- Title
- Effect of fluoroquinolones antibiotics on vancomycin and oxacillin resistant staphylococcus species in Eastern Cape Province
- Creator
- Soyege, Oludotun
- Subject
- Staphylococcus aureus
- Subject
- Quinolone antibacterial agents
- Subject
- Fluoroquinolones
- Date
- 2012
- Type
- Master's theses
- Type
- text
- Identifier
- http://hdl.handle.net/10353/25349
- Identifier
- vital:64212
- Description
- This study shows the susceptibility profile of some Staphylococcus species isolated from commensal Staphylococci in Nkonkobe municipality, South Africa. A total number of 120 Staphylococcal isolates were screened for their susceptibilities to various classes of antibiotics such as Aminoglycoside (Gentamycin), Aminoglycoside (Kanamycin), Macrolide (Erythromycin), Tetracycline (Minocycline), Anti-tuberculous (Rifampicin), Lincosamides (Clindamycin), Cephalosporin and Fluoroquinolones in general. During the study, 32 (26percent) the test organisms were susceptible to both methicillin and vancomycin, while 12 (10percent) had co-resistance to the antibiotics. Furthermore, Gentamycin (an Aminoglycoside) had a relatively high potency against the isolates with 107 (89.17percent) of the bacteria being susceptible to it, while 10 (8.33percent) were resistant. On the other hand, Erythromycin (a Macrolide) was active against 72 (60percent) of the isolates, while 5 (4.17percent) and 74 (61.67percent) of the isolates yielded intermediate and resistant responses respectively. In addition , 51 (42.5percent) of the isolates were susceptible to rifampicin, while 1 (0.83percent) and 17 (14.17percent) were intermediate and resistant respectively. Ten percent of the isolates screened for their antibiotic susceptibility pattern in this study were positive for mecA gene among the vancomycin-oxacillin resistant strains while van gene was not detected in any of the isolates. This shows how the synergy of both vancomycin and oxacillin contribute to some resistance nature of Staphylococci. In order to overcome this resistance attributes of Staphylococci, to the commonly used antibiotics as discussed under this context, various types of fluoroquinolones were tested. The result shows that less than 10percent of the isolates were generally resistant to the fluoroquinolones except against Nalidix acid to which all the isolates were resistant. Other antibiotics had relatively higher resistance patterns as observed for minocycline (39.51percent), clindamycin (12.75percent), gentamycin (12.31percent) and vancomycin (12.3percent). The new generation fluoroquinolones including Gatifloxacin, Levofloxacin, Moxifloxacin and Ciprofloxacin to which less than 5percent of the bacteria are resistant gives some clinical advantage over the Methicillin and Vancomycin resistant strains. About 31percent of the isolates had multiple antibiotic resistance index of ≥1 and suggests animals in the community as potential reservoirs of antibiotic resistance determinants in the environment. Data obtained in this study is of epidemiological importance and valuable for disease control.
- Description
- Thesis (MSc) -- Faculty of Science and Agriculture, 2012
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (61 leaves)
- Format
- Publisher
- University of Fort Hare
- Publisher
- Faculty of Science and Agriculture
- Language
- English
- Rights
- University of Fort Hare
- Rights
- All Rights Reserved
- Rights
- Open Access
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UFH Department of Biochemistry & Microbiology
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Soyege.pdf | 472 KB | Adobe Acrobat PDF | View Details Download |