Copper dithiocarbamate complexes and copper sulfide nanoparticles : Synthesis, characterization and antifungal studies
- Botha, Nandipha Loveness https://orcid.org/0000-0001-8353-3512
- Authors: Botha, Nandipha Loveness https://orcid.org/0000-0001-8353-3512
- Date: 2015-01
- Subjects: Copper sulfide , Complex compounds , Nanoparticles
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/24283 , vital:62598
- Description: Six dithiocarbamate ligands were synthesized from anisidine, aniline, ethyl aniline, butyl amine, morpholine and piperidine and used to synthesize homoleptic copper(II) dithiocarbamate complexes. The ligands and their corresponding complexes were characterized by conductivity measurement, FTIR and UV-Vis spectroscopy. The ligands were further characterized using NMR spectroscopy. The electronic spectra of the complexes showed that the coordination geometries around the Cu2+ ion is four coordinate square planar. FTIR spectroscopic studies indicated that the dithiocarbamate ligands are bidentately coordinated to the copper ion through the sulfur atoms with the C-S stretching frequencies changing from two peaks in the ligands to single sharp peaks in the corresponding metal complexes. The complexes were used as single source precursors to synthesize copper sulfide nanoparticles. All the six complexes were thermolysed at 180 oC to prepare copper sulfide nanoparticles and three of them were further thermolysed at 120 oC to study the effects of temperature on size and shape of the nanoparticles. All the nanoparticles were characterized with UV-Vis, PL, XRD, TEM, SEM and EDX. The optical properties of the as-prepared CuS nanoparticles showed that they are quantum confined with absorption band edges that are blue shifted compared to bulk CuS and all the as-prepared CuS nanoparticles showed narrow emission curves. The XRD diffraction patterns were indexed to the hexagonal covellite CuS crystalline phase with estimated particle sizes of 15.8-23.24 nm. These sizes are significantly different from the values, 3.02-98.94 nm obtained from TEM studies. The TEM images also showed nanoparticles with varied shapes with some agglomerations. SEM micrographs showed that the morphologies of the nanoparticles are mostly smooth surfaces and EDX spectra analyses confirmed the formation of the nanoparticles. Thermolysis of three of the complexes at 120 oC confirmed that temperature do affect the optical and structural properties of the CuS nanoparticles. Only three complexes soluble in DMSO were screened for their antimicrobial activity. Three complexes C1, C4 and C5 were screened against four fungi organisms, namely: Candida rugosa, Candida neoformans, Candida albicans and Trychophyton mucoides. All the compounds were promising as shown by the minimum inhibitory concentrations determined. C5 was the most active compound against all the organisms. They were also screened against four bacteria organisms and they were all active but not as they were against fungi organisms. , Thesis (MSc) -- Faculty of Science and Agriculture, 2015
- Full Text:
- Authors: Botha, Nandipha Loveness https://orcid.org/0000-0001-8353-3512
- Date: 2015-01
- Subjects: Copper sulfide , Complex compounds , Nanoparticles
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/24283 , vital:62598
- Description: Six dithiocarbamate ligands were synthesized from anisidine, aniline, ethyl aniline, butyl amine, morpholine and piperidine and used to synthesize homoleptic copper(II) dithiocarbamate complexes. The ligands and their corresponding complexes were characterized by conductivity measurement, FTIR and UV-Vis spectroscopy. The ligands were further characterized using NMR spectroscopy. The electronic spectra of the complexes showed that the coordination geometries around the Cu2+ ion is four coordinate square planar. FTIR spectroscopic studies indicated that the dithiocarbamate ligands are bidentately coordinated to the copper ion through the sulfur atoms with the C-S stretching frequencies changing from two peaks in the ligands to single sharp peaks in the corresponding metal complexes. The complexes were used as single source precursors to synthesize copper sulfide nanoparticles. All the six complexes were thermolysed at 180 oC to prepare copper sulfide nanoparticles and three of them were further thermolysed at 120 oC to study the effects of temperature on size and shape of the nanoparticles. All the nanoparticles were characterized with UV-Vis, PL, XRD, TEM, SEM and EDX. The optical properties of the as-prepared CuS nanoparticles showed that they are quantum confined with absorption band edges that are blue shifted compared to bulk CuS and all the as-prepared CuS nanoparticles showed narrow emission curves. The XRD diffraction patterns were indexed to the hexagonal covellite CuS crystalline phase with estimated particle sizes of 15.8-23.24 nm. These sizes are significantly different from the values, 3.02-98.94 nm obtained from TEM studies. The TEM images also showed nanoparticles with varied shapes with some agglomerations. SEM micrographs showed that the morphologies of the nanoparticles are mostly smooth surfaces and EDX spectra analyses confirmed the formation of the nanoparticles. Thermolysis of three of the complexes at 120 oC confirmed that temperature do affect the optical and structural properties of the CuS nanoparticles. Only three complexes soluble in DMSO were screened for their antimicrobial activity. Three complexes C1, C4 and C5 were screened against four fungi organisms, namely: Candida rugosa, Candida neoformans, Candida albicans and Trychophyton mucoides. All the compounds were promising as shown by the minimum inhibitory concentrations determined. C5 was the most active compound against all the organisms. They were also screened against four bacteria organisms and they were all active but not as they were against fungi organisms. , Thesis (MSc) -- Faculty of Science and Agriculture, 2015
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Synthesis, characterization and antibacterial studies of metal complexes of substituted thiourea
- Authors: Zulu, Happy Nonkululeko
- Date: 2012-03
- Subjects: Complex compounds , Halides , Ligands
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/24327 , vital:62636
- Description: Eighteen complexes Co(II), Cu(II), Zn(II), and Fe(III) with phenylthiourea, diethylthiourea, disopropylthiourea and dimethylthiourea were synthesized and characterized by elemental analysis, UV-Vis, FTIR, conductivity measurements. The complexes were formulated as either four coordinate for the metal(II) or six coordinate for Fe(III). The proposed formulations are consistent with the spectroscopic data for the complexes. The single crystal X-ray structure of the Zn(II) complex of phenylthiourea, Co(II) complex of diethylthiourea and Zn(II) complex of diisopropylthiourea are also reported. The X-ray crystal structures for these complexes revealed distorted tetrahedral geometry around the metal ions showed that the metal ions are coordinated to two molecules of the substituted thiourea through the sulphur atom and two either acetates or chlorides ions complete the four-coordinate geometry. The in vitro antibacterial activity of the complexes was studied against six bacterial strains using disc diffusion and broth micro-dilution methods. The complexes showed selective antibacterial activity. , Thesis (MSc) -- Faculty of Science and Agriculture, 2012
- Full Text:
- Authors: Zulu, Happy Nonkululeko
- Date: 2012-03
- Subjects: Complex compounds , Halides , Ligands
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/24327 , vital:62636
- Description: Eighteen complexes Co(II), Cu(II), Zn(II), and Fe(III) with phenylthiourea, diethylthiourea, disopropylthiourea and dimethylthiourea were synthesized and characterized by elemental analysis, UV-Vis, FTIR, conductivity measurements. The complexes were formulated as either four coordinate for the metal(II) or six coordinate for Fe(III). The proposed formulations are consistent with the spectroscopic data for the complexes. The single crystal X-ray structure of the Zn(II) complex of phenylthiourea, Co(II) complex of diethylthiourea and Zn(II) complex of diisopropylthiourea are also reported. The X-ray crystal structures for these complexes revealed distorted tetrahedral geometry around the metal ions showed that the metal ions are coordinated to two molecules of the substituted thiourea through the sulphur atom and two either acetates or chlorides ions complete the four-coordinate geometry. The in vitro antibacterial activity of the complexes was studied against six bacterial strains using disc diffusion and broth micro-dilution methods. The complexes showed selective antibacterial activity. , Thesis (MSc) -- Faculty of Science and Agriculture, 2012
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