Formulating an operational efficient strategy for the national health laboratory services in the Eastern Cape
- Authors: Sizila, Wandile
- Date: 2023-12
- Subjects: Strategic planning , Organizational effectiveness , Success in business
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/65993 , vital:74294
- Description: This treatise presents the formulation of an operational efficient strategy for the National Health Laboratory Services (NHLS) in the Eastern Cape. Operational inefficiency in the NHLS has the potential to delay laboratory results delivery for necessary health intervention, which may have a negative impact on individuals’ health or lead to death. The aim of the study is to highlight inadequacies that may cause poor service delivery and formulate an operational plan for the NHLS in the Eastern Cape. Strategic efficiency is derived from the resource-based and agent theories. Even though there is a difference between service and manufacturing industries, the operational strategic framework can be used in both. A strategic framework is implemented by assessing market requirements and using the top-down or bottom-up approach. To monitor and regulate these strategies, one can utilise, among others, scorecards, corporate social responsibility and risk management. This is a qualitative research study using semi-structured interviews to gather information from 11 participants. The study targeted managers in the NHLS Eastern Cape region, with a non-probability method, as the large number of managers in the entire region made it impossible to do a random study. Furthermore, the data were analysed by the thematic analysis method. The literature review identified six factors that influence public sector efficiency, namely, compliance issues, ethics, financial expense management, resource optimisation, accountability and service delivery. The primary study revealed several inadequacies in the NHLS Eastern Cape, namely, inefficient human resources practices, underutilising technology, ambiguous policies, delayed turnaround time, lack of financial training for management and lack of support from cross-functional departments. In addition, the results of the study warrant the following recommendations: Proper orientation of staff, with modules pertaining not only to their duties and reporting structure but also to the policies of the organisations and conduct; SWOT analyses and surveys could also be used to assess internal staff and external factors that may hinder efficiency; the installation of solar panels for laboratories, starting with the vulnerable labs in remote areas, wireless internet technology, mobile applications and software. The region also needs to practice good corporate governance, update its policies regularly and budget for all operations, including quasi fiscal activities. Lastly, support departments need to comply with an ISO certification. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business School, 2023 , Abstract.
- Full Text: false
- Date Issued: 2022-04
- Date Issued: 2023-12
- Authors: Sizila, Wandile
- Date: 2023-12
- Subjects: Strategic planning , Organizational effectiveness , Success in business
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/65993 , vital:74294
- Description: This treatise presents the formulation of an operational efficient strategy for the National Health Laboratory Services (NHLS) in the Eastern Cape. Operational inefficiency in the NHLS has the potential to delay laboratory results delivery for necessary health intervention, which may have a negative impact on individuals’ health or lead to death. The aim of the study is to highlight inadequacies that may cause poor service delivery and formulate an operational plan for the NHLS in the Eastern Cape. Strategic efficiency is derived from the resource-based and agent theories. Even though there is a difference between service and manufacturing industries, the operational strategic framework can be used in both. A strategic framework is implemented by assessing market requirements and using the top-down or bottom-up approach. To monitor and regulate these strategies, one can utilise, among others, scorecards, corporate social responsibility and risk management. This is a qualitative research study using semi-structured interviews to gather information from 11 participants. The study targeted managers in the NHLS Eastern Cape region, with a non-probability method, as the large number of managers in the entire region made it impossible to do a random study. Furthermore, the data were analysed by the thematic analysis method. The literature review identified six factors that influence public sector efficiency, namely, compliance issues, ethics, financial expense management, resource optimisation, accountability and service delivery. The primary study revealed several inadequacies in the NHLS Eastern Cape, namely, inefficient human resources practices, underutilising technology, ambiguous policies, delayed turnaround time, lack of financial training for management and lack of support from cross-functional departments. In addition, the results of the study warrant the following recommendations: Proper orientation of staff, with modules pertaining not only to their duties and reporting structure but also to the policies of the organisations and conduct; SWOT analyses and surveys could also be used to assess internal staff and external factors that may hinder efficiency; the installation of solar panels for laboratories, starting with the vulnerable labs in remote areas, wireless internet technology, mobile applications and software. The region also needs to practice good corporate governance, update its policies regularly and budget for all operations, including quasi fiscal activities. Lastly, support departments need to comply with an ISO certification. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business School, 2023 , Abstract.
- Full Text: false
- Date Issued: 2022-04
- Date Issued: 2023-12
Quinolone-isoniazid hybrids: Synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation
- Beteck, Richard M, Seldon, Ronnett, Khanye, Setshaba D, Legoabe, Lesetja J, Hoppe, Heinrich C, Laming, Dustin, Jordaan, Audrey, Warner, Digby F
- Authors: Beteck, Richard M , Seldon, Ronnett , Khanye, Setshaba D , Legoabe, Lesetja J , Hoppe, Heinrich C , Laming, Dustin , Jordaan, Audrey , Warner, Digby F
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123151 , vital:35410 , https://doi.org/10.1039/C8MD00480C
- Description: Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached via a hydrazide–hydrazone bond were synthesised and evaluated against Mycobacterium tuberculosis H37Rv (MTB). The compounds were also evaluated for cytotoxicity against HeLa cell lines. These compounds showed significant activity (MIC90) against MTB in the range of 0.2–8 μM without any cytotoxic effects. Compounds 10 (MIC90; 0.9 μM), 11 (MIC90; 0.2 μM), 12 (MIC90; 0.8 μM) and compound 15 (MIC90; 0.8 μM), the most active compounds in this series, demonstrate activities on par with INH and superior to those reported for the fluoroquinolones. The SAR analysis suggests that the nature of substituents at positions −1 and −3 of the quinolone nucleus influences anti-MTB activity. Aqueous solubility evaluation and in vitro metabolic stability of compound 12 highlights favourable drug-like properties for this compound class.
- Full Text:
- Date Issued: 2019
- Authors: Beteck, Richard M , Seldon, Ronnett , Khanye, Setshaba D , Legoabe, Lesetja J , Hoppe, Heinrich C , Laming, Dustin , Jordaan, Audrey , Warner, Digby F
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123151 , vital:35410 , https://doi.org/10.1039/C8MD00480C
- Description: Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached via a hydrazide–hydrazone bond were synthesised and evaluated against Mycobacterium tuberculosis H37Rv (MTB). The compounds were also evaluated for cytotoxicity against HeLa cell lines. These compounds showed significant activity (MIC90) against MTB in the range of 0.2–8 μM without any cytotoxic effects. Compounds 10 (MIC90; 0.9 μM), 11 (MIC90; 0.2 μM), 12 (MIC90; 0.8 μM) and compound 15 (MIC90; 0.8 μM), the most active compounds in this series, demonstrate activities on par with INH and superior to those reported for the fluoroquinolones. The SAR analysis suggests that the nature of substituents at positions −1 and −3 of the quinolone nucleus influences anti-MTB activity. Aqueous solubility evaluation and in vitro metabolic stability of compound 12 highlights favourable drug-like properties for this compound class.
- Full Text:
- Date Issued: 2019
Beneficial effects of medicinal plants in fish diseases
- Stratev, Deyan, Zhelyazkov, Georgi, Noundou, Xavier S, Krause, Rui W M
- Authors: Stratev, Deyan , Zhelyazkov, Georgi , Noundou, Xavier S , Krause, Rui W M
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/126177 , vital:35856 , https://doi.org/10.1007/s10499-017-0219-x
- Description: Fish are constantly in contact with pathogens inhabiting water. High populationdensity as well as poor hydrodynamic conditions and feeding lead to an increased sensitivitytowards infections. In order to prevent major economic losses due to diseases, variousmedications are used for treatment and prevention of infections. The use of antimicrobialdrugs in aquacultures could lead to emergence of resistance in pathogenic microorganisms.Alternatives are being sought over the last few years to replace antibiotics, and medicinalplants are one of available options for this purpose. These plants are rich in secondarymetabolites and phytochemical compounds, which have an effect against viral, bacterial, andparasitic diseases in fish. Their main advantage is their natural origin and most of these plantsdo not represent threat for human health, the fish, and the environment. The goal of this reviewis to present information on the treatment of viral, bacterial, and parasitic diseases in fishthrough medicinal plants, with focus on the mechanisms of action of the identified secondarymetabolites, fractions, or plant extracts.
- Full Text:
- Date Issued: 2018
- Authors: Stratev, Deyan , Zhelyazkov, Georgi , Noundou, Xavier S , Krause, Rui W M
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/126177 , vital:35856 , https://doi.org/10.1007/s10499-017-0219-x
- Description: Fish are constantly in contact with pathogens inhabiting water. High populationdensity as well as poor hydrodynamic conditions and feeding lead to an increased sensitivitytowards infections. In order to prevent major economic losses due to diseases, variousmedications are used for treatment and prevention of infections. The use of antimicrobialdrugs in aquacultures could lead to emergence of resistance in pathogenic microorganisms.Alternatives are being sought over the last few years to replace antibiotics, and medicinalplants are one of available options for this purpose. These plants are rich in secondarymetabolites and phytochemical compounds, which have an effect against viral, bacterial, andparasitic diseases in fish. Their main advantage is their natural origin and most of these plantsdo not represent threat for human health, the fish, and the environment. The goal of this reviewis to present information on the treatment of viral, bacterial, and parasitic diseases in fishthrough medicinal plants, with focus on the mechanisms of action of the identified secondarymetabolites, fractions, or plant extracts.
- Full Text:
- Date Issued: 2018
Cyclodextrin grafted calcium carbonate vaterite particles: efficient system for tailored release of hydrophobic anticancer or hormone drugs
- Lakkakula, Jaya R, Kurapati, Rajendra, Tynga, Ivan, Krause, Rui W M, Abrahamse, Heidi, Raichur, Ashok M
- Authors: Lakkakula, Jaya R , Kurapati, Rajendra , Tynga, Ivan , Krause, Rui W M , Abrahamse, Heidi , Raichur, Ashok M
- Date: 2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/125435 , vital:35783 , https://doi.org/10.1039/C6RA12951J
- Description: Porous CaCO3 microparticles have been used earlier for sustained drug release of hydrophilic drugs but have certain drawbacks for use with hydrophobic drugs. Hence, to overcome these drawbacks, a novel composite of CaCO3 along with cyclodextrin (CD–CaCO3) for the delivery of hydrophobic drugs was developed. Cyclodextrins (CDs), when incorporated within CaCO3, increased the porosity and surface area of microparticles thereby enhancing the encapsulation efficiency of hydrophobic drugs (5-Fluorouracil or Na-L-thyroxine) by forming inclusion complexes with cyclodextrin. Thermogravimetric and FTIR studies confirmed the interaction between the cyclodextrin and CaCO3 microparticles. Raman spectra confirmed the peak of vaterite crystals before and after loading of hydrophobic drugs within the composite. In vitro release studies when performed at pH 4.8 (5-Fu) and pH 1.2 (Na-L-thy) showed release at low pH as CaCO3 is soluble at acidic pH unlike slower release at basic pH. Release kinetics followed a Higuchi kinetic model at pH 4.8 (5-Fu) and pH 1.2 (Na-L-thy) respectively.
- Full Text:
- Date Issued: 2016
- Authors: Lakkakula, Jaya R , Kurapati, Rajendra , Tynga, Ivan , Krause, Rui W M , Abrahamse, Heidi , Raichur, Ashok M
- Date: 2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/125435 , vital:35783 , https://doi.org/10.1039/C6RA12951J
- Description: Porous CaCO3 microparticles have been used earlier for sustained drug release of hydrophilic drugs but have certain drawbacks for use with hydrophobic drugs. Hence, to overcome these drawbacks, a novel composite of CaCO3 along with cyclodextrin (CD–CaCO3) for the delivery of hydrophobic drugs was developed. Cyclodextrins (CDs), when incorporated within CaCO3, increased the porosity and surface area of microparticles thereby enhancing the encapsulation efficiency of hydrophobic drugs (5-Fluorouracil or Na-L-thyroxine) by forming inclusion complexes with cyclodextrin. Thermogravimetric and FTIR studies confirmed the interaction between the cyclodextrin and CaCO3 microparticles. Raman spectra confirmed the peak of vaterite crystals before and after loading of hydrophobic drugs within the composite. In vitro release studies when performed at pH 4.8 (5-Fu) and pH 1.2 (Na-L-thy) showed release at low pH as CaCO3 is soluble at acidic pH unlike slower release at basic pH. Release kinetics followed a Higuchi kinetic model at pH 4.8 (5-Fu) and pH 1.2 (Na-L-thy) respectively.
- Full Text:
- Date Issued: 2016
Facile deposition of gold nanoparticle thin films on semi-permeable cellulose substrate
- Sosibo, Ndabenhle, Mdluli, Phumlani, Mashazi, Philani N, Tshikhudo, Robert, Skepu, Amanda, Vilakazi, Sibulelo, Nyokong, Tebello
- Authors: Sosibo, Ndabenhle , Mdluli, Phumlani , Mashazi, Philani N , Tshikhudo, Robert , Skepu, Amanda , Vilakazi, Sibulelo , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/242638 , vital:51063 , xlink:href="https://doi.org/10.1016/j.matlet.2012.08.043"
- Description: This study reports the facile method for the deposition of gold nanoparticle thin film onto a monoporous semi-permeable cellulose membrane through the diffusion of borohydride ions leading to the reduction of AuCl4− ions. The synthesis of gold nanoparticle thin film was deposited on one side of the membrane that was exposed to AuCl4− ions while the other side containing a reducing agent remained clear. The gold nanoparticle thin film exhibited a broad surface plasmon resonance (SPR) peak at 529 nm. Various characterization techniques were employed and all demonstrated the presence of gold thin film. The reported method represents a simplistic method for the deposition of gold nanoparticle thin films and various other metal nanoparticles may be deposited following this method.
- Full Text:
- Date Issued: 2012
- Authors: Sosibo, Ndabenhle , Mdluli, Phumlani , Mashazi, Philani N , Tshikhudo, Robert , Skepu, Amanda , Vilakazi, Sibulelo , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/242638 , vital:51063 , xlink:href="https://doi.org/10.1016/j.matlet.2012.08.043"
- Description: This study reports the facile method for the deposition of gold nanoparticle thin film onto a monoporous semi-permeable cellulose membrane through the diffusion of borohydride ions leading to the reduction of AuCl4− ions. The synthesis of gold nanoparticle thin film was deposited on one side of the membrane that was exposed to AuCl4− ions while the other side containing a reducing agent remained clear. The gold nanoparticle thin film exhibited a broad surface plasmon resonance (SPR) peak at 529 nm. Various characterization techniques were employed and all demonstrated the presence of gold thin film. The reported method represents a simplistic method for the deposition of gold nanoparticle thin films and various other metal nanoparticles may be deposited following this method.
- Full Text:
- Date Issued: 2012
"Get organised": a practical student manual
- Authors: Western Cape Youth League
- Date: 1985-10
- Subjects: Youth -- Political activity -- Western Cape (South Africa) , Students -- Political activity -- Western Cape (South Africa) , Apartheid -- South Africa , Student government -- South Africa
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/76262 , vital:30528
- Description: The past few months have seen our courageous youth take to the streets to demonstrate their disgust against this system of exploitation and oppression. This militant fervour has touched many young hearts and minds. However, there is always the danger that these energies will burn out and dissipate. Demoralisation can so easily set in if these energies are not constructively channeled. "Channeled into what?” you may ask. ORGANISATIONS. It is only through strong organisations which attempt to give guidance and direction that meaningful action can be undertaken. The WCYL recognises the important need for students to begin to discuss broader issues such as The History of Struggle in S.A. or The Nature of S.A. Society. It is only when students begin to grapple with broader issues such as these, together with more specific ones, in a co-ordinated manner, will their actions be more effective. To this end has "GET ORGANISED" been designed. The handbook is intended as a guide for students in their efforts to organise SRC’s, awareness programmes, among other things, in schools.
- Full Text: false
- Date Issued: 1985-10
- Authors: Western Cape Youth League
- Date: 1985-10
- Subjects: Youth -- Political activity -- Western Cape (South Africa) , Students -- Political activity -- Western Cape (South Africa) , Apartheid -- South Africa , Student government -- South Africa
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/76262 , vital:30528
- Description: The past few months have seen our courageous youth take to the streets to demonstrate their disgust against this system of exploitation and oppression. This militant fervour has touched many young hearts and minds. However, there is always the danger that these energies will burn out and dissipate. Demoralisation can so easily set in if these energies are not constructively channeled. "Channeled into what?” you may ask. ORGANISATIONS. It is only through strong organisations which attempt to give guidance and direction that meaningful action can be undertaken. The WCYL recognises the important need for students to begin to discuss broader issues such as The History of Struggle in S.A. or The Nature of S.A. Society. It is only when students begin to grapple with broader issues such as these, together with more specific ones, in a co-ordinated manner, will their actions be more effective. To this end has "GET ORGANISED" been designed. The handbook is intended as a guide for students in their efforts to organise SRC’s, awareness programmes, among other things, in schools.
- Full Text: false
- Date Issued: 1985-10
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