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Establishment of a high-content neurodegenerative disease model screening platform

  • Authors: Swanepoel, Bresler
  • Date: 2023-12
  • Subjects: Molecular neurobiology , Nervous system -- Diseases , Nervous system -- Degeneration
  • Language: English
  • Type: Doctorial theses , text
  • Identifier: http://hdl.handle.net/10948/62644 , vital:72906
  • Description: The identification of viable therapeutic targets and new treatments for central nervous system disorders, especially neurodegenerative diseases, remain major challenges in the field of drug discovery. Over the past few years there has been a steady decline in the turnaround time of current screening processes to yield viable drugs. Therefore, an increasing need exists for better technologies, protocols, and the screening of larger libraries. High-throughput screening provides the best solution to this problem and has become a key part in the drug discovery and development process. Likewise, high-content analysis has gained popularity over the past few years and is suitable for high-throughput screening. The aim of this study was to establish a comprehensive in vitro neuroprotective screening platform incorporating high throughput screening, using Parkinson’s disease as the neurodegenerative disease of interest. To evaluate the success of this platform, the neuroprotective potential of two mushrooms (Hericium erinaceus and Phlebopus sudanicus), two plants (Lippia javanica and Myrothamnus flabellifolia) and two seaweeds (Eucheuma denticulatum and Kappaphycus alvarezii) were investigated. Aqueous and ethanolic extracts of the selected natural products were evaluated across 21 parameters associated with four hallmarks of neurodegeneration: acquiring senescence, acquiring cell death, neuroinflammation and altered metabolism/cell survival. Based on the effects of these selected natural products on the 21 parameters, their potential mechanisms of action were elucidated. In addition to this, the natural products were scored under each of these therapeutic targets in an attempt to identify the most suitable animal models for future studies. The scoring system indicated that animal models investigating anti-senescence ability would be more suited for extracts of H. erinaceus, P. sudanicus and E. denticulatum whereas studies investigating the prevention of cell death would be more suited for extracts of E. denticulatum, L. javanica and K. alvarezii. Likewise, models based on neuroinflammation would be best suited for extracts of H. erinaceus, E. denticulatum and L. javanica while studies examining altered metabolism/cell survival would be best suited to extracts of H. erinaceus, E. denticulatum, K. alvarezii and M. flabellifolia. Considering the pleiotropic nature of the selected natural products, models that can combine these therapeutic targets could be of great interest. 6-OHDA proved to be capable of inducing favourable effects, in all the parameters investigated, with regard to a neurodegenerative state. However, it is known to have some disadvantages when it comes to pathological features such as the lack of the ability to induce Lewy body formation. Choosing the correct inducer remains a daunting task and no model, whether cell-based or animal-based, exists yet in which all the features of neurodegenerative diseases have been successfully replicated. The limitations of the current models, however, does not mean that they do not produce valuable insights. This is especially true if the mechanism of action for a specific compound or natural product is unknown. Animal models are still indispensable for the validation and interpretation of the results obtained from cell models with particular importance to toxicity. Therefore, this study assessed the best studied extract with the highest overall score for its toxicity using a zebrafish larvae-based model. Assessment of the toxicity of H. erinaceus revealed that both aqueous and ethanolic extracts resulted in death at the highest concentrations. This was supported by the results obtained in the in vitro cytotoxicity screening. In conclusion, this highlighted the importance of using physiologically relevant concentrations and supported the translational value of the current cell-based screening model to animal models and possibly humans. The findings of the present study suggest that a scoring system, which categorizes the different activities of selected natural products into distinct groups, can be a useful tool to improve the translatability of in vitro results to animal models. Furthermore, the current study arguably provides the most comprehensive neuroprotective screening platform in existence. Future research can look at expanding the platform through incorporation of additional parameters based on other hallmarks of neurodegeneration, not covered in this study, including protein folding and aggregation, altered epigenetics and the examination of other neuronal markers such as the involvement of astrocytes, oligodendrocytes, and microglia. In addition to this, future research can make use of more sophisticated cell models such as differentiated, human induced pluripotent stem cells and three-dimensional cultures. , Thesis (PhD) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2023
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  • Date Issued: 2023-12

Evaluating antidiabetic properties of selected African medicinal plants in a cell-based model

  • Authors: Sirkhotte, Saeedah , Reddy, Shanika
  • Date: 2023-12
  • Subjects: Medicinal plants -- South Africa , Insulin resistance , Gluconeogenesis
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/62600 , vital:72827
  • Description: The World Health Organisation lists diabetes as one of the major non-communicable diseases affecting the world, and its prevalence is expected to increase rapidly. Type II diabetes mellitus (T2DM) is characterised by insulin resistance and impaired blood glucose control. T2DM is of growing concern within South Africa, with 10.8% of the population currently diagnosed. The popularity, as well as availability, of traditional plant-based medicine in South Africa, might provide a solution. Antidiabetic potential is commonly tested by in vitro assays, however the methods to test this potential via gluconeogenesis are limited. This project aimed to optimise an in vitro hepatic gluconeogenesis model. In addition, this project aimed to determine the antidiabetic properties of Prunus africana, Hypoxis stellipilis, and Eriocephalus africanus by in vitro analysis. These properties were examined in human hepatoma cells (C3A cell line) and rat pancreatic cells (INS1 cell line) and methods included: cytotoxicity analysis, Amplex® red glucose oxidase assay, antibody staining, gene expression analysis by RT-qPCR, oxidative stress analysis, and calcium signaling for insulin release. Insulin resistance was successfully induced by exposing C3A hepatocarcinoma cells to a combination treatment of 50 μM dexamethasone, 1.25 mM fructose and 0.125 mM palmitic acid for a period of three days. Thereafter, gluconeogenesis was assessed using the Amplex® red glucose oxidase assay. The established model was effective in inducing insulin resistance and upregulating gluconeogenesis. Of the tested plant extracts, H. stellipilis showed the most potential as an antidiabetic treatment. It had low toxicity, significantly decreased hepatic glucose production and reduced the amount of phosphoenolpyruvate carboxykinase (PCK) and well as PCK gene expression, and reduced lipid content and reactive oxygen species (ROS) in the C3A cell line. H. stellipilis increased calcium signalling in INS1 rat insulinoma cells, however there was a decrease in expression of genes for insulin and glucose transporter 2 after 6 hr exposure. H. stellipilis appears be beneficial as an antidiabetic treatment. Although antidiabetic studies have been done on other Hypoxis species, this is the first study on the effects of H. stellipilis on gluconeogenesis and diabetes. , Thesis (MSc) -- Faculty of Science, School of Biomolecular & Chemical Sciences, 2023
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  • Date Issued: 2023-12

Evaluation of the antidiabetic potential, safety and efficacy of selected natural products using zebrafish larvae and in vitro bioassays

Evidence of Late Holocene extreme marine wave event (tsunami) deposits along the South African coast and implications for coastal zone management

  • Authors: Mfikili, Athi Nkosibonile
  • Date: 2023-12
  • Subjects: Tsunamis -- South Africa , Coasts -- Risk assessment , Sediments (Geology)
  • Language: English
  • Type: Doctoral theses , text
  • Identifier: http://hdl.handle.net/10948/62517 , vital:72811
  • Description: Although extreme marine wave events such as tsunamis and storm surges have always been part of human existence, their impact on ever-growing coastal population of the world’s coast was highlighted by the recent catastrophic events over the past three decades. Although in situ observations and eyewitness accounts have improved our ability to record and interpret wave inundation by modern extreme marine events, records documenting inundation by pre-historic and historical events are relatively sparse to provide reasonable information on their distribution, magnitude and frequency intervals in most parts of the world. Owing to consequences these natural coastal hazards have on coastal population and infrastructure of the world’s coast, onshore sedimentary deposits preserved in the geological records have been extensively utilized by scientists worldwide to reconstruct the record of pre-historic and historical events and establish the recurrence interval of future events. Although studies investigating inundation of past tsunami has increased worldwide over the past two decades, research on extreme marine inundation has received little attention along the South African coast, despite known inundation by recent events and potential source mechanisms. Therefore, the aim of this study is to investigate sedimentary evidence of past tsunamis and related extreme marine wave events (i.e., storm surges) preserved in the recent geological archive of several coastal environments along the South African coast. The Swartkops, Kabeljous, Kromme and Keurbooms estuaries located in log-spiral bays along the south-east coast and sheltered coastal systems of the Berg Estuary and Verlorenvlei as well as coastal lowlands of the Dwarskersbos on the west coast were selected as the study sites. The sediment cores were collected from these coastal environments and identification of extreme marine wave inundation was based on the recognition of distinct anomalous sand layers. To characterise sediment transport and reconstruct provenance source origin of the deposits, a combination of sedimentological (i.e., grain size distribution), exoscopy (i.e., quartz grain surface microtextures) and micropaleontological (i.e., foraminiferal assemblages) proxies were utilized. Furthermore, age estimation of the deposits was determined using a combination of radiocarbon (14C) and radiometric (137Cs and 210Pb) dating methods.Evidence of coastal flooding by high-energy marine wave events is found preserved in the stratigraphic records of Swartkops and Kabeljous estuaries along the south-east coast and lowlands of Dwarskersbos on the west coast in the form of anomalous sand deposits (layers). The anomalous deposits of Swartkops and Kabeljous estuaries generally consist of gravel-sized shell fragments often with a sharp erosive contact suggesting deposition by a highly energetic marine wave event. Although the preservation varies between cores, a maximum of three anomalous sand depositional layers are preserved in the Swartkops whereas only a single layer in the Kabeljous Estuary with a basal layer of calcrete deposits. 210Pb and 14C dating, constrain the ages of the younger deposits (i.e., the uppermost layer) at Swartkops between 1770-1804 AD and 339-3 cal. BP (1611-1947 cal. AD), respectively. Although these ages span over a wide period, they are interpreted to represent evidence of one of the historical tsunamis generated in the subduction zones of the Indian Ocean e.g., 1762 AD and 1797 AD events generated by 8.8 and 8.0 Mw earthquakes in the Arakan and Sunda Subduction Zones, respectively. Furthermore, the deposits could also represent geological evidence of the 1833 Mentawai events whereas evidence of 1883 Krakatau tsunami is not disregarded, since this event reportedly inundated Algoa Bay. On the other hand, the 14C dating constrain the ages of the second anomalous deposits between 1526-1253 cal. BP (424-697 cal. AD), whereas the older anomalous deposits preserved in the deeper sections of the Swartkops cores as well as the backwater channel of the Kabeljous Estuary are constrained to have been deposited around 4000 cal. BP. Although there is no known locally documented extreme marine wave event during this period, these deposits are interpreted to represent late and mid-Holocene tsunamis associated with mega-thrust subduction zones of the Indian Ocean whereas local submarine landslide generated event are also not disregarded entirely. On the west coast, three anomalous deposits representing extreme marine wave inundation are preserved in the coastal lowlands of the Dwarskersbos. Although the general sedimentary features and thickness vary between the deposits, the first anomalous deposits in the uppermost section of the cores consist of medium sand with scattered shell fragments whereas, the third anomalous deposits in the deeper section of the cores are generally coarser with gravel-sized shell fragments and sharp erosive basal contacts. By contrast, the second anomalous deposits consist of three successive sub-layers of yellow sand with variable sedimentary features and these layers represent successive wave inundation events. Although the sedimentary characteristics of these sub-layers varies, it was noted that the lowermost layers consist of coarser and less well sorted sediments often with basal erosive contact, suggesting that the first wave was more energetic than the two-succeeding waves. Furthermore, calibrated 14C dated shell fragments from the first and second anomalous deposits yielded ‘post-bomb’ ages suggesting deposition after 1950 AD. Given their position within the stratigraphic records, the two deposits are interpreted to represent first geological evidence of the 2008 west coast and 1969 Dwarskersbos events, respectively. On the other hand, the 14C dated shell fragments constrain the deposition of the third anomalous deposits between 315-0 cal. BP (1635-11950 cal. AD) and 358-0 cal. BP (1592-1950 cal. AD), respectively. The third anomalous deposits are interpreted to the 07 April 1620 event, which was described as ‘Two startling thunderclaps’ near Robben Island. Although initially associated to earthquakes, there are no records of an earthquake during this period, therefore, we postulate that the 1620 event could have been a similar event to that of 2008 that inundated the west coast region and/or an unknown event. While it is acknowledged that the absence of reliable source mechanisms poses a great challenge in the reconstruction of extreme marine wave events inundation along the south-east coast, the findings of exoscopy and micropaleontological analyses suggest that the deposits were transported to their depositional environments, although resultant microtextural features and occurrence of individual foraminiferal species and their taphonomical conditions is dependent on coastal setting. The south-east coast deposits consist of highly diverse foraminiferal assemblages, which are dominated by marine and marginal-marine taxa with relatively low abundances of estuarine-brackish species and variable taphonomical conditions. Furthermore, the mechanical-induced features such as percussion marks, fresh surfaces with sharp edges were still preserved on quartz grain surface of the Swartkops deposits, despite dominance by chemical-induced features such as dissolution. By contrast, grain surface microtextural signatures of the Dwarskersbos deposits are dominated by mechanical features such as fresh surfaces and v-percussion marks. Furthermore, the foraminiferal assemblages of the Dwarskersbos deposits consist of exclusively marine and marginal-marine species, suggesting that the sediments were sourced from shallow water environments as well as the adjacent beach. It was further noted that the foraminiferal tests of these deposits consist of higher abundance of corroded and fragmented tests indicating deposition by high-energy conditions. , Thesis (D.Phil) -- Faculty of Science, School of Environmental Sciences, 2023
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  • Date Issued: 2023-12

Experiences of mothers who are on tuberculosis treatment While caring for their children in Nelson Mandela Bay health district

  • Authors: Mwadiwa, Chiedza
  • Date: 2023-12
  • Subjects: Caring experiences -- Nelson Mandela Bay , Tuberculosis treatment
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/62935 , vital:73071
  • Description: Women and mothers have an important role to play as caregivers of their children. However, mothers are often faced with challenges with fulfilling this important role. Many women value the caring role as a mother over other areas of their lives, and for ill women, such as those with tuberculosis (TB) and those on TB treatment, it can be difficult to relinquish maternal responsibility. Indeed, many mothers in South Africa and other low- and middle-income countries develop TB during pregnancy and postpartum because their immune systems are compromised. For a mother who is chronically ill, carrying out a mother’s caregiving role presents a range of challenges. However, few studies have addressed this problem or explored the experiences of such mothers. The purpose of the study was to understand the experiences of mothers who are on TB treatment while caring for their children in order to establish their support needs and thereby develop recommendations to assist CHWs, nurses and nurse managers at primary healthcare (PHC) clinics to provide optimum care to such women. The Socio-Ecological model was used as the theoretical lens to explore the phenomenon under investigation. A qualitative, exploratory-descriptive research design was identified as most suited to respond to the research question. Purposive sampling was used to select both the participants and the clinics in the Nelson Mandela Bay Health District (NMBHD) for the purpose of this study. The population was mothers on TB treatment caring for their children (aged five years or younger) who were attending either one of the two of the largest PHC clinics in Sub-district C in the NMBH. Altogether ten mothers on TB treatment caring for their children took part in individual semi-structured interviews conducted telephonically. Ethical clearance was obtained from Nelson Mandela University and permission was obtained from the Department of Health (DoH), district office, operational managers at the respective clinics, and the participants involved in the study. Trustworthiness was enhanced by ensuring credibility, transferability, dependability, and confirmability. Ethical principles were upheld throughout the course of this study namely respect for persons, beneficence and justice. All interviews were recorded and transcribed, and the data was analysed using Tesch’s method of data analysis to identify the themes. Three themes came out of the data, namely: Theme 1: Mothers expressed having to navigate a range of physical and psychosocial challenges while caring for their v children; Theme 2: Mothers struggled to perform motherly roles while on TB treatment; Theme 3: Mothers described their relationships with their family, community members and clinic health practitioners. The experiences of the participants were described using direct quotations from the interviews followed by a literature control used to verify the participants’ experiences. Thereafter, the findings were used to develop recommendations to optimise the care and support of mothers on TB treatment who are caring for their children. Four recommendations were developed: Recommendation 1: Prepare and support mothers with TB to care for themselves and their children; Recommendation 2: Assist CHWs and nurses to care and support mothers with TB and their children; Recommendation 3: Prepare and support family members to support mothers with TB and their children and Recommendation 4: Educate community members regarding the needs of mothers with TB. There is limited existing research on mothers who are on TB treatment while caring for their children. This research study helped to fill this gap, particularly in an urban Eastern Cape context. The findings illustrated mothers’ physical and psychosocial challenges, as well their role-related challenges and finally the challenges related to the various spousal, family, community and clinic relationships that influence their experience of caring for their child while on TB treatment. , Thesis (MA) -- Faculty of Health Science, 2023
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  • Date Issued: 2023-12

Experiences of psychological practitioners when working with Isixhosa speaking minors in the Eastern Cape.

  • Authors: Matushe, Masakhane
  • Date: 2023-12
  • Subjects: language barriers -- Eastern Cape , Psychological practitioner
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/62884 , vital:73062
  • Description: Language barriers continue to pose challenges in education and the health sector where psychological assessments and tests are administered in a language that is different from that of the client. The implication this has on the interpretations of test-taker scores may be bias against those whose first language is not English or Afrikaans, which are two of the primary languages majority of the tests currently used in the South Africa are normed against. This study aimed to explore the implications of the current language repertoires on test-taker performance. This was achieved through exploring the experiences of psychological practitioners who use English language psychological tests on isiXhosa speaking child clients in the Eastern Cape. The methodology followed an exploratory-descriptive, qualitative design, adopting Lincoln and Guba's model of trustworthiness. The researcher employed a qualitative method with an exploratory-descriptive research design, and participants were recruited by utilizing a purposive sampling strategy. Thematic analysis was used as a means of data analysis,and the following themes emerged and were discussed: The use of translators & interpreters, and the challenges thereof; practitioner’s own language proficiencies and limitations; cultutral influence and langaage exposure of clients; Adaptation as well as revision of decolonization of testing measures; and training psychological practitioners. , Thesis (Ma) -- Faculty of Health Science, 2023
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  • Date Issued: 2023-12

Exploring culturally adapted psychological interventions for mental illness in South Africa: A scoping review

  • Authors: Mbatha, Andiswa
  • Date: 2023-12
  • Subjects: Cultural Adaptation , Evidence-Based Treatments
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/62898 , vital:73065
  • Description: Culturally appropriate interventions are crucial for its universal applicability. Although it is well documented that mental health practitioners need to consider cultural factors when working with clients, there is a paucity of research concerning culturally adapted psychological treatments within South Africa. Mental Health practitioners use borrowed Westernised methods of psychological interventions, whose effectiveness has been proven to work on people with different values and belief systems from those of South Africa. This study sought to map the literature on culturally adapted psychological interventions in the South African context. The main research question of the study is: “According to the literature, what are the culturally adapted psychological interventions available for use in the South African context?” Employing the scoping review methodology, published literature was sourced from various electronic databases. The data is presented in a table format using the thematic framework. The study found that out of 250 records that were retrieved, we identified nine articles describing four distinct interventions in treating three mental illnesses in South Africa. Cognitive behaviour therapy (n = 3), behaviour activation (n=2) mindfulness-based stress reduction (n=2) interpersonal therapy (n=1) and Motivational interviewing (n=1) surfaced as culturally adapted psychological interventions to treat people with depression, trauma and substance use disorder. Improvement in symptoms was a common result of all therapies. The potential benefit of the study is to provide recommendations that will inform further research and clinical practice. , Thesis (Ma) -- Faculty of Health Science, 2023
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  • Date Issued: 2023-12

Exploring the leadership agility in industry 4.0 for company x in Gqeberha

  • Authors: Cairncross, Merle Vera
  • Date: 2023-12
  • Subjects: Leadership -- South Africa , Industry 4.0 , Business intelligence
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/65577 , vital:74193
  • Description: In today’s dynamic business landscape, more organisations are progressively attempting to become agile by implementing agile corporate structures, processes and leadership frameworks. By effectively incorporating leadership agility into their processes, leadership can be better prepared to improve its decision-making agility, further able to deploy strategies for improved detection and response to failure as well as improve communication in the organisation. This treatise explores the critical role of leadership agility in enabling organisations to navigate the challenges of a rapidly evolving environment such as Industry 4.0 and capitalise on emerging opportunities. For this study, qualitative data was collected from functional level management by means of semi-structured, face-to-face interviews. The interviews aimed to identify behaviours and beliefs that contribute to an agile organisation, examine barriers impeding agile decision-making and explore strategies to cultivate an agile decision-making culture. By understanding the key factors that enable leadership agility and promote agility within decision-making processes, this research aimed to provide valuable insights for organisations seeking to thrive in the dynamic landscape of Industry 4.0. Through literature analysis and interviews, the researcher concluded that agile leaders possess crucial competencies and behaviours that allow them to effectively navigate the challenges and opportunities of Industry 4.0. These include effective communication, openness to change, innovative thinking, flexibility, self-management, developing others and organisational awareness. Agile leaders strategize and prepare their organisations in Industry 4.0 by adopting an adaptive leadership style, cultivating an agile decision-making culture, encouraging continuous improvement, promoting creativity and innovation and responding swiftly to changes, thus gaining a competitive edge in Industry 4.0. Embracing leadership agility enables organisations to capitalise on Industry 4.0’s opportunities and navigate its challenges, ultimately fostering a competitive business environment. By organising and synthesising the knowledge obtained in this study, a framework is proposed for agile leadership, which consolidates , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business School , 2023
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  • Date Issued: 2023-12

Exploring the psychological and emotional understanding of Amagqirha within the Eastern Cape province, South Africa

  • Authors: Ncapayi, Abongile
  • Date: 2023-12
  • Subjects: traditional healers , Indigenous Knowledge , Cultural religion
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/62947 , vital:73074
  • Description: Indigenous knowledge systems influence mental health understanding and treatments. Amongst the Xhosa’s (amaXhosa), a person may receive a ‘calling’ from the ancestors, usually associated with symptoms that would be characterized as a mental illness. However, the symptoms experienced during the calling, usually dissipate once training has been received. One of the categories within traditional healers are amagqirha, also known as diviners. These are individuals who receive the ‘calling’. Thereafter, they undergo extensive training and become blessed with clairvoyant “powers” to divine and act as mediators between the living and the dead. This study aimed to explore the psychological and emotional understanding of amagqirha of the Xhosa culture, within the Eastern Cape, South Africa. In doing so, the study centralizes the experiences of individuals within cultural spaces, allowing for commentary on the psychological and emotional understanding of the amagqirha. Furthermore, this study focused on the work that amagqirha do in communities and how this ultimately affects them. This study sought to understand the experiences and perceptions of the individuals who are affected by this ‘calling’. The researcher employed a qualitative method with an exploratory-descriptive research design. Ten participants were recruited by utilizing a purposive snowball sampling strategy. Data was collected using a semi-structured interview due to the sensitivity of the demographic of the study. Ethics were adhered to. Additionally, trustworthiness was guided by Lincoln and Guba’s (1985) four constructs: credibility, dependability, transferability, and confirmability. Thematic analysis was used as a means of data analysis, as presented by Braun and Clarke (2006). The themes identified were: The collateral damage/profuse repercussions cast upon by the ancestors due to inaction (either by them or those that case before them), the severity of the emotional and psychological effects is equally prevalent prior and during their journey of vi ubugqirha, methods that may assist in alleviating the emotional and psychological symptoms, understanding of mental health, awareness of their own mental health status, and help-seeking (psychological services). The main findings suggested that there is a general understanding of the term ‘mental health’ amongst amagqirha. Additionally, the findings revealed that amagqirha experienced emotional and psychological symptoms/effects, prior to and during the journey of ubugqirha - these were due to the lack of understanding and fear. Furthermore, the findings suggesting that amagqirha embarked on various help-seeking measures, i.e., seeking psychological services or leaning into seeking guidance from their ancestors. However, they were met with barriers as well, i.e., finding a mental health practitioner with awareness on African spirituality, and dealing with the stigma that comes with help-seeking. , Thesis (Ma) -- Faculty of Health Science, 2023
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  • Date Issued: 2023-12

Exploring the role of livelihood diversification of household food security in Umzimvubu Local Municipality

  • Authors: Tikilili, Noluthando
  • Date: 2023-12
  • Subjects: Food security -- South Africa -- Eastern Cape , Sustainable agriculture -- South Africa -- Eastern Cape , Food industry and trade -- South Africa -- Eastern Cape
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/66054 , vital:74324
  • Description: The study sought to explore the role of livelihood diversification for household food security in rural communities of Umzimvubu Local Municipality for sustainable development. The study adopted an interpretive paradigm as it gave the researcher appropriate information from a group of participants who better understand the livelihood assets. The qualitative research approach was adopted for the study due to its ability to appreciate the opinions, feelings and experiences of distinct individuals in order to give meaning to their behaviours. To gain better inferences and insights into this phenomenon, the researcher used semi-structured interviews with smallholder farmers who depend on practising farm activities for their livelihoods. The findings of the study revealed that due to retrenchment and the increase in unemployment rate, families are experiencing income inadequacy that has urged rural households to engage mostly in on-farm activities as a way of generating income and supplementing their livelihoods to sustain their families. Additionally, the findings unveiled that the efforts by government as well as non-government stakeholders to mitigate the effects of poverty by introducing the local entrepreneurs to the formal market, were evident. However, there are no consistent and stable programmes and policies to extend the market, or to encourage commercial farmers and smallholder farmers to work together to improve rural economies and transfer the much-needed skills to subsistence farmers. The study recommends that the government should play a leading role in capacitating rural communities and adequate funding should be made available to execute off-farm and non-farm activities to tackle the issues of food security and eliminating poverty. Also, with the emergence of a changing climate, there is a need for the Eastern Cape government to erect irrigation schemes, which can be done to sustain on-farm production and productivity for the rural communities. There is a need for the government to facilitate the introduction of stable and consistent programmes and efficient and effective policies which will enforce the commercial and small-holder farmers to work together and ensure that the much-needed skills and expertise are transferred to the marginalised group whilst improving the rural economy and meeting the market demands. , Thesis (MA) -- Faculty of Business and Economic Sciences, School of Economics, Development and Tourism, 2023
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  • Date Issued: 2023-12

Exploring university level admissions decision-making based on access testing and undergraduate admissions variables

  • Authors: Oakes, Elizabeth
  • Date: 2023-12
  • Subjects: decision-making , Social-Judgement Theory , Cognitive-Continuum TheoryLens Model Equation
  • Language: English
  • Type: Doctoral's theses , text
  • Identifier: http://hdl.handle.net/10948/62969 , vital:73078
  • Description: Decision-making is an essential everyday cognitive function. How people go about making judgements and decisions is difficult to pin down. The reason for this lies in the inherent nature of decision-making, which is uncertain and variable because decision-making is a human cognitive process that is context-dependent. However, the body of research on judgement and decision-making (JDM) is concerned with describing what people are 'actually' thinking, when they make decisions or judgements. This study applied the descriptive theories of the Social-Judgement Theory (SJT) and the Cognitive-Continuum Theory (CCT), in order to understand decision-making in an undergraduate, entry-level admission decision-making context, in which decision-makers used access testing and school results, to make admission decisions at Nelson Mandela University. The sample consisted of four consultants from the Centre for Access Assessment and Research (CAAR) who volunteered to participate in the study. While the sample was small, it was nonetheless deemed to be adequate as 57% of the consultants at CAAR were included in the sample. Using the SJT methodological approach, an experiment was conducted to mirror the real-life context of decision-making at CAAR. As CAAR consultants were used to test, and school results being presented on a profile when they made decisions, a sample of 120 of these was drawn from a repository, with 60 of them requiring decisions for degree admission (to B Com Accounting) and 60 for diploma admission (to the Diploma in Accountancy). Ten degree and 10 diploma profiles were duplicated to check for consistency in decision-making. As SJT suggests restricting the number of cues used, a process was instituted to identify the cues perceived to be used most frequently to make decisions at CAAR. This resulted in 5 cues being included on the cue profile. In Phase 1 of the experiment the CAAR consultants made admission decisions using a familiar cue profile in terms of how the information was presented visually and numerically. In phase 2 the information was presented using a different visual format, which was more closely aligned to the intuitive decision-making mode that most consultants used. A 2 x 2 within-subjects experimental design was thus employed with two independent variables, namely, profile type and program type. Descriptive statistics and correlational and regression analyses were used to describe the judgement policies of the consultants in terms of the time taken, the difficulty ratings, and the cue use and its importance). The indices of the Lens Model Equation (LME) of SJT were used to describe the decision-achievement levels, and the Task-Continuum Index (TCI) was computed to describe which cognitive modes were used. xvii The results revealed that decision-makers have unique, varied, and changeable judgement policies, with regard to the time taken, the perception of difficulty, and the decision outcomes and had a tendency to rely more on the school results, while the regression models derived indicated that test results made a stronger contribution to the decision outcome. The consultants found degree decisions easier than diploma decisions, and the consultants perceived the contribution and weighting of the cues somewhat differently, once the format of the cue profile had changed in Phase 2, although they made decisions more quickly in Phase 2. The decision-makers also displayed individualised patterns of decision achievement that differed for degree and diploma programs. Furthermore, in terms of the cognitive mode, decision-makers were thinking quasi-rationally and they largely used the cognitive modes of computer modelling or expert judgement. Thus, by synergistically using the two theories of JDM, the researcher was able to determine baseline information for understanding decision- making in an admission context. Furthermore, suggestions were made in terms of the nature of the feedback and training that could be provided to decision-makers to enhance their future decision-making. Suggestions were also made regarding how the methodology used and findings of this study could be applied in other contexts, such as when training students in psychological assessment. , Thesis (Ma) -- Faculty of Health Science, 2023
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  • Date Issued: 2023-12

Factors contributing to operational excellence in a pharmaceutical manufacturer in East London, South Africa

  • Authors: Monakali, Xolani
  • Date: 2023-12
  • Subjects: Organizational effectiveness , Performance , Production management , Industrial management Pharmaceutical industry -- South Africa -- East London
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/65795 , vital:74268
  • Description: To ensure that high quality, secure and effective pharmaceutical goods are consistently produced and supplied to the appropriate end user, pharmaceutical manufacturing companies operate in a highly regulated environment. The idea that quality is not assessed is incorrect; rather, it is built, is at the heart of this production environment. Since fulfilling deadlines on time in full is the benchmark for good customer service, to achieve this results in numerous quality limits that have an impact on the quick delivery of medicines. Companies are often competing for the same clients; thus, there is increasing competition, which is mostly due to the availability of reasonable and inexpensive generics. The most profitable company will be the one which operates and produces at low cost, with great efficiency and economies of scale. Furthermore, the generic pharmaceutical firm is not immune from the fundamental purpose of business, which is to make money for the shareholders and add value for the clients. In order to maintain competitiveness in a pharmaceutical company which operates in East London, South Africa, this study aims to identify the factors that lead to perceived operational excellence. Respondents were given a standardised questionnaire; thus the study employed a quantitative research methodology. The sample size for the study was determined by randomly selecting 100 employees, composed of Operators, General Assistants, Production Team Leaders, Production Pharmacists, Pharmacist Assistants and Artisans from Pharmaceutical Company X. With the aid of a research assistant, the questionnaire was distributed to and answered by respondents. The gathered data were analysed using the Statistical Package for Social Sciences (SPSS) version 27 for Windows. The results of the study were then shown in cross tabulations, pie charts and bar graphs. The main outcomes of the study revealed that the majority of consumers believed pharmaceutical products were of a high calibre in terms of quality. Furthermore, the majority of participants agreed that operational excellence is important in companies that produce fast-moving consumer goods, like the pharmaceutical industry does. The survey also revealed the need for operational excellence in the pharmaceutical industry. Given that quality in the pharmaceutical industry has grown to be a crucial issue, the study suggests that the importance of pharmaceutical product quality needs to be more widely understood. Academics, pharmaceutical companies and legislators will all benefit from the study. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business School, 2023
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  • Date Issued: 2023-12

Factors contributing to the productivity of operations at the port of Ngqura, Gqeberha

  • Authors: Mlonzi, Aluta Phathuxolo
  • Date: 2023-12
  • Subjects: Port Ngqura (Port Elizabeth, South Africa) , Harbors -- South Africa -- Port Elizabeth , Industrial productivity , Operations research
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/65773 , vital:74236
  • Description: Ports are the gateway to economic trade and a huge contributor to South Africa’s economy. Productivity has become a critical component for ports in the port industry as a means of enhancing market potential and competitiveness (Kuo, Lu, and Le, 2020). Therefore ports must investigate their productivity factors to stay competitive. This study sought to determine the factors that contribute to productivity at the Port of Ngqura. A qualitative research approach was employed in the study where data was obtained by conducting interviews with a sample of ten employees from Transnet Port Terminals and Transnet National Port Authority. Out of the ten employees identified, only four participants took part in the study. According to the respondents, the key factors contributing to productivity at the Port of Ngqura include the staff, efficient staff training, equipment, technology, and infrastructure. Furthermore, the respondents highlighted the importance of technology, specifically the planning and operations systems such as NAVIS and SPARCS, in optimising productivity. Infrastructure was also emphasised as a significant factor affecting productivity. Only the views of employees working at the Transnet Port Terminals and Transnet Port Authority at the Port of Ngqura were considered. The study achieved a low response rate. Based on the empirical research, the study could conclude by making the following recommendations that the Port of Ngqura should prioritise enhancing its operations by making significant investments in equipment and infrastructure. Through the adoption of an efficient human resource strategy, the port should also handle workforce problems brought on by resignations, voluntary separation plans (VSPs), and contract terminations. Planning for succession effectively is crucial to maintaining institutional knowledge. , Thesis (MPhil) -- Faculty of Business and Economic Sciences, School of Economics, Development and Tourism, 2023
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  • Date Issued: 2023-12

Factors influencing employee engagement in a flexible work environment: a study of the Road Accident Fund

  • Authors: Goqo, Nondumiso Zama
  • Date: 2023-12
  • Subjects: Road Accident Fund (South Africa) , Employee motivation , Flexible work arrangements , Work-life balance Personnel management
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/65600 , vital:74200
  • Description: Employee engagement is a critical aspect of organisational success, and with the increasing adoption of flexible working arrangements (FWAs), understanding its determinants becomes crucial. However, many organisations are struggling to keep employees engaged while offering them flexible working patterns. Therefore, this study aimed to determine the factors that influence employee engagement among employees of the Road Accident Fund (RAF) in South Africa after the introduction of flexible working arrangements. To achieve the main aim of this study, a literature study was undertaken on employee engagement and a flexible working environment. The main focus of the literature study was to determine the factors with the most potential to influence employee engagement in the context of a flexible working environment. These factors emerged as work-life balance, employee wellbeing, leadership, rewards and recognition, learning and development, employee involvement, effective communication and workplace flexibility. This led to conducting an empirical study utilising a self-administered online survey as the data collection instrument to determine the influence of these factors on the engagement of RAF employees. A scale was developed to determine these factors and the current engagement level of employees at the RAF was measured using the Utrecht Work Engagement Scale (UWES) (2002). A descriptive and correlational research design was employed, utilising a convenience sampling method with a final sample of 413 achieved. Data was analysed using descriptive and inferential techniques, including Cronbach’s Alpha, frequency distributions, measure of central tendencies and exploratory factor analysis (EFA), product moment correlation, t-tests, analysis of variance (ANOVA) and chi-square tests. This included the testing for potential relationships between the variables of interest.The results of the empirical study revealed some of factors that were identified in the literature review of this study were found to have a positive influence on the engagement of employees working in the flexible working environment offered by the RAF. These factors are employee well-being, leadership, reward and recognition, learning and development, employee involvement, effective communication and workplace flexibility (time). The factors that were excluded by the results were work-life balance and workplace flexibility (place). These exceptions imply that these factors have less influence on the overall employee engagement levels at the RAF. Moreover, the levels of engagement of RAF employees were found to be at a moderate level. Furthermore, the results indicated that regardless of whether employees utilised FWAs or not, their levels of engagement remained at a moderate level. In other words, the utilisation of FWAs did not appear to significantly impact on the overall engagement levels of employees, and both groups exhibited similar moderate engagement levels. The findings also suggest that the RAF should maintain and enhance the factors that have a positive influence on employee engagement. In addition, the organisation should work on addressing those factors that do not play as significant a role in influencing engagement as the other factors. By taking these steps, the RAF can effectively enhance the overall level of employee engagement among its workforce. , Thesis (MCom) -- Faculty of Business and Economic Sciences, School of Industrial Psychology and Human Resources, 2023
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  • Date Issued: 2023-12

Field mapping and geochemistry of lower Jurassic sediments and volcanics of the upper Karoo supergroup near Ha Mosi, Lesotho mountains

  • Authors: Valashiya, Khaya
  • Date: 2023-12
  • Subjects: Sediments (Geology) -- South Africa -- karoo basin , Geochemistry , Geological mapping
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/62687 , vital:72925
  • Description: Geological mapping in the Lesotho-Drakensberg Mountains spans over 100 years with du Toit and Stockley being the major contributors to the published maps and to the understanding of emplacement of the Karoo Large Igneous Province (KLIP) in the countries of South Africa and Lesotho. Despite the detailed previous work, there remains limited data on paleoenvironmental changes at the contact between the sedimentary and volcanic sequences of the upper Karoo Supergroup. This study aims to map the lithostratigraphic boundaries, volcano-sedimentary facies and faults near Ha Mosi in southern Lesotho. A total 48 rock samples were collected for petrography, XRF and ICP-MS analyses. The new results were used to characterize the local chemostratigraphy and to propose new regional correlations across Lesotho and South Africa. In this thesis, eight lithostratigraphic units were defined with a total thickness of 550 m. The first two units (Units 1 and 2) comprise massive and bedded sandstones, interpreted as possible floodplain and ephemeral lacustrine deposits; these are ascribed to the upper Stormberg Group. These units are unconformably overlain by locally preserved thin basaltic (Unit 3) flows that are characterised by high Zr/Nb and Zr/Y ratios; and low Ti/Zr and P/Zr ratios similar to the Golden Gate Unit of the Drakensberg Group. The lava flows are overlain by bedded sandstone ascribed to Unit 4 and volcaniclastic breccia ascribed to Units 5 and 6. Unit 6 consists of a monolithic breccia that is composed of angular sandstone clasts similar to those of the underlying Stormberg Group. The monolithic breccia transitions upwards into a massive megaclastic clast-supported volcanic breccia, which consists of angular to sub-rounded basaltic and doleritic boulders. Petrified wood fragments are found within the megaclastic breccia, indicating the presence of vegetation during deposition and enhanced preservation. Unit 6 laterally grades into Unit 5, which is characterised by poorly bedded breccia composed of angular sandstone, mudstone clasts with minor basaltic and doleritic clasts and, breccia intraclasts. The breccia units are often associated with reworked sediments interpreted to be deposited by fluvial systems. The breccia is conformably overlain by basaltic lava flows (Unit 8) characterised by high Ti/Zr and P/Zr ratios and moderate to low Zr/Y and Zr/Nb ratios compared to the Unit 3 lavas and is similar to that of the Sani Pass Unit of the Drakensberg Group. The basaltic sequences in the Ha Mosi studied area preserve both pahoehoe textures and pillow lavas, indicating subaerial and subaqueous volcanism. The studied lithologies are intruded by gabbro and dolerites of the Karoo Dolerite Suite at 183 Ma. This stratigraphy records the transition from sedimentation in the Karoo Basin through to a dominantly volcanic succession, which has importance in terms of the Toarcian extinction at ca. 182 Ma. Mapped faults and associated fractures are orientated predominantly NW-SE with the hanging walls moved maximum 80 m to the south. The different dykes and fault structures possibly relate to the Weddel Triple Junction that developed during the Early Jurassic break up of Gondwana, between 200 and 180 Ma. The mapped lavas show that the magma source was a chemically heterogenous mantle that was subjected to different degrees of partial melting, with the introduction of small-scale chemical heterogeneities. The geodynamic setting is comparable to the Afar Triangle of north-east Africa where active tectonics created a large-scale NW-SE orientated fault system in response to crustal thinning and rifting. In both the Afar and Lesotho, vertical movements created lowlands that allow for the preservation of volcanic breccia and basalts with pillow lavas. These findings show that existing geological models in the Drakensberg-Lesotho Mountains can be improved upon detailed field mapping and geochemistry. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2023
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  • Date Issued: 2023-12

Financial deepening and economic performance in South African commercial banks

  • Authors: Mpongoshe, Nomthandazo
  • Date: 2023-12
  • Subjects: Economic development , Banks and banking -- South Africa , Performance -- Measurement , Liquidity (Economics)
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/65829 , vital:74271
  • Description: Financial deepening and economic growth have received much attention in the literature. However, there remains a significant gap in understanding the relationship between financial deepening, and bank performance especially within the context of South African commercial banks. This research aims to investigate the empirical relationship between financial deepening and the performance of all South African commercial banks from 1987 to 2019. The research adopts a descriptive research design and utilizes secondary data along with time series analysis techniques. The research empirically investigates the relationship between financial deepening and bank performance, using financial deepening indicators such as Market Capitalisation (MC), Credit to the private sector (CR), Money Stock (MS), and Bank liquidity (BL). Control variables such as Gross Domestic Product (GDP), Inflation rate (IF), and Lending interest rate (LR) are also considered. The autoregressive distributed lag bounds testing (ARDL) method is employed to test the relationship between financial deepening and bank performance. The autoregressive distributed lag bounds testing (ARDL) method is employed to test the relationship between financial deepening and bank performance of South African commercial banks. The findings indicate that financial deepening has both short-term and long-term impacts on bank performance. Each component of the financial deepening indicators demonstrates a strong and statistically significant relationship with bank performance. This empirical evidence suggests that financial deepening has made a positive contribution to the profitability of South African commercial banks. Furthermore, the analysis reveals a long-run equilibrium relationship between financial deepening and the economic performance of the South African banking sector. This research addresses the gap between theoretical beliefs and empirical evidence by establishing a robust and positive contribution of financial deepening to the profitability of South African commercial banks. The findings highlight the significance of financial deepening in enhancing bank performance in South Africa. , Thesis (MCom) -- Faculty of Business and Economic Sciences, School of Economics, Development and Tourism, 2023
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  • Date Issued: 2023-12

Finite difference methods for Burgers-Huxley equation and biofilm formation

  • Authors: Tijani, Yusuf Olatunji
  • Date: 2023-12
  • Subjects: Burgers equation , Terrestrial heat flow , Applied mathematics
  • Language: English
  • Type: Doctorial theses , text
  • Identifier: http://hdl.handle.net/10948/62732 , vital:72934
  • Description: In this thesis, we constructed some versions of finite difference scheme for the Burgers-Huxley equation and for a set of partial differential equations (PDEs) arising in biofilm formation. The Burgers-Huxley equation serves as a fundamental model that describes the interaction between reaction mechanisms, convection effects, and diffusion transport. It has applications in the study of wave mechanics, population dynamics, physiology, fluid mechanics to list but a few. The study of biofilm formation is becoming increasingly important due to micro-organisms (i.e. bacteria) forming a protected mode from the host defense mechanism which may result in alteration in the host gene transcription and growth rate. Applications can be found useful in the treatment of bacterial infections, contamination of foods and water quality. We designed two nonstandard finite difference and two exponential finite difference schemes for the Burgers-Huxley equation. Numerical experiments with six cases and in three different regimes were studied. We show that the nonstandard scheme preserves the properties of the continuous equation which include positivity and boundedness. The stability region of the explicit exponential scheme was obtained and we outlined the algorithm for the implicit exponential scheme. The performance of the four schemes are compared in regard to absolute error, relative error, L1 and L∞ norms. For a singularly perturbed Burgers-Huxley equation, a novel nonstandard finite difference technique is constructed. It is demonstrated numerically that the NSFD scheme outperforms the classical scheme by comparing maximum pointwise errors and rate of convergence. We then solved the 2D Burgers-Huxley equation using four novel nonstandard finite difference schemes (NSFD1, NSFD2, NSFD3 and NSFD4). The numerical profiles from NSFD1 and NSFD2 exhibit some deviation from the exact profile. Our quest for a better performing scheme led to the modification of NSFD1 using the remainder effect technique. NSFD4 was designed by employing the time splitting approach. All the schemes preserve the properties of the continuous model (positivity and boundedness). The performance of all the schemes are analysed. We construct three nonstandard finite difference schemes for the equations modelling biomass equation and coupled substrate-biomass system of equations respectively. We checked the accuracy of our scheme by the conservation of physical properties (positivity, boundedness, biofilm formation and annihilation) since an analytical solution is not available. We show the instability, lack of conservation of physical properties by the classical scheme. Our proposed scheme shows good performance when compared with other results in the literature. The results here give more insight into the benefits of the nonstandard finite difference approximations. , Thesis (DPhil) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics , 2023
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  • Date Issued: 2023-12

Formulating an operational efficient strategy for the national health laboratory services in the Eastern Cape

  • Authors: Sizila, Wandile
  • Date: 2023-12
  • Subjects: National Health Laboratory Service (South Africa) , Public health laboratories -- South Africa -- Eastern Cape , Lean manufacturing
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/65990 , vital:74295
  • Description: This treatise presents the formulation of an operational efficient strategy for the National Health Laboratory Services (NHLS) in the Eastern Cape. Operational inefficiency in the NHLS has the potential to delay laboratory results delivery for necessary health intervention, which may have a negative impact on individuals’ health or lead to death. The aim of the study is to highlight inadequacies that may cause poor service delivery and formulate an operational plan for the NHLS in the Eastern Cape. Strategic efficiency is derived from the resource-based and agent theories. Even though there is a difference between service and manufacturing industries, the operational strategic framework can be used in both. A strategic framework is implemented by assessing market requirements and using the top-down or bottom-up approach. To monitor and regulate these strategies, one can utilise, among others, scorecards, corporate social responsibility and risk management. This is a qualitative research study using semi-structured interviews to gather information from 11 participants. The study targeted managers in the NHLS Eastern Cape region, with a non-probability method, as the large number of managers in the entire region made it impossible to do a random study. Furthermore, the data were analysed by the thematic analysis method. The literature review identified six factors that influence public sector efficiency, namely, compliance issues, ethics, financial expense management, resource optimisation, accountability and service delivery. The primary study revealed several inadequacies in the NHLS Eastern Cape, namely, inefficient human resources practices, underutilising technology, ambiguous policies, delayed turnaround time, lack of financial training for management and lack of support from cross-functional departments. In addition, the results of the study warrant the following recommendations: Proper orientation of staff, with modules pertaining not only to their duties and reporting structure but also to the policies of the organisations and conduct; SWOT analyses and surveys could also be used to assess internal staff and external factors that may hinder efficiency; the installation of solar panels for laboratories, starting with the vulnerable labs in remote , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business School, 2023
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  • Date Issued: 2023-12

Formulating an operational efficient strategy for the national health laboratory services in the Eastern Cape

  • Authors: Sizila, Wandile
  • Date: 2023-12
  • Subjects: Strategic planning , Organizational effectiveness , Success in business
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/65993 , vital:74294
  • Description: This treatise presents the formulation of an operational efficient strategy for the National Health Laboratory Services (NHLS) in the Eastern Cape. Operational inefficiency in the NHLS has the potential to delay laboratory results delivery for necessary health intervention, which may have a negative impact on individuals’ health or lead to death. The aim of the study is to highlight inadequacies that may cause poor service delivery and formulate an operational plan for the NHLS in the Eastern Cape. Strategic efficiency is derived from the resource-based and agent theories. Even though there is a difference between service and manufacturing industries, the operational strategic framework can be used in both. A strategic framework is implemented by assessing market requirements and using the top-down or bottom-up approach. To monitor and regulate these strategies, one can utilise, among others, scorecards, corporate social responsibility and risk management. This is a qualitative research study using semi-structured interviews to gather information from 11 participants. The study targeted managers in the NHLS Eastern Cape region, with a non-probability method, as the large number of managers in the entire region made it impossible to do a random study. Furthermore, the data were analysed by the thematic analysis method. The literature review identified six factors that influence public sector efficiency, namely, compliance issues, ethics, financial expense management, resource optimisation, accountability and service delivery. The primary study revealed several inadequacies in the NHLS Eastern Cape, namely, inefficient human resources practices, underutilising technology, ambiguous policies, delayed turnaround time, lack of financial training for management and lack of support from cross-functional departments. In addition, the results of the study warrant the following recommendations: Proper orientation of staff, with modules pertaining not only to their duties and reporting structure but also to the policies of the organisations and conduct; SWOT analyses and surveys could also be used to assess internal staff and external factors that may hinder efficiency; the installation of solar panels for laboratories, starting with the vulnerable labs in remote areas, wireless internet technology, mobile applications and software. The region also needs to practice good corporate governance, update its policies regularly and budget for all operations, including quasi fiscal activities. Lastly, support departments need to comply with an ISO certification. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business School, 2023 , Abstract.
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  • Date Issued: 2022-04
  • Date Issued: 2023-12

Functional traits and potential physical drivers of offshore benthic epifauna on the west and south coast of South Africa

  • Authors: Van Stavel, Jordan , Morris, Tamaryn
  • Date: 2023-12
  • Subjects: Marine ecology , Marine biology -- South Africa , Oceanography -- South Africa
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10948/62698 , vital:72931
  • Description: Offshore benthic ecosystems (> 200 m depth) are challenging to access and remain poorly studied globally. Epifaunal invertebrates comprise a critical trophic level in benthic ecosystems and can serve as indicators of the overall health and functioning. There is limited knowledge of South Africa’s offshore marine environment and benthic ecosystem functioning due to limitations in funding, resources, and the lack of suitable science-based monitoring tools which are vital for sustainable management into the future. The aim of this research was to improve the understanding of epifaunal functioning as well as their potential physical drivers in 13 South African offshore biogeographic ecotypes. The objectives of this study were threefold: 1) to investigate the functional composition of benthic epifauna from 13 biogeographic ecotypes, 2) to quantify the Functional Diversity (FD) associated with epifaunal traits between the different assemblages (i.e. biogeographic ecotypes), and 3) to evaluate the relationship between physical variables and epifaunal functional traits at the biogeographic ecotype level. Biological trait-based approaches were applied to a subset of 80 benthic epifaunal species collected from 909 offshore stations along the west and south coasts of South Africa. Nine biological traits (associated with life history, morphology and behavioural characteristics exhibited by each species) were classified into 39 modalities and weighted with biomass. Community Weighted Means (CWMs) were used to evaluate the benthic epifaunal functional trait composition of the 13 biogeographic ecotypes. Functional composition across the 13 ecotype assemblages on the west and south coast appeared to be dominated by species with similar trait compositions, such as large, long-lived, surface crawling/burrowing/filter-feeding epifauna with medium to no mobility, however, their percentage of contribution to trait expression (CWMs) was higher on the west coast. Functional diversity indices (alpha and beta) showed higher overall FD for west coast ecotypes, with most ecotypes on the continental shelf (except slopes and canyons) being significantly different (p<0.05) from ecotypes on the south coast. The global RLQ (three-table co-inertia) test did not reveal a significant relationship between biomass and physical variables or between biomass and traits (p>0.05). The fourth-corner method was used to test the significance of individual traitenvironment relationships. The fourth-corner results were similar overall to the RLQ analysis, revealing that three physical variables (temperature, depth, and fluorescence) were significantly correlated to two trait modalities belonging to the feeding mode filter-feeders (FM1) and scavengers (FM5). Scavengers were positively correlated with depth and negatively with temperature, while filter-feeders were positively correlated with fluorescence levels. This indicated that the presence of scavenging epifauna increased with a decrease in temperature and an increase in depth. While a positive significant correlation between filter-feeders and fluorescence suggested their potential tolerance or preference for environmental conditions with high levels of fluorescence. This research was the first such study to explore the functional composition and diversity of benthic epifauna and their relationship with potential physical drivers in offshore west and south coast benthic biogeographic ecotypes of South Africa. The application of new tools to quantify the functional diversity of epifauna as indicators of ecosystem health, and their potential physical drivers. This provided a platform on which to advance our understanding of benthic communities and the roles they play in ecosystem functioning under changing environments. Functional trait-based approaches such as those applied in this study can provide us with vital information on the relationship between biodiversity, ecosystem functioning, and physical drivers. Environmental stressors and changing climate patterns threaten to impact marine ecosystems and their functioning. Benthic epifauna are especially sensitive to changes in their environment and these fluctuations could potentially lead to the loss of certain benthic functionality, altering the thresholds these ecosystems have to response to disturbances. This undermines the stability of these ecosystems which can have ripple effects on the health of these ecosystems and their ability to provide the ecosystem services humans dependent on. Having suitable tools to track current and predict future changes will therefore be vital to inform management and conservation strategies for sustainable ocean utilisation. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2023
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  • Date Issued: 2023-12
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