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Coping mechanisms of unemployed registered counsellors in the South African context

  • Authors: Mogatosi, Ntsako Emmah
  • Date: 2020
  • Subjects: Counselors--Job stress -- South Africa
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: http://hdl.handle.net/10948/46375 , vital:39585
  • Description: ivABSTRACTThe Registered Counsellorcategory has been a developing profession since its inception in 2003. There havebeen few studies done on the coping mechanisms of unemployed Registered Counsellors in the South African context. This field of study is particularly important as Registered Counsellors are the primarymentalhealth care professionals;therefore,their role in psychology is of utmost importance. This study focused on exploring the coping mechanisms of unemployed Registered Counsellors. A qualitative research approach was followed in order to gaina comprehensive understanding regardingthe perceived coping strategies. A combination of purposive,non-probability and snowball sampling techniques was employedto select participants and semi-structured interviews were conducted with them to explore and describe their coping mechanisms. Lazarus and Folkman’stheorywas utilised to provide a theoretical understanding of the coping mechanisms. Unemployment is perceived to cause stress and may lead to maladaptive coping strategies. It was perceived to have an impact on the professional’s goalsand increased financial strain in their lives. However, communication, social and family support, positive attitudes, availability to opportunities and advocacy for the profession were identified as effective coping mechanisms. The majority of the participants perceived good communication about the situation and supportive relationships to be the most effective strategies to be utilised in their lives.
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  • Date Issued: 2020

Corruption elimination within the public infrastructure sector in the Eastern Cape

  • Authors: Mvandaba, Nosicelo
  • Date: 2020
  • Subjects: Business logistics , Government purchasing -- South Africa -- Eastern Cape Management -- Procurement
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: http://hdl.handle.net/10948/46794 , vital:39662
  • Description: The study aimed to reveal the existence of corruption within the public sector and to propose strategies to eliminate it within the supply chain management procurement processes and infrastructure within the public sector in the Province of the Eastern Cape. The study employed a mixed method of quantitative and qualitative data analysis. For the quantitative approach, a series of structured questionnaires were issued to employees within the public sector, many of whom are involved in the procurement process. The officials were asked to rate the views on the importance of the Batho Pele principles in the public sector, risks that may result to the project failure in the public infrastructure sector and the most prevalent causes of corruption For the qualitative method of the study, interviews were conducted for both civil servants and non-public servants who have been involved in procurement processes and coordinating projects. Also, the investigation units were interviewed to determine their views on corruption in the public sector. In addition, the study involved 92 officials within the Eastern Cape Province, and eight interviews were carried out. Initially, 101 public officials were to participate in the study. According to the information that was gathered qualitatively and quantitatively, the most effective methods of eradicating corruption within the procurement department of the public sector are the following: transparency in rules and policies, strengthening of internal audit, management of domestic politics, the emphasis of government focus on preventative rather than curative methods of eliminating corruption, strengthening of consequence management and introduction of anti-corruption committees. Giving monopolistic powers to one person was seen as a gateway to fraud. The research was limited to the views of the officials who are involved in procurement processes in the Province. Not only does the study uncover the possible causes of corruption and its level in the public service but offers constructive recommendations to eliminate it with the hope that economic development will be fostered and the infrastructural climate of the Eastern Cape enhanced.
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  • Date Issued: 2020

Creative production and existential thought: a feminist existential analysis of South African visual artist Berni Searle’s artwork

  • Authors: Mokwena, Palesa
  • Date: 2020
  • Subjects: Women artists -- South Africa , Women artists, Black -- South Africa , Existentialism and art , Feminism and art -- South Africa , Searle, Berni
  • Language: English
  • Type: text , Thesis , Masters , MFA
  • Identifier: http://hdl.handle.net/10962/148005 , vital:38701
  • Description: Through an analysis of the work of South African artist Berni Searle, my study will investigate feminist existential ideas and concepts that have been explored by various creative producers in and outside of Europe/South Africa through different forms of creative productions and under different epistemological categories. ‘Canons’ of European existentialist/feminist thought often exclude the existence of feminist existential knowledge productions and producers outside of Europe. In conducting this study, I am responding to the past and present separatist and identitarian categorisations of creative productions from black/African creative producers, particularly women creative producers in South Africa, creating an alternative canonisation around their selected works. Although canons have been and can be used to drive separatist and identitarian categorisations, it is my hope to elucidate a discourse around the preservations and acknowledgements of South African creative and knowledge productions through a feminist existential framework that canonises important black feminist existentialist works and thereby brings to light their intellectual contributions over and above their identities. My development of a South African feminist existentialism is an attempt to graft a more intersectional, holistic framework to introduce in the feminist and existential discourses, and to proffer a new intersectional holistic paradigm of discussing categories that do not limit creative productions. To frame this research, I will reflect on the politics of historical and contemporary South African society as it is reflected in the works of the chosen creative producers and theorists and to question how we respond as creative feminist existentialists to contemporary South African struggles and how such a lens can be activated as a creative-theoretical tool of investigation.
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  • Date Issued: 2020

Critical success factors for sustainability governance in transport infrastructure delivery in the City of Johannesburg Metropole

  • Authors: Nemutandani, Tshimangadzo Mulisa
  • Date: 2020
  • Subjects: Transportation -- South Africa -- Johannesburg
  • Language: English
  • Type: Thesis , Masters , MSBE
  • Identifier: http://hdl.handle.net/10948/49540 , vital:41734
  • Description: In many engineering sectors, sustainability is a matter of concern. The construction sector is no exception, this is because of its ability to cause harmful effects to the environment through waste generation, energy and water consumption and several other forms of damage to the environment. This has led to experts in the sustainability field calling for a need of sustainable ways of carrying out construction. In this study, information about the sustainability culture and perceptions that exist in Johannesburg was extracted from data gathered from questionnaires based on various types of qualifications, knowledge, and experience of respondents in transport infrastructure delivery. A transportation official understanding the need for sustainable transportation and wishing to do something about it may likely be unable to do so. This is due to the fact that authorities do not always have the mandate, responsibility, power, or support to make decisions that are consistent with sustainable development. It can be said that key issues to sustainability governance of transport infrastructure delivery are: a lack of policy; and a lack of awareness in government, private, and consulting organisations that focus on the delivery of transport infrastructure. The lack of sustainable infrastructure delivery models creates the need to determine the important factors impacting on the governance of sustainable delivery of transport infrastructure in Johannesburg. The matrix has revealed that there is a ‘Moderate’ familiarity and ‘Average’ understanding of sustainability governance as a concept. From the data collected, it is also clear that the current transport infrastructure in Johannesburg is ‘Moderately’ effective at serving its sustainability purpose. This study hopes to be the basis upon which ground-breaking methods to encourage sustainability governance strategies for transport infrastructure projects and further studies are predicated.
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  • Date Issued: 2020

Critical success factors in implementing projects on restituted land parcels in South Africa

  • Authors: Whiting, Christoper Whiting
  • Date: 2020
  • Subjects: Community development -- Management -- South Africa , Community development -- Management -- South Africa -- Case studies , Economic development projects -- Management -- South Africa , Economic development projects -- Management -- South Africa -- Case studies , Land reform -- South Africa -- Economic aspects , Land reform beneficiaries -- South Africa -- Case studies , Restitution -- South Africa -- Case studies
  • Language: English
  • Type: text , Thesis , Masters , MBA
  • Identifier: http://hdl.handle.net/10962/167697 , vital:41504
  • Description: Currently there is a perception in South Africa that projects undertaken on parcels of restituted land are experiencing a much higher failure than success rate. There are, however, a few projects that are reaping the rewards and uplifting their communities, as intended by the land redistribution program. One community in particular, located in Mpumalanga, called community A, is presently undertaking a development project. This development project is one of the most successful restituted land parcel projects ever in South Africa. The purpose of the study is to determine the critical success factors in this community development project that have allowed it to enjoy such high levels of success. Are these critical success factors different from the generic industry critical success factors and, if so, what are they? As informed through literature, the critical success factors focused on in this study are as follows: the influence of management, project communication, knowledge management, the role of senior management, business strategy, project success measurements, and training and development. For the empirical study, a physical questionnaire was handed to 35 management members currently employed in the community development project. The questionnaire requested the demographics of all participants and asked them to rate, using a five-point Likert scale, their perceptions of the present project activities and of the importance of the project activities mentioned in making the project successful. Participants had to indicate the extent to which they agreed with each statement in the questionnaire. The responses obtained from the survey were presented and analysed. The study found that the critical success factor “role of senior management” was the largest problem area in the restituted land development project. “Training and development opportunities” came in second, with both factor areas showing large variances. Recommendations have been given on how to address both these problematic areas in the development project and how future restituted land parcel projects can better utilize these factors to ensure successful project implementation and long-term project success.
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  • Date Issued: 2020

Critical Success Factors to Motivate Citizens to Participate in a Public Safety Smart City Project

  • Authors: Tuswa, Mbali
  • Date: 2020
  • Subjects: Information technology -- Security measures City planning
  • Language: English
  • Type: Thesis , Masters , MCom (Information Systems)
  • Identifier: http://hdl.handle.net/10353/18974 , vital:43004
  • Description: Currently more people reside in urban areas than previously. The population shift from rural to urban results in increased problems with Public Safety. Public Safety initiatives were introduced to address such issues and help reduce the increasing number of urban problems. It is the citizen's responsibility to report the Public Safety issues they observe or experience for authorities to respond quickly in emergency situations, thus maintaining a safer living environment for all citizens. A Public Safety Smart City Project was introduced in the city of East London, South Africa to help improve Public Safety in the city. However, for this to be successful citizens need to contribute by reporting Public Safety issues and suspicious activities. This study is therefore focused on motivational factors to improve citizen participation in a Public Safety Smart City Project. The Design Science Methodology and a mixed method approach guided this research study. Keller’s (2010) Attention, Relevance, Confidence, Satisfaction (ARCS) Theory of Motivation provided the theoretical base for this study. A questionnaire was used to gather data on the motivational factors for participation in a Public Safety Smart City Project. Five Critical Success Factors were developed to motivate citizens to participate in a Public Safety Smart City Project. These Critical Success Factors are: Ensure user satisfaction by providing a toll-free number, Citizens should be able to participate due to their concerns of safety for others, Citizens should be given the opportunity to make a difference in their community, Public Safety initiatives must provide adequate response to citizens and Citizens should be given incentives after participating. The Critical Success Factors were refined and verified through two rounds of expert review. Five factors were identified in the findings as factors that contribute towards motivating citizens participate. These factors include User Satisfaction, Making a difference, Response from Public Safety initiatives, Concern of safety for others and Incentives. The factors were included on the Critical Success Factors
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  • Date Issued: 2020

Crossing shades

  • Authors: Singh, Shareen
  • Date: 2020
  • Subjects: South African fiction (English) -- 21st century
  • Language: English
  • Type: text , Thesis , Masters , MA
  • Identifier: http://hdl.handle.net/10962/145049 , vital:38404
  • Description: This collection of stories draw on culture, history, memory, musings and imagination. The stories are set primarily in South Africa but includes travels to other countries. I explore journeys to different worlds and minds. I challenge the reader to see how place and time influence our ways of seeing, living and evolving. I use different forms and tones that resonate with the subjective nature of each creative piece. My writing includes formal prose as well as works that experiment with fragments, vignettes and flash fiction.
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  • Date Issued: 2020

Cryptocurrencies in the future of money and monetary policy

  • Authors: Brown, Henry Brandon
  • Date: 2020
  • Subjects: Cryptocurrencies
  • Language: English
  • Type: Thesis , Masters , MCom
  • Identifier: http://hdl.handle.net/10948/47495 , vital:40122
  • Description: The idiosyncratic allure of cryptocurrencies, in particular Bitcoin, has attracted widespread, if reticent, attention in the financial markets. Since Bitcoin’s introduction in 2008 there has been a growing interest in digital assets possibly supplanting traditional payment methods. Two conceptual questions raised regarding cryptocurrencies are firstly, whether cryptocurrencies meet the traditional functions of money; secondly, what is the future of cryptocurrencies? This dissertation seeks to examine the future of cryptocurrency by reference to money and monetary policy. The further question, whether cryptocurrencies meet the traditional functions of money, is tested via a combination of theoretical and empirical analysis. The study explores both statistical and empirical models, in illustrative comparative detail, provided by analysis which included ADF and KPSS test models, alongside an ARMA(p,q)-GARCH(1,1) model. Cryptocurrencies present both significant benefits, alongside immense shortcomings. They provide the novel ability to conduct anonymous international transactions on a decentralised platform with lower transaction fees. However, the very nature of that anonymity could provide their downfall as much as they open a market for illicit activities. In addition, cryptocurrency’s significant energy consumption through the mining of cryptocurrencies is of concern to environmentalists. The empirical section of the dissertation consists of a comparative analysis between Bitcoin/USD time series to the Rand/USD time series, with specific attention devoted to the level of volatility of each time series. This was important in determining whether cryptocurrencies fulfil the store of value function of money. The dissertation concluded that Bitcoin/USD time series exhibited identifiable adverse characteristics of autocorrelation and ARCH effects, thus suggesting that Bitcoin/USD is strongly associated with volatility. The Rand/USD signified the same effects although of significantly lesser order than that of Bitcoin/USD. Consequently, cryptocurrencies are seen to act more as an asset than a currency. Nonetheless, cryptocurrencies seem likely to grow as a medium of exchange as more and more businesses gain knowledge of the innovation and seek to adopt innovative ways to become more efficient and follow technology trends. Currently, fiat currencies remain superior in the financial market, simply because cryptocurrencies are perceived not to fulfil the traditional functions of money. However in the future, the market share of cryptocurrencies is likely to increase, and so the future of the financial markets will surely include a coexistence of both fiat and cryptocurrencies, as people’s preferences determine where they feel safe to hold their money.
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  • Date Issued: 2020

Cultural position and the development of posttraumatic stress disorder

  • Authors: Dorfling, Inge-Louise
  • Date: 2020
  • Subjects: Post-traumatic stress disorder
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: http://hdl.handle.net/10948/46371 , vital:39564
  • Description: Trauma exposure and PTSD are widespread health concerns in South Africa. This country is also extremely culturally diverse. The effects of cultural position on PTSD development are unknown. The objective was to explore these possibilities in detail. Individuals eighteen years or older with a stable pre-existing PTSD diagnosis participated in semi-structured voice recorded interviews. Both participants displayed clear conscious changes in cultural position following trauma exposure, some of which are believed to be due to a failure of support and acknowledgement from their collective. This would have contributed to PTSD development. Main themes identified were reactions of others and a paradigm shift. Further, more detailed research is required in this field.
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  • Date Issued: 2020

Customer loyalty programmes in the South African banking sector

  • Authors: Mashau, Mulanga Lawrence
  • Date: 2020
  • Subjects: Banks and banking -- South Africa , Customer loyalty programs -- South Africa
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: http://hdl.handle.net/10948/48883 , vital:41167
  • Description: This treatise explores factors that drive customer participation in banking loyalty programmes in South Africa. The literature review conducted revealed research is required in this area. The lack of research in this field led to the formulation of the problem statement for the study, which focuses on critical factors that drive customer participation in banking loyalty programmes in South Africa. There have been numerous studies conducted on customer loyalty as a concept. There is, however, a lack of studies on customer loyalty in banking loyalty programmes. The literature review explored definitions of customer loyalty, how they pertain to loyalty programmes, with attitudes and behaviours identified as customer loyalty intermediate factors. This study has approached the assessment of customer loyalty in the banking loyalty programmes by exploring the factors that influence or drive customer participation in loyalty programmes in South Africa. The study was conducted using exploratory factor analysis of loyalty programme measurement items that evaluated attitudes and behaviours related to customer loyalty. The factor analysis was undertaken using data gathered from a self-administered online questionnaire. This treatise is part of a bigger study of loyalty programmes and customer loyalty in different sectors. The sample for this study was randomly selected using snowball and convenience sampling. A sample size of n=613 was used in this study. As part of the data analysis, descriptive statistics were used to compress and organise the sample data. Inferential statistics were used to project the findings of the sample data to the full population. The study concluded that flexibility in the context of rewards not expiring was the most important factor that consumers considered when deciding to participate in a banking loyalty programme. This was followed by reward type. The study revealed that banking loyalty programme customers prefer monetary rewards over all reward types for participation in banking loyalty programmes and thus reward type is deemed as a critical factor in customers’ decisions to participate in banking loyalty programmes. The study also found that banking loyalty programme customers do not perceive reward programme communication methods as an important factor influencing their decision to participate in a banking loyalty programme.
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  • Date Issued: 2020

Customer’s perception of e-banking services of South African banks: An analysis of selected South African banks in Gauteng

  • Authors: Kgosieng, Kamogelo
  • Date: 2020
  • Subjects: South Africa -- Banking institutions , Electronic funds transfer
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: http://hdl.handle.net/10948/49862 , vital:41810
  • Description: The South African banking industry has changed from the traditional brick and mortar banks to online banking. The primary objective of the study examines the customers’ perception of the banks’ e-banking services. This study focuses on Gauteng banking customers who bank with the top five banks, namely: FNB, Standard Bank, ABSA, Nedbank and Capitec, and the digital banking platforms offered by the respective banks. A conceptual model based on the SERVQUAL model, including demographic factors and independent variables such as convenience, risk management, customer awareness, reliability and information search, was derived to assist in measuring the relationship of these factors with the overall perception of digitisation in banking. The Statistica package was used to analyse the items and obtain the results of the study. The results revealed that significant relationships exist between all the variables and the perception of e-banking services, with convenience showing up as the highest contributor to customers’ perception of e-banking service channels, followed by reliability. The results of the study indicate that banks should place priority on ensuring the convenient use of their e-banking systems as well ensuring that the systems are reliable and deliver what is expected by the customer.
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  • Date Issued: 2020

Cyclooxygenase-1 as an anti-stroke target: potential inhibitor identification and non-synonymous single nucleotide polymorphism analysis

  • Authors: Muronzi, Tendai
  • Date: 2020
  • Subjects: Cerebrovascular disease , Cerebrovascular disease -- Treatment , Cerebrovascular disease -- Chemotherapy , Cyclooxygenases , High throughput screening (Drug development) , Drug development , Molecular dynamics , South African Natural Compounds Database , ZINC database
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: http://hdl.handle.net/10962/143404 , vital:38243
  • Description: Stroke is the third leading cause of death worldwide, with 87% of cases being ischemic stroke. The two primary therapeutic strategies to reduce post-ischemic brain damage are cellular and vascular approaches. The vascular strategy aims to rapidly re-open obstructed blood vessels, while the cellular approach aims to interfere with the signalling pathways that facilitate neuron damage and death. Unfortunately, popular vascular treatments have adverse side effects, necessitating the need for alternative chemotherapeutics. In this study, cyclooxygenase-1 (COX-1), which plays a significant role in the post- ischemic neuroinflammation and neuronal death, was targeted for identification of novel drug compounds and to assess the effect of nsSNPs on its structure and function. In a drug discovery part, ligands from the South African Natural Compounds Database (SANCDB-https://sancdb.rubi.ru.ac.za/) and ZINC database (http://zinc15.docking.org/) were used for high-throughput virtual screening (HVTS) against COX-1. Additionally, five nsSNPs were being investigated to assess their impact on protein structure and function. Three of these SNPs were in the COX-1 dimer interface. Molecular docking and molecular dynamics simulations revealed asymmetric nature of the protein. Several ligands, peculiar to each monomer, exhibited favourable binding energies in the respective active sites. SNP analysis indicated effects on inter-monomer interactions and protein stability.
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  • Date Issued: 2020

Decent work and informal employment: the case of Bulawayo Metropolitan Province (Central Business District) Zimbabwe

  • Authors: Bob, Shaka Keny
  • Date: 2020
  • Subjects: Labor -- Zimbabwe , Informal sector (Economics) -- Zimbabwe , Job creation -- Zimbabwe , Poor -- Zimbabwe -- Employment , Labor policy -- Zimbabwe , Football coaches -- South Africa
  • Language: English
  • Type: text , Thesis , Masters , MA
  • Identifier: http://hdl.handle.net/10962/115241 , vital:34104
  • Description: Zimbabwe, similar to other developing countries experiences a high level of informal employment. However, most informal jobs are situated in very poor working conditions and are characterised by decent work deficits. Despite the fact that various studies have shown the importance of the informal economy in that it provides livelihood earning opportunities for the majority of people in the Global South, it has remained a largely forgotten sector in policy making in most countries. It is, therefore, important that informal work be taken seriously and efforts must be made to improve working conditions for the urban working poor in the developing world. The purpose of this study is to investigate on the self-reported experiences of informal workers to understand their perspectives surrounding the concept of decent work in the Zimbabwean context. The case study is the Bulawayo metropolitan province, and this study targeted informal workers who trade within the central business district. The study also aimed to measure the decent work deficit scores between two economic sectors (food and clothing traders). This was done by testing the suitability of the Edward Webster Decent Work Deficit Index as a methodology of measuring decent work at a micro level. The analysis is based on a mixed methods study which was carried out through the use of a semi-structured survey. The study revealed that decent work for the sampled informal workers meant work related improvements, insurances and risk management, right of expression and business advancement skills which closely resembles the International Labour Organisation's conceptualisation of decent work. The study also highlighted that childcare assistance and disability insurance are concepts which remained excluded in the current conceptualisation of decent work. The thesis offers a new policy angle which shows that to promote decent work the concept of heterogeneity must be adopted because inequalities persist within the informal economy. The study also suggested that the Edward Webster Decent Work Deficit Index can be used as an appropriate methodology of monitoring the progress towards achieving decent work at the micro level i.e. industry or individual level. This is because since the formation of the decent work concept; the International Labour Organisation has only provided a methodology of how to measure the progress of decent work at the county level. The survey findings revealed that food vendors scored more poorly on the decent work deficit index compared to the clothing traders. The study also identified that food vendors and clothing traders are faced with different challenges which suggests that policy makers must take that into consideration when attempting to design policies or programmes which are aimed at assisting informal workers.
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  • Date Issued: 2020

Default in payment, an application of statistical learning techniques

  • Authors: Gcakasi, Lulama
  • Date: 2020
  • Subjects: Credit -- South Africa -- Risk assessment , Risk management -- Statistical methods -- South Africa , Credit -- Management -- Statistical methods , Commercial statistics
  • Language: English
  • Type: text , Thesis , Masters , MSc
  • Identifier: http://hdl.handle.net/10962/141547 , vital:37984
  • Description: The ability of financial institutions to detect whether a customer will default on their credit card payment is essential for its profitability. To that effect, financial institutions have credit scoring systems in place to be able to estimate the credit risk associated with a customer. Various classification models are used to develop credit scoring systems such as k-nearest neighbours, logistic regression and classification trees. This study aims to assess the performance of different classification models on the prediction of credit card payment default. Credit data is usually of high dimension and as a result dimension reduction techniques, namely principal component analysis and linear discriminant analysis, are used in this study as a means to improve model performance. Two classification models are used, namely neural networks and support vector machines. Model performance is evaluated using accuracy and area under the curve (AUC). The neuarl network classifier performed better than the support vector machine classifier as it produced higher accuracy rates and AUC values. Dimension reduction techniques were not effective in improving model performance but did result in less computationally expensive models.
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  • Date Issued: 2020

Defect Classification in Photovoltaic Modules through Thermal Infrared Imaging using Machine Learning

  • Authors: Dunderdale, Christopher , Clohessy, C M
  • Date: 2020
  • Subjects: Photovoltaic power generation -- South Africa
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: http://hdl.handle.net/10948/48280 , vital:40838
  • Description: As the global energy demand continues to soar, solar energy has become an attractive and environmentally conscious method to meet this demand. This study examines the use of machine learning techniques for defect detection and classification in photovoltaic systems using thermal infrared images. A deep learning and feature-based approach is also investigated for the purpose of detecting and classifying defective photovoltaic modules. The VGG-16 and MobileNet deep learning models are shown to provide good performance for the classification of defects. The scale invariant feature transform (SIFT) descriptor, combined with the random forest and support vector machine classifier, is also used to discriminate between defective and non-defective photovoltaic modules in a South African setting. The successful implementation of this approach has significant potential for cost reduction in defect classification over currently available methods.
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  • Date Issued: 2020

Defining the potential ecological roles of three sea turtle species (Caretta caretta, Chelonia mydas and Eretmochelys imbricata) along the Eastern seaboard of South Africa

  • Authors: Ramboran, Ryan
  • Date: 2020
  • Subjects: Sea turtles -- Conservation -- South Africa , Sea turtles -- Habitat -- Conservation -- South Africa Marine ecology
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: http://hdl.handle.net/10948/49343 , vital:41623
  • Description: Sea turtles were once key species, driving the ecosystem process and energy flows, the past loss of their ecological roles, however has resulted in reduced ecosystem functionality through food web shifts and trophic cascades. Therefore understanding the past and present ecological roles of sea turtles is identified as one of the global research priorities for sea turtle management and conservation.
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  • Date Issued: 2020

Design of a Traffic Surveillance Application using iFogSim

  • Authors: Sinqandu, Mluleki
  • Date: 2020
  • Subjects: Cloud computing
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: http://hdl.handle.net/10353/18676 , vital:42705
  • Description: __iFogSim is a toolkit to model, simulate and evaluate networks of Fog computing, Edge computing and Internet of Things (IoT). This framework provides the capabilities of analysing and evaluating the performance of applications and resource management policies in Fog/IoT environments, based on which designers can model and test their applications. This thesis proposes a novel application model of a traffic surveillance vehicular network application through smart cameras using iFogSim, where the scenario of multiple vehicles tracking is considered. The effectiveness of the proposed application model is assessed and validated by simulations using a modified application model inherited from a case study of intelligent surveillance through distributed camera networks introduced. Simulations are conducted using the iFogSim tool and performance evaluation is done. The comparison between one vehicle and multiple vehicle tracking is done and the results demonstrate that the multiple vehicle application model achieves a better performance in terms of average latency and data transfer rate
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  • Date Issued: 2020

Design, formulation and evalauation of liposomes co-loaded with human serum Albumin and Rifampicin

  • Authors: Bapolisi, Alain Murhimalika
  • Date: 2020
  • Subjects: Liposomes , Serum albumin , Rifampin , Mycobacterium tuberculosis
  • Language: English
  • Type: text , Thesis , Masters , MSc
  • Identifier: http://hdl.handle.net/10962/161780 , vital:40670
  • Description: Tuberculosis (TB) is a devastating infectious disease caused by Mycobacterium tuberculosis and is the leading cause of death from a single infectious agent. The high morbidity and mortality rates of TB are partly due to factors such as the lengthy regimen (of 6–24 months), the development of drug resistance, and the pathogen location within the macrophages. These, with poor physiochemical properties of existing drugs hamper the effectiveness of the treatment despite the existence of potent antibiotics such as Rifampicin (Rif). Hydrophobicity plagues many drugs, including Rif, which are then particularly affected due to inherently poor intracellular availability. Novel drug delivery approaches are therefore needed in order to optimize the cytotoxic potential of said antitubercular drugs. To improve the bioavailability of hydrophobic drugs, numerous delivery strategies have been developed. Amongst these, the coordination of cytotoxic drugs to therapeutic proteins have shown some success for improved efficacy in the management of illnesses including infectious diseases. Of therapeutic proteins, Human Serum Albumin (HSA) is an attractive drug carrier with interestingbenefits such as low immunogenicity, antioxidant properties and improving cellular uptake ofdrugs through HSA-specific binding sites which are expressed on most cells including macrophages, where M. tuberculosis often resides. Hence, combination of Rif to HSA (Rif-HSA)seems a promising approach for improved intracellular delivery of Rif. However, the in vivo stability of colloidal protein-based therapeutics is mostly challenging and an effective vehicle is needed to control the biological fate of such conjugates.Liposomes seem to be appropriate carriers for the Rif-HSA complex due to their reputable applicability for encapsulating diverse materials (i.e., hydrophobic and hydrophilic compounds or small and complex molecules) and preventing chemical and biological degradation of the cargo. Therefore, the main objective of this study was to simultaneously encapsulate Rif and HSA in liposomes, which, to the best of our knowledge, has not been done before. The dual liposomes (Rif-HSA-lip) were made by a modified “Reverse Phase Evaporation” method (REV), following a Design of Experiments (DOE) approach to determine which factors impact the formulation. In addition, liposomes were made from crude soybean lecithin (CSL), rather than expensive and highly purified lipids. The liposomes were fully characterised, and the encapsulation efficiency (î) was monitored using high-performance liquid chromatography (HPLC). The results were correlated with factors such as organic and aqueous phase composition, as well as the in vitro release profile of Rif. Transmission electron microscopy (TEM) results confirmed the formation of spherical dual liposomes nanoparticles of roughly 200 nm. Dynamic light scattering (DLS) and Zeta potential measurements showed a negative charge (<–45 mV) and with satisfactory polydispersity (PDI<0.5). HSA dramatically improved the aqueous solubility of Rif (from1.9 mg/ml in water to around 4.3 mg/ml in HSA 10% solution) mainly due to Rif-HSA hydrophobic interactions. This resulted in a good î of almost 60% for Rif, despite the presence of bulky HSA in the lipid bilayer. These details were confirmed using proton nuclear magnetic resonance (1H NMR) and Fourier-transform infrared spectroscopy (FTIR). Furthermore, energy dispersive X-ray (EDX) and DLS data suggested the presence of HSA poking out on the surface of liposomes, which is encouraging for potential targeted delivery in the future. The in vitro release studies also depicted a substantial improvement in the diffusion of Rif in dual liposomes versus free Rif, from 65% after 12 hours for free Rif to 95% after only 5 hours for Rif- HSA-lip. Finally, stability studies conducted over 30 days at room temperature, showed that the freeze-dried formulations of Rif-HSA-lip exhibited good shelf stability over liposomes with no HSA. This study represents an illustrative example of co-loading of antibiotics and proteins into liposomes, which could encourage further development of novel nanoparticulate tools for the effective management of both drug-susceptible and -resistant infectious diseases such as TB.
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  • Date Issued: 2020

Design, formulation and evaluation of liposomes co-loaded with human serum albumin and rifampicin

  • Authors: Bapolisi, Alain Murhimalika
  • Date: 2020
  • Subjects: Liposomes , Rifampin , Antitubercular agents , Serum albumin , Albumins , Tuberculosis -- Treatment
  • Language: English
  • Type: text , Thesis , Masters , MSc
  • Identifier: http://hdl.handle.net/10962/163179 , vital:41016
  • Description: Tuberculosis (TB) is a devastating infectious disease caused by Mycobacterium tuberculosis and is the leading cause of death from a single infectious agent. The high morbidity and mortality rates of TB are partly due to factors such as the lengthy regimen (of 6–24 months), the development of drug resistance, and the pathogen location within the macrophages. These, with poor physiochemical properties of existing drugs hamper the effectiveness of the treatment despite the existence of potent antibiotics such as Rifampicin (Rif). Hydrophobicity plagues many drugs, including Rif, which are then particularly affected due to inherently poor intracellular availability. Novel drug delivery approaches are therefore needed in order to optimize the cytotoxic potential of said antitubercular drugs. To improve the bioavailability of hydrophobic drugs, numerous delivery strategies have been developed. Amongst these, the coordination of cytotoxic drugs to therapeutic proteins have shown some success for improved efficacy in the management of illnesses including infectious diseases. Of therapeutic proteins, Human Serum Albumin (HSA) is an attractive drug carrier with interesting benefits such as low immunogenicity, antioxidant properties and improving cellular uptake of drugs through HSA-specific binding sites which are expressed on most cells including macrophages, where M. tuberculosis often resides. Hence, combination of Rif to HSA (Rif-HSA) seems a promising approach for improved intracellular delivery of Rif. However, the in vivo stability of colloidal protein-based therapeutics is mostly challenging and an effective vehicle is needed to control the biological fate of such conjugates. Liposomes seem to be appropriate carriers for the Rif-HSA complex due to their reputable applicability for encapsulating diverse materials (i.e., hydrophobic and hydrophilic compounds or small and complex molecules) and preventing chemical and biological degradation of the cargo. Therefore, the main objective of this study was to simultaneously encapsulate Rif and HSA in liposomes, which, to the best of our knowledge, has not been done before. The dual liposomes (Rif-HSA-lip) were made by a modified “Reverse Phase Evaporation” method (REV), following a Design of Experiments (DOE) approach to determine which factors impact the formulation. In addition, liposomes were made from crude soybean lecithin (CSL), rather than expensive and highly purified lipids. iv The liposomes were fully characterised, and the encapsulation efficiency (î) was monitored using high-performance liquid chromatography (HPLC). The results were correlated with factors such as organic and aqueous phase composition, as well as the in vitro release profile of Rif. Transmission electron microscopy (TEM) results confirmed the formation of spherical dual liposomes nanoparticles of roughly 200 nm. Dynamic light scattering (DLS) and Zeta potential measurements showed a negative charge (<–45 mV) and with satisfactory polydispersity (PDI<0.5). HSA dramatically improved the aqueous solubility of Rif (from1.9 mg/ml in water to around 4.3 mg/ml in HSA 10% solution) mainly due to Rif-HSA hydrophobic interactions. This resulted in a good î of almost 60% for Rif, despite the presence of bulky HSA in the lipid bilayer. These details were confirmed using proton nuclear magnetic resonance (1H NMR) and Fourier-transform infrared spectroscopy (FTIR). Furthermore, energy dispersive X-ray (EDX) and DLS data suggested the presence of HSA poking out on the surface of liposomes, which is encouraging for potential targeted delivery in the future. The in vitro release studies also depicted a substantial improvement in the diffusion of Rif in dual liposomes versus free Rif, from 65% after 12 hours for free Rif to 95% after only 5 hours for Rif- HSA-lip. Finally, stability studies conducted over 30 days at room temperature, showed that the freeze-dried formulations of Rif-HSA-lip exhibited good shelf stability over liposomes with no HSA. This study represents an illustrative example of co-loading of antibiotics and proteins into liposomes, which could encourage further development of novel nanoparticulate tools for the effective management of both drug-susceptible and -resistant infectious diseases such as TB.
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  • Date Issued: 2020

Detecting the transnational space: metaphysical detecting in Kazuo Ishiguro’s When we were orphans, Michiel Heyns’s Lost ground, and Amitav Gosh’s The Calcutta chromosome

  • Authors: Botes, Niki
  • Date: 2020
  • Subjects: Literature and transnationalism , Detective and mystery stories -- History and criticism , Ishiguro, Kazuo, 1954- , Ishiguro, Kazuo, 1954- -- When we were orpahns , Heyns, Michiel , Heyns, Michiel -- Lost ground , Ghosh, Amitav, 1956- , Ghosh, Amitav, 1956- -- The Calcutta chromosome
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: http://hdl.handle.net/10962/140971 , vital:37933
  • Description: The transnational detectives in the three primary texts under scrutiny—Kazuo Ishiguro’s When We Were Orphans, Michiel Heyns’s Lost Ground, and Amitav Ghosh’s The Calcutta Chromosome—are regarded as metaphysical detectives in this thesis. As transnational figures, they criss-cross physical and national borders, but their investigations also often require the crossing of epistemological and ontological borders, as well as thinking outside of binaries. The fictional transnational, postcolonial worlds presented in these texts all feature a lack of change and the persistence of the socio-economic inequalities and discriminations of the colonial or, in the case of Lost Ground, the apartheid past. This thesis will argue that the three texts foreground the inability to break free from conceptual frameworks and a lack in human relationships as two possible reasons why the communities and societies in question have not been able to affect change. To solve the various mysteries in the texts, the transnational detectives need to find new ways of knowing and being. The lessons that these detectives learn and the personal changes they experience serve as synecdoche for how a better tomorrow for the transnational, postcolonial world could possibly be achieved. The methodology employed in this thesis involves a comparative reading of the three primary texts. To analyse and interpret these texts, this thesis draws on the philosophies of postmodern philosophers such as Martin Heidegger, Michel Foucault, Jacques Derrida, and Emmanuel Levinas, as well as postcolonial theorists like Edward Said, Gayatri Chakravorty Spivak, and Homi K. Bhabha. The thesis will contend that especially Derrida’s work on deconstruction, which forms the conceptual basis for Bhabha’s notion of the ‘third space,’ as well as Levinas’s anti-totalitarian approach with regard to the ethical relationship between the self and the other, are viable better ways of knowing and being in the transnational, postcolonial worlds presented in the texts. Derrida’s notion of différance and the trace, as well as Bhabha’s third space, this thesis contends, completely destabilises binary thinking and offers ways to think outside of the limited frameworks of ideological discourse. This thesis also posits that Levinas’s metaphysical and pluralistic interpretation of how the self should, and can, relate to the other, presents a better way of forming human relationships and has the potential to affect positive change.
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  • Date Issued: 2020
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