Hsp90α/β associates with the GSK3β/axin1/phospho-β-catenin complex in the human MCF-7 epithelial breast cancer model:
- Authors: Cooper, Leanne C , Prinsloo, Earl , Edkins, Adrienne L , Blatch, Gregory L
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165096 , vital:41208 , DOI: 10.1016/j.bbrc.2011.08.136
- Description: Hsp90α/β, the signal transduction chaperone, maintains intracellular communication in normal, stem, and cancer cells. The well characterised association of Hsp90α/β with its client kinases form the framework of multiple signalling networks. GSK3β, a known Hsp90α/β client, mediates β-catenin phosphorylation as part of a cytoplasmic destruction complex which targets phospho-β-catenin to the 26S proteasome. The canonical Wnt/β-catenin pathway promotes stem cell self-renewal as well as oncogenesis. The degree of Hsp90α/β involvement in Wnt/β-catenin signalling needs clarification. Here, we describe the association of Hsp90α/β with GSK3β, β-catenin, phospho-β-catenin and the molecular scaffold, axin1, in the human MCF-7 epithelial breast cancer cell model using selective inhibition of Hsp90α/β, confocal laser scanning microscopy and immunoprecipitation. Our findings suggest that Hsp90α/β modulates the phosphorylation of β-catenin by interaction in common complex with GSK3β/axin1/β-catenin.
- Full Text:
- Date Issued: 2011
Human DNAJ in cancer and stem cells:
- Authors: Sterrenberg, Jason N , Edkins, Adrienne L , Blatch, Gregory L
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165118 , vital:41210 , DOI: 10.1016/j.canlet.2011.08.019
- Description: The heat shock protein 40 kDa (HSP40/DNAJ) co-chaperones constitute the largest and most diverse sub-group of the heat shock protein (HSP) family. DNAJ are widely accepted as regulators of HSP70 function, but also have roles as co-chaperones for the HSP90 chaperone machine, and a growing number of biological functions that may be independent of either of these chaperones. The DNAJ proteins are differentially expressed in human tissues and demonstrate the capacity to function to both promote and suppress cancer development by acting as chaperones for tumour suppressors or oncoproteins. We review the current literature on the function and expression of DNAJ in cancer, stem cells and cancer stem cells. Combining data from gene expression, proteomics and studies in other systems, we propose that DNAJ will be key regulators of cancer, stem cell and possibly cancer stem cell function. The diversity of DNAJ and their assorted roles in a range of biological functions means that selected DNAJ, provided there is limited redundancy and that a specific link to malignancy can be established, may yet provide an attractive target for specific and selective drug design for the development of anti-cancer treatments.
- Full Text:
- Date Issued: 2011
I love laser : it's my guiding light
- Authors: Nolan, Cathy
- Date: 2011
- Subjects: Nyokong, Tebello
- Language: English
- Type: Article , text
- Identifier: vital:7184 , http://hdl.handle.net/10962/d1006274 , http://unesdoc.unesco.org/images/0019/001906/190645e.pdf#190680 , Nyokong, Tebello
- Description: What is the common thread that could possibly link denim jeans, cancer and pesticides? None is evident. Yet when South African chemist Tebello Nyokong describes her fascinating research, the link that emerges is light. Nyokong, a specialist in nanochemistry, loves laser, and is using it in ways that could have a revolutionary impact on medicine and the environment.
- Full Text:
- Date Issued: 2011
Imbali
- Authors: Bani, Zanemali , AmaJobe Traditional Community
- Date: 2011
- Subjects: Bani, Zanemali Jobe (African people) -- South Africa -- Peddie -- History Tarfield Location (Peddie, South Africa) Benton Location (Peddie, South Africa) Mqheleni Location (Peddie, South Africa) Xhosa (African people) -- South Africa -- Peddie Fort Peddie (South Africa) -- History
- Language: Xhosa
- Type: text
- Identifier: http://hdl.handle.net/10962/41271 , vital:25073 , This manuscript is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017. , PR 10 353
- Description: Historic record of AmaJobe community drafted by Chief Zanemali Bani. AmaJobe sisizwe kwizizwe zamaXhosa esinomlando waso osafumaneka ngokucacileyo kwisizukulwane seshumi elinesine. UNkosi Sinuka, isizukulwane sesibhozo ukusuka kwinkosi uZanemali ophetheyo, yabanguye owagqwesayo, ekhona kumlo ophakathi koCirha noTshawe ngaseMzimvubu River phambi ko 1600. Ngeloxesha esisizwe samaJobe sasele sikho kade kweli lamaXhosa njengesizwe samaJobe. Kwakukho izizwe zamaRhudulu , amaGqubusha, amaJobe asondele kakhulu kwisiduko samaNgwevu, in fact uSinuka ngumkhuluwa kaTshangisa and uncle to Rhudulu. , Historic record of AmaJobe community drafted by Chief Zanemali Bani. AmaJobe is one of the most ancient traditional communities in the Eastern Cape, being able to trace their history back fourteen generations. Chief Sinuka, eight generations before Zanemali, the present chief was present at the battle between Tshawe and Cirha at the Mzimvubu river, during which battle amaJobe participated on behalf of Tshawe. This battle occurred some time before the year 1600, by which time amaJobe were already a distinct traditional community. The amaJobe are closely related to the amaNgwevu clan, in fact Sinuka was the senior brother of Tshangisa and the uncle to Rhudulu. , Bani, Zanemali, Chief (donor)
- Full Text:
- Date Issued: 2011
Imbali (unedited version)
- Authors: Bani, Zanemali , AmaJobe Traditional Community
- Date: 2011
- Subjects: Bani, Zanemali Jobe (African people) -- South Africa -- Peddie -- History Tarfield Location (Peddie, South Africa) Benton Location (Peddie, South Africa) Mqheleni Location (Peddie, South Africa) Xhosa (African people) -- South Africa -- Peddie Fort Peddie (South Africa) -- History
- Language: Xhosa
- Type: text
- Identifier: http://hdl.handle.net/10962/41286 , vital:25075 , This manuscript is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017. , PR 10 353
- Description: Historic record of AmaJobe community drafted by Chief Zanemali Bani. AmaJobe sisizwe kwizizwe zamaXhosa esinomlando waso osafumaneka ngokucacileyo kwisizukulwane seshumi elinesine. UNkosi Sinuka, isizukulwane sesibhozo ukusuka kwinkosi uZanemali ophetheyo, yabanguye owagqwesayo, ekhona kumlo ophakathi koCirha noTshawe ngaseMzimvubu River phambi ko 1600. Ngeloxesha esisizwe samaJobe sasele sikho kade kweli lamaXhosa njengesizwe samaJobe. Kwakukho izizwe zamaRhudulu , amaGqubusha, amaJobe asondele kakhulu kwisiduko samaNgwevu, in fact uSinuka ngumkhuluwa kaTshangisa and uncle to Rhudulu. , Historic record of AmaJobe community drafted by Chief Zanemali Bani. AmaJobe is one of the most ancient traditional communities in the Eastern Cape, being able to trace their history back fourteen generations. Chief Sinuka, eight generations before Zanemali, the present chief was present at the battle between Tshawe and Cirha at the Mzimvubu river, during which battle amaJobe participated on behalf of Tshawe. This battle occurred some time before the year 1600, by which time amaJobe were already a distinct traditional community. The amaJobe are closely related to the amaNgwevu clan, in fact Sinuka was the senior brother of Tshangisa and the uncle to Rhudulu. , Bani, Zanemali, Chief (donor)
- Full Text:
- Date Issued: 2011
In service to the law: Alastair James Kerr SC
- Authors: Glover, Graham B
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/70658 , vital:29686 , https://hdl.handle.net/10520/EJC53959
- Description: Professor Alastair James Kerr SC passed away at Settlers Hospital in Grahamstown on the 29th of September 2010. He was eighty-eight years of age. Ironically, his death occurred at the time that the third part of the 2010 SALJ appeared in print, containing a tribute to one of the other great writers on South African contract law, Professor Richard (Dick) Christie, who had passed away earlier in the year (see A J G Lang 'Professor Richard Hunter Christie: A memorial tribute' (2010) 127 SALJ 414). 2010 may have been a momentous year in South Africa for many reasons, but the deaths of these two men in the same year has left the landscape of our contract law irrevocably changed, even though their ideas will live on through their published works.
- Full Text: false
- Date Issued: 2011
In vitro toxicity testing of zinc tetrasulfophthalocyanines in fibroblast and keratinocyte cells for the treatment of melanoma cancer by photodynamic therapy
- Authors: Maduray, Kaminee , Karsten, Alta , Odhay, Bharti , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247588 , vital:51597 , xlink:href="https://doi.org/10.1016/j.jphotobiol.2011.01.020"
- Description: A series of water-soluble tetrasulfonated metallophthalocyanines (MPcs) dyes have been studied to be used as a drug or photosensitizer (PS) in photodynamic therapy (PDT) for the treatment of cancers. During PDT the PS is administrated intravenously or topically to the patient before laser light at an appropriate wavelength is applied to the cancerous area to activate the PS. The activated PS will react with oxygen typically present in the cancerous tissue to generate reactive oxygen species for the destruction of the cancerous tissue. This in vitro study aimed at investigating the cytotoxic effects of different concentrations of zinc tetrasulfophthalocyanines (ZnTSPc) activated with a diode laser (λ = 672 nm) on melanoma, keratinocyte and fibroblast cells. To perform this study 3 × 104 cells/ml were seeded in 24-well plates and allowed to attach overnight, after which cells were treated with different concentrations of ZnTSPc. After 2 h, cells were irradiated with a constant light dose of 4.5 J/cm2. Post-irradiated cells were incubated for 24 h before cell viability was measured using the CellTiter-Blue Viability Assay. Data indicated high concentrations of ZnTSPc (60–100 μg/ml) in its inactive state are cytotoxic to the melanoma cancer cells. Also, results showed that photoactivated ZnTSPc (50 μg/ml) was able to reduce the cell viability of melanoma, fibroblast and keratinocyte cells to 61%, 81% and 83% respectively. At this photosensitizing concentration the efficacy the treatment light dose of 4.5 J/cm2 against other light doses of 2.5 J/cm2, 7.5 J/cm2 and 10 J/cm2 on the different cell lines were analyzed. ZnTSPc at a concentration of 50 μg/ml activated with a light dose of 4.5 J/cm2 was the most efficient for the killing of melanoma cancer cells with reduced killing effects on healthy normal skin cells in comparison to the other treatment light doses. Melanoma cancer cells after PDT with a photosensitizing concentration of 50 μg/ml and a treatment light dose of 4.5 J/cm2 showed certain apoptosis characteristics such as chromatin condensation and fragmentation of the nucleus. This concludes that low concentrations of ZnTSPc activated with the appropriate light dose can be used to induce cell death in melanoma cells with the occurrence of minimal damage to surrounding healthy tissue.
- Full Text:
- Date Issued: 2011
Integrating scholastic and practice-centred epistemologies in a post-graduate professional degree
- Authors: Lotz-Sisitka, Heila , Ellery, Karen
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/69489 , vital:29542 , https://hdl.handle.net/10520/EJC37710
- Description: This article argues for the integration of both scholastic and practice-centred epistemologies within an Environmental Education (EE) post-graduate curriculum that is oriented towards sustainability and socio-ecological justice. It is an interpretive study based on an in-depth analysis of five assignments by four scholars registered for the M.Ed. EE course at Rhodes University where a contextualised, reflexive research process, based in a work-place context, forms the integrative pedagogic tool. Analyses indicate that involving students in such a process, with close support and guidance, is an effective means of developing both scholastic and practical epistemologies. It is concluded that research-led integration of scholastic and practice-centred epistemologies in a transformational curriculum has the potential to provide epistemological access to the academy, advance knowledge within disciplines, and challenge the dominance of scholastic knowledge in higher education settings.
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- Date Issued: 2011
Intellectualisation of African languages with particular reference to isiXhosa
- Authors: Maseko, Pamela
- Date: 2011
- Subjects: Xhosa language -- Study and teaching -- South Africa , Language and education -- South Africa , African languages
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/58035 , vital:27035
- Description: The research explores the relationship between language and education, and motivates for the intellectualisation of African languages, isiXhosa in particular, and for their use in education. The main rationale behind this is that access to, and success in education can largely be realised if that education is mediated in one’s first language. The thesis discusses works of prominent scholars who have written on the subject - relating cognitive abilities and achievement in education to language in which that education is offered. The lack of terminology in new domains in African languages as barrier to mother tongue education is laid bare by looking specifically at the history of intellectualisation of isiXhosa, from the missionaries in the 1820s up to the new endeavours as recently as 2008. Terminologies that were developed during the Bantu Education era, where development of isiXhosa and other indigenous African languages was accelerated in order to respond to the demands of moedertaal-onderwys (mother tongue education) are surveyed, and the process of their development analysed. Three main terminology lists developed during this period are analysed against terminology development principles, approaches and methods that are seen as a measure to ensure quality terminology development. The efforts of the development of isiXhosa during the post-apartheid South Africa, especially the government-driven initiatives, are also critiqued even though these are not as effective and as extensive, especially in education. The result of this analysis is that African languages and isiXhosa in particular, can be used in scientific disciplines and at the highest levels of education. Its grammar is advanced, and its lexicon is extensive such that new concepts that need to be named can be named, using appropriate term creation strategies. There are also technological tools such as WordSmith tools that can be used that can advance its development, ensuring that the concept represented in the newly-created term is precise, concise and appropriate in terms of its discipline. Therefore it is argued that, in the interim, terminologies should be developed, in various subjects, to support learning, which at this stage is mediated in English, for those students who have other languages as mother tongue. Those terminologies that have been developed in the various historical periods should be collated, revised and brought into the classrooms. The thesis argues that real intellectualisation of isiXhosa and other African languages rests on the use of these languages in classrooms and lecture halls, and in the value that all role players place on these languages.
- Full Text:
- Date Issued: 2011
Investigating the impact of capital account liberalization on economic growth: A case study of South Africa
- Authors: Khumalo, Sibanisezwe A. (https://orcid.org/0000-0002-4330-9249)
- Date: 2011
- Subjects: Capital Movements--South Africa , Investment, Foreign--South Africa South Africa , Free Trade--South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/25800 , vital:64486
- Description: The increased interest in capital flows has made it imperative to understand how they impact a particular economy. The Global drive for an interlinked world economy has increased the need for monetary authorities and Governments to able to effectively deal with any negative spins off from capital flows and also be able to take advantage of positive effects capital flows may have on an economy. The study seeks to understand how the change to lift restrictions on capital flows into the South African economy may have impacted on economic growth. The study analyses the relationship that existed between capital flows, that is to say foreign direct investment (FDI) and portfolio investment (P_I) and economic growth under the period of capital controls (1975 Q1 to 1994Q1). Then study will then analyse the same relationship but this time under the liberalised period (1994 Q2 to 2010 Q2) and compare how the long run relationship has changed after capital account liberalisation. The study uses an endogenous model to determine the relationship. The study unlike most will focus on a single economy, which is South Africa and not use panel data like most previous studies. The study found that in the short run capital account liberalising aided economic growth as both FDI and P_I became significant, with positive coefficients and also found that there is long run relationship between economic growth and capital flows. In the long run FDI is significant while P_I is not. After liberalisation FDI adjusted faster in the long run than before liberalisation on its impact on economic output. Also of note was that the study found that under capital controls the conditional variance was constant but after liberalisation the relationship between capital flows and economic growth became more sensitive to negative news and the conditional variance was not constant thus indication of increased volatility. To maximise from opening up of capital accounts the economy should maintain sound macroeconomic policies. This will help shield the economy from the external shocks and this maintain economic growth. , Thesis (MA) -- Faculty of Management and Commerce, 2011
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- Date Issued: 2011
Investigation of homogeneous photosensitized oxidation activities of palladium and platinum octasubstituted phthalocyanines
- Authors: Ogunbayo, Taofeek B , Antunes, Edith M , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/248394 , vital:51682 , xlink:href="https://doi.org/10.1016/j.molcata.2010.11.008"
- Description: Photosensitized oxidation of 4-nitrophenol was studied in organic solutions with seven octasubstituted thio and aryloxy palladium and platinum phthalocyanines acting as photosensitizers. Kinetic studies conducted also showed that the complexes have different singlet oxygen quenching constants with direct implication on the quantum yield of photodegradation of 4-nitrophenol (Φ4-NP). Palladium analogues gave better results than the platinum analogues in terms of Φ4-NP with palladium-(dodecylthio)phthalocyanine giving the highest yield of 1.8 × 10−3. Gas chromatography (GC) and liquid chromatography connected to a mass spectrometer (LC–MS) were used to confirm the photodegradation products which were hydroquinone and 1,4-benzoquinone.
- Full Text:
- Date Issued: 2011
JM Coetzee's Disgrace: a reader's guide, and: JM Coetzee's austerities
- Authors: Marais, Mike
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/144231 , vital:38323 , DOI: 10.2979/reseafrilite.42.4.135
- Description: Like all of the other publications in the series of which it forms a part, Andrew van der Vlies's Disgrace: A Reader's Guide conforms to a set format: a preface, followed by biographical information on the novelist and the context in which he or she wrote the text concerned, and then a longer section comprising a paraphrase and discussion of the work and its reception, together with suggestions for further reading. Despite these structural constraints, van der Vlies provides a very fine introduction to Disgrace in this volume. Readers will find especially insightful his treatment of Coetzee's preoccupation with alterity, and the responsibility, both ethical and aesthetic, that such otherness exacts. One very slight criticism I have of the monograph is that it could have contained more references to discussions of Coetzee's use of narrative point of view in its list of recommended reading. (James Meffan and Kim Worthington's examination of the ambivalent relationship between David Lurie and the narrator's voice comes to mind here, for instance.) Having said this, however, I have little doubt that van der Vlies's guide will prove a useful and comprehensive introduction to Disgrace in university programs.
- Full Text:
- Date Issued: 2011
Journal of learner writing / Phemba Mfundi
- Authors: Nelson Mandela Institute for Education and Rural Development
- Date: 2011
- Subjects: Inkedama -- Ukufa , Protests -- Our roots , Protest -- Praise poems , Oomana -- Women , Umtshato -- Wedding -- Humanities , Ugawulayo -- HIV & AIDS , Indalo -- Nature , Ulawulo ngomelo -- Inkululeko--Democracy and freedom , Amaqhawe namaqhawekazi -- Heroes -- Heroines , Iincwadi namabali -- letters and stories , Phemba Mfundi Journal 2011
- Language: English , Xhosa
- Type: text
- Identifier: vital:12216 , http://hdl.handle.net/10353/d1013528 , Inkedama -- Ukufa , Protests -- Our roots , Protest -- Praise poems , Oomana -- Women , Umtshato -- Wedding -- Humanities , Ugawulayo -- HIV & AIDS , Indalo -- Nature , Ulawulo ngomelo -- Inkululeko--Democracy and freedom , Amaqhawe namaqhawekazi -- Heroes -- Heroines , Iincwadi namabali -- letters and stories
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- Date Issued: 2011
Knowing, acting and being: Epistemological and ontological access in a Science Extended Studies course
- Authors: Ellery, Karen
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/69471 , vital:29540 , https://hdl.handle.net/10520/EJC37737
- Description: Gross participation and throughput rates in higher education institutions in South Africa indicate an inequitable and poorly functioning system. This interpretive study argues for an approach that enhances epistemological and ontological access and examines how an intervention that includes an overt approach in dealing with the nature of science, coupled with student involvement in an independent research project in a Science Extended Studies course, can enhance such access to higher education study. Analysis of project outcomes and student critical reflections indicated access to scientific and academic Discourses was enhanced through: developing improved procedural and conceptual scientific knowledge; meaningful engagement with the language, norms and conventions of the Discourse; integrating everyday knowledge into more abstract scientific knowledge; awareness of the process of validation of scientific knowledge, of the limitations of science, and of the impact of science on society; and transforming personally by developing scientific discursive identity and a sense of belonging. In conclusion, it is argued that curriculum interventions that focus on epistemological and ontological aspects of learning could appropriately be used throughout the higher education science sector.
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- Date Issued: 2011
Learning to squander: making meaningful connections in the infinite text of world culture
- Authors: Jamal, Ashraf
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147391 , vital:38632 , https://0-hdl.handle.net.wam.seals.ac.za/10520/EJC45816
- Description: In this article on South African visual art I fix my sight on a global interhuman and aesthetic sphere in which region/nation/transnation merge to produce a cultural economy that overlaps and cannot be satisfactorily grasped according to a centre-periphery model. This eschewal of existing binary models also means a reconceptualisation of the liminal as an in-between space in a fixed divide. Currently it is not only the margin that is indeterminate, but the infinite text of the global cultural economy within which visual art plays its part.
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- Date Issued: 2011
Life history and population dynamics of invasive common carp, Cyprinus carpio, within a large turbid African impoundment
- Authors: Winker, A Henning , Weyl, Olaf L F , Booth, Anthony J , Ellender, Bruce R
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124898 , vital:35708 , https://doi.10.1071/MF11054
- Description: Common carp (Cyprinus carpio) is one of the world’s most widely introduced and established freshwater fishes (Casal 2006). The species is considered to be one of the eight most invasive freshwater fishes (Lowe et al. 2000) and worldwide, it accounts for most of the records of successful establishments and adverse ecological effects (Casal 2006; Kulhanek et al. 2011). This invasive success suggests that feral C. carpio is equipped with a set of adaptable life history attributes that allow it to successfully colonise a wide range of habitats (Koehn 2004; Zambrano et al. 2006; Britton et al. 2007). Where feral C. carpio occurs in high densities, it is often perceived as an invasive pest species (Sivakumaran et al. 2003; Brown and Walker 2004; Koehn 2004) because it can have severe impacts on habitat heterogeneity and biodiversity by increasing water turbidity through its bottom feeding behaviour, increasing nutrient availability, decreasing benthic and macrophyte density and diversity, altering zooplankton assemblages and decreasing endemic fish abundance (Zambrano et al. 2001; Khan 2003; Kulhanek et al. 2011). Within south-east Australia, for example, C. carpio comprises the largest proportion of the ichthyobiomass in the continent’s largest river system – the Murray–Darling Basin (Gehrke et al. 1995). As a consequence, serious concerns about its threat to endemic freshwater species (Koehn 2004) have prompted several of the most recent investigations into its life history (e.g. Sivakumaran et al. 2003; Smith and Walker 2004; Brown et al. 2005). Other potential threats posed also include competition with indigenous species and the spread of diseases and parasites (Dudgeon et al. 2006). In South Africa, for example, Asian tapeworm Bothriocephalus acheilognathi is now widely distributed in seven river systems and has infected eight novel cyprinid hosts due to the translocation of infected by C. carpio from a centralized aquaculture facility (Stadtlander et al. 2011).
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- Date Issued: 2011
LTSP DNS round robin clusters: green technology access enablers for telecommunication services in marginalised communities
- Authors: Siebörger, Ingrid , Terzoli, Alfredo , Hodgkinson-Williams, Cheryl
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/428437 , vital:72511 , https://d1wqtxts1xzle7.cloudfront.net/75984640/177-libre.pdf?1639074275=andresponse-content-disposi-tion=inline%3B+filename%3DLTSP_DNS_Round_Robin_Clusters_Green_Tech.pdfandExpires=1714912779andSignature=Gmd52OTCvGmiKhiFiQH~rrfp6lSPbp7glndLPn7V4Jy5yt7lU-eToE4IPxr7lDQQOdUW348nkXIMgYHnXkWjWl7nYBM7hlluxJGd15oKbpifvTofHVVEB-kOLbz0caOrAodnS~eMHdebRQOumKSAHPGQkqem756vbw0KV7bhmFQ0TUN-vsVeBoH5ftfg7s355Oh9EZCQhZu~~P0AWzlSRnMTH~6vpj3EKvp7P4gy55oISZ~207VFFFZidb90aoP7JWehRYjRqn3Tk19A6nwm4o9U-wc9Dz1MrCy-YfbqOxdNulQh4bti2WI7DA6C3Q8TMCbtqnZskXQYsIzfEianS~gw__andKey-Pair-Id=APKAJLOHF5GGSLRBV4ZA
- Description: Rural development is seen as a priority in South Africa; information and knowledge are key strategic resources for social and economic develop-ment. Information Communication Technologies (ICTs) are seen as im-portant tools in rural development, assisting in enabling change through economic development. In rural areas where ICT infrastructure is being expanded and deployed there is a need to provide appropriate technolo-gies that support sustainability and meet the needs of the local communi-ty. In this paper we argue that the use of Linux Terminal Server Project (LTSP) cluster servers are appropriate technologies for use in computer laboratory environments for relatively inexpensive access to technologies by schools and local communities in rural areas. Typically LTSP clusters are deployed when there is a need to support 100s or 1000s of comput-ers, however, we argue that by reusing recycled (older) desktop or server computers as cluster servers could lower the entry level costs of LTSP computing while maximising the use of available resources. The paper details the configuration of a Domain Name System (DNS) round robin cluster solution together with initial testing and results. It is suggested that LTSP cluster solutions, and the DNS round robin implementation, show promise for use in providing access technologies to rural communities and schools.
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- Date Issued: 2011
Microelectrochemical patterning of gold surfaces using 4-azidobenzenediazonium and scanning electrochemical microscopy
- Authors: Coates, Megan , Cabet, Eva , Griveau, Sophie , Nyokong, Tebello , Bedioui, Fethi
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247926 , vital:51630 , xlink:href="https://doi.org/10.1016/j.elecom.2010.11.037"
- Description: This work describes for the first time the possibility of performing local micro electrochemical grafting of a gold substrate by 4-azidobenzenediazonium by SECM in a single and simple one step without complications from adsorption. The electrografted spots of diazonium were performed by positioning a Pt tip at a given distance above the gold substrate and the SECM was used in a three-electrode configuration (the Pt tip serving as the microanode) in acetonitrile containing 5 mM 4-azidobenzenediazonium and 0.1 M Bu4NBF4 during 10 ms. The dimensions of the derivatized areas of the substrates were finely tuned by using different experimental conditions (tip distance above the substrate, tip diameter, presence or absence of supporting electrolyte). The use of the azido-derivated diazonium molecule and these preliminary results open the gate to important applications and developments devoted to the local micro functionalization of electrodes by thin layers that allow the implementation of the emerging and attractive interfacial click reaction.
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- Date Issued: 2011
MMORPG: Towards a Sustainable Livelihood Model for Africa and Beyond
- Authors: Mostert, Andre , Kaschula, Russell H
- Date: 2011
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/175212 , vital:42553 , ISBN ViNOrg 2011 , https://link.springer.com/chapter/10.1007/978-3-642-31800-9_4
- Description: The burgeoning worlds of massively multiplayer online role-playing games (MMORPG) coupled with increasing access to the internet is opening a new paradigmatic window for a number of disciplines. Many of these have been slow to take up the challenges associated with this emergent framework, due, in no small measure, to the perception that work and play are mutually exclusive. The dominance of this dichotomy contributed to the slow uptake of the potential for these virtual worlds to be harnessed in the fields of education and employment. This reticence was due in no small measure to the technophobia that tends to characterise the adoption of new technologies within fields that have customarily eschewed an embrace.
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- Date Issued: 2011
National case study : teacher professional development with an education for sustainable development focus in South Africa: development of a network, curriculum framework and resources for teacher education
- Authors: Lotz-Sisitka, Heila
- Date: 2011
- Subjects: Teachers -- Training of , Career development , Sustainable development -- South Africa
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/10962/59646 , vital:27634 , https://www.ajol.info/index.php/sajee/article/view/122242
- Description: This national case study reports on the development of a national network, curriculum framework and resources for teacher education, with specific focus on the inclusion of environment and sustainability, also known as education for sustainable development (ESD) in the South African teacher education system. It reviews and reports on the history of environment and sustainability education in teacher education, and from this, the national case study begins to conceptualise a new approach to environment and sustainability teacher education within a new curriculum policy environment, and a new teacher education and development policy environment. Action research case study methodology is used to document the first phase of the emergence of this network, and this report covers Phase 1 of the initiative, which covers formation of the network, review of previous practices, three conceptual development pilot studies undertaken in both in-service and pre-service teacher education environments and a piloting of a ‘Train the Trainers’ or ‘Educate the Teacher Educators’ programme, which complements and extends the actual teacher education and development (TED) programme under development. The study highlights critical insights of relevance to the shift to a content referenced curriculum in South Africa, and shows how the ‘knowledge mix’ which forms the foundation of the new Teacher Education Qualifications Framework can be engaged. It also highlights some features of the changing knowledge environment, and what dominant knowledge practices are in environment and sustainability-related teaching and teacher education practices, opening these up for further scrutiny. It raises concerns that dominant knowledge work, while integrating a range of forms of knowledge (as is expected of the teacher education system under the new policy), tends to be limited by content on problems and issues for raising awareness, and fails to develop deeper conceptual depth and understanding of environment and sustainability, as issues based knowledge dominates. Similarly, it fails to support social innovation as a response to environment and sustainability concerns, as awareness raising dominates in dominant knowledge work. The study provides a revised conceptual framework for the Teacher Development Network (TEDN) programme, with guidance on key elements necessary to take the programme forward in Phase 2.
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- Date Issued: 2011