From more sustainable isocyanide-based multicomponent reactions to spiro-heterocyclic compound syntheses
- Authors: Salami, Sodeeq Aderotimi
- Date: 2023-10-13
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/432229 , vital:72853 , DOI 10.21504/10962/432229
- Description: The global pharmaceutical industry has undergone profound transformations in the past two decades in the search for new drugs. For this reason, most pharmaceutical companies made significant investments not only in the development of new drugs but new methodologies. Modern drug development is confronted with the challenge of developing chemical reactions that are highly capable of providing most of the elements of structural complexity and diversity with the fewest possible synthetic steps for the specific target with the most intriguing properties. The discovery of more sustainable, environmentally friendly reactions capable of forming multiple bonds in a single step has been a challenge in organic synthesis over the years. Many organic chemists have recently started focusing on creative ways of reducing environmental pollution. The use of hazardous solvents has been reduced or eliminated in research to limit harm to both people and the environment. The pursuit of this goal has drawn many organic chemists to the study of various sustainable synthetic techniques including catalysis, aqueous organic reactions and mechanochemistry. The scope of this thesis was to apply sustainable techniques to design multicomponent synthetic protocols for the Passerini reaction and further apply these new protocols to construct spiro-heterocyclic compounds, all based on green chemistry principles. There is a need to develop rapid, efficient, and versatile strategies for the synthesis of bioactive molecules via multicomponent reactions. This project tried to avoid some of the pitfalls of traditional approaches, such as toxicity, low yield, long reaction times, harsh conditions, experimental complexity, and limited functionalization scope. This was achieved by focussing on the use of isonitriles and isothiocyanates as key reactive intermediates, and making extensive use of aqueous reaction conditions, mechanochemistry and microwave activation. , Thesis (PhD) -- Faculty of Science, Chemistry, 2023
- Full Text:
- Date Issued: 2023-10-13
- Authors: Salami, Sodeeq Aderotimi
- Date: 2023-10-13
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/432229 , vital:72853 , DOI 10.21504/10962/432229
- Description: The global pharmaceutical industry has undergone profound transformations in the past two decades in the search for new drugs. For this reason, most pharmaceutical companies made significant investments not only in the development of new drugs but new methodologies. Modern drug development is confronted with the challenge of developing chemical reactions that are highly capable of providing most of the elements of structural complexity and diversity with the fewest possible synthetic steps for the specific target with the most intriguing properties. The discovery of more sustainable, environmentally friendly reactions capable of forming multiple bonds in a single step has been a challenge in organic synthesis over the years. Many organic chemists have recently started focusing on creative ways of reducing environmental pollution. The use of hazardous solvents has been reduced or eliminated in research to limit harm to both people and the environment. The pursuit of this goal has drawn many organic chemists to the study of various sustainable synthetic techniques including catalysis, aqueous organic reactions and mechanochemistry. The scope of this thesis was to apply sustainable techniques to design multicomponent synthetic protocols for the Passerini reaction and further apply these new protocols to construct spiro-heterocyclic compounds, all based on green chemistry principles. There is a need to develop rapid, efficient, and versatile strategies for the synthesis of bioactive molecules via multicomponent reactions. This project tried to avoid some of the pitfalls of traditional approaches, such as toxicity, low yield, long reaction times, harsh conditions, experimental complexity, and limited functionalization scope. This was achieved by focussing on the use of isonitriles and isothiocyanates as key reactive intermediates, and making extensive use of aqueous reaction conditions, mechanochemistry and microwave activation. , Thesis (PhD) -- Faculty of Science, Chemistry, 2023
- Full Text:
- Date Issued: 2023-10-13
Phytoplankton communities provide insight into ecosystem functioning of the Agulhas Current system
- Authors: Gibb, Ross-Lynne Alida
- Date: 2023-03-31
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/422646 , vital:71965
- Description: Access restricted. Embargoed until 2025. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2023
- Full Text:
- Date Issued: 2023-03-31
- Authors: Gibb, Ross-Lynne Alida
- Date: 2023-03-31
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/422646 , vital:71965
- Description: Access restricted. Embargoed until 2025. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2023
- Full Text:
- Date Issued: 2023-03-31
Saul Msane: friend or foe of the people? The life of the late nineteenth to early twentieth centuries South African politician and journalist
- Authors: Mokoatsi, Thapelo
- Date: 2023-03-30
- Subjects: Saul Msane , Elite (Social sciences) , African National Congress , Politicians South Africa Biography , Political dispute , Abantu-Batho , Enemy of the people
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/409799 , vital:70631 , DOI 10.21504/10962/409802
- Description: Saul Msane was a prominent founding member of the ANC and an active journalist and editor of the ANC newspaper Abantu-Batho. His career generated controversy. Towards the end of his life, he had a feud with his colleagues in the African National Congress (henceforth Congress) that led to him being labelled isitha sabantu, “the enemy of the people” for his refusal to support the Shilling strike of 1918, an accusation which was retracted a year after his death in 1919. The label of isitha sabantu levelled against Msane, had the effect of ending his political prominence in the Transvaal, forcing him to relocate to kwaNongoma where he died shortly thereafter. Msane’s years in the Congress amounted to about seven years, between 1912, the founding of the Congress, and the demise of his career in 1919. Msane’s seven years in Congress were characterised by controversies, clashes, and conflicts owing to his perceived elitism. In Congress historiography Msane is an obscure and elusive figure, he lives here and there in a footnote, as a supporting statement or a mentioned in mere passing. His marginalisation reveals some of the gaps within the history of Congress and invites us to write about those who did not emerge from the history of Congress necessarily as heroes. This thesis sets out to write a biography of Msane and document his political career beyond that one moment in which he came to be “isitha sabantu”. While Msane’s Congress career was comparably short and filled with tensions, an archive of his life exists. This study is an exploration of that archive to reconstruct the biography of a once prominent leader who dies in political exile from the Congress movement. This thesis sets out to do two key things in relation to reconstructing Msane’s life: Firstly, it reconstructs the longer biography of Msane’s political life by drawing on the existing archives, and thus filling in the South African historical record in that regard. Secondly, at the broader conceptual and historiographical level, it argues that the controversies surrounding Msane’s persona and character illustrate that conceptions of elitism and the nature of being ‘elite’ were key to the politics of Congress at the time. , U-Saul Msane wayengomunye wabasunguli beqembu lika-African National Congress (uKhongolose) futhi eyIntatheli nomhleli wephephandaba i-Abantu-Batho. Umsebenzi ayewenza waba nezingqinamba eziningi ngokwezepolitiki. Ngasekugcineni kwempilo yakhe waba nokungazwani nabaholi ayesebenza nabo kuKhongolose okwadala ukuba abizwe ngesitha sabantu ngenxa yokuba engavumelananga nesiteleka sango-1918 lapho abasebenzi babelwela ukukhushulelwa amaholo. Leligama lokubizwa ngesitha sabantu lahoxiswa ngo 1919 sekudlule unyaka engasekho emhlabeni. Lokubizwa ngesitha sabantu kwalilimaza igama lakhe kwezepolitiki e-Transvaal waze wathutha wayohlala kwaNongoma nokuyilapho ashonela khona. Iminyaka uMsane ayisebenzele uKhongolose yaba isikhombisa, kusukela ekusungulweni kwayo ngo 1912 kuze kufike ekulimaleni komsebenzi wakhe wezepolitiki ngo 1919. Kuleminyaka eyisikhombisa umsebenzi wakhe kuKhongolose wawubhekene nokugxekwa okukhulu nokubukeka njengomuntu onokuzenza ngcono kunabanye abantu. Emlandweni kaKhongolose uMsane akavezwa ngendlela emfanele, kukhulunywa ngaye kudlulwa nje. Lokunganakwa kukaMsane emlandweni kaKhongolose kusiphoqa ukuba sibhale ngabaholi abangaqakanjiswa. Lolucwaningo luveza umlando kaMsane ngokujulile ngaphezu kwangalesikhathi abizwa khona ngesitha sabantu. Noma umsebenzi kaMsane kuKhongolose wabamfushane kunabanye futhi ugcwele izinto kodwa noko ingobo yawo ikhona. Lolucwaningo lucubungula lengobo ukuhlaziya nokubhala kabusha umlando wengqalabutho eyagcina ishonela ngaphandle kombutho kaKhongolose. Loluphando lifisa ukwenza izinto ezimbili: Okokuqala, ibhala kabusha umlando omude wezepolitiki kaMsane kusetshenziswa ulwazi olukhona. Loku kuzosiza ukunothisa umlando wezepolitiki wezwe laseNingizimu Afrika. Okwesibili, ezingeni lobunzululwazi, lolucwaningo luveza ukuthi izinkinga uMsane ahlangabezana nazo zazisukele endleleni okwakubukwa ngayo indaba yokucwasana ngazinga empilo abantu, kwakuyinto ejulile kuKhongolose ukubukeka kwabanye sengathi bazenza ngcono. , Thesis (PhD) -- Faculty of Humanities, History, 2023
- Full Text:
- Date Issued: 2023-03-30
- Authors: Mokoatsi, Thapelo
- Date: 2023-03-30
- Subjects: Saul Msane , Elite (Social sciences) , African National Congress , Politicians South Africa Biography , Political dispute , Abantu-Batho , Enemy of the people
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/409799 , vital:70631 , DOI 10.21504/10962/409802
- Description: Saul Msane was a prominent founding member of the ANC and an active journalist and editor of the ANC newspaper Abantu-Batho. His career generated controversy. Towards the end of his life, he had a feud with his colleagues in the African National Congress (henceforth Congress) that led to him being labelled isitha sabantu, “the enemy of the people” for his refusal to support the Shilling strike of 1918, an accusation which was retracted a year after his death in 1919. The label of isitha sabantu levelled against Msane, had the effect of ending his political prominence in the Transvaal, forcing him to relocate to kwaNongoma where he died shortly thereafter. Msane’s years in the Congress amounted to about seven years, between 1912, the founding of the Congress, and the demise of his career in 1919. Msane’s seven years in Congress were characterised by controversies, clashes, and conflicts owing to his perceived elitism. In Congress historiography Msane is an obscure and elusive figure, he lives here and there in a footnote, as a supporting statement or a mentioned in mere passing. His marginalisation reveals some of the gaps within the history of Congress and invites us to write about those who did not emerge from the history of Congress necessarily as heroes. This thesis sets out to write a biography of Msane and document his political career beyond that one moment in which he came to be “isitha sabantu”. While Msane’s Congress career was comparably short and filled with tensions, an archive of his life exists. This study is an exploration of that archive to reconstruct the biography of a once prominent leader who dies in political exile from the Congress movement. This thesis sets out to do two key things in relation to reconstructing Msane’s life: Firstly, it reconstructs the longer biography of Msane’s political life by drawing on the existing archives, and thus filling in the South African historical record in that regard. Secondly, at the broader conceptual and historiographical level, it argues that the controversies surrounding Msane’s persona and character illustrate that conceptions of elitism and the nature of being ‘elite’ were key to the politics of Congress at the time. , U-Saul Msane wayengomunye wabasunguli beqembu lika-African National Congress (uKhongolose) futhi eyIntatheli nomhleli wephephandaba i-Abantu-Batho. Umsebenzi ayewenza waba nezingqinamba eziningi ngokwezepolitiki. Ngasekugcineni kwempilo yakhe waba nokungazwani nabaholi ayesebenza nabo kuKhongolose okwadala ukuba abizwe ngesitha sabantu ngenxa yokuba engavumelananga nesiteleka sango-1918 lapho abasebenzi babelwela ukukhushulelwa amaholo. Leligama lokubizwa ngesitha sabantu lahoxiswa ngo 1919 sekudlule unyaka engasekho emhlabeni. Lokubizwa ngesitha sabantu kwalilimaza igama lakhe kwezepolitiki e-Transvaal waze wathutha wayohlala kwaNongoma nokuyilapho ashonela khona. Iminyaka uMsane ayisebenzele uKhongolose yaba isikhombisa, kusukela ekusungulweni kwayo ngo 1912 kuze kufike ekulimaleni komsebenzi wakhe wezepolitiki ngo 1919. Kuleminyaka eyisikhombisa umsebenzi wakhe kuKhongolose wawubhekene nokugxekwa okukhulu nokubukeka njengomuntu onokuzenza ngcono kunabanye abantu. Emlandweni kaKhongolose uMsane akavezwa ngendlela emfanele, kukhulunywa ngaye kudlulwa nje. Lokunganakwa kukaMsane emlandweni kaKhongolose kusiphoqa ukuba sibhale ngabaholi abangaqakanjiswa. Lolucwaningo luveza umlando kaMsane ngokujulile ngaphezu kwangalesikhathi abizwa khona ngesitha sabantu. Noma umsebenzi kaMsane kuKhongolose wabamfushane kunabanye futhi ugcwele izinto kodwa noko ingobo yawo ikhona. Lolucwaningo lucubungula lengobo ukuhlaziya nokubhala kabusha umlando wengqalabutho eyagcina ishonela ngaphandle kombutho kaKhongolose. Loluphando lifisa ukwenza izinto ezimbili: Okokuqala, ibhala kabusha umlando omude wezepolitiki kaMsane kusetshenziswa ulwazi olukhona. Loku kuzosiza ukunothisa umlando wezepolitiki wezwe laseNingizimu Afrika. Okwesibili, ezingeni lobunzululwazi, lolucwaningo luveza ukuthi izinkinga uMsane ahlangabezana nazo zazisukele endleleni okwakubukwa ngayo indaba yokucwasana ngazinga empilo abantu, kwakuyinto ejulile kuKhongolose ukubukeka kwabanye sengathi bazenza ngcono. , Thesis (PhD) -- Faculty of Humanities, History, 2023
- Full Text:
- Date Issued: 2023-03-30
Bioinformatics tool and web server development focusing on structural bioinformatics applications
- Authors: Nabatanzi, Margaret
- Date: 2022-10-14
- Subjects: Structural bioinformatics , Proteins Structure , Protein structure prediction , Proteins Conformation , Protein complex
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/365700 , vital:65777 , DOI https://doi.org/10.21504/10962/365700
- Description: This thesis is divided into two main sections: Part 1 describes the design, and evaluation of the accuracy of a new web server – PRotein Interactive MOdeling (PRIMO-Complexes) for modeling protein complexes and biological assemblies. The second part describes the development of bioinformatics tools to predict HIV-1 drug resistance and support bioinformatics research and education. Recent technological advances have resulted in a tremendous increase in the number of sequences and protein structures deposited in the Universal Protein Resource Knowledgebase (UniProtKB) and the Protein Data Bank (PDB). However, the number of sequences has increased at a higher rate compared with the experimentally solved multimeric protein structures. This is partly due to advances in high-throughput sequencing technology. To fill this protein sequence-structure gap, computational approaches have been developed to predict protein structures from available sequences. Computational approaches include template-based and ab initio modeling with the former being the most reliable. Template-based modeling process can be achieved using either standalone software or automated modeling web servers. However, using standalone software requires familiarity with command-line interfaces as well as utilising other intermediate programs which could be daunting to novice users. To alleviate some of these problems, the modeling process has been automated, however, it still has numerous challenges. To date, only a few web servers that support multimeric protein modeling have been developed and even these provide little, if any user involvement in the process. To address some of these issues, a new web server – PRIMO-Complexes – was developed to model protein complexes and biological assemblies. The existing PRIMO web server could only model monomeric proteins. Part 1 of this thesis provides a detailed account of the development and evaluation of PRIMO-Complexes. The rationale for developing this new web server was based on the understanding that most proteins function as protein multimers and often the ligand-binding sites, and enzyme active sites are located at the protein-protein interfaces. It, therefore, necessitated developing capabilities for modeling multimeric proteins. PRIMO-Complexes web server was developed using the Waterfall system development life cycle model, is based on the Django web framework and makes use of high-performance computing resources to execute jobs. The accuracy of the algorithms embedded in PRIMO- Complexes was evaluated and the results were promising. Additionally, PRIMO-Complexes performs comparatively well in relation to other web servers that offer multimeric protein modeling. Another unique feature of PRIMO-Complexes is its interactivity. The webserver was developed with capabilities for allowing users to model multimeric proteins with an appreciable degree of control over the process. In the second part of the thesis several other bioinformatics tools are described, for example, a webserver for predicting HIV-1 drug resistance, the RUBi protein model repository, and a bioinformatics web portal for education and research resources. RUBi protein model repository stores verified theoretical models built using various modeling approaches. This enables users to easily access models to reproduce and/or further the research. This is described in chapter 5. Chapter 6 describes the design and development of the Human Immunodeficiency type 1 Resistance Predictor (HIV-1 ResPredictor), a web application that employs artificial neural networks (ANN) to predict drug resistance in patients infected with HIV-1 subtype B. The ANNs and subtype classifiers performed well making this web application potentially useful to both clinicians and researchers in this era of personalised medicine. Finally, chapter 7 describes a bioinformatics education web portal that equips students with information on how to use bioinformatics online resources. Being aware of these resources is not enough without a deeper understanding and guidance on how to apply bioinformatics methods to solve practical problems. This web portal was aimed at familiarising students with the basic terminology and approaches in structural bioinformatics. Students will potentially gain skills to conduct real-life bioinformatics research to obtain biological insights. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2022
- Full Text:
- Date Issued: 2022-10-14
- Authors: Nabatanzi, Margaret
- Date: 2022-10-14
- Subjects: Structural bioinformatics , Proteins Structure , Protein structure prediction , Proteins Conformation , Protein complex
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/365700 , vital:65777 , DOI https://doi.org/10.21504/10962/365700
- Description: This thesis is divided into two main sections: Part 1 describes the design, and evaluation of the accuracy of a new web server – PRotein Interactive MOdeling (PRIMO-Complexes) for modeling protein complexes and biological assemblies. The second part describes the development of bioinformatics tools to predict HIV-1 drug resistance and support bioinformatics research and education. Recent technological advances have resulted in a tremendous increase in the number of sequences and protein structures deposited in the Universal Protein Resource Knowledgebase (UniProtKB) and the Protein Data Bank (PDB). However, the number of sequences has increased at a higher rate compared with the experimentally solved multimeric protein structures. This is partly due to advances in high-throughput sequencing technology. To fill this protein sequence-structure gap, computational approaches have been developed to predict protein structures from available sequences. Computational approaches include template-based and ab initio modeling with the former being the most reliable. Template-based modeling process can be achieved using either standalone software or automated modeling web servers. However, using standalone software requires familiarity with command-line interfaces as well as utilising other intermediate programs which could be daunting to novice users. To alleviate some of these problems, the modeling process has been automated, however, it still has numerous challenges. To date, only a few web servers that support multimeric protein modeling have been developed and even these provide little, if any user involvement in the process. To address some of these issues, a new web server – PRIMO-Complexes – was developed to model protein complexes and biological assemblies. The existing PRIMO web server could only model monomeric proteins. Part 1 of this thesis provides a detailed account of the development and evaluation of PRIMO-Complexes. The rationale for developing this new web server was based on the understanding that most proteins function as protein multimers and often the ligand-binding sites, and enzyme active sites are located at the protein-protein interfaces. It, therefore, necessitated developing capabilities for modeling multimeric proteins. PRIMO-Complexes web server was developed using the Waterfall system development life cycle model, is based on the Django web framework and makes use of high-performance computing resources to execute jobs. The accuracy of the algorithms embedded in PRIMO- Complexes was evaluated and the results were promising. Additionally, PRIMO-Complexes performs comparatively well in relation to other web servers that offer multimeric protein modeling. Another unique feature of PRIMO-Complexes is its interactivity. The webserver was developed with capabilities for allowing users to model multimeric proteins with an appreciable degree of control over the process. In the second part of the thesis several other bioinformatics tools are described, for example, a webserver for predicting HIV-1 drug resistance, the RUBi protein model repository, and a bioinformatics web portal for education and research resources. RUBi protein model repository stores verified theoretical models built using various modeling approaches. This enables users to easily access models to reproduce and/or further the research. This is described in chapter 5. Chapter 6 describes the design and development of the Human Immunodeficiency type 1 Resistance Predictor (HIV-1 ResPredictor), a web application that employs artificial neural networks (ANN) to predict drug resistance in patients infected with HIV-1 subtype B. The ANNs and subtype classifiers performed well making this web application potentially useful to both clinicians and researchers in this era of personalised medicine. Finally, chapter 7 describes a bioinformatics education web portal that equips students with information on how to use bioinformatics online resources. Being aware of these resources is not enough without a deeper understanding and guidance on how to apply bioinformatics methods to solve practical problems. This web portal was aimed at familiarising students with the basic terminology and approaches in structural bioinformatics. Students will potentially gain skills to conduct real-life bioinformatics research to obtain biological insights. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2022
- Full Text:
- Date Issued: 2022-10-14
Identification and characterisation of microbial communities and their metabolic potential in meltwater ponds, Western Dronning Mau Land, Antarctica
- Authors: Van Aswegen, Sunet
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/365723 , vital:65779
- Description: Thesis embargoed. Expected release date early 2024. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2022
- Full Text:
- Date Issued: 2022-10-14
- Authors: Van Aswegen, Sunet
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/365723 , vital:65779
- Description: Thesis embargoed. Expected release date early 2024. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2022
- Full Text:
- Date Issued: 2022-10-14
A Critical Assessment of the Legal and Policy Frameworks for Combating Child Trafficking in the Southern African Development Community
- Muvhevhi, Roseline Rumbidzai https://orcid.org/0009-0006-1024-5548
- Authors: Muvhevhi, Roseline Rumbidzai https://orcid.org/0009-0006-1024-5548
- Date: 2022-09
- Subjects: Child trafficking -- Law and legislation -- Africa, Southern , Child welfare -- Africa, Southern
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/26728 , vital:65969
- Description: Child trafficking is a longstanding problem which affects victims and communities in various ways and therefore requires stern action both at the global and regional level. In the Southern African Development Community (SADC) region, the crime is closely connected to the existing socio-economic challenges such as poverty; underdevelopment; lack of equal economic opportunities; HIV/AIDS; and human rights violations. As a result, SADC States are fertile sources, transit zones and destinations for child trafficking. It is internationally recognised that it is States such as those in the SADC region that require a comprehensive approach to prevent and prosecute the crime while simultaneously ensuring victim protection. To this effect, the Protocol to Prevent, Suppress and Punish Trafficking in Persons Especially Women and Children is the primary instrument that seeks to provide such a comprehensive approach to child trafficking. Therefore, the current regional and national responses to child trafficking in most SADC States, are influenced by this Protocol. Despite these legislative and policy efforts to combat the crime, statistics show that in recent years child trafficking has been rapidly increasing in SADC. Thus, this research seeks to investigate why child trafficking remains prevalent in the region despite a plethora of measures against the crime. The research, therefore, assesses the effectiveness of the legal and policy measures taken by the SADC States to combat child trafficking using a qualitative approach involving analysis and interpretation of relevant legislation and policies. The primary focus is on the Trafficking Protocol as the main child trafficking instrument at the international level. The role of non-child trafficking instruments in the absence of a community instrument against the crime in SADC is also analysed. This research observes that the increasing child trafficking problem in the region is not mainly because of a lack of adequate legislation or policies but the lack of effective implementation of measures. Without a regional comprehensive and coordinated implementation approach, these measures remain weak and inadequate to fully combat child trafficking in the region. To this end, numerous legislative, policy, institutional and operational reform mechanisms to strengthen the subsisting measures against child trafficking in the region and areas for further research are recommended. , Thesis (LLD) -- Faculty of Law, 2022
- Full Text:
- Date Issued: 2022-09
- Authors: Muvhevhi, Roseline Rumbidzai https://orcid.org/0009-0006-1024-5548
- Date: 2022-09
- Subjects: Child trafficking -- Law and legislation -- Africa, Southern , Child welfare -- Africa, Southern
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/26728 , vital:65969
- Description: Child trafficking is a longstanding problem which affects victims and communities in various ways and therefore requires stern action both at the global and regional level. In the Southern African Development Community (SADC) region, the crime is closely connected to the existing socio-economic challenges such as poverty; underdevelopment; lack of equal economic opportunities; HIV/AIDS; and human rights violations. As a result, SADC States are fertile sources, transit zones and destinations for child trafficking. It is internationally recognised that it is States such as those in the SADC region that require a comprehensive approach to prevent and prosecute the crime while simultaneously ensuring victim protection. To this effect, the Protocol to Prevent, Suppress and Punish Trafficking in Persons Especially Women and Children is the primary instrument that seeks to provide such a comprehensive approach to child trafficking. Therefore, the current regional and national responses to child trafficking in most SADC States, are influenced by this Protocol. Despite these legislative and policy efforts to combat the crime, statistics show that in recent years child trafficking has been rapidly increasing in SADC. Thus, this research seeks to investigate why child trafficking remains prevalent in the region despite a plethora of measures against the crime. The research, therefore, assesses the effectiveness of the legal and policy measures taken by the SADC States to combat child trafficking using a qualitative approach involving analysis and interpretation of relevant legislation and policies. The primary focus is on the Trafficking Protocol as the main child trafficking instrument at the international level. The role of non-child trafficking instruments in the absence of a community instrument against the crime in SADC is also analysed. This research observes that the increasing child trafficking problem in the region is not mainly because of a lack of adequate legislation or policies but the lack of effective implementation of measures. Without a regional comprehensive and coordinated implementation approach, these measures remain weak and inadequate to fully combat child trafficking in the region. To this end, numerous legislative, policy, institutional and operational reform mechanisms to strengthen the subsisting measures against child trafficking in the region and areas for further research are recommended. , Thesis (LLD) -- Faculty of Law, 2022
- Full Text:
- Date Issued: 2022-09
Clinical governance implementation challenges in the Department of Health, Mpumalanga, South Africa
- Maduna, Patrick Hawkins https://orcid.org/0000-0002-4926-1661
- Authors: Maduna, Patrick Hawkins https://orcid.org/0000-0002-4926-1661
- Date: 2022-09
- Subjects: Clinical competence , Health services administration
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/27275 , vital:66532
- Description: Clinical governance (CG) is the system through which health authorities are accountable for continuously improving the quality of their services and safeguarding high standards of care by creating an environment in which clinical excellence flourishes. South Africa is one of the countries where CG has not been successfully implemented. This study sought to explore the CG implementation challenges in the Mpumalanga province, South Africa. The study objectives included the seven pillars of CG. The study was a qualitative and exploratory, using purposive sampling technique to select study participants. A total of twenty-two (22) individuals were selected for the study. Semi-structured interviews were used for data collection. Each interview was transcribed verbatim by the researcher. Confidentiality was ensured through the coding of interviewee names. The content analysis technique was used for data analysis, using the study objectives as themes. The study found general lack of understanding of the concept of CG, poor performance of clinical audits, sub-standard clinical performance and effectiveness, poor clinical risk management, poor patient and public involvement in patient care, lack of evidence-based practice and research, inadequate training and development of healthcare workers, and sub-standard health information management across the department. The researcher recommends that the CG policy be prioritised by the Mpumalanga DOH, that systems be put in place to facilitate policy implementation, and that the departmental staff establishments at all levels, prioritise healthcare professionals in key leadership positions. In conclusion, there are numerous challenges that confront the Mpumalanga Department of Health regarding the implementation of clinical governance, requiring urgent attention. , Thesis (PhD) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-09
- Authors: Maduna, Patrick Hawkins https://orcid.org/0000-0002-4926-1661
- Date: 2022-09
- Subjects: Clinical competence , Health services administration
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/27275 , vital:66532
- Description: Clinical governance (CG) is the system through which health authorities are accountable for continuously improving the quality of their services and safeguarding high standards of care by creating an environment in which clinical excellence flourishes. South Africa is one of the countries where CG has not been successfully implemented. This study sought to explore the CG implementation challenges in the Mpumalanga province, South Africa. The study objectives included the seven pillars of CG. The study was a qualitative and exploratory, using purposive sampling technique to select study participants. A total of twenty-two (22) individuals were selected for the study. Semi-structured interviews were used for data collection. Each interview was transcribed verbatim by the researcher. Confidentiality was ensured through the coding of interviewee names. The content analysis technique was used for data analysis, using the study objectives as themes. The study found general lack of understanding of the concept of CG, poor performance of clinical audits, sub-standard clinical performance and effectiveness, poor clinical risk management, poor patient and public involvement in patient care, lack of evidence-based practice and research, inadequate training and development of healthcare workers, and sub-standard health information management across the department. The researcher recommends that the CG policy be prioritised by the Mpumalanga DOH, that systems be put in place to facilitate policy implementation, and that the departmental staff establishments at all levels, prioritise healthcare professionals in key leadership positions. In conclusion, there are numerous challenges that confront the Mpumalanga Department of Health regarding the implementation of clinical governance, requiring urgent attention. , Thesis (PhD) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-09
Clinical governance implementation challenges in the Department of Health, Mpumalanga, South Africa
- Maduna, Patrick Hawkins https://orcid.org/0000-0002-4926-1661
- Authors: Maduna, Patrick Hawkins https://orcid.org/0000-0002-4926-1661
- Date: 2022-09
- Subjects: Clinical competence , Evidence-based medicine , Health services administration
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/23600 , vital:58194
- Description: Clinical governance (CG) is the system through which health authorities are accountable for continuously improving the quality of their services and safeguarding high standards of care by creating an environment in which clinical excellence flourishes. South Africa is one of the countries where CG has not been successfully implemented. This study sought to explore the CG implementation challenges in the Mpumalanga province, South Africa. The study objectives included the seven pillars of CG. The study was a qualitative and exploratory, using purposive sampling technique to select study participants. A total of twenty-two (22) individuals were selected for the study. Semi-structured interviews were used for data collection. Each interview was transcribed verbatim by the researcher. Confidentiality was ensured through the coding of interviewee names. The content analysis technique was used for data analysis, using the study objectives as themes. The study found general lack of understanding of the concept of CG, poor performance of clinical audits, sub-standard clinical performance and effectiveness, poor clinical risk management, poor patient and public involvement in patient care, lack of evidence-based practice and research, inadequate training and development of healthcare workers, and sub-standard health information management across the department. The researcher recommends that the CG policy be prioritised by the Mpumalanga DOH, that systems be put in place to facilitate policy implementation, and that the departmental staff establishments at all levels, prioritise healthcare professionals in key leadership positions. In conclusion, there are numerous challenges that confront the Mpumalanga Department of Health regarding the implementation of clinical governance, requiring urgent attention. , Thesis (PhD) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-09
- Authors: Maduna, Patrick Hawkins https://orcid.org/0000-0002-4926-1661
- Date: 2022-09
- Subjects: Clinical competence , Evidence-based medicine , Health services administration
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/23600 , vital:58194
- Description: Clinical governance (CG) is the system through which health authorities are accountable for continuously improving the quality of their services and safeguarding high standards of care by creating an environment in which clinical excellence flourishes. South Africa is one of the countries where CG has not been successfully implemented. This study sought to explore the CG implementation challenges in the Mpumalanga province, South Africa. The study objectives included the seven pillars of CG. The study was a qualitative and exploratory, using purposive sampling technique to select study participants. A total of twenty-two (22) individuals were selected for the study. Semi-structured interviews were used for data collection. Each interview was transcribed verbatim by the researcher. Confidentiality was ensured through the coding of interviewee names. The content analysis technique was used for data analysis, using the study objectives as themes. The study found general lack of understanding of the concept of CG, poor performance of clinical audits, sub-standard clinical performance and effectiveness, poor clinical risk management, poor patient and public involvement in patient care, lack of evidence-based practice and research, inadequate training and development of healthcare workers, and sub-standard health information management across the department. The researcher recommends that the CG policy be prioritised by the Mpumalanga DOH, that systems be put in place to facilitate policy implementation, and that the departmental staff establishments at all levels, prioritise healthcare professionals in key leadership positions. In conclusion, there are numerous challenges that confront the Mpumalanga Department of Health regarding the implementation of clinical governance, requiring urgent attention. , Thesis (PhD) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-09
Consumerism, authenticity and African communalism
- Smook, E https://orcid.org/0000-0003-4226-6029
- Authors: Smook, E https://orcid.org/0000-0003-4226-6029
- Date: 2022-09
- Subjects: Consumption (Economics) , Authenticity (Philosophy) , Philosophy, African
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/23958 , vital:62022
- Description: Let me state, from the outset, that the issues raised below may be considered from various vantage points – Capitalism, Marxism, etc. However, this thesis is an endeavour to account for the loss of authenticity due to the most salient features of the consumer paradigm, which is the manufactured object, the production line and the proliferation of said objects. True relationships, or shall we say authentic dialogue, is based upon a difference of viewpoints – or epistemic distance – between the interlocutors. This difference of opinion, it may be argued, allows for a cognitive jostling between the subjects involved and represents, as it were, the reciprocal back and forth movement of ideas that betokens actively engaged dialogue. Crucial, then, to true, and by extension authentic, relationships is an epistemic distance steeped in variegated, heterogeneous points of view. For it is in sharing the differences in our points of view or interpretations of the world that we may start a dialogue far removed from each other and then sustain said dialogue in an attempt to reconcile our differences. The continuation of the dialogue, then, depends upon difference. Without the latter difference, the conditions of true dialogue, which is also a marker of authentic relationships, the need for sustained debate is forfeited and the dialogue ceases to serve a purpose – for the subjects involved in the intellectual jostling and exchange of ideas may already anticipate the thoughts of the other. In so anticipating the thoughts of the other, what is brought to the fore is not the ideas of the other, and by extension the other’s existence distinct from mine, but rather my own existence and thoughts. Were I and the other to share a constellation of beliefs, I am left with only that which I already believe in and so only with my own thoughts. The other’s differing opinion is crucial to their appearing to me as an element discreet and distinct from me. For if the other’s being is in essence of the same ilk as mine – and with that I mean if the other’s points of view and adopted systems of praxis mirror mine – we are like trees in a forest. The existence of collective nouns attests to this latter remark; we are prone to see the forest, not the similar trees that constitute it. Now the question arises as to the constitution of the self; what is it that makes up the character and nature of a person and how, if at all, may subjects be said to differ epistemically? According to Sartre, the ego is a transcendent object for consciousness, meaning that it exists out there in the world just like other objects. This is the case because consciousness is essentially empty. Recall Sartre’s famous claim that existence precedes essence, which in turn means that consciousness, or the ego, is filled up inchmeal with contents outside itself. In other words, that with which we are engaged constitutes the contents of consciousness. Repeated exposure to certain objects, or phenomena, brings about the cultivation of states and qualities – these, as it were, constituting the ego in the end. Moreover, these states and qualities, as arisen from repeated exposure to like phenomena, will instil in the subject a certain proclivity for a certain manner of action under specific conditions. As such, having been presented with something disagreeable many times over, a state of repulsion might gain a foothold in my ego regarding the phenomenon in question. This in turn will dictate how I act in the presence of said phenomenon or any other phenomena that include, adumbrationally, some of the qualities of the original phenomenon. As such, then, my actions are reflections of the states that I experience in the presence of certain objects or phenomena and, it may be argued, reflexively represent the world around me as that which constitutes my ego. The facticity of the world, then, has a great bearing upon the manner in which I perceive and engage the world. However, claims Sartre, facticity is but one side of the coin. The world and its meaning are constituted by what Sartre calls brute meaning. This refers to the fact that meaning is a matter of public opinion and does not precede the phenomenon or object itself – the latter being, in essence, but a bare, pliable, monstrous mass of being-in-itself. Due to this occurrence of meaning being man made, we are in a unique position of freedom. We are, he further claims, capable of transcending these brute meanings, enabling us to avail ourselves of the objects or phenomena in question in a bespoke manner. Freedom to choose how we interact with and interpret the world is thus the ontological ground of choice. We have, on the one side, the world in its undifferentiated state – being-in-itself – and on the other the possibility to give this world a specific meaning in accordance with our intentions – being-for-itself. Freedom to choose, so construed, thus ontologically underlies the very fabric of our existence, hence the claim that we are condemned to be free. Choosing whether to continue along the path set out by our original factual condition or to transcend it and make of it something different altogether is thus not a choice at all, but the obligatory condition of the human condition. Once again, this is the case because consciousness, as per Sartre, is empty to start with and can only be filled with the contents of phenomena or objects in accordance with our intentional engagement of them. However, Sartre continues, this freedom of meaning and the fact that brute existents represent nothing more than the convergence of publicly ascribed meaning awaken in the subject a certain nausea – a nausea born of the fact that we, the people, are at every junction in a position where we have to choose the meaning of life. Determinism, thusly, does not exist and we are not only free to choose the meanings of our own lives, but are responsible for what our lives become. This realisation proves to be too much for most to stomach and leads them along a specific path of choice: over-identification with either their factual realities or with the possibility to transcend the latter. Either way, what they aim to achieve with this overidentification is the suppression of the nauseating reality that reality is nought but what we make it to be and we are thus responsible for what it becomes. Sartre calls this bad faith. Pandering to this proclivity towards bad faith, or alternatively, the propensity for overidentification with either side on the facticity/transcendence dichotomy, we find consumerism. The consumer paradigm delineates happiness as an objective ideal, attainable through the acquisition of specific markers of demonstrable happiness. At the same time, it also provides an answer to the nauseating reality that we, humans, are never fully determined beings, but find ourselves vacillating between our factual constraints and our transcendences thereof. It offers us the crystalised means of becoming this or that individual by way of populating our immediate and personal surroundings with signifiers of happiness. Considering, moreover, that a liberalist conception of human being clearly indicates that individuation of each subject is an important aspect of existence, authenticity in terms of rights emerge as a corollary of said individuation. Each individual, so construed, is given the opportunity, the right, to acquire said markers of happiness and individuation. Obtaining these, it may be argued, allows the individual two things: firstly, to quell the nausea that haunts our dualistic lives by concretising it altogether and so doing highlighting the factual side of things; and secondly, to become discreet and individuated subjects, authentic in their beings. However, the authenticity so begotten provides nought but a thin veneer of idiosyncrasy, as the markers of said authenticity are publicly available and so the same for everyone. The problem, thus, of self-individuation is resolved by providing the subject the means of over-identification with their factual realities whilst convincing them, the consumers, that the objects on offer will afford them a degree of happiness and set them apart from their fellow subjects. The unfortunate upshot of this is that subjects all avail themselves of the same set of objects in an attempt to quell the nausea that besets the individual plunged into an undifferentiated existence. We are here at the heart of the matter. Due to the proliferation of like objects throughout the life-world, a specific system of praxis is implied. So as to navigate the life-world and utilise the similar objects that populate it, consumers are driven towards shared ideologies and courses of action. Moreover, their intentions also converge, as they all seek to establish a web of objects around them that would bespeak their individuation and happiness. Where the life-world has become such a homogeneous landscape, it may be argued, in line with Sartrean thought, that the contents of consciousness would also be similar for all. And where the contents of consciousness is similar for all, we may argue that reasoning would be similar for all. It is at this point that dialogue breaks down, for there is nothing epistemically to separate interlocutors and therefore no differences of opinion to sustain true dialogue. If, as it was reasoned some pages prior, it is the case that sustained dialogue provides the predicate upon which authentic relationships are to be based, the collapse of this epistemic distance between consumers must then also lead to a collapse of authentic relationships. , Thesis (PhD) -- Faculty of Social Sciences and Humanities, 2022
- Full Text:
- Date Issued: 2022-09
- Authors: Smook, E https://orcid.org/0000-0003-4226-6029
- Date: 2022-09
- Subjects: Consumption (Economics) , Authenticity (Philosophy) , Philosophy, African
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/23958 , vital:62022
- Description: Let me state, from the outset, that the issues raised below may be considered from various vantage points – Capitalism, Marxism, etc. However, this thesis is an endeavour to account for the loss of authenticity due to the most salient features of the consumer paradigm, which is the manufactured object, the production line and the proliferation of said objects. True relationships, or shall we say authentic dialogue, is based upon a difference of viewpoints – or epistemic distance – between the interlocutors. This difference of opinion, it may be argued, allows for a cognitive jostling between the subjects involved and represents, as it were, the reciprocal back and forth movement of ideas that betokens actively engaged dialogue. Crucial, then, to true, and by extension authentic, relationships is an epistemic distance steeped in variegated, heterogeneous points of view. For it is in sharing the differences in our points of view or interpretations of the world that we may start a dialogue far removed from each other and then sustain said dialogue in an attempt to reconcile our differences. The continuation of the dialogue, then, depends upon difference. Without the latter difference, the conditions of true dialogue, which is also a marker of authentic relationships, the need for sustained debate is forfeited and the dialogue ceases to serve a purpose – for the subjects involved in the intellectual jostling and exchange of ideas may already anticipate the thoughts of the other. In so anticipating the thoughts of the other, what is brought to the fore is not the ideas of the other, and by extension the other’s existence distinct from mine, but rather my own existence and thoughts. Were I and the other to share a constellation of beliefs, I am left with only that which I already believe in and so only with my own thoughts. The other’s differing opinion is crucial to their appearing to me as an element discreet and distinct from me. For if the other’s being is in essence of the same ilk as mine – and with that I mean if the other’s points of view and adopted systems of praxis mirror mine – we are like trees in a forest. The existence of collective nouns attests to this latter remark; we are prone to see the forest, not the similar trees that constitute it. Now the question arises as to the constitution of the self; what is it that makes up the character and nature of a person and how, if at all, may subjects be said to differ epistemically? According to Sartre, the ego is a transcendent object for consciousness, meaning that it exists out there in the world just like other objects. This is the case because consciousness is essentially empty. Recall Sartre’s famous claim that existence precedes essence, which in turn means that consciousness, or the ego, is filled up inchmeal with contents outside itself. In other words, that with which we are engaged constitutes the contents of consciousness. Repeated exposure to certain objects, or phenomena, brings about the cultivation of states and qualities – these, as it were, constituting the ego in the end. Moreover, these states and qualities, as arisen from repeated exposure to like phenomena, will instil in the subject a certain proclivity for a certain manner of action under specific conditions. As such, having been presented with something disagreeable many times over, a state of repulsion might gain a foothold in my ego regarding the phenomenon in question. This in turn will dictate how I act in the presence of said phenomenon or any other phenomena that include, adumbrationally, some of the qualities of the original phenomenon. As such, then, my actions are reflections of the states that I experience in the presence of certain objects or phenomena and, it may be argued, reflexively represent the world around me as that which constitutes my ego. The facticity of the world, then, has a great bearing upon the manner in which I perceive and engage the world. However, claims Sartre, facticity is but one side of the coin. The world and its meaning are constituted by what Sartre calls brute meaning. This refers to the fact that meaning is a matter of public opinion and does not precede the phenomenon or object itself – the latter being, in essence, but a bare, pliable, monstrous mass of being-in-itself. Due to this occurrence of meaning being man made, we are in a unique position of freedom. We are, he further claims, capable of transcending these brute meanings, enabling us to avail ourselves of the objects or phenomena in question in a bespoke manner. Freedom to choose how we interact with and interpret the world is thus the ontological ground of choice. We have, on the one side, the world in its undifferentiated state – being-in-itself – and on the other the possibility to give this world a specific meaning in accordance with our intentions – being-for-itself. Freedom to choose, so construed, thus ontologically underlies the very fabric of our existence, hence the claim that we are condemned to be free. Choosing whether to continue along the path set out by our original factual condition or to transcend it and make of it something different altogether is thus not a choice at all, but the obligatory condition of the human condition. Once again, this is the case because consciousness, as per Sartre, is empty to start with and can only be filled with the contents of phenomena or objects in accordance with our intentional engagement of them. However, Sartre continues, this freedom of meaning and the fact that brute existents represent nothing more than the convergence of publicly ascribed meaning awaken in the subject a certain nausea – a nausea born of the fact that we, the people, are at every junction in a position where we have to choose the meaning of life. Determinism, thusly, does not exist and we are not only free to choose the meanings of our own lives, but are responsible for what our lives become. This realisation proves to be too much for most to stomach and leads them along a specific path of choice: over-identification with either their factual realities or with the possibility to transcend the latter. Either way, what they aim to achieve with this overidentification is the suppression of the nauseating reality that reality is nought but what we make it to be and we are thus responsible for what it becomes. Sartre calls this bad faith. Pandering to this proclivity towards bad faith, or alternatively, the propensity for overidentification with either side on the facticity/transcendence dichotomy, we find consumerism. The consumer paradigm delineates happiness as an objective ideal, attainable through the acquisition of specific markers of demonstrable happiness. At the same time, it also provides an answer to the nauseating reality that we, humans, are never fully determined beings, but find ourselves vacillating between our factual constraints and our transcendences thereof. It offers us the crystalised means of becoming this or that individual by way of populating our immediate and personal surroundings with signifiers of happiness. Considering, moreover, that a liberalist conception of human being clearly indicates that individuation of each subject is an important aspect of existence, authenticity in terms of rights emerge as a corollary of said individuation. Each individual, so construed, is given the opportunity, the right, to acquire said markers of happiness and individuation. Obtaining these, it may be argued, allows the individual two things: firstly, to quell the nausea that haunts our dualistic lives by concretising it altogether and so doing highlighting the factual side of things; and secondly, to become discreet and individuated subjects, authentic in their beings. However, the authenticity so begotten provides nought but a thin veneer of idiosyncrasy, as the markers of said authenticity are publicly available and so the same for everyone. The problem, thus, of self-individuation is resolved by providing the subject the means of over-identification with their factual realities whilst convincing them, the consumers, that the objects on offer will afford them a degree of happiness and set them apart from their fellow subjects. The unfortunate upshot of this is that subjects all avail themselves of the same set of objects in an attempt to quell the nausea that besets the individual plunged into an undifferentiated existence. We are here at the heart of the matter. Due to the proliferation of like objects throughout the life-world, a specific system of praxis is implied. So as to navigate the life-world and utilise the similar objects that populate it, consumers are driven towards shared ideologies and courses of action. Moreover, their intentions also converge, as they all seek to establish a web of objects around them that would bespeak their individuation and happiness. Where the life-world has become such a homogeneous landscape, it may be argued, in line with Sartrean thought, that the contents of consciousness would also be similar for all. And where the contents of consciousness is similar for all, we may argue that reasoning would be similar for all. It is at this point that dialogue breaks down, for there is nothing epistemically to separate interlocutors and therefore no differences of opinion to sustain true dialogue. If, as it was reasoned some pages prior, it is the case that sustained dialogue provides the predicate upon which authentic relationships are to be based, the collapse of this epistemic distance between consumers must then also lead to a collapse of authentic relationships. , Thesis (PhD) -- Faculty of Social Sciences and Humanities, 2022
- Full Text:
- Date Issued: 2022-09
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