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Biopharmaceutics of phenylpropanolamine

- Dowse, Roslind

  • Authors: Dowse, Roslind
  • Date: 1984
  • Subjects: Biopharmaceutics Pharmacokinetics Phenylpropanolamine Pharmacology High performance liquid chromatography
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:3818 , http://hdl.handle.net/10962/d1004915
  • Description: Phenylpropanolamine (PPA), a sympathomimetic amine, has been widely used over the past 40 years as a decongestant and, in much larger dosages, as an appetite suppressant. Considerable interest has recently been shown in this drug due to its increasing popularity as an over-the-counter anorectic agent. Much controversy exists concerning the unfavourable side-effects of PPA resulting from the higher doses required for appetite suppression and the potential of this drug for abuse. A literature search revealed a paucity of information concerning the determination of PPA in biological fluids and, most noticeably, on the pharmacokinetics of this drug. An original method for determining PPA in serum and urine using high performance liquid chromatography (HPLC) which has increased sensitivity over other published HPLC methods is presented here. The simplicity of the extraction from biological fluids and subsequent determination by HPLC, enables concentrations of PPA to be monitored after a single dose of the drug. This method is therefore readily applicable to bioavailability and pharmacokinetic studies. The dissolution profiles of 4 sustained-release formulations of PPA were determined in a modified USP rotating paddle apparatus and the samples analysed using HPLC. A mathematical equation was applied to these data which are expressed in terms of dissolution parameters. Oral test dosage forms and solutions of PPA were investigated in bioavailability trials using the developed HPLC method to analyse the urine and serum samples. Linear one body compartment kinetics were assumed and the WagnerNelson method used to transform in vivo serum data to absorption plots which were then fitted to the well known Weibull equation. In order to more appropriately characterize the kinetic processes of absorption, distribution and elimination, a more complex model was utilized which involved numerical integration of a series of differential equations. The data were fitted to these models using nonlinear regression techniques. The pharmacokinetics of PPA are shown to exhibit some evidence of nonlinearity. The absorption of the drug appears to be di scontinuous and PPA seems to favour a two body compartment model.
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  • Date Issued: 1984

Black Workers housing 1984

  • Date: 1984
  • Subjects: Rhodes University -- History , Rhodes University -- Employees , Rhodes University -- Employees -- Housing
  • Type: Image
  • Identifier: http://hdl.handle.net/10962/39570 , vital:24899 , PIC/M 5508 , This image is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
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  • Date Issued: 1984

Black Workers housing 1984

  • Date: 1984
  • Subjects: Rhodes University -- History , Rhodes University -- Employees , Rhodes University -- Employees -- Housing
  • Type: Image
  • Identifier: http://hdl.handle.net/10962/39501 , vital:24891 , PIC/M 5505 , This image is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
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  • Date Issued: 1984

Black Workers housing 1984

  • Date: 1984
  • Subjects: Rhodes University -- History , Rhodes University -- Employees , Rhodes University -- Employees -- Housing
  • Type: Image
  • Identifier: http://hdl.handle.net/10962/39522 , vital:24893 , PIC/M 5506 , This image is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
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  • Date Issued: 1984

Black Workers housing 1984

  • Date: 1984
  • Subjects: Rhodes University -- History , Rhodes University -- Employees , Rhodes University -- Employees -- Housing
  • Type: Image
  • Identifier: http://hdl.handle.net/10962/39591 , vital:24900 , PIC/M 5504 , This image is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
  • Full Text: false
  • Date Issued: 1984

Black Workers housing 1984

  • Date: 1984
  • Subjects: Rhodes University -- History , Rhodes University -- Employees , Rhodes University -- Employees -- Housing
  • Type: Image
  • Identifier: http://hdl.handle.net/10962/39552 , vital:24896 , PIC/M 5507 , This image is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
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  • Date Issued: 1984

Black workers' stay away

  • Date: 1984
  • Subjects: Rhodes University -- History , Rhodes University -- Employees , Rhodes University -- Employees -- Housing
  • Type: Image
  • Identifier: http://hdl.handle.net/10962/39611 , vital:24902 , PIC/M 5509 , This image is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
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  • Date Issued: 1984

Black Zenzele housing

  • Date: 1984
  • Subjects: Rhodes University -- History , Rhodes University -- Employees , Rhodes University -- Employees -- Housing
  • Type: Image
  • Identifier: http://hdl.handle.net/10962/39621 , vital:24903 , PIC/M 5510 , This image is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
  • Full Text: false
  • Date Issued: 1984

Black Zenzele housing

  • Date: 1984
  • Subjects: Rhodes University -- History , Rhodes University -- Employees , Rhodes University -- Employees -- Housing
  • Type: Image
  • Identifier: http://hdl.handle.net/10962/39643 , vital:24906 , PIC/M 5511 , This image is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
  • Full Text: false
  • Date Issued: 1984

Black Zenzele housing

  • Date: 1984
  • Subjects: Rhodes University -- History , Rhodes University -- Employees , Rhodes University -- Employees -- Housing
  • Type: Image
  • Identifier: http://hdl.handle.net/10962/40235 , vital:24963 , PIC/M 5513 , This image is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
  • Full Text: false
  • Date Issued: 1984

Black Zenzele housing

  • Date: 1984
  • Subjects: Rhodes University -- History , Rhodes University -- Employees , Rhodes University -- Employees -- Housing
  • Type: Image
  • Identifier: http://hdl.handle.net/10962/39653 , vital:24907 , PIC/M 5512 , This image is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
  • Full Text: false
  • Date Issued: 1984

Bongani Nkosi

- Maryville Centre workshop participants, Dargie, Dave

Bongani Nkosi

- Maryville Centre workshop participants, Dargie, Dave

Bonke Bazaliswa

- St Patricks' Church Choir, Nyakanyaka, D., Dargie, Dave

Bonke Bazaliswa

- St Patricks' Church Choir, Nyakanyaka, D., Dargie, Dave

Book Review Alone, Alone

- Berold, Robert

  • Authors: Berold, Robert
  • Date: 1984
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/460206 , vital:75906 , https://journals.co.za/doi/epdf/10.10520/AJA00284459_445
  • Description: New Coin is one of South Africa's most established and influential poetry journals. It publishes poetry, and poetry-related reviews, commentary and interviews. New Coin places a particular emphasis on evolving forms and experimental use of the English language in poetry in the South African context. In this sense it has traced the most exciting trends and currents in contemporary poetry in South Africa for a decade of more. The journal is published twice a year in June and December by the Institute for the Study of English in Africa (ISEA), Rhodes University.
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  • Date Issued: 1984

Book Review: Seductive Signifiers

- Cornwell, Gareth D N

  • Authors: Cornwell, Gareth D N
  • Date: 1984
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/460168 , vital:75897 , https://journals.co.za/doi/epdf/10.10520/AJA00284459_407
  • Description: New Coin is one of South Africa's most established and influential poetry journals. It publishes poetry, and poetry-related reviews, commentary and interviews. New Coin places a particular emphasis on evolving forms and experimental use of the English language in poetry in the South African context. In this sense it has traced the most exciting trends and currents in contemporary poetry in South Africa for a decade of more. The journal is published twice a year in June and December by the Institute for the Study of English in Africa (ISEA), Rhodes University.
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  • Date Issued: 1984

Calibration and interpretation of A 2.3 GHz continuum survey

- Greybe, Andrew

  • Authors: Greybe, Andrew
  • Date: 1984
  • Subjects: Radio astronomy , Astronomical observatories , Galaxies
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:5502 , http://hdl.handle.net/10962/d1007210 , Radio astronomy , Astronomical observatories , Galaxies
  • Description: This thesis continues the Rhodes 2.3 GHz Survey of the Southern Sky. It consists of two parts : a data processing part and an astronomical analysis part. In the data processing part the data for the regions 4HR to 15HR, -80° to -61° and 12HR to 23HR . -27° to -7° are presented in contour map format. A beam pattern of the Hartebeesthoek telescope at 13 cm is constructed from drift scans of the radio source TAU A. This is used to investigate the data filtering techniques applied to the Rhodes Survey. It is proposed that a set of widely spaced scans which have been referred to the South Celestial Pole can provide a single calibrated baselevel for the Rhodes Survey. The observing technique and the necessary reduction programs to create a coarse grid of antenna temperatures of the Southern Sky using these observation are developed. Preliminary results for this technique are presented as a map of the region 18HR to 6HR, 90° to 30° with a 5°x5° resolution. On the astronomical side two studies are undertaken. The region 13HR to 23HR, -61° to -7° is searched for large extended areas of emission. 7 features occurring at intermediate galactic latitudes are found. They are interpreted as follows: one of them is the classical HII region surrounding the star Zeta Ophiuchi (l",b")=(6.7°,22.4°), and the rest are combinations of thermal and nonthermal emission from galactic features. The galactic equator profile for 24°> L > -58° is studied. It is dominated by a plateau of emission for L < -26°. This is interpreted as a combination of thermal and nonthermal radiation emitted by a ring of gas symmetric about the galactic centre with a radius of 4 - 6 kpc.
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  • Date Issued: 1984

Characters in search of a home: a study of themes in the work of David Storey

- Howie, Claerwen

  • Authors: Howie, Claerwen
  • Date: 1984
  • Subjects: Storey, David, 1933- -- Criticism and interpretation.
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:2275 , http://hdl.handle.net/10962/d1007222 , Storey, David, 1933- -- Criticism and interpretation.
  • Description: From Introduction: Anyone familiar with David Storey's work will find, on reading a brief outline of his life, that much of the inspiration for his novels and plays springs from personal experience. The third son of a coal-miner, he was born in Wakefield on 13 July 1933. He is one of three surviving sons, an older brother having died in childhood. (In Saville and In Celebration the death as a child of a mining family's eldest son has a powerful effect on the parents and some of the remaining brothers.) Although his father wanted his children to reach the middle class through education, Storey has indicated that this ambition was not pursued wholeheartedly.
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  • Date Issued: 1984

Christmas Song

- St Patricks' Church Choir, Lekona, E. Y., Dargie, Dave

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