English additional language student teachers’ development of oral strategic competence and confidence
- Authors: Meyers, Rozanne Elanore
- Date: 2022-04-08
- Subjects: Student teaching South Africa , Communicative competence South Africa , Oral communication , Native language and education , Language arts , Verbal ability , Multilingual education
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/263613 , vital:53643
- Description: This case study sought to understand how oral strategic and discourse competence and confidence developed in student teachers using English, their additional language, firstly as a tool of learning and secondly, as a medium of instruction in education environments. Within the broad qualitative approach an interpretive framework was adopted using multiple data collection tools. This was in order to privilege detailed accounts of participants’ experiences. Namely, unstructured interviews, drawings, observational checklists, and selfassessment questionnaires. Participants’ oral strategic and discourse competence were assessed using an observation checklist as they presented micro-teaching lessons. Additionally, participants completed a self-assessment questionnaire, reflecting on their oral competence after conducting their micro-teaching lessons. These perceptions were confirmed through a discussion of drawings that illustrated how they perceived themselves during lectures when they had to use English during oral interaction with lecturers and fellow students. Finally, unstructured interviews were conducted after participants completed their micro-teaching lessons and after participants had completed their drawings. The raw data from the four tools were analysed using a thematic approach. Main themes and categories were analysed and discussed to provide answers to the research questions. Data correlated the attitude of participants towards English and their level of oral confidence and competence. The main findings were that students were motivated to develop their oral English competence because they believed it was an important skill for teachers to possess. This motivation also proved to be a leading factor in participants’ competence despite the negative emotions they identified during spoken exchanges. Furthermore, the analysis found that collaborating with fellow students in making meaning of oral communication during lectures, increased students’ oral competence and their confidence because they were communicating in smaller groups. However, in certain situations, collaborating with students also decreased their confidence. Findings indicated that reciprocal facial expressions and the body language of those who engaged orally with the student teachers, increased their oral confidence as it served as an indication to them that they were understood. Based on these findings, recommendations are made regarding interactions during lectures for teacher training programmes in Higher Education in South Africa, for lecturers and lecturing practices, and curriculum designers in the South African Department of Education. , Thesis (MEd) -- Faculty of Education, Education, 2022
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- Date Issued: 2022-04-08
Synthesis and evaluation of the medicinal potential of novel 4-hydroxycoumarin derivatives
- Authors: Manyeruke, Meloddy Hlatini
- Date: 2022-04-08
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/164458 , vital:41120 , doi:10.21504/10962/164458
- Description: This research has focused on the synthesis and biological evaluation of a broad range of compounds characterised by the presence of the pharmacologically significant 4-hydroxycoumalin scaffold. The compounds were designed to contain additional pharmachophoric centres to enhance bioactivity and generate lead compounds with dualaction potential. The use of 4-hydroxycoumarin as the primary synthon enabled access to various series of 4-hydroxycoumarin conjugates, the reactive 3-position on the 4-hydroxycoumarin moiety being exploited for regioselective construction of the targeted compounds in several steps. Some of the reactants required in the construction of these compounds were specially synthesised and included propargyloxy benzaldehydes, benzyloxy benzaldehydes and 2,3-dihydroxysuccino-dihydride. Overall, eight different families of novel compounds were accessed, comprising conjugates of 4-hydroxycoumarin with bisethylidenesuccinohyrazide, trifluoroacetamide, amino, benzyloxyphenyl-iminoethyl, benzylidenehyrazinyl-thiazoyl, benzylidenehydrazonoethyl, propargyloxybenzylidenehydrazonoethyl and phenylacryloyl moieties using protocols that required minimal work-up and purification. The eighty novel compounds synthesised in the study were fully characterised using HMRS and advanced NMR techniques. Cytotoxicity, HIV-1 IN and PR inhibitory, and antitrypanosomal, antimalarial and anti-Mtb assays were conducted on the synthesised coumarin derivatives. Several compounds exhibited activity against HIV-1 IN, the most potent being a bis-ethylidenesuccinohyrazide with an IC50 value of 3.5 μM. Various compounds exhibited anti-malarial activity (% pLDH viability in the range 62-77%), anti-trypanosomal activity (the most potent with an IC50 = 0.9 μM against T.b. brucei) and a measure of anti-Mtb activity. Apart from two chalconyl derivatives, none of the synthesised compounds exhibited significant cytotoxicity. Conflicting results were obtained from the in silico docking studies; in some cases supporting the observed in vitro assay data while, in others, exhibiting no correlation. , Thesis (PhD) -- Faculty of Science, Chemistry, 2020
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- Date Issued: 2022-04-08