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Status and potential of green infrastructure to support urban resilience in Zomba City, Malawi

- Likongwe, Patrick Jeremy

Authors: Likongwe, Patrick Jeremy
Date: 2023-10-13
Subjects: Uncatalogued
Language: English
Type: Academic theses , Doctoral theses , text
Identifier: http://hdl.handle.net/10962/431821 , vital:72806 , DOI 10.21504/10962/431821
Description: Small and medium towns with less than one million inhabitants are regarded to be the fastest growing urban centres globally, absorbing the bulk of the urban population growth. This urban growth drives the diminishing natural capital within the urban settings, resulting in compromised ecosystem services delivery, thereby rendering urban dwellers and systems less resilient to hazards and shocks. It is known that urban resilience discourse is rooted in robust, empirical assessments of the nature, composition and distribution of urban green infrastructure. Using the concept of green infrastructure, a mechanism for the delivery of ecosystem services that are multi-functional, well connected, and that integrate the grey-green infrastructure while providing room for social inclusion, anchored the research in a small city of Zomba, Malawi, which is a fast-growing city facing natural resource and ecosystem service degradation. The research therefore was set to understand the status of urban green infrastructure in Zomba over space and time as the basis for enhancing urban resilience. This was facilitated by an understanding of the spatial and temporal quantity, quality, diversity and distribution of urban greenspaces and the composition, structure, diversity and distributional differences of urban trees within different urban greenspace classes. Further to this was an investigation on the perceptions of and preferences for urban greenspaces among the different socio-demographic groups and finally the role of residents, institutions and institutional frameworks in building urban resilience through the delivery of ecosystem services. To achieve these objectives, the study used a suite of methods. First was geographical information system and remote sensing to understand the spatial and temporal changes in greenspaces within the city in terms of quantity and distribution. Ecological methods of assessing the tree species composition, diversity, population structure and distribution were also employed. To gauge the perceptions of and preferences for urban greenspaces, a survey was done, targeting users found within the urban greenspaces plus residents that claimed to have patronised the urban greenspaces. Finally, to understand the role of nature and the relevant urban ecosystem services provided towards building urban resilience, remote sensing and key informant interviews were done to enrich the literature searches on a case study of urban community efforts involved in managing Sadzi hill to reverse ecosystem disservices versus Chiperoni hill that was not managed. A general impression of declining urban green infrastructure was verified through the study. The city has indeed lost 14 % tree cover between 1998 and 2018 due to increased housing and creation of agricultural land to support the growing urban population. The city has 168 tree species with 65 % of them being indigenous. Residential areas were dominated by exotic trees, mainly due to the abundance of exotic fruit trees like Mangifera indica. Generally, the city has a good tree diversity score but unequally distributed, with the formal residential areas, where the colonial masters settled, having more trees than the mixed and informal residential areas. Nine urban greenspace types were identified, but there was a low per capita urban greenspace area of 11.6 m2 per person, slightly above the minimum standard set by World Health Organisation. From the preferences for and perceptions of urban greenspaces, patronage to these greenspaces (treated as parks) was highest among the educated youth, a majority being from the high housing density areas where there are no urban parks. Walking to the nearest urban greenspace took more than 10 minutes for 85 % of the respondents. With the available by-laws in support for the governance of greenspaces within the city and the role of residents towards the same, restoration efforts that targeted Sadzi hill yielded positive results through reversing ecosystem disservices that were being experienced by the community members around the hill. The community enjoys several ecosystem services that have also contributed towards building their resilience to climatic and environmental hazards. The results of this study have unveiled several green infrastructure attributes that can contribute towards building urban social ecological resilience like the presence of high proportion of indigenous tree species, healthy urban forest, high proportion of fruit trees, high diversity scores, unparalleled demand for urban greenspaces for cultural and regulatory ecosystem services, the willingness to pay and work towards managing and conserving greenspaces and the social capital available from the urban communities. However, the study also unveiled several green infrastructure related attributes that if not checked will continue to undermine efforts towards building urban resilience. These included the continued drop in tree and greenspace cover, poor governance of the available public greenspaces, unequal distribution of trees and urban greenspaces, poor management of greenspaces, bare river banks, lack of park amenities and a lack of a clear strategy, policy or an urban plan that clearly outlines green infrastructure. Efforts towards addressing these will mean acknowledging the role of green infrastructure in supporting urban social ecological resilience. , Thesis (PhD) -- Faculty of Science, Environmental Science, 2023
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Date Issued: 2023-10-13

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The adoption of international financial reporting standards and foreign direct investment inflows: the moderating effect of the institutional environment in Africa

- Simbi, Chipo

Authors: Simbi, Chipo
Date: 2023-10-13
Subjects: International Financial Reporting Standards , Investments, Foreign , Institutional infrastructure , Accounting Law and legislation , Auditing Law and legislation , Generalized method of moments , Difference in differences
Language: English
Type: Academic theses , Doctoral theses , text
Identifier: http://hdl.handle.net/10962/419230 , vital:71627 , DOI 10.21504/10962/419230
Description: Globalisation has created a need for an international accounting language to facilitate the smooth flow of trade across countries. In 2003, in an effort to establish a global financial reporting language, the International Accounting Standards Board (IASB) developed a single set of high-quality accounting principles known as the International Financial Reporting Standards (IFRS). Over the last decade, several African countries have adopted IFRS, and Africa has become the second-largest adopting continent after Europe. IFRS promotes improved quality of disclosure of accounting transactions, reduces information asymmetry between preparers and users of financial information, lowers the cost of investing, and breaks down information barriers to cross-border investment. Researchers suggest many benefits of IFRS adoption for macroeconomic indicators such as Foreign Direct Investment (FDI). The reduction in information acquisition and processing costs which translates into the reduction in investment costs, has been cited by most researchers. Researchers have argued, however, that the economic benefits of IFRS in Africa depend on the strength of the institutional environment. They also argue that the Western environment in which the IFRS was developed differs from the African environment. Thus, the universal approach of the IASB may not be appropriate due to the historical, social, economic and political context of African countries. The impact of the adoption of IFRS by African countries requires further examination, particularly as a weak institutional environment confronts many African countries. Three research questions are designed for this study; (1) Is there a significant change in FDI inflows for IFRS adopters in selected African countries after the adoption? (2) Is there a significant change in FDI inflows due to the institutional environment? (3) Does the institutional environment in IFRS-adopting countries moderate the effect of IFRS on FDI in selected African countries? The present study is underpinned by the new institutional theory, the information asymmetry theory, the eclectic theory and the signalling theory, each of which provide reasons why African countries have adopted IFRS. Nine hypotheses are developed, based on the research questions, and tested using the Systems General Method of Moments and the Difference-in-Difference method. The study uses data from 26 African countries, 15 adopting and 11 non-adopting countries, over the period 1996 - 2018. First, the study establishes that the adoption of IFRS positively and significantly affects FDI inflows into the selected sample of African countries. Second, the study concludes that legal enforcement, accounting and auditing standards enforcement, and language origin positively and significantly impact FDI inflows into these countries. Legal origin, however, has a positive but insignificant association with FDI inflows. Third, legal enforcement, historical ties, accounting and auditing enforcement and the quality of the institutional environment are found to moderate the effect of IFRS adoption on FDI inflows. These results indicate that IFRS is a crucial determinant of FDI inflows into African countries, but a supportive institutional environment is needed for African countries to attract FDI inflows after adoption. The results contribute to the accounting and finance literature on FDI into African countries, and may assist the investment community to assess the institutional risk associated with investing in IFRS adopting African countries. , Thesis (PhD) -- Faculty of Commerce, Accounting, 2023
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Date Issued: 2023-10-13

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The electrocatalytic activity of metallophthalocyanines and their conjugates with carbon nanomaterials and metal tungstate nanoparticles

- Ndebele, Nobuhle

Authors: Ndebele, Nobuhle
Date: 2023-10-13
Subjects: Uncatalogued
Language: English
Type: Academic theses , Doctoral theses , text
Identifier: http://hdl.handle.net/10962/431934 , vital:72816 , DOI 10.21504/10962/431933
Description: In this dissertation, seventeen phthalocyanine complexes were synthesised. Of these, only four are known and have been published. These complexes were synthesised using the conventional statistical condensation method that involves refluxing the phthalonitrile(s) (4-((1,3-bis(dimethylamino)propan-2-yl)oxy)phthalonitrile, 4-(4-carboxyphenoxy)phthalonitrile, 4-(4-acetylphenoxy)phthalonitrile, dimethyl 5-(3,4-dicyanophenoxy)-isophthalate, 4-(4-(tert-butyl)phenoxy)phthalonitrile, 5-phenoxylpicolinic acid phthalonitrile 4-(4-formylphenoxy) phthalonitrile, and 4-(4-(3-oxo-3-phenylprop-1-enyl) phenoxy) phthalonitrile) with the metal salt and 1,8-diazabicyclo[5.4.0]undecane as a catalyst in a high-temperature solvent. And thereafter (when necessary), isolation and purification of the target compounds were achieved through the use of silica column chromatography. These compounds were characterised using various analytical techniques such as; ultraviolet-visible absorption, mass spectroscopy, and Fourier transform infrared spectra and elemental analysis. These techniques proved that the complexes were successfully synthesised and isolated as pure compounds. Carbon-based (graphene quantum dots and nitrogen-doped graphene quantum dots) and metal oxide (bismuth tungsten oxide and nickel tungsten oxide) nanomaterials were synthesised. Together with the purchased single-walled carbon nanotubes, these nanomaterials were conjugated to some of the MPc complexes via non-covalent (carbon-based nanomaterials) and covalent (metal oxides) linkage forming hybrid materials. These nanomaterials and hybrids were characterised using various analytical methods (ultraviolet-visible absorption, X-ray diffraction, Raman spectroscopy, thermographic analysis, and dynamic light scattering). Nanomaterials were utilised herein to determine their effect on the properties of MPc complexes and provide a synergistic effect in the hope of enhancing these properties. All complexes synthesised in this work (MPcs, nanomaterials and hybrids) were employed as electrocatalysts in electrochemical sensing. These electrocatalysts were embedded onto the glassy carbon electrode via an adsorption method known as drop-casting. The modified electrode surfaces were characterised using cyclic voltammetry, electrochemical impedance spectroscopy and scanning electrochemical microscopy to determine various electrochemical parameters. These electrocatalysts were used in the detection of either nitrite, catechol and/or dopamine. The detection limits, sensitivities, kinetics and catalytic constants were among other parameters determined for each electrocatalyst. These electrocatalysts proved to be stable electrocatalysts that could potentially be used for practical applications. The determined parameters were comparable and sometimes better than those obtained in literature. , Thesis (PhD) -- Faculty of Science, Chemistry, 2023
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Date Issued: 2023-10-13

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The heterologous expression and in vitro biochemical characterization of the Hsp70 escort protein 1 and mitochondrial Hsp70 partner proteins of the Trypanosoma brucei parasite and humans

- Mahlalela, Maduma Ernst

Authors: Mahlalela, Maduma Ernst
Date: 2023-10-13
Subjects: Uncatalogued
Language: English
Type: Academic theses , Doctoral theses , text
Identifier: http://hdl.handle.net/10962/431832 , vital:72807 , DOI 10.21504/10962/431832
Description: The 70 kDa family of heat shock proteins (Hsp70) plays a central role in the maintenance of cellular proteostasis, with paralogues occurring in all the major compartments of the eukaryotic cell. Hsp70s act in conjunction with proteins known as co-chaperones, as part of the larger molecular chaperone network. In the mitochondrion, Hsp70 (mtHsp70) is responsible for the import of proteins synthesized in the cytosol, protein folding in the matrix and the maintenance of the iron-sulphur cluster. In human cells mtHsp70 (HSPA9) is also referred to as mortalin, as the knockdown of the protein leads to cell mortality. Trypanosoma brucei is the causative agent of sleeping sickness in humans and nagana in animals. In the T. brucei parasite there are three identical mtHsp70 (TbmtHsp70) proteins that are produced, forming part of the Hsp70 machinery that is essential for parasite survival. In humans, the levels of HSPA9 are often elevated in non-communicable diseases such as cancer and neurodegeneration. Despite their vital cellular roles, mtHsp70s are characteristically prone to self-aggregation. The binding of the Hsp70 escort protein (Hep1) is required to prevent the aggregation of mtHsp70 proteins, enabling the proteins to function. In many non-communicable diseases, mtHsp70 and other molecular chaperones such as heat shock protein 90 (Hsp90) are being investigated as potential drug targets. Existing anti-trypanosomal drugs for treating sleeping sickness are toxic, having adverse side effects that are potentially lethal. Investigations into Hsp70s, and other molecular chaperones, form part of the research into the discovery of novel and efficacious therapeutics. This is the first study to characterise Hep1 and investigate its partnership with mtHsp70 in T. brucei. The overall aim of this study was to comparatively assess the T. brucei and human mtHsp70/Hep1 partnerships. The putative T. brucei Hep1 (TbHep1) orthologue was analysed in silico, and it was found to possess a zinc finger domain consisting of anti-parallel β-sheets that are characteristic of canonical Hep1 proteins, whilst the N-terminal domain was unstructured. Based on sequence analysis, the regions outside of the zinc finger domains lacked conservation. Despite the lack of sequence conservation, the N- and C-terminal regions of TbHep1 shared segments of similarity with Hep1 orthologues of other kinetoplastid and trypanosomal orthologues. The same held true for the N- and C-termini of human Hep1 (HsHep1) when compared to other Hep1 orthologues of mammalian origin. Biochemical analysis revealed TbmtHsp70 and HSPA9 to be prone to self-aggregation, which was reduced by co-expression with TbHep1 and HsHep1, respectively. Recently Hep1 proteins have been determined to be present in the cytosol. In this study, TbHep1 and HsHep1 also interacted with the cytosolic Hsp70s, HSPA1A and TbHsp70, by preventing their thermally induced aggregation and stimulating their ATPase activities. TbHep1 and HsHep1 also suppressed the thermally induced aggregation of the model substrates malate dehydrogenase and citrate synthase, independently of Hsp70. To date, only two Hep1 orthologues, HsHep1 and LbHep1, have been found to function in a similar manner to a J-protein co-chaperone by stimulating the ATPase activities of their partner mtHsp70 proteins. In this study, TbHep1 stimulated the ATPase activity of TbmtHsp70. HsHep1 also stimulated the ATPase activity of TbmtHsp70. However, the mechanism of action still needs to be determined. This study also explored the potential of the Hep1 orthologues to be functionally activated by oxidative stress, which is prevalent in mitochondria. The abilities of TbHep1 and HsHep1 to reduce the thermally induced aggregation of malate dehydrogenase were enhanced under oxidative conditions. Disrupting the function of Hep1 has been found to eventually lead to cell death, and given the critical role played by mtHsp70 in the cell, this partnership could be exploited as a potential drug target. In conclusion, this study demonstrated that TbHep1 and HsHep1 functionally interact with mtHsp70s, whilst also possessing independent chaperone activities that are also potentially influenced by the environmental redox state. , Thesis (PhD) -- Faculty of Science, Biotechnology Innovation Centre, 2023
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Date Issued: 2023-10-13

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The use of dynamic software to potentially enhance conceptual understanding and a productive disposition in the visual learning of algebra: an interventionist case study

- Junius, Daniel Franscius

Authors: Junius, Daniel Franscius
Date: 2023-10-13
Subjects: Uncatalogued
Language: English
Type: Academic theses , Doctoral theses , text
Identifier: http://hdl.handle.net/10962/431542 , vital:72784 , DOI 10.21504/10962/431542
Description: Over the decades, the didactics and practice of teaching mathematics has offered many unique challenges and opportunities for exploration and understanding. The introduction and development of technology into mathematics is one of the occurrences which has also contributed to a new discourse in teaching mathematics – in this case the teaching of algebra. Algebra is still seen as a gatekeeper and remains as one of the key reasons for a negative disposition amongst learners towards learning the subject. Across the globe psychologists, philosophers and educators continue to engage in debates and research projects in search of answers and solutions for the improvement of algebra teaching and an improvement in dispositions towards learning algebra. This thesis reports on a research project that focused on the use of dynamic software to enhance the conceptual understanding and productive dispositions of selected learners through the visual learning of abstract algebraic concepts. The research was executed as an interventionist case study. A case study methodological strategy was adopted with two groups of 30 Grade 9 learners. One group was a Grade 9 mathematics class of a school in Windhoek who scored above average in algebra but showed a very low disposition score, while the other group was made up of learners from a community project who scored high on the disposition scale but achieved below average results in algebra. The analytical framework of the case study is structured around a combination of complementary algebraic topics presented through visual learning, with GeoGebra as a medium of instruction. With the focus on visualisation and the use of technology the study investigated and attempted to understand how participants processed and internalised algebraic concepts to make sense of abstract algebraic concepts and eventually gain sustained conceptual understanding. The study was framed by the theoretical theories of constructivism and the Dual Coding Theory. For the collection of data, a mixed methods approach was adopted following three cycles. Three algebraic topics were taught with GeoGebra applets yielding both qualitative and quantitative data, through the observation of participants, screen captures and reflective interviews, using instruments designed specifically for the study and collecting quantitative achievement test results. The study, a journey that both the participants and the researcher embarked upon, revealed that the use of technology enhanced conceptual understanding for both groups and both groups showed a positive change in disposition towards learning algebra. The intervention with GeoGebra consistently and progressively improved in terms of conceptual understanding and dispositions towards learning algebra significant improvements in results were achieved. The findings showed that this approach to teaching algebra yielded positive results and gave new insights into visual teaching with technology. New opportunities for further research were created. , Thesis (PhD) -- Faculty of Education, Secondary and Post-School Education, 2023
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Date Issued: 2023-10-13

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Towards a better understanding of small-scale fishing decisions and their consequences in Northern Mozambique

- Heckendorn, Katrina Ann

Authors: Heckendorn, Katrina Ann
Date: 2023-10-13
Subjects: Uncatalogued
Language: English
Type: Academic theses , Doctoral theses , text
Identifier: http://hdl.handle.net/10962/431797 , vital:72805 , DOI 10.21504/10962/431797
Description: This study investigates the relationship between the interacting social and ecological systems within the Pemba Bay fishery, in Northern Mozambique, as mediated by fishing decisions. All ecosystems in the world are affected by human behaviours in some way. In many cases, human effects on ecosystems are detrimental to many other species and can cause shifts in the entire system. In fisheries, the connections between human behaviours and ecosystems are obvious, as fishers extract wild populations of marine species. Human behavioural plasticity and sometimes rapid cultural evolution allow human behaviours to change and adapt faster than many other species can respond which often allows fishers to overexploit marine ecosystems. Many fisheries in the world are fully, or over exploited. Managing these fisheries often focuses on changing those highly adaptable human behaviours. Fishers’ motivations for making different fishing decisions as well as attitudes towards the fishery can be used to understand human interactions with ecosystems when the dependence between the two is direct, as well as allowing managers to tailor interventions that account for fishers’ motivations and attitudes. Most fisheries’ management projects assume that behaviours are motivated by profit maximization. This study investigates this assumption by comparing the compatibility of interview responses and fishing behaviours with rational actor theory, which assumes profit maximization is the only goal. Responses are also compared with prospect theory, which emphasizes reliability of outcomes; descriptive norms, which focuses on social interactions; habitual behaviour, which assumes most decision are automatic based on habit; and theory of planned behaviour, which allows attitudes to be shaped by economic or non-economic motivations, as well as peer opinion and incorporates perceived behavioural control in making decisions. These behavioural theories span a variety of potential fisher motivations which could affect fishing decisions. The study then investigates the state of the social and ecological systems which have resulted, at least in part, from those fishing decisions, and makes recommendations on possible interventions to improve the system based on better understanding of fishers’ attitudes and motivations. The study tests the hypothesis that fishers are motivated primarily by profit maximization and, therefore, rational actor theory is most compatible with fishers’ stated motivations for fishing, or alternatively, that one of the other behavioural theories better explains fisher responses. This section used categorized interview responses based on their agreement, or not, with assumed responses if a particular behavioural theory were compatible. The results indicate that four of the five theories are most compatible with responses for at least one fisher, but that the theory of planned behaviour is the most consistent with the data overall, not rational actor theory. Specifically, fishers seem concerned with behavioural control as well as some non-catch related characteristics of the fishery, such as collective action and sustainability. The second hypothesis is that prospect theory is more compatible with current fishing behaviours than rational actor theory. Prospect theory states that people prefer more reliable outcomes, even if slightly less profitable, than outcomes which are more profitable on average, but also more variable. This section used catch data, and changes in relative use of different fishing methods to address this hypothesis. This hypothesis is confirmed for some aspects of fishery data, but not all. Fishers prefer methods which are more reliable and these methods are increasing in relative use. However, neither catch value nor reliability increases fishers’ opinions of their fishing method, but fisher characteristics which increase options do. This again indicates that behavioural control is important in determining fishers’ attitudes towards fishing. The third question addresses the social system within the fishery. It investigates whether fishing in Pemba Bay is a chosen profession or a livelihood of desperation from the poorest individuals. The study hypothesizes that fishers are as well-off as their non-fishing neighbours, and fishers who use more reliable or profitable methods are better off than those using less reliable/profitable methods and, as such, are more committed to fishing as a way of life. This section used fisher interview responses and household surveys to compare subjective and material wellbeing of fishers and non-fishers around Pemba Bay. The first part of the hypothesis is partly supported. Fishers using most methods have material standards of living comparable to non-fishers. However, they report lower subjective well-beings. Most measures of wellbeing are not affected by the reliability or profitability of the fishing method used, which does not support the second part of the hypothesis. Additionally, fishers using more profitable or reliable methods do not indicate more commitment to fishing as a way of life. The fourth and final section investigates the marine ecosystem. Based on conversations with fishers and local researchers, it is assumed that the Pemba fishery is overexploited. As such, the study hypothesizes that marine biomass, individual size of marine species, and functional diversity are lower in Pemba Bay than in other sites around Northern Mozambique, Vamizi Island, Situ Island, and Nuarro, due to high fishing pressure, and that direct removal of species by fishing has a dominant effect. This final section used baited remote underwater videos (BRUVs) to compare species composition and indices of abundance from the different locations. Again, there is support for part of this hypothesis. Marine species biomass and sizes are lower in Pemba Bay than other sites in Northern Mozambique; however, functional diversity is not different. In these data, changes in biomass and size are not correlated with amount of catch, so direct removal by fishing may not be the dominant source of change in the Pemba fishery. Together, these data indicate that the Pemba fishery may be unsustainable based on social and ecological indications. The importance of behavioural control in understanding fishing decisions indicates that any interventions to mitigate problems in the fishery will need to work with fishers to increase empowerment and allow experimentation to find locally relevant solutions to problems. , Thesis (PhD) -- Faculty of Science, Ichthyology and Fisheries Science, 2023
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Date Issued: 2023-10-13

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With dreams in our hands: Towards transgressive knowledge-making cultures

- Knowles, Corinne Ruth

Authors: Knowles, Corinne Ruth
Date: 2023-10-13
Subjects: African feminism , Pedagogy , Political sociology , Knowledge, Theory of Political aspects , Transformative learning
Language: English
Type: Academic theses , Doctoral theses , text
Identifier: http://hdl.handle.net/10962/402955 , vital:69909 , DOI 10.21504/10962/402955
Description: Knowledge-making in universities is not neutral and takes different forms. This thesis critically examines the politics of knowledge to propose and present a transgressive schema for knowledge-making that is co-created with students. It emerges from teaching and learning encounters in the Humanities Extended Studies (ES) Programme at Rhodes University, where for the past decade we have experimented with different ways of knowledge-making that run counter to conventional pedagogic practices. We set up a project for the thesis that allowed us to work with knowledge in ways that are Afrocentric, and that hold and nurture our dreams. The theory and methodology of the project are explained in the first academic paper for this PhD by publication. The project and its derivatives use an African Feminist framing, and centre the ontoepistemologies of African young people who find themselves alienated and marginalised by a western bias in university curricula. Former ES student volunteers came up with topics, responded to them, reviewed each other’s work, and co-wrote two academic papers that demonstrate a praxis of African Feminist research and pedagogic principles. Two further projects practise the principles that emerge from the primary project, and together they have tested knowledge-making cultures that inspire critical thinking and creative humanity. These are explained in two further academic papers. One is co-written with the copresenter of an online inter-continental short course for PhD students on African Feminist Research Methodology. The other is single authored, and introduces the third project, a Political and International Studies third-year course on African Feminist theory. The schema for knowledge-making uses the hand, which holds our dream, as a descriptive metaphor. Each of the five fingers of the hand represents an aspect of how we have collaborated on the projects and in lecture rooms, and what this has taught us about how to nurture and inspire the dreams of young African people through transgressive knowledgemaking cultures. The five aspects – framing, activating, seeing, creating, imagining – are mutually constitutive elements of knowledge-making that are introduced throughout the thesis, and explained in careful detail in the conclusion as a synthesis of the collaborations. , Siphethe amaphupha ezandleni zethu: ukwenza iinckubeko zolwazi ezigxile ekuphazamiseni isiqhelo Isishwankathelo Ukwenziwa kolwazi kwiiunivesithi asiyonto engathathi cala kwaye yenzeka ngeendlelangeendlela. Le thisisi iphonononga ipolitiki yolwazi ngenjongo yokucebisa nokuvelisa iindlela zokwenziwa kolwazi ezigxile ekuphazamiseni kwesiqhelo, ndlela leyo eyenziwa ngentsebenziswano nabafundi. Le Ndlela yokuphazamisa isiqhelo ivela kwindlela zokufunda nokufundisa kwinkqubo yeExtended Studies kwiUnivesithi iRhodes, apho kwiminyaka elishumi edlulileyo besisebenzisa amalinge ohlukileyo okwenza ulwazi ohlukileyo kwindlela zokufunda eziqhelekileyo. Siqulunqe inkqubo yale thisisi evumele ukuba sisebenze nolwazi ngendlela ekhokhelelisa ubuAfrika phambile, nkqubo leyo eyondla nebamba amaphupha ethu. Inkcazo-bungcali neendlela zokwenza uphando lwalo msebenzi zicacisiwe kwiphepha lokuqala lethisisi yePhD ezakupapashwa. Lo msebenzi neminye imisebenzi efana nawo isebenzisa iAfrikan Feminism ngenjongo yokubeka ngokusesikweni ndlela le ingxile kwindlela yokufundisa neengcambu zayo ezizinze eAfrika, kwaye ikhokhelisa imfundo yabantu abatsha abazifumana besenziwe amakheswa nabahlelelekileyo kunyenjwa kwasentshona kwizifundo zaseunivesithi. Abafundi ababefunda kwiES baze nezihloko, yangabo abaziphendulayo, bahlola imisebenzi yoogxa babo, kwaye bancedisa ekubhaleni amaphepha amabini abonakalisa indlela yokuphanda kusetyenziswa iziseko zokufunda zeAfrikan Feminism. Eminye imisebenzi isebenzise iziseko eziphuma kulo msebenzi wokuqala, kwaye yomibini le misebenzi iphonononga iinkcubeko zokwenza ulwazi ezikhuthaza ukuzikisa ukucinga nobuntu obunobuchule. Oku kucaciswa nzulu kumaphepha amabini. Omnye ubhalwe nomfundi kunye nombhali obefundisa kwikhosi emfutshane ebikwi-intanethi ephakathi kwamazwekazi eyenzelwe abafundi be- PhD kwiAfrican Feminist Research Methodology. Omnye umsebenzi ubhalwe ngumntu omnye, nothi wazise umsebenzi wesithathu, ikhosi yonyaka wesithathu yePolitical and International Studies yenkcazo-bungcali iAfrican Feminism. Icebo lokwenza ulwazi lisebenzisa isandla esibambe amaphupha ethu, njengesafobe esinika inkcazelo. Umnwe ngamnye umele indlela esisebenzisene ngayo kule misebenzi nakumagumbi okufundela, kunye nesikufundileyo ngokukhulisa nokukhuthaza amaphupha wabantu abasebatsha baseAfrika ngokusebenzisa imisebenzi egxile kwiinkcubeko zolwazi eziphazamisa ukwenziwa kolwazi ngendlela eqhelekileyo. Imiba emihlanu- ukwenza isakhelo, ukuqalisa, ukubona, ukudala, ukusebenzisa imifanekiso ntelekelelo- iyingqokelela yenxalenye yokwenza ulwazi ngendlela enentsebenziswano kwaye ezi ziseko zaziswa banzi kwithisisi, kwaye zicaciswe gabalala kwisishwankathelo njengengqokelela yentsebenziswano kulo msebenzi. , Thesis (PhD) -- Faculty of Education, Education, 2023
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Date Issued: 2023-10-13

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An efficient approach for the synthesis of dolutegravir and its analogue exploiting flow chemistry

- Nqeketo, Sinazo

Authors: Nqeketo, Sinazo
Date: 2023-04
Subjects: HIV (Viruses) – Enzymes –Inhibitors , Antiviral agents -- South Africa
Language: English
Type: Doctoral theses , text
Identifier: http://hdl.handle.net/${Handle} , vital:70635
Description: Africa has the highest Human Immunodeficiency Virus (HIV) prevalence in the world and has invested heavily in running its HIV programmes and conducting research of medical significance. Despite efforts in combating this disease the production, distribution, cost, and availability of antiretroviral (ARV) generics remains a major problem as they are imported from China and India. Exploring the recently emerged “enabling technique”, namely flow chemistry in the production of APIs has gained a lot of attention. This study was devoted on exploring the application of flow chemistry on the synthesis of a newly approved anti-HIV drug dolutegravir (DTG); an integrase inhibitor with a high genetic barrier to resistance with a daily dosing scheduled compared to other ARVs and its third-generation inhibitor analogue, cabotegravir. Chapter one covers a comprehensive background and literature review of the HIV epidemic, an introduction of antiretroviral therapy as well as detailed dolutegravir and cabotegravir synthesis. A brief introduction of continuous flow technology with its advantages and disadvantages is discussed in this chapter. The efficient seven-step continuous flow procedure afforded dolutegravir and cabotegravir in improved reaction times and yields compared to the traditional batch procedure was demonstrated. The significant advantage of this flow process includes the reduction of the overall reaction time from step one to step seven, from prolonged 68 hours in batch to 34 minutes. The overall yield of each reaction step improved dramatically upon flow optimization. The yields of the second step (selective ester hydrolysis), fourth step (cyclization) and fifth step (amidation) increased from 64 %, 40 % and 33 % in batch to 98 %, 71 % and 100 % yield by HPLC respectively. Other than improved yields and residence times which was aided advantages of microreactor technology including intensive mixing, the flow process is also much better because it is cost effective. Most importantly, a novel process on the formation of pyridinone intermediate using ion-exchange resin catalysts towards the synthesis of dolutegravir and cabotegravir was described in this study , Thesis (PhD) -- Faculty of Science, School of Biomolecular and Chemical Science, 2023
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Date Issued: 2023-04

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An evaluation of the effectiveness of area-based conservation interventions in avoiding biodiversity loss in South Africa

- Von Staden, Lize

Authors: Von Staden, Lize
Date: 2023-04
Subjects: Environmental policy , Conservation of natural resources -- Government policy -- South Africa
Language: English
Type: Doctoral theses , text
Identifier: http://hdl.handle.net/10948/61115 , vital:69762
Description: Counterfactual impact evaluation studies form an important evidence base for the effectiveness of conservation projects, programs, and policies (collectively referred to as conservation interventions). In South Africa, counterfactual impact evaluation methods have rarely been applied to local conservation interventions, and therefore evidence for the effectiveness of key strategic national conservation approaches is lacking. This study evaluated three area-based interventions that together aim to avoid the loss of areas most important for the persistence of biodiversity in the terrestrial realm as evidence towards the effectiveness of South Africa’s landscape approach to biodiversity conservation. The first intervention, South Africa’s National Protected Area Expansion Strategy (NPAES), set ambitious targets to double the extent of South Africa’s protected area network while ensuring that the expansion preferentially occurs in areas of under-represented biodiversity. The strategy was evaluated in terms of its effectiveness in guiding protected area expansion towards more equitable representation of South Africa’s biodiversity through an assessment of changes in indicators of protected area expansion decision-making before and after the implementation of the strategy. The second intervention is the use of maps of biodiversity priorities to guide land use change decisions outside protected areas. Impact was evaluated as avoided loss of Critical Biodiversity Areas (CBAs), which need to remain in a natural condition to meet in situ conservation targets for species, ecosystems, and ecological processes. Avoided loss in CBAs was benchmarked against avoided loss in protected areas, to contextualize the effectiveness of land use planning as a conservation intervention. Lastly, the effectiveness of stricter land use regulations for threatened ecosystems to reduce land conversion pressure on these ecosystems was evaluated. Key findings were that protected areas are highly effective conservation interventions where they can be implemented, but their capacity for conservation impact is limited by severe constraints on strategic expansion. , Thesis (PhD) -- Faculty of Science, School of Environmental Sciences, 2023
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Date Issued: 2023-04

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An exploration of the Participatory Guarantee System (PGS) facilitating the growth and certification of small-scale organic farmers: Giyani, Garden Route and Overberg case studies

- Mashele,N’wa-Jama

Authors: Mashele,N’wa-Jama
Date: 2023-04
Subjects: Organic farming – Case studies --South Africa , Organic farming research
Language: English
Type: Doctoral theses , text
Identifier: http://hdl.handle.net/10948/60741 , vital:66574
Description: In this study, I evaluated the Participatory Guarantee System (PGS) as a framework to support the growth and certification of small-scale organic farmers. I used the interpretivism and constructivism lenses to understand the PGS from the perspective of members of three PGS groups. The research was qualitative, treating the three PGS groups as case studies. I collected data using focus groups, semi-structured interviews, questionnaires, field notes and observations. The theoretical frameworks that guided the research and data analysis were Socio-ecological Systems (SES) based principles and the Multi-Level-Perspective (MLP) framework. The data were analysed using Atlas.ti content analysis software. The key results were grouped into four themes: capacity; market and logistics; learning process; and disturbance, shock and stress. The theme of ‘capacity’ dealt with the functioning of a PGS, where three categories were identified: group composition and capacity; resource limitations and institutional support; marketing and consumer education. The more diversity in age, education and culture of PGS stakeholders, the better performance and chances of continuity and propagation. PGS has limited capacity partly due to its voluntary nature and infancy. It needs institutional support to grow and be useful for members. Department of Agriculture extension officers knew little about organic farming, thus limiting their engagement and assistance to such farmers. The theme of ‘market and logistics’ looked at the various factors that influence the farmers’ market reach. The perception from the members was that there was minimal consumer awareness about organic agriculture and the PGS. The marketing of organic produce relied largely on the individual farmer’s efforts and ability to search for and secure markets. The theme of the ‘learning process’ was categorised into learning and knowledge exchange. Members of the PGS groups highly regarded the invaluable knowledge shared through farm visits and online platforms, such as their WhatsApp groups. This knowledge improved and informed their farming techniques and led to the growth of v their skill base and experimentation. They viewed the way knowledge was exchanged as non-threatening and highly useful. The fourth theme of ‘disturbance, shock and stress’ dealt with the effects of COVID19. The three groups were all affected by lockdown restrictions (at the time of data collection) and were initially cut off from their usual markets. This led to a loss of income, loss of farm staff and a loss of the desired growth of the farms. The group’s diverse farming practices bolstered their resilience, enabling them to adapt and try alternative marketing strategies. , Thesis (MSc) -- Faculty of Science, School of Natural Resource Management, 2023
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Date Issued: 2023-04

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Billing system, communication strategies, and organisation change in Zimbabwe: the case of telone customers’ postpaid to prepaid migration

- Dube, Sizalobuhle

Authors: Dube, Sizalobuhle
Date: 2023-04
Subjects: Communication , Organizational change , Organizational change -- Management
Language: English
Type: Doctoral theses , text
Identifier: http://hdl.handle.net/10353/27336 , vital:66942
Description: This study investigated the effectiveness of the communication strategies used to implement the migration of telephone services from post-paid to prepaid billing at TelOne Zimbabwe. This study adopted the Freeman‟s stakeholder theory and the Lewin‟s change model to analyse the factors that influenced the effectiveness of the communication strategies used by TelOne before, during and after the change implementation as a way to communicate the initiative with its stakeholders. A qualitative approach was utilised and the key research methods used included document analysis, participant observation, as well as 21 face-to-face and 79 telephonic semi-structured interviews conducted with respondents from among TelOne managers, employees and the customers. The documents and respondents were purposively sampled based on the researcher‟s knowledge of their relevance in the study. The findings revealed several factors that mired effective change communication strategies such as company image, stakeholder recognition and communication centralisation. To curb these communication challenges, the study proposes Thrive organisational communication change model TOCC that encourages organisations to communicate the initiative to its relevant internal and external stakeholders considering their views and addressing factors that might hinder effective communication as a strategy to enhance successful change management. , Thesis (PhD) -- Faculty of Social Sciences and Humanities, 2023
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Date Issued: 2023-04

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