Identifying a Successful Accounting Student: Profiling of Postgraduate Accounting Students in the Eastern Cape
- Authors: Weldon, Lana Joy
- Date: 2020
- Subjects: Personality -- South Africa -- Eastern Cape , Accounting -- Study and teaching (Higher) -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50699 , vital:42343
- Description: Throughput rates and transformation have long been considered major challenges to accounting departments in South Africa. While much research has been done on various aspects of study techniques in an attempt to assist students to succeed, little attention has been paid to profiling students to ascertain whether there are common traits in terms of personality, aptitude, values and motives, which distinguish successful students from others. This study looks at these factors and uses sub-tests of the Differential Aptitude Test (DAT), selected with reference to the South African Institute of Chartered Accountants (SAICA) Competency Framework, to determine the correlation between these aptitudes and the success of accounting students. In addition, the impact of biographical data, including gender, race and type of school attended, is considered on the success of the students and the individual sub-tests of aptitude. The study then considers the impact of various personality types, personality traits and values on the success or failure of accounting students, and finally seeks to ascertain whether there is a holistic profile of a student who has a statistically significant chance of succeeding in accounting studies. Results indicate that the sub-tests of aptitude for verbal reasoning and reading comprehension have the most significance in predicting student success and that gender and race have a medium effect. Furthermore, personality types, personality traits and values do not have a significant impact on student success. The only biographical factor to have an impact on success was race. Despite the findings in the individual factors considered, no distinct personality profile of a successful Results indicate that the sub-tests of aptitude for verbal reasoning and reading comprehension have the most significance in predicting student success and that gender and race have a medium effect. Furthermore, personality types, personality traits and values do not have a significant impact on student success. The only biographical factor to have an impact on success was race. Despite the findings in the individual factors considered, no distinct personality profile of a successful accounting student emerged. Future research on the use of literacy competency assessments in the admission requirements for chartered accounting programmes, or to inform student academic support initiatives is recommended. accounting student emerged. Future research on the use of literacy competency assessments in the admission requirements for chartered accounting programmes, or to inform student academic support initiatives is recommended.
- Full Text:
- Date Issued: 2020
- Authors: Weldon, Lana Joy
- Date: 2020
- Subjects: Personality -- South Africa -- Eastern Cape , Accounting -- Study and teaching (Higher) -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50699 , vital:42343
- Description: Throughput rates and transformation have long been considered major challenges to accounting departments in South Africa. While much research has been done on various aspects of study techniques in an attempt to assist students to succeed, little attention has been paid to profiling students to ascertain whether there are common traits in terms of personality, aptitude, values and motives, which distinguish successful students from others. This study looks at these factors and uses sub-tests of the Differential Aptitude Test (DAT), selected with reference to the South African Institute of Chartered Accountants (SAICA) Competency Framework, to determine the correlation between these aptitudes and the success of accounting students. In addition, the impact of biographical data, including gender, race and type of school attended, is considered on the success of the students and the individual sub-tests of aptitude. The study then considers the impact of various personality types, personality traits and values on the success or failure of accounting students, and finally seeks to ascertain whether there is a holistic profile of a student who has a statistically significant chance of succeeding in accounting studies. Results indicate that the sub-tests of aptitude for verbal reasoning and reading comprehension have the most significance in predicting student success and that gender and race have a medium effect. Furthermore, personality types, personality traits and values do not have a significant impact on student success. The only biographical factor to have an impact on success was race. Despite the findings in the individual factors considered, no distinct personality profile of a successful Results indicate that the sub-tests of aptitude for verbal reasoning and reading comprehension have the most significance in predicting student success and that gender and race have a medium effect. Furthermore, personality types, personality traits and values do not have a significant impact on student success. The only biographical factor to have an impact on success was race. Despite the findings in the individual factors considered, no distinct personality profile of a successful accounting student emerged. Future research on the use of literacy competency assessments in the admission requirements for chartered accounting programmes, or to inform student academic support initiatives is recommended. accounting student emerged. Future research on the use of literacy competency assessments in the admission requirements for chartered accounting programmes, or to inform student academic support initiatives is recommended.
- Full Text:
- Date Issued: 2020
Identifying the causes of widespread illegal dumping in Buffalo City Metropolitan Municipality and innovative waste management mechanism
- Authors: Brown, Drayton
- Date: 2020
- Subjects: Waste minimization -- law and legislation -- South Africa -- Buffalo City Metropolitan Municipality
- Language: English
- Type: Thesis , Masters , Degree
- Identifier: http://hdl.handle.net/10948/49767 , vital:41798
- Description: South Africa faces the daily challenge of illegal dumping and authorities cannot seem to contain the problem. This is particularly the case in Buffalo City Metropolitan Municipality (BCMM) as the same non-effective means of curbing illegal dumping is attempted again and again. This study sought to gain insight into why residents would illegally dump waste near their homes considering the numerous negative health and environmental consequences. While many studies have focused on the quantitative aspects of waste management and illegal dumping, none have been conducted in the Eastern Cape or BCMM or enquired as to how citizens felt about the phenomena. This research utilised in-depth semi-structured interviews to gain insight into the problem of illegal dumping through the lenses of both residents and BCMM staff members. One of the key themes within the findings of the study is the apathetic nature of citizens towards their environment. There are also two predominant ways illegal dumping sites form. The first is through ‘Systemic Dumping’ which arises through the lack of waste infrastructure in low income communities and the second is ‘Ad-hoc Illegal Dumping’which form when BCMM does not provide a timely waste management service.
- Full Text:
- Date Issued: 2020
- Authors: Brown, Drayton
- Date: 2020
- Subjects: Waste minimization -- law and legislation -- South Africa -- Buffalo City Metropolitan Municipality
- Language: English
- Type: Thesis , Masters , Degree
- Identifier: http://hdl.handle.net/10948/49767 , vital:41798
- Description: South Africa faces the daily challenge of illegal dumping and authorities cannot seem to contain the problem. This is particularly the case in Buffalo City Metropolitan Municipality (BCMM) as the same non-effective means of curbing illegal dumping is attempted again and again. This study sought to gain insight into why residents would illegally dump waste near their homes considering the numerous negative health and environmental consequences. While many studies have focused on the quantitative aspects of waste management and illegal dumping, none have been conducted in the Eastern Cape or BCMM or enquired as to how citizens felt about the phenomena. This research utilised in-depth semi-structured interviews to gain insight into the problem of illegal dumping through the lenses of both residents and BCMM staff members. One of the key themes within the findings of the study is the apathetic nature of citizens towards their environment. There are also two predominant ways illegal dumping sites form. The first is through ‘Systemic Dumping’ which arises through the lack of waste infrastructure in low income communities and the second is ‘Ad-hoc Illegal Dumping’which form when BCMM does not provide a timely waste management service.
- Full Text:
- Date Issued: 2020
Identifying the causes of widespread illegal dumping in buffalo city metropolitan municipality and innovative waste management mechanisms
- Authors: Brown, Drayton
- Date: 2020
- Subjects: Refuse and refuse disposal -- South Africa -- Eastern Cape , Municipal Services -- South Africa -- Eastern Cape Waste minimization -- South Africa -- Buffalo City Metropolitan Municipality
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/50444 , vital:42168
- Description: South Africa faces the daily challenge of illegal dumping and authorities cannot seem to contain the problem. This is particularly the case in Buffalo City Metropolitan Municipality (BCMM) as the same non-effective means of curbing illegal dumping is attempted again and again. This study sought to gain insight into why residents would illegally dump waste near their homes considering the numerous negative health and environmental consequences. While many studies have focused on the quantitative aspects of waste management and illegal dumping, none have been conducted in the Eastern Cape or BCMM or enquired as to how citizens felt about the phenomena. This research utilised in-depth semi-structured interviews to gain insight into the problem of illegal dumping through the lenses of both residents and BCMM staff members. One of the key themes within the findings of the study is the apathetic nature of citizens towards their environment. There are also two predominant ways illegal dumping sites form. The first is through ‘Systemic Dumping’ which arises through the lack of waste infrastructure in low income communities and the second is ‘Ad-hoc Illegal Dumping’ which form when BCMM does not provide a timely waste management service.
- Full Text:
- Date Issued: 2020
- Authors: Brown, Drayton
- Date: 2020
- Subjects: Refuse and refuse disposal -- South Africa -- Eastern Cape , Municipal Services -- South Africa -- Eastern Cape Waste minimization -- South Africa -- Buffalo City Metropolitan Municipality
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/50444 , vital:42168
- Description: South Africa faces the daily challenge of illegal dumping and authorities cannot seem to contain the problem. This is particularly the case in Buffalo City Metropolitan Municipality (BCMM) as the same non-effective means of curbing illegal dumping is attempted again and again. This study sought to gain insight into why residents would illegally dump waste near their homes considering the numerous negative health and environmental consequences. While many studies have focused on the quantitative aspects of waste management and illegal dumping, none have been conducted in the Eastern Cape or BCMM or enquired as to how citizens felt about the phenomena. This research utilised in-depth semi-structured interviews to gain insight into the problem of illegal dumping through the lenses of both residents and BCMM staff members. One of the key themes within the findings of the study is the apathetic nature of citizens towards their environment. There are also two predominant ways illegal dumping sites form. The first is through ‘Systemic Dumping’ which arises through the lack of waste infrastructure in low income communities and the second is ‘Ad-hoc Illegal Dumping’ which form when BCMM does not provide a timely waste management service.
- Full Text:
- Date Issued: 2020
Impact of change management on employee engagement
- Authors: Moche, Boitshoko
- Date: 2020
- Subjects: Personnel management Organizational change
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/49703 , vital:41772
- Description: Change is inevitable and change is necessary; in order for organisations to remain competitive they have to keep on evolving, ensuring that the organisational vision and strategy are aligned to the organisation’s vision, importantly, that the employees have a fulfilling work experience in order to do their best and live up to the organisation’s values. In the high-pressured, agile work environment, it is necessary for the organisations to move their processes with the times, providing information on digital platforms while upskilling the employees and saving time. Employee engagement is defined as the force that drives the organisational success and when achieved it eventually leads to high morale, employee retention, employee trust and loyalty to the organisation and organisational performance The aim of the study was to investigate the impact of change management process on the employee engagement in the workplace. The three identified main factors were readiness for change, process of change and leadership involvement. Change initiatives have been reported to fail by 70% if not implemented effectively and can have a negative impact on how the employees receive the change. The mixed method study approach was used, starting with interviews with the four key players in the organisation to establish how they perceive change and gather new information. It was followed by a quantitative e-survey to departments which have had technological change in the past year. The empirical results showed that the there is a relationship between the factors of change and employee engagement. Importance of readiness for change was highlighted, supporting the need for an organisational analysis followed by a detailed change plan aligned to the organisational vision. Process of change had a positive significance for employee engagement while lack of leadership involvement showed the negative relationship to employee engagement. The findings show how change leadership should work in sync with organisational leadership at all times and should incorporate change management into the organisational DNA.
- Full Text:
- Date Issued: 2020
- Authors: Moche, Boitshoko
- Date: 2020
- Subjects: Personnel management Organizational change
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/49703 , vital:41772
- Description: Change is inevitable and change is necessary; in order for organisations to remain competitive they have to keep on evolving, ensuring that the organisational vision and strategy are aligned to the organisation’s vision, importantly, that the employees have a fulfilling work experience in order to do their best and live up to the organisation’s values. In the high-pressured, agile work environment, it is necessary for the organisations to move their processes with the times, providing information on digital platforms while upskilling the employees and saving time. Employee engagement is defined as the force that drives the organisational success and when achieved it eventually leads to high morale, employee retention, employee trust and loyalty to the organisation and organisational performance The aim of the study was to investigate the impact of change management process on the employee engagement in the workplace. The three identified main factors were readiness for change, process of change and leadership involvement. Change initiatives have been reported to fail by 70% if not implemented effectively and can have a negative impact on how the employees receive the change. The mixed method study approach was used, starting with interviews with the four key players in the organisation to establish how they perceive change and gather new information. It was followed by a quantitative e-survey to departments which have had technological change in the past year. The empirical results showed that the there is a relationship between the factors of change and employee engagement. Importance of readiness for change was highlighted, supporting the need for an organisational analysis followed by a detailed change plan aligned to the organisational vision. Process of change had a positive significance for employee engagement while lack of leadership involvement showed the negative relationship to employee engagement. The findings show how change leadership should work in sync with organisational leadership at all times and should incorporate change management into the organisational DNA.
- Full Text:
- Date Issued: 2020
Impact of climate finance on environmental quality in Sub-Sahara Africa
- Authors: Doku, Isaac
- Date: 2020
- Subjects: Climatic changes -- Economic aspects , Economic development -- Environmental aspects Macroeconomics -- Econometric models
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50513 , vital:42206
- Description: Most climate finances available to Sub-Sahara Africa countries tries to assist governmental and non-governmental institutions decarbonise by reducing greenhouse gases or promote conservation of forests through REDD+ programs. On that backdrop, three main general objectives arises for this study; (1) to examine the impact of climate finance on greenhouse gas emissions (2) To find the impact of climate finance on deforestation in Sub-Sahara Africa (3) To determine the major recipient characteristics that attracts more climate finance to Sub-Sahara Africa. The first general objective looked at three greenhouse gas variables; carbon emission, methane and nitrous oxide emission. Data was analysed using system GMM for all countries in Sub-Sahara Africa for the period 2006-2017 based on data availability. The first general objective of the study employed system GMM robust standard errors and triangulates the result by using DOLS and FMOLS for robustness check. The findings show that climate finance is not reducing nitrous oxide, methane and total greenhouse gas emissions into the atmosphere, whereas carbon emission showed mixed results. System GMM results affirmed the existence of EKC, but DOLS and FMOLS results gave a contradictory finding. Based on that, we cannot conclude the existence of EKC for our studies. Energy consumption showed a positive significant impact on carbon, methane and total greenhouse gas for all three models in accordance to prior studies and affirming pollution haven hypothesis, but a mixed result for nitrous oxide. Finally, the findings from governance readiness showed governments in Africa’s unwillingness to reduce carbon but very keen in reducing the other greenhouses gases for all three models. Existence of pollution haven hypothesis shows that more hazardous and dirty investments are moving from developed countries to developing countries with less strict environmental rules like Sub-Sahara Africa. The second and third general objectives of the study employed system-GMM estimation technique to take care of time series variations in the data, as well as capture the unobserved country-specific time-invariant effect. Three and four stages hierarchical regressions are carried out for objectives two and three respectively and a panel quantile regression is employed to test sensitivity of the results for both analysis. The findings for objective two showed that increase in climate climate finance increases deforestation in two models and one model showing a decrease in deforestation, making the result very difficult to interpret and mixed. The study did not also get support for EKC but indicated that forest transition curve is rather U-shaped for all countries in Sub-Sahara Africa and two sub-regional blocks; EAC and CEMAC. Population growth and agricultural land use have been found to be major drivers of deforestation. Most of the governance indicators showed adverse impact on deforestation. The result for objective three indicates that Sub-Sahara African countries with high population growth rate, higher poverty levels, better ease of doing business profile, weaker governance policies, weaker control of corruption, stronger rule of law enforcement, deepened social inequality and better ICT usage have attracted more climate finance. Based on that, we recommend Africa countries to strengthen their practice of rule of law and more stringent rules to prevent or minimize corruption in the system. Climate finance managers should also undertake rigorous monitoring and supervision when funds are extended to reduce misappropriation of funds by recipients.
- Full Text:
- Date Issued: 2020
- Authors: Doku, Isaac
- Date: 2020
- Subjects: Climatic changes -- Economic aspects , Economic development -- Environmental aspects Macroeconomics -- Econometric models
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50513 , vital:42206
- Description: Most climate finances available to Sub-Sahara Africa countries tries to assist governmental and non-governmental institutions decarbonise by reducing greenhouse gases or promote conservation of forests through REDD+ programs. On that backdrop, three main general objectives arises for this study; (1) to examine the impact of climate finance on greenhouse gas emissions (2) To find the impact of climate finance on deforestation in Sub-Sahara Africa (3) To determine the major recipient characteristics that attracts more climate finance to Sub-Sahara Africa. The first general objective looked at three greenhouse gas variables; carbon emission, methane and nitrous oxide emission. Data was analysed using system GMM for all countries in Sub-Sahara Africa for the period 2006-2017 based on data availability. The first general objective of the study employed system GMM robust standard errors and triangulates the result by using DOLS and FMOLS for robustness check. The findings show that climate finance is not reducing nitrous oxide, methane and total greenhouse gas emissions into the atmosphere, whereas carbon emission showed mixed results. System GMM results affirmed the existence of EKC, but DOLS and FMOLS results gave a contradictory finding. Based on that, we cannot conclude the existence of EKC for our studies. Energy consumption showed a positive significant impact on carbon, methane and total greenhouse gas for all three models in accordance to prior studies and affirming pollution haven hypothesis, but a mixed result for nitrous oxide. Finally, the findings from governance readiness showed governments in Africa’s unwillingness to reduce carbon but very keen in reducing the other greenhouses gases for all three models. Existence of pollution haven hypothesis shows that more hazardous and dirty investments are moving from developed countries to developing countries with less strict environmental rules like Sub-Sahara Africa. The second and third general objectives of the study employed system-GMM estimation technique to take care of time series variations in the data, as well as capture the unobserved country-specific time-invariant effect. Three and four stages hierarchical regressions are carried out for objectives two and three respectively and a panel quantile regression is employed to test sensitivity of the results for both analysis. The findings for objective two showed that increase in climate climate finance increases deforestation in two models and one model showing a decrease in deforestation, making the result very difficult to interpret and mixed. The study did not also get support for EKC but indicated that forest transition curve is rather U-shaped for all countries in Sub-Sahara Africa and two sub-regional blocks; EAC and CEMAC. Population growth and agricultural land use have been found to be major drivers of deforestation. Most of the governance indicators showed adverse impact on deforestation. The result for objective three indicates that Sub-Sahara African countries with high population growth rate, higher poverty levels, better ease of doing business profile, weaker governance policies, weaker control of corruption, stronger rule of law enforcement, deepened social inequality and better ICT usage have attracted more climate finance. Based on that, we recommend Africa countries to strengthen their practice of rule of law and more stringent rules to prevent or minimize corruption in the system. Climate finance managers should also undertake rigorous monitoring and supervision when funds are extended to reduce misappropriation of funds by recipients.
- Full Text:
- Date Issued: 2020
Impact of digital age on street traders in Buffalo City and preparation for future economic activity
- Authors: Mkonwana, Siyasanga Phiwe
- Date: 2020
- Subjects: LCSH LCSH
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/49681 , vital:41770
- Description: The study was focusing on the street trading as a form of informal trade in Buffalo City, and how the digital age has impacted on the street traders. Street trading is a form of informal trade that takes place in many developing countries. It is mostly located in urban areas, towns and cities where there is foot traffic. Traditionally, street trading has not been recognised as contributing to the economy of a country (Robinson, 2002). The lack of economic acknowledgement has led to street trading issues being largely ignored or referred to urban managers (Lyons and Snoxell, 2005). Digitalisation has shifted the world’s paradigm and has impacted the business and its operations. The world is currently in the ‘digital age’, where everything is done (or will soon be done) through the use of technology such as cell phones, the internet of things (IoT), driverless cars, and three-dimensional (3D) technology (WEF, 2018). Technology also promote continuous new invention and innovation (World Trade Report [WTR], 2017). In the workplace, digitisation is estimated to have an increasingly negative impact on the labour market in the developing countries, leading to higher unemployment rates and low productivity (UNCTA, 2016). Semi-structured focused interviews were used to collect data for the research from 10 street traders in the BCMM area of the Eastern Cape, South Africa. The interviews were undertaken between November 2018 and January 2019. There are two predominant paradigms used for the research, namely the constructivist/ interpretative and the positivist/post-positivist paradigms (Cillisa, 2011). Data analysis was done through linking the empirical data to the propositions and interpretations were done in the last chapter.
- Full Text:
- Date Issued: 2020
Impact of digital age on street traders in Buffalo City and preparation for future economic activity
- Authors: Mkonwana, Siyasanga Phiwe
- Date: 2020
- Subjects: LCSH LCSH
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/49681 , vital:41770
- Description: The study was focusing on the street trading as a form of informal trade in Buffalo City, and how the digital age has impacted on the street traders. Street trading is a form of informal trade that takes place in many developing countries. It is mostly located in urban areas, towns and cities where there is foot traffic. Traditionally, street trading has not been recognised as contributing to the economy of a country (Robinson, 2002). The lack of economic acknowledgement has led to street trading issues being largely ignored or referred to urban managers (Lyons and Snoxell, 2005). Digitalisation has shifted the world’s paradigm and has impacted the business and its operations. The world is currently in the ‘digital age’, where everything is done (or will soon be done) through the use of technology such as cell phones, the internet of things (IoT), driverless cars, and three-dimensional (3D) technology (WEF, 2018). Technology also promote continuous new invention and innovation (World Trade Report [WTR], 2017). In the workplace, digitisation is estimated to have an increasingly negative impact on the labour market in the developing countries, leading to higher unemployment rates and low productivity (UNCTA, 2016). Semi-structured focused interviews were used to collect data for the research from 10 street traders in the BCMM area of the Eastern Cape, South Africa. The interviews were undertaken between November 2018 and January 2019. There are two predominant paradigms used for the research, namely the constructivist/ interpretative and the positivist/post-positivist paradigms (Cillisa, 2011). Data analysis was done through linking the empirical data to the propositions and interpretations were done in the last chapter.
- Full Text:
- Date Issued: 2020
Impact of early pandemic stage mutations on molecular dynamics of SARS-CoV-2 Mpro:
- Sheik Amamuddy, Olivier, Verkhivker, Gennady M, Tastan Bishop, Özlem
- Authors: Sheik Amamuddy, Olivier , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162330 , vital:40835 , https://0-doi.org.wam.seals.ac.za/10.1021/acs.jcim.0c00634
- Description: A new coronavirus (SARS-CoV-2) is a global threat to world health and economy. Its dimeric main protease (Mpro), which is required for the proteolytic cleavage of viral precursor proteins, is a good candidate for drug development owing to its conservation and the absence of a human homolog. Improving our understanding of Mpro behavior can accelerate the discovery of effective therapies to reduce mortality. All-atom molecular dynamics (MD) simulations (100 ns) of 50 mutant Mpro dimers obtained from filtered sequences from the GISAID database were analyzed using root-mean-square deviation, root-mean-square fluctuation, Rg, averaged betweenness centrality, and geometry calculations.
- Full Text:
- Date Issued: 2020
- Authors: Sheik Amamuddy, Olivier , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162330 , vital:40835 , https://0-doi.org.wam.seals.ac.za/10.1021/acs.jcim.0c00634
- Description: A new coronavirus (SARS-CoV-2) is a global threat to world health and economy. Its dimeric main protease (Mpro), which is required for the proteolytic cleavage of viral precursor proteins, is a good candidate for drug development owing to its conservation and the absence of a human homolog. Improving our understanding of Mpro behavior can accelerate the discovery of effective therapies to reduce mortality. All-atom molecular dynamics (MD) simulations (100 ns) of 50 mutant Mpro dimers obtained from filtered sequences from the GISAID database were analyzed using root-mean-square deviation, root-mean-square fluctuation, Rg, averaged betweenness centrality, and geometry calculations.
- Full Text:
- Date Issued: 2020
Impact of emerging mutations on the dynamic properties the SARS-CoV-2 main protease: an in silico investigation
- Sheik Amamuddy, Olivier, Verkhivker, Gennady M, Tastan Bishop, Özlem
- Authors: Sheik Amamuddy, Olivier , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163035 , vital:41006 , doi: 10.1021/acs.jcim.0c00634
- Description: The new coronavirus (SARS-CoV-2) is a global threat to world health and its economy. Its main protease (Mpro), which functions as a dimer, cleaves viral precursor proteins in the process of viral maturation. It is a good candidate for drug development owing to its conservation and the absence of a human homolog. An improved understanding of the protein behaviour can accelerate the discovery of effective therapies in order to reduce mortality. 100 ns all-atom molecular dynamics simulations of 50 homology modelled mutant Mpro dimers were performed at pH 7 from filtered sequences obtained from the GISAID database. Protease dynamics were analysed using RMSD, RMSF, Rg, the averaged betweenness centrality and geometry calculations. Domains from each Mpro protomer were found to generally have independent motions, while the dimer-stabilising N-finger region was found to be flexible in most mutants.
- Full Text:
- Date Issued: 2020
- Authors: Sheik Amamuddy, Olivier , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163035 , vital:41006 , doi: 10.1021/acs.jcim.0c00634
- Description: The new coronavirus (SARS-CoV-2) is a global threat to world health and its economy. Its main protease (Mpro), which functions as a dimer, cleaves viral precursor proteins in the process of viral maturation. It is a good candidate for drug development owing to its conservation and the absence of a human homolog. An improved understanding of the protein behaviour can accelerate the discovery of effective therapies in order to reduce mortality. 100 ns all-atom molecular dynamics simulations of 50 homology modelled mutant Mpro dimers were performed at pH 7 from filtered sequences obtained from the GISAID database. Protease dynamics were analysed using RMSD, RMSF, Rg, the averaged betweenness centrality and geometry calculations. Domains from each Mpro protomer were found to generally have independent motions, while the dimer-stabilising N-finger region was found to be flexible in most mutants.
- Full Text:
- Date Issued: 2020
Impact of fracking fluid on Karoo plants based on field and greenhouse experiments
- Authors: Liddell, Duncan Carlyle
- Date: 2020
- Subjects: Plants -- South Africa -- Little Karoo , Desert ecology -- South Africa Great Karoo (South Africa)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/49125 , vital:41603
- Description: Fracking fluid has been indicated to be detrimental to vegetation. In forest vegetation the fracking fluid caused ground vegetation to be extensively damaged with high mortality rates and trees showing premature leaf loss following application. A study by Martin (2017) investigated these effects on Karoo vegetation in a greenhouse and found it to increase stress and reduced the growth with some life forms being identified as sensitive. The current study followed on the work of Martin testing additional species in the same greenhouse and applying different treatments of fracking fluid to Karoo vegetation in their habitat. The plants were monitored by measuring their height, photosynthetic efficiency (stress), biomass allocation and the temperature of the sites. The greenhouse plants had increased growth associated with repeated fracking fluid treatments while having variable stress levels with different treatments of the fracking fluid. The farm had mixed results being generally more stressed due to the treatments, the repeated fracking fluid treatments showed greater growth. The farm vegetation was more sensitive due to prolonged drought which is suspected to play a large role in the different response to fracking fluid between the two sites. The several hypotheses based on the finding of Martin (2017) were not supported by the data in this study. However, the application of fracking fluid did affect the tree species as they were found to be sensitive, while the other plant species was generally stressed after the applications. The greenhouse study cannot accurately represent the effects of fracking fluid on the farm vegetation, due to the large difference in the environment thus, more field studies would need to be conducted to determine the effects of fracking fluid.
- Full Text:
- Date Issued: 2020
- Authors: Liddell, Duncan Carlyle
- Date: 2020
- Subjects: Plants -- South Africa -- Little Karoo , Desert ecology -- South Africa Great Karoo (South Africa)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/49125 , vital:41603
- Description: Fracking fluid has been indicated to be detrimental to vegetation. In forest vegetation the fracking fluid caused ground vegetation to be extensively damaged with high mortality rates and trees showing premature leaf loss following application. A study by Martin (2017) investigated these effects on Karoo vegetation in a greenhouse and found it to increase stress and reduced the growth with some life forms being identified as sensitive. The current study followed on the work of Martin testing additional species in the same greenhouse and applying different treatments of fracking fluid to Karoo vegetation in their habitat. The plants were monitored by measuring their height, photosynthetic efficiency (stress), biomass allocation and the temperature of the sites. The greenhouse plants had increased growth associated with repeated fracking fluid treatments while having variable stress levels with different treatments of the fracking fluid. The farm had mixed results being generally more stressed due to the treatments, the repeated fracking fluid treatments showed greater growth. The farm vegetation was more sensitive due to prolonged drought which is suspected to play a large role in the different response to fracking fluid between the two sites. The several hypotheses based on the finding of Martin (2017) were not supported by the data in this study. However, the application of fracking fluid did affect the tree species as they were found to be sensitive, while the other plant species was generally stressed after the applications. The greenhouse study cannot accurately represent the effects of fracking fluid on the farm vegetation, due to the large difference in the environment thus, more field studies would need to be conducted to determine the effects of fracking fluid.
- Full Text:
- Date Issued: 2020
Impacts of a trophy hunting ban on private land conservation in South African biodiversity hotspots:
- Parker, Kim, de Vos, Alta, Clements, Hayley S, Biggs, Duan, Biggs, Reinette
- Authors: Parker, Kim , de Vos, Alta , Clements, Hayley S , Biggs, Duan , Biggs, Reinette
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158219 , vital:40163 , https://0-doi.org.wam.seals.ac.za/10.1111/csp2.214
- Description: Private land conservation areas (PLCAs) have become critical for achieving global conservation goals, but we lack understanding of how and when these areas respond to global pressures and opportunities. In southern Africa, where many PLCAs rely on trophy hunting as an income‐generating strategy, a potential ban on trophy hunting locally or abroad holds unknown consequences for the future conservation of these lands. In this study, we investigate the consequences of a potential trophy hunting ban in PLCAs in two biodiversity hotspots in South Africa's Eastern and Western Cape provinces. We used semistructured interviews with PLCA managers and owners to elicit perceived impacts of an internationally imposed trophy hunting ban on conservation activities in PLCAs, and to probe alternative viable land uses.
- Full Text:
- Date Issued: 2020
Impacts of a trophy hunting ban on private land conservation in South African biodiversity hotspots:
- Authors: Parker, Kim , de Vos, Alta , Clements, Hayley S , Biggs, Duan , Biggs, Reinette
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158219 , vital:40163 , https://0-doi.org.wam.seals.ac.za/10.1111/csp2.214
- Description: Private land conservation areas (PLCAs) have become critical for achieving global conservation goals, but we lack understanding of how and when these areas respond to global pressures and opportunities. In southern Africa, where many PLCAs rely on trophy hunting as an income‐generating strategy, a potential ban on trophy hunting locally or abroad holds unknown consequences for the future conservation of these lands. In this study, we investigate the consequences of a potential trophy hunting ban in PLCAs in two biodiversity hotspots in South Africa's Eastern and Western Cape provinces. We used semistructured interviews with PLCA managers and owners to elicit perceived impacts of an internationally imposed trophy hunting ban on conservation activities in PLCAs, and to probe alternative viable land uses.
- Full Text:
- Date Issued: 2020
Impacts of cattle grazing pressure on vegetation and soil characteristics in an arid grassland of South Africa
- Authors: Botha, Gert Stephanus
- Date: 2020
- Subjects: Grazing -- Environmental aspects -- South Africa , Cattle -- Feeding and feeds -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/${Handle} , vital:39749
- Description: Natural rangelands are often degraded due to the implementation of incorrect grazing systems. One potential solution is the use of short duration, high intensity grazing. The impacts of this grazing system on, inter alia, vegetation and soil properties have not yet been comprehensively tested within the arid rangelands of South Africa. This study aimed to determine the impacts of grazing intensity on vegetation composition, forage quantity and quality, and soil compaction, soil water infiltration rates and soil chemical properties in an arid grassland in South Africa. The following three grazing treatments were compared: no grazing (NG), low intensity grazing (LIG) and high intensity grazing (HIG). A total of 18 plots (six replicates per treatment) were grazed with Bonsmara cattle. Each plot, 4 ha in size, was surveyed pre-grazing, directly after grazing, and again three, six and 12 months post-grazing. The results indicated that different grazing intensities did not affect grass diversity and the veld condition a year after grazing. Phytomass was influenced by grazing intensity, with no grazing having the highest phytomass throughout the study period. Soil compaction differed among seasons but not among treatments, with summer surveys recording the lowest soil compaction rates. The soil water infiltration rates did not differ between the three different treatments, indicating that grazing intensity did not affect infiltration rates. However, grazing did seem to improve soil nutrient levels when compared to NG. The grazed treatments had higher NH4+, K+, and organic carbon than the NG treatment. Nevertheless, there was no significant difference in nutrients levels when comparing the LIG system to the HIG system. When comparing the soil nutrients levels within a treatment over time, only the HIG treatment showed an increase in soil nutrient levels (Mg2+) over time, whereas the LIG and NG treatments showed no changed throughout the study period. Generally, the study results indicated that in the short term there was no advantage to using higher grazing intensity, although the presence of grazing (as opposed to no grazing) is advantageous to arid grassland functioning.
- Full Text:
- Date Issued: 2020
- Authors: Botha, Gert Stephanus
- Date: 2020
- Subjects: Grazing -- Environmental aspects -- South Africa , Cattle -- Feeding and feeds -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/${Handle} , vital:39749
- Description: Natural rangelands are often degraded due to the implementation of incorrect grazing systems. One potential solution is the use of short duration, high intensity grazing. The impacts of this grazing system on, inter alia, vegetation and soil properties have not yet been comprehensively tested within the arid rangelands of South Africa. This study aimed to determine the impacts of grazing intensity on vegetation composition, forage quantity and quality, and soil compaction, soil water infiltration rates and soil chemical properties in an arid grassland in South Africa. The following three grazing treatments were compared: no grazing (NG), low intensity grazing (LIG) and high intensity grazing (HIG). A total of 18 plots (six replicates per treatment) were grazed with Bonsmara cattle. Each plot, 4 ha in size, was surveyed pre-grazing, directly after grazing, and again three, six and 12 months post-grazing. The results indicated that different grazing intensities did not affect grass diversity and the veld condition a year after grazing. Phytomass was influenced by grazing intensity, with no grazing having the highest phytomass throughout the study period. Soil compaction differed among seasons but not among treatments, with summer surveys recording the lowest soil compaction rates. The soil water infiltration rates did not differ between the three different treatments, indicating that grazing intensity did not affect infiltration rates. However, grazing did seem to improve soil nutrient levels when compared to NG. The grazed treatments had higher NH4+, K+, and organic carbon than the NG treatment. Nevertheless, there was no significant difference in nutrients levels when comparing the LIG system to the HIG system. When comparing the soil nutrients levels within a treatment over time, only the HIG treatment showed an increase in soil nutrient levels (Mg2+) over time, whereas the LIG and NG treatments showed no changed throughout the study period. Generally, the study results indicated that in the short term there was no advantage to using higher grazing intensity, although the presence of grazing (as opposed to no grazing) is advantageous to arid grassland functioning.
- Full Text:
- Date Issued: 2020
Impacts of Climate Change in Determining the Ecological Reserve
- Tanner, Jane L, Griffin, Neil J, Slaughter, Andrew R, Mantel, Sukhmani K, Dabula, Pumza, Hughes, Denis A, Wolff, Margaret G
- Authors: Tanner, Jane L , Griffin, Neil J , Slaughter, Andrew R , Mantel, Sukhmani K , Dabula, Pumza , Hughes, Denis A , Wolff, Margaret G
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/438128 , vital:73437 , ISBN 978-0-6392-0124-5 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/2834 final.pdf
- Description: The intermediate and long-term impacts of climate change require evaluation of the adaptive capacity of the riverine ecosystems to pro-mote sustainability. The predicted climate change impacts are the moti-vation behind the current research which targets the knowledge gap of the impacts of climate change on the ecological Reserve (or Ecological Water Requirements [EWR]). In order for the Department of Water and Sanitation (DWS) to meet their mandate to protect aquatic ecosystems, given the constraints of climate change, it is necessary to take cogni-sance of the implications of climate change and to make the necessary adjustments and changes to the ecological Reserve determination methodology. These adjustments will help ensure that sufficient water, at the right time, distributed in the right flow pattern and of adequate quality is provided, so that key ecological processes are sustained, and that biotic communities maintain their health and integrity.
- Full Text:
- Date Issued: 2020
- Authors: Tanner, Jane L , Griffin, Neil J , Slaughter, Andrew R , Mantel, Sukhmani K , Dabula, Pumza , Hughes, Denis A , Wolff, Margaret G
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/438128 , vital:73437 , ISBN 978-0-6392-0124-5 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/2834 final.pdf
- Description: The intermediate and long-term impacts of climate change require evaluation of the adaptive capacity of the riverine ecosystems to pro-mote sustainability. The predicted climate change impacts are the moti-vation behind the current research which targets the knowledge gap of the impacts of climate change on the ecological Reserve (or Ecological Water Requirements [EWR]). In order for the Department of Water and Sanitation (DWS) to meet their mandate to protect aquatic ecosystems, given the constraints of climate change, it is necessary to take cogni-sance of the implications of climate change and to make the necessary adjustments and changes to the ecological Reserve determination methodology. These adjustments will help ensure that sufficient water, at the right time, distributed in the right flow pattern and of adequate quality is provided, so that key ecological processes are sustained, and that biotic communities maintain their health and integrity.
- Full Text:
- Date Issued: 2020
Implantation, orientation and validation of a commercially produced heart-rate logger for use in a perciform teleost fish:
- Muller, Cuen, Childs, Amber-Robyn, Duncan, Murray I, Skeeles, Michael R, James, Nicola C, Van der Walt, Kerry-Ann, Winkler, Alexander C, Potts, Warren M
- Authors: Muller, Cuen , Childs, Amber-Robyn , Duncan, Murray I , Skeeles, Michael R , James, Nicola C , Van der Walt, Kerry-Ann , Winkler, Alexander C , Potts, Warren M
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148494 , vital:38744 , doi.org.wam.seals.ac.za/10.1093/conphys/coaa035
- Description: Quantifying how the heart rate of ectothermic organisms responds to environmental conditions (e.g. water temperature) is important information to quantify their sensitivity to environmental change. Heart rate studies have typically been conducted in lab environments where fish are confined. However, commercially available implantable heart rate biologgers provide the opportunity to study free-swimming fish. Our study aimed to determine the applicability of an implantable device, typically used on fusiform-shaped fish (e.g. salmonids), for a perciform fish where morphology and anatomy prevent ventral incisions normally used on fusiform-shaped fish.
- Full Text:
- Date Issued: 2020
- Authors: Muller, Cuen , Childs, Amber-Robyn , Duncan, Murray I , Skeeles, Michael R , James, Nicola C , Van der Walt, Kerry-Ann , Winkler, Alexander C , Potts, Warren M
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148494 , vital:38744 , doi.org.wam.seals.ac.za/10.1093/conphys/coaa035
- Description: Quantifying how the heart rate of ectothermic organisms responds to environmental conditions (e.g. water temperature) is important information to quantify their sensitivity to environmental change. Heart rate studies have typically been conducted in lab environments where fish are confined. However, commercially available implantable heart rate biologgers provide the opportunity to study free-swimming fish. Our study aimed to determine the applicability of an implantable device, typically used on fusiform-shaped fish (e.g. salmonids), for a perciform fish where morphology and anatomy prevent ventral incisions normally used on fusiform-shaped fish.
- Full Text:
- Date Issued: 2020
Implementation of access and benefit-sharing measures has consequences for classical biological control of weeds:
- Silvestri, Luciano, Sosa, Alejandro, Mc Kay, Fernando, Vitorino, Marcello D, Hill, Martin P, Zachariades, Costas, Hight, Stephen, Weyl, Philip S R, Smith, David, Djeddour, Djamila, Mason, Peter G
- Authors: Silvestri, Luciano , Sosa, Alejandro , Mc Kay, Fernando , Vitorino, Marcello D , Hill, Martin P , Zachariades, Costas , Hight, Stephen , Weyl, Philip S R , Smith, David , Djeddour, Djamila , Mason, Peter G
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150285 , vital:38964 , https://link.springer.com/article/10.1007/s10526-019-09988-4
- Description: The Convention on Biological Diversity and the Nagoya Protocol establish that genetic resources shall be accessed only upon the existence of prior informed consent of the country that provides those resources and that benefits arising from their utilization shall be shared. Pursuant to both agreements several countries have adopted regulations on access and benefit-sharing. These regulations have created a challenging obstacle to classical biological control of weeds. This paper reviews the experiences of Argentina, Brazil, South Africa, the USA, Canada and CABI in implementing access and benefit-sharing regulations and the implications these measures have on the effective and efficient access, exchange and utilization of biological control agents.
- Full Text:
- Date Issued: 2020
- Authors: Silvestri, Luciano , Sosa, Alejandro , Mc Kay, Fernando , Vitorino, Marcello D , Hill, Martin P , Zachariades, Costas , Hight, Stephen , Weyl, Philip S R , Smith, David , Djeddour, Djamila , Mason, Peter G
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150285 , vital:38964 , https://link.springer.com/article/10.1007/s10526-019-09988-4
- Description: The Convention on Biological Diversity and the Nagoya Protocol establish that genetic resources shall be accessed only upon the existence of prior informed consent of the country that provides those resources and that benefits arising from their utilization shall be shared. Pursuant to both agreements several countries have adopted regulations on access and benefit-sharing. These regulations have created a challenging obstacle to classical biological control of weeds. This paper reviews the experiences of Argentina, Brazil, South Africa, the USA, Canada and CABI in implementing access and benefit-sharing regulations and the implications these measures have on the effective and efficient access, exchange and utilization of biological control agents.
- Full Text:
- Date Issued: 2020
Implementation of Professional Development Programmes For Grade R Teachers: A case study of four primary schools in Amathole West Education District, Eastern Cape
- Authors: Jumo, Theresa
- Date: 2020
- Subjects: Teachers -- Development -- Eastern Cape -- South Africa Teachers -- Vocational guidance -- Eastern Cape -- South Africa
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10353/11341 , vital:39061
- Description: This study investigated the implementation of Professional Development Programmes for Grade R teachers in four primary schools in Amathole West Education District. The interpretive paradigm was employed in this study because it focused on the teachers’ professional development and their participation in a social learning interaction as community of practice. Furthermore, a qualitative approach was used for the collection of data so as to gain in-depth information on the implementation of professional development programmes. Semi-structured interviews and document analysis were used as a form of collecting data. The participants were purposively selected for the sample of this study and comprised of 4 Principals, 1 Subject Advisor and 4 Teachers. Data analysis was done in line with the research questions, aims and objectives of the study. Through the participants’ answers from schools under study, a transcript was formulated, coded and categorized in view of the implementation of Professional Development Programmes for Grade R teachers. The data revealed that Grade R teachers under study were under qualified such that none of the teachers had the recommended Diploma in Grade R qualification as stated by the Department of Basic Education. It was also found that there was diversity in the teachers’ qualifications, colleges and the length in training. The study also indicated that although professional development programmes were held, these were however not properly monitored. Findings also revealed that the intervention strategies through professional development programmes and the support given by the district and the schools were strategies through professional development programmes and the support given by the district and the schools were not adequate and consistent. As a result the participants encountered a number of challenges regarding the implementation of professional development programmes for Grade R teachers. Namely: (1) lack of appropriately qualified personnel to support the teachers both at school and the district (2) lack of adequate follow up support visits and feedbacks from both the school and the district (3) lack of proper management by the schools and (4) lack of collaboration ii and team work in the schools. Thus, there were variances in schools under study especially with regards to late release of funding for teaching and learning materials, support offered to the principals by the Department of Education. As a result, recommendations from the study suggested that the Department of Education and the District have to come up with more strategies of continuously training the teachers and the principals and offering strong and adequate support. The study also recommended the engagement of NGOs for job embedded professional development with longer in-service training periods as compared to the shot in-service professional development programs of once- off workshops. Also another suggestion that the district must monitor school based professional development programs regularly was raised in the study
- Full Text:
- Date Issued: 2020
- Authors: Jumo, Theresa
- Date: 2020
- Subjects: Teachers -- Development -- Eastern Cape -- South Africa Teachers -- Vocational guidance -- Eastern Cape -- South Africa
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10353/11341 , vital:39061
- Description: This study investigated the implementation of Professional Development Programmes for Grade R teachers in four primary schools in Amathole West Education District. The interpretive paradigm was employed in this study because it focused on the teachers’ professional development and their participation in a social learning interaction as community of practice. Furthermore, a qualitative approach was used for the collection of data so as to gain in-depth information on the implementation of professional development programmes. Semi-structured interviews and document analysis were used as a form of collecting data. The participants were purposively selected for the sample of this study and comprised of 4 Principals, 1 Subject Advisor and 4 Teachers. Data analysis was done in line with the research questions, aims and objectives of the study. Through the participants’ answers from schools under study, a transcript was formulated, coded and categorized in view of the implementation of Professional Development Programmes for Grade R teachers. The data revealed that Grade R teachers under study were under qualified such that none of the teachers had the recommended Diploma in Grade R qualification as stated by the Department of Basic Education. It was also found that there was diversity in the teachers’ qualifications, colleges and the length in training. The study also indicated that although professional development programmes were held, these were however not properly monitored. Findings also revealed that the intervention strategies through professional development programmes and the support given by the district and the schools were strategies through professional development programmes and the support given by the district and the schools were not adequate and consistent. As a result the participants encountered a number of challenges regarding the implementation of professional development programmes for Grade R teachers. Namely: (1) lack of appropriately qualified personnel to support the teachers both at school and the district (2) lack of adequate follow up support visits and feedbacks from both the school and the district (3) lack of proper management by the schools and (4) lack of collaboration ii and team work in the schools. Thus, there were variances in schools under study especially with regards to late release of funding for teaching and learning materials, support offered to the principals by the Department of Education. As a result, recommendations from the study suggested that the Department of Education and the District have to come up with more strategies of continuously training the teachers and the principals and offering strong and adequate support. The study also recommended the engagement of NGOs for job embedded professional development with longer in-service training periods as compared to the shot in-service professional development programs of once- off workshops. Also another suggestion that the district must monitor school based professional development programs regularly was raised in the study
- Full Text:
- Date Issued: 2020
Implementation of safety measures in selected public high schools in the Alfred Nzo East education district
- Authors: Mditshwa, Simbongile
- Date: 2020
- Subjects: Schools -- Security measures School safety and security
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10353/17895 , vital:41975
- Description: The main aim of the study was to find out how safety measures are implemented in selected public high schools in the Alfred Nzo East Education District. The study was motivated by multiple media reports about incidents that have to do with the safety of learners especially in rural public schools. This case study was grounded in the interpretive paradigm and the qualitative approach was adopted. The study was theoretically guided by the principles from both the Street-Level Bureaucracy (SLB) and the Rational Decision Making Model (RDMM). The data was collected from three schools in the Alfred Nzo East Education District, Eastern Cape, RSA. A purposive sampling technique was utilized to choose the research participants. A total of 21 human participants were involved in interviews where two teachers per school, two learners per school, two SGB parents and a principal were interviewed. Interviews were supplemented with short observations and document analysis. The findings of the research include the following: educators get a minimal empowerment to manage school safety in terms of access to school, scholar transport and on. The researched schools had no school-based safety policies. Some of the challenges included the level of roadworthiness of the vehicles that are used to transport school children which exposes learners to a high risk and that puts more pressure on school safety. Drugs and dangerous weapons are other factors which contribute to the instability of school safety. The researcher recommended that educators should be empowered through support from the principals and from the district coordinator through frequent policy implementation conference using online platform to minimize the costs of physical conferences. I recommended that the community must be active whistle-blowers for drug smuggling because drugs in schools emanate from the communities. Indemnity forms, release forms and school-based policies must be made available for implementation and referencing purposes. Schools should establish healthy relationship with external stakeholders like traditional leaders, SAPS and the Department of Social Development to curb lack of safety in schools.
- Full Text:
- Date Issued: 2020
- Authors: Mditshwa, Simbongile
- Date: 2020
- Subjects: Schools -- Security measures School safety and security
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10353/17895 , vital:41975
- Description: The main aim of the study was to find out how safety measures are implemented in selected public high schools in the Alfred Nzo East Education District. The study was motivated by multiple media reports about incidents that have to do with the safety of learners especially in rural public schools. This case study was grounded in the interpretive paradigm and the qualitative approach was adopted. The study was theoretically guided by the principles from both the Street-Level Bureaucracy (SLB) and the Rational Decision Making Model (RDMM). The data was collected from three schools in the Alfred Nzo East Education District, Eastern Cape, RSA. A purposive sampling technique was utilized to choose the research participants. A total of 21 human participants were involved in interviews where two teachers per school, two learners per school, two SGB parents and a principal were interviewed. Interviews were supplemented with short observations and document analysis. The findings of the research include the following: educators get a minimal empowerment to manage school safety in terms of access to school, scholar transport and on. The researched schools had no school-based safety policies. Some of the challenges included the level of roadworthiness of the vehicles that are used to transport school children which exposes learners to a high risk and that puts more pressure on school safety. Drugs and dangerous weapons are other factors which contribute to the instability of school safety. The researcher recommended that educators should be empowered through support from the principals and from the district coordinator through frequent policy implementation conference using online platform to minimize the costs of physical conferences. I recommended that the community must be active whistle-blowers for drug smuggling because drugs in schools emanate from the communities. Indemnity forms, release forms and school-based policies must be made available for implementation and referencing purposes. Schools should establish healthy relationship with external stakeholders like traditional leaders, SAPS and the Department of Social Development to curb lack of safety in schools.
- Full Text:
- Date Issued: 2020
Implementing active surveillance for TB—The views of managers in a resource limited setting, South Africa
- Febisola I. AjuduaID, Robert J. MashID
- Authors: Febisola I. AjuduaID , Robert J. MashID
- Date: 2020
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/4433 , vital:44118
- Full Text:
- Authors: Febisola I. AjuduaID , Robert J. MashID
- Date: 2020
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/4433 , vital:44118
- Full Text:
Implementing prolonged exposure therapy for PTSD in a context of ongoing adversity: a clinical case study
- Booysen, Duane D, Kagee, Ashraf
- Authors: Booysen, Duane D , Kagee, Ashraf
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149275 , vital:38821 , https://0-doi.org.wam.seals.ac.za/10.1177/1534650120925918
- Description: Obstacles regarding the implementation of empirically supported treatments (ESTs) for mental disorders such as post-traumatic stress disorder (PTSD) still require further investigation. One notable obstacle is whether persons in low- and middle-income countries (LMICs) residing in a context of ongoing adversity would benefit from an EST for PTSD. We reflect on the utility of a brief prolonged exposure intervention at a primary care community-counseling center in South Africa. “Sam,” a 45-year-old, female was assessed at baseline, during treatment, postassessment, and at 3-month follow-up. At the beginning of treatment, Sam had a positive diagnosis for PTSD (PSSI-5 = 55, and cutoff is 23) and at the end of treatment (PSSI-5 = 17), and 3-month follow-up (PSSI-5 = 21), she had a negative diagnosis for PTSD. We reflect on the mediating effects that contextual factors such as gang violence had on the treatment process and the feasibility of implementing ESTs for PTSD in LMICs under conditions of ongoing adversity.
- Full Text:
- Date Issued: 2020
- Authors: Booysen, Duane D , Kagee, Ashraf
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149275 , vital:38821 , https://0-doi.org.wam.seals.ac.za/10.1177/1534650120925918
- Description: Obstacles regarding the implementation of empirically supported treatments (ESTs) for mental disorders such as post-traumatic stress disorder (PTSD) still require further investigation. One notable obstacle is whether persons in low- and middle-income countries (LMICs) residing in a context of ongoing adversity would benefit from an EST for PTSD. We reflect on the utility of a brief prolonged exposure intervention at a primary care community-counseling center in South Africa. “Sam,” a 45-year-old, female was assessed at baseline, during treatment, postassessment, and at 3-month follow-up. At the beginning of treatment, Sam had a positive diagnosis for PTSD (PSSI-5 = 55, and cutoff is 23) and at the end of treatment (PSSI-5 = 17), and 3-month follow-up (PSSI-5 = 21), she had a negative diagnosis for PTSD. We reflect on the mediating effects that contextual factors such as gang violence had on the treatment process and the feasibility of implementing ESTs for PTSD in LMICs under conditions of ongoing adversity.
- Full Text:
- Date Issued: 2020
Improved Stability of Rifampicin in the Presence of Gastric-Resistant Isoniazid Microspheres in Acidic Media
- Mwila, Chiluba, Walker, Roderick B
- Authors: Mwila, Chiluba , Walker, Roderick B
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/183210 , vital:43929 , xlink:href="https://doi.org/10.3390/pharmaceutics12030234"
- Description: The degradation of rifampicin (RIF) in an acidic medium to form 3-formyl rifamycin SV, a poorly absorbed compound, is accelerated in the presence of isoniazid, contributing to the poor bioavailability of rifampicin. This manuscript presents a novel approach in which isoniazid is formulated into gastric-resistant sustained-release microspheres and RIF into microporous floating sustained-release microspheres to reduce the potential for interaction between RIF and isoniazid (INH) in an acidic environment. Hydroxypropyl methylcellulose acetate succinate and Eudragit® L100 polymers were used for the manufacture of isoniazid-loaded gastric-resistant sustained-release microspheres using an o/o solvent emulsification evaporation approach. Microporous floating sustained-release microspheres for the delivery of rifampicin in the stomach were manufactured using emulsification and a diffusion/evaporation process. The design of experiments was used to evaluate the impact of input variables on predefined responses or quality attributes of the microspheres. The percent degradation of rifampicin following 12 h dissolution testing in 0.1 M HCl pH 1.2 in the presence of isoniazid gastric-resistant sustained-release microspheres was only 4.44%. These results indicate that the degradation of rifampicin in the presence of isoniazid in acidic media can be reduced by encapsulation of both active pharmaceutical ingredients to ensure release in different segments of the gastrointestinal tract, potentially improving the bioavailability of rifampicin.
- Full Text:
- Date Issued: 2020
- Authors: Mwila, Chiluba , Walker, Roderick B
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/183210 , vital:43929 , xlink:href="https://doi.org/10.3390/pharmaceutics12030234"
- Description: The degradation of rifampicin (RIF) in an acidic medium to form 3-formyl rifamycin SV, a poorly absorbed compound, is accelerated in the presence of isoniazid, contributing to the poor bioavailability of rifampicin. This manuscript presents a novel approach in which isoniazid is formulated into gastric-resistant sustained-release microspheres and RIF into microporous floating sustained-release microspheres to reduce the potential for interaction between RIF and isoniazid (INH) in an acidic environment. Hydroxypropyl methylcellulose acetate succinate and Eudragit® L100 polymers were used for the manufacture of isoniazid-loaded gastric-resistant sustained-release microspheres using an o/o solvent emulsification evaporation approach. Microporous floating sustained-release microspheres for the delivery of rifampicin in the stomach were manufactured using emulsification and a diffusion/evaporation process. The design of experiments was used to evaluate the impact of input variables on predefined responses or quality attributes of the microspheres. The percent degradation of rifampicin following 12 h dissolution testing in 0.1 M HCl pH 1.2 in the presence of isoniazid gastric-resistant sustained-release microspheres was only 4.44%. These results indicate that the degradation of rifampicin in the presence of isoniazid in acidic media can be reduced by encapsulation of both active pharmaceutical ingredients to ensure release in different segments of the gastrointestinal tract, potentially improving the bioavailability of rifampicin.
- Full Text:
- Date Issued: 2020
In vitro anti-cancer efficacy and phyto-chemical screening of solvent extracts of Kigelia africana (Lam.) Benth
- Mukavi, Justus W, Mayeku, Philip W, Nyaga, Justine M, Kituyi, Sarah N
- Authors: Mukavi, Justus W , Mayeku, Philip W , Nyaga, Justine M , Kituyi, Sarah N
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/429439 , vital:72610 , xlink:href="https://www.cell.com/heliyon/pdf/S2405-8440(20)31325-6.pdf"
- Description: Kigelia africana is a medicinal plant growing naturally in many parts of Africa. In Kenya, a water concoction of the plant is used to treat breast and prostate cancers. Laboratory data on its anti-cancer activity and active principles is limited, hence no scientific rationale for its medicinal use. This study reports on in-vitro toxic activities of dichloromethane and methanol extracts of the plant against human breast cancer cells and phytochemical screening of the two extracts.
- Full Text:
- Date Issued: 2020
- Authors: Mukavi, Justus W , Mayeku, Philip W , Nyaga, Justine M , Kituyi, Sarah N
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/429439 , vital:72610 , xlink:href="https://www.cell.com/heliyon/pdf/S2405-8440(20)31325-6.pdf"
- Description: Kigelia africana is a medicinal plant growing naturally in many parts of Africa. In Kenya, a water concoction of the plant is used to treat breast and prostate cancers. Laboratory data on its anti-cancer activity and active principles is limited, hence no scientific rationale for its medicinal use. This study reports on in-vitro toxic activities of dichloromethane and methanol extracts of the plant against human breast cancer cells and phytochemical screening of the two extracts.
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- Date Issued: 2020