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A biochemical study of the antidiabetic and anticogulant effects of Tulbaghia Violacea

  • Authors: Davison, Candice
  • Date: 2010
  • Subjects: Medicinal plants -- South Africa , Diabetes -- Alternative treatment -- South Africa , Violaceae -- Therapeutic use -- South Africa , Anticoagulants (Medicine) , Plants -- Analysis
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:10311 , http://hdl.handle.net/10948/1523 , Medicinal plants -- South Africa , Diabetes -- Alternative treatment -- South Africa , Violaceae -- Therapeutic use -- South Africa , Anticoagulants (Medicine) , Plants -- Analysis
  • Description: Secondary metabolites derived from plants, especially those used by traditional healers, are at the forefront of new drug development in combating diseases such as cancer and diabetes. Garlic is employed in indigenous medicine all over the world for the treatment of a variety of diseases. Dietary garlic has been recognized for its beneficial health effects. In particular, garlic consumption has been correlated with (i) reduction of risk factors for cardiovascular diseases and cancer, (ii) stimulation of immune function, (iii) enhanced detoxification of foreign compounds, (iv) hepatoprotection, (v) antimicrobial effects, (vi) antioxidant effects, and most importantly (vii) its hypoglycemic and anticoagulant properties. Due to these beneficial properties, garlic and its closely related genera which includes Tulbaghia violacea, may be useful as coadjuvant therapy in the treatment of type 2 diabetes and some of its physiological complications. The aim of this study was to determine if T. violacea has antidiabetic and anticoagulant properties. This was performed in vitro using both aqueous and organic extracts of the roots, leaves and bulbs. An organic extract was able to improve glucose-stimulated insulin secretion (GSIS) in INS-1 pancreatic β-cells and glucose uptake in Chang liver cells. The BO extract had no effect on the glucose uptake in 3T3-L1 an adipose cell line and reduced glucose utilisation in C2C12, a skeletal muscle cell line. Some of the properties displayed by T. violacea in this study are consistent with those found in similar studies with garlic extracts. It was observed that the BO extract increased the membrane potential and Glut-2 expression in INS-1 cells cultured at hyperglycemic levels, however, at normoglycemic levels a reduction was observed. The oxygen consumption increased at both glycemic levels due to treatment with the BO extract. Platelets were exposed to the extracts to determine their effects upon platelet aggregation, adhesion and protein secretion. Since the BO extract displayed the highest potential at inhibiting platelet aggregation and adhesion. A rat model was used in ex vivo studies to determine if the extract exhibited the same effect in a physiological model. It was noted that the BO extract exhibited a higher degree of inhibition on platelet aggregation and adhesion than the positive control, aspirin. The BO extract reduced clotting times in the prothrombin time (PT) test, but prolonged the clotting time in the actived partial thromboplastin time (APTT) assay in the ex vivo model; however, it had no affect on these clotting assays in the in vitro model using human blood. The BO extract increased the D-dimer and Fibrinogen-C levels in the in vitro model, but had no effect on the D-dimer concentrations and lowered the Fibrinogen-C levels in the ex vivo model. The active compounds in the extract remain to be elucidated.
  • Full Text:
  • Date Issued: 2010

A bioinorganic investigation of some metal complexes of the Schiff base, N,N'-bis(3-methoxysalicylaldimine)propan-2-ol

  • Authors: Mopp, Estelle
  • Date: 2010 , 2012-04-13
  • Subjects: Schiff bases , Bioinorganic chemistry , Metal complexes , Transition metal complexes , Transition metals , Cancer -- Chemotherapy , Ligands -- Toxicity , Antineoplastic agents
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:4413 , http://hdl.handle.net/10962/d1006768 , Schiff bases , Bioinorganic chemistry , Metal complexes , Transition metal complexes , Transition metals , Cancer -- Chemotherapy , Ligands -- Toxicity , Antineoplastic agents
  • Description: This thesis includes the synthesis, characterisation, antioxidant and antimicrobial activities of Cu(II)-, Co(II)- and Co(III) complexes with N,N'-bis(3- methoxysalicylaldimine)propan-2-ol, 2-OH-oVANPN. The Schiff base ligand, 2-OHoVANPN, is derived from o-vanillin and 1,3-diaminopropan-2-ol. The o-vanillin condensed with 1,3-diaminopropan-2-ol in a 2:1 molar ratio yields this potential tetraor pentadentate ligand. The complexes synthesized are tetra (or penta or hexa) coordinated. Formation of the complexes is symbolized as follows:- MX₂ + 2-OH-oVANPN (2:1) -> [M(2-OH-oVANPN)Xn] + HnX MX₂ + 2-OH-oVANPN (2:1) -> [Mn(2-OH-oVANPN)OH] + H₂X₂ MX₂ + (o-vanillin : diaminopropanol) (1:1) -> [M(1:1)X₂] MX₂ + (o-vanillin : diaminopropanol) (1:1) -> [M₃(1:1)X₄] M = Cu(II), Co(II) or Co(III); X = Cl; n = 1, 2. Their structural features have been deduced from their elemental analytical data, IR spectral data, and electronic spectral data. With the exception of {Cu₃(C₁₁H₁₄N₂O₃)(Cl)₄(H₂O)₆}(A4), the Cu(II) complexes were monomeric with 2-OH-oVANPN acting as a tetradentate ligand. A binuclear Co(II) complex, [Co₂(C₁₉H₁₉N₂O₅)(OH)] (B1), was synthesised and the rest of the Co(II) and Co(III) complexes were monomeric with chloride ions coordinating to the metal centre in some cases. Electronic data suggest that the cobalt(II) complexes have octahedral geometries and the copper(II) complexes have square planar structures – Co(III) is likely to be octahedral. Thermal analyses, which included the copper-block-method for determining sublimation temperatures, revealed that some copper(II) and cobalt(II) complexes are hygroscopic and sublime at 200 °C and below. DSC analyses of the Cu(II) complexes gave exotherms around 300 °C for complexes K[Cu(C₁₉H₂₀N₂O₅)(OH)]·2H₂O (A1) and [Cu(C₁₁H15N₂O₃)(Cl)₂]·2H₂O (A2) and above 400 °C for [Cu(C₁₁H₁₆N₂O₃)(Cl)₂] (A3) and {Cu₃(C₁₁H₁₄N₂O₃)(Cl)₄(H₂O)₆} (A4). Antioxidant studies were carried out against the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·). The cobalt(II) complex, [Co₂(C₁₉H₁₉N₂O₅)(OH)] (B1), which was synthesized in the presence of KOH, had no antioxidant activity, whilst the other cobalt(II) complexes, [Co(C₁₇H₁₇N₂O₅(Cl))]·1½H₂O (B2), [Co(C₁₉H₂₂N₂O₅) (Cl)₂]·5½H₂O (B3) and [Co(C₁₉H₂₂N₂O₅)(Cl)₂]·5½H₂O (B4), which were synthesised in the absence of KOH, demonstrated antioxidant activity. The latter complexes are candidates for cancer cell line testing, while [Cu(C₁₁H₁₆N₂O₃)(Cl)₂] (A3), {Cu₃(C₁₁H₁₄N₂O₃)(Cl)₄(H₂O)₆} (A4), [Co(C₁₉H₂₁N₂O₅)(Cl)₂ ]·5H₂O (C2) and [Co(C₁₉H₂₀N₂O₅)(Cl)]·3H₂O (C3) may show anticancer activity through possible hydrolysis products. Most of the complexes synthesized displayed antimicrobial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Aspergillus niger and Candida albicans. The results indicated that complexes [Cu(C₁₁H₁₆N₂O₃)(Cl)₂](A3), [Co(C₁₉H₂₂N₂O₅)(Cl)₂]·5½H₂O (B3) and [Co(C₁₉H₂₁N₂O₅)(Cl)₂ ]·5H₂O (C2) are active against the Gram-negative Ps. aeruginosa and that the ligand, 2-OH-oVANPN, did not have any activity. The same trend was observed with 2-OH-oVANPN, {Cu₃(C₁₁H₁₄N₂O₃)(Cl)4(H₂O)₆} (A4) and [Co(C₁₉H₂₀N₂O₅)(Cl)]·3H₂O (C3) against the Gram-positive S. aureus. As for activity against E. coli and C. albicans, some complexes showed more activity than the ligand. There is an observed trend here that the metal complexes are more active (toxic) than the corresponding ligand, which is in agreement with Tweedy’s chelation theory.
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  • Date Issued: 2010

A bioinorganic study of some cobalt(II) Schiff base complexes of variously substituted hydroxybenzaldimines

  • Authors: Shaibu, Rafiu Olarewaju
  • Date: 2008
  • Subjects: Cobalt Schiff bases Artemia Spectrum analysis Ligands -- Analysis Bioinorganic chemistry Antineoplastic agents Cancer -- Chemotherapy Ligands -- Toxicity
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:4394 , http://hdl.handle.net/10962/d1006009
  • Description: Syntheses of Schiff bases were carried out by reacting salicylaldyhde, ortho-vanillin, para-vanillin or vanillin with aniline, 1-aminonaphthalene, 4- and 3-aminopyridine, and also with 2- and 3-aminomethylpyridine. The various Schiff bases obtained from the condensation reaction were reacted with CoCl₂.6H₂0, triethylamine stripped CoCl₂.6H₂0 or Co(CH₃COO)₂ to form cobalt(Il) complexes of ratio 2:1. The complexes obtained from cobalt chloride designated as the "A series" are of the general formulae ML₂X₂.nH₂0 , (L = Schiff base, X = chlorine) while those obtained from cobalt acetate or triethylamine stripped cobalt chloride denoted as "B" and C" are of the general formulae ML₂. nH₂0. The few complexes that do not follow the general formulae highlighted above are: IA [M(HL)₃.Cl₂], (L = N-phenylsalicylaldimine), 4A = (MLCl₂), (L = N-phenylvanaldiminato), 7 A and 21 A (ML₂), (L = N-naphthyl-o-vanaldiminato, and N-methy-2-pyridylsalicylaldiminato respectively), 8A = MLCI, (L = N-naphthylvanaldiminato), 12A = M₂L₃Cl₂, (L = N-4-pyridylvanaldiminato), 15A (MLCI), (L = N-3-pyridyl-o-vanaldiminato). The ligands and their complexes were characterized using elemental analyses and cobalt analysis using ICP, FT-IR spectroscopy (mid and far-IR), NIR-UV/vis (diffuse reflectance), UV/vis in an aprotic and a protic solvents, while mass spectrometry, ¹HNMR and ¹³CNMR, was used to further characterized the ligands. The tautomeric nature of the Schiff bases were determined by examining the behaviour of Schiff bases and their complexes in a protic (e.g. MeOH) and non-protic (e.g. DMF) polar solvents. The effects of solvents on the electronic behaviour of the compounds were also examined. Using CDCl₃, the NMR technique was further used to confirm the structures of the Schiff bases. The tentative geometry of the complexes was determined using the spectra information obtained from the far infrared and the diffuse reflectance spectroscopy. With few exceptions, most of the "A" series are tetrahedral or distorted tetrahedral, while the "B + C" are octahedral or pseudooctahedral. A small number of complexes are assigned square-planar geometry owing to the characteristic spectral behaviour shown. In order to determine their biological activity, two biological assay methods (antimicrobial testing and brine shrimp lethality assay) were used. Using disc method, the bacteriostatic and fungicidal activities of the various Schiff bases and their respective complexes to Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa as well as Aspergillus niger, were measured and the average inhibition zones are tabulated and analysed. Both the Schiff bases and their complexes showed varying bacteriostatic and fungicidal activity against the bacteria and fungus tested. The inhibition activity is concentration dependent and potential antibiotic and fungicides are identified. To determine the toxicity of the ligands and their corresponding cobalt(II) complexes, brine shrimp lethality assay was used. The LD₅₀ of the tested compounds were calculated and the results obtained were tabulated for comparison.
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  • Date Issued: 2008

A bitcoin framework : an alternative payment system for marginalized areas of South Africa using low-end mobile phones

  • Authors: Dlamini, Nelisiwe Peaceness
  • Date: 2016
  • Subjects: Electronic funds transfers -- South Africa Bitcoin -- South Africa Mobile commerce -- South Africa
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: http://hdl.handle.net/10353/11884 , vital:39115
  • Description: The emergence of the cryptocurrency Bitcoin, has invoked the need for developing financial systems that can be used to transfer digital value. This would serve as a solution to developing countries especially the challenged ones, when it comes to accommodating the financial needs of the disadvantaged people. Moreover, it facilitates access to financial services to allow them to transact with ease. Numerous companies have taken advantage of the prevalence of mobile phones and introduced financial platforms to provide financial inclusion to disadvantaged people. Financial institutions and Mobile Network Operators (MNO) have developed platforms such as cell phone banking services, mobile money, mobile wallets, and electronic wallets that can be used to provide affordable financial services. Although this is the case, alternative platforms that are affordable and accessible through mobile phones are still required. Therefore, this study proposes a Bitcoin framework that can be used as an alternative platform through low-end mobile phones to provide access to financial services to the disadvantaged people in marginalized areas. To prove the concept of the proposed Bitcoin framework, a Mobile Bitcoin Wallet System (MBWS) prototype was developed, which allows a person using a low-end mobile phone with no intervening technology such as Internet or Bluetooth, to access a Bitcoin wallet by sending a Short Message Service (SMS). This enables Bitcoin to be accessed more easily and affordably by the people. Thus the developed prototype conceptualizes an alternative payment system or a payment method that can augment the existing payment methods. The MBWS is evaluated to assess if it can offer the services that other platforms offer by being compared to a cell-phone banking service. It was deployed on a computer connected to the Internet to enable a connection to the Bitcoin network and access to the blockchain which records all the transactions that take place in Bitcoin. Although this system provides access to the Bitcoin wallet, for it to be applied to areas where people require an alternative payment system, it still needs to be enhanced for such use. This includes scaling the system and adding more functions to it.
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  • Date Issued: 2016

A blended learning toolkit that accommodates multiple learning styles

  • Authors: Mills, Steven Christopher
  • Date: 2019
  • Subjects: Blended learning , Learning strategies Learning
  • Language: English
  • Type: Thesis , Masters , MCom
  • Identifier: http://hdl.handle.net/10948/30452 , vital:30945
  • Description: The purpose of this study was to identify how blended learning can be designed and incorporated to accommodate multiple learning styles within modules in the Department of Computing Sciences. A design theory was created through an analysis of literature and exploration into the backgrounds of students and lecturers within the Department of Computing Sciences. The design theory is: Blended learning can be a useful approach to accommodate multiple learning styles. Guidelines, and by extension a toolkit, facilitate the development of blended learning and provide effective tools to enable lecturers to successfully incorporate blended learning into their modules. Design-Based Research (DBR) was followed in this study, using a mixed-methods and iterative approach to determine the accuracy of the design theory. For the first iteration, the toolkit was implemented in two modules within the Department of Computing Sciences and for the second iteration, four modules. DBR produces a theoretical contribution and a practical artefact. The most important theoretical contributions are the design theory and guidelines for incorporating blended learning that accommodates multiple learning styles. The practical artefacts are the toolkit and tools therein. The toolkit, which was accessed via a website, guides lecturers through the process of incorporating blended learning that accommodates multiple learning styles and provides them with the necessary tools to do so. The design theory was proven in the evaluation that used a questionnaire to understand the lecturers’ experiences regarding the toolkit and the design theory. Therefore, the guidelines for applying blended learning is a useful approach to address multiple learning styles.
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  • Date Issued: 2019

A bone fragment

A book history study of Michael Radford's filmic production William Shakespeare's The Merchant of Venice

  • Authors: Green, Bryony Rose Humphries
  • Date: 2008
  • Subjects: Shakespeare, William, 1564-1616 -- Film adaptations Shakespeare, William, 1564-1616. Merchant of Venice Merchant of Venice (Motion picture: 2004) English drama -- Film and video adaptations Film adaptations -- History and criticism
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:2197 , http://hdl.handle.net/10962/d1002239
  • Description: Falling within the ambit of the Department of English Literature but with interdisciplinary scope and method, the research undertaken in this thesis examines Michael Radford’s 2004 film production William Shakespeare’s The Merchant of Venice using the Book History approach to textual study. Previously applied almost exclusively to the study of books, Book History examines the text in terms of both its medium and its content, bringing together bibliographical, literary and historical approaches to the study of books within one theoretical paradigm. My research extends this interdisciplinary approach into the filmic medium by using a modified version of Robert Darnton’s “communication circuit” to examine the process of transmission of this Shakespearean film adaptation from creation to reception. The research is not intended as a complete Book History study and even less as a comprehensive investigation of William Shakespeare’s The Merchant of Venice. Rather, it uses a Shakespearean case study to bring together the two previously discrete fields of Book History and filmic investigation. Drawing on film studies, literary concepts, cultural and media studies, modern management theory as well as reception theories and with the use of both quantitative and qualitative data, I show Book History to be an eminently useful and constructive approach to the study of film.
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  • Date Issued: 2008

A brain-compatible approach to the presentation of cyber security educational material

  • Authors: Reid, Rayne
  • Date: 2012
  • Subjects: Data protection -- Management , Computer security -- Management
  • Language: English
  • Type: Thesis , Masters , MTech
  • Identifier: vital:9819 , http://hdl.handle.net/10948/d1019895
  • Description: Information is an extremely important asset in modern society. It is used in most daily activities and transactions, and, thus, the importance of information is acknowledged by both organisational and private home information users. Unfortunately, as with any asset, there are often threats to this asset and, therefore, an information security solution is required to protect information against potential threats. Human beings play a major role in the implementation and governing of an entire information security process and, therefore, they have responsibilities in this regard. Thus, the effectiveness of any information security solutions in either an organisational or a private context is dependent on the human beings involved in the process. Accordingly, if these human beings are either unaware or not knowledgeable about their roles in the security solution they become the weak link in the information security solutions and, thus, it is essential that all these information users be educated in order to combat any threats to the information security. Many of the current information security education programmes and materials are not effective, possibly because the majority of these current approaches have been designed without using a sound pedagogical theory. In addition, many of these programmes also only target organisational users. This, in turn, is problematic as information security education is required by everybody, organisational and private information users alike. This dissertation addressed the lack of a pedagogical basis in the designing of information security educational courses suited to an extremely broad target audience. Accordingly, the dissertation set out to demonstrate how a pedagogy, which is broadly used and accepted for a diverse target audience of learners, could be applied to the design of the presentation of a web based, cyber security educational courses.
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  • Date Issued: 2012

A bring your own device information security behavioural model

  • Authors: Musarurwa, Alfred
  • Date: 2017
  • Subjects: Data protection Computer security -- Management Privacy, Right of
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: http://hdl.handle.net/10353/8587 , vital:33166
  • Description: The Bring Your Own Device (BYOD) phenomenon has become prevalent in the modern-day workplace, including the banking industry. Employees who own devices have become the unintended administrators of the organisation’s information as their mobile devices often carry information belonging to the organisation. The unintended administrator is not necessarily schooled or aware of the information security risks and challenges that are associated with the BYOD. This inadvertently shifts the management of organisational information security from the information technology (IT) administrator to the unintended administrator. This shift leaves the organisation at risk of information security breaches that can permeate the organisation, which result from the behaviour that the unintended administrator displays when operating the mobile device. This study introduces the BYOD Information Security Behavioural (BISB) model. The model constructs are a combination of individual and organisational traits of the unintended administrator. The purpose of this study is to mitigate the risks posed by the unintended administrator in organisations through the implementation this model. The risk that the unintended administrator poses in relation to the BYOD phenomenon results in chief information officers (CIOs) being unable to totally control these mobile devices. Traditional endpoint information security management tools and methods can no longer secure devices in the BYOD the way they can in the traditional network where they are confined to the organisation’s IT administrator. This results in the organisation’s information security becoming the responsibility of the unintended administrator. This study was conducted in the banking sector in Zimbabwe. It is noteworthy that the BYOD phenomenon has become prevalent in the banking sector among other organisational sectors like education, health or even government departments. Information security is also an important component of the banks as such and a choice was made to conduct the study in the banking industry. The design science research paradigm was followed in this study and included a survey of 270 bank employees in Zimbabwe, which received 170 complete responses. A literature review on both employee behaviour and organisational culture was conducted, followed by a case study of a commercial bank in Zimbabwe. The literature review culminated in traits that were then classified as individual traits and organisational traits. Six constructs –, knowledge, attitude, habit, environment, governance and training – were identified from the literature and combined to form the BYOD information security behavioural (BISB) model. Statistical calculations were conducted on the survey results which informed the reliability, validity and rigour of the model constructs. An expert review including industry experts was conducted to evaluate the BISB model. This study concludes by recommending that organisations in Zimbabwe should make use of the BISB model to mitigate the information security risks that are posed by the unintended administrator. While there are technical solutions for managing the information security risks that come with the BYOD, this study points out that without harnessing the individual and organisational traits that make up the BYOD information security behavioural model for the unintended administrator, technical solutions alone will not be effective.
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  • Date Issued: 2017

A budget and expenditure review of public hospital facilities in the Eastern Cape in transition towards National Health Insurance

  • Authors: Ndlovu, Garfield OG
  • Date: 2018
  • Subjects: Health services administration--South Africa--Eastern Cape Government spending policy--South Africa--Eastern Cape Health services administration
  • Language: English
  • Type: Thesis , Masters , Public Health Leadership
  • Identifier: http://hdl.handle.net/10353/11139 , vital:37174
  • Description: The quest to ameliorate and enhance the equitable allocation of resources in the Health Industry remains a global challenge, in particular the distribution of funding resources in public sector health facilities. The need to analyse and understand the appropriation of budget and utilisation of funds by hospital facilities is important in the in the Eastern Cape. The focus of the study seeks to explore recommendations that can be employed in the provincial budgeting process of Hospital Facilities, in a bid to optimise efficiency and improve the funding process as part of the provincial readiness activities towards the realisation of the NHI System and funding approach, wherein the NHI Fund will be a public entity that is not in business to make profit (NHI Booklet 2012: 05). This fund will introduce new systems of paying hospitals and professionals for the services they provide, aiming to be fair to them but to put a stop to unreasonable profits (NHI Booklet 2012: 05). The research has employed the use of descriptive quantitative techniques in order to undertake an expenditure review of existing financial data with respect to the Eastern Cape public Hospitals. The study followed a quantitative descriptive research design, the purpose of this study is that, quantitative research deals in numbers, logic, and an objective stance (Babbie: 2010). The Quantitative aspect of the study found that the data provided, allowed the researcher to organise, synthesise, prioritise and assign value to specific key performance indicators that would be used for the appraisal of hospital facilities in relation to the expenditure patterns based which would present a glimpse into how the Eastern Cape department of health utilises funding resources.
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  • Date Issued: 2018

A bulk and fraction-specific geochemical study of the origin of diverse high-grade hematitic iron ores from the Transvaal Supergroup, Northern Cape Province, South Africa

  • Authors: Moloto, William
  • Date: 2017
  • Subjects: Iron ore -- South Africa -- Transvaal Supergroup , Hematite -- South Africa -- Transvaal Supergroup , Transvaal Supergroup (South Africa)
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: http://hdl.handle.net/10962/50546 , vital:25998
  • Description: The Paleoproterozoic Transvaal Supergroup in the Northern Cape Province of South Africa is host to high-grade, Banded Iron Formation-hosted hematite iron-ore deposits and is the country’s most important source of iron to date. Previous studies suggest the origin of these iron ores to be ancient supergene, and that the ore forming process would have therefore pre-dated deposition of the basal Mapedi shales of the Olifansthoek Supergroup that unconformably overlies the Transvaal strata. The nature of the protolith to the ores has been suggested to be largely BIF of the Asbestos Hills Subgroup, and mainly the Kuruman BIF. The work presented in this thesis seeks to provide insights into the diversity of processes that are likely to have been involved during the genesis of these high-grade iron ores, in the context of constraining the pre-ore lithologies and the relative role of supergene-style, largely residual enrichment processes versus any possible metasomatic hydrothermal effects. This study had as primary focus the application of combined bulk and fraction-specific geochemical applications on representative iron-ore samples from four different localities in the Northern Cape Province, namely King/Khumani, Beeshoek, Heuninkranz and Hotazel. The collected samples show a variety of textures and also capture different pre-unconformity stratigraphic sections of BIF. The key objective was to assess whether the fraction-specific analytical results could provide any firm constraints for the origin of the ferrous and non-ferrous matrix fractions of the ores, namely whether they represent any combinations of protolith residue, allochtonously-introduced detritus or hydrothermally-derived material, and whether the results are comparable and consistent across all samples studied. In particular, constraints were sought as to whether the ore protolith was exclusively BIF or may potentially have contained at least a fraction of other lithologic types, such as shale; and whether there is sufficient evidence to support solely a supergene model for the ores or the data suggest other more epigenetic models of ore formation involving the action of hydrothermal fluids Bulk-rock geochemical analyses reveal the overwhelming dominance of Fe-oxide (as hematite) in all samples, at concentrations as high as 99 wt.% Fe2O3. Major and trace-element abundances of all samples were re-calculated assuming only iron addition from the postulated protolith (average BIF and shale), and the results revealed atypical enrichments in the iron ores by comparison to average BIF, and more shale-like relative abundances when normalised against the Post-Archaean Average Shale (PAAS). Specifically, BIF-normalised diagrams show relative enrichments by as much as 53-95% for Al2O3; 11-86% for TiO2; and 4-60% for P2O5. By contrast, PAAS-normalised values display enrichments of 1-3% for Al2O3, 0.2-3% for TiO2, and 3-13% for P2O5. Similar observations can be made for the greatest majority of trace elements when normalised against average BIF as compared to normalisation against PAAS. A suite of trace element that include alkali earths (e.g. Ba, Sr) and transition metals (e.g. Ni, Zn) show enrichments that are unrelated to the apparently detrital siliciclastic fraction of the ores, and are therefore linked to a possible hydrothermal input. Fraction-specific extractions were performed via the adaptation of existing dissolution protocols using oxalic acid (iron-oxide fraction) followed by HF digestion (silicate-fraction). The analyses of the produced aliquots using ICP-MS techniques, focused mainly on the REE abundances of the separated ferrous and non-ferrous matrix fractions and their comparisons to bulk-rock REE signatures. The results lend further support to the suggestion that the ore samples contain a predominant shale-like signal which does not directly compare to published REE signatures for supergene or hydrothermal BIF-hosted iron-ore deposits alike. The data therefore collectively point to a post-unconformity epigenetic hydrothermal event/s of iron ore-formation that would have exploited not only BIF but also shale as suitable pre-ore protolith.
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  • Date Issued: 2017

A business intelligence framework for supporting strategic sustainability information management in higher education

  • Authors: Haupt, Ross
  • Date: 2016
  • Subjects: Business intelligence , Strategic planning -- Management
  • Language: English
  • Type: Thesis , Masters , MCom
  • Identifier: http://hdl.handle.net/10948/5319 , vital:20832
  • Description: In the higher education sector, a number of Higher Education Institutions (HEIs) are playing a leading role in promoting sustainable initiatives. Effectively managing these initiatives however can be a complex task and requires data and information from multiple aspects of operations. In an HEI, operating sustainably means ensuring financial sustainability, social sustainability, environmental sustainability and educational sustainability. In order to manage sustainability effectively, HEIs require an integrated tool that can provide information on all areas of sustainability. HEIs face a number of challenges in effectively managing sustainability information, such as siloed data and information, and poor sharing and communication of information. Business Intelligence (BI) can assist in overcoming many of the challenges faced by organisations in effectively managing strategic sustainability information. This study investigates both the constraints to effective sustainability information management and the challenges of BI. A BI framework to support effective strategic sustainability information management is proposed. Nelson Mandela Metropolitan University (NMMU) is one such HEI, which is affected by the challenges of managing strategic sustainability information. NMMU is therefore used as a case study in this research. A BI solution, Sustainable BI, was developed based on the proposed framework. The main goal of sustainable BI is to provide strategic management at NMMU with a tool that can provide integrated sustainability information that can assist in overcoming the challenges in effectively managing strategic sustainability information. Sustainable BI was evaluated by strategic management at NMMU who are responsible for managing sustainability at NMMU. The evaluation took place through a usability study. The study revealed to what extent Sustainable BI could effectively manage strategic sustainability information at NMMU. The BI framework was iteratively improved on based on the results of the evaluations. The contributions from this study are a model for sustainability management, a BI Framework to support strategic sustainability information management and a BI solution, Sustainable BI.
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  • Date Issued: 2016

A business model for medical subspecialty training in South Africa

  • Authors: Dalmeyer, Johannes Paulus Franciscus
  • Date: 2015
  • Subjects: Health care teams -- Training of -- South Africa , Medical care -- Needs assessment -- South Africa , Evidence-based medicine -- South Africa
  • Language: English
  • Type: Thesis , Doctoral , DPhil
  • Identifier: http://hdl.handle.net/10948/3508 , vital:20437
  • Description: The shortage of healthcare workers and doctors in the developing world compared to the developed world is a problem, and will continue to be so, due to the continual migration of qualified professionals and the inability of the state to remedy these shortfalls. A shortage of healthcare workers and specialist doctors will seriously hamper the Government’s National Health Insurance (NHI) plan, as well as the sustainability of the private health care sector. In addition, the duration of medical training in South Africa is exceptionally long. The three major hospital groups and other private corporates have over the last number of years taken limited initiative to fund education projects in conjunction with the academic institutions. However, these projects have been poorly focused and have been managed in an unstructured and detached manner. There is a desire from the private sector to get involved in these projects on a much larger scale through more formalised structures. Given this background, the primary objective of this research is to develop a business model for medical subspecialty training to complement the current academic subspecialty training in South Africa. A trial model for training subspecialists in reproductive medicine was developed as a first attempt to address the threatening shortages and training duration. This trial programme is the basis of this research. A two-phased process was used in collecting data. In Phase 1 data was collected from stakeholder groups. The results of this survey assisted in generating variables to include in the measuring instrument for the survey in Phase 2. In Phase 2 the perceptions and expectations of sub-specialists (reproductive subspecialists and cardiologists) regarding sub-specialty training was collected. The results of the demographic variables confirm the aging profile of subspecialist and the need to ensure succession. The results further showed that cardiologists and reproductive subspecialist expectations of the training of subspecialists are very similar except for their expectations on the training duration. Reproductive subspecialist respondents agreed more than cardiology subspecialist respondents that the training duration is too long. The biggest gap between perceptions and expectations is also with the factor training. The results showed that the expectations of subspecialists are not met for training. From these results a business model for the training of medical subspecialists is proposed. This proposed business model can play a complementary role to the existing state controlled system and form the bases of Public Private Partnerships (PPP) in medical training. This proposed business model will fit a developing country were the focus is on primary healthcare, with financial and capacity constraints. The proposed model would require role players to bring about change to accommodate a larger scale Public Private Partnership (PPP) to ensure the implementation of the model. The proposed decentralised business model for training subspecialists would allow the trainee subspecialist to practise as a specialist thus maintaining an acceptable income, and enable an expedited completion and lead to a wider dissemination of medical expertise that can be delivered in a wider national foot print. It further will provide for a structured Public Private Partnership.
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  • Date Issued: 2015

A business model for SMME's in the telecommunications sector in the Border Region

  • Authors: Oberholzer, Stephanus Marius
  • Date: 2007
  • Subjects: Business planning -- South Africa -- Eastern Cape , Telecommunication -- Planning -- South Africa -- Eastern Cape , Business enterprises -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: vital:8736 , http://hdl.handle.net/10948/795 , Business planning -- South Africa -- Eastern Cape , Telecommunication -- Planning -- South Africa -- Eastern Cape , Business enterprises -- South Africa -- Eastern Cape
  • Description: The telecommunications landscape in South Africa is changing. The monopolistic nature of the sector, previously dominated by Telkom has come to an end. Telecommunications companies, in particular SMMEs face the opportunity as well as challenges to find new ways of doing business successfully in this changing landscape. The research problem states a business model for SMMEs in the telecommunications sector. The author’s research is aimed to assist SMMEs in this sector to reposition them and be successful. The literature review focused on the local telecommunications market in South Africa, a comparisons between telecommunications markets in relation to other countries with similarities in their telecoms sectors as well as the opportunities and challenges SMMEs face in the market space. Regulation and new technologies pose opportunities but also potential dangers for business owners to conduct business. Traditionally, a typical resell model would be fully dependant on the way the monopolist determined the shape and structures of small companies, but the research indicated innovation and creativity will be the drivers to be successful today. The research design was done by using a survey questionnaire to telecoms end users. The literature review and a survey aimed at the consumer market were done and the findings highlights focus areas where SMMEs need to direct their energy and resources in to establish the business model. With reference to both the literature review and the empirical findings, the business model can be formulated and supported by a strong entrepreneurial person or group of people. In addition, the recommended business-level strategy is an integrated and coordinated set of commitments and actions the SMMEs will use to gain a competitive advantage by exploiting core competencies in specific telecoms markets.
  • Full Text:
  • Date Issued: 2007

A business plan for an international squid business

  • Authors: Botha, Gerald
  • Date: 2009
  • Subjects: Business planning -- South Africa Strategic planning -- South Africa , Seafood industry -- South Africa
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: http://hdl.handle.net/10948/21604 , vital:29716
  • Description: Talhado Fishing Enterprises (Pty) Ltd is a squid fishing company founded in 1988, with sea and land based freezing facilities. Operating from the East coast situated in the Port Elizabeth harbour, the company processes and packages its caught and bought out product for sales to its export customers situated in Spain and Italy. The company is privately owned, 38.8 percent owned by previously disadvantaged persons. This study examines the whether it would be feasible to expand its operations into the USA, namely into the California area where a squid fishery exists. The study further centres around the company’s existing markets, namely Spain and Italy, to establish whether demand exists to purchase this Californian squid specie. The reason for the study is that due to legislative and political issues growth in the squid industry in South Africa is limited. It is therefore considered pertinent to source further supply of product in order to expand its business. The aim of the study is establish whether it is feasible to expand the company’s operations internationally and does the outcome of this initial study warrant the development of an in depth business plan. In order to achieve these objectives the following approach was followed: A comprehensive literature study was conducted with regard to the industry internationally and locally; Interviews was conducted with independent experts such as attorneys and industry role players situated in California; Potential sellers of businesses were sourced in the California and interviews were arranged with these role players; The response to the interviews was measured against the literature study conducted and financial statements supplied.
  • Full Text:
  • Date Issued: 2009

A business process management framework for enhancing enterprise resource planning value derived in supply chain optimization

  • Authors: Sahdeo, Viresh
  • Date: 2018
  • Subjects: Reengineering (Management) , Workflow -- Management Performance -- Management Strategic planning
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: http://hdl.handle.net/10948/34833 , vital:33459
  • Description: Enterprise Resource Planning (ERP) systems easily diffuse knowledge and allow good business decisions for Information System (IS) technological and organizational advancement. This research is an investigation of how to improve the strategic management and operational efficiency of Enterprise Information Systems (EIS). A Business Process Management (BPM) framework was designed to integrate varying perspectives of organizational activities for wider collaboration and value derivation. The systematic methodology of Business process management (BPM) enables corporates to be more effective and efficient through continual process improvement. Elements used to build the BPM framework explain how to successfully derive value, inclusive of the performance indicators to measure outcomes. The model was tested with questionnaire data collected from corporates operating in the Southern African region and further refined based on Cronbach alpha reliability tests. The findings improve the interpretation of the determinants for the success of BPM and ERP IS from the user’s perspective. The results show that continuous improvement efforts and organisational support have positive influence on performance and validate the importance of quality, service, information, integration and workflow dependencies. Originality/value – This research extends prior work of BPM frameworks to follow up on customer orientation and servitization. Studies have not investigated relationship commitment between IT and operational business units. The relationship and interdependence of organisational functions is essential for Supply Chain value creation. Industrialization and information technology(IT) integration faces new opportunities. The agility of IT is further explored more into efforts of collaboration, structure, and innovation for future changes, emerging technologies and practices envisioned. This research seeks to propose a framework for the future development of smart supply chain, which can provide theory and case for intelligent operational activities with key technologies, such as RFID, Neural Networks, machine learning and artificial intelligence(AI).
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  • Date Issued: 2018

A business process model for blockchain-based South African real estate transactions

  • Authors: Tilbury, Jack Laurie
  • Date: 2020
  • Subjects: Blockchains (Databases) , Conveyancing -- Technological innovations , Real estate business -- Data processing , Real estate business -- South Africa -- Technological innovations
  • Language: English
  • Type: text , Thesis , Masters , MCom
  • Identifier: http://hdl.handle.net/10962/148380 , vital:38734
  • Description: The real estate transaction process has been described as inefficient and technologically outdated due to numerous stakeholders and predominantly paper-based operations. Despite the apparent bottlenecks in the current process, the implementation of new technology into the real estate sector has lagged. Several attempts have been made to modernise and digitise the business process but committed integration of assisting technology has lacked attention. This study examined the applicability and potential integration of blockchain technology into the business process of South African real estate transactions. Blockchain’s novelty means that research in this space, especially within South Africa, is limited. Of the research that has been conducted, no models of the business processes for South African or blockchain-based real estate transactions have been constructed. This study provides two business process models, illustrating the two different processes. The main contribution of this paper was an integrated business process model, illustrating how the various processes and stakeholder interactions for South African blockchain-based real estate transactions are conducted on one transaction platform, common to all participating stakeholders. This platform was named the South African Blockchain Land Exchange System (SABLES), which manages and facilitates these transactions in their entirety from start to finish. This model depicts an enhanced business process that provides increased security, transparency, and speed. These benefits will be realised by those who register, adopt, and transact on the platform. Through in-depth interviews, the integrated business process model was assessed. The findings produced a final and combined thematic map, representing the main themes of the analysed interview data, namely blockchain implementation strategies, business process applicability, information technology assimilation, current transaction context, and PropTech 3.0 success factors. The discussion revealed that the current transaction process lacks technological innovation, which increases pressure on the conveyancing role. It was also revealed that there is not only a need within the industry, but a desire, for newer technologies to assist the transaction process. In order to streamline and improve efficiency, business processes should leverage digital records and data, and strive for a solution beyond digitisation, achieving digitalisation. Digitalisation recognises digital documents as official and legal documents as opposed to simply being digital back-ups. This, coupled with the business process models, represent theoretical contributions.
  • Full Text:
  • Date Issued: 2020

A case for contemporary third literature: the black experience in the postmillennial fiction of three Kwela authors

  • Authors: Mthembu, Lumumba
  • Date: 2016
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: http://hdl.handle.net/10962/3322 , vital:20480
  • Description: This study seeks to uncover the manner in which the young black experience is constructed in three novels by Sifiso Mzobe, Kgebetli Moele and K. Sello Duiker. Young Blood, Untitled and Thirteen Cents all feature teenage narrators navigating the social milieu of South Africa in the twenty-first century. My analysis is informed by Frantz Fanon’s postcolonial theory because South Africa’s socio-economic landscape conforms to the divisions laid out in The Wretched of the Earth. I contend that post-apartheid South Africa is developing in a manner that is symptomatic of the Fanonian post-independence African state. My close reading of the novels teases out the conditions under which young black subjects must survive and express themselves. I look into the roles of the community, the government, the family, and the school in shaping this experience. Naturally, my discussion segues into questions of sexuality and gender as they intersect with race. I demonstrate how these texts fail and succeed as works of Third Literature, a genre derived from Third Cinema, which I have adapted due to its Fanonian ideological underpinning. Third Literature is a fundamentally revolutionary and activistic genre which seeks to pave the way for social change. In this regard, I concern myself with the recommendations these three authors may have for the readers of their texts. In conclusion, these texts demonstrate that racialized identities are social constructs with measurable experiential effects. However, there are ways of actively resisting or even
  • Full Text:
  • Date Issued: 2016

A case for geography in South African senior primary schools: an analysis and evaluation of current geographical thinking and practice

  • Authors: Taylor, Simon Michael
  • Date: 1995
  • Subjects: Geography -- Study and teaching (Elementary) -- South Africa -- Evaluation Geography teachers -- South Africa -- Attitudes Geography -- Study and teaching (Elementary) -- Curricula -- Comparative studies
  • Language: English
  • Type: Thesis , Masters , MEd
  • Identifier: vital:1428 , http://hdl.handle.net/10962/d1003309
  • Description: Geography faces several challenges in a changing South Africa. These include the challenge to initiate a primary curriculum that helps to provide a foundation for sustainable living in a society that faces serious problems of unemployment, violence, irreparable damage to the environment and the lack of housing, water and basic services for the majority of the population. This thesis attempts to provide a case for geography in the primary school by examining the value of the subject for pupils' development and by reviewing the strengths and weaknesses of an integrated approach in view of the possible introduction of an integrated primary curriculum in South Africa. The second aspect of the study is concerned with a survey of teachers in the Natal Education Department to evaluate the perceived value of geography as a subject and support for geography as a discrete subject. The main thrust of geography in the primary school is to develop concepts, skills, values and attitudes that allow pupils to be more understanding and caring about the local and global environment, about people, communities, species and the natural environment on which we all depend. The results of the survey reveal that teachers support geography as a discrete subject with an intra-curriculum approach. The introduction of an integrated core curriculum in South Africa would prove problematic as teachers are not in favour of an integrated approach across the curriculum. The lack of teacher support in Kenya for an integrated curriculum was one of the main reasons for its failure. Hopefully South Africa will learn from other countries experiences with introducing an integrated curriculum. Teachers value the role of geography in the education of the child and suggest the introduction of environmental and development themes to make the subject more relevant to children's lives. The syllabus analysis revealed that a unified pnmary curriculum is required which is influenced by the needs of society in South Africa. Recommendations are made regarding ideas for a future primary curriculum.
  • Full Text:
  • Date Issued: 1995

A case for institutional investigations in economic research methods with reference to South Africa's agricultural sector

  • Authors: Mbatha, Cyril
  • Date: 2008
  • Subjects: Economic development -- South Africa Economic development -- Research -- Methodology Agriculture -- South Africa Agriculture -- Economic aspects -- South Africa Agricultural productivity -- South Africa Agriculture -- Research -- South Africa South Africa -- Economic conditions
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:972 , http://hdl.handle.net/10962/d1002706
  • Description: Economic development remains elusive for many world economies, but especially those of African countries. The current global inequalities in terms of GNP per capita and human living standards between developed and developing nations have ensured that the challenges of food insecurities are only some of the many negative experiences of underdevelopment in the African continent. Hence, delivery pressures are increasing on policy makers and researchers to provide tangible and timely economic solutions to the resilient state of underdevelopment. In the policy fights against the challenges posed by a lack of development in South Africa, the agricultural sector has in the past and continues in the present to play a central role. Such is the case because the majority of citizens rely on agricultural production activities for their livelihoods. For instance, even though the sector only contributed four percent towards the national Gross Domestic Product in 2006, in the Eastern Cape Province, more than seventy percent of the total population resided in rural areas. Moreover, in 2004 more than sixty percent of the national formal and informal employment levels were found in the sector. These economic indicators do not only reinforce the assertions that high levels of geographical and sectoral inequalities exist in the country’s economy, but they also illustrate the importance of the agricultural sector in public policy attempts, which are aimed at achieving food security alongside long-term developmental objectives. Some economists, especially the proponents of institutionalism, have argued that most of the recommendations to public policy interventions from mainstream economic research endeavours are not adequately helpful. The recommendations generally lack well considered and socially effective ideas, mainly because there remains some level of ignorance about the impacts that institutions have on economic and social systems. Some argue that this ignorance is reflected in (flawed) hedonistic and rationalist assumptions made about economic actors and in the methodological thinking of many research designs and economic analyses. The misuse of formal tools and statistical methods, for example, are some of the important factors, which have led to failures of the discipline of economics to provide effective policy solutions to problems of underdevelopment and poverty, especially in poor country environments. The thesis, having taken account of the majority of criticisms levelled against the classical and new-classical economic schools of thought, argues that the discipline as a whole lacks a paradigmatic integration of institutional and new-classical economic perspectives to offer appropriate guidelines for a methodology aimed at achieving socially responsive research outputs. The lack of this integration has resulted in a skewed selection of methods by economists, which are employed in research without a supportive and in-depth understanding of institutional and social factors. To support the thesis, a more effective and integrated framework for economic research is developed and presented with case study illustrations in a cumulative manner. The 20th century history of agricultural policies in South Africa, the agricultural and institutional case studies from the Eastern Cape Province alongside reviews of other agricultural studies are all used in presenting a case for rigorous institutional investigations in general economic research. These are also used in developing the proposed integrated framework, which aims to give guidance in developing research methods, which are more socially responsive. Having shown the usefulness of the proposed research framework, the thesis recommends that public policy interventions (at national and local levels) should aim to eliminate all types of institutions which have high associated transactional costs. The interventions should also encourage the emergence and growth of the types of institutions, which present the lowest costs to initiatives of economic development. In the primary case studies from the Eastern Cape Province, the insecurity of land tenure and the various local initiatives of business ventures are highlighted as two examples of the types of institutions, which respectively present high and low transactional costs to local initiatives of agricultural and economic development.
  • Full Text:
  • Date Issued: 2008
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