A new synthetic approach for preparation of Efavirenz
- Authors: Chada, Sravanthi
- Date: 2017
- Subjects: Antiretroviral agents , Asymmetric synthesis , Enzyme inhibitors , HIV (Viruses) -- Enzymes
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/15512 , vital:28265
- Description: Efavirenz, a drug that is still inaccessible to millions of people worldwide, is potent non nucleoside reverse transcriptase inhibitor (NNRTI), is one of the preferred agents used in combination therapy for first-line treatment of the human immunodeficiency virus (HIV). NNRTIs attach to and block an HIV enzyme called reverse transcriptase, by blocking reverse transcriptase; NNRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body. Efavirenz can't cure HIV/AIDS, but taken in combination with other HIV medicines (called an HIV regimen) every day helps people with HIV live longer healthier lives. Efavirenz also reduces the risk of HIV transmission and can be used by children who are suffering from HIV/AIDS. All the above therapeutic uses of efavirenz prompted us to identify the novel and hopefully cost efficient synthetic methodology for the preparation of efavirenz. In this thesis a new synthetic method for asymmetric synthesis of efavirenz is described. This route started from commercially available starting materials and it is first established in traditional batch chemistry and further the parameters transferred to a semi continuous flow protocol for optimization.
- Full Text:
- Date Issued: 2017
A novel Arf GTPase assay for antimalarial drug discovery
- Authors: Swart, Tarryn
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/178558 , vital:42950
- Description: Access restricted until April 2022. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-04
A novel, improved throughput bioassay for determining the delative speed of antimalarial drug action using fluorescent vitality probes
- Authors: Laming, Dustin
- Date: 2020
- Subjects: Plasmodium falciparum , Malaria -- Treatment -- Africa , Antimalarials , Malaria vaccine
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/139902 , vital:37810
- Description: Malaria is one of the most prevalent diseases in Africa and Plasmodium falciparum is widely accepted as the most virulent of the malaria parasite species, with a fatality rate of 15 – 20 % of reported cases of infection. While various treatments have been accepted into early stage clinical trials, there has been little progress towards a proven vaccine. Pending a long-term solution, endemic countries rely heavily on the development of innovative drugs that are not only efficacious but are also quick acting. Traditional methods of evaluating antimalarial killing speeds via morphological assessments are inherently flawed by tedious, subjective interpretations of the heterogenous parasite morphology encountered in routine parasite culture conditions. This has led to the introduction of alternative assay formats to determine how rapidly compounds act on parasites in vitro: a parasite reduction ratio (PRR) assay that measures the recovery of parasite cultures from drug exposure; determining the shift in IC50 values of compounds when dose-response assays are carried out for different time periods; a bioluminescence relative rate of kill (BRRoK) assay that compares the extent to which compounds reduce firefly luciferase activity in transgenic parasites. Recent whole cell in vitro screening efforts have resulted in the generation of chemically diverse compound libraries such as the Medicines for Malaria Venture’s Pathogen Box, which houses 125 novel compounds with in vitro antiplasmodial activity. Assessing the relative killing speeds of these compounds would aid prioritizing fast-acting compounds that can be exploited as starting points for further development. This study aimed to develop a bioassay using the calcein-acetoxymethyl and propidium iodide fluorescent vitality probes, which would allow the relative speed of drug action on Plasmodium falciparum malaria parasites to be assessed and ranked in relation to each other using a quantitative, improved throughput approach. Initially applied to human (HeLa) cells, the assay was used to compare the relative speeds of action of 3 potential anti-cancer compounds by fluorescence microscopy. Subsequently adapted to P. falciparum, the assay was able to rank the relative speeds of action of standard antimalarials by fluorescence microscopy and two flow cytometry formats. Application of a multiwell flow cytometer increased throughput and enabled the assessment of experimental compounds, which included a set of artemisinin analogs and 125 antimalarial compounds in the MMV Pathogen Box. The latter culminated in the identification of five rapidly parasiticidal compounds in relation to the other compounds in the library, which may act as benchmark references for future studies and form the basis of the next generation of fast acting antimalarials that could be used to combat modern, resistant malaria.
- Full Text:
- Date Issued: 2020
A pastoral theological examination of inner healing
- Authors: Velthuysen, Daniel Nicholas
- Date: 1990
- Subjects: Pastoral theology , Healing -- Religious aspects -- Christianity , Mental healing -- Religious aspects -- Christianity , Inner child -- Religious aspects -- Christianity , Primal therapy -- Religious aspects -- Christianity
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1300 , http://hdl.handle.net/10962/d1016248
- Description: Doing a survey of the ministry of inner healing, one is arrested by three salient features: its pragmatic and correlative development, its lay orientation, and the inconsistent and naïve theoretical explanation of the phenomenon. Inner healing, or as it was first known, the healing of the memories, appears to have its roots with Agnes Sanford during the 1940's (Sandford 1982: 3-4). Over a period of time and through a series of events, Sanford experienced what she termed a healing of memories. After some reflection on her experiences she began to teach her views at the School of Pastoral Care started by her husband in 1958, at Camps Farthest Out (CFO), and at numerous churches and conferences.
- Full Text:
- Date Issued: 1990
A personality-based surveillance model for Facebook apps
- Authors: Van der Schyff, Karl Izak
- Date: 2020
- Subjects: Facebook (Electronic resource) , Electronic surveillance -- Psychological aspects , Online social networks -- Psychological aspects , Social media -- Psychological aspects , Personality
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/145534 , vital:38447
- Description: The surveillance of data through the use of Facebook Apps is an ongoing and persistent problem that impacts millions of users. Nonetheless, limited research has been conducted investigating to what extent a Facebook user’s personality influences their awareness of such surveillance practices. Thus, to understand this situation better, the current study inductively developed four propositions from secondary data sources as part of a detailed content analysis. Spanning three search and analysis phases the content analysis led to the development of the research model. Guided by the propositions and research questions, a questionnaire was developed based on the relevant constructs prescribed by the Theory of Planned Behaviour. This questionnaire was used, and a total of 651 responses were collected from Facebook users over the age of 18 years old and residing in the United States of America. Primary data took place at both a univariate and multivariate level with a specific focus on the development of a structural model. Interpretation of the structural model revealed that out of all the Big Five personality traits, Conscientiousness exhibited the strongest relationship with information security awareness followed by Openness to Experience and Neuroticism, respectively. The results further indicated that the model constructs based on attitude, social norms and awareness significantly influenced the intended use of Facebook Apps. The study also contributes by indicating which personality traits are most vulnerable to Facebook App surveillance. For example, it was found that individuals high in Conscientiousness are the least vulnerable with individuals high in Extraversion being the most vulnerable. Since the results indicate that not all the personality traits are significantly related to the model constructs, additional factors may contribute to App surveillance in this context. Concerning this, factors such as user apathy, information privacy, privacy concerns, control and Facebook dependency are discussed as a means to argue why this might be the case.
- Full Text:
- Date Issued: 2020
A petrological and mineralogical study of peridotite and eclogite xenoliths from certain kimberlite pipes
- Authors: Whitfield, Gavin
- Date: 1972
- Subjects: Petrology Peridotite Mineralogy Kimberlite Igneous rocks -- Inclusions Eclogite
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5044 , http://hdl.handle.net/10962/d1007690
- Description: Kimberlite, an ultrabasic diamond-bearing hypabyssal rock-type which has its origin in the Earth's upper mantle, characteristically contains rare, well-rounded xenoliths of peridotite and eclogite. These xenoliths, which undoubtedly originate from some considerable depth below the Earth's surface, possibly represent samples of upper mantle material. They have received much attention from earth scientists and numerous theories as to their origin have been proposed. Forty-two selected peridotite xenoliths from the Bultfontein, Wesselton, Dutoitspan and Roberts Victor kimberlite pipes of the Kimberley area, South Africa, and 24 eclogite xenoliths from the Roberts Victor pipe have been examined in detail using a variety of petrological and mineralogical techniques. The petrologic research comprises conventional petrographic studies, the determination of accurate modal compositions and the presentation of 22 new whole-rock chemical analyses, nine of which are of garnet peridotite, four of spinel peridotite and nine of eclogite, one being a diamondiferous specimen. Detailed mineralogical studies of the constituent minerals of the xenoliths comprises descriptive mineralogy, in most cases an estimation of the compositions of these minerals from the measurement of physical properties, X-ray powder diffraction data and the presentation of 21 new chemical analyses of pure mineral separates. This includes five analyses of clivine, five of orthopyroxene, eight of garnet, one of chrome diopside and two of omphacite. The results of the investigation have shown that the peridotites consist essentially of forsterite and enstatite with minor or trace amounts of one or more of pyrope-rich garnet, chrome diopside, chrome spinel, phlogopite and rarely graphite, and often exhibit features consistent with plastic movement and tectonic deformation. The peridotites are believed to be derived from an ultrabasic upper mantle, which is both chemioally and physically zoned. The eclogite xenoliths, which are composed mainly of pyrope-almandine garnet and omphacitic clinopyroxene and occasionally contain kyanite, corundum and diamond, are not samples of a primary eclogitic upper mantle nor the products of an eclogite fractionation related to kimberlite genesis. Chemically they are not typical of extrusive basalts and probably either represent pockets of partially fractionated basic magma trapped at mantle-level in an eclogite-stable environment or samples of high-grade crustal metamorphic eclogite accidentally incorporated into the Roberts Victor kimberlite.
- Full Text:
- Date Issued: 1972
A phenological and bioclimatic analysis of honey yield in South Africa
- Authors: Illgner, Peter Mark
- Date: 2004
- Subjects: Bee culture -- South Africa -- Statistics Honeybee -- South Africa Bee culture -- South Africa -- Management Honey plants -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5813 , http://hdl.handle.net/10962/d1007153
- Description: This study has investigated the interaction between honeybees and their forage plants and the impact of selected climatic variables on honey production in South Africa. Twenty-seven scale-hive records from 25 localities have been used as a measure of colony honey reserves. At least 944 plant species are visited by honeybees in South Africa for their nectar and/or pollen, with more than half providing both rewards. The entire honeybee flora encompasses 532 genera and 137 families. The flowering phenologies of the different reward categories of the indigenous forage plants are all significantly and positively correlated at the 0.05 level. Similarly, species offering both rewards are significantly and positively correlated with the flowering phenology of the null flora. The same results were obtained for correlations between the different reward categories of the exotic forage plants in South Africa. Of the 30 species pairs which fulfilled the criteria for selection, 23 occurred in sympatry, 5 in allopatry and 2 in possible parapatry. There is evidence for both competition and facilitation within different indigenous species pairs. The lack of geographical correlation in the intra-annual variation in honey stores and the near absence of any statistically significant (p < 0.05) honey related intra-annual intracolonial correlations may indicate that the former is more important than the latter for the determination of the level of honey reserves within a colony. Only one statistically significant correlation was found between either scale-hive record from the University of Pretoria Experimental Farm and any of the selected climatic variables. A one month lag period and/or possible seasonal effects were detected for each variable, with the exception of the duration of sunshine, in the autocorrelation analyses. A possible 12 month seasonal period was also identified in the single series fourier analyses for a number of variables. Similarly, 12 months was also the most frequently recurring period in the crossspectral results for the one scale-hive record (H42). Any activities which have an impact on the landscape have the potential to affect honeybees and/or their forage plants. Honeybee crop or plant pollination may also enhance yields for commercial farmers and facilitate rural food security.
- Full Text:
- Date Issued: 2004
A phenomenological explication of dream interpretation among rural and urban Nguni people
- Authors: Schweitzer, Robert David
- Date: 1984
- Subjects: Nguni (African people) -- Religion Nguni (African people) -- Psychology Dreams Dreams -- Psychological aspects Healing -- South Africa -- Religious aspects
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3125 , http://hdl.handle.net/10962/d1006189
- Description: Psychologists investigating dreams in non-Western cultures have generally not considered the meanings of dreams within the unique meaning-structure of the person in his or her societal context. The majority of dream studies in African societies are no exception. Researchers approaching dreams within rural Xhosa and Zulu speaking societies have either adopted an anthropological or a psychodynamic orientation. The latter approach particularly imposes a Western perspective in the interpretation of dream material. There have been no comparable studies of dream interpretation among urban blacks participating in the African Independent Church Movement. The present study focuses on the rural Xhosa speaking people and the urban black population who speak one of the Nguni languages and identify with the African Independent Church Movement. The study is concerned with understanding the meanings of dreams within the cultural context in which they occur. The specific aims of the study are: 1. To explicate the indigenous system of dream interpretation as revealed by acknowledged dream experts. 2. To examine the commonalities and the differences between the interpretation of dreams in two groups, drawn from a rural and urban setting respectively. 3. To elaborate upon the life-world of the participants by the interpretations gained from the above investigation. One hundred dreams and interpretations are collected from two categories of participants referred to as the Rural Group and the Urban Group. The Rural Group is made up of amagqira [traditional healers] and their clients, while the Urban Group consists of prophets and members of the African Independent Churches. Each group includes acknowledged dream experts. A phenomenological methodology is adopted in explicating the data. The methodological precedure involves a number of rigorous stages of explication whereby the original data is reduced to Constituent Profiles leading to the construction of a Thematic Index File. By searching and reflecting upon the data, interpretative themes are identified. These themes are explicated to provide a rigorous description of the interpretative-reality of each group. Themes explicated within the Rural Group are: the physiognomy of the dreamer's life- world as revealed by ithongo, the interpretation of ithongo as revealed through action, the dream relationship as an anticipatory mode-of-existence, iphupha as disclosing a vulnerable mode-of-being, human bodiliness as revealed in dream interpretations and the legitimation of the interpretative-reality within the life-world. Themes explicated within the Urban Group are : the physiognomy of the dreamer's life-world revealed in their dream-existence, the interpretative-reality revealed through the enaction of dreams, tension between the newer Christian-based cosomology and the traditional cultural-based cosmology, a moral imperative, prophetic perception and human bodiliness, as revealed in dream interpretations and the legitimation of the interpretative-reality within the life-world. The essence of the interpretative-reality of both groups is very similar and is expressed in the notion of relatedness to a cosmic mode-of-being. The cosmic mode-of-being includes a numinous dimension which is expressed through divine presence in the form of ancestors, Holy Spirit or God. These notions cannot be apprehended by theoretical constructs alone but may be grasped and given form in meaning-disclosing intuitions which are expressed in the lifeworld in terms of bodiliness, revelatory knowledge, action and healing. Some differences between the two groups are evident and reveal some conflict between the monotheistic Christian cosmology and the traditional cosmology. Unique aspects of the interpetative-reality of the Urban Group are expressed in terms of difficulties in the urban social environment and the notion of a moral imperative. It is observed that cultural self-expression based upon traditional ideas continues to play a significant role in the urban environment. The apparent conflict revealed between the respective cosmologies underlies an integration of traditional meanings with Christian concepts. This finding is consistent with the literature suggesting that the African Independent Church is a syncretic movement. The life-world is based upon the immediate and vivid experience of the numinous as revealed in the dream phenomenon. The participants' approach to dreams is not based upon an explicit theory, but upon an immediate and pathic understanding of the dream phenomenon. The understanding is based upon the interpreter's concrete understanding of the life-world, which includes the possibility of cosmic integration and continuity between the personal and transpersonal realms of being. The approach is characterized as an expression of man's primordial attunement with the cosmos. The approach of the participants to dreams may not be consistent with a Western rational orientation, but nevertheless, it is a valid approach. The validity is based upon the immediate life-world of experience which is intelligible, coherent, and above all, it is meaning-giving in revealing life-possibility within the context of human existence.
- Full Text:
- Date Issued: 1984
A phenomenological hermeneutic investigation into the psychoanalytic psychotherapist's experience of using the psychoanalytic couch
- Authors: Milton, Christopher
- Date: 2004
- Subjects: Freud, Sigmund, 1856-1939 -- Criticism and interpretation Psychoanalysis Psychotherapy Psychotherapy -- Methods
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3162 , http://hdl.handle.net/10962/d1007655
- Description: The aim of this study was to describe and critically explore the psychoanalytic, psychotherapist's lived experience of the technique of using the couch. Through examination of the literature a question was formulated that would disclose the analyst's experience of the technique of using the couch. Four experienced psychoanalytic practitioners who could be operationally defined as 'analysts' were interviewed. Using a phenomenological method the protocols were comprehensively analyzed to produce descriptions of the general structure of the experience. These were then texturally enhanced using interleaved direct citations from the interviews. The structural and textural 'findings ' so produced were then hermeneutically dialogued with contemporary psychoanalytic notions of critical discourse and intersubjectivity. The phenomenological ' findings ' of the study disclosed the meaning of the couch as context-based, paradoxical and ambiguous. The couch was found to be a symbol of the analyst as analyst and the process as authentic analysis. Furthermore, at its best, the couch was found to mediate a mode of being that is containing and intimate and in which psychological life may be evoked, tracked and interpreted. The most significant contributor to this mode of being was found to be privacy, which, in particular, helps the analyst maintain an analytic attitude. The couch was also found to be significantly implicated in the generation of an intersubjective analytic third and to support reverie. These 'findings' were hermeneutically dialogued with literature on the couch as well as contemporary psychoanalytic theoretical notions. The dialogue fell into three foci. The first focus entailed deconstructing the meaning of the couch as context-based and ambiguous and not essential. The second pursued critiques of the role that the couch plays in domination, of its function as a symbol/evocative object and of the way in which it shapes being-together, bodily attunement, privacy, the intersubjective analytic third and reverie. Finally the 'findings' were critically examined in terms of both Lacan's notion 'analytic discourse ' and its role in revealing/concealing the analysand as subject. The study concludes with an examination of its own limitations and suggestions for further research.
- Full Text:
- Date Issued: 2004
A phenomenological investigation into educational leaders' perceptions of themselves, their followers, and their organisational contexts
- Authors: Van der Mescht, Hennie
- Date: 1997
- Subjects: Educational leadership -- Psychological aspects
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1697 , http://hdl.handle.net/10962/d1003580
- Description: Leadership is a richly researched ana widely covered topic, attracting the attention of virtually every discipline within the human sciences. Research which focuses on leadership within an educational context is, however, a relatively recent development. Most of the leadership research conducted in this century has been driven by the needs of industry. Consequently, leadership theories have tended to emphasise the instrumentality, measurability and effectiveness of leadership. Leadership models, intent on being prescriptive and 'learnable', have been inclined to oversimplify the complexity of the leadership phenomenon. Another factor which accounts for these features is the research approach adopted by researchers, which has largely been positivistic. This study is an attempt to investigate the underlying dynamics of educational leadership. It is an in-depth study of five educational leaders' perceptions of themselves as leaders, of the people with whom they interact, and of the organisations within which they work. The study is conducted along the lines suggested by phenomenology, a highly qualitative, anti-positivistic research approach, which encourages the researcher to set aside pre-conceived notions of the phenomenon, and to describe what is found exactly as it presents itself. My findings have highlighted a wide and richly varied range of psychological, emotional and cultural factors which seem to play significant roles in how leaders perceive themselves, others and their environments. Most of these factors have been either entirely ignored or very scantily covered in mainstream leadership literature. Educational leadership emerges as a complex, virtually undefinable phenomenon; new and challenging research approaches and methods have the potential for increasing our understanding of how leaders lead, which in turn will have implications for leadership education and selection.
- Full Text:
- Date Issued: 1997
A phenomenological investigation into lecturers' understanding of themselves as assessors at Rhodes University
- Authors: Grant, Rose
- Date: 2005
- Subjects: Curriculum-based assessment -- South Africa Education, Higher -- South Africa -- Evaluation Educational tests and measurements -- South Africa Education, Higher -- Evaluation Case studies Universities and colleges -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1315 , http://hdl.handle.net/10962/d1003948
- Description: This thesis sets out to obtain an understanding of what it means to be an assessor in higher education, more especially within the Rhodes University context. The concept of assessment, a highly contentious and complex issue, is examined against a background of competing understandings of the nature and purpose of higher education, including the striving for excellence versus the call to more equitable ideals associated with a mass higher education and training system. An overview of salient issues is presented in which both traditional and alternative paradigms of measurement and assessment theory are explored with a view to considering foundational principles upon which sound assessment practice should be based. Specific methods and instruments of assessment are examined with the purpose of evaluating their potential for empowering students as active participants in their own learning and in the assessment process. In a field in which much of the literature seeks improved assessment merely through the administration of increasingly sophisticated assessment techniques, a phenomenological investigation offered a unique way of understanding the meaning assessors make of their practice. Making use of in-depth interviews with five lecturers at Rhodes University the researcher, interacting in a personal manner with people not viewed as experimental objects but as human subjects, assisted participants in moving towards non-theoretical descriptions that accurately reflected their experience. Insights contained in the data were synthesised and integrated into a consistent description of the essential nature of the experience, the primary endeavour of the phenomenologist being to transform naïve experience into more explicitly detailed conceptual knowledge. The essence of how these educators understand themselves as assessors at Rhodes University is perhaps best encapsulated by a considerable sense of agency or initiative on their part. While participants make use of a variety of assessment strategies, they are conscious that assessment cannot be viewed in isolation from other aspects of their teaching and the curriculum. Not only do they make use of different assessment methods but, conscious of accommodating the diverse needs of students, understand their responsibility in terms of providing learning opportunities to assist students in meeting the course outcomes and fulfilling their potential. Rather than allowing pressures from within and outside of the academy to dictate, these lecturers, with significant hard work, courage and a capacity for reflective practice, have embraced the challenges associated with higher education in a state of transition.
- Full Text:
- Date Issued: 2005
A phenomenological investigation into the psychoanalytic psychotherapist's experience of identifying, differentiating and processing the patient's transference-based and reality-oriented reactions
- Authors: Danilewitz, Larry Mark
- Date: 1993
- Subjects: Reality therapy Transference (Psychology) -- Therapeutic use
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:2960 , http://hdl.handle.net/10962/d1002469
- Description: The aim of this study was to describe the psychoanalytically-oriented therapist's experience of identifying, differentiating and processing the patient's transference-based and reality-oriented reactions. In order to investigate the therapist's lived experience of being receptive to the total communication of the patient in the analytic situation, the researcher adopted the empirical phenomenological method. This descriptive and intuitive method grounded the researcher in the concreteness of the everyday life-world of the therapist, and enabled him to explicate the therapist's immediate, pre-theoretical experiences of his patient. The appropriate central research question, formulated to elicit the experience of this phenomenon, emerged through the process of enquiry during the pilot study. Thirteen experienced, psychoanalytically-oriented psychotherapists were interviewed and the five protocols considered most revelatory of the phenomenon under investigation were analyzed in detail. The remaining eight protocols were used to illuminate central themes and to clarify areas of uncertainty during the phase of formal explication. The central findings revealed that the oscillating process of the therapist as he shifts from being immersed in the world of his patient to being in a position of observation and self reflection is the fulcrum around which he evaluates the nature of his patient's communications. During this ongoing process of discrimination, living in duality, the therapist comes to experience himself as a patient scrutinized by his own and his patient's confrontations. His journey of disentanglement, the endeavour to differentiate his responses from his patient's actions, is dependent on his ability to engage in honest selfreflection and to access his pre-theoretical and articulated cognitions of his patient. This allows him to acknowledge his own role in what has unfolded interpersonally and to appropriate his previously denied feelings for and attitudes towards his patient, a prerequisite for the accurate and full appraisal of the nature of his patient's communications. Forsaking fixed judgements, the therapist becomes open to the confluence between the reality-oriented responses and transference-based reactions of his patient. This salient discovery, when dialogued with the literature, reinforced the theories of Greenson and Langs that not all the interactions between the patient and the analyst/therapist are transference-based and that it is therefore imperative that the analyst/therapist reflect on his participation in the analytic situation.
- Full Text:
- Date Issued: 1993
A phenomenological investigation into the psychotherapist's experience of identifying, containing and processing the patient's projective identifications
- Authors: Thorpe, Mark Richard
- Date: 1989
- Subjects: Psychotherapist and patient Psychotherapy Methods
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3071 , http://hdl.handle.net/10962/d1002580
- Description: The aim of the study was to describe the therapist's lived experience of identifying, containing and processing the feelings, thoughts or fantasies evoked in him by the patient's projective identifications. A question which would elicit the experience of this phenomenon was formulated by examining case histories, and modified through the use of individual pilot studies. Fifteen experienced, psychoanalytically oriented psychotherapists were interviewed. The eight psychologically richest accounts were chosen for the study. Using the empirical phenomenological method, the four protocols that most clearly reflected the phenomenon were analysed in detail, while the remaining four were used to clarify areas of uncertainty. Projective identification is conceptualised as the process whereby the patient coerces the therapist to embody an un-appropriated aspect of his (patient's) world. The context of processing a patient's projective identification was discovered to be such that the therapist finds himself coerced to embody an incongruent, unfamiliar, confusing and inauthentic state of being which is consonant with the patient's perception of him. The discomfort of the experience leads the therapist to bring to awareness and thematise his feeling-state. He alternates between avoiding this state of being, which results in conf1ict with the patient and the therapist's own values, and appropriating it, which feels inauthentic. The therapist moves from a position of trying to understand the experience in relation to his own world, to the realisation that it is co-determined by the patient. From a position of reflective distance he re-appropriates aspects of his world that were closed to him while under the influence of the patient, in addition to appropriating previously unowned aspects. The therapist dialogues these appropriations with the invoked feelings, allowing him to differentiate those aspects of his feeling-state which are authentically his from those which are unowned aspects of the patient's aspects of his world that were closed to him while under the influence of the patient, in addition to appropriating previously unowned aspects. The therapist dialogues these appropriations with the invoked feelings, allowing him to differentiate those aspects of his feeling-state which are authentically his from those which are unowned aspects of the patient's world that he has been forced to embody. Through this process the therapist clarifies and gives meaning to his feelings. The therapist fee1s re1ieved and lighter, when in the service of the therapy, he temporarily gives himself over to the patient's experience of him, without feeling drawn to either disowning or appropriating it, while simultaneously remaining open to his own authentic reality. These findings were dialogued with the literature on projective identification.
- Full Text:
- Date Issued: 1989
A phenomenological investigation into undergraduate students' experience of acquiring the discourse of engineering
- Authors: Van Heerden, Karen Ilse
- Date: 2001
- Subjects: Education, Higher -- South Africa Students -- Attitudes Academic writing -- Study and teaching -- South Africa English language -- Rhetoric -- Study and teaching -- South Africa Technical writing -- Study and teaching
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1698 , http://hdl.handle.net/10962/d1003581
- Description: The area of discourse acquisition and writing in higher education has become a much researched field. In South Africa the interest in discourse acquisition and writing has been partly in response to the change in student profile, particularly over the past ten years. While South African researchers and academics are increasingly focusing their interest in discourse acquisition and writing on the unique circumstances here, they rely on theories based on research done in very different social contexts. These theories are not necessarily universally appropriate. South Africa is currently undergoing a period of transformation in higher education aimed at greater access and equity for black students and academics. The accompanying sense of frustration and disillusionment among students and academics underlines the need to reappraise all aspects of higher education. Much of the research on discourse acquisition and writing is undertaken in arts programmes: vocational fields - such as engineering education - tend to be neglected. If the envisaged growth in science and engineering education is to be realised, it is essential that research in discourse and writing be undertaken in engineering programmes. This study investigates discourse acquisition as experienced by students in a South African engineering faculty. The experiences of six final year technikon students are investigated to gain a better understanding of what it means to acquire the discourse of engineering. The phenomenological method used requires that the researcher suspends or brackets a priori theoretical notions or pre-conceptions so that that which the students experience, rather than what the researcher expects in terms of theory, can emerge. What emerges from the students' experiences is partially congruent with established discourse and writing theories. However, some of the student experiences of discourse acquisition differ in significant ways from what is described in mainstream writing and discourse acquisition theory. The differences in the manner in which these students experience their acquisition of engineering discourse leads to a new understanding of the phenomenon. The students do not experience the alienation or struggle described in mainstream theoretic accounts of discourse acquisition. Students' approaches to writing are affected by their awareness of their multiple identities and the different locations in which they learn. Their approaches to writing are significantly different in some respects from descriptions in mainstream theories in some respects. The description of their experiences gives a different understanding of what it means to acquire the discourse of engineering, and may contribute to the reappraisal of engineering education in a contemporary South African context.
- Full Text:
- Date Issued: 2001
A phenomenological study of how South African entrepreneurs experience and deal with ethical dilemmas
- Authors: Robinson, David Alan
- Date: 2003
- Subjects: Entrepreneurship -- South Africa Business ethics -- South Africa Decision making -- Moral and ethical aspects
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1175 , http://hdl.handle.net/10962/d1002791
- Description: This research sets out to examine how entrepreneurs experience and deal with ethical dilemmas. An entrepreneur is defined as a person who creates something of value and assumes the risk of establishing and managing a business around it. An ethical dilemma comes about when the entrepreneur must choose between alternatives and where the morally correct choice is unclear. This may be due to conflicting personal values or loyalties, tensions arising out of the realization that the moral action is not in line with his self-interest, cross-cultural conflict, or moral ambiguity. Because of the nature of entrepreneurship, the entrepreneur typically lives with ever-present threats arising from limited resources, competition, and the risk of business failure. His actions must simultaneously ensure survival, maximize profit, limit risk, counter threats, optimize the use of resources, and reward him with a feeling of satisfaction. It is hardly surprising that conflicting priorities sometimes ensue. It is also widely believed that these entrepreneurial pursuits supersede the more general need to act in morally appropriate ways. This is a phenomenological study, based on interviews with seven entrepreneurs in established service-oriented ventures. They were asked to describe their business, any dilemmas they have experienced, how they were handled, and what challenges they experience as entrepreneurs in South Africa today. Using phenomenology as my vehicle for data collection and analysis, I sought to enter the lived-worlds of my participants to discover the essence of how ethical dilemmas are experienced in the entrepreneurial milieu. The study’s findings reflect that each entrepreneur has a distinctive world-view, which is represented by a complex mosaic of virtue ethics, deontology, utilitarianism and metaethical perspectives. The permutations are numerous, thus negating the possibility of typecasting entrepreneurs. Instead this research introduces the reader to aspects of entrepreneurial reality such as the complexity of cultural diversity, the freedom to limit the amount of personal energy given to business, and the existence of a more sensitive, searching inner soul beneath the apparent hard-nosed business-oriented public image. While examining entrepreneurial dilemmas in depth, this research introduces the dilemma drum as a tool to portray the argument form of any dilemma by making explicit the ethical component inherent in every business decision and facilitating its effective resolution in a non-prescriptive way. The findings identify certain individual characteristics of participant entrepreneurs that are unlike anything in the mainstream literature, dispelling notions of the entrepreneur as a societal misfit, an essential innovator with vision and flair, or a compulsive risk-taker, while confirming success as the key motivator rather than money per se, the importance of significant others, and the influence of culture and gender. They provide fresh insights into the psyche of the entrepreneur, which include: the existence of inner conviction - marrying the concept of goal-directedness with that of making a contribution to society; exercising the virtues in order to support a delicate balance between business and ethical imperatives; learning to respect energy flow; an alternative morality based on attracting and allowing benevolent or serendipitous events to happen naturally and redefining success as ‘being able to create what is needed as and when needed’; focusing one’s energy on the telos; developing a personal marketing formula suited to a culturallydiverse society; and the anxiety associated with being out-there on one’s own. The general statement, which is ultimately distilled from the seven situated descriptions, introduces a theory of entrepreneurial ethics that presents a new and different view of the lived-world of entrepreneurship, consisting of: Firstly, the key components of entrepreneurial success – having clear goals, energy, making a contribution to society, being connected, getting others on board, and work as an extension of self; secondly, what drives entrepreneurs – goal-orientation, sense of personal excitement, inner conviction, autonomy, and external recognition of success; thirdly, the entrepreneurial ethic – concern for credibility, commitment to service, contributing to quality of life; fourthly, the nature of entrepreneurial dilemmas - conflicting responsibilities, authenticity and credibility, risk and expansion, and awareness of diversity; fifthly, how entrepreneurs deal with ethical issues in their own distinctive ways – by holding fast to authentic virtues, bowing to community expectations, avoiding friction, adopting a ‘come-what-may’ or ‘what’s in it for me’ attitude, or pursuing a higher purpose where both parties benefit; sixthly, entrepreneurs’ world -views – beliefs, goals, ways of deriving satisfaction, virtuous behaviour; pen-ultimately, the challenges facing entrepreneurs in South Africa – overcoming the legacies of apartheid, containing crime, fostering an acceptable business ethic, and facilitating reconciliation between ethnic groups; and lastly, finding the power within – that illusive entrepreneurial spirit – self-reliance, looking beyond immediate obstacles, grasping opportunities, and understanding serendipity.
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- Date Issued: 2003
A phenomenological study of women primary school heads' experiences as educational leaders in post colonial Zimbabwe
- Authors: Muzvidziwa, Irene
- Date: 2013-06-26
- Subjects: Educational leadership -- Zimbabwe Women school administrators -- Zimbabwe School management and organization -- Zimbabwe Women in education -- Zimbabwe
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1949 , http://hdl.handle.net/10962/d1008200
- Description: This research study was carried out in order to gain an understanding of the experiences of women primary school heads, their perceptions of their roles as leaders, the challenges they face and how they dealt with them. The study focused on the lived experiences of five women in Zimbabwe's primary schools. Literature relating to the issues and experiences of women in educational leadership within school contexts and the conceptual framework is examined. The importance of leadership has been emphasised in the literature of school effectiveness. Leadership theories tended to emphasise measurability and effectiveness of leadership, oversimplifying the complexity of leadership phenomenon. These features reflect research approach adopted by researchers from a positivist orientation. This study is an in-depth qualitative study conducted along the lines suggested by a phenomenological-interpretivist design with emphasis on rich contextual detail, close attention to individual's lived experience and the bracketing of pre-conceived notions of the phenomenon. Views and experiences based on the participants' perspectives are described through in-depth interviews which were dialogical in nature. Through this approach, I managed to grasp the essences of the lived experiences of women The research highlights the women's perceptions of themselves as educational leaders. What emerges is the variety of approaches to handling challenges. My findings show a rich and diverse culture of creativity in the way participants adopted a problem-solving strategy, which is not reflected in the mainstream leadership. Though educational leadership emerges as a complex phenomenon, with alternative approaches to educational research, there is high potential for increased understanding of woman's leadership, its importance and implications for school. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
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A physico-chemical investigation of refractory hard metals
- Authors: Philip, Hamish Ian
- Date: 1973
- Subjects: Refractory materials Heat resistant alloys
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4441 , http://hdl.handle.net/10962/d1007630
- Description: In this investigation, the resistivity of vanadium nitride at elevated temperatures has been measured using a resistance bridge based on the Dauphinée/Mooser (1955) chopper system. In general, an almost linear increase of resistivity with temperature was observed for VN, but at certain temperatures, deviations from linearity (anomalies) were observed, these have been classified into three types. Attempts have been made to correlate the anomalous behaviour and temperature coefficients of resistivity with the ambient atmospheres and with the impurities, (especially oxygen), stoichiotmetry and density of this material. Oxygen and excess nitrogen appear to be electron donors in their effects on VN and result in a decrease in the slope of resistivity vs temperature curves. Oxygen and excess nitrogen also appear to increase the overall resistivity due to an increase in defect concentration. No effects due to the ambient atmosphere have been observed in the case of hot-pressed samples. lndicating that reaction can only occur if the reacting gases can reach the interior of the samples.
- Full Text:
- Date Issued: 1973
A physiological study on a commercial reef fish to quantify the relationship between exploitation and climate change resilience
- Authors: Duncan, Murray Ian
- Date: 2019
- Subjects: Chrysoblephus laticeps -- Climatic factors , Chrysoblephus laticeps -- Physiology , Sparidae -- South Africa -- Climatic factors , Reef fishes -- South Africa -- Climatic factors , Fish populations -- South Africa -- Climatic factors , Fish populations -- Measurement , Fish populations -- Monitoring , Fisheries -- South Africa -- Environmental aspects , Ocean temperature -- Physiological effect -- South Africa
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/76541 , vital:30599
- Description: The persistence of harvested fish populations in the Anthropocene will be determined, above all, by how they respond to the interacting effects of climate change and fisheries exploitation. Predicting how populations will respond to both these threats is essential for any adaptive and sustainable management strategy. The response of fish populations to climate change is underpinned by physiological rates and tolerances, and emerging evidence suggests there may be physiological-based selection in capture fisheries. By quantifying important physiological rates of a model species, the endemic seabream, Chrysoblephus laticeps, across ecologically relevant thermal gradients and from populations subjected to varying intensities of commercial exploitation, this thesis aimed to 1) provide the first physiologically grounded climate resilience assessment for a South African linefish species, and 2) elucidate whether exploitation can drive populations to less physiologically resilient states in response to climate change. To identify physiologically limiting sea temperatures and to determine if exploitation alters physiological trait distributions, an intermittent flow respirometry experiment was used to test the metabolic response of spatially protected and exploited populations of C. laticeps to acute thermal variability. Exploited populations showed reduced metabolic phenotype diversity, fewer high-performance aerobic scope phenotypes, and a significantly lower aerobic scope curve across all test temperatures. Although both populations maintained a relatively high aerobic scope across a wide thermal range, their metabolic rates were compromised when extreme cold events were simulated (8 °C), suggesting that predicted future increases in upwelling frequency and intensity may be the primary limiting factor in a more thermally variable future ocean. The increment widths of annuli in the otoliths of C. laticeps from contemporary and historic collections were measured, as a proxy for the annual growth rate of exploited and protected populations. Hierarchical mixed models were used to partition growth variation within and among individuals and ascribe growth to intrinsic and extrinsic effects. The best model for the protected population indicated that the growth response of C. laticeps was poorer during years characterised by a high cumulative upwelling intensity, and better during years characterised by higher mean autumn sea surface temperatures. The exploited population growth chronology was too short to identify an extrinsic growth driver. The growth results again highlight the role of thermal variability in modulating the response of C. laticeps to its ambient environment and indicate that the predicted increases in upwelling frequency and intensity may constrain future growth rates of this species. A metabolic index (ϕ), representing the ratio of O2 supply to demand at various temperatures and oxygen concentrations, was estimated for exploited and protected populations of C. laticeps and used to predict future distribution responses. There was no difference in the laboratory calibrations of ϕ between populations, and all data was subsequently combined into a single piecewise (12 °C) calibrated ϕ model. To predict the distribution of C. laticeps, ϕ was projected across a high-resolution ocean model of the South African coastal zone, and a species distribution model implemented using the random forest algorithm and C. laticeps occurrence points. The future distribution of C. laticeps was estimated by predicting trained models across ocean model projections up to 2100. The best predictor of C. laticeps’ current distribution was minimum monthly ϕ and future predictions indicated only a slight range contraction on either edge of C. laticeps’ distribution by 2100. In order to provide policy makers, currently developing climate change management frameworks for South Africa’s ocean, with a usable output, the results of all research chapters were combined into a marine spatial model. The spatial model identified areas where C. laticeps is predicted to be resilient to climate change in terms of physiology, growth and distribution responses, which can then be prioritised for adaptation measures, such as spatial protection from exploitation. While these results are specific to C. laticeps, the methodology developed to identify areas of climate resilience has broad applications across taxa. From a global perspective, perhaps the most salient points to consider from this case study are the evidence of selective exploitation on physiological traits and the importance of environmental variability, rather than long-term mean climate changes, in affecting organism performance. These ideas are congruent with the current paradigm shift in how we think of the ocean, selective fisheries, and how they relate to organism climate resilience.
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- Date Issued: 2019
A political discourse analysis of social memory, collective identity and nation-building in the Sunday Mail and the Standard of Zimbabwe between 1999 and 2013
- Authors: Santos, Phillip
- Date: 2017
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/41753 , vital:25130
- Description: Although much effort has been expended on studying many sites of social memory, little attention has been directed at the media’s work of memory, especially in post-colonial Africa. The media’s work of memory is important because of its social standing as a communicative and cultural institution, and because social memory is imbricated in processes of both collective identity formation and nation-building which partly shape patterns of economic distribution, recognition, and representation in society. It is in this context that this study shows how Zimbabwe’s The Sunday Mail and The Standard newspapers used social memory to construct the country’s national identity between 1999 and 2013 in the context of a socio-economic and political crisis for the country’s poly-racial, and poly-ethno-linguistic communities. The study also explores how these newspapers worked as memory sites through their construction of Zimbabwe’s national identity during the period under study. It achieves these tasks by analysing how these newspapers reported on such issues as Zimbabwe’s colonial history, the country’s narrative of decolonisation, the Gukurahundi narrative, the land reform process, elections and independence celebrations. The study takes a critical realist approach to qualitative research, and uses Fairclough and Fairclough’s (2012) method of political discourse analysis as well as Aristotle’s approach to rhetoric for a close reading of the sampled newspaper articles. It is informed by Nancy Fraser’s Theory of Justice, Chantal Mouffe’s Model of Agonistic Pluralism, and Jurgen Habermas’s Discourse Ethics Theory. The study concludes that these two newspapers actively use social memory to construct versions of national identity for specific socio-political and economic ends. Editorials and opinions from The Sunday Mail, which construct Zimbabwean-ness in nativist terms represent the hegemonic appropriation of social memory to construct a sense of Zimbabwean nationhood. In contrast, The Standard uses social memory to construct Zimbabwean-ness in modernist terms with citizenship as the core organising principle of belonging. The political discourse analysis of The Sunday Mail’s and The Standard’s evocation of social memory shows that the two newspapers reflect the tension between indigenist and universalist imaginaries of belonging in Zimbabwe. But the newspapers’ construction of belonging in Zimbabwe is informed by justice claims as seen from each of their political standpoints. As such, their respective definitions of Zimbabweans’ justice claims in terms of their political standpoints, also propose how those justice claims should be addressed and who stands to benefit from them.
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- Date Issued: 2017
A preliminary examination of selected biological links between four Eastern Cape estuaries and the inshore marine environment
- Authors: Vorwerk, Paul D
- Date: 2007
- Subjects: Estuaries -- South Africa -- Eastern Cape Marine fishes -- South Africa -- Eastern Cape Marine ecology -- South Africa -- Eastern Cape Estuarine ecology -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5747 , http://hdl.handle.net/10962/d1005434
- Description: The coastal transition zone (CTZ), which links the terrestrial and marine environments, has been identified as a region of high biological diversity and elevated production. Results of studies conducted in the northern hemisphere indicate that the links between estuaries and the adjacent marine environment is critical to ecological functioning within the CTZ. This study assessed the influence of selected estuaries with different hydrodynamic characteristics on the adjacent marine environment along the south-eastern coastline of southern Africa. Four estuaries were examined, including two permanently open systems, the fresh water deprived Kariega and fresh water dominated Great Fish, and two temporarily open/closed estuaries (TOCE), the Kasouga and East Kleinemonde. Results of the study indicated that outflow of estuarine water from the Great Fish Estuary contributed to a plume of less saline water being evident within the adjacent marine environment. The plume of water was associated with increased zooplankton biomass and particulate organic matter (POM) and chlorophyll-a concentrations. Adjacent to the Kariega Estuary, no evidence of fresh water outflow into the marine environment was observed. However, in the sea directly opposite the mouth of the estuary an increase in zooplankton abundance and biomass was evident. Results of numerical analyses indicated that the increase in zooplankton abundance observed adjacent to the mouth of both permanently open estuaries could not be attributed to the export of zooplankton from the estuary, but rather the accumulation of marine species within the region. The mechanisms responsible for this accumulation were not determined, but it was thought to be associated with increased food availability in the estuarine frontal zone. A similar, but less dramatic biological response was also observed in the marine environment adjacent to the two TOCEs. It is suggested that the increase in biological activity within these regions could be ascribed to seepage of estuarine or ground water through the sand bar that separates these estuaries from the sea. Results of stable carbon isotope analyses indicated that both the Great Fish and Kariega estuaries exported carbon to the nearshore marine environment. The area influenced by estuarine derived carbon was dependent on the volume of estuarine outflow to the marine environment. Adjacent to the fresh water dominated Great Fish Estuary, estuarine derived carbon was recorded up to 12km from the mouth, while adjacent to the fresh water deprived Kariega, estuarine derived carbon was only evident directly opposite the mouth. The recruitment of macrozooplankton (> 2cm) into the fresh water deprived Kariega Estuary was in the range recorded for other permanently open southern African estuaries with higher fresh water flow rates. This indicates that the mechanisms which allow estuarine dependent larvae to locate and enter estuaries are not related to fresh water inflow. In conclusion, this study has demonstrated that despite their small size relative to European and North American systems, South African permanently open and temporarily open/closed estuaries also influence biological activity within the adjacent nearshore marine environment.
- Full Text:
- Date Issued: 2007