Water-soluble quaternized mercaptopyridine-substituted zinc-phthalocyanines
- Durmuş, Mahmut, Yaman, Hanif, Göl, Cem, Ahsen, Vefa, Nyokong, Tebello
- Authors: Durmuş, Mahmut , Yaman, Hanif , Göl, Cem , Ahsen, Vefa , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247133 , vital:51549 , xlink:href="https://doi.org/10.1016/j.dyepig.2011.02.007"
- Description: The synthesis and characterization of the new zinc phthalocyanine derivatives, tetra- (non-peripheral, 5) and octa-(peripheral, 6) substituted with 2-mercaptopyridine and their respective quaternized derivatives (8 and 9) are reported. Photochemical and photophysical properties of the new complexes are compared with those of the previously reported peripherally tetra-substituted complexes 7 and 10. The quaternized compounds exhibit excellent solubility in water, making them potential photosensitizers for use in photodynamic therapy (PDT) of cancer. Spectroscopic, aggregation, photophysical and photochemical properties of these complexes are also investigated and compared. Photophysical (fluorescence quantum yields and lifetimes) and photochemical (singlet oxygen and photodegradation quantum yield) properties of these phthalocyanine photosensitizers are very important for the assessment of these complexes as PDT agents. In this study, the effects of the position of the substituents and quaternization of the substituents on the photophysical and photochemical parameters of the zinc phthalocyanines are also reported. This study also showed that the water-soluble quaternized zinc phthalocyanines strongly bind to blood plasma proteins such as bovine serum albumin (BSA).
- Full Text:
- Date Issued: 2011
- Authors: Durmuş, Mahmut , Yaman, Hanif , Göl, Cem , Ahsen, Vefa , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247133 , vital:51549 , xlink:href="https://doi.org/10.1016/j.dyepig.2011.02.007"
- Description: The synthesis and characterization of the new zinc phthalocyanine derivatives, tetra- (non-peripheral, 5) and octa-(peripheral, 6) substituted with 2-mercaptopyridine and their respective quaternized derivatives (8 and 9) are reported. Photochemical and photophysical properties of the new complexes are compared with those of the previously reported peripherally tetra-substituted complexes 7 and 10. The quaternized compounds exhibit excellent solubility in water, making them potential photosensitizers for use in photodynamic therapy (PDT) of cancer. Spectroscopic, aggregation, photophysical and photochemical properties of these complexes are also investigated and compared. Photophysical (fluorescence quantum yields and lifetimes) and photochemical (singlet oxygen and photodegradation quantum yield) properties of these phthalocyanine photosensitizers are very important for the assessment of these complexes as PDT agents. In this study, the effects of the position of the substituents and quaternization of the substituents on the photophysical and photochemical parameters of the zinc phthalocyanines are also reported. This study also showed that the water-soluble quaternized zinc phthalocyanines strongly bind to blood plasma proteins such as bovine serum albumin (BSA).
- Full Text:
- Date Issued: 2011
The design of a visitor education and research centre for Sutherland, Western Cape
- Du Toit, David Jacob Johannes
- Authors: Du Toit, David Jacob Johannes
- Date: 2011
- Subjects: Visitors' centers -- South Africa -- Western Cape -- Designs and plans Visitors' centers -- South Africa -- Western Cape
- Language: English
- Type: Thesis , Masters , MArch
- Identifier: http://hdl.handle.net/10948/38934 , vital:35014
- Description: The modern visitor centre evolved rapidly with the world wide growth in tourism and its significant contribution to local economies. This new building type has provided many new opportunities for architects to work on small to medium size building with a greater meaning attached to them. However, architects would now have to deal with the problems that tourists bring! How must architects incorporate local history, culture and memory? The visitor centre is the combination of the local tourism office and museum. This new type of building is a combination of those formerly distinct building types which had two separate and different functions. “gateway building” The contemporary visitor centre combines the distribution of tourist/visitor information with the interpretation of particular regions. This interpretation of cultural and natural history links the visitor centre to the local history museum, however whereas local history museums often struggle with expanding collections, limited resources and low visitation levels, visitor centres have been able to attract greater government funding. The media of interpretation also differs dramatically, with visitor’s centres often using multimedia technology to enliven cultural history or educational displays. However they can also suffer from static displays which having been viewed once, discourage repeat visits. What is a contemporary visitor centre? Figure 1: Guggenheim Museum, Bilbao. Showing centre as “icon” building. This interpretation role of visitor centres has resulted in them becoming a major focus for visitation. The must-see status of these buildings is often pursued through dramatic form. Briefs for visitor centres often demand an “icon” envisaging that the building will itself, become a marketable destination. Buildings that try and become destinations in themself often run the risk of not promoting the area or location but rather them self. Visitor centres can therefor contribute to the transformation of destinations in both positive and negative ways. They can either help with economic, environmental and cultural revival of regions or they can be involved in changing places and overshadowing the very features they are meant to enhance.
- Full Text:
- Date Issued: 2011
- Authors: Du Toit, David Jacob Johannes
- Date: 2011
- Subjects: Visitors' centers -- South Africa -- Western Cape -- Designs and plans Visitors' centers -- South Africa -- Western Cape
- Language: English
- Type: Thesis , Masters , MArch
- Identifier: http://hdl.handle.net/10948/38934 , vital:35014
- Description: The modern visitor centre evolved rapidly with the world wide growth in tourism and its significant contribution to local economies. This new building type has provided many new opportunities for architects to work on small to medium size building with a greater meaning attached to them. However, architects would now have to deal with the problems that tourists bring! How must architects incorporate local history, culture and memory? The visitor centre is the combination of the local tourism office and museum. This new type of building is a combination of those formerly distinct building types which had two separate and different functions. “gateway building” The contemporary visitor centre combines the distribution of tourist/visitor information with the interpretation of particular regions. This interpretation of cultural and natural history links the visitor centre to the local history museum, however whereas local history museums often struggle with expanding collections, limited resources and low visitation levels, visitor centres have been able to attract greater government funding. The media of interpretation also differs dramatically, with visitor’s centres often using multimedia technology to enliven cultural history or educational displays. However they can also suffer from static displays which having been viewed once, discourage repeat visits. What is a contemporary visitor centre? Figure 1: Guggenheim Museum, Bilbao. Showing centre as “icon” building. This interpretation role of visitor centres has resulted in them becoming a major focus for visitation. The must-see status of these buildings is often pursued through dramatic form. Briefs for visitor centres often demand an “icon” envisaging that the building will itself, become a marketable destination. Buildings that try and become destinations in themself often run the risk of not promoting the area or location but rather them self. Visitor centres can therefor contribute to the transformation of destinations in both positive and negative ways. They can either help with economic, environmental and cultural revival of regions or they can be involved in changing places and overshadowing the very features they are meant to enhance.
- Full Text:
- Date Issued: 2011
An investigation into the implementation of the basic antenatal care programme by midwives in Mdantsane clinics
- Authors: Dyeli, Nolwando
- Date: 2011
- Subjects: Primary health care -- South Africa -- Eastern Cape , Midwifery -- South Africa -- Eastern Cape , Childbirth -- South Africa -- Eastern Cape , Midwives -- South Africa -- Eastern Cape , Pregnancy -- South Africa -- Eastern Cape , Prenatal care -- South Africa -- Eastern Cape , Pregnant women -- Health and hygiene -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc (Nursing Science)
- Identifier: vital:11897 , http://hdl.handle.net/10353/425 , Primary health care -- South Africa -- Eastern Cape , Midwifery -- South Africa -- Eastern Cape , Childbirth -- South Africa -- Eastern Cape , Midwives -- South Africa -- Eastern Cape , Pregnancy -- South Africa -- Eastern Cape , Prenatal care -- South Africa -- Eastern Cape , Pregnant women -- Health and hygiene -- South Africa -- Eastern Cape
- Description: Basic Antenatal Care (BANC) is a way of training or upgrading the knowledge and skills of all nurses, midwives and doctors involved in antenatal care at the primary health care level so that the minimum care can be provided effectively. This study was conducted to investigate the implementation of the BANC program by midwives in the Mdantsane clinics during February 2009. Methods: A descriptive study design was undertaken targeting midwives providing antenatal care to pregnant women, in 14 clinics of Mdantsane. Data was collected from 25 midwives in the clinics, and from 140 ANC cards of women attending ANC on the day of their visit to the clinic. Results: The majority of midwives providing BANC in Mdantsane clinics were not trained in BANC. There were 10 trained midwives and 15 not yet trained. A total of twenty five midwives were involved in the study. The number of visits according to the BANC schedule was well known by the midwives in the study. The content of the visits was well known for the first visit, but for subsequent visits, the participating midwives could not state exactly what they do on these visits. They perceived BANC as something beneficial for both midwives and pregnant women with 24 of the participating midwives rating BANC as advantageous. In completing an ANC card, the midwives scored between 48 percent and 100 percent. Under examination, they scored between 52 percent and 100 percent. Lastly on interpretation and decision making, they scored between 0 percent and 92 percent. This could have troubling consequences for the health status of the mother and baby. Weaknesses in providing antenatal care identified in the study included participating midwives failing to fill in the last normal menstrual period (LNMP) and the estimated date of delivery (EDD), which was a worrying observation. Plotting of the gestational age at first visit was also not carried out well as only 47 percent of the midwives in the study did this, meaning that there would be a miscalculation of the gestational age thereafter throughout the pregnancies. The body mass index (BMI) was not calculated as the maternal height and weight were not written on the ANC card. This should be completed in order to check the nutritional status of the pregnant woman to help supplement, if malnourished, and educate on diet, if overweight. Only 17 percent of the midwives in the study plotted the foetal presentation. Failure to plot foetal presentation could lead to complications during delivery because women with abnormal presentations could end up delivering in a clinic instead of the hospital.Conclusion: This study showed that even though midwives are implementing BANC among pregnant women, it is not being carried out correctly. Therefore the programme will not be as beneficial as it would be if put into practice correctly. This is highlighted by the lack of knowledge from the untrained midwives regarding the content of care on subsequent visits. Thus there is an urgent need for BANC training to be conducted and monitored at various sites.
- Full Text:
- Date Issued: 2011
- Authors: Dyeli, Nolwando
- Date: 2011
- Subjects: Primary health care -- South Africa -- Eastern Cape , Midwifery -- South Africa -- Eastern Cape , Childbirth -- South Africa -- Eastern Cape , Midwives -- South Africa -- Eastern Cape , Pregnancy -- South Africa -- Eastern Cape , Prenatal care -- South Africa -- Eastern Cape , Pregnant women -- Health and hygiene -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc (Nursing Science)
- Identifier: vital:11897 , http://hdl.handle.net/10353/425 , Primary health care -- South Africa -- Eastern Cape , Midwifery -- South Africa -- Eastern Cape , Childbirth -- South Africa -- Eastern Cape , Midwives -- South Africa -- Eastern Cape , Pregnancy -- South Africa -- Eastern Cape , Prenatal care -- South Africa -- Eastern Cape , Pregnant women -- Health and hygiene -- South Africa -- Eastern Cape
- Description: Basic Antenatal Care (BANC) is a way of training or upgrading the knowledge and skills of all nurses, midwives and doctors involved in antenatal care at the primary health care level so that the minimum care can be provided effectively. This study was conducted to investigate the implementation of the BANC program by midwives in the Mdantsane clinics during February 2009. Methods: A descriptive study design was undertaken targeting midwives providing antenatal care to pregnant women, in 14 clinics of Mdantsane. Data was collected from 25 midwives in the clinics, and from 140 ANC cards of women attending ANC on the day of their visit to the clinic. Results: The majority of midwives providing BANC in Mdantsane clinics were not trained in BANC. There were 10 trained midwives and 15 not yet trained. A total of twenty five midwives were involved in the study. The number of visits according to the BANC schedule was well known by the midwives in the study. The content of the visits was well known for the first visit, but for subsequent visits, the participating midwives could not state exactly what they do on these visits. They perceived BANC as something beneficial for both midwives and pregnant women with 24 of the participating midwives rating BANC as advantageous. In completing an ANC card, the midwives scored between 48 percent and 100 percent. Under examination, they scored between 52 percent and 100 percent. Lastly on interpretation and decision making, they scored between 0 percent and 92 percent. This could have troubling consequences for the health status of the mother and baby. Weaknesses in providing antenatal care identified in the study included participating midwives failing to fill in the last normal menstrual period (LNMP) and the estimated date of delivery (EDD), which was a worrying observation. Plotting of the gestational age at first visit was also not carried out well as only 47 percent of the midwives in the study did this, meaning that there would be a miscalculation of the gestational age thereafter throughout the pregnancies. The body mass index (BMI) was not calculated as the maternal height and weight were not written on the ANC card. This should be completed in order to check the nutritional status of the pregnant woman to help supplement, if malnourished, and educate on diet, if overweight. Only 17 percent of the midwives in the study plotted the foetal presentation. Failure to plot foetal presentation could lead to complications during delivery because women with abnormal presentations could end up delivering in a clinic instead of the hospital.Conclusion: This study showed that even though midwives are implementing BANC among pregnant women, it is not being carried out correctly. Therefore the programme will not be as beneficial as it would be if put into practice correctly. This is highlighted by the lack of knowledge from the untrained midwives regarding the content of care on subsequent visits. Thus there is an urgent need for BANC training to be conducted and monitored at various sites.
- Full Text:
- Date Issued: 2011
The survival strategies of unemployed rural women : a case study of Wooldridge
- Authors: Dyubhele, Noluntu Stella
- Date: 2011
- Subjects: Women in rural development -- South Africa -- Eastern Cape , Rural women -- South Africa -- Eastern Cape , Unemployment -- South Africa -- Eastern Cape , Sustainable development -- South Africa -- Eastern Cape , Poverty -- Government policy -- South Africa -- Eastern Cape , Rural poor -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Doctoral , DCom
- Identifier: vital:8982 , http://hdl.handle.net/10948/1651 , Women in rural development -- South Africa -- Eastern Cape , Rural women -- South Africa -- Eastern Cape , Unemployment -- South Africa -- Eastern Cape , Sustainable development -- South Africa -- Eastern Cape , Poverty -- Government policy -- South Africa -- Eastern Cape , Rural poor -- South Africa -- Eastern Cape
- Description: Despite decades of gender research and public action by civil society, policy makers continue to neglect the role of women as breadwinners who work at improving the socio-economic conditions in rural areas such as Wooldridge, a traditional rural village in the Amathole district of the Eastern Cape Province. The apartheid system created an environment that continues to perpetuate both poverty and gender inequality in rural areas. Hence, rural women in Wooldridge still experience poverty, despite welfare benefits. They are located in a poverty-stricken area without basic infrastructure and with little or no access to economic assets. They use primitive methods and indigenous knowledge to develop survival strategies. This study argues that unemployed rural women in Wooldridge cannot survive without assistance from government. Indigenous knowledge and agricultural as well as non-agricultural activities are critical to household livelihoods in Wooldridge. These activities are an important route through which these rural women can escape poverty. The primary objective of this research was to obtain a better understanding of how unemployed rural women survive in Wooldridge. Furthermore, the necessary conditions required to sustain livelihood in the rural areas were identified. This was mainly done to help alleviate the plight of rural women in Wooldridge and to improve the quality of life of the rural population. The aim is to generate a policy response to rural women that is economically development-oriented. The study was based on five research objectives. The first objective was to identify the survival strategies of unemployed rural women in Wooldridge; the second to ascertain what can be done to alleviate the plight of rural women in Wooldridge. The third objective was to ascertain what has been v done to address the needs of rural women in the Wooldridge area by actors of development, such as government and non-governmental organisations. The fourth objective was to identify the constraints faced by unemployed rural women in Wooldridge in achieving food security and generating income, with the last objective to make recommendations regarding policies that can enhance rural economic development and assist unemployed rural women to reduce poverty. The main finding in terms of the first research objective is that the survival strategies of unemployed rural women are welfare benefits, the selling of assets, remittances, handicraft production and vegetable gardens. In terms of the second research objective, the main finding is that investment in human capital through the empowerment of women will assist them in improving the quality of life of the Wooldridge community. Empowerment involves skills and training, education and access to basic services, expertise regarding credit, land, the growing of vegetables and income-generating projects. The main finding in terms of the third research objective is that the Peddie Women Support Centre that is located in the city centre of Ngqushwa does not have the capacity to reach out to rural areas. Rural women in Wooldridge have not received responses to their plights from government or from development practitioners. These actors of development play an important role in empowerment. In terms of the fourth research objective, the main finding is that structural constraints hinder the economic activity of rural women in Wooldridge. Government policy that encourages investment in infrastructure using labour-intensive methods will eliminate service backlogs in underserviced areas such as Wooldridge. The main finding in terms of the fifth research objective is to ascertain the impact that new legislation can have to ensure that rural women have the same access and entitlement to land and resources as women from urban areas. Furthermore, service-improvement programmes should be developed and micro-enterprises and agricultural and non-agricultural activities that will generate income and employment should be encouraged in order to reduce poverty in Wooldridge.
- Full Text:
- Date Issued: 2011
- Authors: Dyubhele, Noluntu Stella
- Date: 2011
- Subjects: Women in rural development -- South Africa -- Eastern Cape , Rural women -- South Africa -- Eastern Cape , Unemployment -- South Africa -- Eastern Cape , Sustainable development -- South Africa -- Eastern Cape , Poverty -- Government policy -- South Africa -- Eastern Cape , Rural poor -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Doctoral , DCom
- Identifier: vital:8982 , http://hdl.handle.net/10948/1651 , Women in rural development -- South Africa -- Eastern Cape , Rural women -- South Africa -- Eastern Cape , Unemployment -- South Africa -- Eastern Cape , Sustainable development -- South Africa -- Eastern Cape , Poverty -- Government policy -- South Africa -- Eastern Cape , Rural poor -- South Africa -- Eastern Cape
- Description: Despite decades of gender research and public action by civil society, policy makers continue to neglect the role of women as breadwinners who work at improving the socio-economic conditions in rural areas such as Wooldridge, a traditional rural village in the Amathole district of the Eastern Cape Province. The apartheid system created an environment that continues to perpetuate both poverty and gender inequality in rural areas. Hence, rural women in Wooldridge still experience poverty, despite welfare benefits. They are located in a poverty-stricken area without basic infrastructure and with little or no access to economic assets. They use primitive methods and indigenous knowledge to develop survival strategies. This study argues that unemployed rural women in Wooldridge cannot survive without assistance from government. Indigenous knowledge and agricultural as well as non-agricultural activities are critical to household livelihoods in Wooldridge. These activities are an important route through which these rural women can escape poverty. The primary objective of this research was to obtain a better understanding of how unemployed rural women survive in Wooldridge. Furthermore, the necessary conditions required to sustain livelihood in the rural areas were identified. This was mainly done to help alleviate the plight of rural women in Wooldridge and to improve the quality of life of the rural population. The aim is to generate a policy response to rural women that is economically development-oriented. The study was based on five research objectives. The first objective was to identify the survival strategies of unemployed rural women in Wooldridge; the second to ascertain what can be done to alleviate the plight of rural women in Wooldridge. The third objective was to ascertain what has been v done to address the needs of rural women in the Wooldridge area by actors of development, such as government and non-governmental organisations. The fourth objective was to identify the constraints faced by unemployed rural women in Wooldridge in achieving food security and generating income, with the last objective to make recommendations regarding policies that can enhance rural economic development and assist unemployed rural women to reduce poverty. The main finding in terms of the first research objective is that the survival strategies of unemployed rural women are welfare benefits, the selling of assets, remittances, handicraft production and vegetable gardens. In terms of the second research objective, the main finding is that investment in human capital through the empowerment of women will assist them in improving the quality of life of the Wooldridge community. Empowerment involves skills and training, education and access to basic services, expertise regarding credit, land, the growing of vegetables and income-generating projects. The main finding in terms of the third research objective is that the Peddie Women Support Centre that is located in the city centre of Ngqushwa does not have the capacity to reach out to rural areas. Rural women in Wooldridge have not received responses to their plights from government or from development practitioners. These actors of development play an important role in empowerment. In terms of the fourth research objective, the main finding is that structural constraints hinder the economic activity of rural women in Wooldridge. Government policy that encourages investment in infrastructure using labour-intensive methods will eliminate service backlogs in underserviced areas such as Wooldridge. The main finding in terms of the fifth research objective is to ascertain the impact that new legislation can have to ensure that rural women have the same access and entitlement to land and resources as women from urban areas. Furthermore, service-improvement programmes should be developed and micro-enterprises and agricultural and non-agricultural activities that will generate income and employment should be encouraged in order to reduce poverty in Wooldridge.
- Full Text:
- Date Issued: 2011
Work-family conflict, stress and some demographic and occupational variables among female factory workers in East London, South Africa
- Authors: Dywili, Mtutuzeli
- Date: 2011
- Subjects: Work and family -- South Africa , Job stress -- South Africa , Women employees -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/24128 , vital:62382
- Description: The study examines work-family conflict, stress, and some demographic and occupational variables among female factory workers in East London, South Africa. The participants were female factory workers in East London, South Africa. The independent variables for the study were, demographic and occupational variables, while stress is the dependent variable. Work-family conflict is dependent on demographic and occupational variables, while on the other hand is independent to stress. The demographic variables concerned are age, marital status, number of children and age of the last born child. The occupational variable on the other hand is occupational level, i.e. managerial versus non-managerial. The measuring instruments were a self-designed questionnaire to measure the demographic and occupational variables, a questionnaire developed by Stephens and Sommer (1996) to measure work-family conflict (cronbach’s alpha = 0,90) and the Effort – Reward Imbalance (ERI) questionnaire (Pikhart, Bobak, Siegrist, Pajak, Rywick, Kyshegyi, Gostaus, Skodova& Marmot, 1996) to measure stress at workplace. Cronbach’s alpha for the whole questionnaire reaches the value of 0,89. , Thesis (MCom) -- Faculty of Management and Commerce, 2011
- Full Text:
- Date Issued: 2011
- Authors: Dywili, Mtutuzeli
- Date: 2011
- Subjects: Work and family -- South Africa , Job stress -- South Africa , Women employees -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/24128 , vital:62382
- Description: The study examines work-family conflict, stress, and some demographic and occupational variables among female factory workers in East London, South Africa. The participants were female factory workers in East London, South Africa. The independent variables for the study were, demographic and occupational variables, while stress is the dependent variable. Work-family conflict is dependent on demographic and occupational variables, while on the other hand is independent to stress. The demographic variables concerned are age, marital status, number of children and age of the last born child. The occupational variable on the other hand is occupational level, i.e. managerial versus non-managerial. The measuring instruments were a self-designed questionnaire to measure the demographic and occupational variables, a questionnaire developed by Stephens and Sommer (1996) to measure work-family conflict (cronbach’s alpha = 0,90) and the Effort – Reward Imbalance (ERI) questionnaire (Pikhart, Bobak, Siegrist, Pajak, Rywick, Kyshegyi, Gostaus, Skodova& Marmot, 1996) to measure stress at workplace. Cronbach’s alpha for the whole questionnaire reaches the value of 0,89. , Thesis (MCom) -- Faculty of Management and Commerce, 2011
- Full Text:
- Date Issued: 2011
The determinants of happiness among race groups in South Africa
- Ebrahim, Amina, Botha, Ferdi, Snowball, Jeanette D
- Authors: Ebrahim, Amina , Botha, Ferdi , Snowball, Jeanette D
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68589 , vital:29291 , http://www.essa2011.org.za/fullpaper/essa2011_2182.pdf
- Description: Publisher version , Economic indicators, like GDP per capita, are commonly used as indicators of welfare. However, they have a very limited and narrow scope, excluding many potentially important welfare determinants, such as health, relative income and religion - not surprising since they were not originally designed to fill this role. There is thus growing acceptance, and use of, subjective measure of wellbeing, (called ‘happiness’ measures) both worldwide and in South Africa. Happiness economics does not propose to replace income based measure of wellbeing, but rather attempts to compliment them with broader measures, which can be important in making policy decisions that optimise societal welfare. This paper tests for differences in subjective wellbeing between race groups in South Africa, and investigates the determinants of self-rated life satisfaction (happiness) for each group. Using the 2008 National Income Dynamics Study (NIDS) data, descriptive methods (ANOVA) and an ordered probit model are applied. Results indicate that reported happiness differs substantially among race groups, with black South Africans being the least happy group despite changes since the advent of democracy in 1994. Higher levels of educational attainment increase satisfaction for the whole sample, and women are generally less happy than men (particularly black women). As found in many other studies, unemployed people have lower levels of life satisfaction than the employed, even when controlling for income and relative income. The determinants of happiness are also different for each race group: While white South Africans attached greater importance to physical health; employment status and absolute income matter greatly for black people. For coloured people and black people, positional status (as measured by relative income) is an important determinant of happiness, with religious involvement significantly contributing to the happiness of Indian people.
- Full Text:
- Date Issued: 2011
- Authors: Ebrahim, Amina , Botha, Ferdi , Snowball, Jeanette D
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68589 , vital:29291 , http://www.essa2011.org.za/fullpaper/essa2011_2182.pdf
- Description: Publisher version , Economic indicators, like GDP per capita, are commonly used as indicators of welfare. However, they have a very limited and narrow scope, excluding many potentially important welfare determinants, such as health, relative income and religion - not surprising since they were not originally designed to fill this role. There is thus growing acceptance, and use of, subjective measure of wellbeing, (called ‘happiness’ measures) both worldwide and in South Africa. Happiness economics does not propose to replace income based measure of wellbeing, but rather attempts to compliment them with broader measures, which can be important in making policy decisions that optimise societal welfare. This paper tests for differences in subjective wellbeing between race groups in South Africa, and investigates the determinants of self-rated life satisfaction (happiness) for each group. Using the 2008 National Income Dynamics Study (NIDS) data, descriptive methods (ANOVA) and an ordered probit model are applied. Results indicate that reported happiness differs substantially among race groups, with black South Africans being the least happy group despite changes since the advent of democracy in 1994. Higher levels of educational attainment increase satisfaction for the whole sample, and women are generally less happy than men (particularly black women). As found in many other studies, unemployed people have lower levels of life satisfaction than the employed, even when controlling for income and relative income. The determinants of happiness are also different for each race group: While white South Africans attached greater importance to physical health; employment status and absolute income matter greatly for black people. For coloured people and black people, positional status (as measured by relative income) is an important determinant of happiness, with religious involvement significantly contributing to the happiness of Indian people.
- Full Text:
- Date Issued: 2011
Assessing the impact of unions and related barriers in lean manufacturing implementation within Eastern Cape automotive component suppliers
- Authors: Ebrahim, Zahier
- Date: 2011
- Subjects: Lean manufacturing , Motor industry -- South Africa -- Eastern Cape , Labor unions -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8791 , http://hdl.handle.net/10948/d1015690
- Description: Lean manufacturing provides a fundamental basis for competitiveness in the auto component sector. The implementation and sustainability of the lean philosophy are important aspects when deciding on the adoption of the lean concept within organisations. Various barriers to implementation present themselves during and after lean implementation. These barriers are often related and in some instances they may be converted from an impediment into an enabler of lean within companies. The impact of unions as a negative or positive influence forms a central focus of this research. The influences on the perception of unions and their constituents are studied in relation to other barriers in order to determine their relevance in the Eastern Cape auto sector. A research questionnaire was constructed in line with the selected research design. The application of triangulation in the research design allows for greater depth in the responses from the participants in this research. The quantitative analysis combined with the qualitative thematic analysis provides an excellent means to explore and understand these selected barriers to lean in great detail. It can be concluded that automotive trade unions in the Eastern Cape are a barrier to implementation; however the factor that influences lean the most is the incorrect perception of lean due to ineffective leadership practices among organisational and union leaders, among other barriers. The impact of unions on the acceptance of a lean culture has far-reaching implications for the auto sector that requires a specific implementation approach in order to change perceptions and gain the requisite interest alignment among unions and their constituents.
- Full Text:
- Date Issued: 2011
- Authors: Ebrahim, Zahier
- Date: 2011
- Subjects: Lean manufacturing , Motor industry -- South Africa -- Eastern Cape , Labor unions -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8791 , http://hdl.handle.net/10948/d1015690
- Description: Lean manufacturing provides a fundamental basis for competitiveness in the auto component sector. The implementation and sustainability of the lean philosophy are important aspects when deciding on the adoption of the lean concept within organisations. Various barriers to implementation present themselves during and after lean implementation. These barriers are often related and in some instances they may be converted from an impediment into an enabler of lean within companies. The impact of unions as a negative or positive influence forms a central focus of this research. The influences on the perception of unions and their constituents are studied in relation to other barriers in order to determine their relevance in the Eastern Cape auto sector. A research questionnaire was constructed in line with the selected research design. The application of triangulation in the research design allows for greater depth in the responses from the participants in this research. The quantitative analysis combined with the qualitative thematic analysis provides an excellent means to explore and understand these selected barriers to lean in great detail. It can be concluded that automotive trade unions in the Eastern Cape are a barrier to implementation; however the factor that influences lean the most is the incorrect perception of lean due to ineffective leadership practices among organisational and union leaders, among other barriers. The impact of unions on the acceptance of a lean culture has far-reaching implications for the auto sector that requires a specific implementation approach in order to change perceptions and gain the requisite interest alignment among unions and their constituents.
- Full Text:
- Date Issued: 2011
Nanostructures and metallophthalocyanines : applications in microbial fuel cells
- Authors: Edwards, Sean
- Date: 2011
- Subjects: Microbial fuel cells , Waste products as fuel , Nanostructured materials , Electrochemistry , Nanotubes
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4107 , http://hdl.handle.net/10962/d1011742 , Microbial fuel cells , Waste products as fuel , Nanostructured materials , Electrochemistry , Nanotubes
- Description: Microbial fuel cells (MFCs) are a promising form of alternative energy capable of harnessing the potential energy stores in organic waste. The oxygen reduction reaction (ORR) forms an integral role in the generation of electricity in MFCs however it is also a potential obstacle in enhancing the performance of MFCs. Platinum, a commonly used catalyst for the ORR, is expensive and rare. Significant research has been conducted into developing alternative catalysts. Metallophthalocyanines (MPc) have garnered attention for use as catalysts. Iron phthalocyanine (FePc) has been shown to have catalytic activity towards the reduction of oxygen. Coupling of the catalyst to nanostructured carbon materials, such as multi-walled carbon nanotubes, has been observed to have several advantages as nanostructures have a high surface-to-volume ratio. In this study, we have attempted to assess the suitability of FePc, both its bulk and nanostructured form, as an oxygen reduction catalyst and acid functionalized multi-walled carbon nanotubes for use as a catalyst support using electrochemical techniques such as cyclic voltammetry and electrochemical impedance spectroscopy. We showed, for the first time, the catalytic nature of nanostructured FePc towards the ORR. Applying the data obtained from the electrochemical analyses, electrodes were modified using FePc and MWCNTs and applied to an Enterobacter cloacae-based MFC. Several operational parameters of the MFC, such as temperature and ionic strength, were optimized during the course of the study. We showed that optimized FePc:MWCNT-modified electrodes compared favourably to platinum-based electrodes in terms of power densities obtained in a microbial fuel cell.
- Full Text:
- Date Issued: 2011
- Authors: Edwards, Sean
- Date: 2011
- Subjects: Microbial fuel cells , Waste products as fuel , Nanostructured materials , Electrochemistry , Nanotubes
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4107 , http://hdl.handle.net/10962/d1011742 , Microbial fuel cells , Waste products as fuel , Nanostructured materials , Electrochemistry , Nanotubes
- Description: Microbial fuel cells (MFCs) are a promising form of alternative energy capable of harnessing the potential energy stores in organic waste. The oxygen reduction reaction (ORR) forms an integral role in the generation of electricity in MFCs however it is also a potential obstacle in enhancing the performance of MFCs. Platinum, a commonly used catalyst for the ORR, is expensive and rare. Significant research has been conducted into developing alternative catalysts. Metallophthalocyanines (MPc) have garnered attention for use as catalysts. Iron phthalocyanine (FePc) has been shown to have catalytic activity towards the reduction of oxygen. Coupling of the catalyst to nanostructured carbon materials, such as multi-walled carbon nanotubes, has been observed to have several advantages as nanostructures have a high surface-to-volume ratio. In this study, we have attempted to assess the suitability of FePc, both its bulk and nanostructured form, as an oxygen reduction catalyst and acid functionalized multi-walled carbon nanotubes for use as a catalyst support using electrochemical techniques such as cyclic voltammetry and electrochemical impedance spectroscopy. We showed, for the first time, the catalytic nature of nanostructured FePc towards the ORR. Applying the data obtained from the electrochemical analyses, electrodes were modified using FePc and MWCNTs and applied to an Enterobacter cloacae-based MFC. Several operational parameters of the MFC, such as temperature and ionic strength, were optimized during the course of the study. We showed that optimized FePc:MWCNT-modified electrodes compared favourably to platinum-based electrodes in terms of power densities obtained in a microbial fuel cell.
- Full Text:
- Date Issued: 2011
A psychobiography of Archbishop Emeritus Desmond Mpilo Tutu
- Authors: Eliastam, Liesl Marijke
- Date: 2011
- Subjects: Developmental psychology , Life cycle, Human -- Psychological aspects , Psychology -- Biographical methods , Personality -- Research -- Methodology , Emotional intelligence
- Language: English
- Type: Thesis , Masters , M Soc Sc (C Psy)
- Identifier: vital:11856 , http://hdl.handle.net/10353/537 , Developmental psychology , Life cycle, Human -- Psychological aspects , Psychology -- Biographical methods , Personality -- Research -- Methodology , Emotional intelligence
- Description: Psychobiographies offer the illuminating experience of uncovering the story of an individual’s life through the lens of a psychological theory. Psychobiographies offer the chance to gain a deeper understanding of what makes that individual unique. This study aimed to explore and describe the emotional intelligence of Archbishop Emeritus Desmond Tutu according to Goleman’s (1998) theory of Emotional Intelligence. Tutu was chosen as a subject for this study because of his extraordinary life and accomplishments, and because he is regarded as a prominent figure of moral leadership in South Africa. A qualitative psychobiographical research method was utilised. Data was collected from both primary and secondary sources to enhance internal validity, and was then analysed according to Miles and Huberman’s (1994) approach. The findings suggest that Tutu applied all of the twenty five emotional intelligence capacities during his life, and that at times, some were used more extensively than others. This study is groundbreaking in that it is the first psychobiography on Desmond Tutu, and it is the first psychobiography undertaken at the University of Fort Hare. Psychobiographies offer an opportunity to evaluate the psychological theory which is applied. It was found that Goleman’s (1998) theory of Emotional Intelligence is supported by this study.
- Full Text:
- Date Issued: 2011
- Authors: Eliastam, Liesl Marijke
- Date: 2011
- Subjects: Developmental psychology , Life cycle, Human -- Psychological aspects , Psychology -- Biographical methods , Personality -- Research -- Methodology , Emotional intelligence
- Language: English
- Type: Thesis , Masters , M Soc Sc (C Psy)
- Identifier: vital:11856 , http://hdl.handle.net/10353/537 , Developmental psychology , Life cycle, Human -- Psychological aspects , Psychology -- Biographical methods , Personality -- Research -- Methodology , Emotional intelligence
- Description: Psychobiographies offer the illuminating experience of uncovering the story of an individual’s life through the lens of a psychological theory. Psychobiographies offer the chance to gain a deeper understanding of what makes that individual unique. This study aimed to explore and describe the emotional intelligence of Archbishop Emeritus Desmond Tutu according to Goleman’s (1998) theory of Emotional Intelligence. Tutu was chosen as a subject for this study because of his extraordinary life and accomplishments, and because he is regarded as a prominent figure of moral leadership in South Africa. A qualitative psychobiographical research method was utilised. Data was collected from both primary and secondary sources to enhance internal validity, and was then analysed according to Miles and Huberman’s (1994) approach. The findings suggest that Tutu applied all of the twenty five emotional intelligence capacities during his life, and that at times, some were used more extensively than others. This study is groundbreaking in that it is the first psychobiography on Desmond Tutu, and it is the first psychobiography undertaken at the University of Fort Hare. Psychobiographies offer an opportunity to evaluate the psychological theory which is applied. It was found that Goleman’s (1998) theory of Emotional Intelligence is supported by this study.
- Full Text:
- Date Issued: 2011
Knowing, acting and being: Epistemological and ontological access in a Science Extended Studies course
- Authors: Ellery, Karen
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/69471 , vital:29540 , https://hdl.handle.net/10520/EJC37737
- Description: Gross participation and throughput rates in higher education institutions in South Africa indicate an inequitable and poorly functioning system. This interpretive study argues for an approach that enhances epistemological and ontological access and examines how an intervention that includes an overt approach in dealing with the nature of science, coupled with student involvement in an independent research project in a Science Extended Studies course, can enhance such access to higher education study. Analysis of project outcomes and student critical reflections indicated access to scientific and academic Discourses was enhanced through: developing improved procedural and conceptual scientific knowledge; meaningful engagement with the language, norms and conventions of the Discourse; integrating everyday knowledge into more abstract scientific knowledge; awareness of the process of validation of scientific knowledge, of the limitations of science, and of the impact of science on society; and transforming personally by developing scientific discursive identity and a sense of belonging. In conclusion, it is argued that curriculum interventions that focus on epistemological and ontological aspects of learning could appropriately be used throughout the higher education science sector.
- Full Text:
- Date Issued: 2011
- Authors: Ellery, Karen
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/69471 , vital:29540 , https://hdl.handle.net/10520/EJC37737
- Description: Gross participation and throughput rates in higher education institutions in South Africa indicate an inequitable and poorly functioning system. This interpretive study argues for an approach that enhances epistemological and ontological access and examines how an intervention that includes an overt approach in dealing with the nature of science, coupled with student involvement in an independent research project in a Science Extended Studies course, can enhance such access to higher education study. Analysis of project outcomes and student critical reflections indicated access to scientific and academic Discourses was enhanced through: developing improved procedural and conceptual scientific knowledge; meaningful engagement with the language, norms and conventions of the Discourse; integrating everyday knowledge into more abstract scientific knowledge; awareness of the process of validation of scientific knowledge, of the limitations of science, and of the impact of science on society; and transforming personally by developing scientific discursive identity and a sense of belonging. In conclusion, it is argued that curriculum interventions that focus on epistemological and ontological aspects of learning could appropriately be used throughout the higher education science sector.
- Full Text:
- Date Issued: 2011
Integrating scholastic and practice-centred epistemologies in a post-graduate professional degree
- Ellery, Karen, Lotz-Sisitka, Heila
- Authors: Ellery, Karen , Lotz-Sisitka, Heila
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/391207 , vital:68631 , xlink:href="https://hdl.handle.net/10520/EJC37710"
- Description: This article argues for the integration of both scholastic and practice-centred epistemologies within an Environmental Education (EE) post-graduate curriculum that is oriented towards sustainability and socio-ecological justice. It is an interpretive study based on an in-depth analysis of five assignments by four scholars registered for the M.Ed. EE course at Rhodes University where a contextualised, reflexive research process, based in a work-place context, forms the integrative pedagogic tool. Analyses indicate that involving students in such a process, with close support and guidance, is an effective means of developing both scholastic and practical epistemologies. It is concluded that research-led integration of scholastic and practice-centred epistemologies in a transformational curriculum has the potential to provide epistemological access to the academy, advance knowledge within disciplines, and challenge the dominance of scholastic knowledge in higher education settings.
- Full Text:
- Date Issued: 2011
- Authors: Ellery, Karen , Lotz-Sisitka, Heila
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/391207 , vital:68631 , xlink:href="https://hdl.handle.net/10520/EJC37710"
- Description: This article argues for the integration of both scholastic and practice-centred epistemologies within an Environmental Education (EE) post-graduate curriculum that is oriented towards sustainability and socio-ecological justice. It is an interpretive study based on an in-depth analysis of five assignments by four scholars registered for the M.Ed. EE course at Rhodes University where a contextualised, reflexive research process, based in a work-place context, forms the integrative pedagogic tool. Analyses indicate that involving students in such a process, with close support and guidance, is an effective means of developing both scholastic and practical epistemologies. It is concluded that research-led integration of scholastic and practice-centred epistemologies in a transformational curriculum has the potential to provide epistemological access to the academy, advance knowledge within disciplines, and challenge the dominance of scholastic knowledge in higher education settings.
- Full Text:
- Date Issued: 2011
A case study investigation into drama in education as an effective teaching methodology to support the goals of outcome based education
- Authors: Elliott, Terri Anne
- Date: 2011
- Subjects: Drama in education -- South Africa Competency based education -- South Africa Curriculum planning -- South Africa Student centered learning -- South Africa Critical thinking -- Study and teaching -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2160 , http://hdl.handle.net/10962/d1008306
- Description: The introduction of outcomes based education (OBE) in the form of Curriculum 2005 (C2005), the National Curriculum Statement (NCS) and the Revised National Curriculum Statement (RNCS) in post-apartheid South Africa resulted in a shift from a content-centred to a learner-centred view on education. This transition took place rapidly as the new government wanted to introduce a democratic education system after the divisive Bantu education system from Apartheid. However, after the changes were implemented, education in South Africa was theoretically outcomes based but practically many educators were still teaching in a content-centred manner. The research puts forward the proposal that drama-in-education (D-i-E) is a useful means by which to align the practical and theoretical goals of OBE within the context of South Africa's current RNCS. This hypothesis drives the main research question: "Can D-i-E be an effective teaching methodology to realise the goals of the RNCS and generate OBE learning environments in a South African high school?" D-i-E is a learner-centred teaching methodology and in practise it meets many of the goals and Critical Cross-Field Outcomes (CCFOs) of OBE. Some of these include the fact that learners can: • Practice problem-solving skills; • Engage with critical and creative thinking; • Grow cultural and aesthetic sensitivity; • Work effectively in groups; and ii. • Learn in inclusive environments that cater for different learning styles and levels. The research examines the use of D-i-E as an outcomes based methodology by which the RNCS could be implemented in the classroom. This is explored through the use of qualitative research in the form of a case study investigation at a South African high school. The case study was conducted with Grade 11 and Grade 12 Dramatic Arts learners and involves an analysis of a D-i-E approach to learning. The conclusion that D-i-E is an effective outcomes based teaching methodology which could assist educators in realising the RNCS was largely reached through participant observation of D-i-E classes and by analysing the learners' journals in which they reflected on D-i-E experiences. The learners' feedback about the experience was generally positive and they reflected that they found D-i-E beneficial because of the fact that it engaged them experientially. They also reflected that D-i-E provided them with a more meaningful and exciting way of learning. These findings are however only generalisable to the type of context (Dramatic Arts learners from a well-resourced girls' high school) in which the research was conducted. The findings provide detailed insight into a specific case study and may be beneficial to educators in South Africa who aim to make use of the same or similar methodologies in their classroom practice. D-i-E also supports many of the underlying tenants of OBE such as learner-centredness, learner diversity and inclusive learning, and can effectively aid educators in implementing the RNCS in an outcomes based way.
- Full Text:
- Date Issued: 2011
- Authors: Elliott, Terri Anne
- Date: 2011
- Subjects: Drama in education -- South Africa Competency based education -- South Africa Curriculum planning -- South Africa Student centered learning -- South Africa Critical thinking -- Study and teaching -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2160 , http://hdl.handle.net/10962/d1008306
- Description: The introduction of outcomes based education (OBE) in the form of Curriculum 2005 (C2005), the National Curriculum Statement (NCS) and the Revised National Curriculum Statement (RNCS) in post-apartheid South Africa resulted in a shift from a content-centred to a learner-centred view on education. This transition took place rapidly as the new government wanted to introduce a democratic education system after the divisive Bantu education system from Apartheid. However, after the changes were implemented, education in South Africa was theoretically outcomes based but practically many educators were still teaching in a content-centred manner. The research puts forward the proposal that drama-in-education (D-i-E) is a useful means by which to align the practical and theoretical goals of OBE within the context of South Africa's current RNCS. This hypothesis drives the main research question: "Can D-i-E be an effective teaching methodology to realise the goals of the RNCS and generate OBE learning environments in a South African high school?" D-i-E is a learner-centred teaching methodology and in practise it meets many of the goals and Critical Cross-Field Outcomes (CCFOs) of OBE. Some of these include the fact that learners can: • Practice problem-solving skills; • Engage with critical and creative thinking; • Grow cultural and aesthetic sensitivity; • Work effectively in groups; and ii. • Learn in inclusive environments that cater for different learning styles and levels. The research examines the use of D-i-E as an outcomes based methodology by which the RNCS could be implemented in the classroom. This is explored through the use of qualitative research in the form of a case study investigation at a South African high school. The case study was conducted with Grade 11 and Grade 12 Dramatic Arts learners and involves an analysis of a D-i-E approach to learning. The conclusion that D-i-E is an effective outcomes based teaching methodology which could assist educators in realising the RNCS was largely reached through participant observation of D-i-E classes and by analysing the learners' journals in which they reflected on D-i-E experiences. The learners' feedback about the experience was generally positive and they reflected that they found D-i-E beneficial because of the fact that it engaged them experientially. They also reflected that D-i-E provided them with a more meaningful and exciting way of learning. These findings are however only generalisable to the type of context (Dramatic Arts learners from a well-resourced girls' high school) in which the research was conducted. The findings provide detailed insight into a specific case study and may be beneficial to educators in South Africa who aim to make use of the same or similar methodologies in their classroom practice. D-i-E also supports many of the underlying tenants of OBE such as learner-centredness, learner diversity and inclusive learning, and can effectively aid educators in implementing the RNCS in an outcomes based way.
- Full Text:
- Date Issued: 2011
Performance improvement in South African construction
- Authors: Emuze, Fidelis Abumere
- Date: 2011
- Subjects: Construction industry -- South Africa -- Management , Project management -- South Africa , Construction projects -- Management , Business logistics -- South Africa -- Management
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:9678 , http://hdl.handle.net/10948/1642 , Construction industry -- South Africa -- Management , Project management -- South Africa , Construction projects -- Management , Business logistics -- South Africa -- Management
- Description: In general, dreams are conceived, ideas are conceptualised, and initiatives are embarked upon in order to alter the state of realities. Dreams change realities; when mechanisms are put in place to realise them, dreams succeed. However, anecdotal evidence as well as empirical findings has continued to reiterate the difficulties associated with realising dreams related to construction projects. Extending the „dream‟ analogy to the South African construction industry context therefore paints an uninspiring picture. Dreams associated with construction do not have a 100% chance of becoming realities as evident in reported poor project performance in the industry. Shattered dreams in the form of poor performing projects, poorly implemented construction processes, or worst, projects delivered at the expense of unexpected cost to the client as a direct result of poor H&S or time overruns, negate the intent of dreams. This thesis is primarily concerned with project performance related bottlenecks in South African construction. After an extensive review of related literature that entails the analysis of publications related to non-value adding activities (NVAAs), supply chain management (SCM), and system dynamics (SD) in the construction project management realm, an exhaustive mixed-mode quantitative survey was conducted among key participants in the South African infrastructure sector. Public sector clients, consulting engineers and contractors that were involved in civil engineering projects were surveyed repeatedly with approximately five survey instruments at convenient intervals. Results arising from the study, inter-alia, indicate that: an appreciable amount of NVAAs occur in South African construction; these NVAAs become further compounded when propagated into other value adding activities (VAAs) in the construction process; the identified NVAAs equally perpetrate the menace associated with poor performance to the detriment of the achievement of cost, H&S, quality, and time project targets, and the root cause of these NVAAs that often contribute to poor performance is not far from the much reported „shortage of skills‟ in South Africa. Notable contributions to the body of knowledge include SD models are extendable regardless of the source of their empirical data as evident in the qualitative models proposed in this study; within the SD domain, it is advisable to consider the „competence‟ of individuals assigned to tasks especially in a developing country as this study revealed that human resources issues predominate among the sources of NVAAs that eventuate in a range of poor project performance; the NVAAs that occur, and their causes on projects are perceived to be due to lapses and / or inadequacies that involved the entire construction supply chain; there is no single construction process / task that is immune from being affected by NVAAs; and within the South African, and by implication construction context generally iii in developing countries, the adequacy of required knowledge among project stakeholders is the most crucial determinant of project performance. As opposed to what is obtainable in developed countries, the construction industry in developing countries, particularly in South Africa, should take advantage of knowledge management (KM) techniques such as brainstorming, communities of practices, and face-to-face interactions. These techniques can be driven through appropriate mentorship programmes, industry focused built environment education, and other human resources driven avenues that do not necessarily require substantial investment in technologies, so that to a large extent organisations in the industry can prioritise KM, and thereafter, continually engage in it for future performance improvement. Using inferential statistical methods for hypotheses testing, and SD concepts for creating qualitative models led to a range of recommendations which, inter-alia, propose that halting the tide of NVAAs and poor performance requires the management of both tacit and explicit knowledge gained in construction; and most importantly, it requires the assurance that „competence‟ is the overriding criteria for selecting project partners, and also, for assigning either design or construction related activities to responsible parties involved in project realisation in South Africa. In effect, in order to engender a culture of continuous improvement in South African construction, other considerations should be subservient to „competence‟ in the construction supply chain. Competence must be located among everyone involved in project realisation, that is, enhancing the competence of all involved in project realisation is as good as ensuring performance improvement, which in turn, equates to the acceleration of project delivery in South Africa.
- Full Text:
- Date Issued: 2011
- Authors: Emuze, Fidelis Abumere
- Date: 2011
- Subjects: Construction industry -- South Africa -- Management , Project management -- South Africa , Construction projects -- Management , Business logistics -- South Africa -- Management
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:9678 , http://hdl.handle.net/10948/1642 , Construction industry -- South Africa -- Management , Project management -- South Africa , Construction projects -- Management , Business logistics -- South Africa -- Management
- Description: In general, dreams are conceived, ideas are conceptualised, and initiatives are embarked upon in order to alter the state of realities. Dreams change realities; when mechanisms are put in place to realise them, dreams succeed. However, anecdotal evidence as well as empirical findings has continued to reiterate the difficulties associated with realising dreams related to construction projects. Extending the „dream‟ analogy to the South African construction industry context therefore paints an uninspiring picture. Dreams associated with construction do not have a 100% chance of becoming realities as evident in reported poor project performance in the industry. Shattered dreams in the form of poor performing projects, poorly implemented construction processes, or worst, projects delivered at the expense of unexpected cost to the client as a direct result of poor H&S or time overruns, negate the intent of dreams. This thesis is primarily concerned with project performance related bottlenecks in South African construction. After an extensive review of related literature that entails the analysis of publications related to non-value adding activities (NVAAs), supply chain management (SCM), and system dynamics (SD) in the construction project management realm, an exhaustive mixed-mode quantitative survey was conducted among key participants in the South African infrastructure sector. Public sector clients, consulting engineers and contractors that were involved in civil engineering projects were surveyed repeatedly with approximately five survey instruments at convenient intervals. Results arising from the study, inter-alia, indicate that: an appreciable amount of NVAAs occur in South African construction; these NVAAs become further compounded when propagated into other value adding activities (VAAs) in the construction process; the identified NVAAs equally perpetrate the menace associated with poor performance to the detriment of the achievement of cost, H&S, quality, and time project targets, and the root cause of these NVAAs that often contribute to poor performance is not far from the much reported „shortage of skills‟ in South Africa. Notable contributions to the body of knowledge include SD models are extendable regardless of the source of their empirical data as evident in the qualitative models proposed in this study; within the SD domain, it is advisable to consider the „competence‟ of individuals assigned to tasks especially in a developing country as this study revealed that human resources issues predominate among the sources of NVAAs that eventuate in a range of poor project performance; the NVAAs that occur, and their causes on projects are perceived to be due to lapses and / or inadequacies that involved the entire construction supply chain; there is no single construction process / task that is immune from being affected by NVAAs; and within the South African, and by implication construction context generally iii in developing countries, the adequacy of required knowledge among project stakeholders is the most crucial determinant of project performance. As opposed to what is obtainable in developed countries, the construction industry in developing countries, particularly in South Africa, should take advantage of knowledge management (KM) techniques such as brainstorming, communities of practices, and face-to-face interactions. These techniques can be driven through appropriate mentorship programmes, industry focused built environment education, and other human resources driven avenues that do not necessarily require substantial investment in technologies, so that to a large extent organisations in the industry can prioritise KM, and thereafter, continually engage in it for future performance improvement. Using inferential statistical methods for hypotheses testing, and SD concepts for creating qualitative models led to a range of recommendations which, inter-alia, propose that halting the tide of NVAAs and poor performance requires the management of both tacit and explicit knowledge gained in construction; and most importantly, it requires the assurance that „competence‟ is the overriding criteria for selecting project partners, and also, for assigning either design or construction related activities to responsible parties involved in project realisation in South Africa. In effect, in order to engender a culture of continuous improvement in South African construction, other considerations should be subservient to „competence‟ in the construction supply chain. Competence must be located among everyone involved in project realisation, that is, enhancing the competence of all involved in project realisation is as good as ensuring performance improvement, which in turn, equates to the acceleration of project delivery in South Africa.
- Full Text:
- Date Issued: 2011
Synthesis and electrochemical properties of new tetra substituted cobalt phthalocyanine complexes, and their application in electrode modification for the electrocatalysis of l-cysteine
- Erdoğmuş, Ali, Booysen, Irvin Noel, Nyokong, Tebello
- Authors: Erdoğmuş, Ali , Booysen, Irvin Noel , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247893 , vital:51627 , xlink:href="https://doi.org/10.1016/j.synthmet.2010.11.028"
- Description: This study investigates the synthesis and characterization new peripherally (β) tetra-substituted 4-(2-mercaptoquinoline phthalocyaninato) Co(II) (CoPcSHQn, 3), and 4-(2-phenoxy-4-trifluoromethylpyridine phthalocyaninato) Co(II) (CoPcOHPy, 4). These complexes were characterized by elemental analysis, IR, mass and electronic spectroscopies and electrochemical methods. Both complexes show well resolved redox peaks attributed to both ring and metal based processes. Spectroelectrochemistry was used to confirm the assignments of the redox processes. For CoPcSHQn (3): CoIPc−2/CoIPc−3 (E1/2 = −1.25 V, I), CoIIPc−2/CoIPc−2 (E1/2 = −0.57 V, II), CoIIIPc−2/CoIIPc−2 (E1/2 = +0.45 V, IV) and an irreversible process at Ep = +1.05 V vs Ag|AgCl for CoIIIPc−1/CoIIIPc−2 (V). Redox couple III at E1/2 = −0.15 V was ascribed to aggregation. In the case of CoPcOHPy (4): CoIPc−2/CoIPc−3 (E1/2 = −1.13 V, I), CoIIPc−2/CoIPc−2 (E1/2 = −0.45 V, II), CoIIIPc−2/CoIIPc−2 at E1/2 = +0.21 V (IV), and CoIIIPc−1/CoIIIPc−2 (E1/2 = +1.01 V vs Ag|AgCl, V). Again III is associated with the aggregated species. Both complexes were electrodeposited on a glassy carbon electrode (GCE). For complex 3 self-assembled monolayers was also formed. The modified (CoPc-GCE) electrodes electrocatalytically detected L-cysteine at Ep = 0.62 V (3-GCE) and 0.59 V (4-GCE) vs Ag|AgCl.
- Full Text:
- Date Issued: 2011
- Authors: Erdoğmuş, Ali , Booysen, Irvin Noel , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247893 , vital:51627 , xlink:href="https://doi.org/10.1016/j.synthmet.2010.11.028"
- Description: This study investigates the synthesis and characterization new peripherally (β) tetra-substituted 4-(2-mercaptoquinoline phthalocyaninato) Co(II) (CoPcSHQn, 3), and 4-(2-phenoxy-4-trifluoromethylpyridine phthalocyaninato) Co(II) (CoPcOHPy, 4). These complexes were characterized by elemental analysis, IR, mass and electronic spectroscopies and electrochemical methods. Both complexes show well resolved redox peaks attributed to both ring and metal based processes. Spectroelectrochemistry was used to confirm the assignments of the redox processes. For CoPcSHQn (3): CoIPc−2/CoIPc−3 (E1/2 = −1.25 V, I), CoIIPc−2/CoIPc−2 (E1/2 = −0.57 V, II), CoIIIPc−2/CoIIPc−2 (E1/2 = +0.45 V, IV) and an irreversible process at Ep = +1.05 V vs Ag|AgCl for CoIIIPc−1/CoIIIPc−2 (V). Redox couple III at E1/2 = −0.15 V was ascribed to aggregation. In the case of CoPcOHPy (4): CoIPc−2/CoIPc−3 (E1/2 = −1.13 V, I), CoIIPc−2/CoIPc−2 (E1/2 = −0.45 V, II), CoIIIPc−2/CoIIPc−2 at E1/2 = +0.21 V (IV), and CoIIIPc−1/CoIIIPc−2 (E1/2 = +1.01 V vs Ag|AgCl, V). Again III is associated with the aggregated species. Both complexes were electrodeposited on a glassy carbon electrode (GCE). For complex 3 self-assembled monolayers was also formed. The modified (CoPc-GCE) electrodes electrocatalytically detected L-cysteine at Ep = 0.62 V (3-GCE) and 0.59 V (4-GCE) vs Ag|AgCl.
- Full Text:
- Date Issued: 2011
An evaluation of the feasibility of obtaining payment for ecosystem services for the Baviaanskloof Nature Reserve
- Authors: Erlank, Wayne Michael
- Date: 2011
- Subjects: Ecosystem services -- South Africa -- Eastern Cape Ecology -- Economic aspects -- South Africa -- Eastern Cape Environmental economics -- South Africa -- Eastern Cape Water-supply -- South Africa -- Eastern Cape Water-supply -- South Africa -- Eastern Cape -- Management Water resources development -- South Africa -- Eastern Cape Nature conservation -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:742 , http://hdl.handle.net/10962/d1003862
- Description: Cities must go further and further away to find new, more costly sources of water for human consumption while industries and agriculture continue to compete for increasingly scarce water resources. This may already be seen occurring within the Nelson Mandela Bay Metro where the severe drought being experienced during the past 18 months has severely depleted water supply dams. One of the main supply dams to the Nelson Mandela Bay Municipality is situated within the Baviaanskloof Nature Reserve and World Heritage Site. The potential of funding the Baviaanskloof Nature Reserve and World Heritage Site with payments for ecosystem services (water) obtained for water services supplied to the Nelson Mandela Bay Municipalities and agriculture in the Gamtoos River Valley will ensure financial sustainable for the Baviaanskloof Nature Reserve and World Heritage Site in the long term. This ability to become financially independent and generate its own income will place the Baviaanskloof Nature Reserve and World Heritage Site in a unique position within the conservation community in South Africa as only a very few protected areas are self sustaining through payment for an ecosystem service.
- Full Text:
- Date Issued: 2011
- Authors: Erlank, Wayne Michael
- Date: 2011
- Subjects: Ecosystem services -- South Africa -- Eastern Cape Ecology -- Economic aspects -- South Africa -- Eastern Cape Environmental economics -- South Africa -- Eastern Cape Water-supply -- South Africa -- Eastern Cape Water-supply -- South Africa -- Eastern Cape -- Management Water resources development -- South Africa -- Eastern Cape Nature conservation -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:742 , http://hdl.handle.net/10962/d1003862
- Description: Cities must go further and further away to find new, more costly sources of water for human consumption while industries and agriculture continue to compete for increasingly scarce water resources. This may already be seen occurring within the Nelson Mandela Bay Metro where the severe drought being experienced during the past 18 months has severely depleted water supply dams. One of the main supply dams to the Nelson Mandela Bay Municipality is situated within the Baviaanskloof Nature Reserve and World Heritage Site. The potential of funding the Baviaanskloof Nature Reserve and World Heritage Site with payments for ecosystem services (water) obtained for water services supplied to the Nelson Mandela Bay Municipalities and agriculture in the Gamtoos River Valley will ensure financial sustainable for the Baviaanskloof Nature Reserve and World Heritage Site in the long term. This ability to become financially independent and generate its own income will place the Baviaanskloof Nature Reserve and World Heritage Site in a unique position within the conservation community in South Africa as only a very few protected areas are self sustaining through payment for an ecosystem service.
- Full Text:
- Date Issued: 2011
South African money market volatility, asymmetry and retail interest pass-through
- Authors: Fadiran, Gideon Oluwatobi
- Date: 2011
- Subjects: Money market -- South Africa Interest rates -- South Africa Monetary policy -- South Africa Econometric models Banks and banking -- South Africa
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:993 , http://hdl.handle.net/10962/d1002728
- Description: The purpose of this paper is to examine the interest rate transmission mechanism for South Africa as an emerging economy in a pre-repo and repo system. It explains how the money market rate is transmitted to the retail interest rates both in the long-run and short-run and tests the symmetric and asymmetric interest rate pass-through using the Scholnick (1996) ECM and the Wang and Lee (2009) ECM-EGARCH (1, 1)-M methodology. This permitted the examination of the impact of interest rate volatility, along with the leverage effect. An incomplete pass-through is found in the short-run. From the entire sample period, a symmetric adjustment is found in the deposit rate, which had upward rigidity adjustment, while an asymmetric adjustment is found in the lending rate, with a downward rigidity adjustment. All the adjustments supported the collusive pricing arrangements. According to the conditional variance estimation of the ECM-EGARCH (1, 1), negative volatility impact and leverage effect are present and influential only in the deposit interest rate adjustment process in South Africa.
- Full Text:
- Date Issued: 2011
- Authors: Fadiran, Gideon Oluwatobi
- Date: 2011
- Subjects: Money market -- South Africa Interest rates -- South Africa Monetary policy -- South Africa Econometric models Banks and banking -- South Africa
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:993 , http://hdl.handle.net/10962/d1002728
- Description: The purpose of this paper is to examine the interest rate transmission mechanism for South Africa as an emerging economy in a pre-repo and repo system. It explains how the money market rate is transmitted to the retail interest rates both in the long-run and short-run and tests the symmetric and asymmetric interest rate pass-through using the Scholnick (1996) ECM and the Wang and Lee (2009) ECM-EGARCH (1, 1)-M methodology. This permitted the examination of the impact of interest rate volatility, along with the leverage effect. An incomplete pass-through is found in the short-run. From the entire sample period, a symmetric adjustment is found in the deposit rate, which had upward rigidity adjustment, while an asymmetric adjustment is found in the lending rate, with a downward rigidity adjustment. All the adjustments supported the collusive pricing arrangements. According to the conditional variance estimation of the ECM-EGARCH (1, 1), negative volatility impact and leverage effect are present and influential only in the deposit interest rate adjustment process in South Africa.
- Full Text:
- Date Issued: 2011
In vitro drug-herb interaction potential of African medicinal plant products used by Type II diabetics
- Authors: Fang, Yuan Yuan
- Date: 2011
- Subjects: Materia medica, Vegetable -- South Africa , Drugs -- Therapeutic use , Drug-herb interactions -- South Africa , Non-insulin-dependent diabetes -- South Africa , Non-insulin-dependent diabetes -- Treatment -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10317 , http://hdl.handle.net/10948/1341 , Materia medica, Vegetable -- South Africa , Drugs -- Therapeutic use , Drug-herb interactions -- South Africa , Non-insulin-dependent diabetes -- South Africa , Non-insulin-dependent diabetes -- Treatment -- South Africa
- Description: In Africa, use of medicinal plants for the treatment of diabetes is very common. However, efficacy on co-administering of medicinal plants with therapeutic drugs hasn't been fully determined, especially for African medicinal plants. The current study focused on assessing the in vitro modulation effects of three popular African medicinal plants, namely: Aloe ferox, Sutherlandia frutescens and Prunus africana (including five commercial preparations containing these medicinal plants) on two of the most important anti-diabetic drug metabolising enzymes, Cytochrome P450 (CYP450) 2C9 and CYP3A4 and a key drug efflux transporter, P-glycoprotein (P-gp). Vivid® microsome-based screening kits were used to assess inhibitory potency of plants preparations on CYP2C9 and CYP3A4 enzymes activities. The study showed that P. africana was a more potent inhibitor of CYP2C9 and CYP3A4 activity than the corresponding positive controls Ginkgo biloba and St. John's wort, which are known to cause clinically significant drug-herb interactions. S. frutescens leaf extract demonstrated potent to moderate inhibition on both the tested CYP activities, while its commercial products (Promune® and Probetix®) possessed moderate to mild inhibitory effects on the activities of both CYPs. Potent inhibitory effect on CYP2C9 and CYP3A4 was seen with Aloe Ferox®. Prosit® and Aloes powder® showed potent to moderate inhibition on CYP2C9 activity and moderate to mild inhibition on CYP3A4 activity. In addition to CYP450 activity, the present study also investigated the effects of the selected medicinal plant products on the activity of the main drug efflux protein, P-gp. A screening assay was specifically developed to assess the potential for herbal remedies to interact with P-gp mediated drug absorption. The assay is based on the principle of the reversal of drug resistance in modified Caco-2 cells specifically altered to express high iv efflux protein activity. These cells display a multidrug resistance phenotype and the addition of a plant extract containing a P-gp inhibitor or substrate will inhibit or compete with any cytotoxic drug and consequently reverse the drug resistance. The suitability of the assay was confirmed using a known P-gp inhibitor. The study observed that the anti-proliferation effect of vinblastine was significantly enhanced in vinblastine-resistant Caco-2 cells, which have high P-gp expression, when they were exposed to the selected African herbal preparations. This observation indicates that the studied plant preparations may alter P-gp functionality and therefore lead to interference with the absorption of co-administered drugs. The outcomes of this study provide useful information on whether there are any potential drug-herb interactions between the commonly used African medicinal plants and oral anti-diabetic drugs, at the level of CYP and P-gp drug metabolism and could contribute to better therapeutic management of Type II diabetics. However these predicted interactions will need to be verified in a clinical setting.
- Full Text:
- Date Issued: 2011
- Authors: Fang, Yuan Yuan
- Date: 2011
- Subjects: Materia medica, Vegetable -- South Africa , Drugs -- Therapeutic use , Drug-herb interactions -- South Africa , Non-insulin-dependent diabetes -- South Africa , Non-insulin-dependent diabetes -- Treatment -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10317 , http://hdl.handle.net/10948/1341 , Materia medica, Vegetable -- South Africa , Drugs -- Therapeutic use , Drug-herb interactions -- South Africa , Non-insulin-dependent diabetes -- South Africa , Non-insulin-dependent diabetes -- Treatment -- South Africa
- Description: In Africa, use of medicinal plants for the treatment of diabetes is very common. However, efficacy on co-administering of medicinal plants with therapeutic drugs hasn't been fully determined, especially for African medicinal plants. The current study focused on assessing the in vitro modulation effects of three popular African medicinal plants, namely: Aloe ferox, Sutherlandia frutescens and Prunus africana (including five commercial preparations containing these medicinal plants) on two of the most important anti-diabetic drug metabolising enzymes, Cytochrome P450 (CYP450) 2C9 and CYP3A4 and a key drug efflux transporter, P-glycoprotein (P-gp). Vivid® microsome-based screening kits were used to assess inhibitory potency of plants preparations on CYP2C9 and CYP3A4 enzymes activities. The study showed that P. africana was a more potent inhibitor of CYP2C9 and CYP3A4 activity than the corresponding positive controls Ginkgo biloba and St. John's wort, which are known to cause clinically significant drug-herb interactions. S. frutescens leaf extract demonstrated potent to moderate inhibition on both the tested CYP activities, while its commercial products (Promune® and Probetix®) possessed moderate to mild inhibitory effects on the activities of both CYPs. Potent inhibitory effect on CYP2C9 and CYP3A4 was seen with Aloe Ferox®. Prosit® and Aloes powder® showed potent to moderate inhibition on CYP2C9 activity and moderate to mild inhibition on CYP3A4 activity. In addition to CYP450 activity, the present study also investigated the effects of the selected medicinal plant products on the activity of the main drug efflux protein, P-gp. A screening assay was specifically developed to assess the potential for herbal remedies to interact with P-gp mediated drug absorption. The assay is based on the principle of the reversal of drug resistance in modified Caco-2 cells specifically altered to express high iv efflux protein activity. These cells display a multidrug resistance phenotype and the addition of a plant extract containing a P-gp inhibitor or substrate will inhibit or compete with any cytotoxic drug and consequently reverse the drug resistance. The suitability of the assay was confirmed using a known P-gp inhibitor. The study observed that the anti-proliferation effect of vinblastine was significantly enhanced in vinblastine-resistant Caco-2 cells, which have high P-gp expression, when they were exposed to the selected African herbal preparations. This observation indicates that the studied plant preparations may alter P-gp functionality and therefore lead to interference with the absorption of co-administered drugs. The outcomes of this study provide useful information on whether there are any potential drug-herb interactions between the commonly used African medicinal plants and oral anti-diabetic drugs, at the level of CYP and P-gp drug metabolism and could contribute to better therapeutic management of Type II diabetics. However these predicted interactions will need to be verified in a clinical setting.
- Full Text:
- Date Issued: 2011
Development, manufacture and assessment of Clobetasol 17-propionate cream formulations
- Fauzee, Ayeshah Fateemah Beebee
- Authors: Fauzee, Ayeshah Fateemah Beebee
- Date: 2011
- Subjects: Adrenocortical hormones , Adrenocortical hormones -- Physiological effect , Adrenocortical hormones -- Testing , Drugs -- Testing , Drugs -- Development , Dermatopharmacology
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3856 , http://hdl.handle.net/10962/d1013324
- Description: Eczema or dermatitis is the most common dermatological condition accounting for one-third of all diagnoses in the total population surveyed in South Africa. The prevalence of seborrhoeic dermatitis, extreme photodermatitis and severe psoriasis has increased markedly over the last decade and this increase may be ascribed to the HIV epidemic, first diagnosed in South Africa in 1982. Potent innovator corticosteroids, such as clobetasol 17-propionate (CP) that are used to treat skin disorders, are expensive and there is therefore a need for the production of generic topical corticosteroid products. Formulation and manufacturing processes can be challenging aspects for formulation scientists to produce a robust product that will elicit an appropriate and desirable pharmacokinetic-pharmacodynamic profile. Laboratory scale CP creams were manufactured using different concentrations of Gelot® 64 and propylene glycol in order to establish a composition that would produce a formulation, with similar physical and chemical characteristics and in vitro release profile as an innovator product, Dermovate®. These formulations were assessed in terms of their viscosity, spreadability, pH, content uniformity and in vitro release characteristics using a Franz diffusion cell apparatus. A formulation containing 3% w/w Gelot® 64 and 46% v/v propylene glycol (CPLS-02) was found to exhibit similar viscosity and spreadability characteristics and released CP in a manner similar to Dermovate®. The mechanism of drug release was evaluated using mathematical models such as zero order, first order and Higuchi models. In addition, the in vitro release profiles were characterised by use of difference (f1) and similarity (f2 and Sd) factors. A scale-up formulation with the same % w/w composition as the laboratory scale was also investigated following manufacture using a Wintech® cream/ointment mixer. A Central Composite Design approach was used to investigate the effect of process variables on the performance of the scale-up cream formulations. The homogenisation speed, anchor speed, homogenisation time and cooling time were the process variables investigated. Thirty scale-up batches were manufactured and analysed in terms of their viscosity, spreadability, pH, % drug content and cumulative % drug released per unit area over 72 hours. Model fitting using Design-Expert® software was undertaken and revealed that a correlation between the process variables and the cream responses was most suitably described by quadratic polynomial relationships. The homogenisation speed had the most significant effect on the quality of the scale-up formulations, whereas the anchor speed had a secondary effect on the measured responses, for the formulations investigated. The qualitative interpretation and statistical analysis of the in vitro release data from the scale-up formulations using ANOVA and the f1, f2 and Sd factors revealed that one scale-up batch (CPSU-04), for which the process variables were a homogenisation speed of 1900 rpm, an anchor speed of 35 rpm, a homogenisation time of 100 minutes and a cooling time of 100 minutes, released CP at a similar rate and extent to Dermovate®. A diffusion-controlled mechanism appeared to be predominant in these formulations. A human skin blanching study, using both visual and chromameter assessments, was performed to establish whether batch CPSU-04 was bioequivalent to Dermovate®. The bioequivalence of the selected scale-up formulation to Dermovate® was confirmed, following the calculation of a 90% CI.
- Full Text:
- Date Issued: 2011
- Authors: Fauzee, Ayeshah Fateemah Beebee
- Date: 2011
- Subjects: Adrenocortical hormones , Adrenocortical hormones -- Physiological effect , Adrenocortical hormones -- Testing , Drugs -- Testing , Drugs -- Development , Dermatopharmacology
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3856 , http://hdl.handle.net/10962/d1013324
- Description: Eczema or dermatitis is the most common dermatological condition accounting for one-third of all diagnoses in the total population surveyed in South Africa. The prevalence of seborrhoeic dermatitis, extreme photodermatitis and severe psoriasis has increased markedly over the last decade and this increase may be ascribed to the HIV epidemic, first diagnosed in South Africa in 1982. Potent innovator corticosteroids, such as clobetasol 17-propionate (CP) that are used to treat skin disorders, are expensive and there is therefore a need for the production of generic topical corticosteroid products. Formulation and manufacturing processes can be challenging aspects for formulation scientists to produce a robust product that will elicit an appropriate and desirable pharmacokinetic-pharmacodynamic profile. Laboratory scale CP creams were manufactured using different concentrations of Gelot® 64 and propylene glycol in order to establish a composition that would produce a formulation, with similar physical and chemical characteristics and in vitro release profile as an innovator product, Dermovate®. These formulations were assessed in terms of their viscosity, spreadability, pH, content uniformity and in vitro release characteristics using a Franz diffusion cell apparatus. A formulation containing 3% w/w Gelot® 64 and 46% v/v propylene glycol (CPLS-02) was found to exhibit similar viscosity and spreadability characteristics and released CP in a manner similar to Dermovate®. The mechanism of drug release was evaluated using mathematical models such as zero order, first order and Higuchi models. In addition, the in vitro release profiles were characterised by use of difference (f1) and similarity (f2 and Sd) factors. A scale-up formulation with the same % w/w composition as the laboratory scale was also investigated following manufacture using a Wintech® cream/ointment mixer. A Central Composite Design approach was used to investigate the effect of process variables on the performance of the scale-up cream formulations. The homogenisation speed, anchor speed, homogenisation time and cooling time were the process variables investigated. Thirty scale-up batches were manufactured and analysed in terms of their viscosity, spreadability, pH, % drug content and cumulative % drug released per unit area over 72 hours. Model fitting using Design-Expert® software was undertaken and revealed that a correlation between the process variables and the cream responses was most suitably described by quadratic polynomial relationships. The homogenisation speed had the most significant effect on the quality of the scale-up formulations, whereas the anchor speed had a secondary effect on the measured responses, for the formulations investigated. The qualitative interpretation and statistical analysis of the in vitro release data from the scale-up formulations using ANOVA and the f1, f2 and Sd factors revealed that one scale-up batch (CPSU-04), for which the process variables were a homogenisation speed of 1900 rpm, an anchor speed of 35 rpm, a homogenisation time of 100 minutes and a cooling time of 100 minutes, released CP at a similar rate and extent to Dermovate®. A diffusion-controlled mechanism appeared to be predominant in these formulations. A human skin blanching study, using both visual and chromameter assessments, was performed to establish whether batch CPSU-04 was bioequivalent to Dermovate®. The bioequivalence of the selected scale-up formulation to Dermovate® was confirmed, following the calculation of a 90% CI.
- Full Text:
- Date Issued: 2011
The genetic diversity and conservation biology of the rare terrestrial snail genus Prestonella
- Authors: Fearon, Janine Lee
- Date: 2011
- Subjects: Snails -- South Africa , Snails -- Conservation -- South Africa , Snails -- Variation -- South Africa , Biodiversity -- South Africa , Snails -- Genetics -- South Africa , Snails -- Habitat -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4191 , http://hdl.handle.net/10962/d1003760 , Snails -- South Africa , Snails -- Conservation -- South Africa , Snails -- Variation -- South Africa , Biodiversity -- South Africa , Snails -- Genetics -- South Africa , Snails -- Habitat -- South Africa
- Description: Prestonella bowkeri and Prestonella nuptialis are montane specialists endemic to the southern Great Escarpment of South Africa. Phylogeographic analyses of these species based on mitochondrial markers CO1 and 16S reveal extremely high levels of divergence between populations indicating a lack of gene flow between populations. This is not surprising, because P. nuptialis and P. bowkeri have limited dispersal capacity, low vagility, a highly fragmented distribution and are habitat specialists that are restricted to isolated mesic refugia associated with waterfalls and montane seepages. A relaxed Bayesian clock estimate suggests that populations diverged from one another during the mid-late Miocene (12.5-7 MYA) which coincides with the modern trends of seasonal aridity which began during the Miocene. This result should be viewed with caution because the rates used are at best imprecise estimates of mutation rates in snails. There is no clear dichotomy between the two species and P. bowkeri is paraphyletic with respect to P. nuptialis, as a consequence the taxonomy is unclear. Due to the high levels of sequence divergence between populations they may be considered as evolutionary significant units (ESU’s). An assessment of haplotype diversity (h) and nucleotide diversity (π) reveals that populations in the western part of the Great Escarpment are more genetically depauperate than populations in the east. Correlations between genetic diversity and climatic variables show that genetically depauperate populations are found in areas that have lower annual rainfall, less reliable rainfall and higher potential evaporation, all factors associated with a drier, less mesic environment that increases the chances of a population bottleneck. This indicates that a shift towards a more arid environment may be a driver of genetic erosion. Historical climate change may thus have affected the amount and distribution of genetic diversity across the Great Escarpment since the Miocene. This has serious future implications for the survival of Prestonella. With predicted increase in global temperatures, climate change in South Africa is likely to result in range contraction and an eastward range shift for many species in the drier central and western areas (Erasmus et al. 2002) and regions along the Great Escarpment are likely to become more arid. Prestonella populations found living on inselbergs along the Great Escarpment are already restricted to site specific watercourses and seepages. An increase in the periods between stream flow, and increasing rainfall variability and mean annual potential evaporation are likely to have an adverse affect on species living in these habitats, resulting in further bottlenecks and possibly local extinction. An IUCN assessment of P. nuptialis and P. bowkeri suggests that these two species are probably endangered. The issue surrounding the conservation of Prestonella species is that they are threatened by global climate change, which cannot be simply restricted or prevented, which makes dealing with the threat of climate change difficult. Assisted migration (MA) may be considered as a method to prevent possible future extinctions of Prestonella populations, but will only be considered as a last resort. The thermal tolerance (Arrhenius breaking temperature and flat-line temperature) of individual snails from three Prestonella populations (one forest population and two thicket populations) were assessed using infrared sensors that detected changes in heart rate with increasing temperature. The forest population had a significantly lower Arrhenius breaking temperature (ABT) and flat-line temperature (FLT) than the two thicket population (p<0.05). Our results do not show a correlation between upper thermal limits and maximum habitat temperatures or other climatic variables in Prestonella populations. Although no correlation is found between ABT and maximum habitat temperature, it is likely that the differences seen between these populations are due to local micro-climate adaptation. The climatic variables used in this experiment are coarse estimates from GIS data and do not reflect actual microhabitat conditions. Forest environments are less heat stressed than thicket environments due to the forest canopy which may explain the lower ABT and FLT of the forest population.
- Full Text:
- Date Issued: 2011
- Authors: Fearon, Janine Lee
- Date: 2011
- Subjects: Snails -- South Africa , Snails -- Conservation -- South Africa , Snails -- Variation -- South Africa , Biodiversity -- South Africa , Snails -- Genetics -- South Africa , Snails -- Habitat -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4191 , http://hdl.handle.net/10962/d1003760 , Snails -- South Africa , Snails -- Conservation -- South Africa , Snails -- Variation -- South Africa , Biodiversity -- South Africa , Snails -- Genetics -- South Africa , Snails -- Habitat -- South Africa
- Description: Prestonella bowkeri and Prestonella nuptialis are montane specialists endemic to the southern Great Escarpment of South Africa. Phylogeographic analyses of these species based on mitochondrial markers CO1 and 16S reveal extremely high levels of divergence between populations indicating a lack of gene flow between populations. This is not surprising, because P. nuptialis and P. bowkeri have limited dispersal capacity, low vagility, a highly fragmented distribution and are habitat specialists that are restricted to isolated mesic refugia associated with waterfalls and montane seepages. A relaxed Bayesian clock estimate suggests that populations diverged from one another during the mid-late Miocene (12.5-7 MYA) which coincides with the modern trends of seasonal aridity which began during the Miocene. This result should be viewed with caution because the rates used are at best imprecise estimates of mutation rates in snails. There is no clear dichotomy between the two species and P. bowkeri is paraphyletic with respect to P. nuptialis, as a consequence the taxonomy is unclear. Due to the high levels of sequence divergence between populations they may be considered as evolutionary significant units (ESU’s). An assessment of haplotype diversity (h) and nucleotide diversity (π) reveals that populations in the western part of the Great Escarpment are more genetically depauperate than populations in the east. Correlations between genetic diversity and climatic variables show that genetically depauperate populations are found in areas that have lower annual rainfall, less reliable rainfall and higher potential evaporation, all factors associated with a drier, less mesic environment that increases the chances of a population bottleneck. This indicates that a shift towards a more arid environment may be a driver of genetic erosion. Historical climate change may thus have affected the amount and distribution of genetic diversity across the Great Escarpment since the Miocene. This has serious future implications for the survival of Prestonella. With predicted increase in global temperatures, climate change in South Africa is likely to result in range contraction and an eastward range shift for many species in the drier central and western areas (Erasmus et al. 2002) and regions along the Great Escarpment are likely to become more arid. Prestonella populations found living on inselbergs along the Great Escarpment are already restricted to site specific watercourses and seepages. An increase in the periods between stream flow, and increasing rainfall variability and mean annual potential evaporation are likely to have an adverse affect on species living in these habitats, resulting in further bottlenecks and possibly local extinction. An IUCN assessment of P. nuptialis and P. bowkeri suggests that these two species are probably endangered. The issue surrounding the conservation of Prestonella species is that they are threatened by global climate change, which cannot be simply restricted or prevented, which makes dealing with the threat of climate change difficult. Assisted migration (MA) may be considered as a method to prevent possible future extinctions of Prestonella populations, but will only be considered as a last resort. The thermal tolerance (Arrhenius breaking temperature and flat-line temperature) of individual snails from three Prestonella populations (one forest population and two thicket populations) were assessed using infrared sensors that detected changes in heart rate with increasing temperature. The forest population had a significantly lower Arrhenius breaking temperature (ABT) and flat-line temperature (FLT) than the two thicket population (p<0.05). Our results do not show a correlation between upper thermal limits and maximum habitat temperatures or other climatic variables in Prestonella populations. Although no correlation is found between ABT and maximum habitat temperature, it is likely that the differences seen between these populations are due to local micro-climate adaptation. The climatic variables used in this experiment are coarse estimates from GIS data and do not reflect actual microhabitat conditions. Forest environments are less heat stressed than thicket environments due to the forest canopy which may explain the lower ABT and FLT of the forest population.
- Full Text:
- Date Issued: 2011
Population assessments of priority plant species used by local communities in and around three Wild Coast reserves, Eastern Cape, South Africa
- Authors: Fearon, Joclyn Joe
- Date: 2011
- Subjects: Plant diversity conservation -- South Africa -- Eastern Cape , Rare plants -- South Africa -- Eastern Cape -- Population viability analysis , Biodiversity -- South Africa -- Eastern Cape , Plant conservation -- South Africa -- Eastern Cape , Conservation of natural resources -- South Africa -- Eastern Cape , Human-plant relationships -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4751 , http://hdl.handle.net/10962/d1007059 , Plant diversity conservation -- South Africa -- Eastern Cape , Rare plants -- South Africa -- Eastern Cape -- Population viability analysis , Biodiversity -- South Africa -- Eastern Cape , Plant conservation -- South Africa -- Eastern Cape , Conservation of natural resources -- South Africa -- Eastern Cape , Human-plant relationships -- South Africa -- Eastern Cape
- Description: The project was initiated by Eastern Cape Parks (ECP) as a request for the construction of inventories of priority species and their population levels inside three nature reserves on the Eastern Cape Wild Coast, South Africa, and to develop a strategic management plan to manage these natural resources in each reserve. Thirty key species were identified by local communities in and around Dwesa-Cwebe, Silaka and Mkambati Nature Reserves through community workshops. For forested areas belt transects of 100 m x 6 m where used. The basal circumference of key tree species within the belt transect was measured as well as the height of saplings (height < 150 m). Tree species were categorized based on densities, size class distribution (SCD) curves and values, and spatial grain. For grassland areas straight transects of 200 m long were used, along which ten 3 m x 3 m quadrates were placed at 20 m intervals. Within each grassland transect the height of herbs or tuft diameter of grasses was recorded and percentage cover estimated. Grassland species were categorized based on density, SCD curves and percentage cover. All species were placed into harvesting categories based on analysed ecological data that was collected in the field. Category 1 species were very rare or not found in the reserve and it was recommended that species be conserved and monitored. Category 2 species had low densities in the reserve indicating declining populations and was suggested that these be monitored and not harvested. Category 3 species had high densities and have potential for harvesting with strict limitations. Category 4 species were most abundant with very high densities and can be harvested within management guidelines. These categories were grouped further using social and ecological data such as harvesting risk, frequency of collection, use value and number of uses. This highlighted which species have conservation priority within each category and a decision can be made as to how intense or limited extraction should be. By incorporating GIS the distribution of each species was looked at and harvesting and non-harvesting zones established to determine where species can be extracted. Monitoring plans must consider the quantity of plant material collected, fire regimes, optimal harvesting rates and harvesting zones, and be able to pick up changes in populations. Also, it is important that the community be involved in conserving and monitoring these species. Adaptive monitoring and management must be used to steer harvesting practices in the Wild Coast reserves. This allows for the development of harvesting practices through ‘learning by doing’, and the evolution of good questions to guide monitoring decisions
- Full Text:
- Date Issued: 2011
- Authors: Fearon, Joclyn Joe
- Date: 2011
- Subjects: Plant diversity conservation -- South Africa -- Eastern Cape , Rare plants -- South Africa -- Eastern Cape -- Population viability analysis , Biodiversity -- South Africa -- Eastern Cape , Plant conservation -- South Africa -- Eastern Cape , Conservation of natural resources -- South Africa -- Eastern Cape , Human-plant relationships -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4751 , http://hdl.handle.net/10962/d1007059 , Plant diversity conservation -- South Africa -- Eastern Cape , Rare plants -- South Africa -- Eastern Cape -- Population viability analysis , Biodiversity -- South Africa -- Eastern Cape , Plant conservation -- South Africa -- Eastern Cape , Conservation of natural resources -- South Africa -- Eastern Cape , Human-plant relationships -- South Africa -- Eastern Cape
- Description: The project was initiated by Eastern Cape Parks (ECP) as a request for the construction of inventories of priority species and their population levels inside three nature reserves on the Eastern Cape Wild Coast, South Africa, and to develop a strategic management plan to manage these natural resources in each reserve. Thirty key species were identified by local communities in and around Dwesa-Cwebe, Silaka and Mkambati Nature Reserves through community workshops. For forested areas belt transects of 100 m x 6 m where used. The basal circumference of key tree species within the belt transect was measured as well as the height of saplings (height < 150 m). Tree species were categorized based on densities, size class distribution (SCD) curves and values, and spatial grain. For grassland areas straight transects of 200 m long were used, along which ten 3 m x 3 m quadrates were placed at 20 m intervals. Within each grassland transect the height of herbs or tuft diameter of grasses was recorded and percentage cover estimated. Grassland species were categorized based on density, SCD curves and percentage cover. All species were placed into harvesting categories based on analysed ecological data that was collected in the field. Category 1 species were very rare or not found in the reserve and it was recommended that species be conserved and monitored. Category 2 species had low densities in the reserve indicating declining populations and was suggested that these be monitored and not harvested. Category 3 species had high densities and have potential for harvesting with strict limitations. Category 4 species were most abundant with very high densities and can be harvested within management guidelines. These categories were grouped further using social and ecological data such as harvesting risk, frequency of collection, use value and number of uses. This highlighted which species have conservation priority within each category and a decision can be made as to how intense or limited extraction should be. By incorporating GIS the distribution of each species was looked at and harvesting and non-harvesting zones established to determine where species can be extracted. Monitoring plans must consider the quantity of plant material collected, fire regimes, optimal harvesting rates and harvesting zones, and be able to pick up changes in populations. Also, it is important that the community be involved in conserving and monitoring these species. Adaptive monitoring and management must be used to steer harvesting practices in the Wild Coast reserves. This allows for the development of harvesting practices through ‘learning by doing’, and the evolution of good questions to guide monitoring decisions
- Full Text:
- Date Issued: 2011