Constraining the role of carbonate assimilation on spinel stability in oxide ores of the Flatreef, Bushveld Complex, South Africa
- Authors: Dyan, Siyasanga
- Date: 2021-04
- Subjects: Oxide minerals -- South Africa -- Bushveld Complex , Transvaal Supergroup (South Africa) , Magmas -- South Africa -- Bushveld Complex , Petrogenesis -- South Africa -- Bushveld Complex , Spinel group – South Africa -- South Africa -- Bushveld Complex , Dolomite -- South Africa -- Bushveld Complex
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/174578 , vital:42490
- Description: The northern limb of the Bushveld Complex shows significant evidence for footwall rock- magma interaction, as a result of the emplacement of magmas onto the Transvaal Supergroup sediments. The Platreef of the northern limb is known to have involved extensive contamination of the magma. The lateral extension of the Platreef, the Flatreef, is less contaminated and comprises PGE-mineralization and thick chromitite layers. This enables successful stratigraphic correlation to the Upper Critical Zone of the eastern and western limbs of the Bushveld Complex. This study aims at addressing the influence of dolomitic floor rock contamination on the formation of spinels of the Flatreef and how they may differ to their occurrences in the Bushveld Complex elsewhere. Three main drill cores (UMT-345, UMT-335, and UMT-094) from the deep drilling program by Ivanhoe Mine, north of Turfspruit, were logged and sampled. The drill cores contained rocks contaminated by dolomite in varying degrees, depending on the proportion of carbonate xenoliths present. A total of sixty-two samples were obtained from the UG-2- equivalent chromitite seam, down into the hybrid contaminated units (Footwall Assimilation Zone; FAZ). Petrographic examination of the drill cores revealed that the feldspathic pyroxenite and chromitite layers are the most pristine lithologies in the Flatreef. The chromitite layers occur as a semi-massive to massive ores. The FAZ rocks are mainly dominated by the abundance of Al-rich Cr-spinels (Mg#30-80), clinopyroxenes with a high Ca-Tschermak component (up to 35 mol.%), olivines (Fo72-84), and plagioclase (An31-78). Geochemical characteristics of the feldspathic pyroxenite and chromitite seams include low CaO/Al2O3 and Ca/SiO2 ratios, the low abundance of REE and HFSE. In contrast, the FAZ samples display high CaO/Al2O3 and CaO/SiO2 ratios, suggesting mobilization of CaO-rich fluids derived from the associated dolomite xenoliths. Observations from lithostratigraphic element profiles indicate spikes in CaO within FAZ units relative to the feldspathic pyroxene, indicating a secondary source of CaO linked to proximity to carbonate xenoliths intersected in the core. The assimilation-fractional crystallization model performed with the Upper Critical Zone parental melt and dolomite produced assemblages dominated by spinel, olivine, clinopyroxene, and plagioclase, relating to those of the most contaminated rocks of footwall assimilation zones. The model also showed that large quantities of CO2 were produced during assimilation. High amounts of CO2-fluids mobilized in the melt would have interacted with the melt and increased the overall oxidation conditions. Oxygen fugacity (ƒO2) values were constrained from the spinels in the FAZ and chromites in chromitite seams. Spinels within the most contaminated rocks of the FAZ recorded relatively high ƒO2 values ranging between NNO-0.2 and NNO+1.8 (relative to the Nickel-Nickel-Oxide buffer. High ƒO2 values in spinels from the FAZ suggest that the melt interacted with greater amounts of oxidative CO2-fluids during decarbonation reactions. Such high redox conditions could have triggered the saturation and crystallization of spinels. Comparison of mineral compositions and ƒO2 of UG-2 chromites from the Flatreef with UG-2 from the eastern limb, western limb, chromitites from the Platreef and Uitkomst Complex reveal that Flatreef chromites are of most similar to those of the Platreef Uitkosmt Complex. The northern limb and Uitkomst Complex chromites have high ƒO2 values (NNO+0.3 to NNO+1.2), indicating their apparent link to the Malmani dolomite. Interaction of magma with the Malmani dolomite would have produced high quantities of CO2, triggering an increase in oxidizing conditions. Such an effect is most prominent in the Flatreef chromitites that are in contact with the FAZ. The chromites are characterised by high ƒO2 (NNO+1.2) and distinct compositions (low Cr2O3, high Fe3+/Fetotal, and TiO2). Thus, it is proposed that carbonate assimilation in the Flatreef triggered the precipitation of these distinctive chromites proximal to FAZ, due to liberation of substantial amounts of CO2-rich fluids with a highly oxidative capacity. Carbonate assimilation in layered intrusions can be used as a monitor potential precipitation of chromites. , Thesis (MSc)--Rhodes University, Faculty of Science, Department of Geology, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Dyan, Siyasanga
- Date: 2021-04
- Subjects: Oxide minerals -- South Africa -- Bushveld Complex , Transvaal Supergroup (South Africa) , Magmas -- South Africa -- Bushveld Complex , Petrogenesis -- South Africa -- Bushveld Complex , Spinel group – South Africa -- South Africa -- Bushveld Complex , Dolomite -- South Africa -- Bushveld Complex
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/174578 , vital:42490
- Description: The northern limb of the Bushveld Complex shows significant evidence for footwall rock- magma interaction, as a result of the emplacement of magmas onto the Transvaal Supergroup sediments. The Platreef of the northern limb is known to have involved extensive contamination of the magma. The lateral extension of the Platreef, the Flatreef, is less contaminated and comprises PGE-mineralization and thick chromitite layers. This enables successful stratigraphic correlation to the Upper Critical Zone of the eastern and western limbs of the Bushveld Complex. This study aims at addressing the influence of dolomitic floor rock contamination on the formation of spinels of the Flatreef and how they may differ to their occurrences in the Bushveld Complex elsewhere. Three main drill cores (UMT-345, UMT-335, and UMT-094) from the deep drilling program by Ivanhoe Mine, north of Turfspruit, were logged and sampled. The drill cores contained rocks contaminated by dolomite in varying degrees, depending on the proportion of carbonate xenoliths present. A total of sixty-two samples were obtained from the UG-2- equivalent chromitite seam, down into the hybrid contaminated units (Footwall Assimilation Zone; FAZ). Petrographic examination of the drill cores revealed that the feldspathic pyroxenite and chromitite layers are the most pristine lithologies in the Flatreef. The chromitite layers occur as a semi-massive to massive ores. The FAZ rocks are mainly dominated by the abundance of Al-rich Cr-spinels (Mg#30-80), clinopyroxenes with a high Ca-Tschermak component (up to 35 mol.%), olivines (Fo72-84), and plagioclase (An31-78). Geochemical characteristics of the feldspathic pyroxenite and chromitite seams include low CaO/Al2O3 and Ca/SiO2 ratios, the low abundance of REE and HFSE. In contrast, the FAZ samples display high CaO/Al2O3 and CaO/SiO2 ratios, suggesting mobilization of CaO-rich fluids derived from the associated dolomite xenoliths. Observations from lithostratigraphic element profiles indicate spikes in CaO within FAZ units relative to the feldspathic pyroxene, indicating a secondary source of CaO linked to proximity to carbonate xenoliths intersected in the core. The assimilation-fractional crystallization model performed with the Upper Critical Zone parental melt and dolomite produced assemblages dominated by spinel, olivine, clinopyroxene, and plagioclase, relating to those of the most contaminated rocks of footwall assimilation zones. The model also showed that large quantities of CO2 were produced during assimilation. High amounts of CO2-fluids mobilized in the melt would have interacted with the melt and increased the overall oxidation conditions. Oxygen fugacity (ƒO2) values were constrained from the spinels in the FAZ and chromites in chromitite seams. Spinels within the most contaminated rocks of the FAZ recorded relatively high ƒO2 values ranging between NNO-0.2 and NNO+1.8 (relative to the Nickel-Nickel-Oxide buffer. High ƒO2 values in spinels from the FAZ suggest that the melt interacted with greater amounts of oxidative CO2-fluids during decarbonation reactions. Such high redox conditions could have triggered the saturation and crystallization of spinels. Comparison of mineral compositions and ƒO2 of UG-2 chromites from the Flatreef with UG-2 from the eastern limb, western limb, chromitites from the Platreef and Uitkomst Complex reveal that Flatreef chromites are of most similar to those of the Platreef Uitkosmt Complex. The northern limb and Uitkomst Complex chromites have high ƒO2 values (NNO+0.3 to NNO+1.2), indicating their apparent link to the Malmani dolomite. Interaction of magma with the Malmani dolomite would have produced high quantities of CO2, triggering an increase in oxidizing conditions. Such an effect is most prominent in the Flatreef chromitites that are in contact with the FAZ. The chromites are characterised by high ƒO2 (NNO+1.2) and distinct compositions (low Cr2O3, high Fe3+/Fetotal, and TiO2). Thus, it is proposed that carbonate assimilation in the Flatreef triggered the precipitation of these distinctive chromites proximal to FAZ, due to liberation of substantial amounts of CO2-rich fluids with a highly oxidative capacity. Carbonate assimilation in layered intrusions can be used as a monitor potential precipitation of chromites. , Thesis (MSc)--Rhodes University, Faculty of Science, Department of Geology, 2021
- Full Text:
- Date Issued: 2021-04
Creating shared value through innovating business models: a case study of the Mapela Water Project
- Authors: Moyo, Bonnie
- Date: 2021-04
- Subjects: Business planning -- South Africa , Strategic planning -- South Africa , Sustainable development -- South Africa , Social responsibility of business -- South Africa , Mineral industries -- South Africa , Mapela Water Project , Hourglass Model
- Language: English
- Type: thesis , text , Masters , MBA
- Identifier: http://hdl.handle.net/10962/177135 , vital:42793
- Description: Shared value creation is a contemporary concept that aims to address the strained relationship between business and society through business models that expand the competitive advantage of business while addressing societal challenges in the business environment. Being a novel concept, studies on how value is created and shared are limited, especially where the unit of analysis is a specific project. This paper investigates how value is created and shared among stakeholders using a water project case study reported as a shared value initiative. The investigation is considered under the Hourglass Model (Ludeke-Freund, Massa, Bocken, Brent and Musango, 2016) as a guiding framework. This sustainable business model is suggested as a business model that creates shared value. The study uses a qualitative research approach to investigate the inputs into the Hourglass Model (Ludeke-Freund et al., 2016) in the form of capitals, briefly considers the business models of specific stakeholders and then analyses the value created, missed and destroyed for each stakeholder through their value creation mechanisms. In the findings, six different capitals are identified from the participating stakeholders, and the value created, destroyed, and missed is discussed in the context of shared value principles. The findings show that capitals are used as inputs into the Hourglass Model and are consumed, created, and regenerated. There is also the realisation from the findings that different stakeholders required different and varying amounts of the six capitals identified. The interconnectedness of the capitals is shown in the study, and the findings show that the context of the environment within which a project operates contributes to the creation of shared value. As with the six capitals, the findings show that multiple stakeholders create shared value confirming stakeholder theory's guiding principles regarding stakeholder salience, which are relevant for creating shared value. Some stakeholders are identified as being more important to creating shared value in the project than others. Trade-offs are then required for value creation from a finite pool of capitals and stakeholders to consider the capitals and stakeholders' long and short-term impacts. Identifying stakeholders and the capitals allowed the researcher to consider the value created, destroyed and missed in the project. This assessment of shared value generated forms part of the findings on business models' outcomes for shared value, summarised for the project. Based on these areas where the outcomes are missing or destroying value, recommendations are made to address these opportunities, and an area of further research is identified. Drawing on these outcomes, developing clusters as per the value creation avenues of shared value would be the most appropriate avenue for this project. The study adds to the shared value body of knowledge by operationalising the Hourglass Model (Ludeke-Freund et al., 2016) and illustrating how the Model can be used to consider shared value creation. , Thesis (MBA) -- Faculty of Commerce, Rhodes Business School, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Moyo, Bonnie
- Date: 2021-04
- Subjects: Business planning -- South Africa , Strategic planning -- South Africa , Sustainable development -- South Africa , Social responsibility of business -- South Africa , Mineral industries -- South Africa , Mapela Water Project , Hourglass Model
- Language: English
- Type: thesis , text , Masters , MBA
- Identifier: http://hdl.handle.net/10962/177135 , vital:42793
- Description: Shared value creation is a contemporary concept that aims to address the strained relationship between business and society through business models that expand the competitive advantage of business while addressing societal challenges in the business environment. Being a novel concept, studies on how value is created and shared are limited, especially where the unit of analysis is a specific project. This paper investigates how value is created and shared among stakeholders using a water project case study reported as a shared value initiative. The investigation is considered under the Hourglass Model (Ludeke-Freund, Massa, Bocken, Brent and Musango, 2016) as a guiding framework. This sustainable business model is suggested as a business model that creates shared value. The study uses a qualitative research approach to investigate the inputs into the Hourglass Model (Ludeke-Freund et al., 2016) in the form of capitals, briefly considers the business models of specific stakeholders and then analyses the value created, missed and destroyed for each stakeholder through their value creation mechanisms. In the findings, six different capitals are identified from the participating stakeholders, and the value created, destroyed, and missed is discussed in the context of shared value principles. The findings show that capitals are used as inputs into the Hourglass Model and are consumed, created, and regenerated. There is also the realisation from the findings that different stakeholders required different and varying amounts of the six capitals identified. The interconnectedness of the capitals is shown in the study, and the findings show that the context of the environment within which a project operates contributes to the creation of shared value. As with the six capitals, the findings show that multiple stakeholders create shared value confirming stakeholder theory's guiding principles regarding stakeholder salience, which are relevant for creating shared value. Some stakeholders are identified as being more important to creating shared value in the project than others. Trade-offs are then required for value creation from a finite pool of capitals and stakeholders to consider the capitals and stakeholders' long and short-term impacts. Identifying stakeholders and the capitals allowed the researcher to consider the value created, destroyed and missed in the project. This assessment of shared value generated forms part of the findings on business models' outcomes for shared value, summarised for the project. Based on these areas where the outcomes are missing or destroying value, recommendations are made to address these opportunities, and an area of further research is identified. Drawing on these outcomes, developing clusters as per the value creation avenues of shared value would be the most appropriate avenue for this project. The study adds to the shared value body of knowledge by operationalising the Hourglass Model (Ludeke-Freund et al., 2016) and illustrating how the Model can be used to consider shared value creation. , Thesis (MBA) -- Faculty of Commerce, Rhodes Business School, 2021
- Full Text:
- Date Issued: 2021-04
Customer perceptions on Customer Relationship Management (CRM) and its possible influence on Revenue Management (RM) at a selected water board in South Africa
- Authors: Manyonganise, Joshua Anesu
- Date: 2021-04
- Subjects: Customer relations -- Management , Revenue management -- South Africa -- Eastern Cape , Municipal government -- South Africa -- Eastern Cape , Municipal services -- South Africa -- Eastern Cape , Water-supply -- South Africa -- Eastern Cape , Amatola Water (Utility) , South Africa. National Water Act, 1998
- Language: English
- Type: thesis , text , Masters , MCom
- Identifier: http://hdl.handle.net/10962/177214 , vital:42800
- Description: The primary activity of water boards is to provide water services (bulk portable, and bulk wastewater) to other water services institutions within its respective service areas. They may perform other activities under conditions set out in the Water Services Act of 1997. Water boards’ revenues come from the municipalities they deliver services to. Not all municipalities have been paying for the services delivered to them, which led to the aim of this study being to gauge the perceptions of Water Board X and Water Board X’s customers of selected Customer Relationship Management (CRM) factors (service quality, customer involvement, customer value, information technology, and management commitment) that may possibly influence Revenue Management (RM). This could possibly assist Water Board X in the future to improve its revenue and debt collection. This thesis employed an interpretivist qualitative research methodology to explore its research aims and objectives. Open-ended semi-structured interviews were conducted with thirteen participants from Water Board X and four municipalities which Water Board X provides services. The data collected from the interviews were analysed manually through thematic analysis. The outcome of the interviews noted that an organisation that delivered high levels of service quality to its customers, could possibly improve its RM as the customers are of the opinion that their needs and requirements have been met and would be willing to pay for the services rendered. It was furthermore found that an organisation that involves its customers could possibly improve its RM as the organisation constantly communicates with its customers during, for example, the different stages of a project to ensure that the organisation does not deliver a project that does not meet the customers’ requirements at the end of the project life cycle. In addition the use of information technology played a pivotal in an organisation as the use of information technology assisted to develop effective methods in customer relationship management such as, data management, improving communication within the organisation, and with the customers, and the decision making. Furthermore, this study suggested the importance for an organisation to add value to the services that they deliver and for an organisation’s management to be committed to ensure that their customers’ expectations and requirements are met. The findings of the study suggest that CRM factors (service quality, customer involvement, customer value, information technology, and management commitment) could influence RM, and it is suggested that Water Board X adopts CRM strategies accordingly to improve its RM. Some of these strategies include adopting a coherent and sustainable revenue strategy through the use of appropriate tariff structures that are simple, equitable, affordable, financially sustainable, and transparent for all; showing commitment by prioritising water loss management and by properly auditing water supplies and water treatment revenue while increasing efficiency in supply and revenue recovery as this allowed Water Board X to better serve its customers, improve its financial standing, and allocate funding for water infrastructure upgrades and to adopt technologies that are on the market as these technologies can detect leakages, manage payments, control water flow and transmit data. , Thesis (MCom) -- Faculty of Commerce, Department of Management, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Manyonganise, Joshua Anesu
- Date: 2021-04
- Subjects: Customer relations -- Management , Revenue management -- South Africa -- Eastern Cape , Municipal government -- South Africa -- Eastern Cape , Municipal services -- South Africa -- Eastern Cape , Water-supply -- South Africa -- Eastern Cape , Amatola Water (Utility) , South Africa. National Water Act, 1998
- Language: English
- Type: thesis , text , Masters , MCom
- Identifier: http://hdl.handle.net/10962/177214 , vital:42800
- Description: The primary activity of water boards is to provide water services (bulk portable, and bulk wastewater) to other water services institutions within its respective service areas. They may perform other activities under conditions set out in the Water Services Act of 1997. Water boards’ revenues come from the municipalities they deliver services to. Not all municipalities have been paying for the services delivered to them, which led to the aim of this study being to gauge the perceptions of Water Board X and Water Board X’s customers of selected Customer Relationship Management (CRM) factors (service quality, customer involvement, customer value, information technology, and management commitment) that may possibly influence Revenue Management (RM). This could possibly assist Water Board X in the future to improve its revenue and debt collection. This thesis employed an interpretivist qualitative research methodology to explore its research aims and objectives. Open-ended semi-structured interviews were conducted with thirteen participants from Water Board X and four municipalities which Water Board X provides services. The data collected from the interviews were analysed manually through thematic analysis. The outcome of the interviews noted that an organisation that delivered high levels of service quality to its customers, could possibly improve its RM as the customers are of the opinion that their needs and requirements have been met and would be willing to pay for the services rendered. It was furthermore found that an organisation that involves its customers could possibly improve its RM as the organisation constantly communicates with its customers during, for example, the different stages of a project to ensure that the organisation does not deliver a project that does not meet the customers’ requirements at the end of the project life cycle. In addition the use of information technology played a pivotal in an organisation as the use of information technology assisted to develop effective methods in customer relationship management such as, data management, improving communication within the organisation, and with the customers, and the decision making. Furthermore, this study suggested the importance for an organisation to add value to the services that they deliver and for an organisation’s management to be committed to ensure that their customers’ expectations and requirements are met. The findings of the study suggest that CRM factors (service quality, customer involvement, customer value, information technology, and management commitment) could influence RM, and it is suggested that Water Board X adopts CRM strategies accordingly to improve its RM. Some of these strategies include adopting a coherent and sustainable revenue strategy through the use of appropriate tariff structures that are simple, equitable, affordable, financially sustainable, and transparent for all; showing commitment by prioritising water loss management and by properly auditing water supplies and water treatment revenue while increasing efficiency in supply and revenue recovery as this allowed Water Board X to better serve its customers, improve its financial standing, and allocate funding for water infrastructure upgrades and to adopt technologies that are on the market as these technologies can detect leakages, manage payments, control water flow and transmit data. , Thesis (MCom) -- Faculty of Commerce, Department of Management, 2021
- Full Text:
- Date Issued: 2021-04
Detection and effects of selected pharmaceutical compounds from selected water bodies in the Eastern Cape Province, South Africa
- Authors: Setshedi, Koketso Josinah
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/177074 , vital:42788
- Description: Theses embargoed. Release date March 2023. , Thesis (MSc) -- Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Setshedi, Koketso Josinah
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/177074 , vital:42788
- Description: Theses embargoed. Release date March 2023. , Thesis (MSc) -- Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2021
- Full Text:
- Date Issued: 2021-04
Development and assessment of rifampicin loaded self-microemulsifying drug delivery systems
- Authors: Mphaphuli, Mashudu Theodore
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178503 , vital:42945
- Description: Access restricted until April 2023. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Mphaphuli, Mashudu Theodore
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178503 , vital:42945
- Description: Access restricted until April 2023. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-04
Development and characterisation of ciprofloxacin hydrochloride solid lipid nanoparticles for ocular delivery
- Authors: Dhege, Clarence
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178446 , vital:42940
- Description: Access restricted until April 2023. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Dhege, Clarence
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178446 , vital:42940
- Description: Access restricted until April 2023. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-04
Does the Transkei population of Haliotis Midae at the eastern edge of its distributional range have a higher thermal tolerance than those in more temperate waters?
- Authors: Mathebula, Surprise
- Date: 2021-04
- Subjects: Haliotis midae -- South Africa -- Indian Coast , Abalones -- South Africa -- Indian Coast , Haliotis midae -- Effect of temperature on -- South Africa -- Indian Coast , Haliotis midae -- Physiology -- South Africa -- Indian Coast , Haliotis midae -- Adaptation -- South Africa -- Indian Coast , Haliotis midae -- Growth -- South Africa -- Indian Coast
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/177360 , vital:42814
- Description: The South African perlemoen abalone (Haliotis midae) may be vulnerable to rising temperatures on the East coast of South Africa due to climate change. H. midae is South Africa’s most valuable aquaculture species, and it is thus important to understand its physiological ability to adapt to the expected changes and to identify possible management measures to mitigate the impacts of rising temperatures. This project aimed to understand thermal tolerance and growth rates of offspring from two H. midae populations originating from the warm-temperate Central region (Port Elizabeth) and warmer Eastern edge of the species’ distribution in the Transkei region. To determine the effects of temperature on the physiological performance of the two abalone populations, growth rates, oxygen consumption rates and critical thermal maxima (CTM) were compared. A laboratory growth trial was conducted at three controlled temperatures, visibly, the ‘optimal’ temperature for H. midae growth (18 - 20℃), ‘pejus’ (stressful) temperature (21 - 22℃) and ‘critical’ temperature (23 - 24℃). Oxygen consumption rates were recorded at optimum (20℃), pejus (22℃) and critical (24℃) temperature using a respirometer. In addition, a farm growth trial with simultaneously spawned cohorts of abalone from the two populations was conducted at ambient temperature (19.5 and 20.0℃). The laboratory growth trial revealed no significant differences in growth rate between the two populations at the three temperature treatments (ANOVA, P > 0.05; df = 2). However, mortalities were high and growth rates low, indicating that the rearing conditions were sub-optimal, possibly masking genetic differences. No significant differences were observed in oxygen consumption rates (ANOVA, P = 0.18; df = 2), and CTM (t-Test, P = 0.31; df = 3) between the two populations. The CTM for both populations was between 29 - 30℃. The farm trial yielded no significant differences in growth rate during the Nursery phase (t-Test, P = 0.25; df = 2), however significant differences in growth rate were observed during the grow out phase with the Central region abalone offspring growing faster than the Eastern edge population (t-Test, P = 0.04; df = 4) indicating the possibility of a genetic difference between the two populations. Further experiments will be required to determine whether the differences observed in the growth trial were genetically or environmentally induced. , Thesis (MSc) -- Faculty of Science, Ichthyology and Fisheries Science, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Mathebula, Surprise
- Date: 2021-04
- Subjects: Haliotis midae -- South Africa -- Indian Coast , Abalones -- South Africa -- Indian Coast , Haliotis midae -- Effect of temperature on -- South Africa -- Indian Coast , Haliotis midae -- Physiology -- South Africa -- Indian Coast , Haliotis midae -- Adaptation -- South Africa -- Indian Coast , Haliotis midae -- Growth -- South Africa -- Indian Coast
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/177360 , vital:42814
- Description: The South African perlemoen abalone (Haliotis midae) may be vulnerable to rising temperatures on the East coast of South Africa due to climate change. H. midae is South Africa’s most valuable aquaculture species, and it is thus important to understand its physiological ability to adapt to the expected changes and to identify possible management measures to mitigate the impacts of rising temperatures. This project aimed to understand thermal tolerance and growth rates of offspring from two H. midae populations originating from the warm-temperate Central region (Port Elizabeth) and warmer Eastern edge of the species’ distribution in the Transkei region. To determine the effects of temperature on the physiological performance of the two abalone populations, growth rates, oxygen consumption rates and critical thermal maxima (CTM) were compared. A laboratory growth trial was conducted at three controlled temperatures, visibly, the ‘optimal’ temperature for H. midae growth (18 - 20℃), ‘pejus’ (stressful) temperature (21 - 22℃) and ‘critical’ temperature (23 - 24℃). Oxygen consumption rates were recorded at optimum (20℃), pejus (22℃) and critical (24℃) temperature using a respirometer. In addition, a farm growth trial with simultaneously spawned cohorts of abalone from the two populations was conducted at ambient temperature (19.5 and 20.0℃). The laboratory growth trial revealed no significant differences in growth rate between the two populations at the three temperature treatments (ANOVA, P > 0.05; df = 2). However, mortalities were high and growth rates low, indicating that the rearing conditions were sub-optimal, possibly masking genetic differences. No significant differences were observed in oxygen consumption rates (ANOVA, P = 0.18; df = 2), and CTM (t-Test, P = 0.31; df = 3) between the two populations. The CTM for both populations was between 29 - 30℃. The farm trial yielded no significant differences in growth rate during the Nursery phase (t-Test, P = 0.25; df = 2), however significant differences in growth rate were observed during the grow out phase with the Central region abalone offspring growing faster than the Eastern edge population (t-Test, P = 0.04; df = 4) indicating the possibility of a genetic difference between the two populations. Further experiments will be required to determine whether the differences observed in the growth trial were genetically or environmentally induced. , Thesis (MSc) -- Faculty of Science, Ichthyology and Fisheries Science, 2021
- Full Text:
- Date Issued: 2021-04
Economic impact of climate change on maize production in the Free State Province, South Africa
- Authors: Johnson, Richard Cowper
- Date: 2021-04
- Subjects: Corn -- Climatic factors -- South Africa -- Free State , Climatic changes -- Economic aspects -- South Africa -- Free State , Climate change mitigation -- South Africa -- Free State , Agriculture -- Economic aspects -- South Africa -- Free State
- Language: English
- Type: text , Thesis , Masters , MCom
- Identifier: http://hdl.handle.net/10962/174365 , vital:42471
- Description: Higher concentrations of CO2 in the atmosphere is a major influence on climate change globally. Climate change is caused by greenhouse gases trapping too much heat from the sun in the atmosphere and thus, altering the climate through a rise in global surface temperatures and changing precipitation patterns. CO2 is the most prominent greenhouse gas found in the atmosphere and it is reported that by the turn of the century the CO2 concentration levels will have doubled if the current rate of emissions continues. However, the increase in atmospheric levels of the gas has been found to increase the capacity of maize plants and their water use efficiency to achieve higher yields through CO2 fertilisation. Simulation experiments conducted by the Rhodes University Botany Department found that the effect of elevated levels of CO2 of double the current concentration offsets the negative effects of drought on maize. A case study was conducted on commercial maize farmers in two regions of the Free State province in South Africa to estimate the economic impact of climate change on maize production. Although production is increasing in the province, adaptation to the changing climate is key to the sustainability of production. There is a trade-off between the negative effects of higher CO2 levels changing the climate and the positive effect of CO2 fertilisation. As predicted, the economic impact of climate change is the disruption of farming practices and the increase in costs of production as a result of adapting to climate change. Using a gross margin analysis, the study found that the larger maize farmers who benefit from economies of scale are able to adapt and grow their production whilst the smaller farmers are being pushed out of the market.
- Full Text:
- Date Issued: 2021-04
- Authors: Johnson, Richard Cowper
- Date: 2021-04
- Subjects: Corn -- Climatic factors -- South Africa -- Free State , Climatic changes -- Economic aspects -- South Africa -- Free State , Climate change mitigation -- South Africa -- Free State , Agriculture -- Economic aspects -- South Africa -- Free State
- Language: English
- Type: text , Thesis , Masters , MCom
- Identifier: http://hdl.handle.net/10962/174365 , vital:42471
- Description: Higher concentrations of CO2 in the atmosphere is a major influence on climate change globally. Climate change is caused by greenhouse gases trapping too much heat from the sun in the atmosphere and thus, altering the climate through a rise in global surface temperatures and changing precipitation patterns. CO2 is the most prominent greenhouse gas found in the atmosphere and it is reported that by the turn of the century the CO2 concentration levels will have doubled if the current rate of emissions continues. However, the increase in atmospheric levels of the gas has been found to increase the capacity of maize plants and their water use efficiency to achieve higher yields through CO2 fertilisation. Simulation experiments conducted by the Rhodes University Botany Department found that the effect of elevated levels of CO2 of double the current concentration offsets the negative effects of drought on maize. A case study was conducted on commercial maize farmers in two regions of the Free State province in South Africa to estimate the economic impact of climate change on maize production. Although production is increasing in the province, adaptation to the changing climate is key to the sustainability of production. There is a trade-off between the negative effects of higher CO2 levels changing the climate and the positive effect of CO2 fertilisation. As predicted, the economic impact of climate change is the disruption of farming practices and the increase in costs of production as a result of adapting to climate change. Using a gross margin analysis, the study found that the larger maize farmers who benefit from economies of scale are able to adapt and grow their production whilst the smaller farmers are being pushed out of the market.
- Full Text:
- Date Issued: 2021-04
Exploring how Grade 9 Physical Science teachers mediate learning of the topic of chemical changes
- Likando, Orrice Munukayumbwa
- Authors: Likando, Orrice Munukayumbwa
- Date: 2021-04
- Subjects: Science -- Study and teaching (Secondary) -- Namibia , Chemistry -- Study and teaching (Secondary) -- Namibia , Culturally relevant pedagogy , Pedagogical content knowledge , Prior learning -- Namibia
- Language: English
- Type: thesis , text , Masters , MEd
- Identifier: http://hdl.handle.net/10962/177918 , vital:42890
- Description: The examiners’ reports for 2013-2018 indicated that learners consistently perform poorly in questions based on chemical changes. My assumption is that the reason why learners are challenged with understanding the topic of chemical changes could be due to the way this topic is taught. It is against this background that this study explored how grade 9 Physical Science teachers mediated learning of the topic of chemical changes. The study is underpinned by an interpretive paradigm. Within the interpretive paradigm, a qualitative case study research design was employed. It was conducted at two different schools in the Otjozondjupa region with two Physical Science teachers. Data were collected using semi-structured interviews, lesson observations, stimulated recall interviews, and teachers’ reflections. The study is informed by Vygotsky’s socio-cultural theory together with Shulman’s pedagogical content knowledge as the theoretical frameworks. A thematic approach to data analysis was adopted. That is, qualitative data were analysed inductively to come up with sub-themes to form themes. Moreover, validation and trustworthiness were completed through data triangulation, member checking, and watching videotaped lessons with the participants. The findings of this study revealed that the topic of chemical changes has many examples which can be used during mediation. Teachers seemed to be aware of integrating learners’ experiences into their lessons. Furthermore, they were aware that they should improvise resources during mediation of learning. In contrast, during lesson observations, the findings revealed an imbalance between this awareness and the actual knowledge of using easily accessible materials, and the elicitation and integration of prior knowledge throughout the science lessons. Moreover, hands-on practical activities were lacking in the mediation process and instead, traditional methods of teaching tended to dominate. Nonetheless, teachers’ reflections influenced them to analyse and strengthen their lessons. Thus, the study recommends that there is a need for teachers to have mentorships and platforms which can expose them to the knowledge of different types of easily accessible materials. This might strengthen their PCK. Teachers are also encouraged to do some reflections after very lesson as these have a potential to influence their pedagogical practices. , Thesis (MEd) -- Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Likando, Orrice Munukayumbwa
- Date: 2021-04
- Subjects: Science -- Study and teaching (Secondary) -- Namibia , Chemistry -- Study and teaching (Secondary) -- Namibia , Culturally relevant pedagogy , Pedagogical content knowledge , Prior learning -- Namibia
- Language: English
- Type: thesis , text , Masters , MEd
- Identifier: http://hdl.handle.net/10962/177918 , vital:42890
- Description: The examiners’ reports for 2013-2018 indicated that learners consistently perform poorly in questions based on chemical changes. My assumption is that the reason why learners are challenged with understanding the topic of chemical changes could be due to the way this topic is taught. It is against this background that this study explored how grade 9 Physical Science teachers mediated learning of the topic of chemical changes. The study is underpinned by an interpretive paradigm. Within the interpretive paradigm, a qualitative case study research design was employed. It was conducted at two different schools in the Otjozondjupa region with two Physical Science teachers. Data were collected using semi-structured interviews, lesson observations, stimulated recall interviews, and teachers’ reflections. The study is informed by Vygotsky’s socio-cultural theory together with Shulman’s pedagogical content knowledge as the theoretical frameworks. A thematic approach to data analysis was adopted. That is, qualitative data were analysed inductively to come up with sub-themes to form themes. Moreover, validation and trustworthiness were completed through data triangulation, member checking, and watching videotaped lessons with the participants. The findings of this study revealed that the topic of chemical changes has many examples which can be used during mediation. Teachers seemed to be aware of integrating learners’ experiences into their lessons. Furthermore, they were aware that they should improvise resources during mediation of learning. In contrast, during lesson observations, the findings revealed an imbalance between this awareness and the actual knowledge of using easily accessible materials, and the elicitation and integration of prior knowledge throughout the science lessons. Moreover, hands-on practical activities were lacking in the mediation process and instead, traditional methods of teaching tended to dominate. Nonetheless, teachers’ reflections influenced them to analyse and strengthen their lessons. Thus, the study recommends that there is a need for teachers to have mentorships and platforms which can expose them to the knowledge of different types of easily accessible materials. This might strengthen their PCK. Teachers are also encouraged to do some reflections after very lesson as these have a potential to influence their pedagogical practices. , Thesis (MEd) -- Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-04
Exploring the influences of an intersemiotic complementarity teaching approach on Grade 9 Namibian learners’ sense-making of chemical bonding
- Aikanga, Frans Paulus Shintaleleni
- Authors: Aikanga, Frans Paulus Shintaleleni
- Date: 2021-04
- Subjects: Physical sciences -- Study and teaching (Secondary) -- Namibia , Chemical bonds , Semiotics , Cognition in children , Communication in education , Language and education -- Namibia , Visual learning , Verbal learning
- Language: English
- Type: thesis , text , Masters , MEd
- Identifier: http://hdl.handle.net/10962/178281 , vital:42927
- Description: Anecdotal evidence from my 10 years’ experience teaching Grade 9 Physical Science in Namibian schools revealed learners’ difficulty with making sense of chemical bonding. The Junior Secondary examiners’ reports in recent consecutive years (2014, 2015, 2016 & 2017) also revealed this challenge among Grade 10 learners (Namibia. Ministry of Education, Arts and Culture [MoEAC], 2017). The language of learning and teaching (LoLT) for most school subjects (including Physical Science) in Namibia is English, which is taken as a second language by most learners (Kisting, 2011). The results of the English Language Proficiency test written by all principals and teachers in Namibia show that most are not proficient in this language (Kisting, 2011). This has raised concern as to how teaching of content subjects may be undertaken effectively with English as the LoLT. In Namibia, chemical bonding is part of the chemistry section of Physical Science, taught as a sub-topic under the Matter section, where the nature, characteristics, and behaviour of three states of matter are explained. The difficulty students have with chemical bonding is identified as being due to complex chemical concepts (Chittleborough & Mamiala, 2006), and the specialised language of the topic these concepts involve (Gilbert & Treagust, 2009). Additionally, this difficulty may be ascribed to lack of suitable pedagogic approaches, which is linked to science teachers not being fluent in the LoLT. Despite this link, Johnstone (1982) posits that addressing the challenge of teaching and learning chemical knowledge requires teachers’ understanding of three levels of representation: macroscopic, sub-microscopic, and symbolic. Addressing this challenge may be accomplished by using multimodality in teaching, which is achievable via intersemiosis of different semiotic modes, drawing from Systemic Functional Linguistics. This is due to non-linguistic modes also having the potential to make meaning as language does, and the fact that language alone cannot fully enable effective meaning-making in discourses that are inherently multimodal, such as science. Some studies have suggested that the intersemiosis of visual and verbal semiotic modes has the potential to enable more meaning-making of scientific discourse than either of these two alone. The study reported on in this thesis has built on such previous studies in order to explore the influences of a visual-verbal intersemiotic complementarity teaching approach on Grade 9 Namibian learners’ sense-making of chemical bonding. No studies from Namibia exploring these influences on Grade 9 learners could be found. This revealed the knowledge gap that this study aimed to contribute to filling. I accomplished this goal by embarking on a two-cycle action research study. The first cycle followed a traditional teaching approach and assessment, whereas the second cycle, the intervention, included a visual-verbal intersemiotic complementarity teaching approach and assessment. I achieved visual-verbal intersemiotic complementarity teaching and assessment by coordinating spoken and written language with visuals in the form of diagrams and physical models. The critical paradigm was adopted to explore the influences of this pedagogic approach, with the underlying aim of exploring the intervention approach for bringing about a change in learners’ sense-making of chemical bonding, compared to traditional approaches that do not consider intersemiosis. This study is informed by Vygotsky’s (1978) social constructivism to account for learning as a product of social construction, and Halliday’s (1978) Systemic Functional Linguistics to account for the role played by semiotic modes in making meanings. This study involved collecting qualitative data that were accessed via document analysis, structured lesson observation, the teacher’s and learners’ reflective journals, and the pre- and post-test. Collecting these data was facilitated by a critical friend. The results reveal a positive influence of the visual-verbal intersemiotic complementarity teaching approach on Grade 9 Namibian learners’ sense-making of chemical bonding. This influence was realised in the noticeable shift from the learners’ discourse (use of talk and visuals) being perceptual (which is less scientific) to being idea-based (which is more scientific). Learners were also found to be self-motivated and keen to learn complex chemical bonding concepts after the intervention – another sign of their making sense of the topic. The implications of this study include that visual-verbal intersemiotic complementarity should be considered a pedagogic approach to chemical bonding by curriculum developers and reviewers, teacher training institutions, and science textbook authors. , Thesis (MEd) -- Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Aikanga, Frans Paulus Shintaleleni
- Date: 2021-04
- Subjects: Physical sciences -- Study and teaching (Secondary) -- Namibia , Chemical bonds , Semiotics , Cognition in children , Communication in education , Language and education -- Namibia , Visual learning , Verbal learning
- Language: English
- Type: thesis , text , Masters , MEd
- Identifier: http://hdl.handle.net/10962/178281 , vital:42927
- Description: Anecdotal evidence from my 10 years’ experience teaching Grade 9 Physical Science in Namibian schools revealed learners’ difficulty with making sense of chemical bonding. The Junior Secondary examiners’ reports in recent consecutive years (2014, 2015, 2016 & 2017) also revealed this challenge among Grade 10 learners (Namibia. Ministry of Education, Arts and Culture [MoEAC], 2017). The language of learning and teaching (LoLT) for most school subjects (including Physical Science) in Namibia is English, which is taken as a second language by most learners (Kisting, 2011). The results of the English Language Proficiency test written by all principals and teachers in Namibia show that most are not proficient in this language (Kisting, 2011). This has raised concern as to how teaching of content subjects may be undertaken effectively with English as the LoLT. In Namibia, chemical bonding is part of the chemistry section of Physical Science, taught as a sub-topic under the Matter section, where the nature, characteristics, and behaviour of three states of matter are explained. The difficulty students have with chemical bonding is identified as being due to complex chemical concepts (Chittleborough & Mamiala, 2006), and the specialised language of the topic these concepts involve (Gilbert & Treagust, 2009). Additionally, this difficulty may be ascribed to lack of suitable pedagogic approaches, which is linked to science teachers not being fluent in the LoLT. Despite this link, Johnstone (1982) posits that addressing the challenge of teaching and learning chemical knowledge requires teachers’ understanding of three levels of representation: macroscopic, sub-microscopic, and symbolic. Addressing this challenge may be accomplished by using multimodality in teaching, which is achievable via intersemiosis of different semiotic modes, drawing from Systemic Functional Linguistics. This is due to non-linguistic modes also having the potential to make meaning as language does, and the fact that language alone cannot fully enable effective meaning-making in discourses that are inherently multimodal, such as science. Some studies have suggested that the intersemiosis of visual and verbal semiotic modes has the potential to enable more meaning-making of scientific discourse than either of these two alone. The study reported on in this thesis has built on such previous studies in order to explore the influences of a visual-verbal intersemiotic complementarity teaching approach on Grade 9 Namibian learners’ sense-making of chemical bonding. No studies from Namibia exploring these influences on Grade 9 learners could be found. This revealed the knowledge gap that this study aimed to contribute to filling. I accomplished this goal by embarking on a two-cycle action research study. The first cycle followed a traditional teaching approach and assessment, whereas the second cycle, the intervention, included a visual-verbal intersemiotic complementarity teaching approach and assessment. I achieved visual-verbal intersemiotic complementarity teaching and assessment by coordinating spoken and written language with visuals in the form of diagrams and physical models. The critical paradigm was adopted to explore the influences of this pedagogic approach, with the underlying aim of exploring the intervention approach for bringing about a change in learners’ sense-making of chemical bonding, compared to traditional approaches that do not consider intersemiosis. This study is informed by Vygotsky’s (1978) social constructivism to account for learning as a product of social construction, and Halliday’s (1978) Systemic Functional Linguistics to account for the role played by semiotic modes in making meanings. This study involved collecting qualitative data that were accessed via document analysis, structured lesson observation, the teacher’s and learners’ reflective journals, and the pre- and post-test. Collecting these data was facilitated by a critical friend. The results reveal a positive influence of the visual-verbal intersemiotic complementarity teaching approach on Grade 9 Namibian learners’ sense-making of chemical bonding. This influence was realised in the noticeable shift from the learners’ discourse (use of talk and visuals) being perceptual (which is less scientific) to being idea-based (which is more scientific). Learners were also found to be self-motivated and keen to learn complex chemical bonding concepts after the intervention – another sign of their making sense of the topic. The implications of this study include that visual-verbal intersemiotic complementarity should be considered a pedagogic approach to chemical bonding by curriculum developers and reviewers, teacher training institutions, and science textbook authors. , Thesis (MEd) -- Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-04
Framing realities : a critical analysis of perspectival distortion in the film Alice by Czech Surrealist Jan Švankmajer
- Authors: Soutter, Simone
- Date: 2021-04
- Subjects: Švankmajer, Jan, 1934- -- Criticism and interpretation , Depression, Mental -- Exhibitions , Perception , Frames (Sociology) , Surrealism -- Influence , Cubism -- Influence , Surrealism in motion pictures , Depression, Mental in art
- Language: English
- Type: thesis , text , Masters , MFA
- Identifier: http://hdl.handle.net/10962/178365 , vital:42933
- Description: My MFA exhibition Through the looking glass; altered states of perception, explores my experience of mental distress: Major Depressive Disorder (MDD), through the medium of painting and multimedia collage. Situated in the Main Fine Art building on Rhodes University campus, this practical submission takes the form of a collection of oil paintings accompanied by an immersive wall of collaged experimentations, depicting the perspectival shifts I have experienced in coping with mental distress. The paintings explore concepts of framing and perspective, both literally and metaphorically in unpacking how our perceptions are manipulated by the way in which situations and concepts are framed. I use strategies and techniques drawn from the Surrealist and Cubist movements in order to depict my distorted experience of time and space, but also to tap into my own unconscious. In this mini-thesis: Framing realities; A critical analysis of perspectival distortion in the film Alice by Czech Surrealist Jan Švankmajer, I explore the strategies and concepts developed during the Surrealist and Cubist movements in relation to strategies used by Švankmajer in his disturbing interpretation of Alice’s Adventures into Wonderland. Here, he visually explores the psyche of an imaginative child. His unique interpretation is expressed through the combination of live-action film and stop-motion animation. I position my work in relation to themes proposed by Maurice Merleau-Ponty, Ernst Jentch, Sigmund Freud and Julia Kristeva. In the first Chapter: Framing and Perspectival shifts, I unpack framing and perspectival shifts exhibited in the Cubist (a physical shift), Dadaist (a social shift), and Surrealist (an unconscious shift) movements. In Chapter Two: A critical analysis of Alice by Jan Švankmajer, I engage in an analysis of themes (examined in the above art movements) relative to the film Alice. These are found objects and assemblages, ambiguity, distortion of scale, the Unconscious, the uncanny and multi-sensory modalities. Chapter Three: Through the Looking Glass; Altered states of perception, I discuss how the themes discussed in Chapter Two apply to my own body of work and how these themes are addressed with regards to my lived experience of mental disorder and distress. , Thesis (MFA) -- Faculty of Humanities, Fine Arts, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Soutter, Simone
- Date: 2021-04
- Subjects: Švankmajer, Jan, 1934- -- Criticism and interpretation , Depression, Mental -- Exhibitions , Perception , Frames (Sociology) , Surrealism -- Influence , Cubism -- Influence , Surrealism in motion pictures , Depression, Mental in art
- Language: English
- Type: thesis , text , Masters , MFA
- Identifier: http://hdl.handle.net/10962/178365 , vital:42933
- Description: My MFA exhibition Through the looking glass; altered states of perception, explores my experience of mental distress: Major Depressive Disorder (MDD), through the medium of painting and multimedia collage. Situated in the Main Fine Art building on Rhodes University campus, this practical submission takes the form of a collection of oil paintings accompanied by an immersive wall of collaged experimentations, depicting the perspectival shifts I have experienced in coping with mental distress. The paintings explore concepts of framing and perspective, both literally and metaphorically in unpacking how our perceptions are manipulated by the way in which situations and concepts are framed. I use strategies and techniques drawn from the Surrealist and Cubist movements in order to depict my distorted experience of time and space, but also to tap into my own unconscious. In this mini-thesis: Framing realities; A critical analysis of perspectival distortion in the film Alice by Czech Surrealist Jan Švankmajer, I explore the strategies and concepts developed during the Surrealist and Cubist movements in relation to strategies used by Švankmajer in his disturbing interpretation of Alice’s Adventures into Wonderland. Here, he visually explores the psyche of an imaginative child. His unique interpretation is expressed through the combination of live-action film and stop-motion animation. I position my work in relation to themes proposed by Maurice Merleau-Ponty, Ernst Jentch, Sigmund Freud and Julia Kristeva. In the first Chapter: Framing and Perspectival shifts, I unpack framing and perspectival shifts exhibited in the Cubist (a physical shift), Dadaist (a social shift), and Surrealist (an unconscious shift) movements. In Chapter Two: A critical analysis of Alice by Jan Švankmajer, I engage in an analysis of themes (examined in the above art movements) relative to the film Alice. These are found objects and assemblages, ambiguity, distortion of scale, the Unconscious, the uncanny and multi-sensory modalities. Chapter Three: Through the Looking Glass; Altered states of perception, I discuss how the themes discussed in Chapter Two apply to my own body of work and how these themes are addressed with regards to my lived experience of mental disorder and distress. , Thesis (MFA) -- Faculty of Humanities, Fine Arts, 2021
- Full Text:
- Date Issued: 2021-04
Healthcare issues in disaster management : preparedness in the pharmacy profession
- Authors: Vhiriri, Eunice Paidamoyo
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178591 , vital:42953
- Description: Access restricted until April 2023. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Vhiriri, Eunice Paidamoyo
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178591 , vital:42953
- Description: Access restricted until April 2023. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-04
Hierdie keer gaan nie maklik wees nie
- Authors: Visser, Deon Claudius
- Date: 2021-04
- Subjects: Creative writing (Higher education) -- South Africa , Diaries -- Authorship , Short stories, Afrikaans -- 21st century , Afrikaans fiction -- 21st century , Afrikaans fiction -- History and criticism
- Language: Afrikaans
- Type: thesis , text , Masters , MA
- Identifier: http://hdl.handle.net/10962/178317 , vital:42929
- Description: My tesis bestaan uit twee versamelings van prosa wat verwant en in noue verband met mekaar tree. Die prosa is fragmentaries en kort maar verbind met ‟n oorkoepelende storie wat in beide Afrikaans en Engels voorgelê word. Die Afrikaanse deel van my tesis ondersoek die verlede, en die Engels die toekoms. My algemene bron van inspirasie vir die struktuur en voorlegging van die tesis word verkry vanaf die klassieke raamverteller konvensie soos gebruik in One Thousand and One Nights, hierdie konvensie maak gebruik van raamfragmente wat binne ‟n groter geheel gevind kan word. Dit is juis hierdie komplekse struktuur wat dit moontlik maak om tyd, hede en verlede asook die toekoms, te kan ondersoek en uit te beeld. Verder maak dit dit ook moontlik om gekoppelde herinneringe, gedagteneigings, en fantasieverhale te kan gebruik as die dryfkrag van die oorkoepelende storie. Met betrekking tot kontemporêre fiksie vind ek die meeste aanklank en invloed by Sandra Cisneros se boek House on Mango Street. Ek het by hierdie verhaal geleer hoe om vignette en kortverhale onafhanklik maar met ‟n motief-verbinding aan mekaar te koppel. Tematies gesproke handel my tesis oor herinneringe, nostalgie, familieverhoudings, die dood asook afsluiting en aanbeweging. In terme van hierdie temas vind ek dat Nathan Trantraal se Chokers en Survivors, en Noudat Slapende Honde deur Ronelda S. Kamfer my die meeste insae gee oor die verhouding tussen Afrikaans en Engels in die literatuur. Verder is Loftus Marais se taalgebruik en die vermenging van taal in Staan in die Algemeen Nader aan Vensters ook insiggewend. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Visser, Deon Claudius
- Date: 2021-04
- Subjects: Creative writing (Higher education) -- South Africa , Diaries -- Authorship , Short stories, Afrikaans -- 21st century , Afrikaans fiction -- 21st century , Afrikaans fiction -- History and criticism
- Language: Afrikaans
- Type: thesis , text , Masters , MA
- Identifier: http://hdl.handle.net/10962/178317 , vital:42929
- Description: My tesis bestaan uit twee versamelings van prosa wat verwant en in noue verband met mekaar tree. Die prosa is fragmentaries en kort maar verbind met ‟n oorkoepelende storie wat in beide Afrikaans en Engels voorgelê word. Die Afrikaanse deel van my tesis ondersoek die verlede, en die Engels die toekoms. My algemene bron van inspirasie vir die struktuur en voorlegging van die tesis word verkry vanaf die klassieke raamverteller konvensie soos gebruik in One Thousand and One Nights, hierdie konvensie maak gebruik van raamfragmente wat binne ‟n groter geheel gevind kan word. Dit is juis hierdie komplekse struktuur wat dit moontlik maak om tyd, hede en verlede asook die toekoms, te kan ondersoek en uit te beeld. Verder maak dit dit ook moontlik om gekoppelde herinneringe, gedagteneigings, en fantasieverhale te kan gebruik as die dryfkrag van die oorkoepelende storie. Met betrekking tot kontemporêre fiksie vind ek die meeste aanklank en invloed by Sandra Cisneros se boek House on Mango Street. Ek het by hierdie verhaal geleer hoe om vignette en kortverhale onafhanklik maar met ‟n motief-verbinding aan mekaar te koppel. Tematies gesproke handel my tesis oor herinneringe, nostalgie, familieverhoudings, die dood asook afsluiting en aanbeweging. In terme van hierdie temas vind ek dat Nathan Trantraal se Chokers en Survivors, en Noudat Slapende Honde deur Ronelda S. Kamfer my die meeste insae gee oor die verhouding tussen Afrikaans en Engels in die literatuur. Verder is Loftus Marais se taalgebruik en die vermenging van taal in Staan in die Algemeen Nader aan Vensters ook insiggewend. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
- Full Text:
- Date Issued: 2021-04
How selected Grade 7 participants develop conceptual understanding in solving algebraic problems as a result of participating in a screencast intervention
- Authors: Wienekus, George Renier
- Date: 2021-04
- Subjects: Algebra -- Study and teaching -- South Africa , Mathematics -- Study and teaching (Elementary) -- South Africa , Problem solving in children , Algebra -- Ability testing , Algebra -- Computer-assisted instruction
- Language: English
- Type: thesis , text , Masters , MEd
- Identifier: http://hdl.handle.net/10962/176833 , vital:42763
- Description: This research project is an interventionist case study, oriented in the interpretive paradigm, which aims to investigate how selected Grade 7 participants develop conceptual understanding in solving algebraic problems as a result of participating in screencast interventions. The aim of my screencast intervention programme, which lies at the heart of this study, is to develop practices, inter alia, of how such devices and software may be “used to develop conceptual rather than procedural or decorative knowledge” (Larkin & Calder, 2015:1) in solving linear equations. The planned intervention was delivered in the form of a series of screencasts: these take the form of audio-video lessons with an emphasis on the visual impact, and were recorded using an application called Explain Everything. The screencast interventions were delivered via Google Classroom and included animations supported by such conceptual explanations of early algebra as are relevant to Grade 7 students, and in line with the South African Curriculum and Assessment Policy Statements - Department of Education, 2011. The fundamental components of an early algebraic equation that would be relevant to a Grade 7 student were considered and used to develop an analytic framework. This was based on a taxonomy designed according to four identified “clusters” in order to analyse the workings of the purposefully selected Grade 7 participants who were video recorded and questioned in a talk-aloud interview while they completed a post-intervention pencil-and-paper test. What emerges from this research project is that there is a significant need for specific and concentrated technology-based techniques, such as the interventions undertaken here, and that exploration and development in the field could benefit the delivery of a pedagogy for algebra. The pedagogical methods implemented and studied in the form of screencasts proved to be successful and were well received by the learners particularly in relation to the conceptualisation of “symbol sense” and transformation in early algebra. The structure and design of the screencast interventions were important in supporting the acquisition of these concepts and were demonstrated to be worthwhile tools for an epistemological application in a classroom or teaching context. , Thesis (MEd) -- Rhodes University, Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Wienekus, George Renier
- Date: 2021-04
- Subjects: Algebra -- Study and teaching -- South Africa , Mathematics -- Study and teaching (Elementary) -- South Africa , Problem solving in children , Algebra -- Ability testing , Algebra -- Computer-assisted instruction
- Language: English
- Type: thesis , text , Masters , MEd
- Identifier: http://hdl.handle.net/10962/176833 , vital:42763
- Description: This research project is an interventionist case study, oriented in the interpretive paradigm, which aims to investigate how selected Grade 7 participants develop conceptual understanding in solving algebraic problems as a result of participating in screencast interventions. The aim of my screencast intervention programme, which lies at the heart of this study, is to develop practices, inter alia, of how such devices and software may be “used to develop conceptual rather than procedural or decorative knowledge” (Larkin & Calder, 2015:1) in solving linear equations. The planned intervention was delivered in the form of a series of screencasts: these take the form of audio-video lessons with an emphasis on the visual impact, and were recorded using an application called Explain Everything. The screencast interventions were delivered via Google Classroom and included animations supported by such conceptual explanations of early algebra as are relevant to Grade 7 students, and in line with the South African Curriculum and Assessment Policy Statements - Department of Education, 2011. The fundamental components of an early algebraic equation that would be relevant to a Grade 7 student were considered and used to develop an analytic framework. This was based on a taxonomy designed according to four identified “clusters” in order to analyse the workings of the purposefully selected Grade 7 participants who were video recorded and questioned in a talk-aloud interview while they completed a post-intervention pencil-and-paper test. What emerges from this research project is that there is a significant need for specific and concentrated technology-based techniques, such as the interventions undertaken here, and that exploration and development in the field could benefit the delivery of a pedagogy for algebra. The pedagogical methods implemented and studied in the form of screencasts proved to be successful and were well received by the learners particularly in relation to the conceptualisation of “symbol sense” and transformation in early algebra. The structure and design of the screencast interventions were important in supporting the acquisition of these concepts and were demonstrated to be worthwhile tools for an epistemological application in a classroom or teaching context. , Thesis (MEd) -- Rhodes University, Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-04
Impact of sovereign credit ratings on emerging bond and stock market returns
- Authors: Mkhonto, Zoyisile
- Date: 2021-04
- Subjects: Rating agencies (Finance) , Credit ratings , Bond market
- Language: English
- Type: thesis , text , Masters , MCom
- Identifier: http://hdl.handle.net/10962/177170 , vital:42796
- Description: The primary role of credit rating agencies is to reduce asymmetric information between the parties in a lending relationship. The three major rating agencies have received extensive criticism over the years. These rating agencies have been accused of providing inaccurate ratings which ultimately led to various financial calamities. Late rating action has also been blamed for exacerbating financial and economic cycles. Moreover, there is an argument that emerging markets are unfairly rated in comparison to developed economies. Hence, the reliability and informational value of the assessments provided by credit rating agencies is met with scepticism. Despite these criticisms, rating agencies are characterised as gatekeepers to capital and credit ratings remain essential financial market indicators. Albeit, the literature regarding the impact of sovereign credit ratings on bond and stock markets is inconclusive. This study aims to add to the body of literature and provide insights into the informational value of sovereign credit ratings in emerging markets. More specifically to estimate the relationship between various sovereign credit rating announcements, and bond and stock market returns. Also, to examine whether sovereign credit ratings have a differential impact between bond and stock markets. As well as address the question does it matter who provides the rating? Using an event study, abnormal returns surrounding rating announcements from 2009 to 2019 for 24 emerging markets were analyzed. Firstly, this study concluded that sovereign credit ratings are informative. Secondly, the degree of informativeness differs between the bond and stock markets. Thirdly, an asymmetrical impact was observed between the types of rating announcements. Lastly, that it does matter which rating agency provides the rating because each agency has a unique reputation. The findings of this research have implications on how investors and portfolio managers decide on asset allocation. Furthermore, policymakers may find our investment grade analysis of value when evaluating regulatory reform. It’s recommended that future research refines the event methodology and examines country specific characteristics within each of the emerging markets. , Thesis (MCom) -- Faculty of Commerce, Economics and Economic History, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Mkhonto, Zoyisile
- Date: 2021-04
- Subjects: Rating agencies (Finance) , Credit ratings , Bond market
- Language: English
- Type: thesis , text , Masters , MCom
- Identifier: http://hdl.handle.net/10962/177170 , vital:42796
- Description: The primary role of credit rating agencies is to reduce asymmetric information between the parties in a lending relationship. The three major rating agencies have received extensive criticism over the years. These rating agencies have been accused of providing inaccurate ratings which ultimately led to various financial calamities. Late rating action has also been blamed for exacerbating financial and economic cycles. Moreover, there is an argument that emerging markets are unfairly rated in comparison to developed economies. Hence, the reliability and informational value of the assessments provided by credit rating agencies is met with scepticism. Despite these criticisms, rating agencies are characterised as gatekeepers to capital and credit ratings remain essential financial market indicators. Albeit, the literature regarding the impact of sovereign credit ratings on bond and stock markets is inconclusive. This study aims to add to the body of literature and provide insights into the informational value of sovereign credit ratings in emerging markets. More specifically to estimate the relationship between various sovereign credit rating announcements, and bond and stock market returns. Also, to examine whether sovereign credit ratings have a differential impact between bond and stock markets. As well as address the question does it matter who provides the rating? Using an event study, abnormal returns surrounding rating announcements from 2009 to 2019 for 24 emerging markets were analyzed. Firstly, this study concluded that sovereign credit ratings are informative. Secondly, the degree of informativeness differs between the bond and stock markets. Thirdly, an asymmetrical impact was observed between the types of rating announcements. Lastly, that it does matter which rating agency provides the rating because each agency has a unique reputation. The findings of this research have implications on how investors and portfolio managers decide on asset allocation. Furthermore, policymakers may find our investment grade analysis of value when evaluating regulatory reform. It’s recommended that future research refines the event methodology and examines country specific characteristics within each of the emerging markets. , Thesis (MCom) -- Faculty of Commerce, Economics and Economic History, 2021
- Full Text:
- Date Issued: 2021-04
In My Flesh : Fabricating the Bulimic Body
- Authors: Hodgson, Ashley
- Date: 2021-04
- Subjects: Bulimia , Human body -- Social aspects , Human figure in art , Diseases in art , Art therapy
- Language: English
- Type: thesis , text , Masters , MFA
- Identifier: http://hdl.handle.net/10962/177317 , vital:42809
- Description: My MFA exhibition In My Flesh, explores my own personal experience of an eating disorder: bulimia nervosa, through the medium of sculpture and installation. Situated in the Fine Art Sculpture and Painting building on Rhodes University campus, this practical submission takes the form of a multi-sensory installation depicting the fleshy interior of a bulimic body. The sculptural works that make up the installation resemble enlarged bodily forms and cavities, namely the mouth; the oesophagus, the stomach; the intestines; and the flesh. These anatomical forms are made from fabric which has been melted, manipulated, and stained using food and other synthetic dyes. The arrangement of the sculptural components (parts of the body affected by bulimia) does not mirror the human body exactly, and their intentionally disordered placement creates a feeling of dis-ease and disturbance for the participant experiencing the installation. This mini-thesis, In My Flesh: Fabricating the Bulimic Body, unpacks the visual, tactile and audio elements of this practice as research submission as they relate to my interest in bodily boundaries, corporeal traces and material extensions. I look at these themes as they translate into installation, and discuss the way in which bulimia is experienced, theorised and represented. I position my work in relation to the concept of the abject as proposed by Julia Kristeva, and visually analyse artworks by Mona Hatoum, Heidi Bucher and Ernesto Neto who make use of immersive installation strategies that resonate with my own practice. This supporting document considers the three conceptual elements informing my installation: embodiment, space, and materiality. In the first chapter of this document: Embodying the Bulimic Body, I address bulimia as less open to visual interpretations than other eating disorders because of its secretive and hidden nature. I go on to frame the illness in relation to theories around bodily boundaries and abjection and argue that bulimia epitomises abjection. In Chapter Two: Architecture of the Bulimic Body I engage with the idea of architectural structures as having anatomic features. I interrogate how the body moves through space, leaving traces of itself behind. Chapter Three: Fabricating the Bulimic Body concentrates on the main medium used in In My Flesh: fabric. In my discussion of this material, I unpack its metaphoric and symbolic qualities, as well as its personal resonance with my own lived experience. , Thesis (MFA) -- Faculty of Humanities, Fine Art, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Hodgson, Ashley
- Date: 2021-04
- Subjects: Bulimia , Human body -- Social aspects , Human figure in art , Diseases in art , Art therapy
- Language: English
- Type: thesis , text , Masters , MFA
- Identifier: http://hdl.handle.net/10962/177317 , vital:42809
- Description: My MFA exhibition In My Flesh, explores my own personal experience of an eating disorder: bulimia nervosa, through the medium of sculpture and installation. Situated in the Fine Art Sculpture and Painting building on Rhodes University campus, this practical submission takes the form of a multi-sensory installation depicting the fleshy interior of a bulimic body. The sculptural works that make up the installation resemble enlarged bodily forms and cavities, namely the mouth; the oesophagus, the stomach; the intestines; and the flesh. These anatomical forms are made from fabric which has been melted, manipulated, and stained using food and other synthetic dyes. The arrangement of the sculptural components (parts of the body affected by bulimia) does not mirror the human body exactly, and their intentionally disordered placement creates a feeling of dis-ease and disturbance for the participant experiencing the installation. This mini-thesis, In My Flesh: Fabricating the Bulimic Body, unpacks the visual, tactile and audio elements of this practice as research submission as they relate to my interest in bodily boundaries, corporeal traces and material extensions. I look at these themes as they translate into installation, and discuss the way in which bulimia is experienced, theorised and represented. I position my work in relation to the concept of the abject as proposed by Julia Kristeva, and visually analyse artworks by Mona Hatoum, Heidi Bucher and Ernesto Neto who make use of immersive installation strategies that resonate with my own practice. This supporting document considers the three conceptual elements informing my installation: embodiment, space, and materiality. In the first chapter of this document: Embodying the Bulimic Body, I address bulimia as less open to visual interpretations than other eating disorders because of its secretive and hidden nature. I go on to frame the illness in relation to theories around bodily boundaries and abjection and argue that bulimia epitomises abjection. In Chapter Two: Architecture of the Bulimic Body I engage with the idea of architectural structures as having anatomic features. I interrogate how the body moves through space, leaving traces of itself behind. Chapter Three: Fabricating the Bulimic Body concentrates on the main medium used in In My Flesh: fabric. In my discussion of this material, I unpack its metaphoric and symbolic qualities, as well as its personal resonance with my own lived experience. , Thesis (MFA) -- Faculty of Humanities, Fine Art, 2021
- Full Text:
- Date Issued: 2021-04
In silico identification of selective novel hits against the active site of wild type mycobacterium tuberculosis pyrazinamidase and its mutants
- Authors: Gowo, Prudence
- Date: 2021-04
- Subjects: Mycobacterium tuberculosis , Pyrazinamide , Multidrug resistance , Antitubercular agents , Molecular dynamics , Hydrogen bonding , Ligand binding (Biochemistry) , Dynamic Residue Network
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178007 , vital:42898
- Description: The World Health Organization declared Tuberculosis a global health emergency and has set a goal to eradicate it by 2035. However, effective treatment and control of the disease is being hindered by the emerging Multi-Drug Resistant and Extensively Drug Resistant strains on the most effective first line prodrug, Pyrazinamide (PZA). Studies have shown that the main cause of PZA resistance is due to mutations in the pncA gene that codes for the target protein Pyrazinamidase (PZase). Therefore, this study aimed to identify novel drug compounds that bind to the active site of wild type PZase and study the dynamics of these potential anti-TB drugs in the mutant systems of PZase. This approach will aid in identifying drugs that may be repurposed for TB therapy and/or designed to counteract PZA resistance. This was achieved by screening 2089 DrugBank compounds against the whole wild type (WT) PZase protein in molecular docking using AutoDOCK4.2. Compound screening based on docking binding energy, hydrogen bonds, molecular weight and active site proximity identified 47 compounds meeting all the set selection criteria. The stability of these compounds were analysed in Molecular Dynamic (MD) simulations and were further studied in PZase mutant systems of A3P, A134V, A146V, D8G, D49A, D49G, D63G, H51P, H137R, L85R, L116R, Q10P, R140S, T61P, V139M and Y103S. Generally, mutant-ligand systems displayed little deviation from the WT systems. The compound systems remained compact, with less fluctuations and more hydrogen bond interactions throughout the simulation (DB00255, DB00655, DB00672, DB00782, DB00977, DB01196, DB04573, DB06414, DB08981, DB11181, DB11760, DB13867, DB13952). From this research study, potential drugs that may be repurposed for TB therapy were identified. Majority of these drugs are currently used in the treatment of hypertension, menopause disorders and inflammation. To further understand the mutant-ligand dynamic systems, calculations such as Dynamic Residue Network (DRN) may be done. Also, the bioactivity of these drugs on Mycobacterium tuberculosis may be studied in wet laboratory, to understand their clinical impart in vivo experiments. , Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Gowo, Prudence
- Date: 2021-04
- Subjects: Mycobacterium tuberculosis , Pyrazinamide , Multidrug resistance , Antitubercular agents , Molecular dynamics , Hydrogen bonding , Ligand binding (Biochemistry) , Dynamic Residue Network
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178007 , vital:42898
- Description: The World Health Organization declared Tuberculosis a global health emergency and has set a goal to eradicate it by 2035. However, effective treatment and control of the disease is being hindered by the emerging Multi-Drug Resistant and Extensively Drug Resistant strains on the most effective first line prodrug, Pyrazinamide (PZA). Studies have shown that the main cause of PZA resistance is due to mutations in the pncA gene that codes for the target protein Pyrazinamidase (PZase). Therefore, this study aimed to identify novel drug compounds that bind to the active site of wild type PZase and study the dynamics of these potential anti-TB drugs in the mutant systems of PZase. This approach will aid in identifying drugs that may be repurposed for TB therapy and/or designed to counteract PZA resistance. This was achieved by screening 2089 DrugBank compounds against the whole wild type (WT) PZase protein in molecular docking using AutoDOCK4.2. Compound screening based on docking binding energy, hydrogen bonds, molecular weight and active site proximity identified 47 compounds meeting all the set selection criteria. The stability of these compounds were analysed in Molecular Dynamic (MD) simulations and were further studied in PZase mutant systems of A3P, A134V, A146V, D8G, D49A, D49G, D63G, H51P, H137R, L85R, L116R, Q10P, R140S, T61P, V139M and Y103S. Generally, mutant-ligand systems displayed little deviation from the WT systems. The compound systems remained compact, with less fluctuations and more hydrogen bond interactions throughout the simulation (DB00255, DB00655, DB00672, DB00782, DB00977, DB01196, DB04573, DB06414, DB08981, DB11181, DB11760, DB13867, DB13952). From this research study, potential drugs that may be repurposed for TB therapy were identified. Majority of these drugs are currently used in the treatment of hypertension, menopause disorders and inflammation. To further understand the mutant-ligand dynamic systems, calculations such as Dynamic Residue Network (DRN) may be done. Also, the bioactivity of these drugs on Mycobacterium tuberculosis may be studied in wet laboratory, to understand their clinical impart in vivo experiments. , Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-04
Inhibitor search and variant analysis of Acetylcholinesterase
- Authors: Ras, Harnaud
- Date: 2021-04
- Subjects: Acetylcholinesterase , Alzheimer's disease , Acetylcholinesterase -- Inhibitors , Alzheimer's disease -- Chemotherapy , Cerebrovascular disease -- Treatment , Molecular mechanics Poisson–Boltzmann surface area (MM-PBSA)
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178191 , vital:42919
- Description: Acetylcholinesterase (AChE) inhibition is used to treat Alzheimer's disease by increasing the availability of acetylcholine to carry nerve signals in the brain. The response to this treatment varies widely, which may be due to altered affnity to the current drugs caused by genetic variation. Various negative side-effects limit their use. As this is one of the only available therapeutic drug targets to treat Alzheimer's disease, decreasing the negative effects is of great importance. AChE is involved in biological processes that occur after acute ischemic stroke. Stroke is the third leading cause of death worldwide, and 87% of all stroke cases belong to ischemic stroke. AchEI (cholinesterase inhibitors) have been suggested to have properties that lower the risk of stroke. AChE is one of 15 verified drug targets under study for treatment of stroke. In addition to Alzheimer's disease and stroke, Lewy body disease (LBD) may be treated using cholinesterase inhibitors. The goals of this study are to find inhibitors that can potentially be used to treat Alzheimer's disease and/or stroke and to investigate variants which may affect protein dynamics and function. Two variants were analyzed, P247L and T229S. Molecular simulation of the P247L variant resulted in a disruption in protein dynamics in comparison to the wildtype. A total of 5728 molecules were screened and 10 nanosecond simulations were used to narrow down the set of compounds. The four best performing molecules were simulated for 10 nanoseconds. MM-PBSA was performed to identify molecules with high binding free energies. , Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Ras, Harnaud
- Date: 2021-04
- Subjects: Acetylcholinesterase , Alzheimer's disease , Acetylcholinesterase -- Inhibitors , Alzheimer's disease -- Chemotherapy , Cerebrovascular disease -- Treatment , Molecular mechanics Poisson–Boltzmann surface area (MM-PBSA)
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178191 , vital:42919
- Description: Acetylcholinesterase (AChE) inhibition is used to treat Alzheimer's disease by increasing the availability of acetylcholine to carry nerve signals in the brain. The response to this treatment varies widely, which may be due to altered affnity to the current drugs caused by genetic variation. Various negative side-effects limit their use. As this is one of the only available therapeutic drug targets to treat Alzheimer's disease, decreasing the negative effects is of great importance. AChE is involved in biological processes that occur after acute ischemic stroke. Stroke is the third leading cause of death worldwide, and 87% of all stroke cases belong to ischemic stroke. AchEI (cholinesterase inhibitors) have been suggested to have properties that lower the risk of stroke. AChE is one of 15 verified drug targets under study for treatment of stroke. In addition to Alzheimer's disease and stroke, Lewy body disease (LBD) may be treated using cholinesterase inhibitors. The goals of this study are to find inhibitors that can potentially be used to treat Alzheimer's disease and/or stroke and to investigate variants which may affect protein dynamics and function. Two variants were analyzed, P247L and T229S. Molecular simulation of the P247L variant resulted in a disruption in protein dynamics in comparison to the wildtype. A total of 5728 molecules were screened and 10 nanosecond simulations were used to narrow down the set of compounds. The four best performing molecules were simulated for 10 nanoseconds. MM-PBSA was performed to identify molecules with high binding free energies. , Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-04
Kwelo lizwe leentsomi : iintsomi zesiXhosa
- Authors: Sigcau, Bulelwa Monica
- Date: 2021-04
- Subjects: Creative writing (Higher education) -- South Africa , Xhosa fiction -- 21st century , Diaries -- Authorship , Short stories, Xhosa -- 21st century , African fiction -- History and criticism , English fiction -- History and criticism
- Language: Xhosa
- Type: thesis , text , Masters , MA
- Identifier: http://hdl.handle.net/10962/178270 , vital:42926
- Description: Ukuphosa kuvimba wolwazi ngeentsomi zesiXhosa, le thisisi iqulathe iintsomi-mabali eziqanjwe zabaliswa kusetyenziswa ulwimi, umxholo nemixholo engenelelayo engeziganeko zemihla ngemihla, abalinganiswa, isakhiwo sentsomi nesimo sentlalo zala maxesha siphila kuwo. Ezi ntsomi zixhaswa kakhulu yimifanekiso ephilayo, ukusetyenziswa kwemigca emifutshane ezoba isimo sentlalo nevakala ingathi yimibongo ngenxa yokuqupha kwayo. Umsebenzi kaR.F. Mcimeli, kwincwadi ethi, Ingqaka kaMaqhudeni iqulethe iintsomi ezisondeleyo kwezi ziqanjwe kulo msebenzi, ngakumbi iintsomi ezizezi, uNomvula noNomvulazana, uDumisani nesigebenga esingabonwayo, uNomaciko noCikokazi, nezinye. Umsebenzi kaNongenile Masithathu Zenani (2006) oqokelelwe nguHarold Scheub kwincwadi ethi South African voices: A long time passed ube negaleloo elikhulu ukubonisa indima esele idlaliwe kwiintsomi zesiXhosa. UKholeka Sigenu (2002) kwincwandi ethi Ezakowethu naye ube nefuthe kwindlela ezi ntsomi eziqanjwe ngayo nokuqinisekisa ukuba ngenene zongeza ulwazi olutsha. Ezi ntsomi-mabali zibhentsise okulungileyo nokuhenxayo ngaphandle kokushumayela nokuveza abalinganiswa njengeengilosi. Ndiluthande kakhulu nohlobo lukaAmos Tutuola lokubhala, ndizame ukusondeza uhlobo lwam lokubhala kolu hlobo lukaAmos Tutuola. Ndilandele ifuthe lohlobo lokubhala olubizwa ngeflash fiction. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Sigcau, Bulelwa Monica
- Date: 2021-04
- Subjects: Creative writing (Higher education) -- South Africa , Xhosa fiction -- 21st century , Diaries -- Authorship , Short stories, Xhosa -- 21st century , African fiction -- History and criticism , English fiction -- History and criticism
- Language: Xhosa
- Type: thesis , text , Masters , MA
- Identifier: http://hdl.handle.net/10962/178270 , vital:42926
- Description: Ukuphosa kuvimba wolwazi ngeentsomi zesiXhosa, le thisisi iqulathe iintsomi-mabali eziqanjwe zabaliswa kusetyenziswa ulwimi, umxholo nemixholo engenelelayo engeziganeko zemihla ngemihla, abalinganiswa, isakhiwo sentsomi nesimo sentlalo zala maxesha siphila kuwo. Ezi ntsomi zixhaswa kakhulu yimifanekiso ephilayo, ukusetyenziswa kwemigca emifutshane ezoba isimo sentlalo nevakala ingathi yimibongo ngenxa yokuqupha kwayo. Umsebenzi kaR.F. Mcimeli, kwincwadi ethi, Ingqaka kaMaqhudeni iqulethe iintsomi ezisondeleyo kwezi ziqanjwe kulo msebenzi, ngakumbi iintsomi ezizezi, uNomvula noNomvulazana, uDumisani nesigebenga esingabonwayo, uNomaciko noCikokazi, nezinye. Umsebenzi kaNongenile Masithathu Zenani (2006) oqokelelwe nguHarold Scheub kwincwadi ethi South African voices: A long time passed ube negaleloo elikhulu ukubonisa indima esele idlaliwe kwiintsomi zesiXhosa. UKholeka Sigenu (2002) kwincwandi ethi Ezakowethu naye ube nefuthe kwindlela ezi ntsomi eziqanjwe ngayo nokuqinisekisa ukuba ngenene zongeza ulwazi olutsha. Ezi ntsomi-mabali zibhentsise okulungileyo nokuhenxayo ngaphandle kokushumayela nokuveza abalinganiswa njengeengilosi. Ndiluthande kakhulu nohlobo lukaAmos Tutuola lokubhala, ndizame ukusondeza uhlobo lwam lokubhala kolu hlobo lukaAmos Tutuola. Ndilandele ifuthe lohlobo lokubhala olubizwa ngeflash fiction. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
- Full Text:
- Date Issued: 2021-04
Larval fish dynamics within the coastal nearshore of the Eastern Cape, South Africa
- Authors: Sotshongaye, Oko
- Date: 2021-04
- Subjects: Fishes -- Larvae -- South Africa -- Eastern Cape , Fishes -- Larvae -- Development -- South Africa -- Eastern Cape , Fishes -- Larvae -- Ecology -- South Africa -- Eastern Cape , Coastal ecology -- South Africa -- Eastern Cape , Fishes -- Larvae -- Dispersal -- South Africa -- Eastern Cape
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/176977 , vital:42776
- Description: The coastal nearshore is important for the early development of fishes as it is used for spawning and/or as a nursery. One of the central concerns in coastal ecology is understanding the role of the nearshore for larvae, ultimately providing key knowledge on population dynamics and hence helping in making decisions pertaining to conservation and resource management. The aim of this study was to investigate the alongshore and cross-shore distribution of larval fishes and the links to the physio-chemical conditions (including prevailing winds) and hydrodynamics in the region of Algoa Bay, situated on the south east coast in the warm temperate region of South Africa. Fish larvae were sampled at nine sites for the first component of the study (January 2016 –March 2017) and at four sites for the second component (November 2019), near the surface and bottom (15-50 m) of the water column as well as at two different distances from shore (~400 m/~3 km) using a set of bongo plankton nets towed behind a boat. Environmental data were simultaneously collected using and acoustic Doppler current profiler (ADCP) and conductivity, temperature, depth (CTD) profiler. Larval fish abundance generally decreased with increasing distance from the shore, however, this varied in space and time, with some larval species recorded in high abundances offshore. Close inshore the larvae of coastal fish species producing benthic eggs (CBE) including the Blenniidae and Gobiesocidae mostly dominated, while offshore the larvae of coastal fish species producing pelagic eggs (CPE) i.e. Sparidae and Cynoglossidae, as well as pelagic fish species producing pelagic eggs (PPE) i.e. Clupeidae and Engraulidae mostly dominated. Vertical distribution of larvae differed according to taxon, with the Callionymidae (CPE), Cynoglossidae and Gobiesocidae occurring at high densities at the bottom of the water column, while the Blenniidae dominated near the surface. Fluorescence, temperature and salinity varied with depth (surface/bottom), being particularly high at the surface; currents moved faster at the surface than the bottom of the water column. Increased abundances of larval fishes were evident after upwelling events (associated with easterly winds) in the Bay, while during downwelling (associated with westerly winds), low densities were generally recorded, except for the sites situated near headlands/capes where there were higher densities of fish larvae during downwelling events. Overall, the results of this study suggest that spawning mode of the adults, oceanography and environmental conditions coupled with what is known of the behaviour of fish larvae, were important in shaping the larval fish community of the Algoa Bay region. These results highlight the importance of incorporating multiple biological (developmental stage, reproductive mode, species) and physical (currents, fluorescence, wind-driven up/down-welling) factors when addressing the mechanims of transport of larval fish in the coastal nearshore. , Thesis (MSc) -- Faculty of Science, Department of Zoology and Entomology, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Sotshongaye, Oko
- Date: 2021-04
- Subjects: Fishes -- Larvae -- South Africa -- Eastern Cape , Fishes -- Larvae -- Development -- South Africa -- Eastern Cape , Fishes -- Larvae -- Ecology -- South Africa -- Eastern Cape , Coastal ecology -- South Africa -- Eastern Cape , Fishes -- Larvae -- Dispersal -- South Africa -- Eastern Cape
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/176977 , vital:42776
- Description: The coastal nearshore is important for the early development of fishes as it is used for spawning and/or as a nursery. One of the central concerns in coastal ecology is understanding the role of the nearshore for larvae, ultimately providing key knowledge on population dynamics and hence helping in making decisions pertaining to conservation and resource management. The aim of this study was to investigate the alongshore and cross-shore distribution of larval fishes and the links to the physio-chemical conditions (including prevailing winds) and hydrodynamics in the region of Algoa Bay, situated on the south east coast in the warm temperate region of South Africa. Fish larvae were sampled at nine sites for the first component of the study (January 2016 –March 2017) and at four sites for the second component (November 2019), near the surface and bottom (15-50 m) of the water column as well as at two different distances from shore (~400 m/~3 km) using a set of bongo plankton nets towed behind a boat. Environmental data were simultaneously collected using and acoustic Doppler current profiler (ADCP) and conductivity, temperature, depth (CTD) profiler. Larval fish abundance generally decreased with increasing distance from the shore, however, this varied in space and time, with some larval species recorded in high abundances offshore. Close inshore the larvae of coastal fish species producing benthic eggs (CBE) including the Blenniidae and Gobiesocidae mostly dominated, while offshore the larvae of coastal fish species producing pelagic eggs (CPE) i.e. Sparidae and Cynoglossidae, as well as pelagic fish species producing pelagic eggs (PPE) i.e. Clupeidae and Engraulidae mostly dominated. Vertical distribution of larvae differed according to taxon, with the Callionymidae (CPE), Cynoglossidae and Gobiesocidae occurring at high densities at the bottom of the water column, while the Blenniidae dominated near the surface. Fluorescence, temperature and salinity varied with depth (surface/bottom), being particularly high at the surface; currents moved faster at the surface than the bottom of the water column. Increased abundances of larval fishes were evident after upwelling events (associated with easterly winds) in the Bay, while during downwelling (associated with westerly winds), low densities were generally recorded, except for the sites situated near headlands/capes where there were higher densities of fish larvae during downwelling events. Overall, the results of this study suggest that spawning mode of the adults, oceanography and environmental conditions coupled with what is known of the behaviour of fish larvae, were important in shaping the larval fish community of the Algoa Bay region. These results highlight the importance of incorporating multiple biological (developmental stage, reproductive mode, species) and physical (currents, fluorescence, wind-driven up/down-welling) factors when addressing the mechanims of transport of larval fish in the coastal nearshore. , Thesis (MSc) -- Faculty of Science, Department of Zoology and Entomology, 2021
- Full Text:
- Date Issued: 2021-04