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Abstract: redressing the apartheid legacy of social exclusion : social equity, redress and admission to higher education in democratic South Africa

  • Authors: Badat, Saleem
  • Date: 2009
  • Language: English
  • Type: Text
  • Identifier: vital:7734 , http://hdl.handle.net/10962/d1015881
  • Full Text:
  • Date Issued: 2009

Access to credit and the effect of credit constraints on household welfare in the Eastern Cape province, South Africa

  • Authors: Baiyegunhi, Lloyd-James Segun
  • Date: 2009
  • Subjects: Rural poor -- South Africa -- Eastern Cape , Households -- Economic aspects -- South Africa -- Eastern Cape , Investments -- South Africa -- Eastern Cape , Finance -- South Africa -- Eastern Cape , Credit -- South Africa -- Eastern Cape , Rural development -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Doctoral , PhD (Agricultural Economics)
  • Identifier: vital:11153 , http://hdl.handle.net/10353/d1000977 , Rural poor -- South Africa -- Eastern Cape , Households -- Economic aspects -- South Africa -- Eastern Cape , Investments -- South Africa -- Eastern Cape , Finance -- South Africa -- Eastern Cape , Credit -- South Africa -- Eastern Cape , Rural development -- South Africa -- Eastern Cape
  • Description: In recent years, concern about food safety linked to health issues has seen a rise in private food safety standards in addition to the regulations set by the Food and Agriculture Organisation (FAO) in collaboration with the World Health Organisation (WHO). These have presented challenges to producers and exporters of agricultural food products especially the producers of fresh fruits and vegetables. In spite of the food safety-linked challenges from the demand side, the vast range of business-environment forces pose equally formidable challenges that negatively impact on the exporting industries’ ability to maintain or improve their market shares and their ability to compete in world markets. The objective of this study was therefore to establish the competitiveness of the South African citrus industry in the international markets within this prevailing scenario. Due to the diversity of the definitions of competitiveness as a concept, this study formulated the following working definition: “the ability to create, deliver and maintain value and constant market share through strategic management of the industrial environment or competitiveness drivers”. This was based on the understanding that the international market shares of an industry are a function of forces in the business environment which range from intra-industry, external and national as well as the international elements. The unit of analysis were the citrus producers engaged in export of their products and the study made use of 151 responses by producers. The study adopted a five-step approach to the analysis of the performance of the South African citrus industry in the global markets, starting with the analysis of the Constant Market Share (CMS) of the South African citrus industry in various world markets, establishing the impact of the business environmental factors upon competitiveness, establishing the costs of compliance with private food safety standards, determining the non-price benefits of compliance with the standards, as well as highlighting the strategies for enhancing long-term competitiveness of the industry in the international markets. South Africa is one of the top three countries dominating the citrus fruit export market. Since its entry into the citrus fruit exports market in the 1900s, the industry has sustained its activity in the international market. The Constant Market Share Analysis shows that, amidst the challenges on the international market side, and the changes in the business environment, over much of which the industry has limited control and influence, the industry has maintained its competitive advantage in several markets. The CMS shows that South Africa’s lemons are competitive in America. Despite a negative trend, the South African grapefruit has been competitive in France, Greece, Italy, the Netherlands and Spain. Oranges have been competitive in the Greece, Italy, Portugal, UK, Asian and Northern Europe markets. Competitiveness in these markets has been due to the inherent competitiveness of the industry. Competitiveness in such markets as the Middle East has been attributed to the relatively rapid growth of these markets. The South African citrus industry has similarly undergone many major processes of transformation. The business environmental factors influencing its performance have ranged reform to the challenges beyond the country’s borders. These factors directly and indirectly affect the performance of the industry in the export market. They have influenced the flow of fruits into different international destinations. Of major concern are the food safety and private standards. Challenges in traditional markets as well as opportunities presented by demand from newly emerging citrus consuming nations have seen a diversification in the marketing of the South African citrus. The intensity of competition in the global market is reflected by the fluctuations in the market shares in different markets as well as the increase and fluctuations of fruit rejection rates in some lucrative markets such as America. A combination of challenging national environmental forces and stringent demand conditions negatively impact on revenues especially from markets characterised by price competitiveness. This study identified cost of production, foreign market support systems, adaptability, worker skills, challenges of management in an international environment and government policies such as labour and trade policies as some of the most influential obstacles to competitiveness. Some of the most competiveness-enhancing factors were market availability, market size, market information, market growth and the availability of research institutions. However, compliance with private standards still poses a challenge to the exporters. The different performance levels of the industry in various markets prove the dissimilarity of the demand conditions in the global market. These are supported by the negative influence associated with the foreign market support regimes as well as the challenges associated with compliance with private food safety standards. While market availability, market growth, market information and size were identified as enhancing competitiveness, the fluctuations and inconsistencies in the competitiveness of the industry in different foreign markets require more than finding markets. Resource allocation by both the government and the industry may need to take into account the off-setting of the national challenges and support of farmers faced with distorted and unfair international playing fields. Otherwise, market availability is not a challenge for the industry save meeting the specifications therewith as well as price competitiveness which is unattainable for the South African citrus producers faced with high production costs. For the purposes of further study, it is recommended that account should be taken of all the products marketed by the industry (including processed products such as fruit juices) in order to have a whole picture of the competitiveness of the industry in the international market. This study also proffers a new theoretical framework for the analysis of the business environment for the citrus industry and other agro-businesses. This framework takes into account the indispensability of the food safety standards and measures as well as the diversity of the global consumer and the non-negotiability of food trade for the sustenance of the growing population.
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  • Date Issued: 2009

Adapting retail business models for the petroleum industry

  • Authors: Tait, Hennie Leon
  • Date: 2009
  • Subjects: Petroleum products -- Prices , Petroleum industry and trade -- South Africa , Petroleum industry and trade -- Economic aspects -- South Africa
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: vital:8689 , http://hdl.handle.net/10948/1110 , Petroleum products -- Prices , Petroleum industry and trade -- South Africa , Petroleum industry and trade -- Economic aspects -- South Africa
  • Description: Deregulation as an open market system is likely to be implemented in the Petroleum industry of South Africa. To secure the success of the retail petroleum industry by means of business and job opportunities one has to investigate the current evolution of the industry and what factors will have a measurable impact on the retail petroleum industry.
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  • Date Issued: 2009

Adaptive interfaces for mobile preference-based searching

  • Authors: Hill, Ryan Tebbutt
  • Date: 2009
  • Subjects: User interfaces (Computer systems) -- South Africa , Mobile computing -- South Africa , Global Positioning System , Global system for mobile communications -- South Africa
  • Language: English
  • Type: Thesis , Masters , MCom
  • Identifier: vital:9259 , http://hdl.handle.net/10948/1248 , User interfaces (Computer systems) -- South Africa , Mobile computing -- South Africa , Global Positioning System , Global system for mobile communications -- South Africa
  • Description: Today's mobile computing devices provide a convenient means to search for points-of-interest (POIs) such as restaurants and accommodation. Mobile Preference-Based Search Tools (PBSTs) allow users to identify POIs such as restaurants or accommodation most suited to their needs and constraints using a mobile device. These devices however, have several design constraints including limited screen space and hardware capabilities. Adaptive User Interfaces (AUIs) have been proposed to address these issues but have not been extensively applied to mobile PBSTs such as mobile tourist guides. In addition, AUIs possess several benefits and advantages over static (traditional) interfaces, which do not take a user's preferences, skill set and experience into account. Little research, however, has been conducted into identifying the potential benefits of AUIs for mobile preference-based searching (PBS). The aim of this research was to determine the extent to which an AUI could improve the effectiveness and user satisfaction of mobile PBS. A literature study was conducted to determine the benefits and limitations of existing mobile PBSTs and determine how these could be improved. The potential benefits of AUIs for mobile PBSTs and a mobile map-based visualisation system were identified. A suitable model for incorporating an AUI into a mobile PBST was identified. The requirements for a mobile PBST were combined with the potentially adaptable objects of a Mobile Map-based Visualisation (MMV) system to provide adaptation suggestions for POInter, an existing mobile tourist guide. A field study using POInter was conducted in order to measure the extent to which participants agreed with suggestions provided for adapting the information, interaction and visualisation aspects of the system. These results were used to derive adaptation requirements for A-POInter, an adaptive version of POInter. Using a model-based design approach, an AUI was designed and implemented for A-POInter. An extensive field study was then conducted to evaluate the usability of the adaptations provided by A-POInter. The quantitative and qualitative data collected from the evaluations allowed the usability of A-POInter to be determined. The results of the field study showed that the participants were highly satisfied with the usability and the usefulness of the adaptations provided by A-POInter. Conclusions and recommendations for future work based on the results of the research were then outlined to conclude the dissertation.
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  • Date Issued: 2009

Addressing the digital divide through the implementation of a wireless school network

  • Authors: Du Preez, Creswell
  • Date: 2009
  • Subjects: Educational technology -- South Africa , Information technology -- Social aspects -- South Africa
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:9758 , http://hdl.handle.net/10948/1298 , Educational technology -- South Africa , Information technology -- Social aspects -- South Africa
  • Description: Societal trends have changed more in the last decade than they have in the last century. This is particularly prevalent in the education environment. Concepts such as Lifelong Learning (the continued learning/educating of an individual throughout his/her lifetime), New Competencies (technology that is now part of almost every skill in the workplace) and Telecommuting (more people working from home rather than traditional offices) have become common-place today (Twigg, 1996, pp. 1-2). Education delivery needs to provide for these societal changes in order to ensure competent individuals pass on to the next level of education and ultimately to the work force. With key trends in technology such as Digitization, Maturation and Disintermediation becoming common in the workplace, education delivery must address the ―Digital Divide. (Twigg, 1996, pp. 2-3). Historically, schools in South Africa have used traditional teaching methods that have stayed the same for the last century. Educational institutions in South Africa, in particular, the previously disadvantaged schools of the Eastern Cape, face various challenges such as the dwindling ability to collect school fees from parents of scholars and declining financial support from the government. In Chapter Seven of the Draft White Paper on e-Education, which was gazetted on 26 August, 2004, the DoE, as part of its implementation strategies, urged the private sector to respond by implementing ICT initiatives nationwide. Phase 1 of the strategy advocated that ―Institutions are connected, access the internet and communicate electronically. (Department of Education, 2004, pp. 37-40). This dissertation shows that it is feasible to create a communications’ network among South African schools. It is believed that such a network can add great value to the education system in South Africa. The potential for this network to address the gap in the Digital Divide is enormous. This dissertation examines various ICT communications’ technologies and isolates wireless communications’ technology as best suited for this purpose, due to the speeds offered by the technology and the cost structure associated with it. A case study examines a pilot installation of the network and endeavours to prove the concept.
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  • Date Issued: 2009

Addressing the idiosyncrasies of contemporary notation in recorder compositions, with specific references to unconventional symbols in Music for a bird by Hans-Martin Linde and Sieben Stucke fur altblokflote by Markus Zahnhausen

  • Authors: Bartle, Lynne
  • Date: 2009
  • Subjects: Musical notation , Musical notation -- Study and teaching , Musical notation -- History , Music -- 20th century
  • Language: English
  • Type: Thesis , Masters , MMus
  • Identifier: vital:8516 , http://hdl.handle.net/10948/920 , http://hdl.handle.net/10948/d1012065 , Musical notation , Musical notation -- Study and teaching , Musical notation -- History , Music -- 20th century
  • Description: This treatise provides recorder performers and teachers with a guide to understanding the unconventional notation symbols encountered in Music for a Bird by Hans-Martin Linde and Sieben Stücke Für Altblockflöte by Markus Zahnhausen. Given the context of the overall history of notation, it argues that the idiosyncrasies of the unconventional notation symbols encountered in the recorder repertoire of contemporary composers such as Linde and Zahnhausen are by no means an anomaly. Throughout history, notated scores have functioned merely as incomplete guides to the reconstruction and the realization of musical works. Along with the decoding of these instructions, a host of acculturated meanings have always been taken for granted on the part of the writers of such guidelines. In the light of the modernist crisis and the resultant exacerbation of the gulf between composers and their audience, however, it would seem that the need for such acculturated intervention is greater then ever before. This treatise serves to bridge the gulf between the works of Linde and Zahnhausen on the one hand, and the average performer and teacher of the recorder on the other, by offering an analysis both of the meaning of the unconventional symbols these works contain as well as of the method according to which they should be executed on the recorder.
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  • Date Issued: 2009

Adequacy of the postgraduate certificate in education at higher education institutions in the Eastern Cape to develop the work-intergrated learning skills of student teachers

  • Authors: Mahomed, Carmel Claire
  • Date: 2009
  • Subjects: Teachers -- Certification -- South Africa -- Eastern Cape , Teachers -- Training of -- South Africa -- Eastern Cape , Teachers -- Rating of -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Masters , MEd
  • Identifier: vital:9521 , http://hdl.handle.net/10948/1008 , Teachers -- Certification -- South Africa -- Eastern Cape , Teachers -- Training of -- South Africa -- Eastern Cape , Teachers -- Rating of -- South Africa -- Eastern Cape
  • Description: This study investigated whether the PGCE adequately develops the WIL skills of student teachers. WIL skills have contributed extensively to the effectiveness of the facilitation of teaching and learning in schools. The definitions of WIL in this study refer to the skills required to succeed in practice. The four domains of Danielson provide the WIL skills, namely Preparation and Planning, the School Environment, Instruction and Professional Responsibilities. The study showed that there is a link between the four domains and the capacity of student teachers to integrate the theory they acquire at the HEIs and practice in the schools. The quantitative approach is referred to by Creswell (2005:39) as a type of educational research in which the researcher decides what to study, asks specific narrow questions, collects numeric data, which is numbered data from participants, analyzes these numbers using statistics, and conducts the inquiry in an unbiased, objective manner. As this study requires numeric data that ask specific questions, two questionnaires were distributed. One questionnaire was directed at school – based mentors and the other at PGCE student teachers. The mentors rated the students’ capacity in the four domains and the students rated themselves on the same items based on the four domains. The research instrument provides insight from school-based mentors with regard to whether there is a balance between the theoretical knowledge provided by HEIs and the WIL skills that student - teachers need. The questionnaires completed by PGCE student teachers provided perspectives from the students with regard to the relevance of their WIL skills for the schools at which they were placed. The hypothesis for this study is: The PGCE makes a significant contribution to the development of the WIL skills of ITE student teachers. Some of Some of the key findings in this study indicated that: • Constant curriculum changes in the schools create uncertainty for student teachers. • Student teachers need assistance to motivate learners to take pride in their work and achievements. • Managing learner behaviour is cause for concern for student teachers. • Language proficiency continues to be problematic in the teaching and learning environment, because it impacts on questioning, discussion techniques and the student teachers’ capacity to explain concepts. • Student teachers need assistance with the pacing of their lessons. • Adjusting their lessons, which requires spontaneity from student teachers is needed. • Opportunities need to be created for student teachers to gain access to the parents of their learners. • Student teachers need to devote more time to the development of reflective skills. • Excessive administrative tasks hamper delivery in the classroom and teacher and learner productivity. The findings strongly suggested that a significant relationship exists between the WIL skills of PGCE students and their effectiveness as facilitators of learning. The findings of the study indicated that the PGCE curriculum needs to incorporate the crucial WIL skills as identified in the four domains. The findings of this study supported the hypothesis that the PGCE makes a significant contribution to the development of the WIL skills of Initial Teacher Education student teachers (ITE).
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  • Date Issued: 2009

Adherence and non-adherence to antiretroviral treatment in HIV people in Port Elizabeth

  • Authors: Masokoane, Kgomotso Quentinne
  • Date: 2009
  • Subjects: Antiretroviral agents -- South Africa -- Port Elizabeth , HIV infections -- Treatment -- South Africa -- Port Elizabeth , AIDS (Disease) -- Treatment -- South Africa -- Port Elizabeth
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:9886 , http://hdl.handle.net/10948/1185 , Antiretroviral agents -- South Africa -- Port Elizabeth , HIV infections -- Treatment -- South Africa -- Port Elizabeth , AIDS (Disease) -- Treatment -- South Africa -- Port Elizabeth
  • Description: The introduction of antiretroviral drugs (ARVs) in 1996 transformed the treatment of HIV and AIDS, improving the quality and greatly prolonging the lives of many infected people. HIV (Human Immunodeficiency Virus) is the virus that is believed to cause AIDS. AIDS (Acquired Immune Deficiency Syndrome) is the collection of illnesses or symptoms that ultimately results in death. Antiretroviral (ARVs) drugs or Highly Active Antiretroviral Therapy (HAART) is the treatment that has been applied to combat the HI virus in a bid to slow down the progression of AIDS and ultimately prolong the life of the infected individual. The study aimed to explore and describe the factors contributing to adherence and non-adherence to ARVs in individuals on treatment. A sample of 81 individuals who have been on ARV and HAART treatment for six months or more was used. The methodology used was exploratory-descriptive and the data obtained was quantitative in nature. A biographical questionnaire and questionnaire with questions aimed at ascertaining the possible factors that contribute to individuals either adhering to or defaulting on their treatment, such as side effects and cost of treatment, was administered. The data obtained was analysed by means of descriptive statistics and frequency counts. The results of the study showed that the sample had a fairly high level of adherence. The factors that could undermine adherence were identified as lack of support, as familial and health provider support acts as a motivator to adhere; substance abuse as it can lead to forgetting to take treatment; unemployment and poverty, as these can lead to an inability to return for follow up clinic visits or failure to have food to take with the pills; and the type of treatment regimen whereby the more complex the treatment is the more likely it is that adherence will be difficult to maintain. Suggestions were made as to future research involving antiretroviral therapy (ART). Finally the limitations as well as the value of the research were outlined.
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  • Date Issued: 2009

Advances in platinum-amine chemotherapeutic agents : their chemistry and applicationc

  • Authors: Jaganath, Yatish
  • Date: 2009
  • Subjects: Coordination compounds , Antineoplastic antibiotics , Cancer -- Chemotherapy
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:10446 , http://hdl.handle.net/10948/d1021222
  • Description: The research conducted in this study focussed on advancing the knowledge database of diamineplatinum complexes on two frontiers: 1) the development of novel anticancer complexes, and 2) improvements in their synthetic chemistry. Novel square-planar dichloro and oxalato platinum(II) complexes were synthesized as potential anticancer agents in accordance with a comprehensive set of factors identified as being significant in optimizing such action. The nonleaving ligands consisted of asymmetric chelating chiral diamines of the form 1- (1-R-imidazol-2yl)(R')methanamine (R representing methyl, butyl and R' methyl, phenyl). The complexes were characterized by a host of spectral, thermal and crystallographic techniques. In addition, the stabilities of the complexes were monitored in aqueous and saline solutions. Cytotoxicity screening on three cultured cancer cell lines (MCF-7, HeLa and HT29) indicated the compounds, present as their respective racemates, to have rather modest activities relative to cisplatin; with complexes having the smallest substituents, R,R' = methyl, being most active. In recognition of the limitations of traditional silver-based syntheses of oxalatoplatinum(II) complexes, innovative non-silver methods were developed using the well known cancer drug, oxaliplatin, (trans-R,R-1,2- diaminocyclohexane)oxalatoplatinum(II), as a prototype. These involved direct ligand exchange reactions of the dichloro precursor, (trans-R,R-1,2- diaminocyclohexane)dichloroplatinum(II), with tetrabutylammonium oxalate in essentially non-aqueous solvents. A 90:10 mixture of isoamyl alcohol (3-methyl- 1-butanol):water, proved to be a promising solvent, enabling the recovery of pure oxaliplatin (~98 percent) after 9 hours at 88 °C in yields of up to 86 percent. In light of the perceived unique mode of anticancer action available to mononitroplatinum(IV) complexes (i.e. their STAT3-binding potential), octahedral diamineoxalatoplatinum(IV) complexes containing axially-coordinated nitro and halo co-ligands were synthesized and extensively characterized. Electrochemical studies revealed trends in reduction potential which could be correlated to structural / chemical traits of the coordinated diamine and axial ligands. The similarities of the determined cytotoxicities of the platinum(IV) compounds and their respective platinum(II) analogues, implicated reduction as a means of activation of the platinum(IV) complexes.
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  • Date Issued: 2009

Aes white paper: Best practices in network audio

  • Authors: Bouillot, Nicolas , Cohen, Elizabeth , Cooperstock, Jeremy R , Floros, Andreas , Fonseca, Nuno , Foss, Richard , Goodman, Michael , Grant, John , Gross, Kevin , Harris, Steven , Harshbarger, Brent , Heyraud, Joffrey , Jonsson, Lars , Narus, John , Page, Michael , Snook, Tom , Tanaka, Atau , Trieger, Justin , Zanghieri, Umberto
  • Date: 2009
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/427181 , vital:72420 , https://www.aes.org/e-lib/browse.cfm?elib=14839
  • Description: Analog audio needs a separate physical circuit for each channel. Each microphone in a studio or on a stage, for example, must have its own circuit back to the mixer. Routing of the signals is inflexible. Digital audio is frequently wired in a similar way to analog. Although several channels can share a single physical circuit ( e. g., up to 64 with AES10 ), thus reducing the number of cores needed in a cable. Routing of signals is still inflexible and any change to the equipment in a location is liable to require new cabling. Networks allow much more flexibility. Any piece of equipment plugged into the network is able to communicate with any other. However, installers of audio networks need to be aware of a number of issues that affect audio signals but are not important for data networks and are not addressed by current IT networking technologies such as IP. This white paper examines these issues and provides guidance to installers and users that can help them build successful networked systems.
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  • Date Issued: 2009

African traditional medicines-antiretroviral drug interactions: the effect of African potato (Hypoxis hemerocallidea) on the pharmacokinetics of efavirenz in humans

  • Authors: Mogatle, Seloi
  • Date: 2009
  • Subjects: Potatoes -- Africa Potatoes -- Therapeutic use Medicinal plants Traditional medicine AIDS (Disease) -- Treatment HIV infections -- Drug therapy Drug interactions Antiretroviral agents Pharmacokinetics Hypoxidaceae -- Therapeutic use High performance liquid chromatography
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:3773 , http://hdl.handle.net/10962/d1003251
  • Description: African Potato (Hypoxis hemerocallidea), (AP) is an African traditional medicine (TM) that is commonly used for various nutritional/medicinal purposes and also by people infected with the human immuno deficiency virus HIV and AIDS patients as an immune booster. The use of AP has also been recommended by the former Minister of Health of South Africa for use by HIV positive people. The main phytochemical component of AP is a norlignan glucoside, hypoxoside, and other relatively minor components have also been reported. A recent in vitro study reported the effects of AP extracts, hypoxoside and rooperol (the metabolite of hypoxoside) on human metabolic enzymes such as the cytochrome P450 (CYP450) group of enzymes and also on the transporter protein, p-glycoprotein (P-gp). This research focussed on investigating the clinical significance of those in vitro effects on the pharmacokinetics of efavirenz (EFV) in humans. EFV was chosen as the substrate drug because it is in first-line regimen of treatment of HIV/AIDS in South Africa, and also has been reported to be a substrate for the specific CYP isozymes, 3A4 and 2B6, in common with APs metabolic involvement with 3A4. A high performance liquid chromatography method with ultra-violet detection (HPLC-UV) for the quantitative determination of EFV in plasma was developed and successfully validated according to international standards with good reproducibility, accuracy, recovery, linear response and requisite sensitivity. The preparation of the plasma samples for analysis was effected by using a simple and rapid precipitation method, and the mobile phase consisted of readily available solvents. EFV in plasma samples was found to be stable under the relevant storage conditions studied. The oral dose of AP, administered as a freshly prepared traditional decoction, was standardised based on the hypoxoside content, and the quality of all the AP decoctions was analysed immediately prior to administration, using a validated HPLC-UV method. A single dose, two-phase sequential study was conducted over a period of 31 days in 10 healthy volunteers. The clinical study was approved by the Rhodes University Ethical Standards Committee, and all the participants agreed to the conditions of the study by giving their informed consent. On day 1 of the study, human subjects were administered a 600 mg EFV tablet and blood samples were collected before dosing and at various intervals over a period of 48 hr post dosing. From day 16, a traditionally prepared AP decoction was administered daily at a standardized dose of 15 mg/kg/day per subject until day 30. On day 29, volunteers were administered a single 600 mg dose of EFV as was done on day 1. Plasma samples were harvested immediately after blood sample collection and frozen at -80 ºC until assayed. Geometric mean ratios of relevant pharmacokinetic parameters, Cmax (maximum plasma concentration achieved following dosing) and AUC0-48 (area under the curve of a plot of drug plasma concentrations versus time representing the extent of absorption) of EFV before and after co-administration of 14 successive daily doses of AP were compared and evaluated to determine whether an interaction had occurred. All subjects completed the study and the geometric mean ratios of Cmax and AUC0-48 were 97.30 and 102.82 with corresponding 90% confidence intervals (CIs) of 78.81-120.14% and 89.04-118.80%, respectively. Whereas the acceptance criteria for the ratios of the AUCs fell within the preset 90% CIs indicating no interaction, the Cmax ratios fell outside the limits. Although the protocol was developed in accordance with the United States of America Food & Drug Administration’s Guidance for Drug Interactions, a priori stating that both criteria need to fall within the acceptance limits to indicate no interaction, an argument is presented to waive the Cmax requirement for the declaration of an interaction. As a result, the pharmacokinetic data generated during this study indicated that the effect of AP on the pharmacokinetics of EFV is not clinically significant. Hence, co-administration of AP is unlikely to affect the clinical use of EFV. In summary the objectives of this project were: 1. To develop and validate a suitable HPLC-UV method for the quantitative determination of EFV in plasma. 2. To perform a mini-validation of the determination of hypoxoside for use as a marker in the quality control and standardisation of AP decoctions. 3. To conduct a clinical interaction study in order to determine whether AP affects the pharmacokinetics of EFV following concurrent administration. 4. To apply the validated HPLC-UV method to determine plasma concentrations of EFV in plasma of human subjects. 5. To use appropriate statistical methods and treatments such as a non-compartmental pharmacokinetic analysis to determine the occurrence of an interaction.
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  • Date Issued: 2009

Alan Peacock and Ilde Rizzo: the heritage game

  • Authors: Snowball, Jeanette D
  • Date: 2009
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/71470 , vital:29856 , https://doi.org/10.1007/s10824-009-9106-2
  • Description: The Heritage Game has an ambitious aim: to persuade those engaged in heritage management that economists have a valuable contribution to make and that they should be allowed to join the table where decisions are made—not as occasional “hired guns” consulting on specific matters, but as routine and continuous contributors to the discussion. As such, the book explains and illuminates some of the fundamental ideas in economics (consumer sovereignty, moral hazard, incentives, opportunity cost) as applied to the “heritage biz”. It is written in a light-hearted style that fulfils the authors’ intention of “making economics palatable and even enjoyable … offering both instruction and entertainment” (p. 10). Even economists familiar with the field will thus find it a pleasurable read, filled as it is with humorous anecdotes and examples drawn from the authors’ personal experiences as contributors to heritage management and policy.
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  • Date Issued: 2009

Alternative practices used by resource-limited farmers to control fleas in free-range chickens in the Eastern Cape province, South Africa

  • Authors: Moyo, Sipho
  • Date: 2009
  • Subjects: Fleas -- Control -- South Africa -- Eastern Cape , Insect baits and repellents -- South Africa -- Eastern Cape , Insecticides -- South Africa -- Eastern Cape , Chickens -- Parasites -- South Africa -- Eastern Cape , Parasites -- Control -- South Africa -- Eastern Cape , Chickens -- Diseases -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Masters , MSc Agric (Animal Science)
  • Identifier: vital:11802 , http://hdl.handle.net/10353/393 , Fleas -- Control -- South Africa -- Eastern Cape , Insect baits and repellents -- South Africa -- Eastern Cape , Insecticides -- South Africa -- Eastern Cape , Chickens -- Parasites -- South Africa -- Eastern Cape , Parasites -- Control -- South Africa -- Eastern Cape , Chickens -- Diseases -- South Africa -- Eastern Cape
  • Description: Fleas are one of the major external parasites affecting free range chickens, causing irritation, tissue damage, blood loss and toxicosis which in turn affect quality and quantity of meat and egg production. There are many commercial insecticides available that are effective against fleas. These commercial insecticides have, however become expensive to most resourcelimited farmers and therefore unaffordable, causing farmers to seek low cost alternatives. This study was conducted to document, determine the existence of external parasites in freerange chickens and validate the alternative remedies used in controlling free-range chicken fleas by resource-limited farmers. A questionnaire survey was used to collect data on external parasites of free-range chickens and ethno-veterinary control remedies used by resourcelimited farmers to control these parasites at Amatola basin, in Eastern Cape, South Africa. Resource-limited farmers perceived that mites (79.6%), fleas (64.5%), lice (10.8%) and ticks (6.5%) were problematic parasites of chickens. To control these parasites, resource-limited farmers commonly use ash (28%) madubula (13% carbolic acid) (26.7%), Jeyes fluid (13% carbolic acid) (10%), paraffin (8.4%), used engine oil (2.8%), plants Tagetes minuta, Clutia pulchella, Calpurnia aurea (5.2%) and a few (4.2%) used commercial drugs Karbadust (Carbarly 5%) and mercaptothion 5%. About 7.5% of the respondents used neither of the remedies. To confirm the farmers’ perception on problematic external parasites of free-range chickens a diagnostic survey was conducted. Fifty free-range chickens were randomly selected and examined for external parasites. About 96% of the free-range chickens examined harboured at least one species of external parasites. Fleas (Echidnophaga gallinacea) (50.7%) were the most prevalent followed by lice, Menopon gallinae (12.4%); Menacanthus stramineus (5.3%) and Knemidocoptes mutans (0.57%). Given that Jeyes fluid, used engine oil, paraffin, C. aurea, C. pulchella and T. minuta were mainly used in controlling these parasites, it was important to determine the potential dermal irritant effects of these plants. A dermal irritant effect test was, therefore, conducted using a rat model. Forty eight rats, with parts of the backs shaven, were used to screen the materials for irritation. All the materials tested did not cause any visible skin irritation on rats (p>0.05). Regarding that ethnoveterinary materials were non irritant on rat skin in vitro repellency and contact bio-assay models were used to assess the insecticidal properties of Tagetes minuta, Calpurnia aurea, Clutia pulchella, used engine oil, paraffin and Jeyes fluid on fleas. For the in vitro bioassay T. minuta and Jeyes fluid at 100% concentration demonstrated a repellency level of 76 and 83%, respectively. Tagetes minuta was the most effective among plant materials (p<0.05). Clutia pulchella, C. aurea, used engine oil and paraffin showed insignificant repellency (p>0.05). For the contact bio-assay, C. pulchella, C. aurea and T. minuta at a concentration of 100% resulted in flea mortality of 83.5, 73.3 and 42.5%, respectively. The efficacy of Clutia pulchella compared well with that of Karbadust which had a mean mortality of 97.5%. Paraffin, used engine oil, and Jeyes fluid (19.2%) caused higher flea mortality of more than 82%. In the in vivo study 60 free-range chickens were artificially infested with fleas and test materials were topically applied on infested sites. Test materials exhibited varying flea load reduction efficacy. Used engine oil and Jeyes fluid at 76.8% concentration had a reduction efficacy of 100 and 96% after 3 days post application of test materials. These were not significantly different to that of the positive control Kabadust (carbaryl 5%). The plants C. pulchella and C aurea at 100% concentration had an efficacy of 92 and 77%, respectively. The commonly used remedies by resource-limited farmers to control fleas vary in efficacy. Some of the materials are as effective as the commercial insecticides hence they have a potential to be exploited as insecticides. Further investigations on plant compounds with insecticidal properties and their toxicity, need to be conducted before the plants are recommended for use.
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  • Date Issued: 2009

Ameliorating poverty in South Africa through natural resource commercialisation : how can NGO's make a difference?

  • Authors: Shackleton, Sheona E
  • Date: 2009
  • Language: English
  • Type: Article
  • Identifier: vital:6615 , http://hdl.handle.net/10962/d1016222
  • Description: [From Introduction] Some of the poorest rural people in South Africa are turning to the natural resource base for income generation. Using traditional skills they are converting a variety of wild resources into commodities that are sold in the market place. Wood and woven craft, medicines, fresh and processed wild foods, alcoholic beverages, building materials, fuelwood, dried mopane worms, cultural artefacts and brooms are just some examples of the array of natural resource products increasingly seen for sale in local and external markets. Many of the participants in this trade have minimal education, few assets to draw on, and little access to alternative sources of income or jobs. A significant proportion are women, with more than half heading their own households. Many come from households devastated by HIV/AIDS. The cash earned from selling natural resource products, however modest, is of critical importance to the households involved, preventing them from slipping deeper into poverty. “Since I have been making brooms my children no longer go to bed crying of hunger” observed one broom producer. NGOs, particularly those involved in rural development, can play an important role in assisting producers overcome some of the obstacles they face and in enhancing the opportunities to grow this informal sector. , This policy brief is based on the original brief made available for a workshop in August 2006. It draws on, amongst other sources, the results of several case studies of natural resource commercialisation undertaken across South Africa. The project was funded by the South Africa-Netherlands Programme on Alternatives in Development (SANPAD), BP South Africa and the National Research Foundation (NRF). The Center for International Forestry Research, with support from SIDA, provided the funding to share these findings with key stakeholders including government policy and decision makers.
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  • Date Issued: 2009

An account of the life of Captain Samuel Jervois

  • Authors: Jervois, W
  • Date: 2009
  • Language: English
  • Type: Article
  • Identifier: vital:7005 , http://hdl.handle.net/10962/d1008380
  • Description: [From the introduction]: In this paper, an attempt is made to link the known details of the life of Samuel Jervois with a chain of hypotheses that are based on a study of the people, places and events that made up the environment in which he lived.
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  • Date Issued: 2009

An analysis of collective bargaining arrangements in the construction industry

  • Authors: BWI
  • Date: 2009
  • Subjects: BWI
  • Language: English
  • Type: text
  • Identifier: http://hdl.handle.net/10962/135556 , vital:37275
  • Description: The BWI is the global union federation grouping of free and democratic unions, with members in the building, building materials, wood, forestry and allied sectors. The BWI groups together around 318 trade unions representing around 12 million members in 130 countries. The headquarters is in Geneva, Switzerland. Regional and Project offices are located in Panama and Malaysia, South Africa, India, Australia, Burkina Faso, Bulgaria, Lebanon, Kenya, South Korea, Russia, Argentina, Peru and Brazil. Our mission is to promote the development of trade unions in our sectors throughout the world, and to promote and enforce workers' rights in the context of sustainable development. The President of the International is Klaus Wiesehiigel from the Building and Forest Workers Union in Germany. The Deputy President is Stefaan Vantourenhout from the Building and Wood Workers union in Belgium and the General Secretary is Anita Normark from Sweden.
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  • Date Issued: 2009

An analysis of logical network distance on observed packet counts for network telescope data

  • Authors: Irwin, Barry V W , Barnett, Richard J
  • Date: 2009
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/428090 , vital:72485 , https://www.researchgate.net/profile/Barry-Ir-win/publication/228765119_An_Analysis_of_Logical_Network_Distance_on_Observed_Packet_Counts_for_Network_Telescope_Data/links/53e9c5e80cf28f342f414988/An-Analysis-of-Logical-Network-Distance-on-Observed-Packet-Counts-for-Network-Telescope-Data.pdf
  • Description: This paper investigates the relationship between the logical distance between two IP addresses on the Internet, and the number of packets captured by a network telescope listening on a network containing one of the addresses. The need for the computation of a manageable measure of quantification of this distance is presented, as an alterna-tive to the raw difference that can be computed between two addresses using their Integer representations. A number of graphical analysis tools and techniques are presented to aid in this analysis. Findings are pre-sented based on a long baseline data set collected at Rhodes Universi-ty over the last three years, using a dedicated Class C (256 IP address) sensor network, and comprising 19 million packets. Of this total, 27% by packet volume originate within the same natural class A network as the telescope, and as such can be seen to be logically close to the collector network.
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  • Date Issued: 2009

An analysis of perceived and operationalised team effectiveness in community-based organisations within the Nelson Mandela Metropolitan area: a case study

  • Authors: Gititu, Diana Wambui
  • Date: 2009
  • Subjects: Teams in the workplace -- South Africa -- Port Elizabeth , Community-based organisations -- South Africa -- Port Elizabeth , Management committees -- South Africa -- Port Elizabeth
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:16144 , http://hdl.handle.net/10948/908 , Teams in the workplace -- South Africa -- Port Elizabeth , Community-based organisations -- South Africa -- Port Elizabeth , Management committees -- South Africa -- Port Elizabeth
  • Description: Literature on effectiveness indicates the interest of researchers in the role that teams play within organisations. The conclusion is that different variables affect team performance effectiveness. A further analysis of literature on team effectiveness enabled the researcher to develop a matrix of assessment of team effectiveness from these variables to serve as a benchmark. In addition to this, a matrix consisting of perceived variables of team effectiveness was constructed from the outcome of in-depth interviews and focus group sessions with the members of management committees of community-based organisations (CBOs) based within Port Elizabeth townships. These matrixes were used by the researcher to assess the operationalisation of these variables within the CBO management committees. The research indicates that management committees either did not operationalise these variables within their teams or did not do so to their fullest capacity. The overall outcome of these assessments indicates the areas that require attention, and provides opportunity for group practitioners to assist CBO management committees to enhance their effectiveness as teams. It is suggested that group practitioners together with members of CBO management committees, embark as a task team project to develop a strategy to refine the perceived variables guided by those emphasised by experts within this field, to strategise a clear path towards enhanced team effectiveness.
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  • Date Issued: 2009

An analysis of perceptions and attitudes to the study of IsiXhosa at tertiary level: NMMU a case study

  • Authors: Somhlahlo, Ruby Xoliswa
  • Date: 2009
  • Subjects: Nelson Mandela Metropolitan University -- Students -- Attitudes , Xhosa language -- Study and teaching (Higher) -- South Africa -- Port Elizabeth , Language and education -- South Africa
  • Language: English
  • Type: Thesis , Doctoral , DLitt
  • Identifier: vital:8461 , http://hdl.handle.net/10948/863 , Nelson Mandela Metropolitan University -- Students -- Attitudes , Xhosa language -- Study and teaching (Higher) -- South Africa -- Port Elizabeth , Language and education -- South Africa
  • Description: This study is about the analysis of perceptions and attitudes concerning the study of isiXhosa at tertiary level Nelson Mandela Metropolitan University (NMMU) in Port Elizabeth. The objective of this study is to investigate negative attitudes of African students with special reference to isiXhosa. Chapter One looks at the objectives of the research, the research problem, and its theoretical framework, as well as the literature review, the significance of the study, the research methods and definition of terms. Chapter Two deals with language planning and the current negative attitudes towards African languages, with special reference to isiXhosa. Chapter Three deals with status planning, the teaching of isiXhosa, language maintenance and multilingual education policy. Chapter Four discusses corpus planning, the role that Xhosa educators and students should play in the development of the language. Chapter Five discusses acquisition planning, the attitudes towards isiXhosa language and the maintenance of the language. Chapter Six concludes the study by presenting the summary and recommendations for the future research.
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  • Date Issued: 2009

An analysis of the 2007 general elections in Kenya: a political leadership perspective

  • Authors: Wanjiru, Stephanie M
  • Date: 2009
  • Subjects: Elections -- Kenya , Kenya -- Politics and government
  • Language: English
  • Type: Thesis , Masters , MPhil
  • Identifier: vital:8170 , http://hdl.handle.net/10948/1082 , Elections -- Kenya , Kenya -- Politics and government
  • Description: On 27 December, 2007, Kenyan citizens took to the polls for the fourth time since multiparty democracy was introduced in 1992. The sentiment was that democracy was finally coming of age in this East African country. For many, these elections represented a turn in the country’s democratic process that would bring change in the areas of justice, food, shelter, education and employment to all – as these were the main campaign promises. Instead, at the conclusion of the voting and at the beginning of the tallying process, the electorate erupted violently at the suspicion and eventual reporting of the process being rigged. One of the main subjects discussed in this study includes the argument that Kenya is ailing from a lack of responsible political leadership. The breed of Kenyan politicians that have been experienced in the country since it gained its independence from British colonialists in 1963, have plundered its resources – material and human – to the brink of war. It is no longer a valid argument that Africa, just because of a history of governments looting and plundering the vast resources that belong to the world’s poorest of the poor, in particular Kenya produces bad leaders. The second topic of discussion in this study questions the role of ethnic mobilisation during the elections. It is well documented by authors such as Cowen and Kanyinga (in Cowen and Laakso (eds.) 2002: 128-171) that ethnicity in Kenya, under the machinations of irresponsible political leaders, has in the past played a critical part in rallying one political party against another. The 2007 General Election was no different. The contested presidential election results were announced on 30 December, 2007, declaring another term of office for the incumbent president, Mwai Kibaki. Since that announcement, thousands of people were reported dead while hundreds of thousands were considered displaced. The chaos was followed by a long mediation process kicked off with the AU chairman, John Kufuor, president of Ghana, hosting a number of talks between the two parties. However, this did not bear much fruit as the two conflicting parties could not agree on the main issue of the creation of a position of Prime Minister for Raila Odinga to 7 fill. This was then followed by a more successful mediation process hosted by the Elders1 including former United Nations (UN) secretary general, Kofi Annan, Graça Maçhel and Benjamin Mkapa, as indicated by The Daily Nation newspapers throughout the month of January 2008. It is with this background that the study will now turn to the discussion about the context of the research, its objectives, rationale, motivation and the research design
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  • Date Issued: 2009
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