Exploring targeted metagenomics and untargeted metabolomics for characterising aquaponics bacterial ecology and phytochemistry
- Authors: Abraham, Benjamin Melakail
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192453 , vital:45227
- Description: Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Abraham, Benjamin Melakail
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192453 , vital:45227
- Description: Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-10-29
Cellphones and whistles: Exploring the communicative ecology and sociality of the Enkanini informal settlement in Makhanda
- Authors: Baloyi, Karabo
- Date: 2021-10-29
- Subjects: Communication models , Cell phones Social aspects South Africa Makhanda , Cell phones Economic aspects South Africa Makhanda , Squatter settlements South Africa Makhanda , South Africa Social conditions 1994- , South Africa Economic conditions 1991- , South Africa Social life and customs , Communication Economic aspects South Africa Makhanda , Whistles South Africa Makhanda , Decolonization South Africa Makhanda , Communicative ecology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/191046 , vital:45053
- Description: This thesis explores the communicative ecology in the Enkanini informal settlement in Makhanda, and in particular their use of mobile phones and whistles to build a sense of community. It makes the case for word-of-mouth as an integral part of the communicative ecology despite not being a technological device. It then examines the sociality that arises from the use of these devices, and how coloniality impacts on the participants’ everyday experiences. The research was conducted through telephonic in-depth interviews with participants. To corroborate some of the content drawn from interviews, I used Grocott’s Mail, Makhanda’s only independent newspaper as an archival source, as well as some of the participants’ Facebook profiles. This research argues that as a consequence of coloniality, Enkanini’s residents suffer socio-economic challenges, and thus are unable to use digital technologies as much as they might like to, to communicate with their neighbours. As a consequence, word-of-mouth is their main form of communication with one another. Whistles are the ‘low-tech’ device used for community-wide communication to alert residents of an emergency, or about a meeting or protest. My findings contest generalised claims of society moving towards a network sociality, where individuality and project-based communication is valued over more communal forms of living. They also demonstrate the ways in which coloniality shapes almost every aspect of marginalised people’s lives, making word of mouth the most significant form of communication, notwithstanding the apparent availability of digital technology. It also shows how a marginalised group uses the resources it has to pressure local government officials to provide them with the basis infrastructure they need for survival. , Thesis (MA) -- Faculty of Humanities, Journalism and Media Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Baloyi, Karabo
- Date: 2021-10-29
- Subjects: Communication models , Cell phones Social aspects South Africa Makhanda , Cell phones Economic aspects South Africa Makhanda , Squatter settlements South Africa Makhanda , South Africa Social conditions 1994- , South Africa Economic conditions 1991- , South Africa Social life and customs , Communication Economic aspects South Africa Makhanda , Whistles South Africa Makhanda , Decolonization South Africa Makhanda , Communicative ecology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/191046 , vital:45053
- Description: This thesis explores the communicative ecology in the Enkanini informal settlement in Makhanda, and in particular their use of mobile phones and whistles to build a sense of community. It makes the case for word-of-mouth as an integral part of the communicative ecology despite not being a technological device. It then examines the sociality that arises from the use of these devices, and how coloniality impacts on the participants’ everyday experiences. The research was conducted through telephonic in-depth interviews with participants. To corroborate some of the content drawn from interviews, I used Grocott’s Mail, Makhanda’s only independent newspaper as an archival source, as well as some of the participants’ Facebook profiles. This research argues that as a consequence of coloniality, Enkanini’s residents suffer socio-economic challenges, and thus are unable to use digital technologies as much as they might like to, to communicate with their neighbours. As a consequence, word-of-mouth is their main form of communication with one another. Whistles are the ‘low-tech’ device used for community-wide communication to alert residents of an emergency, or about a meeting or protest. My findings contest generalised claims of society moving towards a network sociality, where individuality and project-based communication is valued over more communal forms of living. They also demonstrate the ways in which coloniality shapes almost every aspect of marginalised people’s lives, making word of mouth the most significant form of communication, notwithstanding the apparent availability of digital technology. It also shows how a marginalised group uses the resources it has to pressure local government officials to provide them with the basis infrastructure they need for survival. , Thesis (MA) -- Faculty of Humanities, Journalism and Media Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
Modification of Gelatin-Methacrylate, Hyaluronic-Methacrylate and Poly(ethylene) glycol Diacrylate hydrogel bioinks towards the additive manufacturing of articular cartilage
- Authors: Barwick, Matthew William
- Date: 2021-10
- Subjects: Cartilage Diseases , Cartilage Regeneration , Articular cartilage Diseases , Chondrogenesis , Stem cells , Scanning electron microscopy , Fourier transform infrared spectroscopy , Three-dimensional printing , Gelatin-Methacrylate , Hyaluronic-Methacrylate , Poly(ethylene) glycolDiacrylate , Hydrogel bioinks , Real-Time Quantitative Cell Analysis (RTCA) , Bioprinting
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/191181 , vital:45068
- Description: Cartilage degradation is most commonly associated with Rheumatoid arthritis and Osteoarthritis, affecting millions of people worldwide. Joint transplants commonly use titanium alloys, which have a shelf life of between 10-15 years. Although the titanium transplant restores partial mobility, side effects such as inflammation, swelling, faulty implants, and metal poisoning in some cases resulting from the transplant. The use of additive manufacturing of articular cartilage sheds new, innovative prospects for joint replacements. This study sets out to formulate and characterize five different hydrogel types towards the additive manufacturing of articular cartilage. Chondrogenic and Adipogenic differentiation was carried out on two separate adipose-mesenchymal stem cell lines A270620-01A, and A311019-02T and validation and efficiency of the differentiation and chondrogenic gene expression was carried out using Alcian Blue stain, Oil Red O stain and Quantitative Reverse Transcription PCR (RT-qPCR). Hydrogel formulation and characterisation of 10 % Gelatin-methacryloyl (GelMA), 10 % Poly (ethylene) glycol diacrylate (PEGDA), 5 % GelMA/5 % PEGDA, 10 % GelMA/0.5 % Hyaluronic Acid Methacrylate (HAMA) and 10 % PEGDA/0.5 % HAMA was carried out through swelling and degradation ratios, surface area and porosity characterisation using Scanning Electron Microscopy (SEM). Hydrogel component and spectroscopic analysis were carried using Real-Time Quantitative Cell Analysis (RTCA) and Fourier-transform Infrared Spectroscopy (FTIR) analysis for each formulated hydrogel's chemical characterisation. Three-dimensional printing (3D) of 10 % PEGDA/0.5 % HAMA and 5 % GelMA/5 % PEGDA was performed using the Zortrax INKSPIRE Resin Ultra-Violet (UV) LCD Desktop 3D Printer. Hydrogel sterility and cell viability were carried out for each hydrogel type using fluorescence microscopy. Both A270620-01A and A311019-02T cell lines showed adipogenic and chondrogenic differentiation ability, with A311019-02T cell line showing greater chondrogenic differentiation of Alcian blue staining. The A270620-01A cell line resulted in a greater collagen gene expression based on the RT-qPCR results. The hydrogel 10 % GelMA showed the greatest swelling ratio of 1260 % in DPBS and 1192 % in DMEM. A significant difference between hydrogel swelling and swelling with Dulbecco's Phosphate Buffered Saline (DPBS) and Dulbecco’s Modified Eagle Medium (DMEM) was observed. The 10 % PEGDA hydrogel had the greatest degradation ratio of 59 % mass remaining, where the 10 % GelMA/0.5 % HAMA showed the least amount of degradation with a mass remaining at 91 %. The 10 % GelMA showed the greatest porosity will the largest pore size of 14 μm in diameter. Hydrogel component and spectroscopic analysis showed no cytotoxic effects for the visible light photoinitiator used to polymerize the hydrogel and no cytotoxic effects for the concentrations used in chondrogenic differentiation. The FTIR analysis showed partial gelatin and hyaluronic acid modification with methacrylic anhydride; however, the distinction between the hybrid hydrogels and single polymer hydrogels could not be made effectively. UV and ethanol washing showed to completely sterilise the hydrogel disks from any contaminants, making them suitable for tissue culture. The cell viability analysis showed the 10 % GelMA/HAMA having the highest cell viability of 77.3 % using 5000 cells/disk and 89.64 % viability using 50 000 cells/disk over a 7-day incubation period. Overall, the combination of two polymers, GelMA and HAMA, has good potential as a 3D hydrogel scaffold towards additive manufacturing of articular cartilage. , Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2021
- Full Text:
- Date Issued: 2021-10
- Authors: Barwick, Matthew William
- Date: 2021-10
- Subjects: Cartilage Diseases , Cartilage Regeneration , Articular cartilage Diseases , Chondrogenesis , Stem cells , Scanning electron microscopy , Fourier transform infrared spectroscopy , Three-dimensional printing , Gelatin-Methacrylate , Hyaluronic-Methacrylate , Poly(ethylene) glycolDiacrylate , Hydrogel bioinks , Real-Time Quantitative Cell Analysis (RTCA) , Bioprinting
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/191181 , vital:45068
- Description: Cartilage degradation is most commonly associated with Rheumatoid arthritis and Osteoarthritis, affecting millions of people worldwide. Joint transplants commonly use titanium alloys, which have a shelf life of between 10-15 years. Although the titanium transplant restores partial mobility, side effects such as inflammation, swelling, faulty implants, and metal poisoning in some cases resulting from the transplant. The use of additive manufacturing of articular cartilage sheds new, innovative prospects for joint replacements. This study sets out to formulate and characterize five different hydrogel types towards the additive manufacturing of articular cartilage. Chondrogenic and Adipogenic differentiation was carried out on two separate adipose-mesenchymal stem cell lines A270620-01A, and A311019-02T and validation and efficiency of the differentiation and chondrogenic gene expression was carried out using Alcian Blue stain, Oil Red O stain and Quantitative Reverse Transcription PCR (RT-qPCR). Hydrogel formulation and characterisation of 10 % Gelatin-methacryloyl (GelMA), 10 % Poly (ethylene) glycol diacrylate (PEGDA), 5 % GelMA/5 % PEGDA, 10 % GelMA/0.5 % Hyaluronic Acid Methacrylate (HAMA) and 10 % PEGDA/0.5 % HAMA was carried out through swelling and degradation ratios, surface area and porosity characterisation using Scanning Electron Microscopy (SEM). Hydrogel component and spectroscopic analysis were carried using Real-Time Quantitative Cell Analysis (RTCA) and Fourier-transform Infrared Spectroscopy (FTIR) analysis for each formulated hydrogel's chemical characterisation. Three-dimensional printing (3D) of 10 % PEGDA/0.5 % HAMA and 5 % GelMA/5 % PEGDA was performed using the Zortrax INKSPIRE Resin Ultra-Violet (UV) LCD Desktop 3D Printer. Hydrogel sterility and cell viability were carried out for each hydrogel type using fluorescence microscopy. Both A270620-01A and A311019-02T cell lines showed adipogenic and chondrogenic differentiation ability, with A311019-02T cell line showing greater chondrogenic differentiation of Alcian blue staining. The A270620-01A cell line resulted in a greater collagen gene expression based on the RT-qPCR results. The hydrogel 10 % GelMA showed the greatest swelling ratio of 1260 % in DPBS and 1192 % in DMEM. A significant difference between hydrogel swelling and swelling with Dulbecco's Phosphate Buffered Saline (DPBS) and Dulbecco’s Modified Eagle Medium (DMEM) was observed. The 10 % PEGDA hydrogel had the greatest degradation ratio of 59 % mass remaining, where the 10 % GelMA/0.5 % HAMA showed the least amount of degradation with a mass remaining at 91 %. The 10 % GelMA showed the greatest porosity will the largest pore size of 14 μm in diameter. Hydrogel component and spectroscopic analysis showed no cytotoxic effects for the visible light photoinitiator used to polymerize the hydrogel and no cytotoxic effects for the concentrations used in chondrogenic differentiation. The FTIR analysis showed partial gelatin and hyaluronic acid modification with methacrylic anhydride; however, the distinction between the hybrid hydrogels and single polymer hydrogels could not be made effectively. UV and ethanol washing showed to completely sterilise the hydrogel disks from any contaminants, making them suitable for tissue culture. The cell viability analysis showed the 10 % GelMA/HAMA having the highest cell viability of 77.3 % using 5000 cells/disk and 89.64 % viability using 50 000 cells/disk over a 7-day incubation period. Overall, the combination of two polymers, GelMA and HAMA, has good potential as a 3D hydrogel scaffold towards additive manufacturing of articular cartilage. , Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2021
- Full Text:
- Date Issued: 2021-10
Self-inquiry: Comparing Plato and Patanjali
- Authors: Coughlan, Daniel Michael
- Date: 2021-10
- Subjects: Plato , Patañjali , Self , Identity (Philosophical concept) , Comparison (Philosophy) , Justification (Theory of knowledge)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190066 , vital:44960
- Description: At its most effective my research hopes to re-affirm the central value and importance of self-inquiry. That is, I hope to echo the familiar call of the wise to know thyself. Of the many mouths and temple walls that have lent authority to this precept there is perhaps no mouth more important than one’s own. To know thyself is the task and responsibility of the individual. In order to arrive at the point where I can re-affirm its value I explore the nature of self-inquiry with the help of Plato, Patanjali and a comparison between them. I propose two general senses in which we might understand self-inquiry and seek to bring out the core problems faced by each. We find an account of these two senses and the relationship between them in both Plato and Patanjali, so too, though less obviously, in the comparison between them. The comparison provides the opportunity for reflecting on the ground that it moves from and depends on, the common ground we assume between the two compared philosophers/ies. I contend that this ground is ultimately the comparer, one’s self. The consequence is that the comparative project and the project of self-inquiry both meet and are mutually beneficial. The three together; Plato, Patanjali, and the comparison between them help us account for nature of self-inquiry in helping us to better understand the relationship between the two senses in which we can come to understand and think about it. In the first sense, self-inquiry is cast as the examination of one’s life. In the second sense, we are invited to consider the possibility of an unmediated knowing of the examiner, an unmediated self-knowing. With a better understanding of what self-inquiry is I stand to conclude by re-affirming its value. , Thesis (MPhil) -- Faculty of Humanities, Philosophy, 2021
- Full Text:
- Date Issued: 2021-10
- Authors: Coughlan, Daniel Michael
- Date: 2021-10
- Subjects: Plato , Patañjali , Self , Identity (Philosophical concept) , Comparison (Philosophy) , Justification (Theory of knowledge)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190066 , vital:44960
- Description: At its most effective my research hopes to re-affirm the central value and importance of self-inquiry. That is, I hope to echo the familiar call of the wise to know thyself. Of the many mouths and temple walls that have lent authority to this precept there is perhaps no mouth more important than one’s own. To know thyself is the task and responsibility of the individual. In order to arrive at the point where I can re-affirm its value I explore the nature of self-inquiry with the help of Plato, Patanjali and a comparison between them. I propose two general senses in which we might understand self-inquiry and seek to bring out the core problems faced by each. We find an account of these two senses and the relationship between them in both Plato and Patanjali, so too, though less obviously, in the comparison between them. The comparison provides the opportunity for reflecting on the ground that it moves from and depends on, the common ground we assume between the two compared philosophers/ies. I contend that this ground is ultimately the comparer, one’s self. The consequence is that the comparative project and the project of self-inquiry both meet and are mutually beneficial. The three together; Plato, Patanjali, and the comparison between them help us account for nature of self-inquiry in helping us to better understand the relationship between the two senses in which we can come to understand and think about it. In the first sense, self-inquiry is cast as the examination of one’s life. In the second sense, we are invited to consider the possibility of an unmediated knowing of the examiner, an unmediated self-knowing. With a better understanding of what self-inquiry is I stand to conclude by re-affirming its value. , Thesis (MPhil) -- Faculty of Humanities, Philosophy, 2021
- Full Text:
- Date Issued: 2021-10
Factors contributing to unsafe practices in Eskom power division projects
- Authors: Dingilizwe, Nondumiso
- Date: 2021-03
- Subjects: Power-plants
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59226 , vital:60314
- Description: Health and safety is accepted as an integral element of the built environment. As construction within the electricity and power supply industry is inevitable, alongside other regulatory systems aimed at ensuring sustainable power supply, health and safety measures, policies, training, management, and incidences become important indicators for the delivery of power supply. This research study explores the health and safety management challenges that are experienced by the construction division of Eskom, South Africa’s national power utility with its head offices in Johannesburg, South Africa. The research explores and identifies factors that affect workers’ on-site behaviour regarding the compliance and adherence to health and safety statutory practices. Using a qualitative research method, and thematic data analysis, the research findings draw on salient emerging themes that allude to the inadequate and insufficient documentation of Eskom procedures, and the failure to make use of recorded past incidents in establishing improved pro-active health and safety management practice and management thereof, are but some of the illuminated factors that emerge from the study findings. For a power utility of its scale and the volume of electricity generation, transmission, and distribution, the compliance to internationally recognised health and safety standards within an appropriate legal framework, are factors that may hinder the successful implementation of its core function. Notwithstanding the fact that the electricity sector of industry, in terms of overall current health, safety and performance, is generally considered to be a lower risk than other industries within the South African economy. Yet this study, in taking cognisance of all four sectors of the energy and power value chain (generation, transmission, distribution and retail), attempts to address the unanswered questions if why and how Eskom, despite its health and safety policies and general compliance to statutory workplace health and safety framework, continues to experience a high level of workplace fatalities in the delivery of its projects. Against a backdrop of reported and documented incidences of time, this research found that the usage of reports to benchmark and re-calibrate policy and preventative procedure is carried out periodically, but in an unstructured manner. The risk this presents is evident in the potential failure to identify proper risk analysis, appropriate health and safety vi performance indicators, and a slow migration to the new ISO 45001 quality standard. Study findings also suggest a lack of training programmes for contractors and employees within Eskom construction projects, as a primary contributing hindrance factor to attaining an improved health and safety management system. Finally, the study also considered new hazards and risks that have, and may still, arise from the uptake and expansion of new technologies, cleaner energy, as well as future trends that would collectively influence health and safety standards along the electricity value chain. The research findings suggest for a more focused goal-setting and the building of competencies to recognise and mitigate risks, especially new risks, and to engage more participatory approaches to setting standards that can be effectively managed and which can contribute to injury reduction through behavioural change. What remains to be explored, will be the changing nature of doing business as the year 2020 witnesses a new confounding pandemic, the Coronavirus (covid-19). Its impact on health and safety in the workplace, and on the entire construction value chain, cost of construction, project management and timeframes, is yet to be determined and factored into the business processes of a large scale public entity such as Eskom. , Thesis (MA) -- Faculty of Engineering, the Built Environment, and Technology, 2021
- Full Text:
- Date Issued: 2021-03
- Authors: Dingilizwe, Nondumiso
- Date: 2021-03
- Subjects: Power-plants
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59226 , vital:60314
- Description: Health and safety is accepted as an integral element of the built environment. As construction within the electricity and power supply industry is inevitable, alongside other regulatory systems aimed at ensuring sustainable power supply, health and safety measures, policies, training, management, and incidences become important indicators for the delivery of power supply. This research study explores the health and safety management challenges that are experienced by the construction division of Eskom, South Africa’s national power utility with its head offices in Johannesburg, South Africa. The research explores and identifies factors that affect workers’ on-site behaviour regarding the compliance and adherence to health and safety statutory practices. Using a qualitative research method, and thematic data analysis, the research findings draw on salient emerging themes that allude to the inadequate and insufficient documentation of Eskom procedures, and the failure to make use of recorded past incidents in establishing improved pro-active health and safety management practice and management thereof, are but some of the illuminated factors that emerge from the study findings. For a power utility of its scale and the volume of electricity generation, transmission, and distribution, the compliance to internationally recognised health and safety standards within an appropriate legal framework, are factors that may hinder the successful implementation of its core function. Notwithstanding the fact that the electricity sector of industry, in terms of overall current health, safety and performance, is generally considered to be a lower risk than other industries within the South African economy. Yet this study, in taking cognisance of all four sectors of the energy and power value chain (generation, transmission, distribution and retail), attempts to address the unanswered questions if why and how Eskom, despite its health and safety policies and general compliance to statutory workplace health and safety framework, continues to experience a high level of workplace fatalities in the delivery of its projects. Against a backdrop of reported and documented incidences of time, this research found that the usage of reports to benchmark and re-calibrate policy and preventative procedure is carried out periodically, but in an unstructured manner. The risk this presents is evident in the potential failure to identify proper risk analysis, appropriate health and safety vi performance indicators, and a slow migration to the new ISO 45001 quality standard. Study findings also suggest a lack of training programmes for contractors and employees within Eskom construction projects, as a primary contributing hindrance factor to attaining an improved health and safety management system. Finally, the study also considered new hazards and risks that have, and may still, arise from the uptake and expansion of new technologies, cleaner energy, as well as future trends that would collectively influence health and safety standards along the electricity value chain. The research findings suggest for a more focused goal-setting and the building of competencies to recognise and mitigate risks, especially new risks, and to engage more participatory approaches to setting standards that can be effectively managed and which can contribute to injury reduction through behavioural change. What remains to be explored, will be the changing nature of doing business as the year 2020 witnesses a new confounding pandemic, the Coronavirus (covid-19). Its impact on health and safety in the workplace, and on the entire construction value chain, cost of construction, project management and timeframes, is yet to be determined and factored into the business processes of a large scale public entity such as Eskom. , Thesis (MA) -- Faculty of Engineering, the Built Environment, and Technology, 2021
- Full Text:
- Date Issued: 2021-03
A modelling approach to the analysis of complex survey data
- Authors: Dlangamandla, Olwethu
- Date: 2021-10-29
- Subjects: Sampling (Statistics) , Linear models (Statistics) , Multilevel models (Statistics) , Logistic regression analysis , Complex survey data
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192955 , vital:45284
- Description: Surveys are an essential tool for collecting data and most surveys use complex sampling designs to collect the data. Complex sampling designs are used mainly to enhance representativeness in the sample by accounting for the underlying structure of the population. This often results in data that are non-independent and clustered. Ignoring complex design features such as clustering, stratification, multistage and unequal probability sampling may result in inaccurate and incorrect inference. An overview of, and difference between, design-based and model-based approaches to inference for complex survey data has been discussed. This study adopts a model-based approach. The objective of this study is to discuss and describe the modelling approach in analysing complex survey data. This is specifically done by introducing the principle inference methods under which data from complex surveys may be analysed. In particular, discussions on the theory and methods of model fitting for the analysis of complex survey data are presented. We begin by discussing unique features of complex survey data and explore appropriate methods of analysis that account for the complexity inherent in the survey data. We also explore the widely applied logistic regression modelling of binary data in a complex sample survey context. In particular, four forms of logistic regression models are fitted. These models are generalized linear models, multilevel models, mixed effects models and generalized linear mixed models. Simulated complex survey data are used to illustrate the methods and models. Various R packages are used for the analysis. The results presented and discussed in this thesis indicate that a logistic mixed model with first and second level predictors has a better fit compared to a logistic mixed model with first level predictors. In addition, a logistic multilevel model with first and second level predictors and nested random effects provides a better fit to the data compared to other logistic multilevel fitted models. Similar results were obtained from fitting a generalized logistic mixed model with first and second level predictor variables and a generalized linear mixed model with first and second level predictors and nested random effects. , Thesis (MSC) -- Faculty of Science, Statistics, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Dlangamandla, Olwethu
- Date: 2021-10-29
- Subjects: Sampling (Statistics) , Linear models (Statistics) , Multilevel models (Statistics) , Logistic regression analysis , Complex survey data
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192955 , vital:45284
- Description: Surveys are an essential tool for collecting data and most surveys use complex sampling designs to collect the data. Complex sampling designs are used mainly to enhance representativeness in the sample by accounting for the underlying structure of the population. This often results in data that are non-independent and clustered. Ignoring complex design features such as clustering, stratification, multistage and unequal probability sampling may result in inaccurate and incorrect inference. An overview of, and difference between, design-based and model-based approaches to inference for complex survey data has been discussed. This study adopts a model-based approach. The objective of this study is to discuss and describe the modelling approach in analysing complex survey data. This is specifically done by introducing the principle inference methods under which data from complex surveys may be analysed. In particular, discussions on the theory and methods of model fitting for the analysis of complex survey data are presented. We begin by discussing unique features of complex survey data and explore appropriate methods of analysis that account for the complexity inherent in the survey data. We also explore the widely applied logistic regression modelling of binary data in a complex sample survey context. In particular, four forms of logistic regression models are fitted. These models are generalized linear models, multilevel models, mixed effects models and generalized linear mixed models. Simulated complex survey data are used to illustrate the methods and models. Various R packages are used for the analysis. The results presented and discussed in this thesis indicate that a logistic mixed model with first and second level predictors has a better fit compared to a logistic mixed model with first level predictors. In addition, a logistic multilevel model with first and second level predictors and nested random effects provides a better fit to the data compared to other logistic multilevel fitted models. Similar results were obtained from fitting a generalized logistic mixed model with first and second level predictor variables and a generalized linear mixed model with first and second level predictors and nested random effects. , Thesis (MSC) -- Faculty of Science, Statistics, 2021
- Full Text:
- Date Issued: 2021-10-29
An evolutionary study of legless skinks’ (Acontias Cuvier, 1817) head and vertebrae morphology
- Authors: Evlambiou, Anthony Andreas
- Date: 2021-10
- Subjects: Skinks South Africa , Acontias South Africa , Typhlosaurus South Africa , Acontias Morphology , Acontias Phylogeny , Acontias Evolution , Vertebrae , Skull Growth , Evolutionary developmental biology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190690 , vital:45018
- Description: Environmental factors and/or processes can produce differences in general shape between individuals or particular parts of individuals. Examples of these biological processes may include ontogenetic development, adaptation to local geographic factors, or long-term evolutionary diversification. An organism is not likely to be able to optimise a single structure for multiple purposes and so trade-offs are likely to occur. An example of such a structure is the cranium, as it can be used for multiple activities such as defensive and sexual behaviour, locomotion, prey capture, and ingestion. Morphological characteristics have historically been used in the description of species. Genetic analyses have gained popularity as species delineation techniques and have been particularly useful in identifying cryptic species, especially among morphological conserved species like legless skinks of the subfamily Acontinae (e.g. Acontias Cuvier, 1817 and Typhlosaurus Weigmann, 1834). However, completely doing away with morphological techniques during species descriptions is not the best option. Therefore, novel methods to identify species, especially those with similar body plans, are needed. In this dissertation, we explore the links between head shape and vertebral number to environmental pressures to determine whether the evolutionary process is driven by environmental pressures (soil or biome) or is retained through ancestry. A novel species/clade delineation linked to vertebral number is also investigated. Head shape was expected to have a close link to the environment and the number of vertebrae was expected to have a closer link to ancestry. The first chapter investigates the drivers behind Acontias head shape evolution using geometric morphometric techniques. We found that environmental pressures did affect the evolution of head shape especially in the “soil” and “biome” categories but further investigation is advised. The second chapter explores the viability of using vertebral counts as a novel method for species and/or clade delineation in Acontias and to determine whether vertebral number can be linked to the environment. Delineating species based on vertebral count is likely not an option, however, delineating clades proved to show promising results. A link between vertebral count and environment was found in Acontias with larger bodied species occurring in different environments to smaller body species. In conclusion, the genus Acontias is difficult to delineate morphologically. Genetic sequence analyses can indicate differences and delineate the species. Even though there were differences in morphology based on environmental factors, it is not sufficient to delineate this subfamily alone. Further research is advised and this dissertation provides a good basis to work with. , Thesis (MSc) -- Faculty of Science, Zoology and Entomology, 2021
- Full Text:
- Date Issued: 2021-10
- Authors: Evlambiou, Anthony Andreas
- Date: 2021-10
- Subjects: Skinks South Africa , Acontias South Africa , Typhlosaurus South Africa , Acontias Morphology , Acontias Phylogeny , Acontias Evolution , Vertebrae , Skull Growth , Evolutionary developmental biology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190690 , vital:45018
- Description: Environmental factors and/or processes can produce differences in general shape between individuals or particular parts of individuals. Examples of these biological processes may include ontogenetic development, adaptation to local geographic factors, or long-term evolutionary diversification. An organism is not likely to be able to optimise a single structure for multiple purposes and so trade-offs are likely to occur. An example of such a structure is the cranium, as it can be used for multiple activities such as defensive and sexual behaviour, locomotion, prey capture, and ingestion. Morphological characteristics have historically been used in the description of species. Genetic analyses have gained popularity as species delineation techniques and have been particularly useful in identifying cryptic species, especially among morphological conserved species like legless skinks of the subfamily Acontinae (e.g. Acontias Cuvier, 1817 and Typhlosaurus Weigmann, 1834). However, completely doing away with morphological techniques during species descriptions is not the best option. Therefore, novel methods to identify species, especially those with similar body plans, are needed. In this dissertation, we explore the links between head shape and vertebral number to environmental pressures to determine whether the evolutionary process is driven by environmental pressures (soil or biome) or is retained through ancestry. A novel species/clade delineation linked to vertebral number is also investigated. Head shape was expected to have a close link to the environment and the number of vertebrae was expected to have a closer link to ancestry. The first chapter investigates the drivers behind Acontias head shape evolution using geometric morphometric techniques. We found that environmental pressures did affect the evolution of head shape especially in the “soil” and “biome” categories but further investigation is advised. The second chapter explores the viability of using vertebral counts as a novel method for species and/or clade delineation in Acontias and to determine whether vertebral number can be linked to the environment. Delineating species based on vertebral count is likely not an option, however, delineating clades proved to show promising results. A link between vertebral count and environment was found in Acontias with larger bodied species occurring in different environments to smaller body species. In conclusion, the genus Acontias is difficult to delineate morphologically. Genetic sequence analyses can indicate differences and delineate the species. Even though there were differences in morphology based on environmental factors, it is not sufficient to delineate this subfamily alone. Further research is advised and this dissertation provides a good basis to work with. , Thesis (MSc) -- Faculty of Science, Zoology and Entomology, 2021
- Full Text:
- Date Issued: 2021-10
An analysis of the medicines regulatory environment in sub-Saharan Africa and the African Medicines Regulatory Harmonization Initiative
- Authors: Feka, Cedric Nyahchong
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192408 , vital:45223
- Description: Thesis (MSc (Pharm)) -- Faculty of Pharmacy, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Feka, Cedric Nyahchong
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192408 , vital:45223
- Description: Thesis (MSc (Pharm)) -- Faculty of Pharmacy, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-10-29
Production performance, socioeconomic benefits, and agricultural extension services support of scavenging chicken farmers in Raymond Mhlaba Local Municipality, Eastern Cape Province
- Fentele, Ziphozethu https://orcid.org/ 0000-0001-7939-2964
- Authors: Fentele, Ziphozethu https://orcid.org/ 0000-0001-7939-2964
- Date: 2021-03
- Subjects: Broilers (Chickens) , Poultry -- Breeding
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/21490 , vital:48751
- Description: Scavenging chicken production plays a significant role in the lives of rural farmers as it ensures food security by providing eggs and meat to rural farmers almost in all developing nations. Rural farmers not only consume scavenging chickens, they also sell live chickens to customers to generate immediate income and are able to acquire other products using the money from the sales. The purpose of this study was to investigate production performance, socioeconomic benefits, and agricultural extension services support for scavenging chicken producers. The study was carried out in eight villages in Raymond Mhlaba Local Municipality in the Eastern Cape Province of South Africa. This study employed the multistage sampling technique for data collection from respondents between October and November 2018. The study used descriptive statistics, frequencies, percentages and multiple linear regression models to analyse quantitative data that was collected from a survey of 161 rural farmers that rear scavenging chickens. The results reveal that the majority (68.3percent) of the respondents in Raymond Mhlaba Local Municipality were women, while 52percent were married. Forty-eight percent of the respondents had attained high school education. The majority (53.4percent) relied on social grants and a further majority (68.3percent) had 1 to 10 years of experience in scavenging chicken production. The majority (84.5percent) of the households had between 1 and 50 chickens, with an overwhelming majority (95percent) practising free range system. Most (74.5percent) of the chicken houses were built with scrap material found within the community. The supplementary feed that was mostly offered to scavenging chickens was maize. The majority (95.7percent) of respondents experienced disease outbreaks, the most dominant of which was the Newcastle disease. Most (94.4percent) of the farmers offered a variety of indigenous medicines, mainly Aloe Ferrox. In addition, the majority (88.8percent) of the respondents experienced predation challenges The primary purpose of rearing scavenging chickens was consumption. Chickens were slaughtered for home consumption while forty-two percent at most. Most (50.9percent) of the respondents indicated that they offered chickens as gifts and as friendly gestures. The majority (82.0percent) indicated that they did not use chicken for any cultural rituals. A large (88.2percent) number of the respondents felt food secured as a result of rearing scavenging chickens, as they access products such as eggs and meat. The majority (98.8percent) of the respondents had never received any form of training from agricultural extension services. The results of the multiple linear regression model revealed that independent variables such as number of chickens, type of cockerels, number of hens, type of housing, type of training and cost of trainings had strong statistical significant values (p<0.001) zero-order correlation with production performance,while age and gender had statistical significant values at (p<0.05) and (p<0.010). For the improvement of the production performance of scavenging chicken production of rural farmers, the study recommends massive campaign among the farmers by agricultural extension services to create awareness on the dangers inherent in the use of unorthodox approaches to treating pests and diseases in scavenging chicken. Scavenging chicken farmers could be supported with simple technologies that are affordable on housing, medication and feed supplements. Training should focus on housing, disease management and feeding of scavenging chickens. , Thesis (MSc) -- Faculty of Science and Agriculture, 2021
- Full Text:
- Date Issued: 2021-03
- Authors: Fentele, Ziphozethu https://orcid.org/ 0000-0001-7939-2964
- Date: 2021-03
- Subjects: Broilers (Chickens) , Poultry -- Breeding
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/21490 , vital:48751
- Description: Scavenging chicken production plays a significant role in the lives of rural farmers as it ensures food security by providing eggs and meat to rural farmers almost in all developing nations. Rural farmers not only consume scavenging chickens, they also sell live chickens to customers to generate immediate income and are able to acquire other products using the money from the sales. The purpose of this study was to investigate production performance, socioeconomic benefits, and agricultural extension services support for scavenging chicken producers. The study was carried out in eight villages in Raymond Mhlaba Local Municipality in the Eastern Cape Province of South Africa. This study employed the multistage sampling technique for data collection from respondents between October and November 2018. The study used descriptive statistics, frequencies, percentages and multiple linear regression models to analyse quantitative data that was collected from a survey of 161 rural farmers that rear scavenging chickens. The results reveal that the majority (68.3percent) of the respondents in Raymond Mhlaba Local Municipality were women, while 52percent were married. Forty-eight percent of the respondents had attained high school education. The majority (53.4percent) relied on social grants and a further majority (68.3percent) had 1 to 10 years of experience in scavenging chicken production. The majority (84.5percent) of the households had between 1 and 50 chickens, with an overwhelming majority (95percent) practising free range system. Most (74.5percent) of the chicken houses were built with scrap material found within the community. The supplementary feed that was mostly offered to scavenging chickens was maize. The majority (95.7percent) of respondents experienced disease outbreaks, the most dominant of which was the Newcastle disease. Most (94.4percent) of the farmers offered a variety of indigenous medicines, mainly Aloe Ferrox. In addition, the majority (88.8percent) of the respondents experienced predation challenges The primary purpose of rearing scavenging chickens was consumption. Chickens were slaughtered for home consumption while forty-two percent at most. Most (50.9percent) of the respondents indicated that they offered chickens as gifts and as friendly gestures. The majority (82.0percent) indicated that they did not use chicken for any cultural rituals. A large (88.2percent) number of the respondents felt food secured as a result of rearing scavenging chickens, as they access products such as eggs and meat. The majority (98.8percent) of the respondents had never received any form of training from agricultural extension services. The results of the multiple linear regression model revealed that independent variables such as number of chickens, type of cockerels, number of hens, type of housing, type of training and cost of trainings had strong statistical significant values (p<0.001) zero-order correlation with production performance,while age and gender had statistical significant values at (p<0.05) and (p<0.010). For the improvement of the production performance of scavenging chicken production of rural farmers, the study recommends massive campaign among the farmers by agricultural extension services to create awareness on the dangers inherent in the use of unorthodox approaches to treating pests and diseases in scavenging chicken. Scavenging chicken farmers could be supported with simple technologies that are affordable on housing, medication and feed supplements. Training should focus on housing, disease management and feeding of scavenging chickens. , Thesis (MSc) -- Faculty of Science and Agriculture, 2021
- Full Text:
- Date Issued: 2021-03
What are the pertinent intersections in the lives of black women at Rhodes University?
- Authors: Gushman, Lutho Phinda
- Date: 2021-10-29
- Subjects: Women, Black South Africa Makhanda , Student movements South Africa Makhanda , Intersectionality (Sociology) , Pluralism , Matrix organization South Africa Makhanda , Women, Black Education (Higher) South Africa Makhanda , Social action South Africa Makhanda , Rhodes University
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190990 , vital:45047
- Description: After the 2016 #FeesMustFall protest(s), higher education institutions were dramatically altered with respect to their institutional cultures; the narratives of those who were historically side-lined and marginalised took centre stage. At Rhodes University social activism was constitutive of three components; a ‘revolt’ against the fee increment; a contestation of the rape culture; and a rejection of the colonial curriculum. These concerns, in their varied articulations, made up different social and academic realities that define(d) Rhodes University and affected how individuals experienced institutional culture. According to Ndlovu (2017) while these expressed acts (in the form of protests and institutional shutdowns) of resistance against the system of higher education subsided after the fees must fall campaign, these served to centre the narratives of the marginalised. Keeping with this thinking, the argument presented in this thesis explores the experiences of black women in higher education after the call towards coordinated resistance. Using qualitative data in the form of narrative interviews, the thesis documents how the participants continued their academic and social life post-resistance. This rupture of resistance created a complex matrix of individual subjectivity where participants engaged with traditional social academic norms in new spaces of resistance; a phenomenon that enlivened the intersectionality that came to define the higher education landscape of the country. This thesis explores the stories of the participant’s as they engage(d) with what is becoming a new institution—that is the University in South Africa, with a case-in-point being Rhodes University—and to understand the power relations and intersections that define their lived experiences. This study found that the reality of existing within the confines of power—with its fluidity—meant that black women operate both within spaces of privilege and oppression simultaneously. As such, and following Vivian May’s (2015) argument, this study concludes that black women are situated and simultaneously constrained by power. Thus spaces of resistance are constantly in flux and determined by their relations within power. , Thesis (MA) -- Faculty of Humanities, Politics and International Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Gushman, Lutho Phinda
- Date: 2021-10-29
- Subjects: Women, Black South Africa Makhanda , Student movements South Africa Makhanda , Intersectionality (Sociology) , Pluralism , Matrix organization South Africa Makhanda , Women, Black Education (Higher) South Africa Makhanda , Social action South Africa Makhanda , Rhodes University
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190990 , vital:45047
- Description: After the 2016 #FeesMustFall protest(s), higher education institutions were dramatically altered with respect to their institutional cultures; the narratives of those who were historically side-lined and marginalised took centre stage. At Rhodes University social activism was constitutive of three components; a ‘revolt’ against the fee increment; a contestation of the rape culture; and a rejection of the colonial curriculum. These concerns, in their varied articulations, made up different social and academic realities that define(d) Rhodes University and affected how individuals experienced institutional culture. According to Ndlovu (2017) while these expressed acts (in the form of protests and institutional shutdowns) of resistance against the system of higher education subsided after the fees must fall campaign, these served to centre the narratives of the marginalised. Keeping with this thinking, the argument presented in this thesis explores the experiences of black women in higher education after the call towards coordinated resistance. Using qualitative data in the form of narrative interviews, the thesis documents how the participants continued their academic and social life post-resistance. This rupture of resistance created a complex matrix of individual subjectivity where participants engaged with traditional social academic norms in new spaces of resistance; a phenomenon that enlivened the intersectionality that came to define the higher education landscape of the country. This thesis explores the stories of the participant’s as they engage(d) with what is becoming a new institution—that is the University in South Africa, with a case-in-point being Rhodes University—and to understand the power relations and intersections that define their lived experiences. This study found that the reality of existing within the confines of power—with its fluidity—meant that black women operate both within spaces of privilege and oppression simultaneously. As such, and following Vivian May’s (2015) argument, this study concludes that black women are situated and simultaneously constrained by power. Thus spaces of resistance are constantly in flux and determined by their relations within power. , Thesis (MA) -- Faculty of Humanities, Politics and International Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
Practicing conciliation: Towards a practical application of the Equal Weight View
- Authors: Hartley, Danyel Jordan
- Date: 2021-10-29
- Subjects: Knowledge, Theory of , Opinion (Philosophy) , Verbal self-defense , Epistemics , Interpersonal relations , Equal Weight View
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/188341 , vital:44745
- Description: The Equal Weight View is a frequently discussed position in the philosophy of disagreement. It holds that when someone disagrees with an epistemic peer, they should adjust their belief to be closer to their peer’s belief. While the reasons for adopting this response to disagreement have been debated, there has been less discussion about its utility as a tool for handling real-world disagreements. In this thesis I pursue a version of the Equal Weight View which is useful in practice. I argue that traditional applications of the Equal Weight View do not reflect its underlying principles when they are used to resolve real-world disagreements. I develop an idealized application of the Equal Weight View that addresses the problems traditional applications face in real-world scenarios. Unfortunately, addressing these problems results in an application that is unrealistically cognitively demanding. The application trades being insensitive to the environment it would be used in for being insensitive to the limits of its user. I suggest that we might be able to save the idealized application and work around those limits by either externalizing or simplifying the most demanding aspects of the application. Externalization is best achieved by making use of some kind of computer assistance. Simplification involves replacing taxing data tracking and computation with heuristic methods. While neither approach is ideal, I argue that both get us closer to resolving disagreements in accordance with the underlying principles of the Equal Weight View than traditional applications do. , Thesis (MA) -- Faculty of Humanities, Philosophy, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Hartley, Danyel Jordan
- Date: 2021-10-29
- Subjects: Knowledge, Theory of , Opinion (Philosophy) , Verbal self-defense , Epistemics , Interpersonal relations , Equal Weight View
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/188341 , vital:44745
- Description: The Equal Weight View is a frequently discussed position in the philosophy of disagreement. It holds that when someone disagrees with an epistemic peer, they should adjust their belief to be closer to their peer’s belief. While the reasons for adopting this response to disagreement have been debated, there has been less discussion about its utility as a tool for handling real-world disagreements. In this thesis I pursue a version of the Equal Weight View which is useful in practice. I argue that traditional applications of the Equal Weight View do not reflect its underlying principles when they are used to resolve real-world disagreements. I develop an idealized application of the Equal Weight View that addresses the problems traditional applications face in real-world scenarios. Unfortunately, addressing these problems results in an application that is unrealistically cognitively demanding. The application trades being insensitive to the environment it would be used in for being insensitive to the limits of its user. I suggest that we might be able to save the idealized application and work around those limits by either externalizing or simplifying the most demanding aspects of the application. Externalization is best achieved by making use of some kind of computer assistance. Simplification involves replacing taxing data tracking and computation with heuristic methods. While neither approach is ideal, I argue that both get us closer to resolving disagreements in accordance with the underlying principles of the Equal Weight View than traditional applications do. , Thesis (MA) -- Faculty of Humanities, Philosophy, 2021
- Full Text:
- Date Issued: 2021-10-29
Green Synthesis of HIV-1 Protease Inhibitors
- Authors: Hartley, Shaun Neil
- Date: 2021-10
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190145 , vital:44967
- Description: Thesis embargoed until October 2022 , Thesis (MSc) -- Faculty of Science, Chemistry, 2021
- Full Text:
- Date Issued: 2021-10
- Authors: Hartley, Shaun Neil
- Date: 2021-10
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190145 , vital:44967
- Description: Thesis embargoed until October 2022 , Thesis (MSc) -- Faculty of Science, Chemistry, 2021
- Full Text:
- Date Issued: 2021-10
An interpretative phenomenological analysis of mothers’ experiences raising an autistic child
- Authors: Hewson, Aimee Jessica
- Date: 2021-10-29
- Subjects: Autism spectrum disorders South Africa , Autism spectrum disorders in children South Africa , Mothers of children with disabilities South Africa , Phenomenological psychology , Qualitative research , Interpretative phenomenological analysis
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190725 , vital:45022
- Description: There has been an increasing research focus on Autism Spectrum Disorder (ASD) and the experiences of those affected by autism. Previous research has demonstrated that mothers experience difficulties in all spheres related to their autistic child. Mothers were focused on exclusively in this study as previous research found that it is mostly mothers who take on the primary caring role for their children. As a result, this research aimed to explore the perceptions and experience of six South African mothers raising their ASD child. This research used a qualitative research approach and an interpretative phenomenological analysis methodology. Two semi-structured interviews were held with each participant, with interviews being audio recorded. After analysis, five themes were found, namely: (1) learning their child has a condition or diagnosis, (2) learning and sharing about ASD, (3) the mothering experience, (4) interventions and cost and (5) supportive resources. Careful anonymisation choices were made in this research to ensure the anonymity of participants as best as possible, due to the recruitment through a gatekeeper organisation and snowball sampling. The main findings of this study were that mothers experienced difficulties and challenges as they navigated the medical world in search of a diagnosis for their child. Mothers also reported following their intuition when it came to their children’s care, interventions, and schooling. The passage of time was a significant issue to mothers, as they described several delays and waiting periods. Mothers also described their concerns regarding their children’s future and the fact that their child would be dependent on them and would not be able to form autonomous mature relationships with others. They also reported various thoughts on disclosing their child’s diagnosis to their children. This research, therefore, added to and expanded upon South African literature on the experiences of mothers raising their ASD child. Concurring with previous research, this project found that mothers experience many challenges in the raising of their ASD child. , Thesis (MSocSci) -- Faculty of Humanities, Psychology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Hewson, Aimee Jessica
- Date: 2021-10-29
- Subjects: Autism spectrum disorders South Africa , Autism spectrum disorders in children South Africa , Mothers of children with disabilities South Africa , Phenomenological psychology , Qualitative research , Interpretative phenomenological analysis
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190725 , vital:45022
- Description: There has been an increasing research focus on Autism Spectrum Disorder (ASD) and the experiences of those affected by autism. Previous research has demonstrated that mothers experience difficulties in all spheres related to their autistic child. Mothers were focused on exclusively in this study as previous research found that it is mostly mothers who take on the primary caring role for their children. As a result, this research aimed to explore the perceptions and experience of six South African mothers raising their ASD child. This research used a qualitative research approach and an interpretative phenomenological analysis methodology. Two semi-structured interviews were held with each participant, with interviews being audio recorded. After analysis, five themes were found, namely: (1) learning their child has a condition or diagnosis, (2) learning and sharing about ASD, (3) the mothering experience, (4) interventions and cost and (5) supportive resources. Careful anonymisation choices were made in this research to ensure the anonymity of participants as best as possible, due to the recruitment through a gatekeeper organisation and snowball sampling. The main findings of this study were that mothers experienced difficulties and challenges as they navigated the medical world in search of a diagnosis for their child. Mothers also reported following their intuition when it came to their children’s care, interventions, and schooling. The passage of time was a significant issue to mothers, as they described several delays and waiting periods. Mothers also described their concerns regarding their children’s future and the fact that their child would be dependent on them and would not be able to form autonomous mature relationships with others. They also reported various thoughts on disclosing their child’s diagnosis to their children. This research, therefore, added to and expanded upon South African literature on the experiences of mothers raising their ASD child. Concurring with previous research, this project found that mothers experience many challenges in the raising of their ASD child. , Thesis (MSocSci) -- Faculty of Humanities, Psychology, 2021
- Full Text:
- Date Issued: 2021-10-29
Development of a 3D bioprinting and standalone bioreactor unit for the production and maintenance of bioscaffolds in vitro
- Authors: Hundling, Jethro Daniel
- Date: 2021-10-29
- Subjects: Bioreactors , Tissue scaffolds , Cell culture , Polyethylene glycol Biotechnology , 3D bioprinting , Poly(ethylene glycol) diacrylate (PEGDA)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192063 , vital:45192
- Description: The most common method for in vitro cell culture currently is to grow a specific cell type in isolation, in monolayer format, adhered to a 2D culture surface. This brings about many limitations in comparison to in vivo models due to altered cell phenotypes, as caused by the culturing technique itself, and the lack of naturally occurring cell-to-cell interactions. Three dimensional mammalian cell culture technologies have the potential to overcome these limitations, and provide models more representative of natural systems. Unfortunately, the cost and difficulty associated with achieving sustainable and useful 3D mammalian cell culture is still very high, preventing its widespread adoption across scientific platforms. In this research, we investigate the feasibility of developing and producing a visible light-based 3D stereolithographic bioprinter to produce 3D scaffolds for cell culture. Furthermore, we investigate the possibility of developing and implementing a forced perfusion bioreactor system, which would support the produced scaffold and improve longer-term culture conditions. The developed 3D bioprinter, and bioreactor designs were developed and tested alongside Poly (ethylene glycol) diacrylate (PEGDA), a versatile synthetic scaffold material. PEGDA itself was also evaluated for its printability, robustness in culture conditions over time, and its ability to maintain 3D mammalian cell culture. This research showed that both the developed 3D bioprinter, and bioreactor unit were capable of producing and maintaining an easily modifiable PEGDA scaffold, in culture conditions. In addition, the PEGDA formulation developed was shown to allow for the effective and reproducible 3D cell culture conditions over the medium term, with automated media feeding. The research presented here aimed to illustrate a proof of concept that the low-cost development and production of 3D culture scaffold production and maintenance systems was feasible to the scientific research environment. This technology can then be built upon, into a system that would then allow for the broader adoption and investigation of 3D cell culture as a tool within the scientific community. , Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Hundling, Jethro Daniel
- Date: 2021-10-29
- Subjects: Bioreactors , Tissue scaffolds , Cell culture , Polyethylene glycol Biotechnology , 3D bioprinting , Poly(ethylene glycol) diacrylate (PEGDA)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192063 , vital:45192
- Description: The most common method for in vitro cell culture currently is to grow a specific cell type in isolation, in monolayer format, adhered to a 2D culture surface. This brings about many limitations in comparison to in vivo models due to altered cell phenotypes, as caused by the culturing technique itself, and the lack of naturally occurring cell-to-cell interactions. Three dimensional mammalian cell culture technologies have the potential to overcome these limitations, and provide models more representative of natural systems. Unfortunately, the cost and difficulty associated with achieving sustainable and useful 3D mammalian cell culture is still very high, preventing its widespread adoption across scientific platforms. In this research, we investigate the feasibility of developing and producing a visible light-based 3D stereolithographic bioprinter to produce 3D scaffolds for cell culture. Furthermore, we investigate the possibility of developing and implementing a forced perfusion bioreactor system, which would support the produced scaffold and improve longer-term culture conditions. The developed 3D bioprinter, and bioreactor designs were developed and tested alongside Poly (ethylene glycol) diacrylate (PEGDA), a versatile synthetic scaffold material. PEGDA itself was also evaluated for its printability, robustness in culture conditions over time, and its ability to maintain 3D mammalian cell culture. This research showed that both the developed 3D bioprinter, and bioreactor unit were capable of producing and maintaining an easily modifiable PEGDA scaffold, in culture conditions. In addition, the PEGDA formulation developed was shown to allow for the effective and reproducible 3D cell culture conditions over the medium term, with automated media feeding. The research presented here aimed to illustrate a proof of concept that the low-cost development and production of 3D culture scaffold production and maintenance systems was feasible to the scientific research environment. This technology can then be built upon, into a system that would then allow for the broader adoption and investigation of 3D cell culture as a tool within the scientific community. , Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2021
- Full Text:
- Date Issued: 2021-10-29
Inkcitha nzila nobomi obutsha (The release of the widow and life after mourning): Xhosa widows and citizenship
- Jimlongo, Gcotyelwa Nomxolisi
- Authors: Jimlongo, Gcotyelwa Nomxolisi
- Date: 2021-10-29
- Subjects: Widows South Africa Eastern Cape , Women, Black South Africa Eastern Cape , Xhosa (African people) South Africa Eastern Cape , Widows Social conditions , Widowhood Psychological aspects South Africa Eastern Cape , Widowhood Economic aspects South Africa Eastern Cape , Widowhood Social aspects South Africa Eastern Cape , Mourning customs South Africa Eastern Cape , Feminist economics South Africa Eastern Cape
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192220 , vital:45206
- Description: This study examines the everyday conceptions and navigations of citizenship by Xhosa widows. It examines widows’ own understandings and experiences of citizenship once the official mourning period, known amongst amaXhosa as ukuzila, has ended. The study draws from 14 interviews with Xhosa widows from the Amalinda, Tsholomnqa, Mdantsane, Magcumeni, KwaNonkcampa, and Dimbaza areas in the Eastern Cape, South Africa. This thesis contextualises claims to widowhood in the context of democratic South Africa, and the various ways in which widowed women conceptualise their lives after ukuzila. While ukuzila itself is written about in the literature, the contentious claims to widowhood and the ways in which women come to make sense of their lives in the post-mourning period remains largely unexplored. Interviews were conducted with women who had undertaken customary and/or civil marriages, had divorced or separated from their partners, or had cohabited. They reveal that widowhood is tenuous and as such, remains contested and contestable. The study demonstrates that much of the claims to widowhood are made because of the undeniable labour that women perform during the partnerships, where they are the primary economic providers. The study shows that whether in the formal and informal sector, women have been central in building the economic livelihoods of their families. In the post-mourning period, the theme of ukuhlala (to stay) that is articulated by widows, shows that they choose to remain in their marital homes to protect what they have laboured for. The findings demonstrate that the key to ‘good’ widowhood is intricately linked to ‘good’ motherhood. For Xhosa widows, much of their decision-making, and livelihood strategies, rests on how they craft good livelihoods for their families. These include a negotiation of feminist economies with woman-centred networks, a reliance on spirituality, as well as negotiations for dignity and respect within the homestead through the protection and maintenance of what they have built over the years. , Thesis (MA) -- Faculty of Humanities, Political and International Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Jimlongo, Gcotyelwa Nomxolisi
- Date: 2021-10-29
- Subjects: Widows South Africa Eastern Cape , Women, Black South Africa Eastern Cape , Xhosa (African people) South Africa Eastern Cape , Widows Social conditions , Widowhood Psychological aspects South Africa Eastern Cape , Widowhood Economic aspects South Africa Eastern Cape , Widowhood Social aspects South Africa Eastern Cape , Mourning customs South Africa Eastern Cape , Feminist economics South Africa Eastern Cape
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192220 , vital:45206
- Description: This study examines the everyday conceptions and navigations of citizenship by Xhosa widows. It examines widows’ own understandings and experiences of citizenship once the official mourning period, known amongst amaXhosa as ukuzila, has ended. The study draws from 14 interviews with Xhosa widows from the Amalinda, Tsholomnqa, Mdantsane, Magcumeni, KwaNonkcampa, and Dimbaza areas in the Eastern Cape, South Africa. This thesis contextualises claims to widowhood in the context of democratic South Africa, and the various ways in which widowed women conceptualise their lives after ukuzila. While ukuzila itself is written about in the literature, the contentious claims to widowhood and the ways in which women come to make sense of their lives in the post-mourning period remains largely unexplored. Interviews were conducted with women who had undertaken customary and/or civil marriages, had divorced or separated from their partners, or had cohabited. They reveal that widowhood is tenuous and as such, remains contested and contestable. The study demonstrates that much of the claims to widowhood are made because of the undeniable labour that women perform during the partnerships, where they are the primary economic providers. The study shows that whether in the formal and informal sector, women have been central in building the economic livelihoods of their families. In the post-mourning period, the theme of ukuhlala (to stay) that is articulated by widows, shows that they choose to remain in their marital homes to protect what they have laboured for. The findings demonstrate that the key to ‘good’ widowhood is intricately linked to ‘good’ motherhood. For Xhosa widows, much of their decision-making, and livelihood strategies, rests on how they craft good livelihoods for their families. These include a negotiation of feminist economies with woman-centred networks, a reliance on spirituality, as well as negotiations for dignity and respect within the homestead through the protection and maintenance of what they have built over the years. , Thesis (MA) -- Faculty of Humanities, Political and International Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
Nonlinear optical properties of metal free thio alkyl and tert-butyl phenoxy phthalocyanine
- Authors: Joseph, Otto
- Date: 2021-10
- Subjects: Nonlinear optics , Phthalocyanines , Time-dependent density functional theory , Magnetic circular dichroism , Reverse saturable absorption (RSA) , Real Time Dependent Density Functional Theory (RT-TDDFT)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190712 , vital:45021
- Description: This work reports on the nonlinear optical properties of tetra - and octa substituted phthalocyanines (Pcs) utilising pentane thiol and 4-tertbutyl phenol as substituents. Their nonlinear absorption coefficient (𝛽) and absorption cross sections were determined using the Z-scan technique with a 10 ns pulse laser at 532 nm. The molecular second order hyperpolarizability Im[γ] was observed and the following Im[γ] trend was obtained for 𝛼-H2Pc(SC5H11)4 isomers, 5.93 ×10−31 (Cs) 2.24×10−32(D2h) > 1.21×10−32(C4h) > 1.05×10−32 (C2v) esu, respectively, in chloroform. Symmetry was seen to have an effect on the observed reverse saturable absorption (RSA) response. Based on the five level model rate equation nonlinear fit of the RSA response curves and Real Time Time Dependant Density Functional Theory (RT-TDDFT) results, the singlet excited state population dynamics was found to play a significant role in producing the observed Im[γ] trend. , Thesis (MSc) -- Faculty of Science, Chemistry, 2021
- Full Text:
- Date Issued: 2021-10
- Authors: Joseph, Otto
- Date: 2021-10
- Subjects: Nonlinear optics , Phthalocyanines , Time-dependent density functional theory , Magnetic circular dichroism , Reverse saturable absorption (RSA) , Real Time Dependent Density Functional Theory (RT-TDDFT)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190712 , vital:45021
- Description: This work reports on the nonlinear optical properties of tetra - and octa substituted phthalocyanines (Pcs) utilising pentane thiol and 4-tertbutyl phenol as substituents. Their nonlinear absorption coefficient (𝛽) and absorption cross sections were determined using the Z-scan technique with a 10 ns pulse laser at 532 nm. The molecular second order hyperpolarizability Im[γ] was observed and the following Im[γ] trend was obtained for 𝛼-H2Pc(SC5H11)4 isomers, 5.93 ×10−31 (Cs) 2.24×10−32(D2h) > 1.21×10−32(C4h) > 1.05×10−32 (C2v) esu, respectively, in chloroform. Symmetry was seen to have an effect on the observed reverse saturable absorption (RSA) response. Based on the five level model rate equation nonlinear fit of the RSA response curves and Real Time Time Dependant Density Functional Theory (RT-TDDFT) results, the singlet excited state population dynamics was found to play a significant role in producing the observed Im[γ] trend. , Thesis (MSc) -- Faculty of Science, Chemistry, 2021
- Full Text:
- Date Issued: 2021-10
“This may not be your grandmother’s page, but we will definitely talk about her”: Lusaka women and the Zambian Feminists Facebook page
- Authors: Kasanga, Chishimba
- Date: 2021-10-29
- Subjects: Feminists Zambia , Social media and society Zambia , Facebook (Firm) , Feminism Africa , Women Zambia Social conditions , Sex role Zambia , Patriarchy Zambia , Digital activism , Zambian Feminists
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190122 , vital:44965
- Description: The internet has facilitated the creation of a global community of feminists who use it both for discussion and activism. Recently, high-profile campaigns, such as #MeToo and #AmINext, have garnered massive support online, attracting tens of thousands of women in diverse social and geographical spaces who have used the internet as forums for discussion and a route for activism. However, there are still parts of the world where feminism is a contentious topic, and one such place is Zambia, where the Facebook page Zambian Feminists, seeks to challenge patriarchy and gender non-conformity in a highly heteronormative society. This study investigates how prolific women fans of the Zambian Feminists page contest, negotiate and appropriate meanings from the posts and associated comments into their lives as “everyday feminists”. As a reception study, it inquires into how Lusaka women fans of the page negotiate their roles as strong feminists online and their offline social roles as women, mothers, daughters and wives living in a patriarchal and conservative society. The study draws primarily on qualitative research methods, specifically qualitative focus group discussions and individual in-depth interviews, to investigate this audience’s reception of the page’s content. The study establishes that Zambian Feminists is consumed in a complex environment where contesting notions of Christianity, traditionalism, and modernity are at play. The study also shows how a Christian nationalism discourse acts as a stumbling block to women fans identifying as feminists and women fans who identify as members of the LGBTIQ community, as they must negotiate and construct their identity against this prevailing discourse. The study concludes that inasmuch as the Zambian Feminist page provides a platform for women to ‘call out’ and challenge patriarchy, sexism and misogyny, the offline space is more difficult to overcome; Zambian women continue to conform to patriarchal norms as they construct and negotiate their feminism in line with the broader societal gender order. , Thesis (MA) -- Faculty of Humanities, Journalism and Media Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Kasanga, Chishimba
- Date: 2021-10-29
- Subjects: Feminists Zambia , Social media and society Zambia , Facebook (Firm) , Feminism Africa , Women Zambia Social conditions , Sex role Zambia , Patriarchy Zambia , Digital activism , Zambian Feminists
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190122 , vital:44965
- Description: The internet has facilitated the creation of a global community of feminists who use it both for discussion and activism. Recently, high-profile campaigns, such as #MeToo and #AmINext, have garnered massive support online, attracting tens of thousands of women in diverse social and geographical spaces who have used the internet as forums for discussion and a route for activism. However, there are still parts of the world where feminism is a contentious topic, and one such place is Zambia, where the Facebook page Zambian Feminists, seeks to challenge patriarchy and gender non-conformity in a highly heteronormative society. This study investigates how prolific women fans of the Zambian Feminists page contest, negotiate and appropriate meanings from the posts and associated comments into their lives as “everyday feminists”. As a reception study, it inquires into how Lusaka women fans of the page negotiate their roles as strong feminists online and their offline social roles as women, mothers, daughters and wives living in a patriarchal and conservative society. The study draws primarily on qualitative research methods, specifically qualitative focus group discussions and individual in-depth interviews, to investigate this audience’s reception of the page’s content. The study establishes that Zambian Feminists is consumed in a complex environment where contesting notions of Christianity, traditionalism, and modernity are at play. The study also shows how a Christian nationalism discourse acts as a stumbling block to women fans identifying as feminists and women fans who identify as members of the LGBTIQ community, as they must negotiate and construct their identity against this prevailing discourse. The study concludes that inasmuch as the Zambian Feminist page provides a platform for women to ‘call out’ and challenge patriarchy, sexism and misogyny, the offline space is more difficult to overcome; Zambian women continue to conform to patriarchal norms as they construct and negotiate their feminism in line with the broader societal gender order. , Thesis (MA) -- Faculty of Humanities, Journalism and Media Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
In silico identification of natural inhibitory compounds against the Mycobacterium tuberculosis Enzyme Pyrazinamidase using high-throughput virtual screening techniques
- Authors: Kenyon, Thomas
- Date: 2021-10-29
- Subjects: Mycobacterium tuberculosis , Pyrazinamide , Molecular dynamics , High throughput screening (Drug development) , Mutagenesis , South African Natural Compounds database (SANCDB)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192074 , vital:45193
- Description: Tuberculosis (TB) is most commonly a pulmonary infection caused by the bacterium Mycobacterium tuberculosis. With the exception of the COVID-19 pandemic, TB was the most common cause of death due to an infectious disease for a number of years up until 2020. In 2019, 10 million people fell ill with TB worldwide and 1.4 million people died (WHO, 2020a). Additionally, multidrug-resistant TB (MDR-TB) remains a public health crisis and a health security threat. A global total of 206 030 people with multidrug- or rifampicin-resistant TB (MDR/RR-TB) were reported in 2019, a 10% increase from 186 883 in 2018. South Africa is ranked among the 48 high TB burden countries, with an estimated 360 000 people falling ill in 2019, resulting in 58 000 deaths, the majority of which being among people living with HIV. Unlike HIV, however, TB is a curable disease when managed correctly with long durations of antitubercular chemotherapy. Pyrazinamide (PZA) is an important first-line tuberculosis drug unique for its activity against latent TB. PZA is a prodrug, being converted into its active form, pyrazinoic acid (POA) by the Mtb gene pncA, coding for the pyrazinamidase enzyme (PZase). TB resistance to first-line drugs such as PZA is commonly associated with mutations in the pncA/PZase enzyme. This study aimed to identify potential novel inhibitors that bind to the active site of PZase. By making use of molecular docking studies and molecular dynamics (MD) simulations, high throughput virtual screening was performed on 623 compounds from the South African Natural Compounds database (SANCDB; https://sancdb.rubi.ru.ac.za). Ligands that selectively bound to the PZase active site were identified using docking studies, followed by MD simulations to assess ligand-PZase complex stability, Finally, hit compounds identified from the first round of MD simulations were screened again against PZase structures with high confidence point mutations known to infer PZA resistance in order to identify any novel compounds which had inhibitory potential against both WT and mutant forms of the PZase enzyme. , Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Kenyon, Thomas
- Date: 2021-10-29
- Subjects: Mycobacterium tuberculosis , Pyrazinamide , Molecular dynamics , High throughput screening (Drug development) , Mutagenesis , South African Natural Compounds database (SANCDB)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192074 , vital:45193
- Description: Tuberculosis (TB) is most commonly a pulmonary infection caused by the bacterium Mycobacterium tuberculosis. With the exception of the COVID-19 pandemic, TB was the most common cause of death due to an infectious disease for a number of years up until 2020. In 2019, 10 million people fell ill with TB worldwide and 1.4 million people died (WHO, 2020a). Additionally, multidrug-resistant TB (MDR-TB) remains a public health crisis and a health security threat. A global total of 206 030 people with multidrug- or rifampicin-resistant TB (MDR/RR-TB) were reported in 2019, a 10% increase from 186 883 in 2018. South Africa is ranked among the 48 high TB burden countries, with an estimated 360 000 people falling ill in 2019, resulting in 58 000 deaths, the majority of which being among people living with HIV. Unlike HIV, however, TB is a curable disease when managed correctly with long durations of antitubercular chemotherapy. Pyrazinamide (PZA) is an important first-line tuberculosis drug unique for its activity against latent TB. PZA is a prodrug, being converted into its active form, pyrazinoic acid (POA) by the Mtb gene pncA, coding for the pyrazinamidase enzyme (PZase). TB resistance to first-line drugs such as PZA is commonly associated with mutations in the pncA/PZase enzyme. This study aimed to identify potential novel inhibitors that bind to the active site of PZase. By making use of molecular docking studies and molecular dynamics (MD) simulations, high throughput virtual screening was performed on 623 compounds from the South African Natural Compounds database (SANCDB; https://sancdb.rubi.ru.ac.za). Ligands that selectively bound to the PZase active site were identified using docking studies, followed by MD simulations to assess ligand-PZase complex stability, Finally, hit compounds identified from the first round of MD simulations were screened again against PZase structures with high confidence point mutations known to infer PZA resistance in order to identify any novel compounds which had inhibitory potential against both WT and mutant forms of the PZase enzyme. , Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-10-29
Curriculum adjustment and adaptive leadership in two service-learning courses at Rhodes University as a consequence of the COVID-19 pandemic
- Authors: Khuhlane, Heide Nozuko
- Date: 2021-10-29
- Subjects: COVID-19 (Disease) , Curriculum planning South Africa Makhanda , Rhodes University , Service learning South Africa Makhanda , Educational leadership South Africa Makhanda , Educational change South Africa Makhanda , Adaptive leadership
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/191192 , vital:45069
- Description: The COVID-19 global pandemic altered many aspects of learning. Learning through service, a component of community engagement in higher education linking academic learning and the community was no exception. Informed by Experiential Learning Theory, this study investigated the curriculum adjustment of two service-learning courses at Rhodes University and the leadership development of those who lead the courses as a consequence of COVID-19. The study’s initial goal was to highlight the position of service-learning as a component of academic learning. With the onset of the COVID-19 pandemic the goal was extended to understanding the impact of the pandemic not only on service-learning, but on leadership as well. Furthermore, the study sought to determine the responsiveness of service-learning policies at Rhodes University at a time of crisis. The study was designed as an interpretivist case study with four participants and one secondary participant. The study employed document analysis, individual interviews and a focus group interview to collect data. Data analysis took the form of content analysis and coding, through the lens of Experiential Learning Theory and an alternative service-based model. The study findings revealed that as a result of the COVID-19 global pandemic both service-learning courses had to be adapted to ensure successful completion. The adaptations included attention to scaffolded learning, assessment and course outcomes; in one course the service engagement aspect with the community was lost entirely to ensure the saftey of students through adherence to COVID-19 safety regulations. The study also found that the participants developed adaptive leadership competencies and skills, technological and collaboration skills as well as a heightened regard for pastoral care and social justice. However, it was evident that the pandemic revealed gaps in the conceptual understanding of service-learning in the context of the two courses, a need for responsive policy, and practical strategies to implement those policies in smaller units in the institution. The study thus recommends an alternative service-based model approach to service-learning, increased policy responsiveness to issues posed by the ‘new normal’ to support adaptive leadership development, re-defining of the university-community partnership and the identification of opportunities for innovation and collaboration intra-departmentally through service-learning. , Thesis (MEd) -- Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Khuhlane, Heide Nozuko
- Date: 2021-10-29
- Subjects: COVID-19 (Disease) , Curriculum planning South Africa Makhanda , Rhodes University , Service learning South Africa Makhanda , Educational leadership South Africa Makhanda , Educational change South Africa Makhanda , Adaptive leadership
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/191192 , vital:45069
- Description: The COVID-19 global pandemic altered many aspects of learning. Learning through service, a component of community engagement in higher education linking academic learning and the community was no exception. Informed by Experiential Learning Theory, this study investigated the curriculum adjustment of two service-learning courses at Rhodes University and the leadership development of those who lead the courses as a consequence of COVID-19. The study’s initial goal was to highlight the position of service-learning as a component of academic learning. With the onset of the COVID-19 pandemic the goal was extended to understanding the impact of the pandemic not only on service-learning, but on leadership as well. Furthermore, the study sought to determine the responsiveness of service-learning policies at Rhodes University at a time of crisis. The study was designed as an interpretivist case study with four participants and one secondary participant. The study employed document analysis, individual interviews and a focus group interview to collect data. Data analysis took the form of content analysis and coding, through the lens of Experiential Learning Theory and an alternative service-based model. The study findings revealed that as a result of the COVID-19 global pandemic both service-learning courses had to be adapted to ensure successful completion. The adaptations included attention to scaffolded learning, assessment and course outcomes; in one course the service engagement aspect with the community was lost entirely to ensure the saftey of students through adherence to COVID-19 safety regulations. The study also found that the participants developed adaptive leadership competencies and skills, technological and collaboration skills as well as a heightened regard for pastoral care and social justice. However, it was evident that the pandemic revealed gaps in the conceptual understanding of service-learning in the context of the two courses, a need for responsive policy, and practical strategies to implement those policies in smaller units in the institution. The study thus recommends an alternative service-based model approach to service-learning, increased policy responsiveness to issues posed by the ‘new normal’ to support adaptive leadership development, re-defining of the university-community partnership and the identification of opportunities for innovation and collaboration intra-departmentally through service-learning. , Thesis (MEd) -- Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-10-29
Hop-mediated alteration of cellular metabolism in KSHV infection
- Authors: Kirigin, Elisa
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192477 , vital:45229
- Description: Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Kirigin, Elisa
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192477 , vital:45229
- Description: Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-10-29