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Synergistic potententials and isolation of bioactive compounds from the extracts of two helichrysum species indigenous to the Eastern Cape province

  • Authors: Aiyegoro, Olayinka Ayobami
  • Date: 2010
  • Subjects: Helichrysum -- South Africa -- Eastern Cape , Antibiotics , Antioxidants , Medicinal plants -- South Africa -- Eastern Cape , Traditional medicine -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Doctoral , PhD (Microbiology)
  • Identifier: vital:11268 , http://hdl.handle.net/10353/250 , Helichrysum -- South Africa -- Eastern Cape , Antibiotics , Antioxidants , Medicinal plants -- South Africa -- Eastern Cape , Traditional medicine -- South Africa -- Eastern Cape
  • Description: Helichrysum longifolium and H. pedunculatum belong to the Astereceae family and are used extensively in folkloric medicine in South Africa to manage stress-related ailments and as dressings for wounds normally encountered in circumcision rites, bruises, cuts and sores. The in vitro antibacterial time-kill studies, the synergistic potentials, the phytochemical screenings and antioxidant potentials as well as the isolation of the bioactive compounds from the extracts of these two plants were carried out in this study. The in vitro antibacterial activities and time kill regimes of crude extracts of H. pedunculatum was assessed. The extracts was active against both Gram positive and Gram negative bacteria tested at a concentration of 10 mg/ml. Minimum Inhibitory Concentration (MIC) values for all the susceptible bacteria ranged between 0.1 – 35 mg/ml. The average log reduction in viable cell count in time kill assay ranged between 0.17 Log10 to 6.37 Log10 cfu/ml after 6 h of interaction, and between 0.14 Log10 and 6.99 Log10 cfu/ml after 12 h interaction in 1 × MIC and 2 × MIC of the extract. The effect of the aqueous extract was only bacteriostatic on both reference and environmental strains and the clinical isolates were outrightly resistant to aqueous extract. This is worrisome and this could be one reason why, there is an incidence of high death rate resulting from circumcision wounds infection even after treating such wounds with H. pedunculatum leaf. In vitro antibacterial time kill studies of extracts of H. longifolium was assessed. All test bacteria were susceptible to the methanol extract, while none was susceptible to the aqueous extract. Two of the test bacteria were susceptible to the ethyl acetate extract, while ten and seven were susceptible to the acetone and chloroform extracts respectively at the test concentration of 5 mg/ml. The minimum inhibitory concentrations (MICs) ranged between 0.1 and 5.0 mg/ml, while minimum bactericidal concentrations (MBCs) ranged between 1.0 and >5 mg/ml for all the extracts. Average log reductions in viable cell counts for all the extracts ranged between 0.1 Log10 and 7.5 Log10 cfu/ml after 12 h interaction at 1 × MIC and 2 × MIC. Most of the extracts were rapidly bactericidal at 2 × MIC achieving a complete elimination of most of the test organisms within 12 h exposure time. The effect of combinations of the crude extracts of H. pedunculatum leaves and eight antibiotics was investigated by means of checkerboard and time-kill methods. In the checkerboard method, synergies of between 45.83-56.81 percent were observed and this is independent of Gram reaction, with combinations in the aqueous extract yielding largely antagonistic interactions (18.75 percent). The time kill assay also detected synergy that is independent of Gram reaction with a ≥ 3Log10 potentiation of the bactericidal activity of the test antibiotics. We conclude that the crude leaf extracts of H. pedunculatum could be potential source of broad spectrum antibiotics resistance modulating compounds. The interactions between crude extracts of H. longifolium in combination with six first-line antibiotics using both the time-kill and the checkerboard methods were carried out. The time-kill method revealed the highest bactericidal activity exemplified by a 6.7 Log10 reduction in cell density against Salmonella sp. when the extract and Penicillin G are combined at ½ × MIC. Synergistic response constituted about 65 percent, while indifference and antagonism constituted about 28.33 percent and 6.67 percent in the time kill assay, respectively. The checkerboard method also revealed that the extracts improved bactericidal effects of the antibiotics. About 61.67 percent of all the interactions were synergistic, while indifference interactions constituted about 26.67 percent and antagonistic interactions was observed in approximately 11.66 percent. The in vitro antioxidant property and phytochemical constituents of the aqueous crude leaf extracts of H. longifolium and H. pedunculatum was investigated. The scavenging activity on superoxide anions, DPPH, H2O2, NO and ABTS; and the reducing power were determined, as well as the flavonoid, proanthocyanidin and phenolic contents of the extracts. The extracts exhibited scavenging activity in all radicals tested due to the presence of relatively high total phenol and flavonoids contents in the extracts. Our findings suggest that H. longifolium and H. pedunculatum are endowed with antioxidant phytochemicals and could serve as a base for future drugs. Bioactivity-guided fractionation of the leaves of H. longifolium and H. pedunculatum yielded two known compounds. From the n-hexane fraction of H. longifolium a compound was isolated (Stigmasterol) and from the ethyl acetate fraction of H. pedunculatum another compound (β-sitosterol) was isolated. The compounds were isolated and identified using various techniques. The antimicrobial, anti-inflammatory, antioxidant, analgesic and anti-pyretic activities of these compounds have been reported in literatures. In general, the experiments and tests conducted in this study appear to have justified the folkloric medicinal uses of H. longifolium and H. pedunculatum for the treatment of stress related ailments and wound infections and make a substantial contribution to the knowledge base of the use of herbal medicine for the treatment of the microbial infections.
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  • Date Issued: 2010

Syntheses and investigation of the effects of position and nature of substituent on the spectral, electrochemical and spectroelectrochemical properties of new cobalt phthalocyanine complexes

  • Authors: Akinbulu, Isaac A , Nyokong, Tebello
  • Date: 2010
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/261677 , vital:53434 , xlink:href="https://doi.org/10.1016/j.poly.2010.01.004"
  • Description: The syntheses of new cobalt phthalocyanine (CoPc) complexes, tetra-substituted with diethylaminoethanethio at the peripheral (complex 3a) and non-peripheral (complex 3b) positions, and with benzylmercapto at the non-peripheral position (complex 5), are reported. The effects of the nature and position of substituent on the spectral, electrochemical and spectroelectrochemical properties of these complexes are investigated. Solution electrochemistry of complex 3a showed three distinctly resolved redox processes attributed to CoIIIPc−2/CoIIPc−2 (E½ = +0.64 V versus Ag|AgCl), CoIIPc−2/CoIPc−2 (E½ = −0.24 V versus Ag|AgCl) and CoIPc−2/CoIPc−3 (E½ = −1.26 V versus Ag|AgCl) species. No ring oxidation was observed in complex 3a. Complex 3b showed both ring-based oxidation, attributed to CoIIIPc−1/CoIIIPc−2 species (Ep = +0.86 V versus Ag|AgCl), and ring-based reduction associated with CoIPc−2/CoIPc−3 species (E½ = −1.46 V versus Ag|AgCl), with the normal metal-based redox processes in CoPc complexes: CoIIIPc−2/CoIIPc−2 (Ep = +0.41 V versus Ag|AgCl) and CoIIPc−2/CoIPc−2 (E½ = −0.38 V versus Ag|AgCl). Solution electrochemistry of complex 5 showed the same type and number of species observed in complex 3a: CoIIIPc−2/CoIIPc−2 (Ep = +0.59 V versus Ag|AgCl), CoIIPc−2/CoIPc−2 (E½ = −0.26 V versus Ag|AgCl) and CoIPc−2/CoIPc−3 (E½ = −1.39 V versus Ag|AgCl) species. These processes were confirmed using spectroelectrochemistry.
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  • Date Issued: 2010

Synthesis and electrochemical characterisation of new tantalum (V) alkythio phthalocyanines

  • Authors: Chauke, Vongani , Nyokong, Tebello
  • Date: 2010
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/249093 , vital:51777 , xlink:href="https://doi.org/10.1016/j.ica.2010.05.003"
  • Description: The synthesis and electrochemical characterisation of octa-pentylthio (4a) and octa-octylthio (4b) – phthalocyaninato tantalum (III) hydroxide are hereby reported. These TaPc complexes absorb in the near infrared region (∼800 nm in dichloromethane). They show good solubility in most common solvents especially non-viscous solvents such as dichloromethane and chloroform. NMR, mass and infrared spectroscopy and elemental analysis confirmed the structures and purity of the synthesised complexes. The cyclic voltammograms (CVs) showed reversible reduction couples and irreversible oxidation peaks. The latter exhibited adsorption behavior. The reduction processes were observed at −0.74 and −1.13 V (versus Ag|AgCl) for 4a, and −0.67, −1.02 and −1.48 V (versus Ag|AgCl) for 4b. Spectroelectrochemistry confirmed one metal reduction, with the rest of the redox processes being centered on the phthalocyanine ring.
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  • Date Issued: 2010

Synthesis and photophysical properties of 1, 1′-binaphthol substituted phthalocyanines

  • Authors: Canlica, Meylude , Nyokong, Tebello
  • Date: 2010
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/249148 , vital:51782 , xlink:href="https://doi.org/10.1016/j.ica.2010.06.034"
  • Description: We report on the synthesis, characterization and photophysical properties of a new symmetrically tetra substituted {at non-peripheral positions with tetra(1,1′-bi-binaphtoxy)} phthalocyanines containing H2, Mg(II), Al(III)Cl, Si(IV)Cl2 in the central cavity. The synthesized compounds were characterized by the elemental analyses, UV–Vis, FT-IR and 1H NMR spectroscopies. The fluorescence quantum yields, triplet quantum yields and lifetimes of the newly synthesized H2, Mg, Al, and Si phthalocyanines were explored. Triplet quantum yields ranged from 0.24 to 0.54. The triplet lifetime for the silicon phthalocyanine derivative was the highest ever reported for a phthalocyanine (∼3.5 ms).
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  • Date Issued: 2010

Synthesis, characterization and reactions of novel ferrocenylimidazoles as donor ligands

  • Authors: Onyancha, Douglas Okerio
  • Date: 2010
  • Subjects: Ferrocene
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:10390 , http://hdl.handle.net/10948/1150 , Ferrocene
  • Description: In this project a series of ferrocenylimidazole derivatives were successfully prepared and characterized using an array of analytical techniques. Reactions of ferrocenylcarbinols with N,N′-thiocarbonyldiimidazole under both solvent-free conditions and in dichloromethane are described. The reaction of ferrocenylmethanol afforded S,S-bis(ferrocenylmethyl)dithiocarbonate, the reaction of α-substituted ferrocenylcarbinols provided ferrocenylalkylimidazolides, while ω-ferrocenylcarbinols yielded ferrocenylimidazolecarbothioates. The reactions were carried out under solvent-free conditions, consistent with the principles of Green Chemistry. Ferrocenyl benzyl ethers were successfully prepared by reacting 4-ferrocenylbenzyl-1Hcarboxylate with a series of primary alcohols under catalytic condition and under a catalyst– free environment. Refluxing a mixture of alcohol-water and 4-ferrocenylbenzyl-1Hcarboxylate provided the corresponding ethers in modest yields. The same ethers were obtained at room temperature by employing potassium tetrachloroplatinate or hydrochloric acid as catalyst. Ferrocenyl-1H-imidazole, 4-ferrocenylphenyl-1H-imidazole and their corresponding ferrocenyl-3-subsitituted imidazolium salts have been successfully synthesized. The compounds were characterized and the electrochemical properties of selected imidazolium salts were examined by cyclic voltammetry. Additionally, X-ray structures of two of the imidazolium salts were determined. The imidazolium salts were found to be good catalysts for the Heck and Suzuki cross-coupling reactions.
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  • Date Issued: 2010

Synthetic pathways to water-soluble phthalocyanines and close analogs

  • Authors: Dumoulin, Fabienne , Durmus, Mahmut , Ahsen, Vefa , Nyokong, Tebello
  • Date: 2010
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/249082 , vital:51776 , xlink:href="https://doi.org/10.1016/j.ccr.2010.05.002"
  • Description: The different types of water-soluble phthalocyanines are presented and their synthesis is reviewed.
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  • Date Issued: 2010

Systemic influence on Black South African adolescents' career development : adolescent and parental perspectives

  • Authors: Collett, Gary Reece
  • Date: 2010
  • Subjects: Career development -- South Africa , Teenagers -- Vocational guidance , Adolescence , Parent and child
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:9863 , http://hdl.handle.net/10948/1513 , Career development -- South Africa , Teenagers -- Vocational guidance , Adolescence , Parent and child
  • Description: Currently, no career theories exist that sufficiently explain the career development of South Africa’s diverse population groups. Consequently, South African researchers have been entirely dependent on international, western-informed career theories. While such theories have taken on a more ethnocentric complexion in recent times, they remain essentially decontextualised for South Africa. Furthermore, although the influence of family and the significant roles of parents have been theoretically acknowledged as critical influences in adolescent career development, there is still a considerable lack of research in South Africa on this topic. The present study therefore explored the perceptions of systemic influences on adolescent career development from the perspectives of both Black middle-class South African Grade 11 learners and their parents. The research was conceptualised within the Systems Theory Framework (STF) of career development and used its derivative instrument, the My Systems of Career Influences (MSCI, Adolescent). The present study utilised a qualitative research method, using answers derived from the MSCI (Adolescent) booklets to inform semi-structured interviews. The data analysis procedure involved the use of Interpretive Phenomenological Analysis to qualitatively analyse data obtained from the semistructured interviews. Findings revealed a number of influences within the individual system (personality, values, abilities), social system (adolescents’ parents and teachers) and societal-environmental system (financial support, the opportunity to work overseas, geographical location, job availability, and the location of universities) that were acknowledged as having an influence on the career development of South African Black middle class adolescents. Each of these findings were explored and unpacked under the four xii identified Interpretive Phenomenological Analysis (IPA) superordinate themes of Family Dynamics, Great Expectations, The Ghost of Apartheid and Coconuts Fall Far From the Tree. Lastly, the limitations of the present study, as well as recommendations for future research are discussed.
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  • Date Issued: 2010

Take my word for it: a new approach to the problem of sincerity in the epistemology of testimony

  • Authors: Dewhurst, Therese
  • Date: 2010
  • Subjects: Sincerity Philosophy Terminology Knowledge, Theory of Honesty
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:2707 , http://hdl.handle.net/10962/d1002837
  • Description: The epistemological problem of sincerity in testimony is often approached in the following way: We, as a matter of fact, accept utterances as sincere. We do so in the face of knowledge that people lie and deceive,and yet we still count these beliefs as good beliefs. Therefore there must be some reason or argument that we can cite in order to justify our acceptance of the sincerity of the speaker. In this thesis I will argue, contra this, that there is no reason, per se, that justifies our of a speakers sincerity: this is because recognition of the obligation to accept the sincerity is a necessary condition on the possibility of communication and interpretation. In the first three of the thesis I will argue against three of the main approaches to the problem by focusing on what I believe to be the strongest accounts of each: Elizabeth Fricker's reductionism, Tyler Burge's non-reductionism, and Paul Faulkner's trust account of testimony. In the final chapter I will put forward my positive account. I will argue that it is a constitutive rule of language that a speaker be sincere, and then make the further claim, that it is a constitutive rule of interpretation that the hearer take an utterance as sincere. On my account, successful communication does not just depend on a speaker making sincere utterances,but just as importantly,, on the hearer recognising an obligation to take those utterances as being sincere.
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  • Date Issued: 2010

Target costing as a strategic cost management tool in the South African motor industry

  • Authors: Slater, Michael, M A
  • Date: 2010
  • Subjects: Target costing -- South Africa , Strategic planning -- South Africa -- Management , Cost accounting -- South Africa -- Standards , Cost accounting -- South Africa , Cost control
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:8974 , http://hdl.handle.net/10948/1094 , Target costing -- South Africa , Strategic planning -- South Africa -- Management , Cost accounting -- South Africa -- Standards , Cost accounting -- South Africa , Cost control
  • Description: Traditional cost-accounting approaches have served manufacturers well over a long period, but due to the changing nature of the modern manufacturing environment shortcomings have resulted and are no longer regarded as suitable (Gagne & Discenza 1993: 68). Similarly, Monden and Lee (1993: 22) state that many practitioners and academicians have questioned the effectiveness of standard cost systems, which have been used as the primary cost control measure for the last several decades. Cooper and Slagmulder (1997: 2) point out that in contrast to the conventional cost management techniques, target costing adopts a feed-forward approach. The objective of target costing is to design costs out of products, and not to find ways of eliminating costs after the products enter production. Few firms can afford to ignore such a powerful mechanism to increase profits in today’s highly competitive environment.
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  • Date Issued: 2010

TB treatment initiation and adherence in a South African community influenced more by perceptions than by knowledge of tuberculosis

  • Authors: Cramm, Jane M , Finkenflügel, Harry J M , Moller, Valerie , Nieboer, Anna P
  • Date: 2010
  • Language: English
  • Type: Article
  • Identifier: vital:7101 , http://hdl.handle.net/10962/d1010657
  • Description: Background Tuberculosis (TB) is a global health concern. Inadequate case finding and case holding has been cited as major barrier to the control of TB. The TB literature is written almost entirely from a biomedical perspective, while recent studies show that it is imperative to understand lay perception to determine why people seek treatment and may stop taking treatment. The Eastern Cape is known as a province with high TB incidence, prevalence and with one of the worst cure rates of South Africa. Its inhabitants can be considered lay experts when it comes to TB. Therefore, we investigated knowledge, perceptions of (access to) TB treatment and adherence to treatment among an Eastern Cape population. Methods An area-stratified sampling design was applied. A total of 1020 households were selected randomly in proportion to the total number of households in each neighbourhood. Results TB knowledge can be considered fairly good among this community. Respondents' perceptions suggest that stigma may influence TB patients' decision in health seeking behavior and adherence to TB treatment. A full 95 percent of those interviewed believe people with TB tend to hide their TB status out of fear of what others may say. Regression analyses revealed that in this population young and old, men and women and the lower and higher educated share the same attitudes and perceptions. Our findings are therefore likely to reflect the actual situation of TB patients in this population. Conclusions The lay experts' perceptions suggests that stigma appears to effect case holding and case finding. Future interventions should be directed at improving attitudes and perceptions to potentially reduce stigma. This requires a patient-centered approach to empower TB patients and active involvement in the development and implementation of stigma reduction programs.
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  • Date Issued: 2010

Teaching conflict-sensitive journalism:

  • Authors: du Toit, Peter
  • Date: 2010
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/159449 , vital:40298 , https://hdl.handle.net/10520/EJC139358
  • Description: We expect court reporters to know something about the law, financial journalists to have a grounding in economics, and parliamentary correspondents to understand politics, but many journalists are ill-equipped handle social phenomenon that is ubiquitous to most beats - conflict.
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  • Date Issued: 2010

Teaching journalism to produce “interpretive communities" rather than just “professionals”:

  • Authors: Garman, Anthea
  • Date: 2010
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/159846 , vital:40349 , DOI: 10.1080/02560054.2005.9653330
  • Description: Debates about whether journalism is a “trade” and can only be learnt “on the job”, or whether journalism should even be taught at universities, are no longer fruitful or even interesting for teachers in tertiary environments. The far more important discussion around the teaching of journalism should be on the approach which focuses too exclusively on its nature as a “profession” and so ignores the critical function of journalists in the world as “interpretive communities”.
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  • Date Issued: 2010

Technology solutions to strengthen the integration of marginalized communities into the global knowledge society

  • Authors: Hlungulu, Bulumko , Kunjuzwa, Dumani , Ndlovu, Nyankiso , Samalenge, Jimmy , Sikhumbuzo, Ngwenya , Thinyane, Mamello , Terzoli, Alfredo
  • Date: 2010
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/430769 , vital:72714 , https://ieeexplore.ieee.org/abstract/document/5753005
  • Description: Information and Communication Technology (ICT) has made it possible to explore novel and innovative mechanisms to leap-frog socio-economic development in rural and marginalized communities. An ICT for development intervention called Siyakhula Living Lab (SLL) has been underway in Dwesa, a rural community in the Eastern Cape Prov-ince, for the past four years. The living lab methodology, which enables user-driven innovation within a multi-stakeholder relationship of aca-demia, user communities, government and private industry, has facili-tated greater integration of the Dwesa community into the digital ecolo-gy and subsequently the knowledge society. This paper introduces the SLL intervention, discusses the SLL's supporting technical infrastruc-ture and the interventions that are undertaken towards long-term sus-tainability of the project. The developed eServices are also discussed, with a view to highlighting the key characteristics that contribute to in-creased context-sensitivity, ownership, and buy-in from the community.
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  • Date Issued: 2010

The adoption of quality assurance in e-Health acquisition for rural hospitals in the Eastern Cape Province

  • Authors: Ruxwana, Nkqubela
  • Date: 2010
  • Subjects: Quality assurance -- Management , Hospital care -- Quality control , Health facilities -- Quality control , Health -- Computer network resources , Public health -- Information services
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:9731 , http://hdl.handle.net/10948/1514 , Quality assurance -- Management , Hospital care -- Quality control , Health facilities -- Quality control , Health -- Computer network resources , Public health -- Information services
  • Description: The evolution of e-health has the potential to assist in the management of scarce resources and the shortage of skills, enhance efficiencies, improve quality and increase work productivity within the healthcare sector. As a result, an increase is seen in e-health solutions developments with the aim to improve healthcare services, hospital information systems, health decision support, telemedicine and other technical systems that have the potential to reduce cost, improve quality, and enhance the accessibility and delivery of healthcare. However, unfortunately their implementation contiues to fail. Although there are several reasons for this, in this study a lack of project quality management is viewed as a key contributor to the failure of e-health solutions implementation projects in rural hospitals. This results in neglected aspects of quality assurance (QA), which forms an integral part of project quality management. The purpose of this study is to develop a Genertic Quality Assurance Model (GQAM) for the successful acquisition (i.e. development and implementation) of e-health solutions in rural hospitals in the Eastern Cape Province to enable improved quality of care and service delivery. In order to develop and test this model it was necessary to identify the QA methodologies that are currently used in rural hospitals and to evaluate their strengths and weaknesses, as well as their impact on project success. The study is divided into four phases; in each phase different study designs were followed. The study used triangulation of qualitative and some elements of quantitative research approaches, in terms of which a case study approach was adpoted to answer the research questions. This study did indeed develop a GQAM that can be used to ensure e-health solution success in rural hospitals. Furthermore, to aid in the implementation of this model, a set of QA value chain implementation guidelines were developed, as a framework, to inject the nodel into typical (SDLC) phases.
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  • Date Issued: 2010

The advent of the 'Festivore' an exploration of South African audience attendance in the performing arts at the National Arts Festival

  • Authors: Antrobus, Richard Roy
  • Date: 2010
  • Subjects: Standard Bank National Arts Festival -- Economic aspects , Arts -- Economic aspects , Performing arts festivals -- Economic aspects -- South Africa -- Grahamstown , Arts -- South Africa -- Economic aspects , Arts -- South Africa -- Finance , Arts -- South Africa -- Political aspects , Arts audiences -- South Africa
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:2130 , http://hdl.handle.net/10962/d1002362
  • Description: In South Africa, the performing arts have contributed to enhancing national identity and distinctiveness despite coming up against weak legislation, policy and infrastructure to support their growth and proliferation (Fredericks, 2005: 9). Coupled with a decline in both government and consumer support and the contradictory disparity between valuing the arts and the funding of the arts, theatre companies can no longer rely on the comfort of external subsidies and financial support. In order to be economically viable and sustainable to ensure their survival, there is an increasing demand for theatre companies to look to novel ways of increasing audience demand for theatre and improving audience attendance. However, instead of risking artistic integrity and the performance product to satisfy the market, this research suggests that promotion and development of theatre at arts festivals provides a platform to access a wider theatre-going public, which therefore facilitates a change in the market focus toward appreciation of the product (production). It explores leading arguments pertaining to the attendance of arts and cultural events, namely, Peterson and Simkus (1992), later updated by Peterson‟s (2005)„omnivore-univore‟ argument. The argument purports cultural consumption as binary in nature: either significant and diverse or limited, if not absent altogether. Supported by a number of case-studies, including Chan and Goldthorpe (2005) and Montgomery and Robinson (2008) and Snowball et al. (2009), the investigation challenges Bourdieu‟s (1984) theory on cultural distinction as well as the homology and individualisation argument. In determining the factors that influence cultural taste and consumer behaviour, including motivators and inhibitors of attendance and a predominant emphasis on audience risk and information asymmetry, the research was placed in a local context, providing an overview of the socio-economic theatre environment in South Africa. It investigated the nature, structure and impact of local festivals (as events) in changing audience demand and theatre attendance. With specific reference to the South African National Arts Festival (NAF) the research notes the effects of Hauptfleisch‟s „eventification‟ phenomenon on univore attenders and therefore expands the omnivore-univore theory to include a new breed of attender: the “Festivore”. A case study explored the “Festivore” hypothesis through empirical research, surveys and face-to-face qualitative interviews and on-seat questionnaire responses by festival attenders. Personal interviews and communication was also carried out with leading experts in the field. The data was then analysed using SPSS 13 electronic statistical analysis programme to determine the socio-demographics and the factors that affect theatre attendance of existing, as well as potential target, theatre audiences at the National Arts Festival The study concluded that South African theatre attenders are generally omnivorous consumers and that, more importantly, there seems to be a shift towards „festivorous‟ consumption. Furthermore, evidence supports the development and proliferation of festivals as a means not only to support and promote the arts in South Africa but, more importantly, to generate new theatre audiences and entrench theatre attendance into South African culture.
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  • Date Issued: 2010

The ambivalence of African elitehood:

  • Authors: Matthews, Sally
  • Date: 2010
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/142442 , vital:38080 , DOI: 10.1177/0021909609357416
  • Description: Recent discussions in South Africa about the role of the so-called patriotic bourgeoisie highlight the much debated question of what role elite Africans can and ought to play in the upliftment of the poor. Those supporting the notion of a patriotic bourgeoisie believe that national or racial solidarity is sufficient to allow privileged Africans to act in the interests of their poorer fellow citizens. However, a reconsideration of an older discussion of African elitehood, that of Amilcar Cabral, suggests that something more may be needed before elites can act in the interests of the poor. Cabral argues that elites need to renounce their privilege and to live and struggle alongside the poor if pro-poor societal transformation is to be achieved. While Cabral may be right that shared racial or national identity is insufficient for elite solidarity with the poor, he does not consider all the complexities that arise when elites actually try to work with and for the poor. A consideration of the experiences of a long-standing Senegalese NGO reveal some of these complexities and suggest that any attempt by African elites to engage meaningfully in the upliftment of the poor, will inevitably involve continuous and difficult negotiation between paternalism and naïve egalitarianism.
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  • Date Issued: 2010

The anticancer activity of Cyathula prostrata on two malignant cell lines

  • Authors: Schnablegger, Gerald
  • Date: 2010
  • Subjects: Medicinal plants
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:10309 , http://hdl.handle.net/10948/1563 , Medicinal plants
  • Description: Plants have always been a source of medicine and are still being used by traditional healers in the rural part of Africa, Asia and India to treat a range of illnesses including cancer. The in vitro anticancer activity of an 80 percent ethanol extract of Cyathula prostrata, an annual branching shrub used by traditional healers in Nigeria to treat cancer was investigated. No previous studies have outlined the possible pathways and mechanisms used by cancer cells when treated with C. prostrata. Dose response analysis was performed to determine the effective cytotoxic concentrations of C. prostrata on HeLa (cervical cancer cell line) and U937 (myelo-monocytic cell line). The IC50 values were 100.8 μg/ml and 64.4 μg/ml for HeLa and U937 cells, respectively. All further experiments were performed using 125 μg/ml C. prostrata extract and 50 μM cisplatin as positive control. With the use of the fluorescent DNA binding dye propidium iodide, the induction of tumour cell death by C. prostrata extract has been linked to cell cycle arrest in the G1 phase at 24 and 48 h. In both cell lines, more than 80 percent of the C. prostrata treated cells were found in the G1 phase after 48 hours of treatment. The annexin V-FITC/PI assay revealed an increase in the percentage apoptotic cells from 4.9 percent to 53.1 percent at 24 h and 8.3 percent to 50.3 percent at 48 h. Since apoptosis induction can occur via a number of different pathways, distinct features were used as markers to investigate the mode of action of this C. prostrata extract. Markers such as activated caspase-8, p21 and cyt-c, were investigated with the aid of fluorescently labelled (FITC) antibodies with analysis using flow cytometry. No change in p21 levels was observed in response to treatment with the extract for up to 48 h. Cell cycle arrest in G1 was therefore not induced by this cyclin-CDK inhibitor. Increase in caspase-8 activation was observed in response to treatment with the extract with no cyt-c release from the mitochondria. The lack of cyt-c release was due to no change in mitochondrial membrane potential, which was investigated with the aid of fluorescent mitochondrial dyes and flow cytometric techniques. Caspase-8 activation is unique to the extrinsic apoptotic pathway. The results from this study therefore show that C. prostrata extract induces apoptosis via the extrinsic pathway and that this activation in independent of the mitochondria. The levels of hTERT, the catalytic subunit of telomerase, were investigated as an additional molecular target for C. prostrata. This was also investigated using FITC labelled antibodies and flow cytometry. A decrease in hTERT levels was observed following C. prostrata treatment. The findings from this study suggest that the extract acts through multiple targets, by inducing: cell cycle arrest in the G1 phase through an unknown mechanism; apoptosis through an extrinsic death receptor pathway and replicative senescence through inhibition of telomerase.
  • Full Text:
  • Date Issued: 2010

The applicability of the promotion of Administrative Justice Act in review of CCMA arbitration awards

  • Authors: Phanyane, Namadzavho California
  • Date: 2010
  • Subjects: Arbitration (Administrative law) -- South Africa , Arbitration and award -- Law and legislation -- South Africa
  • Language: English
  • Type: Thesis , Masters , LLM
  • Identifier: vital:10219 , http://hdl.handle.net/10948/1282 , Arbitration (Administrative law) -- South Africa , Arbitration and award -- Law and legislation -- South Africa
  • Description: South Africa’s employment law has undergone more frequent and dynamic changes than any area of the law, in recent years. The ability of employers and employees to regulate their respective rights and duties vis-à-vis each other by independent agreement has been progressively whittled down by statutory intervention. In so limiting the capacity of parties to the employment relationship to regulate the nature of their relationship, South Africa has followed development in Western industrialised nations. Against this background, the drafters of the Labour Relations Act1 (LRA), as amended, proposed a comprehensive framework of law governing the collective relations between employers and trade unions in all sectors of the economy. The LRA2 created a specialised set of forums and tribunals to deal with labour and employment related matters. It established Bargaining Councils, the Commission for Conciliation Mediation and Arbitration (CCMA), the Labour Court (LC) and the Labour Appeal Court (LAC). It also created procedures designed to accomplish the objective of simple, inexpensive and accessible resolution of labour disputes. In redesigning labour law, the legislature decided that some disputes between employers and employees should be dealt with by arbitrators and others by judges. It is this distinction that resulted in the creation of the CCMA and the Labour Court to perform arbitration and adjudication respectively. The result of adjudication is generally subject to appeal to a higher court. The result of arbitration is generally subject to review. Arbitration was given statutory recognition in South Africa by the Arbitration Act3. That Act provides a framework within which parties in dispute may if they wish appoint their own “judge” and supply him or her with their terms of reference tailored to their needs. With the foregoing in mind, the purpose of this work is the provision of a selection of landmark cases that dealt with the review function of CCMA awards. This selection 1 Act 66 of 1995 as amended comprises of landmark judgments of the different courts of the land. The study uses, as it departure point, legislative framework to elicit the extent to which review is extended to the litigants. Apart from looking at the legislative provisions towards review grounds, reference is made to specific landmark judgments that have an effect on this subject in order to provide a comprehensive and explicit picture of how CCMA arbitration awards may be taken on review. This study focuses on substantive law developed by the Labour Court, High Court, Supreme Court of Appeal and finally the Constitutional Court. This is informed by the very nature and scope of the study because any concentration on procedural and evidentiary aspects of review could lead to failure to achieve the objectives of the study. It looks at specific South African case law, judgments of the courts and the jurisprudence in the field of employment law so that the reader is presented with a clearer picture of recent developments in addressing review of arbitration awards. The concluding remarks are drawn from a variety of approaches used by the authorities in the field of employment law in dealing with review of CCMA arbitration awards and issues for further research are highlighted.
  • Full Text:
  • Date Issued: 2010

The attitudes of isiXhosa-speaking students toward language of learning and teaching issues at Rhodes University, South Africa: General trends1

  • Authors: Aziakpono, Philomena , Bekker, Ian
  • Date: 2010
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/469212 , vital:77220 , https://doi.org/10.2989/16073614.2010.488442
  • Description: This paper, selectively based on the results of Aziakpono (2007), examines the beliefs of isiXhosa-speaking students and in the process reveals their attitudes toward various languages of learning and teaching (LOLT) issues at Rhodes University, South Africa. The relevant data were gathered using a survey questionnaire and interviews (individual and focus group).
  • Full Text:
  • Date Issued: 2010

The biology of austroglanis gilli and austroglanis barnardi (siluriformes : austroglanididae) in the Olifants River system, South Africa

  • Authors: Mthombeni, Vusi Gedla
  • Date: 2010
  • Subjects: Catfishes -- South Africa -- Olifants River , Fishes -- South Africa -- Olifants River -- Growth , Freshwater fishes -- Effect of pesticides on -- South Africa -- Olifants River
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:5370 , http://hdl.handle.net/10962/d1015222
  • Description: Austroglanis gilli and A. barnardi are endemic to the Clanwilliam-Olifants System in the Western Cape, South Africa. The populations of each of these species are considered to be threatened by various anthropogenic activities, which include inappropriate agricultural practice and impacts of alien invasive fish species. The purpose of this thesis was to assess the life-history of these two endangered species in order to contribute to understanding their biology. Such information is vital for the development of strategies for their conservation. Marginal zone and marginal increment analyses from sectioned lapilliar otoliths of both A. gilli and A. barnardi showed a unimodal peak, suggesting a single annulus formation. The oldest specimens of A. gilli and A. barnardi were 12+ and 14+ years, respectively. The growth of A. gilli and A. barnardi was relatively slow and was best described by the von Bertalanffy growth curve as: L, = 131.56(1 - exp(- 0.27(t - 1.18 ))) for male and L, = 113.86(1 - exp(- 0.43(1- 0.74))) for female A. gilli from the Rondegat River. In the Noordhoeks River, growth was L, = 99.67(1 - exp(- 0.53(t - 0.35))) for male and L, = 96.60(1 - exp(- 0.64(t - 0.11 ))) for female A. gilli, and L, =71.02(1-exp(-0.26(1-3.07))) and L, = 69.50(1-exp(-0.36(1 - 1.88))) for male and female A. barnardi, respectively. The average natural mortality for the combined sexes was estimated using catch curve analysis at 0.37 ± 0.12 per year for A. gilli from the Rondegat River, and at 0.71 ± 0.05 and 0.39 ± 0.04 per year for A. gilli and A. barnardi from the Noordhoeks River, respectively. For A. gilli in the Rondegat River, the first maturity was estimated at 3.3 years (97.3 mm SL) for males and 3.1 years (94.3 mm SL) for females. In the Noordhoeks River, the first maturity for A. gilli was estimated at 2.0 years (71.9 mm SL) for males and 1.7 (66.4 mm SL) for females, and for A. barnardi at 2.0 (55.0 nun SL) for males and 2.9 years (58.9 mm SL) for females. Maturity corresponded closely to the asymptotic sizes from the von Bertalanffy curves, suggesting a shift in energy use from somatic growth to gonad development. Macroscopic assessment of the state of gonads, the Ganado-somatic index and histological examinations revealed that both A. gilli and A. barnardi have a single spawning season. The presence of oocytes in different stages of development in each of the ovaries of mature females collected between November and January suggested asynchronous, iteroperous serial spawning. The resorption of yolk was observed from ovaries collected between February and March and no vitellogenic oocyte was visible from ovaries collected between April and August. A similar trend was observed for males, with spermatozoa filling the lumen between November and January and some residual spermatozoa being present in the lumens soon after the breeding season. Spermatocytes and spermatids were dominant in the testes until October. An Index of Relative Importance revealed that A. gilli feeds predominantly on the benthic macroinvertebrate larvae of Ephemeroptera (particularly Baetidae), Diptera (particularly Chironomidae and Simuliidae) and Trichoptera. Austroglanis barnardi feeds predominantly on dipteran larvae (particularly Chironornidae and Simuliidae). Chi square contingency tables showed a significant difference in the dominant prey items of A. gilli and A. barnardi in the Noordhoeks River (X₂= 53.79, d.f. = 4, p > 0.001) and A. gilli between Rondegat and Noordhoeks rivers (x₂ = 34.74, d.f. = 4, p > 0.001). The Spearman's rank correlation test showed no shifts in the diet of A. barnardi from Noordhoeks River and A. gilli from Rondegat River with a change in size and season (p>O.OS). However, there was a shift in the diet of A. gilli from the Noordhoeks River which could suggest a distinct patchiness of benthic macroinvertebrates between the riffle feeding areas used by juveniles and other biotopes used by adults. The occurrence, in stomach contents, of other prey items from a wide variety of taxa and the presence of allochthonous material from the terrestrial environment could suggest an opportunistic feeding guild for both Austroglanis species. The life-history traits of A. gilli and A. barnardi, which are charaterized by slow growth, long life span and low relative fecundity, indicate that both species are relatively precocial and K-selected. The population of a precocial species is relatively stable and if population numbers were to be greatly reduced, they would require a long time to rebuild. An urgent conservation intervention is therefore recommended for Austroglanis spp. so as to maintain the diversity of populations within these species. The creation of protected river reserves and raising public conservation awareness may minimise activities that result in altered river hydrology and the destruction of complex benthic habitats.
  • Full Text:
  • Date Issued: 2010
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