List of Titles

Quick View

Editorial for Special Issue: Education for Sustainability in a Time of Crises

- Rosenberg, Eureta

Authors: Rosenberg, Eureta
Date: 2020
Subjects: To be catalogued
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/370533 , vital:66352 , xlink:href="10.4314/sajee.v36i1.1"
Description: There is an old and still popular saying that a crisis is an opportunity for change. The Chinese symbol for crisis is translated in Wikipedia as “danger at a point of juncture”. In the year 2020, first China and then the rest of humanity have been presented with a monumental crisis: a new and lethal virus that spread fast and far, causing actions and reactions, with dramatic consequences for social and economic life around the globe. Rebecca Solnit wrote of another crisis in her book Hope in the Dark: The Untold Story of People Power. In Grounds for Hope, a foreword to the 2015 edition (p.2), she stated: “This is an extraordinary time full of vital, transformative movements, that could not be foreseen. It’s also a nightmarish time. Full engagement requires the ability to perceive both.”.
Full Text:
Date Issued: 2020

Quick View

Enhancement of photodynamic antimicrobialtherapy through the use of cationic indium porphyrin conjugated to Ag/CuFe2O4 nanoparticles

- Makola, Collen L, Managa, Muthumuni, Nyokong, Tebello

Authors: Makola, Collen L , Managa, Muthumuni , Nyokong, Tebello
Date: 2020
Subjects: To be catalogued
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/186233 , vital:44475 , xlink:href="https://doi.org/10.1016/j.pdpdt.2020.101736"
Description: Photodynamic antimicrobial chemotherapy (PACT) is being actively researched as a possible alternative for antimicrobial agents. This study focuses on the application of neutral indium 5-p-carboxyphenyl-10-15-20-(tri-4-pyridyl)porphyrin and cationic indium 5-p-carboxyphenyl-10-15-20-(tris-4-methylpyridyl)-porphyrin triiodide conjugated to 6-mercapo-1-hexanol functionalized Ag/CuFe2O4 magnetic nanoparticles for photo-inactivation of S. aureus bacteria. Comparative studies were done on quaternized and unquaternized indium porphyrin complexes conjugated to Ag/CuFe2O4, where log reduction of 9.27 was obtained for quaternized conjugate and 0.83 for unquaternized conjugate.
Full Text:
Date Issued: 2020

Quick View

Direct nonlinear optical absorption measurements of asymmetrical zinc (II) phthalocyanine when covalently linked to semiconductor quantum dots

- Mgidlana, Sithi, Sen, Pinar, Nyokong, Tebello

Authors: Mgidlana, Sithi , Sen, Pinar , Nyokong, Tebello
Date: 2020
Subjects: To be catalogued
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/186056 , vital:44459 , xlink:href="https://doi.org/10.1016/j.molstruc.2020.128729"
Description: We report on nonlinear optical properties of tris[(4-tert-butyl)-2-thio (phenyl)acetic acid (1) and tris(dimethyl-5-(3,4-phenoxy) isophthalate (2) phthalocyaninato zinc (II) complexes. The synthesized complexes were covalently conjugated to glutathione-capped CdTe/ZnSe/ZnO quantum dots. We observed an increase in triplet quantum yield with corresponding decrease in fluorescence quantum yield of conjugates compared to Pc complexes alone. Z-scan technique was employed to experimentally test the nonlinear optical response of complexes and nanoconjugates in solution at laser excitation wavelength of 532 nm with 7 ns pulse. Nonlinear absorption coefficient, third-order optical susceptibility and optical limiting threshold of the materials were obtained from the Z-scan data. The nonlinear absorption parameters improved in the presence of CdTe/ZnSe/ZnO, with 1 and 1-CdTe/ZnSe/ZnO, giving the best results due to the presence of electron donating substituents.
Full Text:
Date Issued: 2020

Quick View

An octabrominated Sn (iv) tetraisopropylporphyrin as a photosensitizer dye for singlet oxygen biomedical applications

- Babu, Balaji, Mack, John, Nyokong, Tebello

Authors: Babu, Balaji , Mack, John , Nyokong, Tebello
Date: 2020
Subjects: To be catalogued
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/186679 , vital:44524 , xlink:href="https://doi.org/10.1039/D0DT01915A"
Description: Two novel Sn(IV) tetraisopropylphenylporphyrins have been synthesized to explore the effect of octabromination at the β-pyrrole positions on their photophysical properties and photodynamic activity. The lower energy Q band of an octabrominated complex lies at 675 nm well within the therapeutic window. The octabrominated dye has a relatively high singlet oxygen quantum yield of 0.78 in DMF and exhibits favorable photodynamic activity against MCF-7 cells with an IC50 value of 10.7 μM and a 5.74 log reduction value (5 μM) towards S. aureus under illumination at 660 nm for 60 min with a Thorlabs M660L3 LED (280 mW cm−2).
Full Text:
Date Issued: 2020

Quick View

Synthesis of peptidomimetic compounds as HIV-1 protease inhibitors

- Kayembe, Jean-Pierre

Authors: Kayembe, Jean-Pierre
Date: 2020
Subjects: Protease inhibitors , HIV (Viruses) , HIV infections Treatment , Peptidomimetics‎
Language: English
Type: Doctoral theses , text
Identifier: http://hdl.handle.net/10962/124397 , vital:35604 , DOI https://dx.doi.org/10.21504/10962/124397
Description: This research project has involved the design, synthesis and evaluation of novel peptidomimetics compounds as HIV-1 protease inhibitors. Here is presented one-step, two-step and three-step syntheses and the in vitro bio-assay studies of a series of fully characterized peptidomimetics as HIV-1 protease inhibitors candidate using the shortest and most cost effective synthetic routes. The first series of compounds were accessed via a synthetic elaboration of Morita-Baylis-Hillman adducts by a Michael addition with benzylamine, proline or glycine esters to afford a series of β-amino-β’-hydroxycarboxylate esters in moderate to good yields. Base-catalyzed cyclization of non-benzylated aza-Michael adducts afforded a series of coumarin-3-hydroxy-2-methylenepropanoate esters in moderate yields. The uncatalyzed direct amidation of diethyl tartrate/tartaric acid and tartaric acid osazone with selected amines/amino acids afforded a series of C2-symmetrical and unsymmetrical 1,2-dihydroxycarboxylates in moderate to very high yields. All the synthesized compounds were fully characterized using spectroscopic techniques. These conjugates, designed as potential HIV-1 inhibitors, were tested against the HIV-1 protease enzyme. A number of these ligands have exhibited inhibition levels and IC50 values comparable to ritonavir, permitting, therefore, their identification as lead compounds for the development of novel inhibitors. , Thesis (PhD) -- Faculty of Science, Chemistry, 2020
Full Text: false
Date Issued: 2020

Quick View

Men in Women’s Clothes

- Jones, Ward E

Authors: Jones, Ward E
Date: 2020
Subjects: To be catalogued
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/275658 , vital:55067 , xlink:href="https://doi.org/10.1111/sjp.12394"
Description: The descriptive phrase that comprises my title can refer both to a pervasive comic trope and a mode of self-expression. There is a tension here, insofar as the comic trope leads us not to take cross-dressing, or drag, seriously. The first half of the comic film Some Like It Hot (1959), with its cross-gender plot and its (sophisticated but) straightforward use of the comic trope of men-in-women’s clothes, appears to fall foul of this tension and to be susceptible to criticism in this regard. However, the film rectifies itself, portraying the cross-dressing relationship which develops through the second half of the film as a potentially meaningful one for both partners. In this article, I interpret the film as inviting its viewers to adopt a (particular kind of) skeptical ironic (that is, Pyrrhonian) attitude toward gender-presentation practices. While the film in no way attempts to discourage us from participating in such practices, it does invite us—through our partiality toward the characters Osgood and Jerry/Daphne, as we follow their budding, transgressive relationship—to acknowledge that a violation of gender-presentation practices can be a meaningful feature of sincere relationships.
Full Text:
Date Issued: 2020

Quick View

The Unintended Consequences of Using Direct Incentives to Drive the Complex Task of Research Dissemination

- Muthama, Evelyn, McKenna, Sioux

Authors: Muthama, Evelyn , McKenna, Sioux
Date: 2020
Subjects: To be catalogued
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/187116 , vital:44569 , xlink:href="https://doi.org/10.25159/1947-9417/6688"
Description: Universities have used an array of incentives to increase academic publications, which are highly rewarded in the South African higher education funding formula. While all universities use indirect incentives, such as linking promotion and probation to publication, the mechanisms used in some institutions have taken a very direct form, whereby authors are paid to publish. This process has paralleled a large rise in publication outputs alongside increased concerns about quality. Significantly, there are ethical questions to be asked when knowledge dissemination is so explicitly linked to financial reward through the payment of commission to academics. Based on an analysis of institutional policies and data from an online survey and interviews with academics from seven South African universities, we argue that when money is the main means used to encourage academics to contribute to knowledge, numerous unintended consequences may emerge. These include a focus on quantity rather than the quality of research, a rise in predatory publishing, and resentment among academics. We argue that incentives, in particular direct payment for publications, undermine the academic project by positioning publications in terms of exchange-value rather than their use-value as a contribution to knowledge building.
Full Text:
Date Issued: 2020

Quick View

Development of phthalocyanine functionalised TiO 2 and ZnO nanofibers for photodegradation of methyl orange

- Mapukata, Sivuyisiwe, Nyokong, Tebello

Authors: Mapukata, Sivuyisiwe , Nyokong, Tebello
Date: 2020
Subjects: To be catalogued
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/186323 , vital:44485 , xlink:href="https://doi.org/10.1039/D0NJ03326J"
Description: The photocatalytic activity of TiO2 and ZnO based catalysts, which is based on their ability to generate electron–hole pairs upon photoillumination is limited due to their wide band gaps and lack of efficient retrievability post-application. This work reports on the fabrication, characterisation and comparison of electrospun TiO2 and ZnO nanofibers when bare vs when functionalised with a phthalocyanine. The generated photocatalysts are attractive because they absorb visible light and are easily retrievable and hence reusable. With the Pc anchored onto their surfaces, the anatase TiO2 nanofibers and the wurzite ZnO nanofibers possessed singlet oxygen quantum yields of 0.22 and 0.16 in water, respectively. Evaluation of the photocatalytic efficiencies of the nanofibers was conducted by studying the photodegradation of methyl orange. The Pc decorated nanofibers were found to be more effective photocatalysts than the bare ones with the phthalocyanine TiO2 nanofibers being the best. The degradation kinetics were found to follow pseudo first order kinetics and obeyed the Langmuir Hinshelwood model. The nanocatalysts reported herein are therefore feasible candidates for real-life water purification applications.
Full Text:
Date Issued: 2020

Quick View

A narrative study of students’ and staff’s experiences of living with HIV and AIDS at Rhodes University

- Tsope, Lindiwe

Authors: Tsope, Lindiwe
Date: 2021-04
Subjects: AIDS (Disease) South Africa Makhanda , HIV infections South Africa Makhanda , College students Health and hygiene South Africa Makhanda , Universities and colleges South Africa Makhanda Employees Health and hygiene , Stigma (Social psychology) , AIDS (Disease) Social aspects South Africa Makhanda , HIV infections Social aspects South Africa Makhanda , AIDS (Disease) Psychological aspects , HIV infections Psychological aspects , Health counseling South Africa Makhanda , Discourse analysis, Narrative
Language: English
Type: thesis , text , Doctoral , PhD
Identifier: http://hdl.handle.net/10962/176894 , vital:42769 , 10.21504/10962/176894
Description: A narrative study of students’ and staff’s experiences of living with HIV and AIDS at Rhodes University Research on HIV and AIDS in university settings, especially research exploring the experience of living with the disease, has been minimal. As a response to the knowledge and research gaps, this thesis is a qualitative study involving students and staff living with HIV (LWH) and accessing treatment (ART) at the Rhodes University Health Care Centre. This study explored the personal and social symbolisms as well as meanings attached to living with HIV, through in-depth interviews with ten students and staff living with HIV, all purposively sampled and recruited through the Rhodes University Health Care Centre. Using social constructionism, symbolic interactionism and the theory of biographical disruption, the narratives revealed a positive and inspirational side of living with HIV and AIDS – especially emphasizing that PLWHA do not have to surrender to the deadly narrative of the disease. It became evident that stigma, both internal and external, largely influences illness narratives. Furthermore, the study revealed the social reconstruction of life narratives both in order to understand the illness in terms of past social experiences and to reaffirm the impression that life has a course and the self has a purpose. All participants found that accessing treatment from the Rhodes University Health Care Centre positively influenced their experiences of adherence and reconstruction of narratives. The study indicates that HIV-related interventions in place at the university need to pay more attention to the psychosocial needs of PLWH, involvement of PWLH, as well as keeping up with the continuously changing global HIV narrative. The study argues for more attention to in-depth experiences and personal narratives in HIV and AIDS, and PLWHA education at Rhodes University. , Thesis (PhD) -- Humanities, Department of Sociology, 2021
Full Text:
Date Issued: 2021-04

Quick View

Green synthesis of antimicrobial silver nanoparticles using aqueous leaf extracts from three Congolese plant species (Brillantaisia patula, Crossopteryx febrifuga and Senna siamea)

- Kambale, Espoir K, Nkanga, Christian I, Mutonkole, Blaise-Pascal I, Bapolisi, Alain M, Tassa, Daniel O, Liesse, Jean-Marie I, Krause, Rui W M, Memvanga, Patrick B

Authors: Kambale, Espoir K , Nkanga, Christian I , Mutonkole, Blaise-Pascal I , Bapolisi, Alain M , Tassa, Daniel O , Liesse, Jean-Marie I , Krause, Rui W M , Memvanga, Patrick B
Date: 2020
Subjects: To be catalogued
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/193419 , vital:45330 , xlink:href="https://doi.org/10.1016/j.heliyon.2020.e04493"
Description: In the present study, silver nanoparticles (AgNPs) were synthesized using aqueous leaf extracts of three Congolese plant species, namely Brillantaisia patula (BR-PA), Crossopteryx febrifuga (CR-FE) and Senna siamea (SE-SI). The obtained AgNPs were studied for their optical, structural, surface morphological and antibacterial properties. The prepared AgNPs were characterized by using UV-Visible spectra, Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray spectroscopy (EDX) and X-ray diffractometer (XRD). The synthesized nanoparticles were spherical shaped and well-dispersed with average sizes ranging from 45 to 110 nm. The AgNPs derived from BR-PA, CR-FE and SE-SI exhibited higher antibacterial activity against three bacterial pathogens of the human skin compared to their respective crude extracts and AgNO3. This indicated that the biomolecules covering the nanoparticles may enhance the biological activity of metal nanoparticles. Hence, our results support that biogenic synthesis of AgNPs from Congolese plants constitutes a potential area of interest for the therapeutic management of microbial diseases such as infectious skin diseases.
Full Text:
Date Issued: 2020

Quick View

Climate responsive innovation within the agricultural curriculum and learning system

- van Staden, Wilma

Authors: van Staden, Wilma
Date: 2020
Subjects: To be catalogued
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/389744 , vital:68479 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/186598"
Description: The purpose of this paper is to outline the climate responsive innovation process within the agricultural innovation system of the North West Province, South Africa. The focus was on the embedded curriculum and learning activity system and its responses to social-ecological and earth system changes influenced by climate change. It outlines the barriers and processes hampering curriculum and learning innovations towards climate-smart responsiveness, and also examines the processes required to initiate micro and macro innovations. This paper focusses on how actors within the system can initiate curriculum innovation and climate responsiveness through micro innovations when supported and how this can lead to macro innovations. The system experienced various barriers during the innovation process and overcame many challenges during the journey towards climate-smart responsiveness through the identification of contradictions within the system, developing tools to assist in the transitioning process and expansion in the social-spatial dimension by establishing a learning network within the surrounding communities. The research indicated that the catalysing of the curriculum and learning system required specific tools, time and the understanding of the importance of micro-level innovation.
Full Text:
Date Issued: 2020

Quick View

Long Waves of Strikes in South Africa: 1886–2019

- Cottle, Eddie

Authors: Cottle, Eddie
Date: 2020
Subjects: Strikes and lockouts South Africa , Long waves (Economics) South Africa , Business cycles South Africa , Industrial mobilization South Africa , Collective bargaining South Africa , Institutionalisation , Labor unions South Africa
Language: English
Type: thesis , text , Doctoral , PhD
Identifier: http://hdl.handle.net/10962/163228 , vital:41020 , doi:10.21504/10962/163228
Description: Thesis (PhD)--Rhodes University, Faculty of Humanities, Institute for Social and Economic Research (ISER), 2020.
Full Text:
Date Issued: 2020

Quick View

Improved Stability of Rifampicin in the Presence of Gastric-Resistant Isoniazid Microspheres in Acidic Media

- Mwila, Chiluba, Walker, Roderick B

Authors: Mwila, Chiluba , Walker, Roderick B
Date: 2020
Subjects: To be catalogued
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/183210 , vital:43929 , xlink:href="https://doi.org/10.3390/pharmaceutics12030234"
Description: The degradation of rifampicin (RIF) in an acidic medium to form 3-formyl rifamycin SV, a poorly absorbed compound, is accelerated in the presence of isoniazid, contributing to the poor bioavailability of rifampicin. This manuscript presents a novel approach in which isoniazid is formulated into gastric-resistant sustained-release microspheres and RIF into microporous floating sustained-release microspheres to reduce the potential for interaction between RIF and isoniazid (INH) in an acidic environment. Hydroxypropyl methylcellulose acetate succinate and Eudragit® L100 polymers were used for the manufacture of isoniazid-loaded gastric-resistant sustained-release microspheres using an o/o solvent emulsification evaporation approach. Microporous floating sustained-release microspheres for the delivery of rifampicin in the stomach were manufactured using emulsification and a diffusion/evaporation process. The design of experiments was used to evaluate the impact of input variables on predefined responses or quality attributes of the microspheres. The percent degradation of rifampicin following 12 h dissolution testing in 0.1 M HCl pH 1.2 in the presence of isoniazid gastric-resistant sustained-release microspheres was only 4.44%. These results indicate that the degradation of rifampicin in the presence of isoniazid in acidic media can be reduced by encapsulation of both active pharmaceutical ingredients to ensure release in different segments of the gastrointestinal tract, potentially improving the bioavailability of rifampicin.
Full Text:
Date Issued: 2020

Quick View

Paul Ashwin Transforming university education, a manifesto: A review

- McKenna, Sioux

Authors: McKenna, Sioux
Date: 2020
Subjects: To be catalogued
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/185886 , vital:44445 , xlink:href="https://doi.org/10.1007/s10734-020-00641-z"
Description: This book is wide-ranging in its focus. It tackles student-centeredness, graduate premiums, credentialing, quality assurance, big data and rankings, and yet it offers a coherent engagement with these and many other contemporary issues. The coherence is brought about by the consistent application of one central idea throughout the book. That is that the value of higher education for both the individual and for society is that it brings the graduate into a transformational relationship with knowledge that changes their sense of who they are and thereby makes possible their doing all number of things in the world.
Full Text:
Date Issued: 2020

Showing items 101 - 120 of 184