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Implementation of intravenous to oral antibiotic switch therapy guidelines in the general medical wards of a tertiary level hospital

  • Authors: Van Niekerk, Anida
  • Date: 2010
  • Subjects: Antibiotics -- Administration
  • Language: English
  • Type: Thesis , Masters , MPharm
  • Identifier: vital:10160 , http://hdl.handle.net/10948/1325 , http://hdl.handle.net/10948/d1012901 , Antibiotics -- Administration
  • Description: The overuse of antibiotics and consequent resistance is a common problem in medical practice worldwide. Switch therapy is a technique that can be applied to streamline antibiotic therapy reducing unnecessary prolonged Intravenous (IV) antibiotic therapy. Antibiotic switch therapy has several other benefits such as: decreasing length of hospital stay; decreasing the incidence of adverse events associated with the administration of IV antibiotics; decreasing direct and indirect hospitalisation costs while improving patients’ comfort and mobility; and decreasing the risk of acquiring nosocomial infections. Certain elements are required to make the implementation of any guideline, including a switch therapy guideline, a success and probably one of the most important is the support from a motivated multidisciplinary team. The role of such a team, in the South African context, would be filled by the Pharmacy and Therapeutics Committee (PTC). In addition, to make a guideline successful it should be continuously implemented. This responsibility traditionally falls to a pharmacist. In the United Kingdom (UK) and the United States of America (USA) pharmacists are used to promote the appropriate use of antibiotics in hospitals as this has shown to have several economic advantages. The objectives of the study were: to determine, by means of a survey, whether guidelines for IV to oral switch were employed in South African regional, tertiary and national government hospitals; to design and implement an IV to oral antibiotic switch therapy (IVOST) guideline for a local public sector tertiary level hospital; to evaluate the effectiveness of guideline implementation; and to capture, via a questionnaire, the perceptions of prescribers regarding antibiotic prescribing, including switch therapy. The Survey of Current IV Switch Therapy Practice Questionnaire was distributed to Responsible Pharmacists at regional, provincial tertiary and national central government hospitals to determine whether IVOST guidelines were employed in South African government hospitals. Following the survey, an IVOST Guideline was designed by the researcher in consultation with the Department of Medicine and the Department of Pharmacy. The IVOST Guideline was implemented following approval by the PTC at a local tertiary level government hospital. A presentation was held for prescribers, guideline documents were distributed, posters were placed in the medical wards and the ward pharmacist/researcher integrated the guideline into daily practice by placing “reminder stickers” in patient medical folders. A pre-implementation audit and two post-implementation audits, each consisting of 150 patient medical records, were conducted and compared to determine the effect of IVOST guideline implementation on prescribing patterns and to determine whether any changes could be sustained. The Prescriber Antibiotic Survey was then conducted to capture the perceptions of prescribers regarding antibiotic therapy, including switch therapy.
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  • Date Issued: 2010

Implementation of novel flow cytometric methods to assess the in vitro antidiabetic mechanism of a Sutherlandia Frutescens extract

  • Authors: Elliot, Gayle Pamela
  • Date: 2010
  • Subjects: Insulin resistance -- South Africa , Insulin -- Therapeutic use -- South Africa , Medicinal plants -- South Africa , Non-insulin-dependent diabetes -- South Africa
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:10304 , http://hdl.handle.net/10948/1439 , Insulin resistance -- South Africa , Insulin -- Therapeutic use -- South Africa , Medicinal plants -- South Africa , Non-insulin-dependent diabetes -- South Africa
  • Description: The ability of insulin to stimulate glucose uptake into muscle and adipose tissue is central to the maintenance of whole-body glucose homeostasis. Deregulation of insulin action manifests itself as insulin resistance, a key component of type 2 diabetes. Insulin resistance is also observed in HIV patients receiving protease inhibitors. An agent that can reversibly induce an insulin-resistant state would be a very useful tool in developing model systems that mimic the pathogenesis of type 2 diabetes. Insulin resistance can arise from defects in insulin signal transduction, changes in the expression of proteins or genes that are targets of insulin action, cross talk from other hormonal systems or metabolic abnormalities. Deterioration of the insulin-receptor-signalling pathway at different levels leading to decreased levels of signalling pathway intermediates and/or decreased activation through phosphorylation accounts for the evolution from an insulin-resistant state to type 2 diabetes. In addition, defects in GLUT4 glucose transporter translocation are observed, further fuelling impairments in skeletal muscle glucose uptake. Levels of insulin-induced GLUT4 translocation in the skeletal muscle of type 2 diabetic patients are typically reduced by 90%. Many cellular pathways & their intermediates are in some way or another linked to insulin signalling. This study focused on three of these namely the PI3-kinase/Akt pathway, the Mitogen Activated Protein Kinase (MAPK) cascade and the AMP Kinase pathway, with successful monitoring of the PI3-K pathway. Investigations involved observing and evaluating the effects of various compounds as well as an indigenous medicinal plant, Sutherlandia frutescens on the activities of key insulin signalling pathway intermediates within the three fore mentioned pathways including Akt, AMPK and MEK1/2 as well as membrane surface GLUT4 levels. Scientific research has in the past leant heavily on Western blotting as the method of choice for gaining vital information relating to signal transduction pathways, however for research into cellular mechanisms the negatives of this method outweigh the positives. The drawbacks include a need for large amount of cells, multiple washing steps which may be disadvantageous to any weak and transient interactions as well as lysing of cells which may interfere with the maintenance of the subcellular localisation of a specific signalling event. Based on these, the need for a better method in terms of speed & reliability to monitor phosphorylation states of signal transduction pathway intermediates & GLUT4 translocation was evident and was one VII of the main aims & successes of this study. The method created used the mouse muscle cell line C2C12 in conjunction with the quick, sensitive method of flow cytometry which allowed us to monitor these processes in these cells through immune-labelling. Adherent cell cultures such as the C2C12 cell line pose the problem of possible damage to plasma membrane receptors (including insulin receptors) during harvesting to obtain a cell suspension for flow cytometry. We however used C2C12 mouse myocytes to optimize a method yielding insulin responsive cells in suspension that were successfully used for flow cytometry after immunelabelling of insulin signalling intermediates. Insulin (0.1μM) significantly raised the levels of both P-Akt and GLUT4 above basal levels. This effect was shown to be dose dependent. At a concentration of 50μg/ml, Sutherlandia frutescens was able to act as an insulin-mimetic in terms of its ability to increase P-Akt levels, GLUT4 translocation and glucose utilisation in an acute manner. These increases could be reduced with the addition of wortmannin, a PI3-K inhibitor. Therefore, these results suggest the mechanism of the plant extract’s insulin-like activity may be in part due to the activation of the insulin signalling pathway leading to GLUT4 translocation, which involves the phosphorylation of insulin receptor- and subsequent PI3-K activity, leading to P-Akt activity. These results provide further evidence of this plant extract’s anti-diabetic potential. The effect of Sutherlandia frutescens on insulin secretion, calcium signalling and proliferation in INS-1 rat pancreatic cells was also investigated and it was found to increase the activities of all of these processes. However no change in the levels of GLUT2 glucose transporter was seen. Ritonavir is prescribed by the South African Department of Health in co-formulation with other protease inhibitors within its second regime in the treatment of HIV and AIDS. Using C2C12 cells, ritonavir decreased glucose uptake acutely and had no effect on GLUT4 translocation however surprisingly increased P-Akt levels. In conclusion, it was found that Sutherlandia frutescens has antidiabetic benefits, diverse in nature depending on tissue type as well as length of time administered. The establishment of novel flow cytometry techniques to assess antidiabetic properties using in vitro cell culture was achieved. These methods will be useful in the future for the assessment of insulin sensitivity and in the identification of novel compounds that stimulate the insulin signalling pathways.
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  • Date Issued: 2010

Implementation of the dual therapy prevention of mother-to-child transmission protocol

  • Authors: Singh, Vikesh
  • Date: 2010
  • Subjects: HIV infections -- Transmission -- South Africa , AIDS (Disease) in pregnancy -- Prevention -- South Africa , Antiretroviral agents
  • Language: English
  • Type: Thesis , Masters , MPharm
  • Identifier: vital:10138 , http://hdl.handle.net/10948/1374 , HIV infections -- Transmission -- South Africa , AIDS (Disease) in pregnancy -- Prevention -- South Africa , Antiretroviral agents
  • Description: Antiretroviral drugs taken during pregnancy, reduce the rates of mother-to-child transmission from 35 percent to as low as 1 to 2 percent (UNAIDS, 2009). In 2002, the Prevention of Mother-to-Child Transmission (PMTCT) programme was implemented in South Africa. Studies on the implementation of the PMTCT programme have shown that understaffed and under-developed health care facilities were key barriers to the provision of PMTCT services (Health Systems Trust, 2002: 6; Skinner et al., 2003). The aim of this study was to assess the challenges experienced by health care workers working in public sector facilities in the Nelson Mandela Metropole after implementation of the dual therapy PMTCT programme. Four areas were investigated: Infrastructure; Drug Supply Management; Clinic Procedures and Staffing. A quantitative descriptive study was conducted in August 2009 at nine public health care facilities in the Nelson Mandela Metropole, South Africa. Questionnaires were issued to 81 nurses and 41 pharmacy personnel (pharmacists and pharmacist assistants). Checklist audit forms were issued to the Facility Manager of each facility and completed with the researcher. The key findings for Infrastructure were lack of space at patient waiting rooms (9; 100 percent n=9), counselling area (5; 55.5 percent; n=9), nurse consultation rooms (6; 66.6 percent; n=9), storage areas (5; 55.5 percent; n=9) and filing areas (7; 77.7 percent; n=9). The key findings for Drug Supply Management were none of the dispensaries (0 percent; n=10) were fully compliant with Good Pharmacy Practice, pharmacy personnel indicated that there were no stock cards for medication (13; 31.7 percent; n=41); there was less than two weeks supply of buffer stock kept for zidovudine and nevirapine (13; 35.1percent; n=37) and medication orders were placed without any reference to minimum and maximum levels of medication (15; 36.5 percent; n=41) . The key findings for Clinic Procedures were only two facilities followed up on patients that had missed appointments (22.2 percent; n=9) and four facilities (44.4 percent; n=9) had a tracking system for patients that had defaulted. Of the nine facilities only three (33.3 percent; n=9) updated patient demographic details regularly. The key findings for Staffing were a shortage of doctors, nurses, counsellors and pharmacists at the facilities. One of the major challenges identified was the lack of training offered on new PMTCT protocols with 56.2 percent (45; n=80) of the nurses stating that no training was provided on the dual PMTCT protocol. Only 54.3 percent (44; n=81) of nurses stated that they knew the criteria to start the mother on dual PMTCT therapy. In conclusion there is an urgent need for barriers such as lack of staff, lack of space, lack of training on PMTCT and standard procedures for follow up of patients to be addressed in order to ensure the successful scaling up of PMTCT.
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  • Date Issued: 2010

Implementing capital budgeting for the multinational corporation

  • Authors: Wang, Xin
  • Date: 2010
  • Subjects: International business enterprises -- Accounting
  • Language: English
  • Type: Thesis , Masters , MTech
  • Identifier: vital:8939 , http://hdl.handle.net/10948/1304 , International business enterprises -- Accounting
  • Description: There are many reasons to believe that budgeting lies at the heart of business management. Gray et al (2001:324) states that ―budgetary planning and control is the most visible use of accounting information in the management control process. By setting standards of performance and providing feedback by means of variance reports, the accountant supplies much of the fundamental information required for overall planning and control. However, Gray et al (2001:324) point out that capital budgeting decision is limited by the intricacies of the international business environment, which is characterized by economic, social, political, and cultural diversity. Therefore, decisions of capital investments and budgetary controls are more problematic (Gray et al., 2001:14). One of the defining characteristics of the globalization of the world economy in the past two decades has been the spread of multinational corporations' activities across countries, and, as a result, significant increases in global foreign direct investment (FDI) outflow in the 1990s (from R233 billion in 1990 to R1, 379 billion in 2000). For example, the total stock of Chinese direct investment abroad nearly tripled over the 1990s (from $2.2 trillion in 1990 to $6.3 trillion in 2000) as Chinese multinational corporations generated an increasingly large share of world GDP (6.8 percent in 1994 and 8.6 percent in 2000). Multinational corporations have become an important conduit in the global allocation of investment funds. However, the business environment in international markets has been considered volatile; there is no reliable and accurate method to aid 2 multinational corporations about decisions about the international environment. Thus, multinational corporations have encountered risk and challenge. Given the development and challenge of the international environment, this study have been considered to plan over a longer time horizon, develop formal mechanisms to set aside funds for preserving existing facilities, increase automation of the process, and link capital planning decisions to statewide performance goals and strategic plans. This research draws upon existing theoretical determinants of capital budgeting and empirically tests the hypotheses across a sample of multinational corporations in China. Although the sample is from China, the results have important implications for multinational corporations based in other countries. This paper is composed of four parts. The first part briefly gives both a theoretical and practical overview of multinational capital budgeting analysis. The second part discusses the data collection techniques and the questionnaire design used in this study. The third part provides some important findings of this research. The last section offers some conclusions from this study.
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  • Date Issued: 2010

Implications of a currency board arrangement for the Zimbabwean economy: the lessons of experience

  • Authors: Ndlovu, Edwin
  • Date: 2010
  • Subjects: Economic indicators , Inflation targeting , Foreign exchange
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10353/26492 , vital:65480
  • Description: Inflation is one of the most important factors for gauging the health of the economy. For production, employment and trade to take place, it is crucial that inflation be low and stable. This study analyses the implications of a currency board system in a hyperinflationary economy, using quarterly Zimbabwean data covering the period 1995 to 2008.An empirical model linking inflation to its identified theoretical determinants is specified. The study employs a cointegration and a vector error correction (VEC) modeling, to provide robust long run and short run dynamic effects of hyper inflation on the economy. The empirical findings reveal a strong significant relationship between inflation and government deficit, expected inflation, money supply growth and the exchange rate. These results corroborate the theoretical predictions and the previous findings that most hyperinflations are deficit-induced. The study thus suggests an implementation of a currency board arrangement for Zimbabwe to eradicate hyperinflation based on its link with exchange rate, money supply and government deficit. A currency board restrains the tendency by most central banks to create money to finance government deficits, and reduces expectations of rising inflation through its instantaneous credibility in reducing inflation. , Thesis (MCom) -- Faculty of Management and Commerce, 2010
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  • Date Issued: 2010

Improving customer service through effective supply chain management in a pharmaceutical company

  • Authors: Rothner, Donne
  • Date: 2010
  • Subjects: Customer services -- South Africa , Customer services -- Management , Customer services -- South Africa -- Quality control , Business logistics -- South Africa
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: vital:8625 , http://hdl.handle.net/10948/1490 , Customer services -- South Africa , Customer services -- Management , Customer services -- South Africa -- Quality control , Business logistics -- South Africa
  • Description: All organisations compete on the basis of service. In today‘s highly competitive world, organisations need to compete to retain their customers and to offer good customer service that will give them a competitive advantage. In the South African pharmaceutical market, the introduction of the Single Exit Price (SEP) and generic substitution have led to the price of equivalent medicines no longer being the differentiating factor in a customer deciding which manufacturer‘s product to purchase. The availability of generic medicines at the pharmacy or hospital has become the differentiating factor. Two types of customers exist in any organisation, namely, external customers and internal customers. Much has been written about the external customer, but less about the internal customer. Many managers do not perceive internal customer service as a priority. Any organisation attempting to deliver quality service to their external customers must begin by serving the needs of their internal customers. Internal service quality is characterised by the attitudes that people have towards one another and in the way that employees serve one another inside the organisation. By improving customer service, the organisation can improve its profitability, sustainability and customer retention. The aim of this study was to determine whether the levels of internal customer service between the three sections of Aspen Pharmacare are optimal. Determining the current performance levels between the staff of the sections will assist in highlighting the areas that require attention. The three sections of Aspen Pharmacare that are internal customers of one another and have been used in the study are: - production; - demand planning; and - distribution. The results of the study show that all three sections rate three service quality dimensions (communication, tangibles and reliability) as important. The results were used to develop an internal customer service model for Aspen Pharmacare.
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  • Date Issued: 2010

Improving economic development through effective communication strategies in Nelson Mandela Bay

  • Authors: Headbush, Shambalda
  • Date: 2010
  • Subjects: Communication in economic development
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: vital:8666 , http://hdl.handle.net/10948/1246 , Communication in economic development
  • Description: The purpose of this study is to improve Local Economic Development (LED) through effective communication strategies between Local Government and the Private sector in Nelson Mandela Bay. The study has been carried out by means of a literature and a primary study. Effective communication is one of the key elements which contribute to the success of Local Economic Development implementation. The communication strategies in Local Economic Development have been discussed and analysed to determine the ineffective methods of communication in Local Economic Development implementation. The literature indicated that a good communication strategy is determining the most effective method of communicating with ones’ target audience. The findings of the primary study revealed that the communication strategy between the stakeholders was not fully maximised in improving Local Economic Development implementation. It also revealed secondary factors that contributed to the ineffectiveness of Local Economic Development implementation. In order to improve the current communication strategies, the researcher recommended that new forms of communication medium between Government and the Private sector could be introduced. Lastly, the secondary factors which contribute to ineffective Local Economic Development implementation were analysed and recommendations were suggested.
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  • Date Issued: 2010

Improving explanation writing skills of junior secondary learners in life sciences: a case study

  • Authors: Josua, Helena Megameno N
  • Date: 2010
  • Subjects: Writing skills English language -- Study and teaching (Secondary) -- South Africa English language -- Writing -- Study and teaching
  • Language: English
  • Type: Thesis , Masters , MEd
  • Identifier: vital:1570 , http://hdl.handle.net/10962/d1003452
  • Description: Learners in the Junior Secondary Phase (Grades 8 to 10) are often required to answer open-ended questions which require a response in the form of an explanation. As frequently reported in the external examiners' reports of Life Sciences, learners do not write adequate explanations as responses to explanatory questions. This thesis reports on action research based on my experience as a Life Sciences teacher trying to address this problem. Therefore, the purpose of this study was to develop suitable, manageable and effective strategies that I could implement in order to improve my teaching of explanation writing skills of in the Junior Secondary school learners with a view to enhance curriculum content knowledge in Life Sciences. The intervention was carried out in a Grade 10 Life Sciences class which consisted of 35 learners. The first cycle consisted of seven lessons carried out over two weeks in normal school time. The main sources of data from my lesson interventions were the learners' written work, their journal entries, the researcher's journal, the field notes from the non-participant observer and interviews with two focus groups. Both the interviews and the lessons were recorded and transcribed. The research data reveals that the ability of the Junior Secondary learners to write explanations was hindered by language problems. In addition, a lack of integration of language issues into the subject content was a contributing factor to their inadequate writing skills. Spelling errors and lack of expression in English second language contribute to the problem of writing good explanations. The data has also revealed that learners‟ writing skills can be improved by implementing suitable teaching strategies, such as the curriculum cycle as proposed by Gibbons (2002). The curriculum cycle can be modified to fit the learners' needs and the real teaching situation. The amount of practice required to master the skill of writing in the genre of explanations should be considered.
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  • Date Issued: 2010

Improving Productivity of Maize-based Smallholder Irrigated Cropping Systems: A Case Study of Zanyokwe Irrigation Scheme, Eastern Cape, South Africa

  • Authors: Fanadzo, Morris
  • Date: 2010
  • Subjects: Farms, Small -- South Africa -- Eastern Cape Crop yields -- South Africa -- Eastern Cape Agricultural productivity -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: http://hdl.handle.net/10353/11009 , vital:36450
  • Description: Smallholder irrigation schemes (SIS) in South Africa have performed poorly and failed to achieve the development objectives of sustaining rural livelihoods by increasing crop production and income. Limited knowledge of crop production among farmers is one constraint to improved crop productivity and, yet little research has been carried out to relate agronomic practices to productivity. This study was aimed at identifying strategies to improve the productivity of maize-based smallholder irrigated cropping systems in South Africa, using Zanyokwe irrigation scheme (ZIS) in the Eastern Cape Province as a case study. The research design was emergent, developed progressively as influenced by the progressive analyses that were made. The research work involved two main phases: exploratory studies and refinement on-farm experiments for testing technologies as informed by the exploratory studies. Exploratory studies were aimed at describing farmer crop production practices in major crop enterprises and identifying and prioritizing major agronomic yield constraints. Findings indicated that the overall performance of the cropping systems was poor as evidenced by low overall yields of < 25% of the potential in maize and butternut. Poor management of weeds, soil fertility, plant populations and water, late planting and poor cultivar choice were the most important yield constraints. The average cropping intensity achieved by farmers was only 48%. New hybrids yielded 50 - 65% higher grain than the cultivars commonly grown by farmers. However, farmers favoured their traditional cultivars, as they preferred green maize production as opposed to dry grains. As a result of these findings, focused research was designed on options for iii improving green maize production, soil fertility, crop stand and weed management in crop production. On-farm trials were, therefore, designed to (1) compare the response to nitrogen (N) rate of direct seeded and transplanted maize; (2) evaluate comparative performance of direct seeded and transplanted green maize under farmer management, and to work out the economics of transplanting; (3) investigate the effects of row spacing and atrazine dosage on weed dynamics maize yield; (4) determine the effects of inter-row spacing and plant population on weed dynamics and maize yield; and (5) investigate the effects of pre-plant weed control, N rate and plant population on weed dynamics and butternut yield. Maize transplanting improved crop stand, had earlier maturity and yielded higher at lower N rates compared to direct seeding for both green and grain maize. Total costs that varied were higher by R3 565 ha-1 for transplanted maize compared to direct-seeded maize, but the net benefits from transplanting were also much higher by R8 773 ha-1. Farmers favoured transplanting, citing bigger cobs, early maturity and the absence of seedling damage by birds, when maize was transplanted. However, a follow-up survey conducted during the subsequent year indicated that five of the six farmers abandoned transplanting, citing shortage of labour and high cost of commercially produced seedlings. It was concluded that transplanting is unlikely to be adopted unless the labour intensiveness of manual transplanting can be solved. Increasing atrazine dosage from a third of the label recommended dosage (LRD) and reducing row spacing from 90 to 45 cm resulted in an increase in weed mortality. A 100% kill of annual broadleaf weeds was possible while iv perennial grasses and the annual broadleaf weed, Oxalis latifolia, could not be controlled even at the LRD. However, improved weed mortality with increase in atrazine dosage and/or narrow rows did not translate into improved maize productivity. In butternut, pre-plant weed control resulted in a six-fold decrease in weed biomass and a 100% increase in fruit yield. These findings demonstrated the possibility of incorporation of reduced herbicide dosages and narrow rows to achieve adequate weed control and optimise on maize yields in smallholder farming systems. The results also suggested that pre-plant weed control is one of the pre-requisite to successful butternut production in SIS in South Africa. Increasing maize population from 40 000 to 60 000 plants ha-1 resulted in a 30% grain yield increase, but decreased length of cobs. Row spacing had no effect on maize yield at 40 000 plants ha-1, but at 60 000 plants ha-1 45 cm rows resulted in 11% higher grain yield (12 547 kg ha-1) than 90 cm rows (11 288 kg ha-1). Butternut yield increased significantly (p < 0.01) with increase in plant population and N rate. The optimum butternut population and N rate were estimated at 25 000 plants ha-1 and 120 kg N ha-1, respectively. Pre-plant weed control in butternut resulted in a six-fold decrease in weed biomass. Increasing butternut planting density from 10 000 to 30 000 plants ha-1 decreased weed biomass by 47%. No marketable fruits were obtained when planting was done without prior weed control. This result suggest that application of non-selective herbicide before planting is one technique that can be used by farmers as part of integrated weed management to give the crop a competitive advantage in the early growth stages before the plants start to produce vines. Yield increased significantly (p < 0.01) with increase in plant density and N rate. The optimum plant density and N rate were estimated at 25 000 plants ha-1 and 120 kg N ha-1, respectively. These findings emphasise the need to take into consideration production practices by farmers as a basis to build up skills in the management of crop enterprises and the farm as a viable business in any efforts to improve on the performance of SIS in South Africa. Future research should concentrate on labour-saving sustainable production technologies for SIS in South Africa.
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  • Date Issued: 2010

Improving project implementation in firms

  • Authors: Hassen, Ismail
  • Date: 2010
  • Subjects: Project management -- South Africa
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: vital:8667 , http://hdl.handle.net/10948/1245 , Project management -- South Africa
  • Description: Project implementation appears to be one the most difficult aspects of a manager’s job. The purpose of project management is to forecast or anticipate potential dangers and problems that may jeopardise the success of a project and then to plan, organise and control activities that will lead to the successful completion of projects in spite of all the envisaged risks. It is estimated that more than 80% of projects run late or over budget. Such failure often sinks small firms and erodes profits of larger organisations. Project implementation is therefore critical to the success of both small and big firms. The primary objective of this study is to improve project management in firms by investigating the variables that influence project implementation. More specifically, the study investigates the influence of organisational communication, leadership, business process management and resistance to change on project implementation. The sample consisted of 170 employees in a cross-section of industries. The sample was stratified to include senior managers, managers, supervisors and lower level employees. The empirical results show that organisational communication, participatory leadership, retention of the status quo and goal-oriented leadership increase project implementation, while resistance to change decreases project implementation.
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  • Date Issued: 2010

Improving sanitization and fertiliser value of dairy manure and waste paper mixtures enriched with rock phosphate through combined thermophilic composting and vermicomposting

  • Authors: Mupondi, Lushian Tapiwa
  • Date: 2010
  • Subjects: Compost , Vermicomposting , Manures , Biodegradation , Waste paper -- South Africa -- Eastern Cape , Thermophilic bacteria , Fertilizers
  • Language: English
  • Type: Thesis , Doctoral , PhD (Soil Science)
  • Identifier: vital:11961 , http://hdl.handle.net/10353/411 , Compost , Vermicomposting , Manures , Biodegradation , Waste paper -- South Africa -- Eastern Cape , Thermophilic bacteria , Fertilizers
  • Description: Thermophilic composting (TC) and vermicomposting (V) are the two most common methods used for biological stabilization of solid organic wastes. Both have their advantages and disadvantages but the proposed method of combining composting and vermicomposting (CV) borrows pertinent attributes from each of the two methods and combines them to enhance overall process and product qualities. Dairy manure and waste paper are two wastes produced in large quantities at the University of Fort Hare. The study was carried out to address the following specific objectives, to determine (i) the effectiveness of combined thermophilic composting and vermicomposting on the biodegradation and sanitization of mixtures of dairy manure and paper waste, (ii) an optimum precomposting period for dairy manure paper waste mixtures that results in vermicomposts of good nutritional quality and whose use will not jeopardize human health, (iii) the effectiveness of phosphate rock (PR) in increasing available P and degradation and nutrient content of dairy manure-paper vermicomposts, (iv) the physicochemical properties of vermicompost substituted pine bark compost and performance of resultant growing medium on plant growth and nutrient uptake. Results of this study revealed that wastes with a C: N ratio of 30 were more suitable for both V and CV as their composts were more stabilized and with higher nutrient contents than composts made from wastes with a C: N ratio of 45. Both V and CV were effective methods for the biodegradation of dairy manure and paper waste mixtures with C: N ratio of 30 but the latter was more effective in the biodegradation of waste mixtures with a C: N ratio of 45. The combinination of composting and vermicomposting eliminated the indicator pathogen E. coli 0157 from the final composts whereas V only managed to reduce the pathogen population. iv A follow up study was done to determine the effects of precomposting on pathogen numbers so as to come up with a suitable precomposting period to use when combine composting dairy manure-waste paper mixtures. Results of this study showed that over 95% of fecal coliforms, E. coli and of E. coli 0157 were eliminated from the wastes within one week of precomposting and total elimination of these and protozoan (oo)cysts achieved after 3 weeks of precomposting. The vermicomposts pathogen content was related to the waste’s precomposting period. Final vermicomposts pathogen content was reduced and varied according to precomposting period. Vermicomposts from wastes precomposted for over two weeks were less stabilized, less humified and had less nutrient contents compared to vermicomposts from wastes that were precomposted for one week or less. The findings suggest that a precomposting period of one week is ideal for the effective vermicomposting of dairy manure-waste paper mixtures. Results of the P enrichment study indicated an increase in the inorganic phosphate and a reduction in the organic phosphate fractions of dairy manure-waste paper vermicompost that were enriched with PR. This implied an increase in mineralization of organic matter and or solubilization of PR with vermicomposting time. Applying PR to dairy manure-waste paper mixtures also enhanced degradation and had increased N and P contents of dairy manure-waste paper vermicomposts. Earthworms accumulated heavy metals in their bodies and reduced heavy metal contents of vermicomposts. A study to determine the physicochemical properties of vermicompost substituted pine bark compost and performance of resultant growing medium on plant growth and nutrient uptake was done. Results obtained revealed that increasing proportions of dairy manure vermicomposts in pine bark compost improved tomato plant height, stem girth, shoot and root dry weights. v Tomatoes grew best in the 40 to 60% CV substituted pine bark and application of Horticote (7:2:1 (22)) fertilizer significantly increased plant growth in all media. Progressive substitution pine bark with dairy manure vermicomposts resulted in a decrease in the percentage total porosity, percentage air space whilst bulk density, water holding capacity, particle density, pH, electrical conductivity and N and P levels increased. Precomposting wastes not only reduced and or eliminated pathogens but also improved the stabilisation and nutrient content of dairy manure waste paper mixtures. The application of PR to dairy manure waste paper mixtures improved the chemical and physical properties of vermicomposts. Earthworms bio-accumulated the heavy metals Cd, Cr, Cu, Pb and Zn whilst the contents of these in the vermicomposts declined. It is, therefore, recommended that dairy manure waste paper mixtures be precomposted for one week for sanitization followed by PR application and vermicomposting for stabilization and improved nutrients contents of resultant vermicomposts. Substitution of pine bark compost with 40 to 60 % PR-enriched vermicompost produced a growing medium with superior physical and chemical properties which supported good seedling growth. However, for optimum seedling growth, supplementation with mineral fertilizer was found to be necessary.
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  • Date Issued: 2010

Improving the sales success at Avusa Publishing Eastern Cape

  • Authors: Gerwel, Ettienne
  • Date: 2010
  • Subjects: Sales management -- South Africa , Advertising, Newspaper -- South Africa , Selling
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: vital:8634 , http://hdl.handle.net/10948/1453 , Sales management -- South Africa , Advertising, Newspaper -- South Africa , Selling
  • Description: Avusa Publishing (East Cape) (APEC) publishes several of the oldest and best known newspaper products in the Eastern Cape. The Eastern Province Herald is currently the oldest daily morning newspaper in South Africa and the average daily circulation of the paper is 25 000. Its main distribution is in the Nelson Mandela Bay Metropolitan area, as well as the area up to the Garden Route and as far East as Port Alfred. APEC also publishes the Weekend Post. According to the financial statements and circulation and advertisement figures of the company, the revenue generated by the company has not increased, but stayed stagnant. In addition to this, the daily circulation of the flagship publication, The Herald, has decreased from 29 000 in 2005 to 24 000 in 2008. As the company only generates revenue from two sources, namely advertising sales and the sale of newspapers, the above mentioned situation negatively affects the financial wellbeing of the company. The management dilemma that needed to be researched was how APEC's circulation and advertising income could be increased. The primary objective of this study was therefore to improve APEC's sales success by investigating the determinants of such sales success. More specifically, the study investigated the influence of determinants such as newsworthiness, value proposition, brand awareness, customer service, customer loyalty, credibility and new media on sales success, as measured by increased circulation and advertising revenue. Convenience sampling was used to select 287 employees working for the company. A mail survey was conducted among these 287 employees, but only 114 usable questionnaires were returned (a response rate of 40 percent). The empirical results revealed that brand awareness, customer loyalty and the use of new media technologies exerted a significantly positive influence on the sales success of APEC. The results further showed that newsworthiness, editorial credibility, value proposition and customer service exerted no significant influence on the APEC’s sales success. Despite the latter findings, the results revealed that there was a high level of trust and loyalty in the editorial content of APEC, as well as the perception of good value for money among both readers and advertisers. The managerial implications of these findings are discussed and areas of future research are recommended.
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  • Date Issued: 2010

In search of critical engagement: a history of South African university based journalism

  • Authors: Du Toit, Jeanne E , De Beer, Arnold S
  • Date: 2010
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/159453 , vital:40299 , https://hdl.handle.net/10520/EJC139372
  • Description: Historical discussions of South African journalism education (Tomaselli 1991: 167; De Beer and Tomaselli 2000; Steenveld 2006) refer to examples of teaching practice which have served as critical interventions into political process. They occur primarily in the late 1970s and 1980s and it is arguable that the social circumstances that existed during this period presented unique opportunities for critical education. The literature suggests, however, that these examples represent the exception rather than the rule. It would seem, in fact, that a critical approach to journalism education has never been realised in South Africa in any substantive way. It is with this argument in mind that I explore, in this paper, the historical construction of journalism as a subject of university education in South Africa.
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  • Date Issued: 2010

In vitro bioactivity of crude extracts of Lippia javanica on clinical isolates of Helicobacter pylori: preliminary phytochemical screening

  • Authors: Nkomo, Lindelwa Precious
  • Date: 2010
  • Subjects: Extracts , Helicobacter pylori , Antibiotics , Drug resistance in microorganisms , Materia medica, Vegetable
  • Language: English
  • Type: Thesis , Masters , MSc (Microbiology)
  • Identifier: vital:11257 , http://hdl.handle.net/10353/508 , Extracts , Helicobacter pylori , Antibiotics , Drug resistance in microorganisms , Materia medica, Vegetable
  • Description: Helicobacter pylori classified as a class 1 carcinogen is a common human pathogen implicated in certain gastrointestinal diseases. Helicobacter pylori infection is acquired mainly in childhood, especially in developing countries. H. pylori infection causes peptic ulcer, duodenitis, gastritis and cancer. The growing resistance of H. pylori to antibiotics used in its treatment as well as other innate limitations of the triple therapy has necessitated a search for alternative treatment from natural sources which could be readily available, less cost effective. The antimicrobial activity of solvents (acetone, ethanol, methanol, chloroform and water) crude extracts of Lippia javanica were investigated against 31 H. pylori strains by the agar well diffusion technique. The minimum inhibitory concentration (MIC) was determined by spectrophotometric analysis at 620 nm using the broth micro dilution method and the rate of kill by broth dilution method. Phytochemical analysis was also performed. H. pylori standard strain NCTC 11638 was included as a positive control. Metronidazole and amoxicillin were used as positive control antibiotics. The ANOVA test was used to analyze the results using SPSS version 17.0. The strains were inhibited by all the extracts with inhibition zones of diameter ranging from 0-36 mm and 0-35 mm for the control antibiotic, clarithromycin. The MIC90 ranged from 0.039- 0.625 mg/mL for acetone; 0.039-1.25mg/mL for methanol, 0.00195-0.313 mg/mL for ethanol; 0.01975-2.5 mg/mL for metronidazole and 0.0048-2.5 mg/mL for amoxicillin. Acetone extract completely inhibited strain PE369C at MIC (0.1 mg/mL) and 2× MIC (0.2 mg/mL) in 18h and at ½× MIC (0.05 mg/mL) in 36h. Strain PE466C was completely inhibited at 4× MIC in 72h. Phytochemical analysis revealed the presence of flavonoids, saponins, tannins, steroids and alkaloids. The results indicate that the extracts of the leaves of L. javanica may contain compounds with anti-H. pylori activity and merits further study to identify the compounds.
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  • Date Issued: 2010

In-service training for academic librarians : a pilot programme for staff

  • Authors: Shepherd, Eileen
  • Date: 2010
  • Language: English
  • Type: Article
  • Identifier: vital:6992 , http://hdl.handle.net/10962/d1012418 , http://www.emeraldinsight.com/doi/full/10.1108/02640471011065346
  • Description: This paper discusses the need for continuing professional development for librarians in academic libraries in general and at Rhodes University Library, South Africa in particular. It describes the planning, design, implementation and evaluation of a staff-development and training pilot programme for professional librarians at Rhodes Library. A group of 15 librarians, drawn from the library staff complement, participated in an 8-session training course developed by Information Services librarians. The course, which covered basic information-finding skills using a variety of research databases and offered an introduction to concepts in 21st century academic librarianship, was presented using course management software in a face-to-face environment and required homework exercises and the completion of a 2-hour final test. The results of the project demonstrated the urgent need for such development programmes for professional library staff. 80% of the participants completed the course. The final test results indicated below average database search skills and an inability to think laterally. An unexpected finding was a lack of IT competencies. Important lessons were learned with regard to course-construction, content and timing.
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  • Date Issued: 2010

Indicators of sustainable fishing for South African sardine Sardinops sagax and anchovy Engraulis encrasicolus

  • Authors: Fairweather, T P , Van der Lingen, C D , Booth, Anthony J , Drapeau, L , Van Der Westhuizen, J J
  • Date: 2010
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/124778 , vital:35691 , https://doi.10.2989/18142320609504215
  • Description: Six indicators were investigated for South African sardine Sardinops sagax and anchovy Engraulis encrasicolus: mean length of catch, length-at-50% maturity, total mortality, exploitation rate, ratio of bycatch, and centre of gravity of commercial catches. Sardine length-at-50% maturity is the most promising as a descriptive indicator because it is positively correlated with population size for an extensive time period (1953–2005). The remaining indicators were limited by shorter data-series (1984–2005). However, mean length of catch, ratio of bycatch and exploitation rate were found to be useful when considered in conjunction with other indicators. The centre of gravity of commercial sardine catches has shown a significant eastward shift from the West Coast, whereas that of anchovy has remained off that coast. Ratio of bycatch indicates that school composition is a reliable descriptive indicator of relative abundance in the two species. Fewer indicators for anchovy were useful, which is attributed to this species’ flexible life-history pattern.
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  • Date Issued: 2010

Indigenous technology and culture in the technology curriculum : starting the conversation : a case study

  • Authors: Vandeleur, Sonja
  • Date: 2010
  • Subjects: Curriculum evaluation -- South Africa Curriculum planning -- South Africa Education -- Curricula -- South Africa Technology -- Study and teaching -- South Africa Indigenous peoples -- Education -- South Africa
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:1573 , http://hdl.handle.net/10962/d1003455
  • Description: Since the collapse of apartheid and the first democratic elections of 1994, education in South Africa has undergone fundamental transformation and part of this transformation was the reconstruction of the school curriculum. The new curriculum, known as Curriculum 2005 and developed in 1997, introduced Technology as a new learning area. This study is based on the inclusion of ‘indigenous technology and culture’, a new aspect introduced in a revision of Curriculum 2005. The broad goal of the study was to examine and explore pedagogic practice in relation to the inclusion of ‘indigenous technology and culture’ in the revised National Curriculum Statement for Technology. The study was informed by an examination of literature pertaining to philosophy of technology, indigenous knowledge systems and technology education. The review of the literature highlighted the contested nature of ‘indigenous knowledge systems’. Philosophies on the nature of technological knowledge were reviewed in order to explore the meaning of ‘technology’, and a comparative review of curriculum reform in regard to technology education in various parts of the world was conducted. This study presented an attempt to determine the rationale for the inclusion of ‘indigenous technology and culture’ in the revised National Curriculum Statement for Technology in South Africa and to explore and examine what teachers’ existing practices were in this regard. It also examined a process of participatory co-engagement with a focus group of teachers. This process was an attempt to implement ‘indigenous technology and culture’ of the curriculum in a more meaningful way. A case study approach using an in-depth, interpretive design was used. A questionnaire, document analysis, interviews and focus group discussions were used to conduct the investigation. What emerged from the data analysis was that there was unanimous support for the inclusion of ‘indigenous technology and culture’ in the technology curriculum, but implementation had been problematic. This was partly due to difficulties with the interpretation of this aspect in the curriculum as well as a lack of meaningful teaching and learning for various reasons. The study revealed that teachers face multiple dilemmas in implementing ‘indigenous technology and culture’ as an assessment standard. These dilemmas are pedagogical, political, conceptual, professional and cultural in nature. The intentions of the study were to build a comprehensive understanding of ‘indigenous technology and culture’ and to determine how a focus group of teachers were dealing with this new inclusion. The interpretive study concluded with implications and recommendations for further studies.
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  • Date Issued: 2010

Induced plant responses of different Lantana camara L. (Verbenaceae) varieties to herbivory by Falconia intermedia (distant) (Hemiptera: Miridae)

  • Authors: Heshula, Unathi-Nkosi Lelethu Peter
  • Date: 2010
  • Subjects: Lantana camara -- South Africa -- Eastern Cape , Lantana camara -- Biological control -- South Africa -- Eastern Cape , Biological pest control agents -- South Africa -- Eastern Cape , Weeds -- Biological control -- South Africa -- Eastern Cape , Invasive plants -- Biological control -- South Africa -- Eastern Cape , Hemiptera -- South Africa -- Eastern Cape , Miridae -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:5911 , http://hdl.handle.net/10962/d1015368
  • Description: A highly variable invasive shrub, Lantana camara L. (Verbenaceae), has been notoriously difficult to control thus far despite a well established biological control programme in South Africa. A promising leaf-feeding biological control agent, Falconia intermedia (Distant) (Hemiptera: Miridae), released to control this invasive plant eventually crashed at three out of five sites in the Eastern Cape Province. In the Mpumalanga Province, after initially colonising and building up high numbers on the L. camara stands the agent populations crashed. Several reasons for these population crashes have been suggested, but induced plant defences have not been investigated. Although plants face the challenge of herbivory by various organisms while remaining immobile, some plants may possess the ability to induce physical and/or chemical defensive responses following feeding and thus prevent further plant tissue damage and loss. Laboratory trials were conducted to determine the existence, nature and effect of physical and chemical feeding-induced responses of L. camara on the performance of the leaf-feeding biological control agent, F. intermedia. Lantana camara plants used in the study were obtained from five localities in the Eastern Cape Province, South Africa, while the insect culture was established from field populations. Plants from all varieties on which F. intermedia was released significantly increased the toughness of their leaves compared to control treatment plants. In addition, plants from three localities: Lyndhurst Farm, East London and Port Alfred, significantly increased trichome density after prolonged feeding by F. intermedia. On the three varieties showing increases in these two factors (i.e. leaf toughness and trichome density), oviposition, survival and feeding damage by the mirid agent was significantly lower on previously damaged plants. A significant negative correlation between trichome density and population numbers was found (R²= 0.52, p < 0.0003), suggesting that an increase in trichome density strongly contributes to a reduction in F. intermedia's growth. The growth and reproduction of the resistant plants was not significantly impacted by F. intermedia feeding. The defensive responses were found to be plant systemic and rapidly induced as they were elicited and expressed throughout the plant in both damaged and undamaged leaves within five weeks after insect release. Leaf toughness and trichome density were not significantly increased after feeding on plants from Whitney Farm and Heather Glen Farm. On the contrary, mirid individuals performed significantly better on plants from Whitney Farm and Heather Glen Farm than on plants of other varieties, indicating their susceptibility and suitability to the agent and the lack of induced resistance against the agent. Plants from all localities besides East London showed some level of tolerance and overcompensated for feeding damage by increasing plant growth and reproductive factors on plants fed upon. This was however only significant in two variables of the more susceptible localities, Whitney Farm and Heather Glen Farm. This increase in plant fitness did however indicate an induced defence response by these plants to feeding, a response designed to lessen the effects of agent feeding. Headspace volatile analysis was used to investigate any volatile chemical responses by L. camara due to F. intermedia feeding at two of the five localities chosen: East London and Whitney Farm. There was no significant difference in headspace volatiles emitted by leaves of plants from the East London insect infested and control treatment plants. On the Whitney Farm damaged plants however there was a 2.5 fold increase in the emission intensity of one of the three main compounds, later identified as Beta-caryophyllene. Three major chemical constituents which were found to be common to leaf volatiles of the two varieties were identified through gas chromatography-mass spectrometry (GC-MS) from the damaged and undamaged leaves of these two varieties. The methods used in collecting leaf volatiles were shown to be significant in the strength of chromatogram peaks. Using general authentication methods and purified standards, one of these was identified as the sesquiterpene, Beta-caryophyllene (C₁₅H₂₄). This compound is one of the major constituents found in isolations of L. camara varieties worldwide. This is the first such work done on a variety of L. camara in South Africa, and hopefully the beginning of more in-depth studies of the volatile organic chemicals from the numerous naturalised varieties of L. camara. It is suggested that the sum of these responses may play a role bigger than is currently understood in this plant-insect relationship. It is also argued that feeding induced plant defences may play an important role in attempts to control alien plants using insect agents.
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  • Date Issued: 2010

Influence of institutional factors on smallholder farmers’ marketing channel choices

  • Authors: Jari, Bridget , Fraser, Gavin C G , Obi, A
  • Date: 2010
  • Subjects: To be catalogued
  • Language: English
  • Type: text , book
  • Identifier: http://hdl.handle.net/10962/473010 , vital:77598 , ISBN 978-90-8686-132-3 , https://brill.com/edcollbook/title/68924
  • Description: Smallholder farmers are faced with a range of institutional challenges in produce marketing. In turn, these challenges influence their selection of marketing channels. In this chapter, a multinomial logistic regression model was used to test the significance of institutional factors in marketing. The results are based on a case study for smallholder farmers in the Kat River Valley, in South Africa. It is shown that the statistically significant variables are access to market information, expertise on grades and standards, availability of contractual agreements, existence of extensive social capital, group participation and reliance on traditions.
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  • Date Issued: 2010

Influence of mite predation on the efficacy of the gall midge Dasineura sp. as a biocontrol agent of Australian myrtle Leptospermum laevigatum (Myrtaceae) in South Africa

  • Authors: Mdlangu, Thabisa Lynette Honey
  • Date: 2010
  • Subjects: Dasyneura leguminicola , Myrtaceae -- South Africa , Mites as biological pest control agents , Pests -- Biological control , Biological pest control agents , Predation (Biology)
  • Language: English
  • Type: Thesis , Masters , MSc (Zoology)
  • Identifier: vital:11789 , http://hdl.handle.net/10353/272 , Dasyneura leguminicola , Myrtaceae -- South Africa , Mites as biological pest control agents , Pests -- Biological control , Biological pest control agents , Predation (Biology)
  • Description: Dasineura sp. is a gall forming midge that was introduced into South Africa for the biocontrol of the Australian myrtle, Leptospermum laevigatum. It causes galls on both the vegetative and reproductive buds of the plant. Although Dasineura sp. was initially regarded as a potentially successful agent, galling up to 99 percent of the buds of the host plant, it has been preyed on by native opportunistic mites, which caused a decline in the performance of the midge as a biocontrol agent of L. laevigatum. This raised a concern about whether this fly will be able to perform effectively in the presence of its new natural enemies. Therefore, the objectives of this study were to: 1) ascertain whether mite abundance has seasonal variations; 2) determine if plant density and plant size have an effect on midge predation by the mites; and 3) determine if midge predation varies in different locations. The study was conducted at three sites in the Hermanus area, Western Cape Province. Every three weeks for thirteen months, galls were collected and dissected so as to count and record the numbers of midge larvae, pupae, adults and mites that were found. Data collected showed that predation varied with season, and the mites were scarce during the flowering season. Predation also varied among the study sites and plant density had an effect on midge predation. Midges in smaller plants (saplings) were more vulnerable to predation than those in the bigger plants (plants from isolates and thickets). It was concluded that although mites have an effect on midge populations, they do not prevent their establishment on the plant. Therefore, a survey should be done in two to three years time to check if the midges are still persisting on the plant, vi and recommendations are that a new agent should be released to supplement the midges.
  • Full Text:
  • Date Issued: 2010
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