be adopted today and help improve our level of public health. For this reason, the proposed program is a hydrotherapy facility that focuses on the relation between the natural and built environment. The aim of this treatise is to examine how architecture can be a device that heals humans who have been compromised by their environment. The idea that a building can induce healing derives from the concept of Therapeutic Architecture, which explores various theories and principles such as Biophilic design, salutogenic design and Phenomenology. These concepts focus on the therapeutic qualities of the environment, which will be investigated to create a basis for the theoretical framework and play an integral part in design. , Thesis (MA) -- Faculty - School of Architecture, 2020
- Full Text:
- Date Issued: 2020-04
- Authors: Vos, Charne’
- Date: 2020-04
- Subjects: Hydrotherapy , Therapeutic communities
- Language: English
- Type: Master's theses , Thesis
- Identifier: http://hdl.handle.net/10948/58761 , vital:60092
- Description: Abstract In the quest for achieving a modern civilization, the interconnected relationship between man and nature has changed to one of disconnection. This disconnection between built and natural environments leads to the deterioration of the physiological and psychological health and well-being of man. (Spaargaren & Mol, 1992) By analyzing healing environments over a lifetime, a better understanding can be formed as to what the ideal relationship should be for stimulating well-being in an ever changing modern society. Based on this, an attempt will be made to redefine this relationship. Since early antiquity water has been considered vital for both sustenance as well as the birth and development of civilizations. Man soon discovered its importance and beneficial properties in terms of healing and prevention. (Juuti et al. 2012). Such ancient wisdom can be adopted today and help improve our level of public health. For this reason, the proposed program is a hydrotherapy facility that focuses on the relation between the natural and built environment. The aim of this treatise is to examine how architecture can be a device that heals humans who have been compromised by their environment. The idea that a building can induce healing derives from the concept of Therapeutic Architecture, which explores various theories and principles such as Biophilic design, salutogenic design and Phenomenology. These concepts focus on the therapeutic qualities of the environment, which will be investigated to create a basis for the theoretical framework and play an integral part in design. , Thesis (MA) -- Faculty - School of Architecture, 2020
- Full Text:
- Date Issued: 2020-04
The design of a waste recycling facility for the waste pickers of Arlington landfill, Port Elizabeth: recognising the needs of unacknowledged stakeholders in the circular waste economy
- Authors: Smit, Blake Sean
- Date: 2020-04
- Subjects: Recycling (Waste, etc.)--Arlington landfill -- Port Elizabeth , stakeholder management
- Language: English
- Type: Master's theses , Thesis
- Identifier: http://hdl.handle.net/10948/58609 , vital:59958
- Description: At this very moment, this very second, in the backstreets and upon high, vast wastelands, something is in motion. Often on the periphery of our daily thoughts, or not at all, this very motion never ceases to exist- it simply cannot afford to. Waste, our modern-day global issue, has reached a critical point, causing us to now venture into uncharted territories. We produce unspeakable amounts of waste per annum creating compounding social and environmental problems, and in the process we create a partic - ular physical object, an altered landscape known as a landfill. The landfill environment is where this treatise chooses to position itself but looks further into the existing community of individuals who perform the task of recycling. Waste pickers, an unmatched motion and dynamic within our broad waste landscape, remain largely unacknowledged in the role they play in the circular waste economy, subsequently creating the core concern for this treatise. Hence, the building type responsible, a waste recycling facility, that looks to identify and address the needs that these individuals require to safely carry out their pivotal role within the setting of Arlington Landfill in Port Elizabeth. Therefore, this treatise looks to uncover and bring to light a day in the life of a waste picker, through an architectural intervention seeking to become more than an object on the landscape. The treatise looks to break away from a static architectural object by applying the overall lens guided by ‘Anti-Object’ writ - ten by Kengo Kuma, therefore concerning itself with an overarching process of creating an emerging anti-object architecture, embodying the subtitles and characteristics of the waste pickers of Arlington Landfill. , Thesis (MA) -- Faculty - School of Architecture, 2020
- Full Text:
- Date Issued: 2020-04
- Authors: Smit, Blake Sean
- Date: 2020-04
- Subjects: Recycling (Waste, etc.)--Arlington landfill -- Port Elizabeth , stakeholder management
- Language: English
- Type: Master's theses , Thesis
- Identifier: http://hdl.handle.net/10948/58609 , vital:59958
- Description: At this very moment, this very second, in the backstreets and upon high, vast wastelands, something is in motion. Often on the periphery of our daily thoughts, or not at all, this very motion never ceases to exist- it simply cannot afford to. Waste, our modern-day global issue, has reached a critical point, causing us to now venture into uncharted territories. We produce unspeakable amounts of waste per annum creating compounding social and environmental problems, and in the process we create a partic - ular physical object, an altered landscape known as a landfill. The landfill environment is where this treatise chooses to position itself but looks further into the existing community of individuals who perform the task of recycling. Waste pickers, an unmatched motion and dynamic within our broad waste landscape, remain largely unacknowledged in the role they play in the circular waste economy, subsequently creating the core concern for this treatise. Hence, the building type responsible, a waste recycling facility, that looks to identify and address the needs that these individuals require to safely carry out their pivotal role within the setting of Arlington Landfill in Port Elizabeth. Therefore, this treatise looks to uncover and bring to light a day in the life of a waste picker, through an architectural intervention seeking to become more than an object on the landscape. The treatise looks to break away from a static architectural object by applying the overall lens guided by ‘Anti-Object’ writ - ten by Kengo Kuma, therefore concerning itself with an overarching process of creating an emerging anti-object architecture, embodying the subtitles and characteristics of the waste pickers of Arlington Landfill. , Thesis (MA) -- Faculty - School of Architecture, 2020
- Full Text:
- Date Issued: 2020-04
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