Investigating deep-seated factors that can condition English First Additional Language literature teaching in Grade 7
- Authors: Ntikinca, Xolela
- Date: 2024-10-11
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/463757 , vital:76438
- Description: Access restricted. Expected release in 2026. , Thesis (MEd) -- Faculty of Education, Institute for the Study of Englishes of Africa, 2024
- Full Text:
- Date Issued: 2024-10-11
- Authors: Ntikinca, Xolela
- Date: 2024-10-11
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/463757 , vital:76438
- Description: Access restricted. Expected release in 2026. , Thesis (MEd) -- Faculty of Education, Institute for the Study of Englishes of Africa, 2024
- Full Text:
- Date Issued: 2024-10-11
Exploring the role of herbivory in Albany Subtropical Thicket restoration
- Authors: Hunt, Kristen Louise
- Date: 2024-04
- Subjects: Shrubs -- South Africa , Portulacaria afra -- South Africa , Grasslands -- South Africa , Plant communities -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/64060 , vital:73647
- Description: This dissertation attempted to investigate the influence of herbivory on the success of thicket restoration, addressing a critical gap in the current knowledge within the restoration initiative. Despite two decades of thicket restoration practices, the role of herbivory in influencing restoration success has been assumed and not yet quantified. This research aimed to observe and identify herbivore species and their interactions that may affect the survival of Portulacaria afra Jacq. material planted in thicket restoration contexts. This research took place on three game farms serving as case studies within the Albany Subtropical Thicket (Eastern Cape, South Africa). Multiple experiments were conducted to assess how the concept of different “natural refugia” might impact herbivore interactions with planted material, incorporating factors such as planting around rainfall, within open and semi-intact vegetation patches, and in proximity to water sources. Trail cameras were used for real-time monitoring of herbivore interactions within planted sites to understand and quantify herbivore interactions with P. afra cuttings and how they may impact plant survival. Results from the trail camera monitoring (Chapter 2) indicate varied herbivore interactions occurring on planted material, with the primary herbivore responsible for these interactions varying among farms. Species interactions were not consistent across farms, and herbivore interactions exhibited spatial and temporal variability. Notably, interactions declined soon after the start of the wet phase when surrounding vegetation could recover, indicating the influences of alternative forage availability on herbivore foraging choices. Different herbivore interactions were identified and quantified through trail camera images, ranging from minor biomass removal (estimated at <5 cm of stem and leaf material) to more detrimental actions such as uprooting and leaf stripping. Consistently, planted P. afra survival rates (Chapter 3) were significantly higher for protected material than those exposed to herbivores, regardless of whether planted in a dry or wet phase. Moreover, when exposed to herbivores, rooted material had significantly higher survival rates than unrooted material, indicating the potential advantage of a well-developed root system in faster recovery after a herbivory event. This research explored the influence of various factors, including rainfall, rooting state, protection, surrounding vegetation, and proximity to water, on P. afra survival and how some of these factors may affect P. afra survival in relation to herbivore interactions (Chapter 3). Significant differences in cutting survival were observed between dry and wet phases, rooted and unrooted material, and material protected vs exposed to herbivores. While survival was not significantly different in experiments involving surrounding vegetation and proximity to water, potential patterns were identified, warranting further investigation. A clipping and defoliation experiment under simulated seasonal conditions emphasised the significance of , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2024
- Full Text:
- Date Issued: 2024-04
- Authors: Hunt, Kristen Louise
- Date: 2024-04
- Subjects: Shrubs -- South Africa , Portulacaria afra -- South Africa , Grasslands -- South Africa , Plant communities -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/64060 , vital:73647
- Description: This dissertation attempted to investigate the influence of herbivory on the success of thicket restoration, addressing a critical gap in the current knowledge within the restoration initiative. Despite two decades of thicket restoration practices, the role of herbivory in influencing restoration success has been assumed and not yet quantified. This research aimed to observe and identify herbivore species and their interactions that may affect the survival of Portulacaria afra Jacq. material planted in thicket restoration contexts. This research took place on three game farms serving as case studies within the Albany Subtropical Thicket (Eastern Cape, South Africa). Multiple experiments were conducted to assess how the concept of different “natural refugia” might impact herbivore interactions with planted material, incorporating factors such as planting around rainfall, within open and semi-intact vegetation patches, and in proximity to water sources. Trail cameras were used for real-time monitoring of herbivore interactions within planted sites to understand and quantify herbivore interactions with P. afra cuttings and how they may impact plant survival. Results from the trail camera monitoring (Chapter 2) indicate varied herbivore interactions occurring on planted material, with the primary herbivore responsible for these interactions varying among farms. Species interactions were not consistent across farms, and herbivore interactions exhibited spatial and temporal variability. Notably, interactions declined soon after the start of the wet phase when surrounding vegetation could recover, indicating the influences of alternative forage availability on herbivore foraging choices. Different herbivore interactions were identified and quantified through trail camera images, ranging from minor biomass removal (estimated at <5 cm of stem and leaf material) to more detrimental actions such as uprooting and leaf stripping. Consistently, planted P. afra survival rates (Chapter 3) were significantly higher for protected material than those exposed to herbivores, regardless of whether planted in a dry or wet phase. Moreover, when exposed to herbivores, rooted material had significantly higher survival rates than unrooted material, indicating the potential advantage of a well-developed root system in faster recovery after a herbivory event. This research explored the influence of various factors, including rainfall, rooting state, protection, surrounding vegetation, and proximity to water, on P. afra survival and how some of these factors may affect P. afra survival in relation to herbivore interactions (Chapter 3). Significant differences in cutting survival were observed between dry and wet phases, rooted and unrooted material, and material protected vs exposed to herbivores. While survival was not significantly different in experiments involving surrounding vegetation and proximity to water, potential patterns were identified, warranting further investigation. A clipping and defoliation experiment under simulated seasonal conditions emphasised the significance of , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2024
- Full Text:
- Date Issued: 2024-04
Investigation of brewery waste grains and microbial fuel cells as value-additive technologies improving solvent production yields in Clostridium acetobutylicum (ATCC 824) fermentation
- Authors: Du Toit, Ryan Guillaume
- Date: 2023-10-13
- Subjects: Biomass energy , Butanol , Fermentation , Microbial fuel cells , Brewery waste , Clostridium acetobutylicum
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/424643 , vital:72171
- Description: The production of the solvent compounds acetone, ethanol and butanol through fermentation of organic feedstocks using Clostridia species could be a promising route for biofuel production. However, the cost of raw materials, low yields and the complexity of anaerobic fermentation continue to hinder this means of generating these compounds. The research presented in this Thesis investigated low-cost interventions that could decrease the costs of production and to direct the synthesis of fuel compounds using microbial fuel cells. Low-cost anaerobic chambers were designed and constructed for the propagation and manipulation of Clostridium acetobutylicum, selected as a low-risk microbial catalyst. Fermentation was monitored using in situ pH measurements and a combination of turbidity measurements, nutrient assays (especially total carbohydrates) and HPLC-RI detection as a means of monitoring the consumption of nutrients (glucose), production of precursor compounds (butyric acid) and the formation of solvent molecules (acetone/ethanol and butanol) during fermentation by this organism. Brewer’s spent grains were tested as a sustainable and low-cost feedstock for solvent production, comparing the effects of sterilising before fermentation, or allowing resident microflora to remain during Clostridium-catalysed solvent production. Sterilised spent grains significantly improved the production of solvent molecules (e.g. 12.97 ± 0.38 g/L of butanol yielded, compared to 0.40 ± 0.33 g/L for defined media sampled during the solventogenic phase); compared to these, the use of non-sterilised brewer’s grain decreased both the reproducibility and yields of fermentation (8.66 ± 1.6 g/L of butanol). Microbial fuel cells were studied as a possible means of altering electron transfer to/from electrode-attached Clostridia to control the metabolic shift in bacteria from acidogenesis to solventogenesis. The base line MFC (11.00 ± 4.69 g/L) fermentation experiment did produce higher acetone/ethanol than the baseline batch experiment MB (5.47 ± 4.48 g/L), indicating an improvement to solvent production in C. acetobutylicum (ATCC 824) in a MFC fermentation. In this study, MFC-1 demonstrated remarkable superiority over MB in terms of butyric acid production, yielding significantly higher concentrations while also improving acetone and ethanol production. However, the enhanced butyric acid production did not correspond to significantly increased butanol yields when compared to batch fermentation of chemically defined media. These findings highlight the potential of MFC-1 as an efficient approach for enhancing the fermentative production of valuable compounds, with a particular focus on butyric acid and acetone/ethanol. , Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2023
- Full Text:
- Date Issued: 2023-10-13
- Authors: Du Toit, Ryan Guillaume
- Date: 2023-10-13
- Subjects: Biomass energy , Butanol , Fermentation , Microbial fuel cells , Brewery waste , Clostridium acetobutylicum
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/424643 , vital:72171
- Description: The production of the solvent compounds acetone, ethanol and butanol through fermentation of organic feedstocks using Clostridia species could be a promising route for biofuel production. However, the cost of raw materials, low yields and the complexity of anaerobic fermentation continue to hinder this means of generating these compounds. The research presented in this Thesis investigated low-cost interventions that could decrease the costs of production and to direct the synthesis of fuel compounds using microbial fuel cells. Low-cost anaerobic chambers were designed and constructed for the propagation and manipulation of Clostridium acetobutylicum, selected as a low-risk microbial catalyst. Fermentation was monitored using in situ pH measurements and a combination of turbidity measurements, nutrient assays (especially total carbohydrates) and HPLC-RI detection as a means of monitoring the consumption of nutrients (glucose), production of precursor compounds (butyric acid) and the formation of solvent molecules (acetone/ethanol and butanol) during fermentation by this organism. Brewer’s spent grains were tested as a sustainable and low-cost feedstock for solvent production, comparing the effects of sterilising before fermentation, or allowing resident microflora to remain during Clostridium-catalysed solvent production. Sterilised spent grains significantly improved the production of solvent molecules (e.g. 12.97 ± 0.38 g/L of butanol yielded, compared to 0.40 ± 0.33 g/L for defined media sampled during the solventogenic phase); compared to these, the use of non-sterilised brewer’s grain decreased both the reproducibility and yields of fermentation (8.66 ± 1.6 g/L of butanol). Microbial fuel cells were studied as a possible means of altering electron transfer to/from electrode-attached Clostridia to control the metabolic shift in bacteria from acidogenesis to solventogenesis. The base line MFC (11.00 ± 4.69 g/L) fermentation experiment did produce higher acetone/ethanol than the baseline batch experiment MB (5.47 ± 4.48 g/L), indicating an improvement to solvent production in C. acetobutylicum (ATCC 824) in a MFC fermentation. In this study, MFC-1 demonstrated remarkable superiority over MB in terms of butyric acid production, yielding significantly higher concentrations while also improving acetone and ethanol production. However, the enhanced butyric acid production did not correspond to significantly increased butanol yields when compared to batch fermentation of chemically defined media. These findings highlight the potential of MFC-1 as an efficient approach for enhancing the fermentative production of valuable compounds, with a particular focus on butyric acid and acetone/ethanol. , Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2023
- Full Text:
- Date Issued: 2023-10-13
A proposed management framework for water stewardship for small business in South Africa
- Authors: Huxtable, Collette
- Date: 2022-12-12
- Subjects: Water-supply Management , Small business South Africa , Water-supply Economic aspects , Triple bottom line , Sustainable development reporting , Competitive advantage
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/419090 , vital:71615
- Description: Climate change, severe weather events, population growth and, urbanisation are just a few of the leading causes contributing to the global water crisis. This global water crisis is negatively impacting the environment, and society, which includes business (large and small). Businesses are facing many water risks and challenges in their daily operations, such as water scarcity, water stress and water pollution, which are resulting in them being negatively impacted financially. For all business to overcome these risks and challenges which are negatively impacting their operations and to assist in protecting the scarce water resources left on the planet, the implementation of water stewardship practices will play a very important role. The literature has fallen short in addressing water stewardship frameworks and practices for small business. Through a sustainability lens underpinned by Natural Resource Based View Theory, this research study sets out to develop a water stewardship framework for implementation by small business to provide them with a competitive advantage. By reviewing the current literature and frameworks available to large business organisations, the insights gained allowed for a draft water stewardship framework to be developed from this literature, suitable for small business. This draft water stewardship framework for small business was used to gather further information on its suitability for small business, through an interview process. A qualitative interview process with seven small businesses in Makhanda (South Africa), allowed for data to be gathered and used to refine and adjust the draft water stewardship framework for small business. The findings from this research study show that small business do not have a global awareness of water problems and are not aware of the concept of water stewardship. Small business were very receptive to the draft water stewardship framework for small business and felt that its implementation would make a difference in saving scarce water resources and create a competitive advantage for them. The study concludes by recommending a water stewardship framework for small business (WSF4SB), who will play a leading role in fighting the water crisis. The implementation of the WSF4SB aims to provide small business with a sustainable competitive advantage by looking after scarce water resources ensuring there is sufficient water for current and future generations. , Thesis (MBA) -- Faculty of Commerce, Rhodes Business School, 2023
- Full Text:
- Date Issued: 2022-12-12
- Authors: Huxtable, Collette
- Date: 2022-12-12
- Subjects: Water-supply Management , Small business South Africa , Water-supply Economic aspects , Triple bottom line , Sustainable development reporting , Competitive advantage
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/419090 , vital:71615
- Description: Climate change, severe weather events, population growth and, urbanisation are just a few of the leading causes contributing to the global water crisis. This global water crisis is negatively impacting the environment, and society, which includes business (large and small). Businesses are facing many water risks and challenges in their daily operations, such as water scarcity, water stress and water pollution, which are resulting in them being negatively impacted financially. For all business to overcome these risks and challenges which are negatively impacting their operations and to assist in protecting the scarce water resources left on the planet, the implementation of water stewardship practices will play a very important role. The literature has fallen short in addressing water stewardship frameworks and practices for small business. Through a sustainability lens underpinned by Natural Resource Based View Theory, this research study sets out to develop a water stewardship framework for implementation by small business to provide them with a competitive advantage. By reviewing the current literature and frameworks available to large business organisations, the insights gained allowed for a draft water stewardship framework to be developed from this literature, suitable for small business. This draft water stewardship framework for small business was used to gather further information on its suitability for small business, through an interview process. A qualitative interview process with seven small businesses in Makhanda (South Africa), allowed for data to be gathered and used to refine and adjust the draft water stewardship framework for small business. The findings from this research study show that small business do not have a global awareness of water problems and are not aware of the concept of water stewardship. Small business were very receptive to the draft water stewardship framework for small business and felt that its implementation would make a difference in saving scarce water resources and create a competitive advantage for them. The study concludes by recommending a water stewardship framework for small business (WSF4SB), who will play a leading role in fighting the water crisis. The implementation of the WSF4SB aims to provide small business with a sustainable competitive advantage by looking after scarce water resources ensuring there is sufficient water for current and future generations. , Thesis (MBA) -- Faculty of Commerce, Rhodes Business School, 2023
- Full Text:
- Date Issued: 2022-12-12
High road or common neoliberal trajectory? Collective bargaining, wage share, and varieties of capitalism
- Mpuku, Mutale Natasha Muchule
- Authors: Mpuku, Mutale Natasha Muchule
- Date: 2022-10-14
- Subjects: Collective bargaining , Globalization , Labor union members , Wages Statistics , Income distribution , Economic development , Neoliberalism , Capitalism
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/357611 , vital:64760
- Description: Wage shares have been falling since the 1980s across developing and developed countries. There has also been a downward trend with labour market institutions in these countries, with a few exceptions. This thesis analyzes these trends using firstly an extended literature review and secondly an econometrics analysis of a panel of 36 countries over 39 years. The extended literature review identified two broad competing narratives surrounding this topic: the mainstream and the alternative growth narratives. They both focus on two different growth regimes, the former, posits that growth is profit-led and the latter that growth is wage-led. Both are not ‘zero sum’ processes and seem to offer the same end result (growth and development). However, profit-led growth seems to have two problems. First, at least in the medium run, there is a trade-off between growth and income distribution. And secondly, profit-led growth is contradictory at the global level. Wage-led growth, which offers a ‘high road’ approach, seems far more appealing. Furthermore, several authors, including in South Africa, have claimed that regime-switching (to wage-led growth), is possible, and it seems that labour market institutions may play an important role in facilitating such a switch. However, the empirical literature, especially regarding middle- and low-income countries, is sparse and inconclusive. The panel data analysis provided by this thesis was not conclusive in establishing whether the wage-led, high road path is still viable for countries like South Africa. However, it did not find strong evidence of the contrary. The thesis concluded that there is scope for further research in this field and makes certain suggestions in this regard. , Thesis (MCom) -- Faculty of Commerce, Economics and Economic History, 2022
- Full Text:
- Date Issued: 2022-10-14
- Authors: Mpuku, Mutale Natasha Muchule
- Date: 2022-10-14
- Subjects: Collective bargaining , Globalization , Labor union members , Wages Statistics , Income distribution , Economic development , Neoliberalism , Capitalism
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/357611 , vital:64760
- Description: Wage shares have been falling since the 1980s across developing and developed countries. There has also been a downward trend with labour market institutions in these countries, with a few exceptions. This thesis analyzes these trends using firstly an extended literature review and secondly an econometrics analysis of a panel of 36 countries over 39 years. The extended literature review identified two broad competing narratives surrounding this topic: the mainstream and the alternative growth narratives. They both focus on two different growth regimes, the former, posits that growth is profit-led and the latter that growth is wage-led. Both are not ‘zero sum’ processes and seem to offer the same end result (growth and development). However, profit-led growth seems to have two problems. First, at least in the medium run, there is a trade-off between growth and income distribution. And secondly, profit-led growth is contradictory at the global level. Wage-led growth, which offers a ‘high road’ approach, seems far more appealing. Furthermore, several authors, including in South Africa, have claimed that regime-switching (to wage-led growth), is possible, and it seems that labour market institutions may play an important role in facilitating such a switch. However, the empirical literature, especially regarding middle- and low-income countries, is sparse and inconclusive. The panel data analysis provided by this thesis was not conclusive in establishing whether the wage-led, high road path is still viable for countries like South Africa. However, it did not find strong evidence of the contrary. The thesis concluded that there is scope for further research in this field and makes certain suggestions in this regard. , Thesis (MCom) -- Faculty of Commerce, Economics and Economic History, 2022
- Full Text:
- Date Issued: 2022-10-14
In vitro pharmacological screening of thiazolidinedione-derivatives on diabetes and Alzheimer’s potential therapeutic targets
- Authors: Arineitwe, Charles
- Date: 2022-10-14
- Subjects: Diabetes Treatment , Alzheimer's disease Treatment , Antioxidants Therapeutic use , Rosiglitazone , Hypoglycemic agents , In vitro screening , Thiazolidinedione Derivatives
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/232171 , vital:49968
- Description: There is an increased prevalence of diabetes and other non-communicable diseases in Sub-Saharan Africa and globally. In South Africa, the prevalence of type 2 Diabetes mellitus is currently estimated at 9.0% in people aged 30 and older and is expected to increase. Diabetes-related complications result in acute alterations in the mental state due to poor metabolic control as well as greater rates of decline in cognitive functioning with age, higher prevalence of depression and increased risk of Alzheimer’s disease. Alzheimer’s disease is the most common form of dementia in older adults and possibly contributes to 60 - 70% of cases. Alzheimer’s disease remains incurable, its progression inevitable with the currently available symptomatic therapies being palliative while the treatment of diabetes relies on insulin preparations and other glucose-lowering agents. Current treatment options have numerous side effects such as hypoglycaemia, diarrhoea, weight gain and abnormal liver function. This has geared the investigation of new generations of small molecules which exhibit improved efficacy and safety profiles. On this basis, several studies have shown that thiazolidinediones and their corresponding derivatives exhibit a broad spectrum of biological activities including anti-inflammatory, and antioxidant activities. Furthermore, recent evidence from experimental, epidemiological, and clinical studies highlight the utility of antioxidants for treating diabetes and its complications. Interestingly, there is increasing evidence that links diabetes and Alzheimer’s disease due to their pathophysiology and suppressing glycaemia has been shown to be beneficial in Alzheimer’s disease treatment. Accordingly, the aim of this study, was to evaluate the anti-diabetic and anti-Alzheimer’s properties of four novel synthesized thiazolidinedione-derivatives owing to their antioxidant properties. Methods The aim of this study was achieved through performing ferric reducing antioxidant power activity, 2,2’-Diphenyl-1-Picry Hydrazyl radical scavenging activity, α-amylase inhibition, α-glucosidase inhibition, aldose reductase inhibition, protein tyrosine phosphatase-1B inhibition, dipeptidyl peptidase-4 inhibition, acetylcholinesterase inhibition, matrix metalloproteinase-1 inhibition, and β-amyloid aggregation inhibition assays. In addition, peroxisome proliferator-activated receptor-γ activation was performed through docking studies. To establish physicochemical properties of TZD derivatives investigated, further in-silico studies were done using SwissADME tools. Results To this end, in-vitro and in-silico studies were successfully performed. In-silico ADME profiling predicted these derivatives to be drug-like with moderate to good solubility in the GI and not blood-brain barrier permeable. Furthermore, docking of these molecules against PPARγ predicted a similar mode of action to that of thiazolidinediones using Rosiglitazone as the standard drug with TZDD2 and TZDD4 forming equivalent conformations to that of Rosiglitazone in the same binding site and TZDD3 having an equivalent LBE to that of Rosiglitazone (-8.84 and -8.63kcal/mol respectively). In-vitro evaluation predicted a moderate antioxidant activity with TZDD2 and 3 exhibiting the highest FRAP activity and DPPH radical scavenging activity. Furthermore, enzymatic inhibition assays showed a relative inhibition activity with TZDD3 exhibited > 100% inhibition in concentrations ≥ 30 μg/mL and TZDD1, 2 and 4 exhibited ≥ 50% inhibition activity in all the concentrations (10, 20, 30, 40 and 50 μg/mL) in the α-amylase inhibition assay. Similarly, in the α-glucosidase inhibition assay, all the four derivatives exhibited a concentration dependent activity with TZDD3 showing the most activity. All the four derivatives exhibited ≥ 30% inhibition in the aldose reductase inhibition assay except TZDD1 at 10 μg/mL. TZDD4 exhibited a concentration dependent inhibition activity in the protein tyrosine phosphatase-1B inhibition assay. Interestingly, TZDD3 showed a decreasing inhibition activity as its concentration increased from 10 μg/mL through to 50 μg/mL. In the dipeptidyl peptidase–4 inhibition assay, TZDD2 and TZDD4 exhibited ≥ 20% inhibition activity across all the concentrations and in the acetylcholinesterase assay, TZDD1, 3 and 4 exhibited ≥ 25% across all the concentrations. Interestingly, in the matrix metalloproteinase-1 inhibition assay, some of these derivatives exhibited partial activation activity and partial inhibition with TZDD1 showing activation in concentrations 10 and 20 μg/mL and inhibition in concentrations 30, 40 and 50 μg/mL. TZDD4 showed activation in all the concentrations. In the β-amyloid aggregation assay, all the four derivatives showed inhibition activity ≥ 10% except TZDD1 at 50 μg/mL. Conclusions Diabetes mellitus and Alzheimer’s disease are a type of pathology of global concern, and several researchers worldwide have strived to search for novel therapeutic treatments and prevention for diabetes as well as Alzheimer’s disease. Recent studies provide a direct link v between diabetes mellitus and Alzheimer’s disease, and the need to find novel drugs that can mitigate these two is of increasing interest. In our search for antidiabetic and anti-Alzheimer’s activity, TZD derivatives (TZDD1, TZDD2, TZDD3 and TZDD4) exhibited good antioxidant activity, anti-hyperglycaemic activity and a relatively promising anti-Alzheimer’s activity. This was observed from the in vitro evaluation performed which included α – amylase, α – glucosidase, aldose reductase, PTP1B, DPP4, amyloid β aggregation, and AChE inhibition assays. Furthermore, docking of the derivatives against PPARγ predicted a similar molecular interaction to that of thiazolidinediones using Rosiglitazone as the standard drug. Furthermore, in silico ADME profiling predicted the derivatives to have moderate to good solubility in the GI (good GI bioavailability), and also exhibited excellent drug likeness. However, they are predicted not permeate the BBB. Further in silico studies and in vivo should be conducted to establish toxicities, as well as drug delivery to the brain for effective therapeutic effect against Alzheimer’s disease. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacology, 2022
- Full Text: false
- Date Issued: 2022-10-14
- Authors: Arineitwe, Charles
- Date: 2022-10-14
- Subjects: Diabetes Treatment , Alzheimer's disease Treatment , Antioxidants Therapeutic use , Rosiglitazone , Hypoglycemic agents , In vitro screening , Thiazolidinedione Derivatives
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/232171 , vital:49968
- Description: There is an increased prevalence of diabetes and other non-communicable diseases in Sub-Saharan Africa and globally. In South Africa, the prevalence of type 2 Diabetes mellitus is currently estimated at 9.0% in people aged 30 and older and is expected to increase. Diabetes-related complications result in acute alterations in the mental state due to poor metabolic control as well as greater rates of decline in cognitive functioning with age, higher prevalence of depression and increased risk of Alzheimer’s disease. Alzheimer’s disease is the most common form of dementia in older adults and possibly contributes to 60 - 70% of cases. Alzheimer’s disease remains incurable, its progression inevitable with the currently available symptomatic therapies being palliative while the treatment of diabetes relies on insulin preparations and other glucose-lowering agents. Current treatment options have numerous side effects such as hypoglycaemia, diarrhoea, weight gain and abnormal liver function. This has geared the investigation of new generations of small molecules which exhibit improved efficacy and safety profiles. On this basis, several studies have shown that thiazolidinediones and their corresponding derivatives exhibit a broad spectrum of biological activities including anti-inflammatory, and antioxidant activities. Furthermore, recent evidence from experimental, epidemiological, and clinical studies highlight the utility of antioxidants for treating diabetes and its complications. Interestingly, there is increasing evidence that links diabetes and Alzheimer’s disease due to their pathophysiology and suppressing glycaemia has been shown to be beneficial in Alzheimer’s disease treatment. Accordingly, the aim of this study, was to evaluate the anti-diabetic and anti-Alzheimer’s properties of four novel synthesized thiazolidinedione-derivatives owing to their antioxidant properties. Methods The aim of this study was achieved through performing ferric reducing antioxidant power activity, 2,2’-Diphenyl-1-Picry Hydrazyl radical scavenging activity, α-amylase inhibition, α-glucosidase inhibition, aldose reductase inhibition, protein tyrosine phosphatase-1B inhibition, dipeptidyl peptidase-4 inhibition, acetylcholinesterase inhibition, matrix metalloproteinase-1 inhibition, and β-amyloid aggregation inhibition assays. In addition, peroxisome proliferator-activated receptor-γ activation was performed through docking studies. To establish physicochemical properties of TZD derivatives investigated, further in-silico studies were done using SwissADME tools. Results To this end, in-vitro and in-silico studies were successfully performed. In-silico ADME profiling predicted these derivatives to be drug-like with moderate to good solubility in the GI and not blood-brain barrier permeable. Furthermore, docking of these molecules against PPARγ predicted a similar mode of action to that of thiazolidinediones using Rosiglitazone as the standard drug with TZDD2 and TZDD4 forming equivalent conformations to that of Rosiglitazone in the same binding site and TZDD3 having an equivalent LBE to that of Rosiglitazone (-8.84 and -8.63kcal/mol respectively). In-vitro evaluation predicted a moderate antioxidant activity with TZDD2 and 3 exhibiting the highest FRAP activity and DPPH radical scavenging activity. Furthermore, enzymatic inhibition assays showed a relative inhibition activity with TZDD3 exhibited > 100% inhibition in concentrations ≥ 30 μg/mL and TZDD1, 2 and 4 exhibited ≥ 50% inhibition activity in all the concentrations (10, 20, 30, 40 and 50 μg/mL) in the α-amylase inhibition assay. Similarly, in the α-glucosidase inhibition assay, all the four derivatives exhibited a concentration dependent activity with TZDD3 showing the most activity. All the four derivatives exhibited ≥ 30% inhibition in the aldose reductase inhibition assay except TZDD1 at 10 μg/mL. TZDD4 exhibited a concentration dependent inhibition activity in the protein tyrosine phosphatase-1B inhibition assay. Interestingly, TZDD3 showed a decreasing inhibition activity as its concentration increased from 10 μg/mL through to 50 μg/mL. In the dipeptidyl peptidase–4 inhibition assay, TZDD2 and TZDD4 exhibited ≥ 20% inhibition activity across all the concentrations and in the acetylcholinesterase assay, TZDD1, 3 and 4 exhibited ≥ 25% across all the concentrations. Interestingly, in the matrix metalloproteinase-1 inhibition assay, some of these derivatives exhibited partial activation activity and partial inhibition with TZDD1 showing activation in concentrations 10 and 20 μg/mL and inhibition in concentrations 30, 40 and 50 μg/mL. TZDD4 showed activation in all the concentrations. In the β-amyloid aggregation assay, all the four derivatives showed inhibition activity ≥ 10% except TZDD1 at 50 μg/mL. Conclusions Diabetes mellitus and Alzheimer’s disease are a type of pathology of global concern, and several researchers worldwide have strived to search for novel therapeutic treatments and prevention for diabetes as well as Alzheimer’s disease. Recent studies provide a direct link v between diabetes mellitus and Alzheimer’s disease, and the need to find novel drugs that can mitigate these two is of increasing interest. In our search for antidiabetic and anti-Alzheimer’s activity, TZD derivatives (TZDD1, TZDD2, TZDD3 and TZDD4) exhibited good antioxidant activity, anti-hyperglycaemic activity and a relatively promising anti-Alzheimer’s activity. This was observed from the in vitro evaluation performed which included α – amylase, α – glucosidase, aldose reductase, PTP1B, DPP4, amyloid β aggregation, and AChE inhibition assays. Furthermore, docking of the derivatives against PPARγ predicted a similar molecular interaction to that of thiazolidinediones using Rosiglitazone as the standard drug. Furthermore, in silico ADME profiling predicted the derivatives to have moderate to good solubility in the GI (good GI bioavailability), and also exhibited excellent drug likeness. However, they are predicted not permeate the BBB. Further in silico studies and in vivo should be conducted to establish toxicities, as well as drug delivery to the brain for effective therapeutic effect against Alzheimer’s disease. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacology, 2022
- Full Text: false
- Date Issued: 2022-10-14
A multispectral and machine learning approach to early stress classification in plants
- Authors: Poole, Louise Carmen
- Date: 2022-04-06
- Subjects: Machine learning , Neural networks (Computer science) , Multispectral imaging , Image processing , Plant stress detection
- Language: English
- Type: Master's thesis , text
- Identifier: http://hdl.handle.net/10962/232410 , vital:49989
- Description: Crop loss and failure can impact both a country’s economy and food security, often to devastating effects. As such, the importance of successfully detecting plant stresses early in their development is essential to minimize spread and damage to crop production. Identification of the stress and the stress-causing agent is the most critical and challenging step in plant and crop protection. With the development of and increase in ease of access to new equipment and technology in recent years, the use of spectroscopy in the early detection of plant diseases has become notably popular. This thesis narrows down the most suitable multispectral imaging techniques and machine learning algorithms for early stress detection. Datasets were collected of visible images and multispectral images. Dehydration was selected as the plant stress type for the main experiments, and data was collected from six plant species typically used in agriculture. Key contributions of this thesis include multispectral and visible datasets showing plant dehydration as well as a separate preliminary dataset on plant disease. Promising results on dehydration showed statistically significant accuracy improvements in the multispectral imaging compared to visible imaging for early stress detection, with multispectral input obtaining a 92.50% accuracy over visible input’s 77.50% on general plant species. The system was effective at stress detection on known plant species, with multispectral imaging introducing greater improvement to early stress detection than advanced stress detection. Furthermore, strong species discrimination was achieved when exclusively testing either early or advanced dehydration against healthy species. , Thesis (MSc) -- Faculty of Science, Ichthyology & Fisheries Sciences, 2022
- Full Text:
- Date Issued: 2022-04-06
- Authors: Poole, Louise Carmen
- Date: 2022-04-06
- Subjects: Machine learning , Neural networks (Computer science) , Multispectral imaging , Image processing , Plant stress detection
- Language: English
- Type: Master's thesis , text
- Identifier: http://hdl.handle.net/10962/232410 , vital:49989
- Description: Crop loss and failure can impact both a country’s economy and food security, often to devastating effects. As such, the importance of successfully detecting plant stresses early in their development is essential to minimize spread and damage to crop production. Identification of the stress and the stress-causing agent is the most critical and challenging step in plant and crop protection. With the development of and increase in ease of access to new equipment and technology in recent years, the use of spectroscopy in the early detection of plant diseases has become notably popular. This thesis narrows down the most suitable multispectral imaging techniques and machine learning algorithms for early stress detection. Datasets were collected of visible images and multispectral images. Dehydration was selected as the plant stress type for the main experiments, and data was collected from six plant species typically used in agriculture. Key contributions of this thesis include multispectral and visible datasets showing plant dehydration as well as a separate preliminary dataset on plant disease. Promising results on dehydration showed statistically significant accuracy improvements in the multispectral imaging compared to visible imaging for early stress detection, with multispectral input obtaining a 92.50% accuracy over visible input’s 77.50% on general plant species. The system was effective at stress detection on known plant species, with multispectral imaging introducing greater improvement to early stress detection than advanced stress detection. Furthermore, strong species discrimination was achieved when exclusively testing either early or advanced dehydration against healthy species. , Thesis (MSc) -- Faculty of Science, Ichthyology & Fisheries Sciences, 2022
- Full Text:
- Date Issued: 2022-04-06
Household food waste generation, disposal and minimisation in two South African towns
- Authors: Mtakati, Sinako
- Date: 2022-04
- Subjects: Food waste South Africa Cradock , Food waste South Africa Middelburg (Eastern Cape) , Sanitary landfills Environmental aspects South Africa , Greenhouse gases Environmental aspects South Africa , Income distribution South Africa , Socio-economic status South Africa , Waste minimization South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/232159 , vital:49967
- Description: Food waste is becoming an important issue considering greenhouse gas emissions from landfills. However, data on the quantities of food disposed remains limited, especially for developing, countries including South Africa. Global food waste estimates suggest that households in developed countries waste more food than those in developing countries. Further, research shows that lack of food waste management impacts negatively on the global efforts to combat food waste generation. I therefore set out to present primary data relating to household food waste generation and minimisation within a South African context. The case study covers two towns in the Eastern Cape province, namely Cradock and Middelburg, with a combined population of 55 352 people. Household food waste assessment and quantification was undertaken using two methods, 1) questionnaires to explore quantities of different types of food wasted by households, and 2) kitchen scales to measure the amounts of food discarded by households. Participating households in each suburb were selected randomly. Differences in shopping and household food waste behaviour in households from different income suburbs is vital to understand as it sets an effective approach to food waste interventions that might have a positive impact in minimising food waste generation. In this thesis, differences in shopping and household food waste behaviour across households in the affluent, middle and low-income suburbs is uncovered. A questionnaire was conducted and households in the affluent suburbs purchased food more frequently and had the highest percentage of respondents that used shopping list when buying food than those in the middle and low-income suburbs. The thesis also indicates that households in the low-income suburbs were more attracted to food special offers and had a higher proportion of respondents who could not distinguish between “Use by” and “Best before” dates than those in the affluent and middle- income suburbs. The reasons to food waste generation overlap between the towns. However, between the suburbs, the respondents from households in the affluent suburbs pointed that they were mainly generating and disposing food waste because they did not think it is an issue. Excessive cooking and food expiring before being consumed were found to be the most common reasons for food waste generation and disposal among households in the low and middle-income suburbs. The times which households are likely to generate more food waste were investigated. Nonetheless, only a few households indicated that there were times that they generated and disposed more food in the bins. The most cited times in the affluent suburbs were during Christmas (54%) and in summer (41%). Festive season (65%) and traditional ceremonies (37%) were the most cited times in the middle-income suburbs, while festive season (46%) and the summer season (36%) were the most cites among households in the low- income suburbs. The dimensions of shopping and household food waste behaviour is reflected in the types and quantities of food waste generated. The results reveal that vegetables were the most wasted food type in Cradock (26%) and in Middelburg (30%), while tinned food and dairy were the least discarded food types in both study towns with no significant differences in proportions of households discarding all six food types. One of the key results is that the average self-reported and weighed food waste generated per capita per annum for the two towns was 23.40±47.20 and 202.60±128.30 kg/capita/year, respectively as compared to the estimated 6-11 kg per annum in sub-Saharan Africa and South and Southeast Asia. Between the towns, Cradock generated more food waste (5.05±2.68 kg) than those in Middleburg (3.84±2.59 kg) in the previous 48 hours. It was also evident that each household and each person in Cradock generated more food waste at breakfast and the least at lunch, while in Middelburg the highest average amount of food waste generated was observed at supper and the least at lunch. The results indicate that household size and employment status were negatively correlated to food waste generation, while wealth status and gender were positively correlated to food waste generation. Majority of households (74% in Cradock and 73% in Middelburg) had no household food waste minimisation strategies implemented. The most cited strategies in place were cooking less frequently, cooking small portions and chopping and freezing vegetables as an anti-food waste strategy. Worth noting is that the small proportion of households with strategies in place are faced with a challenge of some household members showing unwillingness to effectively implement the strategies. The results also reveal that children wasted more food than adults, particularly girls. , Thesis (MSc) -- Faculty of Science, Environmental Science, 2022
- Full Text:
- Date Issued: 2022-04
- Authors: Mtakati, Sinako
- Date: 2022-04
- Subjects: Food waste South Africa Cradock , Food waste South Africa Middelburg (Eastern Cape) , Sanitary landfills Environmental aspects South Africa , Greenhouse gases Environmental aspects South Africa , Income distribution South Africa , Socio-economic status South Africa , Waste minimization South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/232159 , vital:49967
- Description: Food waste is becoming an important issue considering greenhouse gas emissions from landfills. However, data on the quantities of food disposed remains limited, especially for developing, countries including South Africa. Global food waste estimates suggest that households in developed countries waste more food than those in developing countries. Further, research shows that lack of food waste management impacts negatively on the global efforts to combat food waste generation. I therefore set out to present primary data relating to household food waste generation and minimisation within a South African context. The case study covers two towns in the Eastern Cape province, namely Cradock and Middelburg, with a combined population of 55 352 people. Household food waste assessment and quantification was undertaken using two methods, 1) questionnaires to explore quantities of different types of food wasted by households, and 2) kitchen scales to measure the amounts of food discarded by households. Participating households in each suburb were selected randomly. Differences in shopping and household food waste behaviour in households from different income suburbs is vital to understand as it sets an effective approach to food waste interventions that might have a positive impact in minimising food waste generation. In this thesis, differences in shopping and household food waste behaviour across households in the affluent, middle and low-income suburbs is uncovered. A questionnaire was conducted and households in the affluent suburbs purchased food more frequently and had the highest percentage of respondents that used shopping list when buying food than those in the middle and low-income suburbs. The thesis also indicates that households in the low-income suburbs were more attracted to food special offers and had a higher proportion of respondents who could not distinguish between “Use by” and “Best before” dates than those in the affluent and middle- income suburbs. The reasons to food waste generation overlap between the towns. However, between the suburbs, the respondents from households in the affluent suburbs pointed that they were mainly generating and disposing food waste because they did not think it is an issue. Excessive cooking and food expiring before being consumed were found to be the most common reasons for food waste generation and disposal among households in the low and middle-income suburbs. The times which households are likely to generate more food waste were investigated. Nonetheless, only a few households indicated that there were times that they generated and disposed more food in the bins. The most cited times in the affluent suburbs were during Christmas (54%) and in summer (41%). Festive season (65%) and traditional ceremonies (37%) were the most cited times in the middle-income suburbs, while festive season (46%) and the summer season (36%) were the most cites among households in the low- income suburbs. The dimensions of shopping and household food waste behaviour is reflected in the types and quantities of food waste generated. The results reveal that vegetables were the most wasted food type in Cradock (26%) and in Middelburg (30%), while tinned food and dairy were the least discarded food types in both study towns with no significant differences in proportions of households discarding all six food types. One of the key results is that the average self-reported and weighed food waste generated per capita per annum for the two towns was 23.40±47.20 and 202.60±128.30 kg/capita/year, respectively as compared to the estimated 6-11 kg per annum in sub-Saharan Africa and South and Southeast Asia. Between the towns, Cradock generated more food waste (5.05±2.68 kg) than those in Middleburg (3.84±2.59 kg) in the previous 48 hours. It was also evident that each household and each person in Cradock generated more food waste at breakfast and the least at lunch, while in Middelburg the highest average amount of food waste generated was observed at supper and the least at lunch. The results indicate that household size and employment status were negatively correlated to food waste generation, while wealth status and gender were positively correlated to food waste generation. Majority of households (74% in Cradock and 73% in Middelburg) had no household food waste minimisation strategies implemented. The most cited strategies in place were cooking less frequently, cooking small portions and chopping and freezing vegetables as an anti-food waste strategy. Worth noting is that the small proportion of households with strategies in place are faced with a challenge of some household members showing unwillingness to effectively implement the strategies. The results also reveal that children wasted more food than adults, particularly girls. , Thesis (MSc) -- Faculty of Science, Environmental Science, 2022
- Full Text:
- Date Issued: 2022-04
The design of a regional Archives in Swellendam, South Africa
- Authors: Steyn, Anli
- Date: 2021-12
- Subjects: Archival materials -- Conservation and restoration -- Construction , Community centers -- South Africa -- Swellendam -- Designs and plans
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/58595 , vital:59944
- Description: The treatise and proposed project deal with the creation of spaces rooted in the culture of a place, its identity, memory and meaning in the form of a contemporary regional archive and museum space for the context of Swellendam’s historical ribbon. The treatise seeks to find a strategy for a contemporary, yet regional specific, intervention in a traditional context and attempts to fulfil the creation of a place of culture, identity, meaning and memory. The methodology used for this architectural treatise is qualitative. In order to establish an appropriate building type, Swellendam's history and contextual data were analysed, at the same time, selected literature and ideas were introduced to establish the project's value set. Methods and principles are extracted and reinterpreted by the design project. Among the various works of literatures/theories reviewed in this treatise is that of Jonathan Noble, Maurice Halbwach, and Kenneth Frampton, among others. This respective literature sets the basis of the project’s value set on place and identity, memory and meaning, and tectonics and materials. The town’s rich history, morphology and nature of physical context are selected as an appropriate site. Furthermore, the treatise explores museums and archives as building types. This is done through the comparison of precedents under the light of certain issues. From this, the building type’s activities and spatial, programmatical requirements are gathered. Amid this various information collected are a set of relevant principles. Therefore, a set of principles (approach to memory, meaning and identity; heritage and conservation; extracting from the existing/vernacular/context; and approach to light) is explored and precedents are used to represent and learn from principles. This design project goes through a series of iterations to fulfil the specific architectural concerns and to create architecture specific for the context (relation to place, culture, history and site). The final design attempts to be a sensitive intervention, neutral in form, that resembles a heterogenous culture and hybridity. It aims to represent the culture of its place while being a public museum and archive facility. , Thesis (MArch) (Professional) -- Faculty of Engineering, the Built Environment and Technology, School of Architecture, 2021
- Full Text:
- Date Issued: 2021-12
- Authors: Steyn, Anli
- Date: 2021-12
- Subjects: Archival materials -- Conservation and restoration -- Construction , Community centers -- South Africa -- Swellendam -- Designs and plans
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/58595 , vital:59944
- Description: The treatise and proposed project deal with the creation of spaces rooted in the culture of a place, its identity, memory and meaning in the form of a contemporary regional archive and museum space for the context of Swellendam’s historical ribbon. The treatise seeks to find a strategy for a contemporary, yet regional specific, intervention in a traditional context and attempts to fulfil the creation of a place of culture, identity, meaning and memory. The methodology used for this architectural treatise is qualitative. In order to establish an appropriate building type, Swellendam's history and contextual data were analysed, at the same time, selected literature and ideas were introduced to establish the project's value set. Methods and principles are extracted and reinterpreted by the design project. Among the various works of literatures/theories reviewed in this treatise is that of Jonathan Noble, Maurice Halbwach, and Kenneth Frampton, among others. This respective literature sets the basis of the project’s value set on place and identity, memory and meaning, and tectonics and materials. The town’s rich history, morphology and nature of physical context are selected as an appropriate site. Furthermore, the treatise explores museums and archives as building types. This is done through the comparison of precedents under the light of certain issues. From this, the building type’s activities and spatial, programmatical requirements are gathered. Amid this various information collected are a set of relevant principles. Therefore, a set of principles (approach to memory, meaning and identity; heritage and conservation; extracting from the existing/vernacular/context; and approach to light) is explored and precedents are used to represent and learn from principles. This design project goes through a series of iterations to fulfil the specific architectural concerns and to create architecture specific for the context (relation to place, culture, history and site). The final design attempts to be a sensitive intervention, neutral in form, that resembles a heterogenous culture and hybridity. It aims to represent the culture of its place while being a public museum and archive facility. , Thesis (MArch) (Professional) -- Faculty of Engineering, the Built Environment and Technology, School of Architecture, 2021
- Full Text:
- Date Issued: 2021-12
Ubomi Sisilonda: Ingqokelela Yemibongo
- Authors: Yanta, Luvuyo Mkhululi
- Date: 2021-10-29
- Subjects: Creative writing (Higher education) South Africa , Xhosa poetry 21st century , Diaries -- Authorship , South African poetry (English) History and criticism , Xhosa poetry History and criticism , Poetry Therapeutic use
- Language: Xhosa , English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192364 , vital:45219
- Description: Esi siqingatha sethisisi yingqokelela yemibongo-ngoma eyilwe ngeenjongo zokuzama ukuveza nokupholisa isilonda esidalwe ziimeko zobom esiphila kubo singabantu, izinto endizibonileyo nendidlule kuzo. Ndibhala ndibonakalisa ubumnyama endiphile kubo, apha ndizama ukusondela ekukhanyeni. Ndiqala ngokupholisa ezam izilonda kuqala. Ulwimi endilusebenzisayo lulanda imbali yam njengomfana omnyama okhulele elokishini, ilokishi nganye inolwimi lwayo. Ndisebenzisa olu lwimi ndibalisa indlela endikhule ngayo, ndikwakhankanya nokukhula ndiqheliswa ukungathethi ngezinto nokungawavezi amanxeba entliziyo yam phambi kwabantu “ilayithi ayikhali.” Ndinomdla kubabhali ababhala ngeemeko zexesha lanamhlanje, kwiimeko eziphilwa luninzi lwabantu nesimo sentlalo jikelele. Ndisebenzise umsebenzi wababhali abafana noAyanda Billie ukujonga isingqi sobom kwimibongo yakhe njengomntu ongekho kude ngokuhlala nokufuphi ngeminyaka, ndiqwalasele imisebenzi kaS. Zotwana ukuzama ukusondeza isigama kwindlela endikhule ngayo kunye noJ.J.R Jolobe ukuqwalasela ukuba babesebenzisa obuphi ubuchule bokubhala nokupholisa izilonda zabo. Ndikwacaphule kwisimbo sokubhala esikhawulezileyo semibhalo eyenzelwe iqonga njengoko ndichithe ixesha elininzi ndidlala kwaye ndikwaqeqesha abadlali beqonga. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Yanta, Luvuyo Mkhululi
- Date: 2021-10-29
- Subjects: Creative writing (Higher education) South Africa , Xhosa poetry 21st century , Diaries -- Authorship , South African poetry (English) History and criticism , Xhosa poetry History and criticism , Poetry Therapeutic use
- Language: Xhosa , English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192364 , vital:45219
- Description: Esi siqingatha sethisisi yingqokelela yemibongo-ngoma eyilwe ngeenjongo zokuzama ukuveza nokupholisa isilonda esidalwe ziimeko zobom esiphila kubo singabantu, izinto endizibonileyo nendidlule kuzo. Ndibhala ndibonakalisa ubumnyama endiphile kubo, apha ndizama ukusondela ekukhanyeni. Ndiqala ngokupholisa ezam izilonda kuqala. Ulwimi endilusebenzisayo lulanda imbali yam njengomfana omnyama okhulele elokishini, ilokishi nganye inolwimi lwayo. Ndisebenzisa olu lwimi ndibalisa indlela endikhule ngayo, ndikwakhankanya nokukhula ndiqheliswa ukungathethi ngezinto nokungawavezi amanxeba entliziyo yam phambi kwabantu “ilayithi ayikhali.” Ndinomdla kubabhali ababhala ngeemeko zexesha lanamhlanje, kwiimeko eziphilwa luninzi lwabantu nesimo sentlalo jikelele. Ndisebenzise umsebenzi wababhali abafana noAyanda Billie ukujonga isingqi sobom kwimibongo yakhe njengomntu ongekho kude ngokuhlala nokufuphi ngeminyaka, ndiqwalasele imisebenzi kaS. Zotwana ukuzama ukusondeza isigama kwindlela endikhule ngayo kunye noJ.J.R Jolobe ukuqwalasela ukuba babesebenzisa obuphi ubuchule bokubhala nokupholisa izilonda zabo. Ndikwacaphule kwisimbo sokubhala esikhawulezileyo semibhalo eyenzelwe iqonga njengoko ndichithe ixesha elininzi ndidlala kwaye ndikwaqeqesha abadlali beqonga. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
- Full Text:
- Date Issued: 2021-10-29
Knowledge and attitude towards mastitis, culling and mortality among dairy farmworkers, and factors associated with culling and mortality among dairy cattle in the Eastern Cape Province, South Africa
- Authors: Diniso, Yanga Simamkele
- Date: 2021-09
- Subjects: Food security , Dairying--Economic aspects , Milking
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/20686 , vital:46425
- Description: Globally, food security is under threat from escalating population growth, new variants of diseases, climate change and livestock loss. Africa is vulnerable to food insecurity, with majority of the estimated 800 million suffering from hunger based in Africa. Intensification of production is a common strategy to counter the increasing demand for nutritional food to maintain and improve food security. The dairy industry is one of the leading agriculture sectors that has adopted intensification of production. The current study had two specific objectives; the first objective was to evaluate the dairy farmworkers’ knowledge and attitude towards mastitis, culling, and mortality in the southern part of the Eastern Cape Province. The data was collected from 106 dairy farm workers of different farm hierarchy in 5 out of 6 districts using questionnaire. In cases whereby a majority correctly answered a question, a point was awarded and a zero for incorrectly answered questions by the majority. A less than 50 percent pass rate was considered a poor level of knowledge, 51-69 percent pass rate was considered an average level of knowledge, and anything higher than that considered a good level of knowledge. The majority of the participants (64.2 percent) indicated that they consume unpasteurised milk even though they know its risks. There was no association (P>0.05) between workplace position, educational level, work experience, and consumption of unpasteurised milk. This study found that participants had a deficient level of knowledge of mastitis causing pathogens by attaining a pass mark of 1.60 out of a possible 10 (16 percent), and educational level was significantly associated with knowledge of Escherichia coli, Staphylococcus aureus, and Streptococcus spp. However, the participants (64.9 percent) showed good knowledge of clinical signs of mastitis, and this was attributed to the regular mastitis detection with California Mastitis Test (CMT, 60.4 percent) and a strip cup (83.0 percent). The participants had varying perceptions and limited knowledge (28.3 percent pass rate) about the major contributing factors of culling and mortality. The lack of dairy training courses and minimal use of other sources of information such as the internet might contribute to this poor knowledge and perceptions. The second objective involved identifying and describing the factors responsible for culling and mortality in dairy farms in the Eastern Cape province, South Africa. The factors were grouped into seven (7) major factors namely lameness and poor growth (2.33 percent), reproduction problems (35.86 percent), health factors (6.72 percent), production factors (7.11 percent), udder-related factors (3.42 percent), voluntary culls (4.86 percent) and miscellaneous factors (26.03 percent). The most frequent reason for culling dairy cows was reproduction problems which was mainly made up of infertility (7.9 percent), reproductive failure (89.9 percent), and dystocia (1 percent). Miscellaneous factors which mainly consisted of indigenous breeds (8.2 percent), and age (2.7 percent) accounted for the second most prevalent factors for the culling of dairy cows. All the farms recorded stock-theft as part of involuntary culling and accounted for 3.6 percent dairy cows that were culled. Poor milk yield and health-related factors such as red-water (33.8 percent), milk-fever (23.3 percent), and heart-water (6.8 percent) were amongst the major factors responsible for the culling of dairy cows. There were 1774 (13.67 percent) dairy cows that died in the study farms from 2015 to 2019 and causes of death were not specified except for drowning (0.01 percent) and snake bite (1 percent). This study exposed a gap in knowledge about the causes of mastitis, culling and mortality among dairy farmworkers in the southern part of the Eastern Cape Province. Furthermore, this study provided with a baseline information on the leading causes of culling and mortality. There is a need for further research on strategies of enhancing the knowledge of dairy farmworkers about pathogens of mastitis and specific causes of culling and mortality to mitigate the challenge they pose to food security. , Thesis (MSc) (Animal Science) -- University of Fort Hare, 2021
- Full Text:
- Date Issued: 2021-09
- Authors: Diniso, Yanga Simamkele
- Date: 2021-09
- Subjects: Food security , Dairying--Economic aspects , Milking
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/20686 , vital:46425
- Description: Globally, food security is under threat from escalating population growth, new variants of diseases, climate change and livestock loss. Africa is vulnerable to food insecurity, with majority of the estimated 800 million suffering from hunger based in Africa. Intensification of production is a common strategy to counter the increasing demand for nutritional food to maintain and improve food security. The dairy industry is one of the leading agriculture sectors that has adopted intensification of production. The current study had two specific objectives; the first objective was to evaluate the dairy farmworkers’ knowledge and attitude towards mastitis, culling, and mortality in the southern part of the Eastern Cape Province. The data was collected from 106 dairy farm workers of different farm hierarchy in 5 out of 6 districts using questionnaire. In cases whereby a majority correctly answered a question, a point was awarded and a zero for incorrectly answered questions by the majority. A less than 50 percent pass rate was considered a poor level of knowledge, 51-69 percent pass rate was considered an average level of knowledge, and anything higher than that considered a good level of knowledge. The majority of the participants (64.2 percent) indicated that they consume unpasteurised milk even though they know its risks. There was no association (P>0.05) between workplace position, educational level, work experience, and consumption of unpasteurised milk. This study found that participants had a deficient level of knowledge of mastitis causing pathogens by attaining a pass mark of 1.60 out of a possible 10 (16 percent), and educational level was significantly associated with knowledge of Escherichia coli, Staphylococcus aureus, and Streptococcus spp. However, the participants (64.9 percent) showed good knowledge of clinical signs of mastitis, and this was attributed to the regular mastitis detection with California Mastitis Test (CMT, 60.4 percent) and a strip cup (83.0 percent). The participants had varying perceptions and limited knowledge (28.3 percent pass rate) about the major contributing factors of culling and mortality. The lack of dairy training courses and minimal use of other sources of information such as the internet might contribute to this poor knowledge and perceptions. The second objective involved identifying and describing the factors responsible for culling and mortality in dairy farms in the Eastern Cape province, South Africa. The factors were grouped into seven (7) major factors namely lameness and poor growth (2.33 percent), reproduction problems (35.86 percent), health factors (6.72 percent), production factors (7.11 percent), udder-related factors (3.42 percent), voluntary culls (4.86 percent) and miscellaneous factors (26.03 percent). The most frequent reason for culling dairy cows was reproduction problems which was mainly made up of infertility (7.9 percent), reproductive failure (89.9 percent), and dystocia (1 percent). Miscellaneous factors which mainly consisted of indigenous breeds (8.2 percent), and age (2.7 percent) accounted for the second most prevalent factors for the culling of dairy cows. All the farms recorded stock-theft as part of involuntary culling and accounted for 3.6 percent dairy cows that were culled. Poor milk yield and health-related factors such as red-water (33.8 percent), milk-fever (23.3 percent), and heart-water (6.8 percent) were amongst the major factors responsible for the culling of dairy cows. There were 1774 (13.67 percent) dairy cows that died in the study farms from 2015 to 2019 and causes of death were not specified except for drowning (0.01 percent) and snake bite (1 percent). This study exposed a gap in knowledge about the causes of mastitis, culling and mortality among dairy farmworkers in the southern part of the Eastern Cape Province. Furthermore, this study provided with a baseline information on the leading causes of culling and mortality. There is a need for further research on strategies of enhancing the knowledge of dairy farmworkers about pathogens of mastitis and specific causes of culling and mortality to mitigate the challenge they pose to food security. , Thesis (MSc) (Animal Science) -- University of Fort Hare, 2021
- Full Text:
- Date Issued: 2021-09
Nurse educators’ understanding of Africanising undergraduate education at a nursing education institution
- Authors: Mlatsha, Ayanda
- Date: 2021-04
- Subjects: Nursing --South Africa , Organizational Change -- Education , Educational change--South Africa --Nursing
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60764 , vital:67197
- Description: In the light of transformation and the need for a relatively recently liberated country to enhance higher education, one of the foremost demands of South Africans in education was that of Africanising higher education. Africanising is associated with the term ‘transformation’. The latter is a process that requires the revision of the existing education system towards that of an African-contextualised education system in Africa. Concurrently the nursing profession has an increased need for transcultural nursing in education to ensure that undergraduates deliver culturally aligned and African contextualised nursing care. At present, there is no clear description of how Africanising nursing education can be carried out by nurse educators. Hence some educators argue that the change may not be a smooth process as there is no blueprint that provides guidance for how the process should be conducted. This study intended to assist in describing the meaning of Africanising nursing education as it is understood by nurse educators in a Nursing Education Institution (NEI). Therefore, this study explored and described nurse educators’ understanding of Africanising undergraduate nursing education at a NEI in the Nelson Mandela Bay in the Eastern Cape, South Africa in order to construct recommendations for NEI managers and nurse educators on how the process of Africanising undergraduate nursing education at NEIs can be facilitated. The researcher used a qualitative descriptive approach. The postcolonial theory was used to underpin this study. Purposive sampling was utilised to select nurse educators for participation in the study. Each of the twelve participants were asked to draw a naïve sketch regarding their understanding of fricanisation of the undergraduate nursing education followed by an individual semi-structured interview. Data collection was conducted online, using recorded Zoom sessions. Content analysis was used to aanalyse the data and the findings were used to construct recommendations for NEI managers and nurse educators on how the process of Africanising undergraduate nursing education at NEIs can be enhanced. Throughout the study ethical principles as well as the requirements related to the concepts of trustworthiness, credibility; dependability; confirmability and transferability were upheld. , Thesis (MSc) -- Faculty of Health Sciences, School of Clinical care and Medicinal Sciences, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Mlatsha, Ayanda
- Date: 2021-04
- Subjects: Nursing --South Africa , Organizational Change -- Education , Educational change--South Africa --Nursing
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60764 , vital:67197
- Description: In the light of transformation and the need for a relatively recently liberated country to enhance higher education, one of the foremost demands of South Africans in education was that of Africanising higher education. Africanising is associated with the term ‘transformation’. The latter is a process that requires the revision of the existing education system towards that of an African-contextualised education system in Africa. Concurrently the nursing profession has an increased need for transcultural nursing in education to ensure that undergraduates deliver culturally aligned and African contextualised nursing care. At present, there is no clear description of how Africanising nursing education can be carried out by nurse educators. Hence some educators argue that the change may not be a smooth process as there is no blueprint that provides guidance for how the process should be conducted. This study intended to assist in describing the meaning of Africanising nursing education as it is understood by nurse educators in a Nursing Education Institution (NEI). Therefore, this study explored and described nurse educators’ understanding of Africanising undergraduate nursing education at a NEI in the Nelson Mandela Bay in the Eastern Cape, South Africa in order to construct recommendations for NEI managers and nurse educators on how the process of Africanising undergraduate nursing education at NEIs can be facilitated. The researcher used a qualitative descriptive approach. The postcolonial theory was used to underpin this study. Purposive sampling was utilised to select nurse educators for participation in the study. Each of the twelve participants were asked to draw a naïve sketch regarding their understanding of fricanisation of the undergraduate nursing education followed by an individual semi-structured interview. Data collection was conducted online, using recorded Zoom sessions. Content analysis was used to aanalyse the data and the findings were used to construct recommendations for NEI managers and nurse educators on how the process of Africanising undergraduate nursing education at NEIs can be enhanced. Throughout the study ethical principles as well as the requirements related to the concepts of trustworthiness, credibility; dependability; confirmability and transferability were upheld. , Thesis (MSc) -- Faculty of Health Sciences, School of Clinical care and Medicinal Sciences, 2021
- Full Text:
- Date Issued: 2021-04
Comparison between Endothelin, Nitric Oxide and their Association to Blood Pressure and Body Composition in HIV Patients, in Mthatha
- Authors: Zono, Sinethemba
- Date: 2015
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/11260/2909 , vital:43105
- Description: Background: Dysfunction of the vascular endothelium is an early finding in the progression of cardiovascular disease and is closely related to clinical events in patients with obesity and hypertension. Vascular function is mediated by nitric oxide (NO) and endothelin (ET-1) which serve as natural counterparts. The aim of the study was to determine the physiological effects of HIV infection, blood pressure and body composition on the changes of ET-1 and NO and association between ET-1 and NO. Methods and results: This was a descriptive and comparative study. A Quota sample method was used. The study population consisted of 154 participants categorized into the following groups: 57 HIV negative participants (A), 40 HIV positive not on treatment participants and 57 HIV positive on treatment participants. Enzyme immunoassay kit was used for the quantitative determination of ET-1 and Nitrate/nitrite colorimetric assay kit was used for the determination of NO. Anthropometric measurements, body composition were determined. Hemodynamic measurements were also taken into account. Results: Resting metabolism, waist circumference (WC) and hip circumference had low mean levels in both HIV positives groups compared to HIV negative group. On lipid profiles visceral fat (VF), whole fat (WF) had low mean levels but skeletal muscle fat (SMF) showed the highest mean levels in both HIV positive groups. All the blood pressures between HIV groups were on a normal range scale. Mean values of endothelin and nitric oxide are increased in HIV positive not on ART and HIV (+) on ART compared with the HIV negative group. Conclusion: NO, ET-1, ART and HIV itself were associated with the pathogenesis of endothelial dysfunction in persons with HIV infection. Elevated endothelial markers namely ET-1 and NO can lead to improvement of endothelium dependent relaxation to some extent but not completely. Although these markers have deleterious effect on the endothelium but can also serve as up-regulator of hypertension. Key words: HIV-infection, antiretroviral therapy, endothelial dysfunction, Endothelin1 (ET-1), nitric oxide (NO), blood pressures (BPs). , Thesis (MSc) -- Faculty of Health Sciences, 2015
- Full Text:
- Date Issued: 2015
- Authors: Zono, Sinethemba
- Date: 2015
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/11260/2909 , vital:43105
- Description: Background: Dysfunction of the vascular endothelium is an early finding in the progression of cardiovascular disease and is closely related to clinical events in patients with obesity and hypertension. Vascular function is mediated by nitric oxide (NO) and endothelin (ET-1) which serve as natural counterparts. The aim of the study was to determine the physiological effects of HIV infection, blood pressure and body composition on the changes of ET-1 and NO and association between ET-1 and NO. Methods and results: This was a descriptive and comparative study. A Quota sample method was used. The study population consisted of 154 participants categorized into the following groups: 57 HIV negative participants (A), 40 HIV positive not on treatment participants and 57 HIV positive on treatment participants. Enzyme immunoassay kit was used for the quantitative determination of ET-1 and Nitrate/nitrite colorimetric assay kit was used for the determination of NO. Anthropometric measurements, body composition were determined. Hemodynamic measurements were also taken into account. Results: Resting metabolism, waist circumference (WC) and hip circumference had low mean levels in both HIV positives groups compared to HIV negative group. On lipid profiles visceral fat (VF), whole fat (WF) had low mean levels but skeletal muscle fat (SMF) showed the highest mean levels in both HIV positive groups. All the blood pressures between HIV groups were on a normal range scale. Mean values of endothelin and nitric oxide are increased in HIV positive not on ART and HIV (+) on ART compared with the HIV negative group. Conclusion: NO, ET-1, ART and HIV itself were associated with the pathogenesis of endothelial dysfunction in persons with HIV infection. Elevated endothelial markers namely ET-1 and NO can lead to improvement of endothelium dependent relaxation to some extent but not completely. Although these markers have deleterious effect on the endothelium but can also serve as up-regulator of hypertension. Key words: HIV-infection, antiretroviral therapy, endothelial dysfunction, Endothelin1 (ET-1), nitric oxide (NO), blood pressures (BPs). , Thesis (MSc) -- Faculty of Health Sciences, 2015
- Full Text:
- Date Issued: 2015
Comparison between Endothelin, Nitric Oxide and their Association to Blood Pressure and Body Composition in HIV Patients, in Mthatha
- Authors: Zono, Sinethemba
- Date: 2011
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/11260/3550 , vital:43627
- Description: The motivation for this study is that Health Resource Centres of the Eastern Cape ought to provide access to high quality, relevant and appropriate information that is evidence-based and responsive to the needs of health professionals thereby assisting health professionals accomplish their tasks. In order to provide access to quality information, the Health Resource Centres are expected to provide information services within an acceptable framework of service standards. This study seeks to explore the implementation of standards in the Health Resource Centres of the Eastern Cape. The study was carried out in two phases namely a literature review and a survey. The study used the quantitative method of collecting data by means of a cross-sectional survey. A self administered questionnaire was used to collect data. The questionnaire was piloted in the Queenstown Health Resource Centre, after which appropriate changes were made before the commencement of data collection. The study was conducted in the three other Health Resource Centres of the Eastern Cape, namely Umtata Health Resource Centre, East London Health Resource Centre and Port Elizabeth Health Resource Centre. Health Resource Centre managers completed the questionnaires. The overall findings of this study show that the three Health Resource Centres uphold service standards. The results show that the Health Resource Centres were compliant with the service standards relating to both services and management areas. The Health Resource Centres were more compliant with standards relating to service areas than they were to standards relating to management areas. The results of the study furthermore demonstrate that the Umtata Health Resource Centre was most compliant regarding service areas (86,20%) compared to the East London Health Resource Centre (82,75%) and the Port Elizabeth Health Resource Centre (72,41%). In regard to management areas, the results show that the Umtata Health Resource Centre and East London Health Resource were more compliant than the Port Elizabeth Health Resource Centre. However certain aspects of their service such as availability of space, health and safety, staff performance and development, quality leadership and design and financial management need further attention. The study suggests that further research is required to objectively verify implementation of standards, to solicit health professionals’ opinions and experiences about the services provided by these Health Resource Centres and to find out if there is any connection between the quality of services provided and the quality of patient care. , Thesis (MSc) -- Faculty of Health Sciences, 2015
- Full Text:
- Date Issued: 2011
- Authors: Zono, Sinethemba
- Date: 2011
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/11260/3550 , vital:43627
- Description: The motivation for this study is that Health Resource Centres of the Eastern Cape ought to provide access to high quality, relevant and appropriate information that is evidence-based and responsive to the needs of health professionals thereby assisting health professionals accomplish their tasks. In order to provide access to quality information, the Health Resource Centres are expected to provide information services within an acceptable framework of service standards. This study seeks to explore the implementation of standards in the Health Resource Centres of the Eastern Cape. The study was carried out in two phases namely a literature review and a survey. The study used the quantitative method of collecting data by means of a cross-sectional survey. A self administered questionnaire was used to collect data. The questionnaire was piloted in the Queenstown Health Resource Centre, after which appropriate changes were made before the commencement of data collection. The study was conducted in the three other Health Resource Centres of the Eastern Cape, namely Umtata Health Resource Centre, East London Health Resource Centre and Port Elizabeth Health Resource Centre. Health Resource Centre managers completed the questionnaires. The overall findings of this study show that the three Health Resource Centres uphold service standards. The results show that the Health Resource Centres were compliant with the service standards relating to both services and management areas. The Health Resource Centres were more compliant with standards relating to service areas than they were to standards relating to management areas. The results of the study furthermore demonstrate that the Umtata Health Resource Centre was most compliant regarding service areas (86,20%) compared to the East London Health Resource Centre (82,75%) and the Port Elizabeth Health Resource Centre (72,41%). In regard to management areas, the results show that the Umtata Health Resource Centre and East London Health Resource were more compliant than the Port Elizabeth Health Resource Centre. However certain aspects of their service such as availability of space, health and safety, staff performance and development, quality leadership and design and financial management need further attention. The study suggests that further research is required to objectively verify implementation of standards, to solicit health professionals’ opinions and experiences about the services provided by these Health Resource Centres and to find out if there is any connection between the quality of services provided and the quality of patient care. , Thesis (MSc) -- Faculty of Health Sciences, 2015
- Full Text:
- Date Issued: 2011
- «
- ‹
- 1
- ›
- »