Structural modification of RhIIItriarylcorroles for enhanced electrocatalyzed hydrogen evolution reactions
- Authors: Zhu, Weihua , Li, Lihua , Wang, Yu , Mack, John , Dingiswayo, Somila , Nyokong, Tebello , Liang, Xu
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/229933 , vital:49724 , xlink:href="https://doi.org/10.1016/j.dyepig.2021.110046"
- Description: A series of A3 type RhIIItriarylcorroles 2a-c with different meso-substituents with differing electron-donating and withdrawing properties and two A2B type RhIIItriarylcorroles 4a-b with meso-methylthiophenyls at the B position have been prepared and characterized. An analysis of structure-property relationships of 2a-c and 4a-b has been carried out by comparing the optical spectroscopy and electrochemistry of the dyes to trends predicted in DFT and TD-DFT calculations. Rational structural modification strategies that enhance the suitability of 2a-c for use as highly efficient catalysts for hydrogen evolution reactions on glassy carbon electrodes coated with 2a-c/reduced graphene oxide composites and of 4a-b in surface-modified Au electrodes are explored.
- Full Text:
- Date Issued: 2022
Symmetry effect of cobalt phthalocyanines on the aluminium corrosion inhibition in hydrochloric acid
- Authors: Nnaji, Nnaemeka , Sen, Pinar , Nyokong, Tebello
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/231323 , vital:49877 , xlink:href="https://doi.org/10.1016/j.matlet.2021.130892"
- Description: The aluminium corrosion retardation potentials of phthalocyanine-based dyes, cobalt (II) 2,9,16-tris(4-(tert-butyl)phenoxy)-23-(pyridin-4-yloxy)phthalocyanine (D1) and cobalt (II) 2,9,16,24-tetrakis(4-(tert-butyl)phenoxy)phthalocyanine (D2) in 1 M hydrochloric acid were evaluated. Results from potentiodynamic polarization measurements show that inhibition efficiency increased with inhibitor concentration at 28 °C with values of 91.9 % and 87.0 % values respectively for D1 and D2 at 10 μM.
- Full Text:
- Date Issued: 2022
Synergistic recognition and electrochemical sensing of 17β-Estradiol using ordered molecularly imprinted polymer-graphene oxide-silver nanoparticles composite films
- Authors: Regasa, Melkamu Biyana , Nyokong, Tebello
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/295829 , vital:57382 , xlink:href="https://doi.org/10.1016/j.jelechem.2022.116713"
- Description: Synthetic molecularly imprinted polymers (MIPs) based functional materials become the best alternatives to alleviate the stability and cost issues related to biological receptors commonly used in biochemical sensors. To address this demand, we report the development of a highly selective and sensitive MIPs-based electrochemical sensor for the detection of 17β-estradiol (E2). The sensor was prepared based on the MIP-graphene oxide (GO)-silver nanoparticle (AgNP) nanocomposite functional materials electrodeposited on the surface of the glassy carbon electrode (GCE). At first, AgNp formation was facilitated by using ascorbic acid to reduce and stabilize it. A very stable MIP-GO-AgNP sensing layer with multifunctional units were formed using imidazole as a functional monomer (p-type-electron acceptor), GO (n-type-electron donor), and AgNP by using the electrodeposition method. The role of GO in the system is providing additional functional units to bind the template and improve materials morphology while that of AgNPs is acting as a catalyst and charge carrier. The characterization of the sensing materials was done by using Fourier transform infrared, scanning electron microscopy, energy dispersive X-ray spectroscopy, and cyclic voltammetry. After optimization of the essential parameters, the sensor was successfully applied to detect the target analyte using the square wave voltammetric technique. The prepared sensor exhibited a wide linear range of 10 fM-250 nM with the limit of detection and limit of quantification of 3.01 fM and 10.03 fM, respectively. The high percentage recoveries, sensitivity, repeatability, and easy fabrication of the MIP-GO-AgNP materials made the proposed sensor promising for environmental monitoring applications in the future.
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- Date Issued: 2022
The effect of charge on Zn tetra morpholine porphyrin conjugated to folic acid-nitrogen doped graphene quantum dots for photodynamic therapy studies
- Authors: Magaela, N Bridged , Matshitse, Refilwe , Nyokong, Tebello
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/295840 , vital:57383 , xlink:href="https://doi.org/10.1016/j.pdpdt.2022.102898"
- Description: Zinc tetra morpholine porphyrin (complex 2), and its quaternized derivative (complex 3) were synthesized and conjugated to folic acid decorated nitrogen doped graphene quantum dots (FA-NGQDs) through π−π stacking to study their photodynamic therapy (PDT) efficacy. Photophysiochemical properties of complexes 2, 3, and their conjugates (2-FA-NGQDs, 3-FA-NGQDs) were studied. It was found that complex 3 had higher ϕΔ of 0.56 compared to complex 2 with ϕΔ of 0.24, and respective composites: 3-FA-NGQDs had higher ϕΔ compared to 2-FA-NGQDs. The PDT studies were conducted for nanoparticles (FA-NGQDs), complexes (2, 3), and respective composites (2-FA-NGQDs, and 3-FA-NGQDs) using MCF-7 breast cancer cell. Dark toxicity of all compounds was above 90% which is negligible. At a highest concentration of 40 µg/mL, 3-FA-NGQDs gave the lowest cell viability of 28% compared to all other conjugates and porphyrins alone.
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- Date Issued: 2022
The Electrocatalytic Detection of Nitrite Using Manganese Schiff Base Phthalocyanine Complexes
- Authors: Ndebele, Nobuhle , Nyokong, Tebello
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/295856 , vital:57385 , xlink:href="https://doi.org/10.1007/s12678-022-00752-4"
- Description: This work investigates the use of manganese phthalocyanines (MnPcs) in the electrochemical detection of nitrite. These are two Schiff base derivatives: tetrakis 4-(4-thio-thiophene-2-ylmethanamino) phthalocyaninato Mn(III)Cl (2) and tetrakis 4-(3-(pyrrolidine-1-yl)propan-1-amino)phthalocyaninato Mn(III)Cl (3) and one aldehyde: tetrakis(4-formylphenoxy)phthalocyaninato Mn(III)Cl (1). The MnPc complexes were adsorbed onto the glassy carbon electrode surface using the drop-dry method and used as electrocatalysts to detect nitrite. Nitrite oxidation peak potentials obtained using cyclic voltammetry ranged between 0.70 and 0.84 V. Detection limits as low as 0.16 µM and sensitivity values as high as 276 µMmM−1 were obtained through the use of chronoamperometry. The Schiff base MnPcs 2 and 3 exhibited better nitrite detection properties (in terms of limit of detection and sensitivity) than their aldehyde precursor (1).
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- Date Issued: 2022
The implications of ortho-, meta-and para-directors on the in-vitro photodynamic antimicrobial chemotherapy activity of cationic pyridyl-dihydrothiazole phthalocyanines
- Authors: Magadla, Aviwe , Openda, Yolande Ikala , Nyokong, Tebello
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/295875 , vital:57386 , xlink:href="https://doi.org/10.1016/j.pdpdt.2022.103029"
- Description: Cationic Zn phthalocyanine complexes were derived by alkylation reaction of tetra-(pyridinyloxy) phthalocyanines (Pcs) at the ortho, meta, and para positions to form Zn (II) tetrakis 3-(4-(2-pyridin-1-ium-1-yl) butyl)-2-mercapto-4,5-dihydrothiazol-3-ium phthalocyanine (2), Zn (II) tetrakis 3-(4-(3-pyridin-1-ium-1-yl) butyl)-2-mercapto-4,5-dihydrothiazol-3-ium phthalocyanine (4) and Zn (II) tetrakis 3-(4-(4-pyridin-1-ium-1-yl) butyl)-2-mercapto-4,5-dihydrothiazol-3-ium phthalocyanine (6). The photophysicochemical behaviors of the Pc complexes were assessed. The meta and para-substituted complexes gave high singlet oxygen quantum yields. The cationic Pcs demonstrated good planktonic antibacterial activity against Staphylococcus aureus and Escherichia coli with the high log reduction values of 9.29 and 8.55, respectively. The cationic complexes also showed a significant decrease in the viability of in vitro biofilms after photo-antimicrobial chemotherapy at 100 µM for both Staphylococcus aureus and Escherichia coli biofilms.
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- Date Issued: 2022
The in vitro photo-sonodynamic combinatorial therapy activity of cationic and zwitterionic phthalocyanines on MCF-7 and HeLa cancer cell lines
- Authors: Nene, Lindokuhle Cindy , Buthelezi, Khanyisile , Prinsloo, Earl , Nyokong, Tebello
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/295891 , vital:57387 , xlink:href="https://doi.org/10.1016/j.jphotochem.2022.114116"
- Description: The syntheses and characterization studies of zwitterionic 2,9,16,23-tetrakis-(N-propane sultone-morpholino) zinc(II) (4) and 2,9,16,23-tetrakis-(2,5-dimethyl-4-(N-propane sultone-morpholinomethyl))-phenoxy zinc(II) (6) phthalocyanines are reported in this work. The photophysical properties, reactive oxygen species (ROS) generation and in vitro anticancer photodynamic (PDT), sonodynamic (SDT), and photo-sonodynamic combination (PSDT) therapy activities of the Pcs were studied and compared to their cationic counterparts: (2,9,16,23-tetrakis-(N-methyl-morpholino) Zn(II)Pc, 3), (2,9,16,23-tetrakis-(2,5-dimethyl-4-(N-methylmorpholine)-phenoxy) Zn(II)Pc, 5). The cationic Pcs maintained higher anticancer activity for all treatment types and had higher ROS generation compared to the zwitterionic Pcs. Singlet oxygen and hydroxyl radicals were generated during ultrasound and combination irradiations of the Pcs. The zwitterionic Pcs also generated carbon radicals under ultrasound and combination irradiations. The ability of the Pcs to generate ROS is essential for PDT, SDT and PSDT, thus making these Pcs potential anticancer probes for these treatment types. Furthermore, the Pcs demonstrated the ability to bind to bovine serum albumin protein.
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- Date Issued: 2022
The photocatalytic properties of zinc phthalocyanines supported on hematite nanofibers for use against methyl orange and Staphylococcus aureus
- Authors: Mapukata, Sivuyisiwe , Britton, Jonathan , Nwahara, Nnamdi , Nyokong, Tebello
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/230184 , vital:49751 , xlink:href="https://doi.org/10.1016/j.jphotochem.2021.113637"
- Description: Heterogeneous photocatalysis is a promising approach for environmental remediation from contaminants including microorganisms and organic pollutants. In this work, hematite nanofibers are fabricated and modified with a novel monosubstituted Pc (4) as well as an asymmetrical tetrasubstituted Pc (5) with the aim of creating hybrid photocatalysts. The photocatalytic activities of the unmodified and phthalocyanine modified hematite nanofibers were compared based on their efficiencies in the photoinactivation of S. aureus and photooxidation of methyl orange. For both applications, the hybrid nanofibers were found to be more efficient photocatalysts than the unmodified hematite nanofibers. Comparison of the modified nanofibers (4-Fe2O3 and 5-Fe2O3) showed that they have comparable antibacterial activity while the 5-Fe2O3 nanofibers are the best for the photooxidation of methyl orange. The singlet oxygen generation efficiency, high activity, versatility, regenerability and thus reusability of the fabricated hybrid nanofibers makes them ideal candidates for real life water treatment studies.
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- Date Issued: 2022
The synergistic effects of coupling Au nanoparticles with an alkynyl Co (II) phthalocyanine on the detection of prostate specific antigen
- Authors: Nxele, Siphesihle Robin , Nkhahle, Reitumetse , Nyokong, Tebello
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/230232 , vital:49756 , xlink:href="https://doi.org/10.1016/j.talanta.2021.122948"
- Description: Prostate specific antigen (PSA) aptasensors are fabricated using a novel asymmetrically substituted Co phthalocyanine (CoPc), gold nanoparticles (AuNPs) and PSA-specific antigen. The fabricated aptasensors are: GCE-AuNPs-Aptamer, GCE@CoPc-Aptamer and GCE-AuNPs@CoPc-Aptamer (GCE = glassy carbon electrode). The fabricated sensors are characterized at each modification step to monitor the changes occurring at the sensor surface. Concentration studies were carried out using differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) to determine detection limits. All the fabricated aptasensors were found to be highly specific and selective but the GCE-AuNPs@CoPc-Aptamer nanoconjugate performed the best. The aptasensors were also tested in spiked serum samples and detection limits, as well as % recoveries were determined. The results obtained showed that the GCE-AuNPs@CoPc-Aptamer has the potential to be used for clinical studies as the results agree with those obtained for detection of PSA in buffer.
- Full Text:
- Date Issued: 2022
Time-dependent characterization of graphene quantum dots and graphitic carbon nitride quantum dots synthesized by hydrothermal methods
- Authors: Nxele, Siphesihle Robin , Nyokong, Tebello
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/230917 , vital:49831 , xlink:href="https://doi.org/10.1016/j.diamond.2021.108751"
- Description: We report on the facile synthesis of graphene quantum dots (GQDs), nitrogen-doped quantum dots (NGQDs) and graphitic carbon nitride quantum dots (gCNQDs) by the bottom-up hydrothermal synthetic process. The time is varied to study its effects on the structural, hydrodynamic and optical properties of these nanostructures. The techniques used to characterize these nanostructures were transmission electron microscopy, X-ray diffractometry, dynamic light scattering, and zetametry (zeta potential), and by energy dispersive X-ray, UV/vis, fluorescence, Fourier transform infrared, Raman and X-ray photoelectron spectroscopies. For gCNQDs and NGQDs, Raman spectroscopy showed an increase in disorder with synthesis time, indicating introduction of more triazine groups for the former and increase in doping with the N atoms for the latter, hence higher temperatures are recommended. For GQDs, Raman spectra showed an increase in the spatial order of the π-conjugated structure with synthesis time. Considering all the techniques employed in this work, the synthesis times of 6h and 8 h are recommended for GQDs and NGQDs.
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- Date Issued: 2022
Ultrasensitive detection of prostate-specific antigen using glucose-encapsulated nanoliposomes anti-PSA polyclonal antibody as detection nanobioprobes
- Authors: Mwanza, Daniel , Mfamela, Nololo , Adeniyi, Omotayo , Nyokong, Tebello , Mashazi, Philani N
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/300268 , vital:57911 , xlink:href="https://doi.org/10.1016/j.talanta.2022.123483"
- Description: In this work, the preparation of glucose encapsulating nanoliposomes was achieved using two different lipid formulations, labelled as F1 and F2. Both formulations contained phosphatidylcholine (PC), oleylamido-4-butanoic acid (OABA) and in addition, F1 had cholesterol (CHO) while F2 contained cholesteroyl hemisussinate (CHEMS). These formulations were studied for their pH sensitivity and controlled release of encapsulated glucose for indirect detection of prostate-specific antigen (PSA) using sandwich immunoassay. As a signal generator, encapsulated glucose in nanoliposomes was quantified directly using the personal glucose meter (PGM) and colorimetrically using peroxidase property of horseradish peroxidase (HRP) enzyme and Pd|PdO as nanozymes. Controlled release of the encapsulated glucose was achieved using the pH effect or Triton-X 100 as a surfactant to destabilize the liposomal structure. The F2 formulation showed maximum controlled release at acidic phosphate buffer saline (PBS, pH 5.0). The concentration of encapsulated glucose was found to be high in F2 formulation and these were applied for the indirect detection of PSA. The limit of detection (LOD) values for PSA were found to be 53 fg mL−1, 64 fg mL−1 and 10 fg mL−1 when HRP, Pd|PdO and PGM were respectively used. The detection signal was linear over a wide concentration range for PSA including the clinical range of 4–10 ng mL−1. The HRP system showed low LOD value when compared with Pd|PdO nanozymes. PGM system gave lowest LOD values owing to the sensitivity of the system towards glucose. Pd|PdO nanozyme system showed good stability over a wide temperature up to 80 °C. PGM system required less reaction time (2 min), low reagents and results were readily generated in digital format.
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- Date Issued: 2022
A heavy-atom-free π-extended N-confused porphyrin as a photosensitizer for photodynamic therapy
- Authors: Babu, Balaji , Mack, John , Nyokong, Tebello
- Date: 2021
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/185909 , vital:44447 , xlink:href="https://doi.org/10.1039/d1nj00112d"
- Description: The synthesis and characterization of a novel 1,3-diethyl-2-thiobarbituric-acid-substituted N-confused porphyrin (NCP-TB) is reported, along with a study of its photodynamic activity against MCF-7 cells using 530 (110 mW cm−2) and 660 nm (280 mW cm−2) Thorlabs light-emitting diodes for 30 min. The singlet oxygen quantum yield for NCP-TB is 0.38 compared to 0.23 for the parent unsubstituted N-confused porphyrin (NCP) due to the presence of a sulfur atom. NCP-TB exhibits enhanced PDT activity compared to NCP at both wavelengths. A significantly lower IC50 value of 5.2 μM was obtained at 530 nm (14.7 μM at 660 nm) despite a smaller light dose, due to a large red shift of the intense B band into the green region of the spectrum. 2′,7′-Dichlorofluorescein diacetate (DCFDA) assays demonstrate that there is intracellular generation of reactive oxygen species upon exposure to light.
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- Date Issued: 2021
Aluminum corrosion retardation properties of acetamidophenoxy phthalocyanines: Effect of central metal
- Authors: Nnaji, Nnaemeka , Sen, Pinar , Nyokong, Tebello
- Date: 2021
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/185433 , vital:44386 , xlink:href="https://doi.org/10.1016/j.molstruc.2021.130806"
- Description: Corrosion inhibition performances and adsorption behaviour at the aluminum-HCl solution interface were investigated for metal free (2), ClGa (3) and Co (4) tetrakis (4-acetamidophenoxy) phthalocyanine. Electrochemical techniques were used in the study and complemented with Fourier transform infrared, scanning electron microscopy and X-ray diffraction measurements. Potentiodynamic polarization technique gave inhibition efficiency values as 93.3% (2), 69.7% (3) and 87.7% (4) at 28°C at highest inhibitor concentration (10 µM) in the following order 2 > 4 > 3. These compounds exhibited good corrosion inhibition performance as mixed-type corrosion inhibitors. All applied techniques gave results which corroborated.
- Full Text:
- Date Issued: 2021
Amphiphilic axially modified cationic indium-porphyrins linked to hydrophilic magnetic nanoparticles for photodynamic antimicrobial chemotherapy against gram-negative strain; Escherichia coli
- Authors: Makolla, Collen L , Mgidlana, Sithi , Nyokong, Tebello
- Date: 2021
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/185024 , vital:44317 , xlink:href="https://doi.org/10.1016/j.dyepig.2021.109262"
- Description: In this study, we report on the synthesis, characterization, and application of indium porphyrins linked to silver core-shell magnetic nanoparticles for in vitro photodynamic antimicrobial chemotherapy (PACT) against gram-negative strain, E. coli. This work compares the photophysicochemical and PACT activities of InCl 5-p-carboxyphenyl-10-15-20-(tris-4-methylpyridinium)-triiodide porphyrin (1), InCl 5-p-carboxyphenyl-10-15-20-(tris-4-hexylpyridinium)-triiodide porphyrin (2), In (para-aminophenyl) 5,10,15,20-tetrakis(4-methylpyridinium)-tetraiodide porphyrin (3), and In (para-aminophenyl) 5,10,15,20-tetrakis(4-hexylpyridinium)-tetraiodide porphyrin (4). The comparisons were based on the structure and number of charges. Hydrophilic and hydrophobic characters of the amphiphilic porphyrins were studied by comparing the effect of the different alkyl halides (iodomethane and iodohexane) quaternizing agents. The porphyrin complexes were further linked to magnetic nanoparticles to facilitate antimicrobial synergy and recovery of the complexes after use. High Log reduction values ranging from 7.19 to 9.58 were obtained for the quaternized complexes.
- Full Text:
- Date Issued: 2021
Asymmetrical zinc (II) phthalocyanines cobalt tungstate nanomaterial conjugates for photodegradation of methylene blue
- Authors: Mgidlana, Sithi , Nyokong, Tebello
- Date: 2021
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184991 , vital:44314 , xlink:href="https://doi.org/10.1016/j.jphotochem.2021.113421"
- Description: Herein, we present syntheses of three asymmetrical zinc(II) phthalocyanine (ZnPc) complexes and hydrothermal synthesis of cobalt tungstate nanoparticles. The ZnPc derivatives were covalently linked to cobalt tungstate nanoparticles. Photophysical and photochemical behaviour of Pcs and nanoconjugates were investigated. The nanoconjugates generated higher triplet quantum yield and singlet oxygen quantum yield than the ZnPcs alone. Furthermore, in this paper photocatalytic efficiencies of ZnPc complexes and nanoconjugates were investigated for the degradation of methylene blue and higher photocatalytic behaviour was observed for the conjugates. The kinetic model was used to study photocatalytic behaviour of all the prepared photocatalysts.
- Full Text:
- Date Issued: 2021
Ball-type phthalocyanines and reduced graphene oxide nanoparticles as separate and combined corrosion inhibitors of aluminium in HCl
- Authors: Nnaji, Nnaemeka , Nawji, Njemuwa , Mack, John , Nyokong, Tebello
- Date: 2021
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/185421 , vital:44385 , xlink:href="https://doi.org/10.1016/j.molstruc.2021.130279"
- Description: Corrosion inhibition performances and adsorption behaviour at the aluminum-HCl solution interface were investigated for reduced graphene oxide nanosheets (rGONS), tetrakis-[4,4′-((4-(benzo[d]thiazol-2-yl)-1,2-bis(phenoxy)] (diphthalocyaninato gallium (III) chloride) (2) and tetrakis-4-(hexadecane-1,2-dioxyl)-bis(phthalocyaninato gallium(III) chloride) (1). Corrosion inhibition effects of rGONS, 1 and 2 were evaluated alone and in combination in 1.0 M hydrochloric acid solution using electrochemical techniques. The mechanism of aluminum corrosion inhibition revealed predominantly anodic character for rGONS and predominantly cathodic character for 1, 2, and conjugates with rGONS . The polarization technique gave inhibition efficiency values of 96.5% and 96.9% respectively for 1 and 2, which increased in the presence of rGONS to 97.4% and 98.1%, respectively, for the highest concentrations of 1 and 2. Scanning electron microscopy revealed effective metal surface protection by the inhibitors by formation of protective films.
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- Date Issued: 2021
Borneol-triarylcorrole hybrids with chiral-optical response and anticancer behaviours
- Authors: Fu, Bo , Wang, Lin , Yu, Xiaoxiao , Fang, Xianying , Mack, John , Dingiswayo, Somila , Nyokong, Tebello , Liang, Xu , Xu, Haijun
- Date: 2021
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/185294 , vital:44362 , xlink:href="https://doi.org/10.1016/j.dyepig.2021.109699"
- Description: A series of four multifunctional A2B type H3corroles with meso-borneol substituents at the B position have been synthesized and characterized. A detailed analysis of the optical properties was carried out, and a comparison was made with theoretical calculations to identify the key trends in the structure-property relationships. The meso-borneol substituent couples with the corrole core leading to clear CD signals in the B band region. Enhanced anti-cancer properties are observed in vitro relative to (−)-borneol with cell inhibition rates of up to 94%.
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- Date Issued: 2021
Creating the Ideal Push-Pull System for Electrocatalysis A Comparative Study on Symmetrical and Asymmetrical Cardanol-based Cobalt Phthalocyanines
- Authors: Nkhahle, Reitumetse , Nyokong, Tebello
- Date: 2021
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/${Handle} , vital:44452 , xlink:href="https://doi.org/10.1002/elan.202060019"
- Description: A symmetrical cardanol-based cobalt phthalocyanine (Pc) along with its asymmetrical acid-based derivatives were synthesized and applied in the electrocatalysis of hydrazine. Despite the inhibition of electron movement by the bulky cardanol-based substituent throughout the series of molecules, an ideal combination of substituents was established in GCE-3 (2,9,16-tris(3- pentadecylphenoxy)-23-mono propionic acid phthalocyanato cobalt (II)) where a limit of detection (LoD) value of 5.10 μM (signal to noise ratio=5) was recorded for the detection of hydrazine. The results obtained serve as an illustration that the combination of electron-donating and electron-withdrawing substituents has a significant influence on the complete functioning of the phthalocyanine molecule(s) being investigated.
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- Date Issued: 2021
Disilane-bridged architectures with high optical transparency for optical limiting
- Authors: Feng, Hongjie , Zhou, Zhikuan , May, Aviwe K , Chen, Jiaying , Mack, John , Nyokong, Tebello , Gai, Lizhi , Lu, Hua
- Date: 2021
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/190623 , vital:45011 , xlink:href="https://doi.org/10.1039/D1TC01488A"
- Description: A novel tetraphenylethylene (TPE) architecture that makes use of a disilane bridge was developed to successfully prepare organic optical power limiting (OPL) materials with high transparency. The σ-bridged TPE derivatives exhibit enhanced solid-state emission efficacies up to 4 times that of TPE. Due to the unique σ-electron delocalization, the incorporated Si–Si bridge gives rise to intense nonlinear optics (NLO) properties. These compounds show favorable optical transparency in the visible region, since the σ–π interaction has a relatively minor effect on the absorption properties of TPE. The poly(bisphenol A carbonate) (PBC) thin films of disilane-bridged compounds exhibit significant reverse saturable absorbance (RSA) responses during Z-scan measurements at 532 nm. In contrast, negligible OPL properties were observed in tetrahydrofuran (THF) solution and when a PBC thin film was prepared with TPE. The disilane-bridged molecular system represents a novel and easily prepared architecture for the construction of solid-state optical limiting materials.
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- Date Issued: 2021
Effect of ultrasonic frequency and power on the sonodynamic therapy activity of cationic Zn (II) phthalocyanines
- Authors: Nene, Lindokuhle C , Sindelo, Azole , Britton, Jonathan , Nyokong, Tebello
- Date: 2021
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/185737 , vital:44419 , xlink:href="https://doi.org/10.1016/j.jinorgbio.2021.111397"
- Description: We report on the sonodynamic activity of cationic phthalocyanines (Pcs) and the effect of the variation of two parameters: ultrasound frequency and power (Par I (1 MHz, 1 W cm−2), Par II (1 MHz, 2 W cm−2), Par III (3 MHz, 1 W cm−2) and Par IV (3 MHz, 2 W cm−2)) on the efficiency of their reactive oxygen species generation and cancer eradication in vitro thereof. Where Par stands for the various combinations of these parameters. Four Pcs were investigated with substituents bearing diethylamine, ortho- and para-pyridine and morpholine groups. Overall, the para-pyridine and morpholine Pcs showed substantial sono-activity in the various ultrasound parameters with Par I and IV generally showing better singlet oxygen and hydroxyl radicals generation confirmed by electron paramagnetic resonance spectroscopy. In some cases, very high hydroxyl radicals' generation was observed at Par II. Furthermore, the fragmentation of the Pcs after Par II treatments was confirmed using UV–vis and magnetic circular dichroism spectroscopy. The reactive species generation efficacy decreased at Par III for all samples. Ultrasound assisted cytotoxicity of the Pcs was confirmed in vitro using the human (Michigan Cancer Foundation-7) breast cancer cell line.
- Full Text:
- Date Issued: 2021