The impact of South Africa's sale of weapons to Saudi Arabia : the case of Yemen
- Authors: Mekuto, Phumelela
- Date: 2024-04
- Subjects: Conflict management , Military weapons , International relations
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63334 , vital:73258
- Description: Since the start of the Yemeni conflict in 2014, both the Saudi-led military and the Iranian-backed Houthi Rebel group have launched missile airstrikes across the nation (Sharp & Brudnick, 2015). These attacks are carried out using high-tech military tools, such as drones, aircraft, bombs, and other weapons. According to Hokayem (2016), nearly 24 million Yemenis require aid as Yemen experiences the world’s largest humanitarian crises. Open Secretes released a report in 2020 outlining that weapons used in the war in Yemen could be traced back to Denel, alluding to its role and complicity in the conflict. The aim of this study is to investigate the role of Denel in the conflict in Yemen and its socio-economic effects. In doing so, South Africa’s trade relations with the Saudi-Arabia will be explored. In addition, unpacking the socio-economic conditions that exists domestically and internationally that influence global arms trade. A qualitative research approach is employed. Secondary research analysis is conducted using government publications, international policy reports, books, journals, and newspaper articles. In addressing the social aspect of the arms trade effects, the humanitarian component uses a psycho-social theoretical framework which encompasses Burtons’ human needs theory. In addition to this main theory, the frustration-aggression theory as well as the relative deprivation theory were applied to support the theory central to the study. Fundamental to this study is understanding Denel’s’ complicity in the conflict in Yemen and the effects thereof. This stems from the company’s trade agreements between itself and Saudi Arabia, which has been at the forefront of multiple proxy wars within the region. Denel’s implied complicity stems from the correlation between the heightened period of conflict in the Yemen and the parastatal’s record-breaking order book during the same period. The research study focuses on the period between 2013 – 2016. Further research has been conducted in order to provide a comprehensive historical account and context of the conflict and the role of Denel as a parastatal organisation. Furthermore, this study delves into ongoing crises and the volatile nature of global arms trade regulations. It is for the reasons alluded to above that the study insists on not limiting period of the study to 2013 – 2016. The study findings suggest that although weapons used in the conflict in Yemen could be traced back to Denel, these were insignificant to the overall contribution to the conflict in Yemen, despite South Africa’s and Saudi Arabia’s breach of the End-User agreement. As a result of Saudi Arabia’s continued infringement of human rights, the state was not to be sold weapons as they are proven to have further ramifications against the protection of human rights. Moreover, the arms trade industry partially functions independently from government intervention and regulation, making it increasingly difficult to implement international policy. What is of paramount importance is the direct effect of conflict on innocent civilians who continue to suffer and the human cost of profit and the struggle for power and resources. Recommendations highlighted in the treatise include striking a balance between profitability and the humanitarian perspective by taking into consideration both private sector profit motives and the public sector's responsibility to prioritise human rights and the well-being of people. This approach ensures efficient management of Denel and reduces the possibility of privatization, as Denel remains the lifeline of the South African Defense Force (SADF). To ensure compliance with domestic and international arms treaty regulations, it is necessary to enforce a stricter process for arms sales justification. The agreement should incorporate legal measures that enable the prosecution of the state in cases where irregularities in weapons sales approval, including corruption or personal/political motives, are identified. The study recommends that Denel should initiate a strategic restructuring plan to revitalise its business model and leadership development. This restructuring should prioritise ethical business practices, legality, and vetting of customer information while ensuring profitability for self-sustainability. Addressing irregular sale agreements is crucial before investing in technology advancement and research. Growth assessment should be based on profit margins and order book prospects to ensure business optimisation and resource adequacy. Denel's success is vital for South Africa's GDP growth. , Thesis (MA) -- Faculty of Humanities, School of Governmental and Social Sciences, 2024
- Full Text:
- Date Issued: 2024-04
- Authors: Mekuto, Phumelela
- Date: 2024-04
- Subjects: Conflict management , Military weapons , International relations
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63334 , vital:73258
- Description: Since the start of the Yemeni conflict in 2014, both the Saudi-led military and the Iranian-backed Houthi Rebel group have launched missile airstrikes across the nation (Sharp & Brudnick, 2015). These attacks are carried out using high-tech military tools, such as drones, aircraft, bombs, and other weapons. According to Hokayem (2016), nearly 24 million Yemenis require aid as Yemen experiences the world’s largest humanitarian crises. Open Secretes released a report in 2020 outlining that weapons used in the war in Yemen could be traced back to Denel, alluding to its role and complicity in the conflict. The aim of this study is to investigate the role of Denel in the conflict in Yemen and its socio-economic effects. In doing so, South Africa’s trade relations with the Saudi-Arabia will be explored. In addition, unpacking the socio-economic conditions that exists domestically and internationally that influence global arms trade. A qualitative research approach is employed. Secondary research analysis is conducted using government publications, international policy reports, books, journals, and newspaper articles. In addressing the social aspect of the arms trade effects, the humanitarian component uses a psycho-social theoretical framework which encompasses Burtons’ human needs theory. In addition to this main theory, the frustration-aggression theory as well as the relative deprivation theory were applied to support the theory central to the study. Fundamental to this study is understanding Denel’s’ complicity in the conflict in Yemen and the effects thereof. This stems from the company’s trade agreements between itself and Saudi Arabia, which has been at the forefront of multiple proxy wars within the region. Denel’s implied complicity stems from the correlation between the heightened period of conflict in the Yemen and the parastatal’s record-breaking order book during the same period. The research study focuses on the period between 2013 – 2016. Further research has been conducted in order to provide a comprehensive historical account and context of the conflict and the role of Denel as a parastatal organisation. Furthermore, this study delves into ongoing crises and the volatile nature of global arms trade regulations. It is for the reasons alluded to above that the study insists on not limiting period of the study to 2013 – 2016. The study findings suggest that although weapons used in the conflict in Yemen could be traced back to Denel, these were insignificant to the overall contribution to the conflict in Yemen, despite South Africa’s and Saudi Arabia’s breach of the End-User agreement. As a result of Saudi Arabia’s continued infringement of human rights, the state was not to be sold weapons as they are proven to have further ramifications against the protection of human rights. Moreover, the arms trade industry partially functions independently from government intervention and regulation, making it increasingly difficult to implement international policy. What is of paramount importance is the direct effect of conflict on innocent civilians who continue to suffer and the human cost of profit and the struggle for power and resources. Recommendations highlighted in the treatise include striking a balance between profitability and the humanitarian perspective by taking into consideration both private sector profit motives and the public sector's responsibility to prioritise human rights and the well-being of people. This approach ensures efficient management of Denel and reduces the possibility of privatization, as Denel remains the lifeline of the South African Defense Force (SADF). To ensure compliance with domestic and international arms treaty regulations, it is necessary to enforce a stricter process for arms sales justification. The agreement should incorporate legal measures that enable the prosecution of the state in cases where irregularities in weapons sales approval, including corruption or personal/political motives, are identified. The study recommends that Denel should initiate a strategic restructuring plan to revitalise its business model and leadership development. This restructuring should prioritise ethical business practices, legality, and vetting of customer information while ensuring profitability for self-sustainability. Addressing irregular sale agreements is crucial before investing in technology advancement and research. Growth assessment should be based on profit margins and order book prospects to ensure business optimisation and resource adequacy. Denel's success is vital for South Africa's GDP growth. , Thesis (MA) -- Faculty of Humanities, School of Governmental and Social Sciences, 2024
- Full Text:
- Date Issued: 2024-04
The role of hashtag activism in advocating against gender-based violence and promoting perpetrator accountability : subtitle if needed. If no subtitle follow instructions in manual
- Authors: Nontyi, Antonnet
- Date: 2024-04
- Subjects: Gender based violence , Victims of violent crimes , Women -- Crimes against -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63421 , vital:73356
- Description: This study is aimed at determining the role that hashtag activism has played in advocating against gender-based violence (GBV) and promoting perpetrator accountability. The study used major GBV hashtags such as #MeToo, #WhyIStayed and #AmINext to investigate how effective these hashtag movements have been in breaking the silence around GBV and fighting against GBV. The study made use of both qualitative and quantitative research methodology, which was useful to gain a deeper understanding of GBV and all the social and cultural practices that perpetuate it. Qualitative data were collected by means of interviews and tweets under the selected hashtags. An online survey questionnaire was used to collect quantitative data. The data provided an understanding of the complexities surrounding GBV and people’s views on hashtag activism and GBV. Through the data analysis, the study found that hashtag activism has been effective in changing dominant discourses, advocating against GBV, creating awareness and solidarity around GBV issues, and promoting perpetrator accountability. The study calls for a global collective effort to develop, record and archive feminist initiatives so that all the structural conditions which enable and perpetuate sexual violence are exposed and cannot be forgotten or ignored. Future research should look into how harmful societal norms can be challenged and how the effectiveness of hashtag movements can be enhanced , Thesis (MA) -- Faculty of Humanities, School of Language, Media and Communication, 2024
- Full Text:
- Date Issued: 2024-04
- Authors: Nontyi, Antonnet
- Date: 2024-04
- Subjects: Gender based violence , Victims of violent crimes , Women -- Crimes against -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63421 , vital:73356
- Description: This study is aimed at determining the role that hashtag activism has played in advocating against gender-based violence (GBV) and promoting perpetrator accountability. The study used major GBV hashtags such as #MeToo, #WhyIStayed and #AmINext to investigate how effective these hashtag movements have been in breaking the silence around GBV and fighting against GBV. The study made use of both qualitative and quantitative research methodology, which was useful to gain a deeper understanding of GBV and all the social and cultural practices that perpetuate it. Qualitative data were collected by means of interviews and tweets under the selected hashtags. An online survey questionnaire was used to collect quantitative data. The data provided an understanding of the complexities surrounding GBV and people’s views on hashtag activism and GBV. Through the data analysis, the study found that hashtag activism has been effective in changing dominant discourses, advocating against GBV, creating awareness and solidarity around GBV issues, and promoting perpetrator accountability. The study calls for a global collective effort to develop, record and archive feminist initiatives so that all the structural conditions which enable and perpetuate sexual violence are exposed and cannot be forgotten or ignored. Future research should look into how harmful societal norms can be challenged and how the effectiveness of hashtag movements can be enhanced , Thesis (MA) -- Faculty of Humanities, School of Language, Media and Communication, 2024
- Full Text:
- Date Issued: 2024-04
The role of popular and traditional music during the umgidi initiation ceremonies among the Amampondo: subtitle if needed. If no subtitle follow instructions in manual
- Authors: Gushu, Lindokuhle
- Date: 2024-04
- Subjects: Xhosa (African people) -- Music , Folk music -- Social aspects -- South Africa -- Eastern Cape , Xhosa (African people) -- Rites and ceremonies , Popular music -- South Africa -- Eastern Cape
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62805 , vital:72962
- Description: This study investigates the intricate dynamics of music within the umgidi initiation ceremonies among the amaMpondo, focusing on the interplay between traditional and modern popular music. The study explores the cultural foundation of the umgidi ceremony, emphasising its transformative significance and the evolving influence of modern popular music, particularly among the youth. A comprehensive literature review follows, contextualising the amaMpondo, their cultural practices, and the complex relationship between traditional and popular music in the broader South African music scene. The study adopted a qualitative ethnographic approach, including participant observation and individual interviews, to explore the impact of modern popular music on traditional elements during umgidi initiation ceremonies. Thematic analysis was employed for data interpretation, ensuring a systematic exploration of patterns and meanings. Ethical considerations were meticulously addressed, emphasising protecting participants' rights and cultural sensitivity. The study's findings highlighted the multifaceted roles of music during umgidi initiation ceremonies. Music is a powerful medium for cultural expression, communication, and communal celebration. The call-and-response format, rhythm variations, and the influence of modern genres such as Gqom and Amapiano were explored. Community attitudes toward integrating modern popular music reveal diverse opinions, ranging from full embrace to resistance. In summary, this study contributes to understanding the evolving dynamics of music in umgidi initiation ceremonies among the amaMpondo. The study provides a nuanced exploration and a roadmap for future research, community engagement, and policy considerations by combining cultural insights, literature review, methodological rigour, and community perspectives. , Thesis (MMus) -- Faculty of Humanities, School of Visual and Performing Arts, 2023
- Full Text:
- Date Issued: 2024-04
- Authors: Gushu, Lindokuhle
- Date: 2024-04
- Subjects: Xhosa (African people) -- Music , Folk music -- Social aspects -- South Africa -- Eastern Cape , Xhosa (African people) -- Rites and ceremonies , Popular music -- South Africa -- Eastern Cape
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62805 , vital:72962
- Description: This study investigates the intricate dynamics of music within the umgidi initiation ceremonies among the amaMpondo, focusing on the interplay between traditional and modern popular music. The study explores the cultural foundation of the umgidi ceremony, emphasising its transformative significance and the evolving influence of modern popular music, particularly among the youth. A comprehensive literature review follows, contextualising the amaMpondo, their cultural practices, and the complex relationship between traditional and popular music in the broader South African music scene. The study adopted a qualitative ethnographic approach, including participant observation and individual interviews, to explore the impact of modern popular music on traditional elements during umgidi initiation ceremonies. Thematic analysis was employed for data interpretation, ensuring a systematic exploration of patterns and meanings. Ethical considerations were meticulously addressed, emphasising protecting participants' rights and cultural sensitivity. The study's findings highlighted the multifaceted roles of music during umgidi initiation ceremonies. Music is a powerful medium for cultural expression, communication, and communal celebration. The call-and-response format, rhythm variations, and the influence of modern genres such as Gqom and Amapiano were explored. Community attitudes toward integrating modern popular music reveal diverse opinions, ranging from full embrace to resistance. In summary, this study contributes to understanding the evolving dynamics of music in umgidi initiation ceremonies among the amaMpondo. The study provides a nuanced exploration and a roadmap for future research, community engagement, and policy considerations by combining cultural insights, literature review, methodological rigour, and community perspectives. , Thesis (MMus) -- Faculty of Humanities, School of Visual and Performing Arts, 2023
- Full Text:
- Date Issued: 2024-04
Tienerafrikaans: ’n studie van tienertaal, met spesiale verwysing na sleng, in twee Inxuba Yethemba (RSA-)skole
- Authors: Holland, Anil Juan
- Date: 2024-04
- Subjects: Afrikaans language -- Social aspects -- South Africa -- Eastern Cape , Afrikaanse taal -- Grammatika , Code switching (Linguistics)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62816 , vital:72980
- Description: It is understood that, for us humans to communicate with one another, we need language. Communication thus has a close relationship with society. But language changes and it has many varieties. On the one hand we have the standard variety of a language which is mostly used in formal situations, and on the other hand we have other varieties, which are mostly used in informal situations. Slang serves as an example of the latter and is chiefly used by adolescents – individuals between the ages of 13 and 19. As Saal and Lawrence (2019: 24) put it: young people are the agents of linguistic change. The researcher finds the language of teenagers quite interesting seeing that he is a teacher who frequently comes across words or phrases he has not heard or does not know the meaning of. The goal of this study is thus to investigate teenage language as phenomenon, with special reference to slang. This study examines slang words and expressions as they occur among teenagers in two Nxuba (formerly Cradock) schools, as well as find out why, when, and when the research group will not make use of slang. Nxuba forms part of the Inxuba Yethemba Municipality in the Eastern Cape. During the study general linguistic phenomena that occur among the teenagers in the given town are also investigated. These phenomena are analysed using the phonetic, phonological, morphological, syntactic, semantic, and lexical levels of variation. This study follows a qualitative approach with the help of questionnaires, direct observation, and focus group interviews as data collection methods. It was found that teenagers are highly creative and create novel words or give new meanings to words that already exist in the standard variety. The reasons why teenagers make use of slang is, among other things, to ease communication, for the fun of it, secrecy, and to enrich the standard variety. Slang is mostly used in informal situations and tends to be avoided in the presence of older persons, at church, and when doing schoolwork. There are also various linguistic phenomena that appear in teenagers’ general language usage: borrowing, reduction, homonyms, polysemes, and various phonological phenomena, among other. , Thesis (MA) -- Faculty of Humanities , School of Language, Media and Communication , 2024
- Full Text:
- Date Issued: 2024-04
- Authors: Holland, Anil Juan
- Date: 2024-04
- Subjects: Afrikaans language -- Social aspects -- South Africa -- Eastern Cape , Afrikaanse taal -- Grammatika , Code switching (Linguistics)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62816 , vital:72980
- Description: It is understood that, for us humans to communicate with one another, we need language. Communication thus has a close relationship with society. But language changes and it has many varieties. On the one hand we have the standard variety of a language which is mostly used in formal situations, and on the other hand we have other varieties, which are mostly used in informal situations. Slang serves as an example of the latter and is chiefly used by adolescents – individuals between the ages of 13 and 19. As Saal and Lawrence (2019: 24) put it: young people are the agents of linguistic change. The researcher finds the language of teenagers quite interesting seeing that he is a teacher who frequently comes across words or phrases he has not heard or does not know the meaning of. The goal of this study is thus to investigate teenage language as phenomenon, with special reference to slang. This study examines slang words and expressions as they occur among teenagers in two Nxuba (formerly Cradock) schools, as well as find out why, when, and when the research group will not make use of slang. Nxuba forms part of the Inxuba Yethemba Municipality in the Eastern Cape. During the study general linguistic phenomena that occur among the teenagers in the given town are also investigated. These phenomena are analysed using the phonetic, phonological, morphological, syntactic, semantic, and lexical levels of variation. This study follows a qualitative approach with the help of questionnaires, direct observation, and focus group interviews as data collection methods. It was found that teenagers are highly creative and create novel words or give new meanings to words that already exist in the standard variety. The reasons why teenagers make use of slang is, among other things, to ease communication, for the fun of it, secrecy, and to enrich the standard variety. Slang is mostly used in informal situations and tends to be avoided in the presence of older persons, at church, and when doing schoolwork. There are also various linguistic phenomena that appear in teenagers’ general language usage: borrowing, reduction, homonyms, polysemes, and various phonological phenomena, among other. , Thesis (MA) -- Faculty of Humanities , School of Language, Media and Communication , 2024
- Full Text:
- Date Issued: 2024-04
Translanguaging as pedagogical practice in high-school examination question papers: a South African case study
- Authors: Matikinca, Uviwe
- Date: 2024-04
- Subjects: Sociolinguistics -- Research , Structural linguistics -- Research , Applied linguistics
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63248 , vital:73241
- Description: This study explores sociolinguistic practices such as translanguaging, in which “diglossia is presumably allowed without isolation and bilinguals’ linguistic resources are viewed as an integrated system.” While bilinguals select and deploy particular features from their linguistic repertoires for meaning-making, translanguaging is widely used by teachers and students in multilingual classroom settings, as guided by the Personnel Administrative Measures (PAM). Translanguaging also provides a path for students to bring in and use their linguistic repertoires to produce the required learning outcomes, perform their identities and facilitate language development. Thus, this study is based on the view, subscribed to in contemporary sociolinguistics, that monoglossic language ideology is embedded in modes of oppression steeped in neoliberal, colonial and linguistic purist forms”. The purpose of the study was to make a case for the implementation of translanguaging in the written assessment of isiXhosa/English bilingual high-school learners in the Eastern Cape. The study employed a qualitative approach in the form of document analysis, whereby the researcher used selected Grade 12 question papers to find out how often translanguaging occurred. This was done by illustrating how examiners are moving past forms of linguistic purism when setting papers. , Thesis (MA) -- Faculty of Humanities, School of Language, Media and Communication, 2024
- Full Text:
- Date Issued: 2024-04
- Authors: Matikinca, Uviwe
- Date: 2024-04
- Subjects: Sociolinguistics -- Research , Structural linguistics -- Research , Applied linguistics
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63248 , vital:73241
- Description: This study explores sociolinguistic practices such as translanguaging, in which “diglossia is presumably allowed without isolation and bilinguals’ linguistic resources are viewed as an integrated system.” While bilinguals select and deploy particular features from their linguistic repertoires for meaning-making, translanguaging is widely used by teachers and students in multilingual classroom settings, as guided by the Personnel Administrative Measures (PAM). Translanguaging also provides a path for students to bring in and use their linguistic repertoires to produce the required learning outcomes, perform their identities and facilitate language development. Thus, this study is based on the view, subscribed to in contemporary sociolinguistics, that monoglossic language ideology is embedded in modes of oppression steeped in neoliberal, colonial and linguistic purist forms”. The purpose of the study was to make a case for the implementation of translanguaging in the written assessment of isiXhosa/English bilingual high-school learners in the Eastern Cape. The study employed a qualitative approach in the form of document analysis, whereby the researcher used selected Grade 12 question papers to find out how often translanguaging occurred. This was done by illustrating how examiners are moving past forms of linguistic purism when setting papers. , Thesis (MA) -- Faculty of Humanities, School of Language, Media and Communication, 2024
- Full Text:
- Date Issued: 2024-04
Ukuphononongwa kokushiywa nokubuyelwa ziinkumbulo kwababhali abachongiweyo kwiincwadi zeothobhayografi KaMtuze nomagona
- Authors: Stemela, Nozuko Precious
- Date: 2024-04
- Subjects: Mtuze, Peter Tshobiso , Xhosa literature -- History and criticism , Authors, Xhosa -- Biography
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63529 , vital:73385
- Description: Olu phando lugxile ekuphononongeni ukukhumbula nokulibala kwii-othobhayografi ezibhaliweyo ekaMagona (1995) noMtuze (1976). Ii-othobhayografi eziza kusetyenziswa luphando zithi: Indlel’ Ebhek’ Enkundleni ngokukaPeter Mtuze (1976) nethi, Kubantwana Babantwana Bam ngokukaSindiwe Magona (1995). Xa kusenziwa uphando kuza kuhlalutywa amanqanaba okukhumbula nokulibala ukusukela ebuntwaneni ukuya kutsho ebudaleni kubabhali bee-othobhayografi. Uhlalutyo luza kube lugxininise ekujongeni iinkumbulo zababhali, luhamba nabo ngokwamanqanaba okukhula kwabo, amanqanaba okukhumbula nokulibala njengoko bekhula. Uphando luza kungqiyama ngengcingane yokukhumbula nokulibala eyasungulwa nguEbbinghaus (1885) kuphando lwakhe awayelwenza. Iinjongo zikaEbbinghaus ongumsunguli wengcingane zokuzisa ulwazi ngengcingane yokukhumbula nokulibala kukubonisa indlela ukulibala okwenzeka ngayo. UEbbinghaus uye wasebenzisa ikhevu yokulibala ukuvelisa banzi ingcingane. Lo msunguli wale ngcingane yokukhumbula nokulibala uthi, le khevu yokulibala ibonisa ukwehla kwezinga lokukhumbula okanye iqondo lokukhumbula xa luthe ulwazi lwalahleka ngenxa yokungenziwa kwamatiletile okulugcina nokukhunjulwa ngumninilo. Oku uEbbinghaus (1885) ukucacisa kwincwadi yakhe ethi Memory (1850-1909). Uphando njengokuba lubandakanya okwenzeka kwingqondo luza kube lukhatshwa yingcingane yokuqonda. Ingcingane yokuqonda yingcingane enkulu nengcingane ethe yajongwa kakhulu ziingcali ezininzi, ikwaphuhliswa ziingcaphephe ezininzi nezifundiswa. Uphando lukhethe ukuvelisa uEbbinghaus ukubonisa ingcingane yokukhumbula nokulibala, kodwa yona iphefumlelwe ziingcaphephe ezininzi mandulo. NgokukaGuyer (1998:1) enye yeengcaphephe abhale ngayo ethetha ngengcingane yokukhumbula nokuqonda nguKant (1724-1804) owaziwa ngomsebenzi wakhe othi: The Critique of Pure Reason. Lo msebenzi ucatshulwe apha kulapho uKant (1724-1804) athetha ngendlela yokuqonda ulwazi nokuzisa izizathu. Emva koko iingcali ezininzi ziye zaqhuba nengcingane yokuqonda ukuza kuthi ga kule mihla. Oku kuquka ingcali uChart (2017) obhale ngengcinane yokuqonda ngokwale mihla. Uphando luza kuvelisa ingcingane yesini njengengcingane ekhaphayo. Ingcingane yesini iza kusetyenziselwa ukuthelekiswa kwababhali bee-othobhayografi kujongwa indlela yokukhumbula nokulibala kugudlwe isini. Ngonyaka we-1955 uMoney (1955) waye wapapasha iphepha kunye nabo asebenza nabo kwiSebe lezeNgqondo uJoan G. Hampson nomyeni wakhe uJohn L. Hampson apho babeqala ukwazisa ngenkquleqhu yendima yesini besithi: Zonke izinto azithethayo okanye azenzayo umntu ukuze azichaze njengenkwenkwe okanye indoda, intombazana okanye ibhinqa, ngokulandelelanayo, zibizwa ngokuba ziindima zesini. Kulapho uMoney (1955) wathi wasungula khona le ngcingane yesini eza kuthi ithathe inxaxheba kolu phando ngokubonisa ukukhumbula nokulibala kwisini. Olu phando luza kuthi lwenziwe ngohlobo olubizwa ngokuba yintyilazwi. Intyilazwi ilunge kakhulu kolu hlobo lophando kuba luphando olufundisayo njengokuba luvelisa unobangela wokukhumbula nezizathu zokulibala. Intyilazwi iyagqitha ize ijonge amava ababhali, indlela abazicacise ngayo iinkumbulo zabo nendlela abazibhale ngayo iiothobhayografi zabo bechaza iziganeko zokukhula kwabo. Olu hlobo luza kube lungajongi zigrafu okanye manani kodwa lujonga kakhulu indlela yokuhlalutya oko kubhaliweyo. Iincwadi ezisetyenziswa kuphando ziza kushwankathelwa zibuye zihlalutywe ngokwendlela yokuhlola iziganeko zokukhumbula nokulibala kwababhali. , Thesis (MA) -- Faculty of Humanities, School of Langauge, Media and Communication, 2024
- Full Text:
- Date Issued: 2024-04
- Authors: Stemela, Nozuko Precious
- Date: 2024-04
- Subjects: Mtuze, Peter Tshobiso , Xhosa literature -- History and criticism , Authors, Xhosa -- Biography
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63529 , vital:73385
- Description: Olu phando lugxile ekuphononongeni ukukhumbula nokulibala kwii-othobhayografi ezibhaliweyo ekaMagona (1995) noMtuze (1976). Ii-othobhayografi eziza kusetyenziswa luphando zithi: Indlel’ Ebhek’ Enkundleni ngokukaPeter Mtuze (1976) nethi, Kubantwana Babantwana Bam ngokukaSindiwe Magona (1995). Xa kusenziwa uphando kuza kuhlalutywa amanqanaba okukhumbula nokulibala ukusukela ebuntwaneni ukuya kutsho ebudaleni kubabhali bee-othobhayografi. Uhlalutyo luza kube lugxininise ekujongeni iinkumbulo zababhali, luhamba nabo ngokwamanqanaba okukhula kwabo, amanqanaba okukhumbula nokulibala njengoko bekhula. Uphando luza kungqiyama ngengcingane yokukhumbula nokulibala eyasungulwa nguEbbinghaus (1885) kuphando lwakhe awayelwenza. Iinjongo zikaEbbinghaus ongumsunguli wengcingane zokuzisa ulwazi ngengcingane yokukhumbula nokulibala kukubonisa indlela ukulibala okwenzeka ngayo. UEbbinghaus uye wasebenzisa ikhevu yokulibala ukuvelisa banzi ingcingane. Lo msunguli wale ngcingane yokukhumbula nokulibala uthi, le khevu yokulibala ibonisa ukwehla kwezinga lokukhumbula okanye iqondo lokukhumbula xa luthe ulwazi lwalahleka ngenxa yokungenziwa kwamatiletile okulugcina nokukhunjulwa ngumninilo. Oku uEbbinghaus (1885) ukucacisa kwincwadi yakhe ethi Memory (1850-1909). Uphando njengokuba lubandakanya okwenzeka kwingqondo luza kube lukhatshwa yingcingane yokuqonda. Ingcingane yokuqonda yingcingane enkulu nengcingane ethe yajongwa kakhulu ziingcali ezininzi, ikwaphuhliswa ziingcaphephe ezininzi nezifundiswa. Uphando lukhethe ukuvelisa uEbbinghaus ukubonisa ingcingane yokukhumbula nokulibala, kodwa yona iphefumlelwe ziingcaphephe ezininzi mandulo. NgokukaGuyer (1998:1) enye yeengcaphephe abhale ngayo ethetha ngengcingane yokukhumbula nokuqonda nguKant (1724-1804) owaziwa ngomsebenzi wakhe othi: The Critique of Pure Reason. Lo msebenzi ucatshulwe apha kulapho uKant (1724-1804) athetha ngendlela yokuqonda ulwazi nokuzisa izizathu. Emva koko iingcali ezininzi ziye zaqhuba nengcingane yokuqonda ukuza kuthi ga kule mihla. Oku kuquka ingcali uChart (2017) obhale ngengcinane yokuqonda ngokwale mihla. Uphando luza kuvelisa ingcingane yesini njengengcingane ekhaphayo. Ingcingane yesini iza kusetyenziselwa ukuthelekiswa kwababhali bee-othobhayografi kujongwa indlela yokukhumbula nokulibala kugudlwe isini. Ngonyaka we-1955 uMoney (1955) waye wapapasha iphepha kunye nabo asebenza nabo kwiSebe lezeNgqondo uJoan G. Hampson nomyeni wakhe uJohn L. Hampson apho babeqala ukwazisa ngenkquleqhu yendima yesini besithi: Zonke izinto azithethayo okanye azenzayo umntu ukuze azichaze njengenkwenkwe okanye indoda, intombazana okanye ibhinqa, ngokulandelelanayo, zibizwa ngokuba ziindima zesini. Kulapho uMoney (1955) wathi wasungula khona le ngcingane yesini eza kuthi ithathe inxaxheba kolu phando ngokubonisa ukukhumbula nokulibala kwisini. Olu phando luza kuthi lwenziwe ngohlobo olubizwa ngokuba yintyilazwi. Intyilazwi ilunge kakhulu kolu hlobo lophando kuba luphando olufundisayo njengokuba luvelisa unobangela wokukhumbula nezizathu zokulibala. Intyilazwi iyagqitha ize ijonge amava ababhali, indlela abazicacise ngayo iinkumbulo zabo nendlela abazibhale ngayo iiothobhayografi zabo bechaza iziganeko zokukhula kwabo. Olu hlobo luza kube lungajongi zigrafu okanye manani kodwa lujonga kakhulu indlela yokuhlalutya oko kubhaliweyo. Iincwadi ezisetyenziswa kuphando ziza kushwankathelwa zibuye zihlalutywe ngokwendlela yokuhlola iziganeko zokukhumbula nokulibala kwababhali. , Thesis (MA) -- Faculty of Humanities, School of Langauge, Media and Communication, 2024
- Full Text:
- Date Issued: 2024-04
Uphando ngenxaxheba yemithombo yosasazo ekwakheni nasekuqambeni isigama esitsha: lugxile kunomathotholo, uMhlobo Wenene kwinkqubo iBreakfast eyondlayo ekuseni
- Authors: Ntlantsana, Likona
- Date: 2024-04
- Subjects: Sociolinguistics -- South Africa -- Eastern Cape , Language and languages—Phonetic transcriptions , Xhosa language--Grammar
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63451 , vital:73367
- Description: Olu phando luhlola amandla emithombo yosasazo ekwakheni nasekuqambeni isigama. Lukwenze oku ngokuphanda ngendlela abantu abawabona ngayo amagama amatsha esiXhosa aveliswe kunomathotholo, Umhlobo Wenene kwinkqubo iBreakfast Eyondlayo Ekuseni. Esi sifundo sikhangela ukwamkeleka kwala magama kuluntu. Oku kwenziwe ngokuthi kwenziwe udliwanondlebe lobuso ngobuso leqela elingqalileyo oluthe ngqo nabasasazi kunye nabaphulaphuli.Uphando lungqiyame lwaqamela ngendlela yophando edibanisa uphando olujolise kumanani nobalo kunye nophando olujolise kwinkcazo nakubunjani. Olu phando lwenziwe kwiidolophu ezimbini, iTsomo neGqeberha. Zombini ezi dolophu zikwiphondo leMpuma Koloni, eMzantsi Afrika apho abahlali abaninzi bathetha isiXhosa. ITsomo yidolophu esemaphandleni enezinga eliphantsi labantu abathetha ezinye iilwimi ngaphandle kwesiXhosa. Ngoko ke isiXhosa lolona lwimi lutshilayo eTsomo. EGqeberha kulapho Umhlobo Wenene ukhoyo. Ukusebenzisa abantu abasuka kwiindawo ezahlukeneyo kuveza iimbono ezahlukileyo ezithe zanceda ukuphendula iinjongo zolu phando. Injongo yolu phando kukukhangela inxaxheba yonomathotholo, Umhlobo Wenene ekukhuliseni ulwimi lwesiXhosa lugxile kwinkqubo iBreakfast Eyondlayo Ekuseni (BEE). Uphando luza kujolisa kumagama aveliswe kunomathotholo, Umhlobo Wenene kwinkqubo iBreakfast Eyondlayo Ekuseni. Iziphumo zophando kufikelelwe kuzo ngokuthi kuthelekiswe iimpendulo zabo kuvele isisombululo sengxaki yophando kuzo. Oku kuthe kwanceda ukuphendula umbuzo wophando ofuna ukuqonda ukuba ingaba unomthotholo, Umhlobo Wenene kwinkqubo iBreakfast Eyondlayo Ekuseni udlala inxaxheba ekhukhuliseni ulwimi lwesiXhosa? Kuyabonakala okokuba ngokwendlela asetyenziswa ngayo amagama aveliswe ngabasasazi kwinkqubo iBreakfast Eyondlayo Ekuseni abaphulaphuli bayawuvuyela kwaye bawaphindisela kubasasazi. , Thesis (MA) -- Faculty of Humanities, School of Language, Media and Communication, 2024
- Full Text:
- Date Issued: 2024-04
- Authors: Ntlantsana, Likona
- Date: 2024-04
- Subjects: Sociolinguistics -- South Africa -- Eastern Cape , Language and languages—Phonetic transcriptions , Xhosa language--Grammar
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63451 , vital:73367
- Description: Olu phando luhlola amandla emithombo yosasazo ekwakheni nasekuqambeni isigama. Lukwenze oku ngokuphanda ngendlela abantu abawabona ngayo amagama amatsha esiXhosa aveliswe kunomathotholo, Umhlobo Wenene kwinkqubo iBreakfast Eyondlayo Ekuseni. Esi sifundo sikhangela ukwamkeleka kwala magama kuluntu. Oku kwenziwe ngokuthi kwenziwe udliwanondlebe lobuso ngobuso leqela elingqalileyo oluthe ngqo nabasasazi kunye nabaphulaphuli.Uphando lungqiyame lwaqamela ngendlela yophando edibanisa uphando olujolise kumanani nobalo kunye nophando olujolise kwinkcazo nakubunjani. Olu phando lwenziwe kwiidolophu ezimbini, iTsomo neGqeberha. Zombini ezi dolophu zikwiphondo leMpuma Koloni, eMzantsi Afrika apho abahlali abaninzi bathetha isiXhosa. ITsomo yidolophu esemaphandleni enezinga eliphantsi labantu abathetha ezinye iilwimi ngaphandle kwesiXhosa. Ngoko ke isiXhosa lolona lwimi lutshilayo eTsomo. EGqeberha kulapho Umhlobo Wenene ukhoyo. Ukusebenzisa abantu abasuka kwiindawo ezahlukeneyo kuveza iimbono ezahlukileyo ezithe zanceda ukuphendula iinjongo zolu phando. Injongo yolu phando kukukhangela inxaxheba yonomathotholo, Umhlobo Wenene ekukhuliseni ulwimi lwesiXhosa lugxile kwinkqubo iBreakfast Eyondlayo Ekuseni (BEE). Uphando luza kujolisa kumagama aveliswe kunomathotholo, Umhlobo Wenene kwinkqubo iBreakfast Eyondlayo Ekuseni. Iziphumo zophando kufikelelwe kuzo ngokuthi kuthelekiswe iimpendulo zabo kuvele isisombululo sengxaki yophando kuzo. Oku kuthe kwanceda ukuphendula umbuzo wophando ofuna ukuqonda ukuba ingaba unomthotholo, Umhlobo Wenene kwinkqubo iBreakfast Eyondlayo Ekuseni udlala inxaxheba ekhukhuliseni ulwimi lwesiXhosa? Kuyabonakala okokuba ngokwendlela asetyenziswa ngayo amagama aveliswe ngabasasazi kwinkqubo iBreakfast Eyondlayo Ekuseni abaphulaphuli bayawuvuyela kwaye bawaphindisela kubasasazi. , Thesis (MA) -- Faculty of Humanities, School of Language, Media and Communication, 2024
- Full Text:
- Date Issued: 2024-04
'N polisistemiese ondersoek na die poësie van instagram-digters
- Authors: De Wat Jane
- Date: 2023-12
- Subjects: Prosodic analysis (Linguistics) , Poetry
- Language: Afrikaans
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63265 , vital:73242
- Description: Die doel van hierdie studie is om die opkoms van Afrikaanse Instagrampoësie en die literêre en sosiale status daarvan te ondersoek met spesifieke verwysing na die volgende Afrikaanse aanlyn digters en hul selfpublikasies: Skakerings van geel (@skildermetdigkuns) en Alles wat ek wou sê (@ontmasker), sowel as die sogenaamde Rupi Kaur van Afrikaanse Instagrampoësie, (@kaalwoorde), se digbundel Kosmos en komete wat onlangs deur LAPA Uitgewers gepubliseer is. Daar word ondersoek ingestel na die manier waarop die metamodernistiese konteks waarbinne digitale of e-letterkunde ontwikkel het, in dié skryfstyl manifesteer. In my ondersoek fokus ek op metamodernisme eerder as postmodernisme, omdat metamodernisme groter klem op die waarheid en die objektiewe realiteit plaas, wat ʼn opvallende tema in die werk van die gekose digters is. Die impak van aanlyn poësie op die identiteit en voorstelling van die Zoomer-generasie (individue wat ná 1996 gebore is, andersins bekend as generasie Z) word nagespeur ten einde die impak van hierdie poësie op die gemiddelde Afrikaanse Zoomer-leser te bepaal. Verskeie vrae rakende die posisie van Instagrampoësie binne die Afrikaanse literêre diskoers en kanon word ook onder die loep geneem. Die analise en interpretasie van die gedigte is daarop gemik om die literêre status van hierdie gedigte te ondersoek op grond van skryfpatrone, die evolusie daarvan en die gewildheid wat gemeet word in terme van followers (voortaan volgelinge), likes (voortaan bekend as voorkeure) en comments (voortaan kommentaar).1 Daar is bewys dat die metamodernistiese konteks (wat breedvoerig in die studie gekonseptualiseer en in terme van Suid-Afrika gekontekstualiseer word) waarin hierdie gedigte geformuleer en versprei is, ʼn beduidende invloed het op die toon en temas daarvan. Daar word getoon dat die tematiese stryd met kwessies soos identiteit, geloof en liefde in dié woordkuns verband hou met die sosiopolitieke konteks van die Zoomer-generasie. Hierdie metamodernistiese toestand word gekenmerk deur progressiewe denke, diversiteit en ʼn samelewing wat voortdurend verander. Die gevolgtrekking word gemaak dat Afrikaanse Instagrampoësie ʼn literêre diskoers skep met die doel om nuwe idees met betrekking tot die waarhede van ʼn generasie wat dikwels misverstaan en misgekyk word, voor te stel. Die vryheid van Instagrampoësie bied met ander woorde ʼn geleentheid vir Zoomer-denkers om hulle stempel binne ʼn metamoderne samelewing af te druk. Deur Even-Zohar se 1 Instagram-terme wat verwys na die hoeveelheid mense wat die digter volg, sy/haar/sig gedigte lees en dan ook daarop reageer op ʼn “hou van/hou nie van nie” glyskaal. 4 polisisteemteorie en die leser-reaksie-teorie by die ondersoek na die skep en ontvangs van aanlyn poësie te betrek, word aangetoon dat e-letterkunde wel ʼn plek binne die Afrikaanse literêre diskoers vind. Hoewel die skeppingsproses, publikasie en ontvangs van aanlyn poësie verskil van dié van ander literêre vorme, stel die studie hierdie vorm van poësie aan die Afrikaanse literêre diskoers en kanon bekend. , Thesis (MA) -- Faculty of Humanities, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: De Wat Jane
- Date: 2023-12
- Subjects: Prosodic analysis (Linguistics) , Poetry
- Language: Afrikaans
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63265 , vital:73242
- Description: Die doel van hierdie studie is om die opkoms van Afrikaanse Instagrampoësie en die literêre en sosiale status daarvan te ondersoek met spesifieke verwysing na die volgende Afrikaanse aanlyn digters en hul selfpublikasies: Skakerings van geel (@skildermetdigkuns) en Alles wat ek wou sê (@ontmasker), sowel as die sogenaamde Rupi Kaur van Afrikaanse Instagrampoësie, (@kaalwoorde), se digbundel Kosmos en komete wat onlangs deur LAPA Uitgewers gepubliseer is. Daar word ondersoek ingestel na die manier waarop die metamodernistiese konteks waarbinne digitale of e-letterkunde ontwikkel het, in dié skryfstyl manifesteer. In my ondersoek fokus ek op metamodernisme eerder as postmodernisme, omdat metamodernisme groter klem op die waarheid en die objektiewe realiteit plaas, wat ʼn opvallende tema in die werk van die gekose digters is. Die impak van aanlyn poësie op die identiteit en voorstelling van die Zoomer-generasie (individue wat ná 1996 gebore is, andersins bekend as generasie Z) word nagespeur ten einde die impak van hierdie poësie op die gemiddelde Afrikaanse Zoomer-leser te bepaal. Verskeie vrae rakende die posisie van Instagrampoësie binne die Afrikaanse literêre diskoers en kanon word ook onder die loep geneem. Die analise en interpretasie van die gedigte is daarop gemik om die literêre status van hierdie gedigte te ondersoek op grond van skryfpatrone, die evolusie daarvan en die gewildheid wat gemeet word in terme van followers (voortaan volgelinge), likes (voortaan bekend as voorkeure) en comments (voortaan kommentaar).1 Daar is bewys dat die metamodernistiese konteks (wat breedvoerig in die studie gekonseptualiseer en in terme van Suid-Afrika gekontekstualiseer word) waarin hierdie gedigte geformuleer en versprei is, ʼn beduidende invloed het op die toon en temas daarvan. Daar word getoon dat die tematiese stryd met kwessies soos identiteit, geloof en liefde in dié woordkuns verband hou met die sosiopolitieke konteks van die Zoomer-generasie. Hierdie metamodernistiese toestand word gekenmerk deur progressiewe denke, diversiteit en ʼn samelewing wat voortdurend verander. Die gevolgtrekking word gemaak dat Afrikaanse Instagrampoësie ʼn literêre diskoers skep met die doel om nuwe idees met betrekking tot die waarhede van ʼn generasie wat dikwels misverstaan en misgekyk word, voor te stel. Die vryheid van Instagrampoësie bied met ander woorde ʼn geleentheid vir Zoomer-denkers om hulle stempel binne ʼn metamoderne samelewing af te druk. Deur Even-Zohar se 1 Instagram-terme wat verwys na die hoeveelheid mense wat die digter volg, sy/haar/sig gedigte lees en dan ook daarop reageer op ʼn “hou van/hou nie van nie” glyskaal. 4 polisisteemteorie en die leser-reaksie-teorie by die ondersoek na die skep en ontvangs van aanlyn poësie te betrek, word aangetoon dat e-letterkunde wel ʼn plek binne die Afrikaanse literêre diskoers vind. Hoewel die skeppingsproses, publikasie en ontvangs van aanlyn poësie verskil van dié van ander literêre vorme, stel die studie hierdie vorm van poësie aan die Afrikaanse literêre diskoers en kanon bekend. , Thesis (MA) -- Faculty of Humanities, 2023
- Full Text:
- Date Issued: 2023-12
A Combined Experimental and Computational Study of Hydridospirophosphorane Ligand Systems Featuring Halogenated Mandelic Acids
- Authors: Maritz, Marius Johann
- Date: 2023-12
- Subjects: Organic compounds -- Synthesis , Heterocyclic compounds , catalysis -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62096 , vital:71911
- Description: The search for new stereoselective catalysts remains important for the isolation of enantiomeric products from racemic mixtures. The need exists for these catalysts to be more efficient, to be more cost effective as well as be stable over time without undergoing changes in molecular structure and selectivity. The purpose of this research project was to experimentally synthesise and characterise asymmetric catalysts for the use in enantioselective synthesis. The catalysts consisted of the main group element phosphorous as central atom, with the phenyl rings of mandelic acid ligands monosubstituted with halogen atoms fluorine, chlorine and bromine in different configurations. Ligand binding resulted in the formation of hydridospirophosphorane structures, from which the molecular properties and binding geometry of these molecules could be explained by the theory of apicophilicity. Characterization was performed by NMR and IR spectroscopy as well as diffraction studies that provided the experimental crystal structures. The structural, energetic and spectroscopy results were compared to the theoretically obtained molecular properties using DFT analysis. Various interand intramolecular interactions that existed between molecules found in crystal packing environments were discussed. Additional properties that were investigated included modelling solvation effects, molecular orbital analysis, Hirshfeld surfaces, orbital and atomic energy and population analysis as well as ESP energy calculations with the optimized crystal structures as input. Molecular overlay comparisons were also performed between the experimental and optimized structures where the effectiveness of various DFT functionals and basis sets could be determined. The method with the best overall cost-to-accuracy ratio was found to be the triple-zeta def2-tzvp basis set with B3LYP functional theory and the addition of Grimme’s dispersion correction. Results indicated differences in crystal packing depending largely on the given halogen atoms present in the substituted phenyl rings, with differences observed in electronegativity and steric effects. One of the crystal systems showed additional interactions with solvent molecules, giving the impression that obtaining crystal void formation was possible. Alterations in the transition state activation energies between the isomers of each molecule were found to be present and supported the theory behind the mechanism of stereochemical induction. The studied compounds were therefore effective in isolating different enantiomeric ligands by means of energy differences between conformers and displayed unique catalytic properties resulting from the phosphorous main group element. The hydridospirophosphoranes conformers responsible for the lowest theoretically calculated activation energy induced crystallization as was seen by diffraction results for all compounds. Even as an intriguing observation, crystallization will largely depend on solubility rather than a specific conformer’s amount in solution. , Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: Maritz, Marius Johann
- Date: 2023-12
- Subjects: Organic compounds -- Synthesis , Heterocyclic compounds , catalysis -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62096 , vital:71911
- Description: The search for new stereoselective catalysts remains important for the isolation of enantiomeric products from racemic mixtures. The need exists for these catalysts to be more efficient, to be more cost effective as well as be stable over time without undergoing changes in molecular structure and selectivity. The purpose of this research project was to experimentally synthesise and characterise asymmetric catalysts for the use in enantioselective synthesis. The catalysts consisted of the main group element phosphorous as central atom, with the phenyl rings of mandelic acid ligands monosubstituted with halogen atoms fluorine, chlorine and bromine in different configurations. Ligand binding resulted in the formation of hydridospirophosphorane structures, from which the molecular properties and binding geometry of these molecules could be explained by the theory of apicophilicity. Characterization was performed by NMR and IR spectroscopy as well as diffraction studies that provided the experimental crystal structures. The structural, energetic and spectroscopy results were compared to the theoretically obtained molecular properties using DFT analysis. Various interand intramolecular interactions that existed between molecules found in crystal packing environments were discussed. Additional properties that were investigated included modelling solvation effects, molecular orbital analysis, Hirshfeld surfaces, orbital and atomic energy and population analysis as well as ESP energy calculations with the optimized crystal structures as input. Molecular overlay comparisons were also performed between the experimental and optimized structures where the effectiveness of various DFT functionals and basis sets could be determined. The method with the best overall cost-to-accuracy ratio was found to be the triple-zeta def2-tzvp basis set with B3LYP functional theory and the addition of Grimme’s dispersion correction. Results indicated differences in crystal packing depending largely on the given halogen atoms present in the substituted phenyl rings, with differences observed in electronegativity and steric effects. One of the crystal systems showed additional interactions with solvent molecules, giving the impression that obtaining crystal void formation was possible. Alterations in the transition state activation energies between the isomers of each molecule were found to be present and supported the theory behind the mechanism of stereochemical induction. The studied compounds were therefore effective in isolating different enantiomeric ligands by means of energy differences between conformers and displayed unique catalytic properties resulting from the phosphorous main group element. The hydridospirophosphoranes conformers responsible for the lowest theoretically calculated activation energy induced crystallization as was seen by diffraction results for all compounds. Even as an intriguing observation, crystallization will largely depend on solubility rather than a specific conformer’s amount in solution. , Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2023
- Full Text:
- Date Issued: 2023-12
A qualitative review on the manner in which psychologists address language barriers in psychological testing with isiXhosa speaking clients.
- Authors: Fouche, Nicoleen
- Date: 2023-12
- Subjects: language barriers , isiXhosa , psychological tests,
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62838 , vital:73055
- Description: A racially segregated culture historically influenced the growth of psychological testing and evaluation in South Africa. Thus, South Africa's multicultural and multilingual community poses difficulties for psychologists in their daily work. Most of the psychological tests used by psychologists are predominantly normed in either or only English/Afrikaans. Given the economic and professional resources required to develop new standardised tests for the broader South African population, the current status quo is set to continue for the foreseeable future. Consequently, language barriers pose a challenge when psychometric standardised tests are administered in a language that is different from that of the client, and as a result, psychologists must develop ways to enhance the fairness of these measures for their client base. The avenue of research that was explored is how psychologists overcome the language boundary when assessing clients who speak an indigenous first language, particularly isiXhosa. As such, this study explored this question through qualitative methods. Through purposive sampling, nine psychologists were invited to share their practical expertise on this topic, using semi-structured online interviews. The findings of this study suggested several core themes providing useful methods for other psychologists facing the same challenge, including the challenges with administering psychological tests with isiXhosa clients, the availability of standardised tests in the South African context, and the importance of determining the client’s language proficiency. Five themes with several sub-themes emerged from the study. The study contributes to the currently limited existing body of knowledge, and subsequently to the research area that this study explores - thus further providing guidelines that practitioners can employ when working with clients who are isiXhosa speaking. , Thesis (Ma) -- Faculty of Health Science, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: Fouche, Nicoleen
- Date: 2023-12
- Subjects: language barriers , isiXhosa , psychological tests,
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62838 , vital:73055
- Description: A racially segregated culture historically influenced the growth of psychological testing and evaluation in South Africa. Thus, South Africa's multicultural and multilingual community poses difficulties for psychologists in their daily work. Most of the psychological tests used by psychologists are predominantly normed in either or only English/Afrikaans. Given the economic and professional resources required to develop new standardised tests for the broader South African population, the current status quo is set to continue for the foreseeable future. Consequently, language barriers pose a challenge when psychometric standardised tests are administered in a language that is different from that of the client, and as a result, psychologists must develop ways to enhance the fairness of these measures for their client base. The avenue of research that was explored is how psychologists overcome the language boundary when assessing clients who speak an indigenous first language, particularly isiXhosa. As such, this study explored this question through qualitative methods. Through purposive sampling, nine psychologists were invited to share their practical expertise on this topic, using semi-structured online interviews. The findings of this study suggested several core themes providing useful methods for other psychologists facing the same challenge, including the challenges with administering psychological tests with isiXhosa clients, the availability of standardised tests in the South African context, and the importance of determining the client’s language proficiency. Five themes with several sub-themes emerged from the study. The study contributes to the currently limited existing body of knowledge, and subsequently to the research area that this study explores - thus further providing guidelines that practitioners can employ when working with clients who are isiXhosa speaking. , Thesis (Ma) -- Faculty of Health Science, 2023
- Full Text:
- Date Issued: 2023-12
A study exploring the understanding and interpretations of schizophrenia amongst Zulu Community members, in Durban, Kwa-Zulu Natal Province
- Authors: Lephoto, Thabo
- Date: 2023-12
- Subjects: chizophrenia , traditional healers , cultural belief,
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62859 , vital:73059
- Description: Mental illness is a global and widespread phenomenon, and its presented symptoms are experienced differently within various contexts. In many contexts, cultural beliefs are noted as influencing the thinking, feeling, and behavior of individuals and groups. Schizophrenia is often associated with a clustering of symptoms, which are often interpreted from within a cultural lens. This is in part, due to the lack of access to mental health facilities, and the limited understanding of psychological processes, but primarily due to cultural belief systems. As such, many individuals rely on indigenous knowledge systems and traditional healing when experiencing psychological symptoms. Within South Africa, the symptoms associated with schizophrenia are understood and treated in accordance with cultural beliefs and it is likely that bewitchment, spirit possession, as well as ancestral callings such as ukuthwasa, etc. will be associated with the symptoms of mental illnesses. The implications that this poses to psychological treatments and interventions are vast and require exploration. This study employed a qualitative methodology, with an exploratory and descriptive design. There were 8 participants (males= 4; females= 4), aged between 26-37 that were recruited for the study by utilizing a purposive sampling strategy, as well as a snowball sampling technique. Thematic analysis was used as a means of data analysis, by following the method by Braun and Clarke. The study applies the principles of ethics with regard to confidentiality and privacy. The findings of the study revealed that participants’ perceptions of schizophrenia were influenced by their culture. Participants of the study suggested that culture is influential in the treatment of those diagnosed with schizophrenia. Furthermore, the study revealed that there is a hierarchical system in the Zulu Culture and those diagnosed with schizophrenia are placed at the bottom. , Thesis (Ma) -- Faculty of Health Science, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: Lephoto, Thabo
- Date: 2023-12
- Subjects: chizophrenia , traditional healers , cultural belief,
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62859 , vital:73059
- Description: Mental illness is a global and widespread phenomenon, and its presented symptoms are experienced differently within various contexts. In many contexts, cultural beliefs are noted as influencing the thinking, feeling, and behavior of individuals and groups. Schizophrenia is often associated with a clustering of symptoms, which are often interpreted from within a cultural lens. This is in part, due to the lack of access to mental health facilities, and the limited understanding of psychological processes, but primarily due to cultural belief systems. As such, many individuals rely on indigenous knowledge systems and traditional healing when experiencing psychological symptoms. Within South Africa, the symptoms associated with schizophrenia are understood and treated in accordance with cultural beliefs and it is likely that bewitchment, spirit possession, as well as ancestral callings such as ukuthwasa, etc. will be associated with the symptoms of mental illnesses. The implications that this poses to psychological treatments and interventions are vast and require exploration. This study employed a qualitative methodology, with an exploratory and descriptive design. There were 8 participants (males= 4; females= 4), aged between 26-37 that were recruited for the study by utilizing a purposive sampling strategy, as well as a snowball sampling technique. Thematic analysis was used as a means of data analysis, by following the method by Braun and Clarke. The study applies the principles of ethics with regard to confidentiality and privacy. The findings of the study revealed that participants’ perceptions of schizophrenia were influenced by their culture. Participants of the study suggested that culture is influential in the treatment of those diagnosed with schizophrenia. Furthermore, the study revealed that there is a hierarchical system in the Zulu Culture and those diagnosed with schizophrenia are placed at the bottom. , Thesis (Ma) -- Faculty of Health Science, 2023
- Full Text:
- Date Issued: 2023-12
Adherence narratives of COVID-19 in KwaNobuhle Township, Eastern Cape
- Authors: Andries, Siyanda
- Date: 2023-12
- Subjects: Coronavirus Disease--Eastern Cape--South Africa , Vaccination--Eastern Cape, South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63243 , vital:73240
- Description: The emergence of COVID-19 triggered a global health crisis that not only took many lives but disrupted economies, strained healthcare systems, and impacted social relations globally. KwaNobuhle township in the Eastern Cape province of South Africa falls under the Nelson Mandela Bay Metropolitan Municipality. This municipality experienced some of South Africa’s highest COVID-19 fatalities, with the lowest levels of testing, active cases and hospitalisation in the country. This study investigates the narratives about COVID-19 prevention measures in KwaNobuhle. Primarily, it seeks to reveal how young and elderly peoples’ perceptions about COVID-19 influenced their compliance with prevention measures such as lockdown, testing and self-admission to hospital when sick. Fifteen residents of KwaNobuhle, who identify as Black people between 18 and 30 years and 50 and 65 years, were recruited as participants in this study. The two groups of study participants were recruited in order to enable an investigation into intergenerational narratives about infectious disease. In this study, Intergenerational narratives encompass stories, beliefs, and cultural traditions that transmit values, historical experiences, and a shared sense of identity, fostering connections between generations. This study provides an historical overview of how communities dealt with previous epidemics in South Africa and analyses how COVID-19 disrupted the lives of people with the preventative measures and changes that were implemented by the government. Social constructivism is a theory that emphasizes the role of social interactions and cultural context in shaping individuals' understanding of the world. Social constructivism theory is employed to frame the investigation of narratives of COVID-19 and is based on qualitative data collected through in-depth telephonic individual interviews. The data reveals that participants’ perceptions and narratives of diseases are shaped and influenced by their experiences and knowledge of the same. The findings confirm that the two different age groups of participants have distinct perspectives of COVID-19. Older participants rely on their past experiences of diseases, while younger participants form their understanding through mainstream and social media. This study further examines the inadequacy of healthcare system preparedness in South Africa to adequately address the onset of infectious diseases. Furthermore, this investigation unveils the way preventive measures against COVID-19 imposed inconvenience upon individuals' daily lives and overall lifestyles. These measures included curfews, a limitation on crowd size in public spaces vii such as markets, and the prohibition of alcohol consumption. Individuals who were reliant on the alcohol industry as their primary source of income were adversely affected. African traditional practices were also impacted, as burial custom alterations resulted. Lastly, the study illuminates that the acceptance and uptake of vaccinations was influenced by vaccine hesitancy, with social media serving as a prominent conduit for the proliferation of conspiracy theories in the context of COVID-19. , Thesis (Ma) -- Faculty of Humanities, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: Andries, Siyanda
- Date: 2023-12
- Subjects: Coronavirus Disease--Eastern Cape--South Africa , Vaccination--Eastern Cape, South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63243 , vital:73240
- Description: The emergence of COVID-19 triggered a global health crisis that not only took many lives but disrupted economies, strained healthcare systems, and impacted social relations globally. KwaNobuhle township in the Eastern Cape province of South Africa falls under the Nelson Mandela Bay Metropolitan Municipality. This municipality experienced some of South Africa’s highest COVID-19 fatalities, with the lowest levels of testing, active cases and hospitalisation in the country. This study investigates the narratives about COVID-19 prevention measures in KwaNobuhle. Primarily, it seeks to reveal how young and elderly peoples’ perceptions about COVID-19 influenced their compliance with prevention measures such as lockdown, testing and self-admission to hospital when sick. Fifteen residents of KwaNobuhle, who identify as Black people between 18 and 30 years and 50 and 65 years, were recruited as participants in this study. The two groups of study participants were recruited in order to enable an investigation into intergenerational narratives about infectious disease. In this study, Intergenerational narratives encompass stories, beliefs, and cultural traditions that transmit values, historical experiences, and a shared sense of identity, fostering connections between generations. This study provides an historical overview of how communities dealt with previous epidemics in South Africa and analyses how COVID-19 disrupted the lives of people with the preventative measures and changes that were implemented by the government. Social constructivism is a theory that emphasizes the role of social interactions and cultural context in shaping individuals' understanding of the world. Social constructivism theory is employed to frame the investigation of narratives of COVID-19 and is based on qualitative data collected through in-depth telephonic individual interviews. The data reveals that participants’ perceptions and narratives of diseases are shaped and influenced by their experiences and knowledge of the same. The findings confirm that the two different age groups of participants have distinct perspectives of COVID-19. Older participants rely on their past experiences of diseases, while younger participants form their understanding through mainstream and social media. This study further examines the inadequacy of healthcare system preparedness in South Africa to adequately address the onset of infectious diseases. Furthermore, this investigation unveils the way preventive measures against COVID-19 imposed inconvenience upon individuals' daily lives and overall lifestyles. These measures included curfews, a limitation on crowd size in public spaces vii such as markets, and the prohibition of alcohol consumption. Individuals who were reliant on the alcohol industry as their primary source of income were adversely affected. African traditional practices were also impacted, as burial custom alterations resulted. Lastly, the study illuminates that the acceptance and uptake of vaccinations was influenced by vaccine hesitancy, with social media serving as a prominent conduit for the proliferation of conspiracy theories in the context of COVID-19. , Thesis (Ma) -- Faculty of Humanities, 2023
- Full Text:
- Date Issued: 2023-12
An architecture for feedback-driven learning analytics
- Authors: Winfield, Philip John
- Date: 2023-12
- Subjects: Educational statistics -- Data processing , Education -- Research -- Statistical methods , Teacher-student relationships
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62744 , vital:72935
- Description: Feedback from students provides an opportunity to gain insights into students’ learning behaviour and participation in higher education learning and teaching. Academic staff are expected to constantly review and improve the learning and teaching environment where feedback contributes vital information toward pedagogical decision-making. Reviewing student feedback is essential but time-consuming, making it crucial to explore more effective and efficient ways to analyse and present feedback that encourages intervention and support. The general design science research evaluation pattern guided the construction and evaluation of a Feedback-Driven Architecture (FDA) for Learning Analytics (LA) to address this problem. An FDA implementation using a suitable case demonstrated each component validating the feasibility and effectiveness of the proposed design. The components identified for inclusion in the FDA were integrated within layers of a three-tiered architecture pattern. The data layer incorporates the collection, preparation and storage of learning management system data which includes free-form narrative student feedback. The application layer contains logic to support the analysis of free-form narrative student feedback and extraction of learning analytics. Arrangement and visualisation of information in the presentation layer aim to promote appropriate intervention and support. Evaluation using a case study showed that the FDA provided necessary guidelines for developing an implementation that produced feedbackdriven learning analytics. Data preparation transformed unstructured data into a suitable representation for effective analysis. Cohorts within narrative feedback responses were identified using the k-means clustering algorithm and latent Dirichlet allocation. Logistic regression and support vector machines were applied as predictive models and trained using extracted quantitative markers to predict academic success. , Thesis (MSc) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: Winfield, Philip John
- Date: 2023-12
- Subjects: Educational statistics -- Data processing , Education -- Research -- Statistical methods , Teacher-student relationships
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62744 , vital:72935
- Description: Feedback from students provides an opportunity to gain insights into students’ learning behaviour and participation in higher education learning and teaching. Academic staff are expected to constantly review and improve the learning and teaching environment where feedback contributes vital information toward pedagogical decision-making. Reviewing student feedback is essential but time-consuming, making it crucial to explore more effective and efficient ways to analyse and present feedback that encourages intervention and support. The general design science research evaluation pattern guided the construction and evaluation of a Feedback-Driven Architecture (FDA) for Learning Analytics (LA) to address this problem. An FDA implementation using a suitable case demonstrated each component validating the feasibility and effectiveness of the proposed design. The components identified for inclusion in the FDA were integrated within layers of a three-tiered architecture pattern. The data layer incorporates the collection, preparation and storage of learning management system data which includes free-form narrative student feedback. The application layer contains logic to support the analysis of free-form narrative student feedback and extraction of learning analytics. Arrangement and visualisation of information in the presentation layer aim to promote appropriate intervention and support. Evaluation using a case study showed that the FDA provided necessary guidelines for developing an implementation that produced feedbackdriven learning analytics. Data preparation transformed unstructured data into a suitable representation for effective analysis. Cohorts within narrative feedback responses were identified using the k-means clustering algorithm and latent Dirichlet allocation. Logistic regression and support vector machines were applied as predictive models and trained using extracted quantitative markers to predict academic success. , Thesis (MSc) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics, 2023
- Full Text:
- Date Issued: 2023-12
Assessing land degradation and the effectiveness of calcrete bontveld rehabilitation in a grassridge PPC cement mining area using multi-sensor remotely sensed data and machine learning techniques
- Authors: Mpisane, Khanyisa
- Date: 2023-12
- Subjects: Land degradation -- South Africa , Environmental degradation , Mines and mineral resources -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62527 , vital:72821
- Description: This study uses multi-temporal remote sensing data to spatially visualise and quantify land degradation due to mining as well as Calcrete Bontveld rehabilitation at the Grassridge PPC Cement mine, Gqeberha formerly known as Port Elizabeth in the Eastern Cape, South Africa. Botanical field data is also used to verify the suasses of rehabilitation in the area. SPOT-6 and Landsat multi-spectral images were compared, and Support Vector Machine and Random Forest algorithms were used for classification in order to determine which yields more accurate results for a limestone mine. Support Vector Machine analysis using SPOT-6 images yielded the best results. This was due to the high spatial resolution of SPOT-6 compared to Landsat and Support Vector Machine classifier was able to classify images with fewer training points compared to Random Forest. The spatio-temporal land cover change at the mine was then determined between the years 2000, 2015 and 2020. Land cover classification is useful for monitoring land degradation and, in this case, was able to show the extent of rehabilitation success. For the year 2020, a 17% area was rehabilitated; however, the algorithm could not distinguish between unmined Calcrete Bontveld matrix and rehabilitation sites that were older than five years. The performed change detection also showed that 29.50% of unmined Calcrete Bontveld matrix had changed to “mature rehabilitation” (rehabilitation sites older than five years). Again, for this percentage in some areas the algorithm could not distinguish between the unmined Calcrete Bontveld matrix and rehabilitation sites that were older than five years due to high similarities between the two land cover types. Area changes of the different land cover classes could also be used to demonstrate how rehabilitation areas have matured over time and lead to the conclusion that most of the Calcrete Bontveld which was mined, has over the years been successfully rehabilitated. Vegetation analysis was conducted to further validate the rehabilitation success of Calcrete Bontveld matrix. Multivariant Detrended Correspondent Analysis showed that rehabilitation sites which were younger than five years (2–year-old rehabilitation plots that were sampled) had great dissimilarity to the natural unmined Calcrete Bontveld matrix and that rehabilitation sites older than five years, in this case 16–years older, had high similarity and resemblance to natural unmined Calcrete Bontveld matrix and therefore could be considered as being mature. This was a more definitive assessment as it considers all aspects of the vegetation. Species cover and species richness also showed that Calcrete Bontveld matrix rehabilitation sites which have been rehabilitated for more than 5 years had greater similarity to natural unmined vegetation compared to areas that have been rehabilitated for less than five years. This study, therefore, demonstrates that due to the high similarity between mature rehabilitation sites and unmined Calcrete Bontveld, rehabilitation has been successful. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: Mpisane, Khanyisa
- Date: 2023-12
- Subjects: Land degradation -- South Africa , Environmental degradation , Mines and mineral resources -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62527 , vital:72821
- Description: This study uses multi-temporal remote sensing data to spatially visualise and quantify land degradation due to mining as well as Calcrete Bontveld rehabilitation at the Grassridge PPC Cement mine, Gqeberha formerly known as Port Elizabeth in the Eastern Cape, South Africa. Botanical field data is also used to verify the suasses of rehabilitation in the area. SPOT-6 and Landsat multi-spectral images were compared, and Support Vector Machine and Random Forest algorithms were used for classification in order to determine which yields more accurate results for a limestone mine. Support Vector Machine analysis using SPOT-6 images yielded the best results. This was due to the high spatial resolution of SPOT-6 compared to Landsat and Support Vector Machine classifier was able to classify images with fewer training points compared to Random Forest. The spatio-temporal land cover change at the mine was then determined between the years 2000, 2015 and 2020. Land cover classification is useful for monitoring land degradation and, in this case, was able to show the extent of rehabilitation success. For the year 2020, a 17% area was rehabilitated; however, the algorithm could not distinguish between unmined Calcrete Bontveld matrix and rehabilitation sites that were older than five years. The performed change detection also showed that 29.50% of unmined Calcrete Bontveld matrix had changed to “mature rehabilitation” (rehabilitation sites older than five years). Again, for this percentage in some areas the algorithm could not distinguish between the unmined Calcrete Bontveld matrix and rehabilitation sites that were older than five years due to high similarities between the two land cover types. Area changes of the different land cover classes could also be used to demonstrate how rehabilitation areas have matured over time and lead to the conclusion that most of the Calcrete Bontveld which was mined, has over the years been successfully rehabilitated. Vegetation analysis was conducted to further validate the rehabilitation success of Calcrete Bontveld matrix. Multivariant Detrended Correspondent Analysis showed that rehabilitation sites which were younger than five years (2–year-old rehabilitation plots that were sampled) had great dissimilarity to the natural unmined Calcrete Bontveld matrix and that rehabilitation sites older than five years, in this case 16–years older, had high similarity and resemblance to natural unmined Calcrete Bontveld matrix and therefore could be considered as being mature. This was a more definitive assessment as it considers all aspects of the vegetation. Species cover and species richness also showed that Calcrete Bontveld matrix rehabilitation sites which have been rehabilitated for more than 5 years had greater similarity to natural unmined vegetation compared to areas that have been rehabilitated for less than five years. This study, therefore, demonstrates that due to the high similarity between mature rehabilitation sites and unmined Calcrete Bontveld, rehabilitation has been successful. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2023
- Full Text:
- Date Issued: 2023-12
Assessing the effectiveness of smart solutions on potable water in rural areas within Ngqushwa local municipality
- Authors: Fodo, Portia Noluthando
- Date: 2023-12
- Subjects: Potable water -- tap water , water infrastructure
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63298 , vital:73245
- Description: Providing potable water is a critical reposition towards achieving the Sustainable Development Goal (SDG) 6, to ensure the availability and sustainable management of water and sanitation for all. In addition, the use of smart solutions facilitates towards guaranteeing smart cities aligned with SDG11 which is aimed at making cities and human settlements inclusive, secure, resilient and viable. Access to potable water is a challenging issue in most rural areas as these areas were affected by the Apartheid regime where services were distributed according to the colour of the skin. In rural areas where many black people reside, the challenge of service delivery still exists. Ngqushwa Municipality is faced with several trials in the management of water, including water scarcity, lack of water infrastructure as well as illegal water connections. Despite more than 25 years of democracy, rural dwellers in Ngqushwa Municipality still suffer from a deficiency of access to potable water, which results in other health problems, such as Cholera. This study was aimed at assessing the role of smart solutions in the effective management of potable water in rural areas in Ngqushwa Local Municipality. The objectives to be achieved include identification of the policies that support the implementation of smart solutions in the provision of potable water in Ngqushwa Local Municipality, as well as determining the opportunities and challenges associated with smart solutions in the delivery of potable water. Moreover, identifying the existing difficulties affecting the execution of smart solutions in the delivery of potable water, along with developing recommendations on how smart solutions can effectively be put into operation in rural areas to control water. A qualitative research approach was applied as the chosen research methodology most appropriate to achieving the objectives of the research study. Data was collected using secondary sources and was analysed using thematic content analysis. The study revealed that opportunities available include accurate billing, smart metering and information availability. Furthermore, the obstacles included capacity constraints, cost factors and resistance to change. The investigation recommended, inter alia, that the municipality should accurately train its employees on matters relating to change management and establish effective debt controlling mechanisms to enhance water supervision in rural areas. , Thesis (MA) -- Faculty of Humanities, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: Fodo, Portia Noluthando
- Date: 2023-12
- Subjects: Potable water -- tap water , water infrastructure
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63298 , vital:73245
- Description: Providing potable water is a critical reposition towards achieving the Sustainable Development Goal (SDG) 6, to ensure the availability and sustainable management of water and sanitation for all. In addition, the use of smart solutions facilitates towards guaranteeing smart cities aligned with SDG11 which is aimed at making cities and human settlements inclusive, secure, resilient and viable. Access to potable water is a challenging issue in most rural areas as these areas were affected by the Apartheid regime where services were distributed according to the colour of the skin. In rural areas where many black people reside, the challenge of service delivery still exists. Ngqushwa Municipality is faced with several trials in the management of water, including water scarcity, lack of water infrastructure as well as illegal water connections. Despite more than 25 years of democracy, rural dwellers in Ngqushwa Municipality still suffer from a deficiency of access to potable water, which results in other health problems, such as Cholera. This study was aimed at assessing the role of smart solutions in the effective management of potable water in rural areas in Ngqushwa Local Municipality. The objectives to be achieved include identification of the policies that support the implementation of smart solutions in the provision of potable water in Ngqushwa Local Municipality, as well as determining the opportunities and challenges associated with smart solutions in the delivery of potable water. Moreover, identifying the existing difficulties affecting the execution of smart solutions in the delivery of potable water, along with developing recommendations on how smart solutions can effectively be put into operation in rural areas to control water. A qualitative research approach was applied as the chosen research methodology most appropriate to achieving the objectives of the research study. Data was collected using secondary sources and was analysed using thematic content analysis. The study revealed that opportunities available include accurate billing, smart metering and information availability. Furthermore, the obstacles included capacity constraints, cost factors and resistance to change. The investigation recommended, inter alia, that the municipality should accurately train its employees on matters relating to change management and establish effective debt controlling mechanisms to enhance water supervision in rural areas. , Thesis (MA) -- Faculty of Humanities, 2023
- Full Text:
- Date Issued: 2023-12
Assessing the effectiveness of the planning, utilisation and implementation of the electronic human resource management strategy: a case of the department of home affairs in the Eastern Cape
- Authors: Dyan, Margaret Nombuyiselo
- Date: 2023-12
- Subjects: Personnel management , Home Affairs -- Eastern Cape
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63287 , vital:73244
- Description: This study assessed the effectiveness of planning, implementing and utilising the electronic human resource management (e-HRM) strategy within the King William’s Town (KWT) Department of Home Affairs (DHA) in the Eastern Cape Province (EC) of South Africa (SA). E-HRM emerged because of the advent of technology. Many organisations use information technology to optimise the performance of both the employees and the organisation. Thus, this technology has been incorporated into organisations’ human resource functions, taking advantage of the latest technology to deliver an online real-time human resource management (HRM) solution. Therefore, this study sought to assess the e-HRM strategy's effectiveness within the KWT DHA. The technology acceptance model was adopted as a theoretical framework for the study to explain the adoption of the e-HRM strategy. A qualitative research approach using a case study research design was used for this study. Non-probability purposive sampling and convenience sampling were used to identify participants for the study. These participants provided the information needed to answer the research questions. The data was collected using in-depth interviews with the participants. The data was then analysed using thematic analysis following Braun and Clarke’s guidelines (2006). The study results revealed that implementing the e-HRM strategy within KWT DHA proves to be effective and efficient. The strategy’s implementation has been associated with improved performance of the KWT DHA in the Eastern Cape. It also saves time and ensures that HR information is accessed easily. The study also found barriers to the planning, implementation and utilisation of the e-HRM strategy, including a lack of skills and knowledge and resource constraints. The study also found that the current e-HRM policies are not fully functional. The study recommends continuous personnel training regarding the strategy, maximising the use of the e-HRM strategy and addressing the resource challenges. , Thesis (MA) -- Faculty of Humanities, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: Dyan, Margaret Nombuyiselo
- Date: 2023-12
- Subjects: Personnel management , Home Affairs -- Eastern Cape
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63287 , vital:73244
- Description: This study assessed the effectiveness of planning, implementing and utilising the electronic human resource management (e-HRM) strategy within the King William’s Town (KWT) Department of Home Affairs (DHA) in the Eastern Cape Province (EC) of South Africa (SA). E-HRM emerged because of the advent of technology. Many organisations use information technology to optimise the performance of both the employees and the organisation. Thus, this technology has been incorporated into organisations’ human resource functions, taking advantage of the latest technology to deliver an online real-time human resource management (HRM) solution. Therefore, this study sought to assess the e-HRM strategy's effectiveness within the KWT DHA. The technology acceptance model was adopted as a theoretical framework for the study to explain the adoption of the e-HRM strategy. A qualitative research approach using a case study research design was used for this study. Non-probability purposive sampling and convenience sampling were used to identify participants for the study. These participants provided the information needed to answer the research questions. The data was collected using in-depth interviews with the participants. The data was then analysed using thematic analysis following Braun and Clarke’s guidelines (2006). The study results revealed that implementing the e-HRM strategy within KWT DHA proves to be effective and efficient. The strategy’s implementation has been associated with improved performance of the KWT DHA in the Eastern Cape. It also saves time and ensures that HR information is accessed easily. The study also found barriers to the planning, implementation and utilisation of the e-HRM strategy, including a lack of skills and knowledge and resource constraints. The study also found that the current e-HRM policies are not fully functional. The study recommends continuous personnel training regarding the strategy, maximising the use of the e-HRM strategy and addressing the resource challenges. , Thesis (MA) -- Faculty of Humanities, 2023
- Full Text:
- Date Issued: 2023-12
Assessment of knowledge, attitudes, practices and the prevalence of intestinal parasites in Sarah Baartman District, Eastern Cape
- Authors: Mrwebi, Sisanda
- Date: 2023-12
- Subjects: Intestinal parasites , Knowledge Attitudes and Practices , transmitted helminths
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62924 , vital:73070
- Description: ntestinal parasites also known as parasitic worms are one of the common water, soil and feacal transmitted infections of public importance in the world. This study evaluated the Knowledge, Attitudes and Practices (KAP) of public workers comprising EPWP and CWP general workers on intestinal parasites in a selected municipality in the study area . Additionally, using secondary data, the researcher established the prevalence of intestinal parasites in Sarah Baartman District Municipality (SBDM) from 2012 to 2020. Method: The study made use of a quantitative, cross-sectional research design resembling a study by S.D. Hambury .A structured questionnaire, closed-ended, telephonically-administered questionnaire was used to collect data from 160 Expanded Public Works Programme (EPWP) and Community Work Programme (CWP) general workers. Data on the prevalence was obtained from the SBDM National Health Laboratory Service (NHLS). Data was analysed using both inferential and descriptive statistics using SPSS software version 16.1, inferential statistics tests used were Chi2 square tests and p-value tests. Descriptive statistic tests used included frequency distributions, percentage, cumulative percent, and valid percent. Results: The participants’ overall awareness, attitudes and practices of the study were poor, 64.4% of the study participants had the correct knowledge about intestinal parasite infections. The age of study participants and who the participants thought was at risk of being infected by intestinal parasites had a non significant relationship (p>0.05). Gender and the responses to who is at risk of getting infected with intestinal parasites had a statistically significant (p<0.05) relationship. Intestinal parasite prevalence from 2012 to 2020 in SBDM was 46.37% which means it was close to half of the sampled population. Males had the highest prevalence as compared to females, with a prevalence of 53.1% xvi in males and 46.9% in females. The highest disease infection was found between ages one and six years. Conclusion: The researcher concluded that the overall awareness, attitudes and practices on intestinal parasites in SBDM were poor. The intestinal parasites present in SBDM were Cytoisospora belli (35.4%) and Giardia lamblia (35.4%), Ascaris lumbricoides (17.7%), Trichuris trichiura (3%), and Taenia species (2%). The study also revealed that the prevalence of intestinal parasites was low from 2012 to 2020. Recommendations were made with an emphasis on education to increase disease prevention and control awareness. , Thesis (Ma) -- Faculty of Health Science, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: Mrwebi, Sisanda
- Date: 2023-12
- Subjects: Intestinal parasites , Knowledge Attitudes and Practices , transmitted helminths
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62924 , vital:73070
- Description: ntestinal parasites also known as parasitic worms are one of the common water, soil and feacal transmitted infections of public importance in the world. This study evaluated the Knowledge, Attitudes and Practices (KAP) of public workers comprising EPWP and CWP general workers on intestinal parasites in a selected municipality in the study area . Additionally, using secondary data, the researcher established the prevalence of intestinal parasites in Sarah Baartman District Municipality (SBDM) from 2012 to 2020. Method: The study made use of a quantitative, cross-sectional research design resembling a study by S.D. Hambury .A structured questionnaire, closed-ended, telephonically-administered questionnaire was used to collect data from 160 Expanded Public Works Programme (EPWP) and Community Work Programme (CWP) general workers. Data on the prevalence was obtained from the SBDM National Health Laboratory Service (NHLS). Data was analysed using both inferential and descriptive statistics using SPSS software version 16.1, inferential statistics tests used were Chi2 square tests and p-value tests. Descriptive statistic tests used included frequency distributions, percentage, cumulative percent, and valid percent. Results: The participants’ overall awareness, attitudes and practices of the study were poor, 64.4% of the study participants had the correct knowledge about intestinal parasite infections. The age of study participants and who the participants thought was at risk of being infected by intestinal parasites had a non significant relationship (p>0.05). Gender and the responses to who is at risk of getting infected with intestinal parasites had a statistically significant (p<0.05) relationship. Intestinal parasite prevalence from 2012 to 2020 in SBDM was 46.37% which means it was close to half of the sampled population. Males had the highest prevalence as compared to females, with a prevalence of 53.1% xvi in males and 46.9% in females. The highest disease infection was found between ages one and six years. Conclusion: The researcher concluded that the overall awareness, attitudes and practices on intestinal parasites in SBDM were poor. The intestinal parasites present in SBDM were Cytoisospora belli (35.4%) and Giardia lamblia (35.4%), Ascaris lumbricoides (17.7%), Trichuris trichiura (3%), and Taenia species (2%). The study also revealed that the prevalence of intestinal parasites was low from 2012 to 2020. Recommendations were made with an emphasis on education to increase disease prevention and control awareness. , Thesis (Ma) -- Faculty of Health Science, 2023
- Full Text:
- Date Issued: 2023-12
Characterization of the coastal Aquifer of Gqeberha, South Africa : Developing a conceptual understanding
- Authors: Vandala, Bamanye
- Date: 2023-12
- Subjects: Aquifers -- South Africa -- Port Elizabeth , Groundwater ecology , Hydrogeology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62710 , vital:72932
- Description: The aquifer systems in Gqeberha are poorly understood due to a lack of groundwater studies within the area, and this is particularly the case for the coastal aquifer of Gqeberha. Amidst the water crisis the city is currently facing, groundwater has become crucial, with over 1000 boreholes reportedly drilled in the coastal area, most of which are residential. This has resulted in the need to conduct more groundwater studies in the area and in Nelson Mandela Bay. This study presents a detailed hydrogeological characterization of the coastal aquifer of Gqeberha. This was achieved through the use of different techniques, which include field mapping, geophysics, hydrochemistry, and pumping test analysis. The work was done on the coastal seeps of the Algoa Group Formation and the fractured aquifer of the Peninsula Formation. The results through mapping indicated an abundance of folds, faults, and fractures which all have implications for groundwater flow. The majority of fractures are striking in the NE-SW and NW-SE directions. The pumping test analysis also indicated fractal flow with significant matrix flow resulting in a dual porosity system up to at least 200m in depth. The transmissivity and storativity values range from 6.78 – 44.5 m2/day and 0.0172 – 0.0325, respectively. This is highly dependent on the fracture interconnectivity, which varies across the area and is higher at shallow depths, as suggested by the geophysical profiles. Geophysical profiles indicate that the contact between the Algoa Group Formations and the Peninsula Formation results in coastal seeps due to the difference in hydraulic conductivities. The hydrochemical analysis suggests that the seeps generally have Na-Cl and Ca-Mg-Cl water types. The groundwater in the eastern area has a Ca-HCO3 water type, and the groundwater in the western region has a Ca-Mg-Cl water type, with the Chelsea-Noordhoek Fault system separating the two groundwater signatures. Groundwater at greater depths has a Na-Cl water type with higher TDS values. The chemical signatures seen are due to external factors, which include sea sprays, anthropogenic activities, rock-water processes, and possibly connate water in the Peninsula Formation aquifer. The findings of this study offer valuable insights into the present conditions of the aquifer in Gqeberha. This research serves as a foundational study that can provide a baseline for future hydrogeological investigations in the area. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: Vandala, Bamanye
- Date: 2023-12
- Subjects: Aquifers -- South Africa -- Port Elizabeth , Groundwater ecology , Hydrogeology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62710 , vital:72932
- Description: The aquifer systems in Gqeberha are poorly understood due to a lack of groundwater studies within the area, and this is particularly the case for the coastal aquifer of Gqeberha. Amidst the water crisis the city is currently facing, groundwater has become crucial, with over 1000 boreholes reportedly drilled in the coastal area, most of which are residential. This has resulted in the need to conduct more groundwater studies in the area and in Nelson Mandela Bay. This study presents a detailed hydrogeological characterization of the coastal aquifer of Gqeberha. This was achieved through the use of different techniques, which include field mapping, geophysics, hydrochemistry, and pumping test analysis. The work was done on the coastal seeps of the Algoa Group Formation and the fractured aquifer of the Peninsula Formation. The results through mapping indicated an abundance of folds, faults, and fractures which all have implications for groundwater flow. The majority of fractures are striking in the NE-SW and NW-SE directions. The pumping test analysis also indicated fractal flow with significant matrix flow resulting in a dual porosity system up to at least 200m in depth. The transmissivity and storativity values range from 6.78 – 44.5 m2/day and 0.0172 – 0.0325, respectively. This is highly dependent on the fracture interconnectivity, which varies across the area and is higher at shallow depths, as suggested by the geophysical profiles. Geophysical profiles indicate that the contact between the Algoa Group Formations and the Peninsula Formation results in coastal seeps due to the difference in hydraulic conductivities. The hydrochemical analysis suggests that the seeps generally have Na-Cl and Ca-Mg-Cl water types. The groundwater in the eastern area has a Ca-HCO3 water type, and the groundwater in the western region has a Ca-Mg-Cl water type, with the Chelsea-Noordhoek Fault system separating the two groundwater signatures. Groundwater at greater depths has a Na-Cl water type with higher TDS values. The chemical signatures seen are due to external factors, which include sea sprays, anthropogenic activities, rock-water processes, and possibly connate water in the Peninsula Formation aquifer. The findings of this study offer valuable insights into the present conditions of the aquifer in Gqeberha. This research serves as a foundational study that can provide a baseline for future hydrogeological investigations in the area. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2023
- Full Text:
- Date Issued: 2023-12
Chemical analysis and biological activities of crude extracts and essential oil of selected medicinal plants from the Eastern Cape, South Africa, and Volta Region of Ghana
- Authors: Agbo, Irene Adzo
- Date: 2023-12
- Subjects: Medicinal plants , Lantana camara , Peptic ulcer -- Treatment , Traditional medicine - South Africa -- Eastern Cape , Traditional medicine -- Ghana
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62431 , vital:72728
- Description: Lantana camara and Khaya grandifoliola extracts are among many plants found traditionally effective for the treatment of wounds and ulcers. This study assessed the phytochemical content, isolation and identification of single compounds from methanol and ethyl acetate extracts of Lantana camara and Khaya grandifoliola. Further, the bioactivity testing including antioxidant, antimicrobial and cytoxicity of the extracts was done to confirm the wound healing potential discovered by the traditional healers. Materials and methods: Extraction was done successively using maceration method with 100 % ethyl acetate and 100 % methanol with a biomass-to-solvent ratio of 1:3 (w/v) to obtain L. camara ethyl acetate extracts of berry (ELB), flower (ELF) and leaf (ELL) and methanol extracts of MLB, MLF, MLL and K. grandifoliola ethyl acetate extracts of leaf (EKL), root (EKR) and stem bark (EKSB) and methanol extracts of MKL, MKR, MKSB respectively. L. camara leaf essential oil (EO) was extracted using the hydro-distillation method with a Clevenger apparatus. Total phytochemical content was assessed for each extract using spectrophotometric methods and a calibration curve of standards: bromocresol green method with atropine; Folin–Ciocalteu colorimetric method with gallic acid, aluminium chloride colorimetric method with quercetin and concentrated sulphuric acid chloroform with linalool for total alkaloid, phenolic, flavonoid and terpenoid contents respectively. Single compound isolation and purification was conducted using chromatographic techniques. Elucidation of single compounds was done using spectrometric method, high resolution- mass spectrometry, and one and two-dimensional (1D and 2D)-NMR. Stereochemistry of each compound was confirmed using electronic circular dichroism spectra. A Crystalline compound was identified by single crystal X-ray diffraction using CuKα-radiation. In vitro bioactivities were assessed with methods such as 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide, free radical scavenging activity of 1,1-diphenyl-2-picrylhydrazyl, inhibitory effect on nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages, and 96-well plate micro dilution for cytotoxicity, ant-inflammatory and antimicrobial activity testing. Results: Methanol extracts of both plants retained high phytochemical concentrations of all the phytoconstituents investigated compared with the ethyl acetate extracts which retained lower concentrations. The results of the L. camara methanol extracts include; total alkaloid content (TAC) (2.05±0.18, 1.87±1.54 and 2.60±1.10 mg AEQ/100 mg); total phenolic content (TPC) (14.05±4.04, 34.59±3.01 and 18.58±1.87 mg GAEQ/100 mg); the total flavonoid content(TFC) of flower (12.45±1.87, 20.41±2.69 and mg QEQ/100 mg); total terpenoids (TTC) (20.74±2.34, 20.74±2.34 and 15.97±1.19 mg LIN EQ/100mg) of MLB, MLF and MLL respectively. Whereas that of the K. grandifoliola methanol extracts include; TAC (7.32±0.14,8.49±0.34, 10.67±0.22 mg AEQ/100 mg); TPC (37.49±1.40, 44.41±0.69, 53.57±1.50 mgGAEQ/100 mg); TFC (6.54±0.55, 9.58±0.89 and 10.26±0.92 mg QEQ/100 mg); TTC(10.16±1.41, 35.78±2.14 and 23.45±1.76 mg LIN EQ/100mg) of MKL, MKR and MKSB respectively. The major components of essential oil, out of the 71 constituents identified include Davanone D (32.91 %), Caryophyllene (5.07 %), Nerolidol 2 (3.56 %) and GermacreneD (3.13 %). Compounds 3.47 was isolated from the methanol extract of L. camara flowers. This compound is reported for the first time from the L. camara flower extract. Two compounds, compounds 4.23, and 4.26, were isolated from the methanol extract of K. grandifoliola roots, compound 4.22 was isolated from the ethyl acetate root extract while compounds 4.24 and 4.25 were isolated from the ethyl acetate stem bark extract as isomers in a mixture. Compounds 4.22 and 4.23 are reported from K. grandifoliola root for the first time. The isolated compounds (compounds 3.47 and 4.23) were nontoxic to the Vero cell line and this may contribute to possible stimulation of cell proliferation, promoting wound healing. Cytotoxicity describes extract virulence to Vero cell line. MLF and ELB were found nontoxic even at the highest concentration of 200 μg/mL. The MKSB and MKR, as well as the EKSB were nontoxic. Antioxidant activity results, described by the percentage inhibition in the DPPH assay, showed that MLF and MKSB had the highest antioxidant activities compared with the ascorbic acid standard, with IC50 of 38.68±5.09 and 37.03±11.95 μg/mL for L. camara and K. grandifoliola respectively. ELB exhibited a significant anti-inflammatory activity inhibiting NO• radical generation in the LPS-stimulated RAW 264.7 macrophages at concentration ranging from 50 and 100 μg/mL. EKSB and MKR showed significant anti-inflammatory activity at 100 and 200 μg/ml respectively. ELL and ELF demonstrated potent growth inhibition against S. pyogenes with an MIC value ≤ 0.125 mg/mL, while the MICs of the ELB and MLL were 0.5 mg/mL and 2 mg/mL respectively. MKSB and MKR and EKSB extract exhibited an effective growth inhibition against S. aureus with MIC of 1 mg/mL. The growth of S. pyogenes was supressed by both ethyl acetate and methanol extracts of all plant parts tested with MIC ranging from 0.25–2 mg/mL. Conclusion: The potent bioactivity shown in the results of the cytotoxicity, antioxidant activity, anti-inflammatory and antimicrobial activity testing, and the nontoxic singlecompounds of L. camara and K. grandifoliola extracts led to the conclusion that the two plants had wound healing potential. The study therefore confirmed their traditional uses for treatment of wounds. , Thesis (PhD) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: Agbo, Irene Adzo
- Date: 2023-12
- Subjects: Medicinal plants , Lantana camara , Peptic ulcer -- Treatment , Traditional medicine - South Africa -- Eastern Cape , Traditional medicine -- Ghana
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/62431 , vital:72728
- Description: Lantana camara and Khaya grandifoliola extracts are among many plants found traditionally effective for the treatment of wounds and ulcers. This study assessed the phytochemical content, isolation and identification of single compounds from methanol and ethyl acetate extracts of Lantana camara and Khaya grandifoliola. Further, the bioactivity testing including antioxidant, antimicrobial and cytoxicity of the extracts was done to confirm the wound healing potential discovered by the traditional healers. Materials and methods: Extraction was done successively using maceration method with 100 % ethyl acetate and 100 % methanol with a biomass-to-solvent ratio of 1:3 (w/v) to obtain L. camara ethyl acetate extracts of berry (ELB), flower (ELF) and leaf (ELL) and methanol extracts of MLB, MLF, MLL and K. grandifoliola ethyl acetate extracts of leaf (EKL), root (EKR) and stem bark (EKSB) and methanol extracts of MKL, MKR, MKSB respectively. L. camara leaf essential oil (EO) was extracted using the hydro-distillation method with a Clevenger apparatus. Total phytochemical content was assessed for each extract using spectrophotometric methods and a calibration curve of standards: bromocresol green method with atropine; Folin–Ciocalteu colorimetric method with gallic acid, aluminium chloride colorimetric method with quercetin and concentrated sulphuric acid chloroform with linalool for total alkaloid, phenolic, flavonoid and terpenoid contents respectively. Single compound isolation and purification was conducted using chromatographic techniques. Elucidation of single compounds was done using spectrometric method, high resolution- mass spectrometry, and one and two-dimensional (1D and 2D)-NMR. Stereochemistry of each compound was confirmed using electronic circular dichroism spectra. A Crystalline compound was identified by single crystal X-ray diffraction using CuKα-radiation. In vitro bioactivities were assessed with methods such as 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide, free radical scavenging activity of 1,1-diphenyl-2-picrylhydrazyl, inhibitory effect on nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages, and 96-well plate micro dilution for cytotoxicity, ant-inflammatory and antimicrobial activity testing. Results: Methanol extracts of both plants retained high phytochemical concentrations of all the phytoconstituents investigated compared with the ethyl acetate extracts which retained lower concentrations. The results of the L. camara methanol extracts include; total alkaloid content (TAC) (2.05±0.18, 1.87±1.54 and 2.60±1.10 mg AEQ/100 mg); total phenolic content (TPC) (14.05±4.04, 34.59±3.01 and 18.58±1.87 mg GAEQ/100 mg); the total flavonoid content(TFC) of flower (12.45±1.87, 20.41±2.69 and mg QEQ/100 mg); total terpenoids (TTC) (20.74±2.34, 20.74±2.34 and 15.97±1.19 mg LIN EQ/100mg) of MLB, MLF and MLL respectively. Whereas that of the K. grandifoliola methanol extracts include; TAC (7.32±0.14,8.49±0.34, 10.67±0.22 mg AEQ/100 mg); TPC (37.49±1.40, 44.41±0.69, 53.57±1.50 mgGAEQ/100 mg); TFC (6.54±0.55, 9.58±0.89 and 10.26±0.92 mg QEQ/100 mg); TTC(10.16±1.41, 35.78±2.14 and 23.45±1.76 mg LIN EQ/100mg) of MKL, MKR and MKSB respectively. The major components of essential oil, out of the 71 constituents identified include Davanone D (32.91 %), Caryophyllene (5.07 %), Nerolidol 2 (3.56 %) and GermacreneD (3.13 %). Compounds 3.47 was isolated from the methanol extract of L. camara flowers. This compound is reported for the first time from the L. camara flower extract. Two compounds, compounds 4.23, and 4.26, were isolated from the methanol extract of K. grandifoliola roots, compound 4.22 was isolated from the ethyl acetate root extract while compounds 4.24 and 4.25 were isolated from the ethyl acetate stem bark extract as isomers in a mixture. Compounds 4.22 and 4.23 are reported from K. grandifoliola root for the first time. The isolated compounds (compounds 3.47 and 4.23) were nontoxic to the Vero cell line and this may contribute to possible stimulation of cell proliferation, promoting wound healing. Cytotoxicity describes extract virulence to Vero cell line. MLF and ELB were found nontoxic even at the highest concentration of 200 μg/mL. The MKSB and MKR, as well as the EKSB were nontoxic. Antioxidant activity results, described by the percentage inhibition in the DPPH assay, showed that MLF and MKSB had the highest antioxidant activities compared with the ascorbic acid standard, with IC50 of 38.68±5.09 and 37.03±11.95 μg/mL for L. camara and K. grandifoliola respectively. ELB exhibited a significant anti-inflammatory activity inhibiting NO• radical generation in the LPS-stimulated RAW 264.7 macrophages at concentration ranging from 50 and 100 μg/mL. EKSB and MKR showed significant anti-inflammatory activity at 100 and 200 μg/ml respectively. ELL and ELF demonstrated potent growth inhibition against S. pyogenes with an MIC value ≤ 0.125 mg/mL, while the MICs of the ELB and MLL were 0.5 mg/mL and 2 mg/mL respectively. MKSB and MKR and EKSB extract exhibited an effective growth inhibition against S. aureus with MIC of 1 mg/mL. The growth of S. pyogenes was supressed by both ethyl acetate and methanol extracts of all plant parts tested with MIC ranging from 0.25–2 mg/mL. Conclusion: The potent bioactivity shown in the results of the cytotoxicity, antioxidant activity, anti-inflammatory and antimicrobial activity testing, and the nontoxic singlecompounds of L. camara and K. grandifoliola extracts led to the conclusion that the two plants had wound healing potential. The study therefore confirmed their traditional uses for treatment of wounds. , Thesis (PhD) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2023
- Full Text:
- Date Issued: 2023-12
Effects of selected natural flavonoids on an optimized insulin resistance induction model on myotubes and hepatocytes in vitro
- Authors: Van de Venter, Ruben
- Date: 2023-12
- Subjects: Flavonoid , Insulin resistance , Myotubes and hepatocytes
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63049 , vital:73085
- Description: Introduction: As the third largest life-threatening non-communicable disease, further research to improve T2DM treatment remains pivotal. The approved insulin sensitizing agents, metformin and thiazolidinediones, although effective, have an array of adverse effects. This leads to the growing need for safer insulin sensitizing agents. Aims: To induce insulin resistance, an insulin resistance induction (IRI) model consisting of palmitic acid (PA), fructose, and dexamethasone (DEX), was optimized. The model was utilized to compare the insulin sensitizing efficacy of chrysin, apigenin, luteolin, and quercetin. The most effective flavonoid was extrapolated based on the hydroxylation hypothesis and relevant SAR. The flavonoid was combined with metformin to evaluate potential insulin sensitizing synergism. Methods: C3A hepatocytes and L6 myotubes were exposed to the IRI models: IR1, IR2, and OIR, for 24 and 48h. Morphological features indicative of insulin resistance were monitored through high-content analysis (HCA). Thereafter, cells were exposed to OIR and concurrently treated with the selected flavonoids. Cytotoxicity, oxidative stress (OS), mitochondrial content, mitochondrial membrane potential (MMP), and lipid accumulation, were once again evaluated through HCA. Subsequently, quercetin was combined with metformin (QM); insulin resistant conditions established through OIR exposure, and QM administered as prophylaxis. The efficacy of QM was determined through changes in phosphorylated-Akt, glucose uptake, and gluconeogenesis. Results: IR1 and IR2 demonstrated excessive potency, whereas OIR consistently generated insulin resistant C3A/L6 cells by increasing OS (↑14%/20%), lipid accumulation (0.7-fold/1.5-fold), and decreasing MMP (↓4%/6%). Of the selected flavonoids, quercetin was most effective at ameliorating each of these parameters. Furthermore, QM demonstrated potential insulin sensitizing synergism, as it improved Akt phosphorylation (Thr308: ↑31%/↑17%; Ser473: ↑29%), glucose uptake (↑10%/ 5%), and suppressed hepatic gluconeogenesis (15↓%) more effectively compared to monotherapy. Conclusions: OIR is an effective model for the induction of complete early-stage insulin resistance in myotubes and hepatocytes. Quercetin demonstrates exceptional antidiabetic activity due its unique expression of hydroxyl groups. Lastly, QM, comparative to monotherapy, improves insulin sensitivity with enhanced efficacy. , Thesis (Ma) -- Faculty of Health Science, 2023
- Full Text:
- Date Issued: 2023-12
- Authors: Van de Venter, Ruben
- Date: 2023-12
- Subjects: Flavonoid , Insulin resistance , Myotubes and hepatocytes
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/63049 , vital:73085
- Description: Introduction: As the third largest life-threatening non-communicable disease, further research to improve T2DM treatment remains pivotal. The approved insulin sensitizing agents, metformin and thiazolidinediones, although effective, have an array of adverse effects. This leads to the growing need for safer insulin sensitizing agents. Aims: To induce insulin resistance, an insulin resistance induction (IRI) model consisting of palmitic acid (PA), fructose, and dexamethasone (DEX), was optimized. The model was utilized to compare the insulin sensitizing efficacy of chrysin, apigenin, luteolin, and quercetin. The most effective flavonoid was extrapolated based on the hydroxylation hypothesis and relevant SAR. The flavonoid was combined with metformin to evaluate potential insulin sensitizing synergism. Methods: C3A hepatocytes and L6 myotubes were exposed to the IRI models: IR1, IR2, and OIR, for 24 and 48h. Morphological features indicative of insulin resistance were monitored through high-content analysis (HCA). Thereafter, cells were exposed to OIR and concurrently treated with the selected flavonoids. Cytotoxicity, oxidative stress (OS), mitochondrial content, mitochondrial membrane potential (MMP), and lipid accumulation, were once again evaluated through HCA. Subsequently, quercetin was combined with metformin (QM); insulin resistant conditions established through OIR exposure, and QM administered as prophylaxis. The efficacy of QM was determined through changes in phosphorylated-Akt, glucose uptake, and gluconeogenesis. Results: IR1 and IR2 demonstrated excessive potency, whereas OIR consistently generated insulin resistant C3A/L6 cells by increasing OS (↑14%/20%), lipid accumulation (0.7-fold/1.5-fold), and decreasing MMP (↓4%/6%). Of the selected flavonoids, quercetin was most effective at ameliorating each of these parameters. Furthermore, QM demonstrated potential insulin sensitizing synergism, as it improved Akt phosphorylation (Thr308: ↑31%/↑17%; Ser473: ↑29%), glucose uptake (↑10%/ 5%), and suppressed hepatic gluconeogenesis (15↓%) more effectively compared to monotherapy. Conclusions: OIR is an effective model for the induction of complete early-stage insulin resistance in myotubes and hepatocytes. Quercetin demonstrates exceptional antidiabetic activity due its unique expression of hydroxyl groups. Lastly, QM, comparative to monotherapy, improves insulin sensitivity with enhanced efficacy. , Thesis (Ma) -- Faculty of Health Science, 2023
- Full Text:
- Date Issued: 2023-12