Systematic review of genome-wide association studies of anxiety disorders and neuroticism
- Van Der Walt, Kristien, Campbell, Megan, Stein, Dan J, Dalvie, Shareefa
- Authors: Van Der Walt, Kristien , Campbell, Megan , Stein, Dan J , Dalvie, Shareefa
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/302532 , vital:58205 , xlink:href="https://doi.org//10.1080/15622975.2022.2099970"
- Description: Objectives: To summarise SNP associations identified by genome-wide association studies (GWASs) of anxiety disorders and neuroticism; to appraise the quality of individual studies, and to assess the ancestral diversity of study participants. Methods: We searched PubMed, Scopus, PsychInfo and PubPsych for GWASs of anxiety disorders, non-diagnostic traits (such as anxiety sensitivity), and neuroticism, and extracted all SNPs that surpassed genome-wide significance. We graded study quality using Q-genie scores and reviewed the ancestral diversity of included participants. Results: 32 studies met our inclusion criteria. A total of 563 independent significant variants were identified, of which 29 were replicated nominally in independent samples, and 3 were replicated significantly. The studies had good global quality, but many smaller studies were underpowered. Phenotypic heterogeneity for anxiety (and less so for neuroticism) seemed to reflect the complexity of capturing this trait. Ancestral diversity was poor, with 70% of studies including only populations of European ancestry. Conclusion: The functionality of genes identified by GWASs of anxiety and neuroticism deserves further investigation. Future GWASs should have larger sample sizes, more rigorous phenotyping and include more ancestrally diverse population groups.
- Full Text:
- Date Issued: 2022
- Authors: Van Der Walt, Kristien , Campbell, Megan , Stein, Dan J , Dalvie, Shareefa
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/302532 , vital:58205 , xlink:href="https://doi.org//10.1080/15622975.2022.2099970"
- Description: Objectives: To summarise SNP associations identified by genome-wide association studies (GWASs) of anxiety disorders and neuroticism; to appraise the quality of individual studies, and to assess the ancestral diversity of study participants. Methods: We searched PubMed, Scopus, PsychInfo and PubPsych for GWASs of anxiety disorders, non-diagnostic traits (such as anxiety sensitivity), and neuroticism, and extracted all SNPs that surpassed genome-wide significance. We graded study quality using Q-genie scores and reviewed the ancestral diversity of included participants. Results: 32 studies met our inclusion criteria. A total of 563 independent significant variants were identified, of which 29 were replicated nominally in independent samples, and 3 were replicated significantly. The studies had good global quality, but many smaller studies were underpowered. Phenotypic heterogeneity for anxiety (and less so for neuroticism) seemed to reflect the complexity of capturing this trait. Ancestral diversity was poor, with 70% of studies including only populations of European ancestry. Conclusion: The functionality of genes identified by GWASs of anxiety and neuroticism deserves further investigation. Future GWASs should have larger sample sizes, more rigorous phenotyping and include more ancestrally diverse population groups.
- Full Text:
- Date Issued: 2022
Repetitive symbolic play as a therapeutic process
- Authors: Campbell, Megan
- Date: 2009
- Subjects: Play therapy Symbolic play Child psychology Developmental psychology
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2944 , http://hdl.handle.net/10962/d1002453
- Description: Child centred play therapy theory explains that the facilitative environment of the relationship between child and play therapist allows the child the opportunity to confront emotional pain imbedded in lived, relational experiences, and in so doing process and gain mastery over it. However very little research exists into how the child, through his use of repetitive, symbolic play, as a therapeutic process, achieves this resolution. This research project aims to address this gap in research by exploring and describing repetitive symbolic play as a therapeutic process within child centred play therapy that facilitates change in the child‟s sense of self, assisting him towards healthy adjustment. The research project uses a young boys‟ therapeutic process as a case study, employing a qualitative research design that draws from interpretative research. Fourteen repetitive play sequence themes were analysed within the context of the case formulation and follow-up feedback meetings that took place throughout the therapy process. Using a hermeneutic enquiry the researcher illustrates how the child‟s sense of self, dependent on his perceptions of his external environment, became far more congruent, as evident through his behaviour, when his environment, first in play therapy, then at home and at school became more consistent, supportive and nurturing. Within this facilitative environment the researcher then describes how the child used repetitive symbolic play to address and process emotional issues relating to earlier experiences within his external environment. Hermeneutic analysis suggests that the child‟s use of repetitive symbolic play within the facilitative relationship between him and his therapist became a therapeutic process in and of itself that contributed towards self-directed healing, and change within his sense of self, that promoted healthier adjustment within his environment.
- Full Text:
- Date Issued: 2009
- Authors: Campbell, Megan
- Date: 2009
- Subjects: Play therapy Symbolic play Child psychology Developmental psychology
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2944 , http://hdl.handle.net/10962/d1002453
- Description: Child centred play therapy theory explains that the facilitative environment of the relationship between child and play therapist allows the child the opportunity to confront emotional pain imbedded in lived, relational experiences, and in so doing process and gain mastery over it. However very little research exists into how the child, through his use of repetitive, symbolic play, as a therapeutic process, achieves this resolution. This research project aims to address this gap in research by exploring and describing repetitive symbolic play as a therapeutic process within child centred play therapy that facilitates change in the child‟s sense of self, assisting him towards healthy adjustment. The research project uses a young boys‟ therapeutic process as a case study, employing a qualitative research design that draws from interpretative research. Fourteen repetitive play sequence themes were analysed within the context of the case formulation and follow-up feedback meetings that took place throughout the therapy process. Using a hermeneutic enquiry the researcher illustrates how the child‟s sense of self, dependent on his perceptions of his external environment, became far more congruent, as evident through his behaviour, when his environment, first in play therapy, then at home and at school became more consistent, supportive and nurturing. Within this facilitative environment the researcher then describes how the child used repetitive symbolic play to address and process emotional issues relating to earlier experiences within his external environment. Hermeneutic analysis suggests that the child‟s use of repetitive symbolic play within the facilitative relationship between him and his therapist became a therapeutic process in and of itself that contributed towards self-directed healing, and change within his sense of self, that promoted healthier adjustment within his environment.
- Full Text:
- Date Issued: 2009
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