Synthesis, computational and biological studies of alkyltin(IV)N-methyl-N-hydroxyethyl dithiocarbamate complexes
- Date: 2021-7
- Subjects: Organotin Compounds Anti-inflammatory agents Cell-mediated Cytotoxicity Article
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/7713 , vital:54743 , ("https://doi.org/10.1016/j.heliyon.2021.e07693")
- Description: Methyltin(IV) of butyltin(IV)–N-hydroxyethyl dithiocarbamate complexes, represented as [(CH3)2Sn(L(OH))2] and [(C4H9)2Sn(L(OH))2] respectively were synthesized and characterized using spectroscopic techniques (1 H, 13C and 119Sn NMR) and elemental analysis. Both infrared and NMR data showed that, the complexes were formed via two sulphur atoms of the dithiocarbamate group. This mode of coordination was further supported by the DFT calculation, which suggested the formation of a distorted octahedral geometry around the tin atom. The complexes were screened for their antioxidant, cytotoxicity and anti-inflammatory properties. Four different assays including DPPH, nitric oxide, reducing power and hydrogen peroxides were used for the antioxidant studies, while an in vitro anti-inflammatory study was done using albumin denaturation assay. The complexes showed good antioxidant activity, especially in the DPPH assay. Butyltin(IV)–N-hydroxyethyl dithiocarbamate showed better cytotoxicity activity compared to methyltin(IV)–N-hydroxyethyl dithiocarbamate in the selected cell lines, which included KMST-6, Caco-2 and A549 cell lines. The anti-inflammatory activities revealed that the two complexes have useful activities better than diclofenac used as control drug
- Full Text:
- Date Issued: 2021-7
- Date: 2021-7
- Subjects: Organotin Compounds Anti-inflammatory agents Cell-mediated Cytotoxicity Article
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/7713 , vital:54743 , ("https://doi.org/10.1016/j.heliyon.2021.e07693")
- Description: Methyltin(IV) of butyltin(IV)–N-hydroxyethyl dithiocarbamate complexes, represented as [(CH3)2Sn(L(OH))2] and [(C4H9)2Sn(L(OH))2] respectively were synthesized and characterized using spectroscopic techniques (1 H, 13C and 119Sn NMR) and elemental analysis. Both infrared and NMR data showed that, the complexes were formed via two sulphur atoms of the dithiocarbamate group. This mode of coordination was further supported by the DFT calculation, which suggested the formation of a distorted octahedral geometry around the tin atom. The complexes were screened for their antioxidant, cytotoxicity and anti-inflammatory properties. Four different assays including DPPH, nitric oxide, reducing power and hydrogen peroxides were used for the antioxidant studies, while an in vitro anti-inflammatory study was done using albumin denaturation assay. The complexes showed good antioxidant activity, especially in the DPPH assay. Butyltin(IV)–N-hydroxyethyl dithiocarbamate showed better cytotoxicity activity compared to methyltin(IV)–N-hydroxyethyl dithiocarbamate in the selected cell lines, which included KMST-6, Caco-2 and A549 cell lines. The anti-inflammatory activities revealed that the two complexes have useful activities better than diclofenac used as control drug
- Full Text:
- Date Issued: 2021-7
Covid-19 and the restrictive measures: The national security conundrum for Zimbabwe
- Mugari, Ishmael, Obioha, Emeka E.
- Authors: Mugari, Ishmael , Obioha, Emeka E.
- Date: 2021
- Subjects: COVID-19 (Disease) National security Article
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6926 , vital:52571 , xlink:href="https://10.1080/10246029.2021.1972015"
- Description: The emergence of the COVID-19 pandemic at the onset of the year 2020 brought unprecedented suffering to humanity. Economic activities in virtually all nations across the globe were brought to a shuddering halt, with the third world suffering the worst effects on the economic front. The health security of nations across the globe was shaken, as nations came to terms with the surging health needs for the infected citizens. In order to grapple with the pandemic, nations took drastic measures, chief among them being the implementation of lockdowns, coupled with harsh restrictions. These measures, however, came at a cost. This paper explores the impacts of the restrictive measures that were implemented by the Zimbabwean government to combat COVID-19 pandemic. The paper interrogates these measures in the context of the national security discourse. In the analysis, the paper also makes reference to South Africa- a more developed nation and Zimbabwe’s neighbour. Keywords: COVID-19 , national security, health security, lockdown
- Full Text:
- Date Issued: 2021
- Authors: Mugari, Ishmael , Obioha, Emeka E.
- Date: 2021
- Subjects: COVID-19 (Disease) National security Article
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6926 , vital:52571 , xlink:href="https://10.1080/10246029.2021.1972015"
- Description: The emergence of the COVID-19 pandemic at the onset of the year 2020 brought unprecedented suffering to humanity. Economic activities in virtually all nations across the globe were brought to a shuddering halt, with the third world suffering the worst effects on the economic front. The health security of nations across the globe was shaken, as nations came to terms with the surging health needs for the infected citizens. In order to grapple with the pandemic, nations took drastic measures, chief among them being the implementation of lockdowns, coupled with harsh restrictions. These measures, however, came at a cost. This paper explores the impacts of the restrictive measures that were implemented by the Zimbabwean government to combat COVID-19 pandemic. The paper interrogates these measures in the context of the national security discourse. In the analysis, the paper also makes reference to South Africa- a more developed nation and Zimbabwe’s neighbour. Keywords: COVID-19 , national security, health security, lockdown
- Full Text:
- Date Issued: 2021
Mildly elevated thyroid-stimulating hormone is associated with endothelial dysfunction and severe preeclampsia among pregnant women with insufficient iodine intake in Eastern Cape province, South Africa
- Businge, Charles Bitamazire, Longo-Mbenza, Benjamin, Kengne, Andre Pascal
- Authors: Businge, Charles Bitamazire , Longo-Mbenza, Benjamin , Kengne, Andre Pascal
- Date: 2021
- Subjects: Preeclampsia Iodine deficiency diseases Endothelial cells Article
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6908 , vital:52565 , xlink:href="https://10.1080/07853890.2021.1947520"
- Description: Background Preeclampsia and hypothyroidism are associated with endothelial dysfunction. Iodine deficiency is a risk factor for subclinical hypothyroidism in pregnancy. However, there is a paucity of data on the relationship between iodine nutrition state in pregnancy, the degree of endothelial dysfunction, and the risk of preeclampsia. Methods Ninety-five normotensive pregnant women, 50 women with preeclampsia with no severe features, and 50 women with severe preeclampsia were enrolled into the current study from the maternity units of Nelson Mandela Academic Hospital and Mthatha Regional Hospitals in Eastern Cape Province, South Africa. Urinary iodine concentration (UIC), serum markers of thyroid function, aortic augmentation index, and pulse wave velocity (PWV) were compared. Results Median UIC was 167.5, 127.7, and 88.5 µg/L, respectively for normotensive pregnant women, those with preeclampsia and severe preeclampsia (p = .150). Participants with severe preeclampsia had significantly higher median thyroid-stimulating hormone (TSH) and oxidized LDL than normotensive and preeclamptic women without severe features (respectively 3.0, 2.3, and 2.3 IU/L; 1.2, 1.0, and 1.0 IU/L, p less .05). The median Aortic augmentation index was 7.5, 19.0, and 21.0 (p less .001), and the pulse wave velocity 5.1, 5.7, and 6.3, respectively for normotensive, preeclampsia, and severe preeclampsia participants (both p less .001). In linear regressions, TSH, age, and hypertensive disease were independent predictors of elevated PWV. Conclusion Upper normal-range TSH levels in women with severe preeclampsia were associated with markers of endothelial dysfunction. The low UIC and trend towards the elevation of thyroglobulin suggest that inadequate iodine intake may have increased TSH levels and indirectly caused endothelial dysfunction. Keywords: Preeclampsia, Iodine deficiency, Elevated thyroid-stimulating hormone, Pulse wave velocity, Endothelial dysfunction
- Full Text:
- Date Issued: 2021
- Authors: Businge, Charles Bitamazire , Longo-Mbenza, Benjamin , Kengne, Andre Pascal
- Date: 2021
- Subjects: Preeclampsia Iodine deficiency diseases Endothelial cells Article
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6908 , vital:52565 , xlink:href="https://10.1080/07853890.2021.1947520"
- Description: Background Preeclampsia and hypothyroidism are associated with endothelial dysfunction. Iodine deficiency is a risk factor for subclinical hypothyroidism in pregnancy. However, there is a paucity of data on the relationship between iodine nutrition state in pregnancy, the degree of endothelial dysfunction, and the risk of preeclampsia. Methods Ninety-five normotensive pregnant women, 50 women with preeclampsia with no severe features, and 50 women with severe preeclampsia were enrolled into the current study from the maternity units of Nelson Mandela Academic Hospital and Mthatha Regional Hospitals in Eastern Cape Province, South Africa. Urinary iodine concentration (UIC), serum markers of thyroid function, aortic augmentation index, and pulse wave velocity (PWV) were compared. Results Median UIC was 167.5, 127.7, and 88.5 µg/L, respectively for normotensive pregnant women, those with preeclampsia and severe preeclampsia (p = .150). Participants with severe preeclampsia had significantly higher median thyroid-stimulating hormone (TSH) and oxidized LDL than normotensive and preeclamptic women without severe features (respectively 3.0, 2.3, and 2.3 IU/L; 1.2, 1.0, and 1.0 IU/L, p less .05). The median Aortic augmentation index was 7.5, 19.0, and 21.0 (p less .001), and the pulse wave velocity 5.1, 5.7, and 6.3, respectively for normotensive, preeclampsia, and severe preeclampsia participants (both p less .001). In linear regressions, TSH, age, and hypertensive disease were independent predictors of elevated PWV. Conclusion Upper normal-range TSH levels in women with severe preeclampsia were associated with markers of endothelial dysfunction. The low UIC and trend towards the elevation of thyroglobulin suggest that inadequate iodine intake may have increased TSH levels and indirectly caused endothelial dysfunction. Keywords: Preeclampsia, Iodine deficiency, Elevated thyroid-stimulating hormone, Pulse wave velocity, Endothelial dysfunction
- Full Text:
- Date Issued: 2021
- «
- ‹
- 1
- ›
- »