The Effects of Monaural Beat Technology on Learners' Experiences of Music Performance Anxiety (MPA)
- Authors: Flanagan, Jayson Edward
- Date: 2021-10-29
- Subjects: Performance anxiety Alternative treatment , School music South Africa Makhanda , Music students South Africa Makhanda Examinations , Beats (Acoustics) Psychological aspects , Monaural Beat Technology
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/10962/188419 , vital:44752
- Description: Music performance anxiety (MPA) is related to the experience of persisting, distressful, apprehensions about and/or actual impairment of performance skills in a public context, to a degree unwarranted given the individual’s musical aptitude, training and level of preparation (Salmon 1990). This research project set out to investigate learners’ subjective experiences of the effects of monaural beat (MB) vibrational frequencies on their experiences of MPA. The research project was a qualitative study based on a phenomenological research paradigm, which fundamentally aims to explore an experience in its own terms (Smith et al. 2009). The research participants consisted of four subject music pupils at St Andrew’s College and The Diocesan School for Girls and were interviewed through in-depth, semi-structured interviews over two practical examinations. The results suggested that various factors contribute to the experience of music performance anxiety, such as the performers’ perceptions of audience reactions, as well as the context of the performance. Self-esteem and the performer’s fragile sense of self-worth and self-confidence also play an important role in influencing their music performance anxiety. However, listening to monaural beats during a performance has the ability to lower levels of music performance anxiety by eliciting the following effects: an improved sense of confidence within the listeners; a sense of calm; the monaural beats working on a passive awareness level that allows the beat to operate at a sub-conscious level; the ability to focus better on the task at hand as well as benefit the listener in non-musical contexts such as studying; general concentration or ordinary tasks such as gardening or going for a run. The research suggests that listening to monaural beats during a musical performance can benefit the performer by lowering levels of MPA. As a result, the performer will experience an improved sense of confidence, calmness and the ability to focus better on the task at hand. Monaural beats have also shown to be a useful method of dealing with MPA instead of resorting to pharmaceutical drugs or other methods of coping such as playing games for distraction. , Thesis (MMus) -- Faculty of Humanities, Music and Musicology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Flanagan, Jayson Edward
- Date: 2021-10-29
- Subjects: Performance anxiety Alternative treatment , School music South Africa Makhanda , Music students South Africa Makhanda Examinations , Beats (Acoustics) Psychological aspects , Monaural Beat Technology
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/10962/188419 , vital:44752
- Description: Music performance anxiety (MPA) is related to the experience of persisting, distressful, apprehensions about and/or actual impairment of performance skills in a public context, to a degree unwarranted given the individual’s musical aptitude, training and level of preparation (Salmon 1990). This research project set out to investigate learners’ subjective experiences of the effects of monaural beat (MB) vibrational frequencies on their experiences of MPA. The research project was a qualitative study based on a phenomenological research paradigm, which fundamentally aims to explore an experience in its own terms (Smith et al. 2009). The research participants consisted of four subject music pupils at St Andrew’s College and The Diocesan School for Girls and were interviewed through in-depth, semi-structured interviews over two practical examinations. The results suggested that various factors contribute to the experience of music performance anxiety, such as the performers’ perceptions of audience reactions, as well as the context of the performance. Self-esteem and the performer’s fragile sense of self-worth and self-confidence also play an important role in influencing their music performance anxiety. However, listening to monaural beats during a performance has the ability to lower levels of music performance anxiety by eliciting the following effects: an improved sense of confidence within the listeners; a sense of calm; the monaural beats working on a passive awareness level that allows the beat to operate at a sub-conscious level; the ability to focus better on the task at hand as well as benefit the listener in non-musical contexts such as studying; general concentration or ordinary tasks such as gardening or going for a run. The research suggests that listening to monaural beats during a musical performance can benefit the performer by lowering levels of MPA. As a result, the performer will experience an improved sense of confidence, calmness and the ability to focus better on the task at hand. Monaural beats have also shown to be a useful method of dealing with MPA instead of resorting to pharmaceutical drugs or other methods of coping such as playing games for distraction. , Thesis (MMus) -- Faculty of Humanities, Music and Musicology, 2021
- Full Text:
- Date Issued: 2021-10-29
Echogenic liposomes for ultrasound-triggered drug delivery
- Authors: Izuchukwu, Ezekiel Charles
- Date: 2021-10
- Subjects: Liposomes , Drug delivery systems , Colon (Anatomy) Cancer Treatment , Transmission electron microscopy , Fourier transform infrared spectroscopy , Liquid chromatography , Echogenic liposomes , Ultrasound-triggered drug delivery
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/10962/188997 , vital:44805
- Description: Colorectal cancer is one of common cancers worldwide. It is the third most diagnosed cancer and the second leading cause of death. The use of 5-fluorouracil (5-FU) alone or in a chemotherapy regime has been the effective treatment of colorectal cancer patients. The efficacy of 5-FU in colorectal cancer treatment is significantly limited by drug resistance, gastrointestinal, and bone marrow toxicity through high-level expression of thymidylate synthase, justifying a need to improve its therapeutic index. Liposomes are colloidal membranes comprising of one or more lipid bilayers enclosing an aqueous core. They have been used to improve the therapeutic index of many anti-cancer drugs by changing drug absorption, elongating biological half-life, reducing metabolism, and reducing toxicity to healthy tissues. Echogenic liposomes are specifically designed to respond to external triggering like ultrasound stimulation by entrapping a gas or an emulsion that can vaporize. A liposome's unique property is that it can entrap both hydrophobic and hydrophilic substances simultaneously in the lipid bilayer and the aqueous core, respectively. These stimuli-responsive liposomes can be triggered externally with ultrasound, to release the chemotherapeutic cargo only at the required site. This research aims to formulate echogenic liposomes encapsulating 5-FU for potential ultrasound triggered release (echogenic). Liposome formulations wereprepared with lipid composition of crude soybean lecithin and cholesterol by thin-filmhydration method and the drug was passively loaded in the formulation. The 5-FU loadedliposomes were evaluated by dynamic light scattering (DLS) for particle size, polydispersityindex, and zeta potential and transmission electron microscopy (TEM) for morphology.Encapsulated liposomal formulations were also evaluated using physicochemical techniquesincluding thermogravimetric analysis (TGA), differential scanning calorimetry (DSC),Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). Theencapsulation efficiency and release kinetics were studied using a validated high-performanceliquid chromatography (HPLC) method. Echogenic properties were explored by entrapping abiocompatible gas (argon) at the same time as the drug (5-FU) using a pressure/freezemethodology. The liposomal formulations were typically spherical with a size of about 150 nmand encapsulation efficiency of 62%. Low-frequency ultrasound (20 kHz) was used to triggerthe drug release from the complete formulation at 10%, 15%, and 20% amplitude and exposuretime of 5 min and 10 min. The rate of drug release from the nano-carrier was a function of theultrasound amplitude and exposure time and reached a maximum of 65% release under theconditions investigated. The cumulative release was investigated, with and without theapplication of ultrasound. It was demonstrated that the application of ultrasound resulted in complete release (99%) after 12 h while this dropped to 70% without ultrasound. These results are encouraging for optimizing ultrasound parameters for triggered and controlled release of the 5-FU, for conditions such as the management of cancer where low-power ultrasound can be applied. , Thesis (MSc) -- Faculty of Science, Chemistry, 2021
- Full Text:
- Date Issued: 2021-10
- Authors: Izuchukwu, Ezekiel Charles
- Date: 2021-10
- Subjects: Liposomes , Drug delivery systems , Colon (Anatomy) Cancer Treatment , Transmission electron microscopy , Fourier transform infrared spectroscopy , Liquid chromatography , Echogenic liposomes , Ultrasound-triggered drug delivery
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/10962/188997 , vital:44805
- Description: Colorectal cancer is one of common cancers worldwide. It is the third most diagnosed cancer and the second leading cause of death. The use of 5-fluorouracil (5-FU) alone or in a chemotherapy regime has been the effective treatment of colorectal cancer patients. The efficacy of 5-FU in colorectal cancer treatment is significantly limited by drug resistance, gastrointestinal, and bone marrow toxicity through high-level expression of thymidylate synthase, justifying a need to improve its therapeutic index. Liposomes are colloidal membranes comprising of one or more lipid bilayers enclosing an aqueous core. They have been used to improve the therapeutic index of many anti-cancer drugs by changing drug absorption, elongating biological half-life, reducing metabolism, and reducing toxicity to healthy tissues. Echogenic liposomes are specifically designed to respond to external triggering like ultrasound stimulation by entrapping a gas or an emulsion that can vaporize. A liposome's unique property is that it can entrap both hydrophobic and hydrophilic substances simultaneously in the lipid bilayer and the aqueous core, respectively. These stimuli-responsive liposomes can be triggered externally with ultrasound, to release the chemotherapeutic cargo only at the required site. This research aims to formulate echogenic liposomes encapsulating 5-FU for potential ultrasound triggered release (echogenic). Liposome formulations wereprepared with lipid composition of crude soybean lecithin and cholesterol by thin-filmhydration method and the drug was passively loaded in the formulation. The 5-FU loadedliposomes were evaluated by dynamic light scattering (DLS) for particle size, polydispersityindex, and zeta potential and transmission electron microscopy (TEM) for morphology.Encapsulated liposomal formulations were also evaluated using physicochemical techniquesincluding thermogravimetric analysis (TGA), differential scanning calorimetry (DSC),Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). Theencapsulation efficiency and release kinetics were studied using a validated high-performanceliquid chromatography (HPLC) method. Echogenic properties were explored by entrapping abiocompatible gas (argon) at the same time as the drug (5-FU) using a pressure/freezemethodology. The liposomal formulations were typically spherical with a size of about 150 nmand encapsulation efficiency of 62%. Low-frequency ultrasound (20 kHz) was used to triggerthe drug release from the complete formulation at 10%, 15%, and 20% amplitude and exposuretime of 5 min and 10 min. The rate of drug release from the nano-carrier was a function of theultrasound amplitude and exposure time and reached a maximum of 65% release under theconditions investigated. The cumulative release was investigated, with and without theapplication of ultrasound. It was demonstrated that the application of ultrasound resulted in complete release (99%) after 12 h while this dropped to 70% without ultrasound. These results are encouraging for optimizing ultrasound parameters for triggered and controlled release of the 5-FU, for conditions such as the management of cancer where low-power ultrasound can be applied. , Thesis (MSc) -- Faculty of Science, Chemistry, 2021
- Full Text:
- Date Issued: 2021-10
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