A comparative analysis of the rights of the child with particular reference to child soldiers
- Authors: Anwo, Joel Olasunkanmi
- Date: 2008
- Subjects: Children's rights -- Child welfare -- Demobilization of children , Disarmament -- Reintegration
- Language: English
- Type: Thesis , Doctoral , LLD
- Identifier: vital:11108 , http://hdl.handle.net/10353/102 , Children's rights -- Child welfare -- Demobilization of children , Disarmament -- Reintegration
- Description: The recruitment, enlistment and forceful conscription of children as soldiers is a cause for grave concern all over the world and most especially in Africa, where years of factional fighting, civil wars and cross border conflicts have raged, children and youth have been pulled into violence not only as victims, but also as perpetrators. The involvement of children in war posses a severe challenge to prevailing moral and legal norms of the conduct of modern warfare. A major problem and most controversial issue, among others, is on the age at which children should be eligible to become combatants. Children, who may be viewed as a valuable resource due to their often inherent malleability, wish to avenge family member(s) killed in war, sense of immunity to danger, and or feeling of power in participating in the violence. Can the use of children as soldiers be effectively regulated in Africa? All efforts to assist child soldiers in recovering from the devastating effects of wars often unwillingly helped promote the growing number of child soldiers. This is in part because wars are now more fought internally among rebel armies and factions vying for power with the government and thus enlist children into their various armies. The study comes to a conclusion that drastic steps need to be taken to ameliorate this unfortunate situation. This formed the basis of the recommendations offered in the thesis to assist the African continent.
- Full Text:
- Date Issued: 2008
- Authors: Anwo, Joel Olasunkanmi
- Date: 2008
- Subjects: Children's rights -- Child welfare -- Demobilization of children , Disarmament -- Reintegration
- Language: English
- Type: Thesis , Doctoral , LLD
- Identifier: vital:11108 , http://hdl.handle.net/10353/102 , Children's rights -- Child welfare -- Demobilization of children , Disarmament -- Reintegration
- Description: The recruitment, enlistment and forceful conscription of children as soldiers is a cause for grave concern all over the world and most especially in Africa, where years of factional fighting, civil wars and cross border conflicts have raged, children and youth have been pulled into violence not only as victims, but also as perpetrators. The involvement of children in war posses a severe challenge to prevailing moral and legal norms of the conduct of modern warfare. A major problem and most controversial issue, among others, is on the age at which children should be eligible to become combatants. Children, who may be viewed as a valuable resource due to their often inherent malleability, wish to avenge family member(s) killed in war, sense of immunity to danger, and or feeling of power in participating in the violence. Can the use of children as soldiers be effectively regulated in Africa? All efforts to assist child soldiers in recovering from the devastating effects of wars often unwillingly helped promote the growing number of child soldiers. This is in part because wars are now more fought internally among rebel armies and factions vying for power with the government and thus enlist children into their various armies. The study comes to a conclusion that drastic steps need to be taken to ameliorate this unfortunate situation. This formed the basis of the recommendations offered in the thesis to assist the African continent.
- Full Text:
- Date Issued: 2008
The development of sustainability ratios for public listed companies
- Authors: Anywar, Apio Dorcas
- Date: 2019
- Subjects: Business enterprises -- Finance
- Language: English
- Type: Thesis , Doctoral , DBA
- Identifier: http://hdl.handle.net/10948/40229 , vital:35991
- Description: Financial analysis is important when assessing a business’ financial as well as economic performance, and ratios are among the best known and most widely - used tools for financial analysis. Ratios act as a benchmarking and trend analysis tool by disclosing relationships as well as bases of comparison that reveal conditions and trends that cannot be detected by the individual components of the ratio. In addition, there is a need to measure sustainability performance as sustainability aims to radically transform how businesses understand and create value. Measuring sustainability performance can determine whether a business is moving in the right direction. This study developed a proposed set of sustainability ratios that could be used to determine the efficient and effective sustainability performance of public listed companies in South Africa. The study used a mixed methods research approach in three phases consisting of ten steps. In Phase 1 (Step 1), a secondary research in the form of a literature review was conducted. The critically evaluated secondary literature sources were used to create a theoretical framework of sustainability ratios and a ‘schedule for content analyses. In Phase 2 (Steps 2, 3, 4, 5), a quantitative content analysis of sustainability reports of FTSE/JSE Responsible Investment Top 30 Index companies was performed to obtain the variables that were used to calculate the sustainability ratios in the theoretical framework. It also identified additional sustainability ratios that were used by companies in practice, but that were not included in the theoretical framework of sustainability ratios. The sustainability ratios from the theoretical framework were calculated using the variables collected from the sustainability reports. Thereafter, descriptive statistical techniques were used to analyse the results. Lastly, in Phase 3 (Steps 6, 7, 8, 9), qualitative criteria were used to test the variables for the sustainability ratios that could not be calculated and to select the ratios from those calculated, reported and tested to be included in the proposed set of sustainability ratios. The purpose of Phase 3 was to test the usability, relevance, measurability, understandability and comparability of the sustainability ratios proposed in the theoretical framework as well as the sustainability ratios that were applied in the content of sustainability reports in South Africa. Step 10 represented the outcome of the study, a set of sustainability ratios was proposed. A set of 101 sustainability ratios were proposed. The proposed set of sustainability ratios linked the different sustainability issues to financial results by classifying them into four main categories, namely, (i) sustainable operational efficiency and effectiveness ratios (SOEE), (ii) sustainable risk - minimisation ratios (SRM), (iii) sustainable reputation – brand value ratios (SRBV) and (iv) sustainable innovation ratios (SI). These sustainability ratios could be used to assess the efficiency and effectiveness of a business’ sustainability strategies, its risk minimisation strategies, innovative capacities and reputation as well as brand value enhancing strategies. As the concern for business sustainability increases, the proposed sustainability ratios might satisfy the concerns of customers and stakeholders. These proposed ratios could also be refined in the future.
- Full Text:
- Date Issued: 2019
- Authors: Anywar, Apio Dorcas
- Date: 2019
- Subjects: Business enterprises -- Finance
- Language: English
- Type: Thesis , Doctoral , DBA
- Identifier: http://hdl.handle.net/10948/40229 , vital:35991
- Description: Financial analysis is important when assessing a business’ financial as well as economic performance, and ratios are among the best known and most widely - used tools for financial analysis. Ratios act as a benchmarking and trend analysis tool by disclosing relationships as well as bases of comparison that reveal conditions and trends that cannot be detected by the individual components of the ratio. In addition, there is a need to measure sustainability performance as sustainability aims to radically transform how businesses understand and create value. Measuring sustainability performance can determine whether a business is moving in the right direction. This study developed a proposed set of sustainability ratios that could be used to determine the efficient and effective sustainability performance of public listed companies in South Africa. The study used a mixed methods research approach in three phases consisting of ten steps. In Phase 1 (Step 1), a secondary research in the form of a literature review was conducted. The critically evaluated secondary literature sources were used to create a theoretical framework of sustainability ratios and a ‘schedule for content analyses. In Phase 2 (Steps 2, 3, 4, 5), a quantitative content analysis of sustainability reports of FTSE/JSE Responsible Investment Top 30 Index companies was performed to obtain the variables that were used to calculate the sustainability ratios in the theoretical framework. It also identified additional sustainability ratios that were used by companies in practice, but that were not included in the theoretical framework of sustainability ratios. The sustainability ratios from the theoretical framework were calculated using the variables collected from the sustainability reports. Thereafter, descriptive statistical techniques were used to analyse the results. Lastly, in Phase 3 (Steps 6, 7, 8, 9), qualitative criteria were used to test the variables for the sustainability ratios that could not be calculated and to select the ratios from those calculated, reported and tested to be included in the proposed set of sustainability ratios. The purpose of Phase 3 was to test the usability, relevance, measurability, understandability and comparability of the sustainability ratios proposed in the theoretical framework as well as the sustainability ratios that were applied in the content of sustainability reports in South Africa. Step 10 represented the outcome of the study, a set of sustainability ratios was proposed. A set of 101 sustainability ratios were proposed. The proposed set of sustainability ratios linked the different sustainability issues to financial results by classifying them into four main categories, namely, (i) sustainable operational efficiency and effectiveness ratios (SOEE), (ii) sustainable risk - minimisation ratios (SRM), (iii) sustainable reputation – brand value ratios (SRBV) and (iv) sustainable innovation ratios (SI). These sustainability ratios could be used to assess the efficiency and effectiveness of a business’ sustainability strategies, its risk minimisation strategies, innovative capacities and reputation as well as brand value enhancing strategies. As the concern for business sustainability increases, the proposed sustainability ratios might satisfy the concerns of customers and stakeholders. These proposed ratios could also be refined in the future.
- Full Text:
- Date Issued: 2019
The intersection between social development and the internationalisation of higher education in Colombia
- Authors: Anzola-Pardo, Giovanni
- Date: 2018
- Subjects: Education, Higher -- Colombia , Education and globalization International education -- Colombia Education, Higher -- International cooperation -- Colombia
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/23371 , vital:30536
- Description: The study addresses the nature of Colombian sustainable social development and the internationalisation of higher education (iHE). This intersection is analysed within various theoretical paradigms surrounding social sustainable development and the internationalisation of higher education. This study aims at reviewing the activities of Higher Education Institutions (HEIs) which focus on internationalisation. The analysis focuses on the manner in which HEIs in Colombia approach internationalisation vis-à-vis social sustainable development, and emphasis is made on knowledge transfer, research and community engagement. Using the theories of sustainable development, the iHE, in terms of practises and policies, are assessed. Within a mixed-methods approach, data gathered from Colombian university heads (16 presidents and vice-presidents) and 133 individuals responsible for internationalisation affairs is analysed. Concurrent triangulation is used to help introduce a series of themes and sub-themes derived from the qualitative and quantitative information. Within a social constructionist framework, this study has a twofold purpose. On the one hand, it is sought to identify and understand the challenges for Colombia’s academic internationalisation; on the other, an in-depth approach is presented in relation to the way different stakeholders perceive the society-HE internationalisation nexus. The major findings of the study indicate that there is a need to clarify and revise Colombia’s Higher Education policy to address both the education needs of the society and its social development requirements. It was also found that higher education internationalisation could act as an important agent of social change.
- Full Text:
- Date Issued: 2018
- Authors: Anzola-Pardo, Giovanni
- Date: 2018
- Subjects: Education, Higher -- Colombia , Education and globalization International education -- Colombia Education, Higher -- International cooperation -- Colombia
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/23371 , vital:30536
- Description: The study addresses the nature of Colombian sustainable social development and the internationalisation of higher education (iHE). This intersection is analysed within various theoretical paradigms surrounding social sustainable development and the internationalisation of higher education. This study aims at reviewing the activities of Higher Education Institutions (HEIs) which focus on internationalisation. The analysis focuses on the manner in which HEIs in Colombia approach internationalisation vis-à-vis social sustainable development, and emphasis is made on knowledge transfer, research and community engagement. Using the theories of sustainable development, the iHE, in terms of practises and policies, are assessed. Within a mixed-methods approach, data gathered from Colombian university heads (16 presidents and vice-presidents) and 133 individuals responsible for internationalisation affairs is analysed. Concurrent triangulation is used to help introduce a series of themes and sub-themes derived from the qualitative and quantitative information. Within a social constructionist framework, this study has a twofold purpose. On the one hand, it is sought to identify and understand the challenges for Colombia’s academic internationalisation; on the other, an in-depth approach is presented in relation to the way different stakeholders perceive the society-HE internationalisation nexus. The major findings of the study indicate that there is a need to clarify and revise Colombia’s Higher Education policy to address both the education needs of the society and its social development requirements. It was also found that higher education internationalisation could act as an important agent of social change.
- Full Text:
- Date Issued: 2018
Evaluation of antidiarrhoeal and toxicological properties of Hermannia Incana cav.: a South African medicinal plant
- Authors: Appidi, Jaipal Reddy
- Date: 2010
- Subjects: Sterculiaceae , Medicinal plants -- South Africa -- Eastern Cape , Diarrhea , Botany, Medical
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:11304 , http://hdl.handle.net/10353/259 , Sterculiaceae , Medicinal plants -- South Africa -- Eastern Cape , Diarrhea , Botany, Medical
- Description: Hermannia incana Cav. (Sterculiaceae), known as sweet yellow bells, is a medicinal plant used by the people of the Eastern Cape for the treatment of stomach-ache and diarrhoea. It has purgative and diaphoretic effects. It is a prostrate herb with yellow flowers and sparsely hairy and slightly glandular leaves, occurring in grassland and marshes in the Eastern Cape Province of South Africa. Based on the ethnomedical uses of this plant, the research project was designed to evaluate its antidiarrhoeal and toxicological properties. An ethnobotanical study of plants used for the treatment of diarrhoea in the Eastern Cape Province was carried out, using a questionnaire which was administered to herbalists, traditional healers and rural dwellers. This survey indicated a total of 17 plant species from 14 families. Elephantorrhiza elephantine (Burch.) Skeels, Hermannia incana Cav., Pelargonium reniforme Curt., Alepidea amatymbica Eckl. & Zeyh. and Bulbine latifolia (L.f.) Roem. et Schult. were the most frequently mentioned and highly recommended plants for the treatment of diarrhoea by both the traditional healers and rural dwellers. The root, bark and leaves are the common parts of plants used, while decoctions and infusions are the main methods of preparation. The agar dilution method was used to study the antimicrobial activity. The methanol extracts of the plant showed appreciable activity against Gram-positive and Gram-negative bacteria at concentrations ranging from 0.5 to 7.0 mg/ml. The acetone and water extracts of both the leaves and the roots showed moderate activity against Gram positive bacteria and less activity against Gram negative bacteria. All the extracts inhibited the growth of the fungi Aspergillus flavus, Aspergillus niger, and Mucor hiemalis with growth inhibition ranging from 54.31 percent to 96.67 percent at 0.1-10 mg/ml. None of the extracts suppressed the growth of Candida albicans at the maximum concentration (10 mg/ml) tested. iii In the in vivo antidiarrhoeal evaluation using Wistar rats, the aqueous extract at all the doses tested, significantly prolonged the time of induction of diarrhoea and also reduced the frequency of diarrhoeal episodes and fecal parameters (total number, number of wet, fresh and dry weight and water content of the faeces). The percentage inhibition of defecation and intestinal content (enteropooling) were increased in dose dependent manner. The doses also reduced the intestinal transit time of charcoal, masses and volumes of intestinal fluid (gastrointestinal motility). These results are indications of antidiarrhoeal property of H. incana leaf extract with the 600 mg/kg body weight of the extract being the most effective. In the toxicological evaluation using Wistar rats, the oral administration of the extract did not produce any significant effect on the liver and kidney body weight ratios, RBC, HB, PCV, MCV MCH, MCHC, RCDW, WBC, neutrophils, monocytes and basophils cholesterol, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and atherogenic index. The extract also did not affect the levels of sodium, potassium, chloride, inorganic phosphorus, urea, creatinine, total protein, globulin, albumin, total and conjugated bilirubin. The activities of alkaline phosphatase, gamma glutamyl transferase and alanine aminotransaminase in the serum were increased by the extract whereas aspartate aminotransaminase was decreased. The levels of LUC, platelets, lymphocytes and eosinophils were significantly affected at 600 mg/kg body weight. The available evidence in this study suggests that the extract of H. incana leaf is mild, parameter and dose specific. The structure and distribution of foliar appendages on the leaves of this plant were investigated with the JEOL (JSM-6390LV) scanning electron microscope (SEM). Both glandular and non-glandular trichomes were observed. Long stalked glandular trichomes were present on both the abaxial and adaxial surfaces while short stalked glandular trichomes were present only on the adaxial surface. Glandular trichomes were capitate while nonglandular trichomes were stellate with many arms. Energy dispersive X-ray spectroscopyiv SEM showed that Al, Ca, K, Na, Ti and Si were the major constituents of the crystals analyzed from the leaf surfaces. The phytochemical screening of H. incana revealed the presence of bioactive antidiarrhoeal agents such as alkaloids, tannins, saponins, phenolics, triterpenes, cardiac glycosides, flavonoids, cardenolides and dienolides. Two flavonoids, epicatechin and 3, 5, 7, 2’ tetra-hydroxy flavone-3- O--D-glucopyranoside were isolated from the leaves of the plant through bio-active guided fractionation. Both these compounds were screened against diarrhoea causative organisms (Echerichia coli, Shigella flexneri, Bacillus cereus and Staphylococcus aureus) and exhibiting minimum inhibitory concentrations ranging from 12.5 to 100 μg/ml. The findings from this research have generally justified the traditional use of this plant for the treatment of diarrhoea in this province.
- Full Text:
- Date Issued: 2010
- Authors: Appidi, Jaipal Reddy
- Date: 2010
- Subjects: Sterculiaceae , Medicinal plants -- South Africa -- Eastern Cape , Diarrhea , Botany, Medical
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:11304 , http://hdl.handle.net/10353/259 , Sterculiaceae , Medicinal plants -- South Africa -- Eastern Cape , Diarrhea , Botany, Medical
- Description: Hermannia incana Cav. (Sterculiaceae), known as sweet yellow bells, is a medicinal plant used by the people of the Eastern Cape for the treatment of stomach-ache and diarrhoea. It has purgative and diaphoretic effects. It is a prostrate herb with yellow flowers and sparsely hairy and slightly glandular leaves, occurring in grassland and marshes in the Eastern Cape Province of South Africa. Based on the ethnomedical uses of this plant, the research project was designed to evaluate its antidiarrhoeal and toxicological properties. An ethnobotanical study of plants used for the treatment of diarrhoea in the Eastern Cape Province was carried out, using a questionnaire which was administered to herbalists, traditional healers and rural dwellers. This survey indicated a total of 17 plant species from 14 families. Elephantorrhiza elephantine (Burch.) Skeels, Hermannia incana Cav., Pelargonium reniforme Curt., Alepidea amatymbica Eckl. & Zeyh. and Bulbine latifolia (L.f.) Roem. et Schult. were the most frequently mentioned and highly recommended plants for the treatment of diarrhoea by both the traditional healers and rural dwellers. The root, bark and leaves are the common parts of plants used, while decoctions and infusions are the main methods of preparation. The agar dilution method was used to study the antimicrobial activity. The methanol extracts of the plant showed appreciable activity against Gram-positive and Gram-negative bacteria at concentrations ranging from 0.5 to 7.0 mg/ml. The acetone and water extracts of both the leaves and the roots showed moderate activity against Gram positive bacteria and less activity against Gram negative bacteria. All the extracts inhibited the growth of the fungi Aspergillus flavus, Aspergillus niger, and Mucor hiemalis with growth inhibition ranging from 54.31 percent to 96.67 percent at 0.1-10 mg/ml. None of the extracts suppressed the growth of Candida albicans at the maximum concentration (10 mg/ml) tested. iii In the in vivo antidiarrhoeal evaluation using Wistar rats, the aqueous extract at all the doses tested, significantly prolonged the time of induction of diarrhoea and also reduced the frequency of diarrhoeal episodes and fecal parameters (total number, number of wet, fresh and dry weight and water content of the faeces). The percentage inhibition of defecation and intestinal content (enteropooling) were increased in dose dependent manner. The doses also reduced the intestinal transit time of charcoal, masses and volumes of intestinal fluid (gastrointestinal motility). These results are indications of antidiarrhoeal property of H. incana leaf extract with the 600 mg/kg body weight of the extract being the most effective. In the toxicological evaluation using Wistar rats, the oral administration of the extract did not produce any significant effect on the liver and kidney body weight ratios, RBC, HB, PCV, MCV MCH, MCHC, RCDW, WBC, neutrophils, monocytes and basophils cholesterol, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and atherogenic index. The extract also did not affect the levels of sodium, potassium, chloride, inorganic phosphorus, urea, creatinine, total protein, globulin, albumin, total and conjugated bilirubin. The activities of alkaline phosphatase, gamma glutamyl transferase and alanine aminotransaminase in the serum were increased by the extract whereas aspartate aminotransaminase was decreased. The levels of LUC, platelets, lymphocytes and eosinophils were significantly affected at 600 mg/kg body weight. The available evidence in this study suggests that the extract of H. incana leaf is mild, parameter and dose specific. The structure and distribution of foliar appendages on the leaves of this plant were investigated with the JEOL (JSM-6390LV) scanning electron microscope (SEM). Both glandular and non-glandular trichomes were observed. Long stalked glandular trichomes were present on both the abaxial and adaxial surfaces while short stalked glandular trichomes were present only on the adaxial surface. Glandular trichomes were capitate while nonglandular trichomes were stellate with many arms. Energy dispersive X-ray spectroscopyiv SEM showed that Al, Ca, K, Na, Ti and Si were the major constituents of the crystals analyzed from the leaf surfaces. The phytochemical screening of H. incana revealed the presence of bioactive antidiarrhoeal agents such as alkaloids, tannins, saponins, phenolics, triterpenes, cardiac glycosides, flavonoids, cardenolides and dienolides. Two flavonoids, epicatechin and 3, 5, 7, 2’ tetra-hydroxy flavone-3- O--D-glucopyranoside were isolated from the leaves of the plant through bio-active guided fractionation. Both these compounds were screened against diarrhoea causative organisms (Echerichia coli, Shigella flexneri, Bacillus cereus and Staphylococcus aureus) and exhibiting minimum inhibitory concentrations ranging from 12.5 to 100 μg/ml. The findings from this research have generally justified the traditional use of this plant for the treatment of diarrhoea in this province.
- Full Text:
- Date Issued: 2010
A psychobiographical case study: Amelia Dyer in a search for glory
- Authors: April, Heather
- Date: 2020
- Subjects: Serial murderers--Psychology
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50857 , vital:43008
- Description: The study is a psychobiographical case study based on the life of a Victorian baby farmer Amelia Dyer (1837-1896). She was executed for the murder of babies who were placed in her care over a period of 30 years. Psychobiography is a qualitative method of enquiry which explores the life of a unique individual subject through the lens of a psychological theory for the purpose of creating a coherent psychological case study. The psychoanalytic theoretical lens of Karen Horney was used to trace the evolution of Amelia Dyer’s sense of self within the Victorian culture of respectability. Baby farming referred to an unregulated business of adoption and fostering of infants, mostly illegitimate infants for a fee. Insufficient social structures and support for unwed mothers and children encouraged the business practice as women had very little choice for childcare. Baby farming was open to abuse and exploitation and hundreds of babies lost their lives due to insufficient care or infanticide. Amelia Dyer showed special talents and creativity from a young age, was ambitious and wanted to be self-reliant in a culture that did not provide women with opportunities to live out their ambitions. Baby farming became a business venture for her in the early stages of her life which later evolved into sadistic abuse and murder of the infants. Her evolution from a creative and hardworking young girl to a sadistic murderer of children is what qualifies her as a suitable subject for the exploration of Karen Horney’s dynamic theory of neuroses and the development of the neurotic self within culture. Extensive biographical data was collected and processed into salient themes. The study integrates the theory of Karen Horney, the life experiences of Amelia Dyer and Victorian respectability and demonstrates the value of using psychobiography as the method of inquiry into the exploration of the unique individual. The findings of the study demonstrated that Amelia Dyer and her social context were inextricably bound by a vicious cycle of psychic and emotional vi conflicts related to fear, control and self-hatred by the internalization of gender stereotypes and norms. The contribution of the study as a whole rests with its demonstration of the value of a holistic and reflexive exploration of the unique individual woman. It demonstrates the value of Horney’s in-depth theoretical understanding of the ambivalent core of selfhood that lies behind observable acts of behavior. The study as a whole contributes towards building upon holistic and integrative therapeutic frameworks in the understanding of diversity amongst women and mothers in culture.
- Full Text:
- Date Issued: 2020
- Authors: April, Heather
- Date: 2020
- Subjects: Serial murderers--Psychology
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50857 , vital:43008
- Description: The study is a psychobiographical case study based on the life of a Victorian baby farmer Amelia Dyer (1837-1896). She was executed for the murder of babies who were placed in her care over a period of 30 years. Psychobiography is a qualitative method of enquiry which explores the life of a unique individual subject through the lens of a psychological theory for the purpose of creating a coherent psychological case study. The psychoanalytic theoretical lens of Karen Horney was used to trace the evolution of Amelia Dyer’s sense of self within the Victorian culture of respectability. Baby farming referred to an unregulated business of adoption and fostering of infants, mostly illegitimate infants for a fee. Insufficient social structures and support for unwed mothers and children encouraged the business practice as women had very little choice for childcare. Baby farming was open to abuse and exploitation and hundreds of babies lost their lives due to insufficient care or infanticide. Amelia Dyer showed special talents and creativity from a young age, was ambitious and wanted to be self-reliant in a culture that did not provide women with opportunities to live out their ambitions. Baby farming became a business venture for her in the early stages of her life which later evolved into sadistic abuse and murder of the infants. Her evolution from a creative and hardworking young girl to a sadistic murderer of children is what qualifies her as a suitable subject for the exploration of Karen Horney’s dynamic theory of neuroses and the development of the neurotic self within culture. Extensive biographical data was collected and processed into salient themes. The study integrates the theory of Karen Horney, the life experiences of Amelia Dyer and Victorian respectability and demonstrates the value of using psychobiography as the method of inquiry into the exploration of the unique individual. The findings of the study demonstrated that Amelia Dyer and her social context were inextricably bound by a vicious cycle of psychic and emotional vi conflicts related to fear, control and self-hatred by the internalization of gender stereotypes and norms. The contribution of the study as a whole rests with its demonstration of the value of a holistic and reflexive exploration of the unique individual woman. It demonstrates the value of Horney’s in-depth theoretical understanding of the ambivalent core of selfhood that lies behind observable acts of behavior. The study as a whole contributes towards building upon holistic and integrative therapeutic frameworks in the understanding of diversity amongst women and mothers in culture.
- Full Text:
- Date Issued: 2020
An investigation into the taxonomy of the diatoms (Bacillariophyta) of the Sundays and Great Fish Rivers, with ecological observations on the Sundays River
- Archibald, Robert Eldred Mostert
- Authors: Archibald, Robert Eldred Mostert
- Date: 1982
- Subjects: Diatoms -- South Africa -- Eastern Cape Diatoms -- Classification Aquatic ecology -- South Africa -- Eastern Cape -- Sundays River
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4180 , http://hdl.handle.net/10962/d1003728
- Description: This report on the diatoms (Bacillariophyta) of the Sundays and Great Fish rivers is divided into two sections. In Volume 1 the taxonomy of the diatoms from these two river systems is examined. A total of 331 taxa were studied, of which 5 are described as new species. Two taxa are given new names, since they were previously known under later homonyms. Twenty seven taxa were recorded for the first time from South Africa, while a number of species are given amended descriptions in the light of fresh information obtained concerning them. A few taxa (chiefly South African forms) have been united with previously described taxa. For the remainder of the taxa mentioned in the text, comments are passed with regard to their taxonomy and dimensions, based on facts gained through literature surveys and personal observations of the relevant taxa. As far as possible all taxa examined in Volume 1 are illustrated, and these illustrations are presented in Volume 3 of this study. Volume 2 deals with the ecology of the diatoms in the Sundays River. Special emphasis is laid on relating the composition of the diatom associations at the selected stations to the ambient salinity and ionic composition of the water. A new index, the Salinity Tolerance Index (STI), is proposed to summarize by means of a numerical value the information obtained from the analysis of a diatom association with respect to the character of the component taxa, and to indicate whether the association is derived from a freshwater, brackish water or marine source. The efficacy of the STI is evaluated in the text. The effect of the geological formations of the Sundays River valley and the underground waters emanating from them is discussed in the text. The consequences of a severe drought in the lower Sundays River, including hypersaline water in the upper estuary, on the diatom flora are also investigated.
- Full Text:
- Date Issued: 1982
- Authors: Archibald, Robert Eldred Mostert
- Date: 1982
- Subjects: Diatoms -- South Africa -- Eastern Cape Diatoms -- Classification Aquatic ecology -- South Africa -- Eastern Cape -- Sundays River
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4180 , http://hdl.handle.net/10962/d1003728
- Description: This report on the diatoms (Bacillariophyta) of the Sundays and Great Fish rivers is divided into two sections. In Volume 1 the taxonomy of the diatoms from these two river systems is examined. A total of 331 taxa were studied, of which 5 are described as new species. Two taxa are given new names, since they were previously known under later homonyms. Twenty seven taxa were recorded for the first time from South Africa, while a number of species are given amended descriptions in the light of fresh information obtained concerning them. A few taxa (chiefly South African forms) have been united with previously described taxa. For the remainder of the taxa mentioned in the text, comments are passed with regard to their taxonomy and dimensions, based on facts gained through literature surveys and personal observations of the relevant taxa. As far as possible all taxa examined in Volume 1 are illustrated, and these illustrations are presented in Volume 3 of this study. Volume 2 deals with the ecology of the diatoms in the Sundays River. Special emphasis is laid on relating the composition of the diatom associations at the selected stations to the ambient salinity and ionic composition of the water. A new index, the Salinity Tolerance Index (STI), is proposed to summarize by means of a numerical value the information obtained from the analysis of a diatom association with respect to the character of the component taxa, and to indicate whether the association is derived from a freshwater, brackish water or marine source. The efficacy of the STI is evaluated in the text. The effect of the geological formations of the Sundays River valley and the underground waters emanating from them is discussed in the text. The consequences of a severe drought in the lower Sundays River, including hypersaline water in the upper estuary, on the diatom flora are also investigated.
- Full Text:
- Date Issued: 1982
An investigation into the introduction of a new wealth tax in South Africa
- Authors: Arendse, Jacqueline A
- Date: 2018
- Subjects: Wealth tax -- Law and legislation -- South Africa , Taxation -- Law and legislation -- South Africa , Income tax -- South Africa , Fiscal policy -- South Africa , South Africa -- Economic conditions , Income distribution -- South Africa
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/61379 , vital:28020
- Description: In a world of economic uncertainty and manifold social problems, South Africa has its own unique challenges of low economic growth, persistent budget deficits that produce increasing government debt and the highest level of economic inequality in the world. The history of injustice and economic marginalisation and the failure of the economy to provide inclusive growth drives an urgent need to address economic inequality through tax policy, placing ever more focus on wealth taxes as a possible solution. There is a hope is that taxing the wealthy may provide the opportunity to redistribute desperately-needed resources to those denied the opportunity to build wealth and who are trapped in the cycle of poverty. Yet, as appealing as a new wealth tax may seem, the introduction of such a tax carries with it a range of risks, not all of which are known. Of great concern is the possible effect on the economy, which, in its vulnerable state, cannot afford any loss of capital and investment. Very little research has been done on wealth tax in the South African context and there is a dearth of literature focusing on the views and perceptions of the wealthy individuals themselves. This qualitative study investigates the merits and disadvantages of a new wealth tax and seeks to identify any unintended consequences that could result from the implementation of a new wealth tax in South Africa, drawing from historical and international experience and primary data obtained from interviews with individuals likely to be affected by such a tax. Having explored the literature and international experiences with wealth tax and having probed the thinking of wealthy individuals who would be the payers of a wealth tax, the study finds that a new wealth tax may contribute towards the progressivity of the tax system, but it is doubtful whether such a tax would provide a sustainable revenue stream that would be sufficient to address economic inequality and there is a risk of causing harm to the economy. Recognising that the motivation for wealth taxes is often driven more by political argument and public perception than by rational quantitative analysis, the study also anticipates the introduction of a new wealth tax and suggests guidelines for the design of such a tax within the framework for evaluating a good tax system. This study informs the debate on wealth taxes in South Africa and contributes to the design of such a tax, should it be implemented.
- Full Text:
- Date Issued: 2018
- Authors: Arendse, Jacqueline A
- Date: 2018
- Subjects: Wealth tax -- Law and legislation -- South Africa , Taxation -- Law and legislation -- South Africa , Income tax -- South Africa , Fiscal policy -- South Africa , South Africa -- Economic conditions , Income distribution -- South Africa
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/61379 , vital:28020
- Description: In a world of economic uncertainty and manifold social problems, South Africa has its own unique challenges of low economic growth, persistent budget deficits that produce increasing government debt and the highest level of economic inequality in the world. The history of injustice and economic marginalisation and the failure of the economy to provide inclusive growth drives an urgent need to address economic inequality through tax policy, placing ever more focus on wealth taxes as a possible solution. There is a hope is that taxing the wealthy may provide the opportunity to redistribute desperately-needed resources to those denied the opportunity to build wealth and who are trapped in the cycle of poverty. Yet, as appealing as a new wealth tax may seem, the introduction of such a tax carries with it a range of risks, not all of which are known. Of great concern is the possible effect on the economy, which, in its vulnerable state, cannot afford any loss of capital and investment. Very little research has been done on wealth tax in the South African context and there is a dearth of literature focusing on the views and perceptions of the wealthy individuals themselves. This qualitative study investigates the merits and disadvantages of a new wealth tax and seeks to identify any unintended consequences that could result from the implementation of a new wealth tax in South Africa, drawing from historical and international experience and primary data obtained from interviews with individuals likely to be affected by such a tax. Having explored the literature and international experiences with wealth tax and having probed the thinking of wealthy individuals who would be the payers of a wealth tax, the study finds that a new wealth tax may contribute towards the progressivity of the tax system, but it is doubtful whether such a tax would provide a sustainable revenue stream that would be sufficient to address economic inequality and there is a risk of causing harm to the economy. Recognising that the motivation for wealth taxes is often driven more by political argument and public perception than by rational quantitative analysis, the study also anticipates the introduction of a new wealth tax and suggests guidelines for the design of such a tax within the framework for evaluating a good tax system. This study informs the debate on wealth taxes in South Africa and contributes to the design of such a tax, should it be implemented.
- Full Text:
- Date Issued: 2018
Performance, functionalism and form in Ịzọn oral poety
- Authors: Armstrong, Imomotimi
- Date: 2020
- Subjects: Ijo (African people , Ijo language , Folk poetry, Ijo , Folk poetry -- Nigeria
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/140641 , vital:37906
- Description: Since the publication of Ruth Finnegan’s influential Oral Literature in Africa, way back in 1970, scholars have been paying earnest attention to oral traditions on the African continent. That seminal book pointed out to Africanist scholars the need to urgently collect and document the oral literatures of their various ethnic groups before they die out. However, it is the verbal arts of the major ethnic groups on the continent that very often benefit from this collection and documentation, as it were. Therefore, this study sought to examine the oral poetry of the Ịzọn, a minority ethnic nationality, located in the oil-rich Niger Delta region of Nigeria. The study employed unstructured interviews and participant observations to collect the data for the research. The transcribed and translated data was examined through three eclectic theories to the study of folklore: Russian formalism, performance and functionalism. The study found out that Ịzọn oral poetry is a combination of songs and one person’s praise chants. Moreover, it revealed that praise chanting is a recent practice amongst the Ịzọn that was introduced into Ịzọnland by Chief Adolphus Munamuna from the Yoruba of southwestern Nigeria. Furthermore, the study established that oral poetry plays important roles amongst the people. Besides, it ascertained that the performance of some sub-categories of the poetry is highly dramatic and theatrical. It also discovered that stylistic techniques such as formula, parallelism, proverb, ideophone, praise title, metaphor, repetition, alliteration, assonance, vowel lengthening, amongst others, give the poetry the quality of “literariness.” In addition, the study found out that the poetry, like oral poetry in other ethnic groups, demonstrates the three qualities of change, adaptability and survival. The study has contributed to existing scholarship on African oral traditions in the sense of collecting, documenting and generating awareness on Ịzọn oral poetry, most importantly pointing out the existence of praise chanting amongst a people who had no such culture and the conditions that gave rise to that practice.
- Full Text:
- Date Issued: 2020
- Authors: Armstrong, Imomotimi
- Date: 2020
- Subjects: Ijo (African people , Ijo language , Folk poetry, Ijo , Folk poetry -- Nigeria
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/140641 , vital:37906
- Description: Since the publication of Ruth Finnegan’s influential Oral Literature in Africa, way back in 1970, scholars have been paying earnest attention to oral traditions on the African continent. That seminal book pointed out to Africanist scholars the need to urgently collect and document the oral literatures of their various ethnic groups before they die out. However, it is the verbal arts of the major ethnic groups on the continent that very often benefit from this collection and documentation, as it were. Therefore, this study sought to examine the oral poetry of the Ịzọn, a minority ethnic nationality, located in the oil-rich Niger Delta region of Nigeria. The study employed unstructured interviews and participant observations to collect the data for the research. The transcribed and translated data was examined through three eclectic theories to the study of folklore: Russian formalism, performance and functionalism. The study found out that Ịzọn oral poetry is a combination of songs and one person’s praise chants. Moreover, it revealed that praise chanting is a recent practice amongst the Ịzọn that was introduced into Ịzọnland by Chief Adolphus Munamuna from the Yoruba of southwestern Nigeria. Furthermore, the study established that oral poetry plays important roles amongst the people. Besides, it ascertained that the performance of some sub-categories of the poetry is highly dramatic and theatrical. It also discovered that stylistic techniques such as formula, parallelism, proverb, ideophone, praise title, metaphor, repetition, alliteration, assonance, vowel lengthening, amongst others, give the poetry the quality of “literariness.” In addition, the study found out that the poetry, like oral poetry in other ethnic groups, demonstrates the three qualities of change, adaptability and survival. The study has contributed to existing scholarship on African oral traditions in the sense of collecting, documenting and generating awareness on Ịzọn oral poetry, most importantly pointing out the existence of praise chanting amongst a people who had no such culture and the conditions that gave rise to that practice.
- Full Text:
- Date Issued: 2020
Learning to learn: a critical realist exploration into the home established learning practices of a marginalised community in Port Elizabeth
- Authors: Armstrong, Meredith
- Date: 2019
- Subjects: Minorities -- Education (Higher) -- South Africa , Readiness for school -- Social aspects -- South Africa , Inclusive education -- Social aspects -- South Africa , Marginality, Social -- South Africa , Critical realism
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/93778 , vital:30939
- Description: This study was completed as part of a project exploring social inclusion and exclusion in South African higher education. In a globalised world, the achievement of a qualification from an institution of higher education is increasingly key to finding any sort of employment. This is particularly the case in South Africa where employment amongst black citizens is inordinately high. The aim of the research reported upon in this thesis was to better understand the construct of ‘epistemological access’ (Morrow, 1992), often used in relation to the needs of black working class students entering higher education, in relation to performance data (see for example, CHE, 2016) that repeatedly shows that black students fare less well than their white peers. Following what might be termed a ‘social’ approach to understanding access, this study begins long before most students have even heard of higher education and focuses on identifying the mechanisms that come into play at much earlier level of learning and literacy development. The study outlines the development of ‘ways of being’, or social practices, surrounding learning in a marginalised community in Port Elizabeth, in the Eastern Cape, South Africa. This was achieved by means of critical ethnography and it is therefore qualitatively based. The study shows how social structures enable or constrain a child’s school readiness and how they then go on to support or impede progress in school where the language and literacy needed for educational success are further developed. The study therefore aims to allow us to explain global data indicating that the single greatest indicator of a young person’s ability to access and succeed in higher education is the level of education of caregivers in their homes of origin. Examined from a critical perspective (i.e. with a concern for social justice), this study has made use of a framework using social, psychological and linguistic theory and more, particularly, the work of sociologist Margaret Archer (1995, 1996, 2003). The study makes particular use of Archer’s ‘morphogenetic framework’ which allows for an analysis of the way structure and culture impact on a child’s development over time. As I was concerned that my own social status might impact on the understandings I developed as a critical ethnographer, the study acknowledges my own experiences of learning and the way my own family sought to enhance them as enabling. In doing this, the study aims to better contribute to understandings of social justice in South Africa.
- Full Text:
- Date Issued: 2019
- Authors: Armstrong, Meredith
- Date: 2019
- Subjects: Minorities -- Education (Higher) -- South Africa , Readiness for school -- Social aspects -- South Africa , Inclusive education -- Social aspects -- South Africa , Marginality, Social -- South Africa , Critical realism
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/93778 , vital:30939
- Description: This study was completed as part of a project exploring social inclusion and exclusion in South African higher education. In a globalised world, the achievement of a qualification from an institution of higher education is increasingly key to finding any sort of employment. This is particularly the case in South Africa where employment amongst black citizens is inordinately high. The aim of the research reported upon in this thesis was to better understand the construct of ‘epistemological access’ (Morrow, 1992), often used in relation to the needs of black working class students entering higher education, in relation to performance data (see for example, CHE, 2016) that repeatedly shows that black students fare less well than their white peers. Following what might be termed a ‘social’ approach to understanding access, this study begins long before most students have even heard of higher education and focuses on identifying the mechanisms that come into play at much earlier level of learning and literacy development. The study outlines the development of ‘ways of being’, or social practices, surrounding learning in a marginalised community in Port Elizabeth, in the Eastern Cape, South Africa. This was achieved by means of critical ethnography and it is therefore qualitatively based. The study shows how social structures enable or constrain a child’s school readiness and how they then go on to support or impede progress in school where the language and literacy needed for educational success are further developed. The study therefore aims to allow us to explain global data indicating that the single greatest indicator of a young person’s ability to access and succeed in higher education is the level of education of caregivers in their homes of origin. Examined from a critical perspective (i.e. with a concern for social justice), this study has made use of a framework using social, psychological and linguistic theory and more, particularly, the work of sociologist Margaret Archer (1995, 1996, 2003). The study makes particular use of Archer’s ‘morphogenetic framework’ which allows for an analysis of the way structure and culture impact on a child’s development over time. As I was concerned that my own social status might impact on the understandings I developed as a critical ethnographer, the study acknowledges my own experiences of learning and the way my own family sought to enhance them as enabling. In doing this, the study aims to better contribute to understandings of social justice in South Africa.
- Full Text:
- Date Issued: 2019
A comparative study of the language, mathematics and science literacy knowledge and skills of grade 9 learners in secondary schools in Port Elizabeth
- Authors: Arnolds, Keith Victor
- Date: 2012
- Subjects: Educational tests and measurements -- South Africa -- Port Elizabeth , Comparative education , Language and languages -- Study and teaching -- South Africa -- Port Elizabeth , Mathematics -- Study and teaching -- South Africa -- Port Elizabeth , Science -- Study and teaching -- South Africa -- Port Elizabeth , Education, Secondary -- South Africa -- Port Elizabeth
- Language: English
- Type: Thesis , Doctoral , DEd
- Identifier: vital:9566 , http://hdl.handle.net/10948/d1016062
- Description: In South Africa, on-going concerns surrounding the development of learners’ literacy, mathematics and science skills are evident and drive various research studies in this field. International studies and assessments, such as the Trends in International Mathematics and Science Study (TIMSS) and the Progress in International Reading Literacy Study (PIRLS) show major differences in the proficiency levels of learners in South Africa in comparison with their international counter parts. To date, however, the more comprehensive international standardised assessment called the Programme for International Student Assessment (PISA), has not been administered in South Africa. The main aim of this research study was to investigate and scientifically explore the real situation in terms of language, mathematics and science literacy knowledge and skills of Grade 9 learners in South Africa and to draw a comparison between Grade 9 learners from secondary schools in the Port Elizabeth district in South Africa and their international counterparts, using the PISA standardised international assessment. In addition, the aim of the study was to determine the actual language, mathematics and science literacy skills and knowledge acquired by participants in this study. Quantitative data collection was done by administering a modified version of the Program for International Student Assessment (PISA) to learners from eight schools in Port Elizabeth, supplemented with questionnaires completed by participating learners and school principals. Findings revealed that the South African learners sampled, ranked in the bottom percentile of participating countries in reading, mathematics and science. The study also exposed the glaring inequalities still prevalent in South African education today, 17 years into democracy. The implications point to a serious investigation into the societal and political factors responsible for the discrepancies in the South African educational system at present.
- Full Text:
- Date Issued: 2012
- Authors: Arnolds, Keith Victor
- Date: 2012
- Subjects: Educational tests and measurements -- South Africa -- Port Elizabeth , Comparative education , Language and languages -- Study and teaching -- South Africa -- Port Elizabeth , Mathematics -- Study and teaching -- South Africa -- Port Elizabeth , Science -- Study and teaching -- South Africa -- Port Elizabeth , Education, Secondary -- South Africa -- Port Elizabeth
- Language: English
- Type: Thesis , Doctoral , DEd
- Identifier: vital:9566 , http://hdl.handle.net/10948/d1016062
- Description: In South Africa, on-going concerns surrounding the development of learners’ literacy, mathematics and science skills are evident and drive various research studies in this field. International studies and assessments, such as the Trends in International Mathematics and Science Study (TIMSS) and the Progress in International Reading Literacy Study (PIRLS) show major differences in the proficiency levels of learners in South Africa in comparison with their international counter parts. To date, however, the more comprehensive international standardised assessment called the Programme for International Student Assessment (PISA), has not been administered in South Africa. The main aim of this research study was to investigate and scientifically explore the real situation in terms of language, mathematics and science literacy knowledge and skills of Grade 9 learners in South Africa and to draw a comparison between Grade 9 learners from secondary schools in the Port Elizabeth district in South Africa and their international counterparts, using the PISA standardised international assessment. In addition, the aim of the study was to determine the actual language, mathematics and science literacy skills and knowledge acquired by participants in this study. Quantitative data collection was done by administering a modified version of the Program for International Student Assessment (PISA) to learners from eight schools in Port Elizabeth, supplemented with questionnaires completed by participating learners and school principals. Findings revealed that the South African learners sampled, ranked in the bottom percentile of participating countries in reading, mathematics and science. The study also exposed the glaring inequalities still prevalent in South African education today, 17 years into democracy. The implications point to a serious investigation into the societal and political factors responsible for the discrepancies in the South African educational system at present.
- Full Text:
- Date Issued: 2012
An analysis of the availability of and access to credit from the formal financial sector and the performance of SMEs
- Authors: Asah, Francis Tangwo
- Date: 2019
- Subjects: Small business -- South Africa -- Finance , Microfinance -- South Africa , South Africa -- Economic conditions -- 1991-
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/115138 , vital:34081
- Description: As a developing nation, South Africa faces a high rate of poverty, high levels of inequality in terms of income and a high rate of unemployment. It is officially estimated that about 27.2% of the economically active population are unemployed. SMEs are expected to be an important vehicle to address the challenges of job creation, sustainable economic growth, equitable distribution of income and the overall stimulation of economic development. SMEs in South Africa constitute 99% of all businesses, contributing to employment, income inequality and poverty alleviation (Statistic South Africa, 2018). However, despite the remarkable contribution of SMEs to the economy of South Africa, the failure rate of SMEs (at 75%) is the highest of all the efficiency-driven economies sampled by the Global Entrepreneurship Monitor (GEM). The World Bank affirm that the availability of and access to credit from the formal financial sector is the primary cause of the high failure rate of SMEs. Contemporary literature advance that the future survival and performance of SMEs in South Africa is pegged onto the amount of financial capital available to address their capital needs. Thus, this study sought to analyse the availability of and access to credit from the formal financial sector and the performance of SMEs from the supply and demand-side. In order to achieve the objectives of the study, a sequential exploratory mixed method research design, located in the pragmatic research paradigm, was used in a two phased approach. The qualitative data collection and analysis in Phase 1 informed the quantitative data collection and analysis Phase 2. In Phase 1, in-depth face-to-face semi-structured interviews were conducted with 8 credit and 8 business managers representing the sampling unit of selected formal financial institutions. The qualitative data collected was analysed using the five-steps process of content analysis as illustrated by Terre Blanche et al. (2006:322-326). The main findings with regard to factors that impact on the willingness of the formal financial sector to provide credit to SMEs were collateral, annual business turnover, audited financial records, relationship with the bank, credit profile, nature of the business, economic climate, ethics, nationality, government policy, management team, valid Identity Document/permit, equity contribution, entrepreneurship education, product quality, and business intelligence. Assessing credit applications from SMEs, risk assessment, inspection of financial records, proper documentation and background checks were the different tasks performed by credit and business managers. In addition, the main challenges faced by the formal financial sector in assessing and approving credit in favour of SMEs included the following: lack of investment capital; lack of collateral; lack of proper financial records; poor managerial knowledge; poor business plan; lack of industrial knowledge; and poor legal and credit laws. Lastly, contrary to the notion that formal financial institutions are not interested in investing in SMEs, on average, 70% of SMEs that applied for credit received such credit. In Phase 2, a self-administered questionnaire was used to collect data from formal sector owner/managers of SMEs in the city of Johannesburg. Of the 702 questionnaires distributed, 300 were returned and useable. Data was analysed using the Statistical Package for the Social Sciences (version 24). A test for normality was performed using Shapiro–Wilks test. Reliability was tested using the Cronbach’s Alpha Coefficient. Exploratory factor analysis tested the validity of factors that prevent formal financial sector from granting credit to SMEs while Binary logistic regression was used to infer on the hypotheses. Spearman’s Rho correlation analysis was used to determine whether there was any significant relationship with factors that influence access to credit and SMEs performance. The main findings revealed that access to bank finance was the only challenge that showed a significant correlation with performance. In addition, the study revealed that the South African Identity Document and collateral were the most important factors considered when applying for credit from formal financial institutions. With regard to the reasons why formal financial institutions may refuse to grant credit to SMEs, it was revealed that there was no significant positive relationship between lack of business networking and access to credit from the formal financial sector to SMEs. Conversely, the study also revealed a significant positive relationship between collateral, business information, managerial competency, business intelligence, business ethics, entrepreneurship education, legal system and macro-economy and access to credit from the formal financial sector to SMEs. Thus, it was established that there is a significant positive relationship between access to credit from the formal financial sector and the performance of SMEs.
- Full Text:
- Date Issued: 2019
- Authors: Asah, Francis Tangwo
- Date: 2019
- Subjects: Small business -- South Africa -- Finance , Microfinance -- South Africa , South Africa -- Economic conditions -- 1991-
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/115138 , vital:34081
- Description: As a developing nation, South Africa faces a high rate of poverty, high levels of inequality in terms of income and a high rate of unemployment. It is officially estimated that about 27.2% of the economically active population are unemployed. SMEs are expected to be an important vehicle to address the challenges of job creation, sustainable economic growth, equitable distribution of income and the overall stimulation of economic development. SMEs in South Africa constitute 99% of all businesses, contributing to employment, income inequality and poverty alleviation (Statistic South Africa, 2018). However, despite the remarkable contribution of SMEs to the economy of South Africa, the failure rate of SMEs (at 75%) is the highest of all the efficiency-driven economies sampled by the Global Entrepreneurship Monitor (GEM). The World Bank affirm that the availability of and access to credit from the formal financial sector is the primary cause of the high failure rate of SMEs. Contemporary literature advance that the future survival and performance of SMEs in South Africa is pegged onto the amount of financial capital available to address their capital needs. Thus, this study sought to analyse the availability of and access to credit from the formal financial sector and the performance of SMEs from the supply and demand-side. In order to achieve the objectives of the study, a sequential exploratory mixed method research design, located in the pragmatic research paradigm, was used in a two phased approach. The qualitative data collection and analysis in Phase 1 informed the quantitative data collection and analysis Phase 2. In Phase 1, in-depth face-to-face semi-structured interviews were conducted with 8 credit and 8 business managers representing the sampling unit of selected formal financial institutions. The qualitative data collected was analysed using the five-steps process of content analysis as illustrated by Terre Blanche et al. (2006:322-326). The main findings with regard to factors that impact on the willingness of the formal financial sector to provide credit to SMEs were collateral, annual business turnover, audited financial records, relationship with the bank, credit profile, nature of the business, economic climate, ethics, nationality, government policy, management team, valid Identity Document/permit, equity contribution, entrepreneurship education, product quality, and business intelligence. Assessing credit applications from SMEs, risk assessment, inspection of financial records, proper documentation and background checks were the different tasks performed by credit and business managers. In addition, the main challenges faced by the formal financial sector in assessing and approving credit in favour of SMEs included the following: lack of investment capital; lack of collateral; lack of proper financial records; poor managerial knowledge; poor business plan; lack of industrial knowledge; and poor legal and credit laws. Lastly, contrary to the notion that formal financial institutions are not interested in investing in SMEs, on average, 70% of SMEs that applied for credit received such credit. In Phase 2, a self-administered questionnaire was used to collect data from formal sector owner/managers of SMEs in the city of Johannesburg. Of the 702 questionnaires distributed, 300 were returned and useable. Data was analysed using the Statistical Package for the Social Sciences (version 24). A test for normality was performed using Shapiro–Wilks test. Reliability was tested using the Cronbach’s Alpha Coefficient. Exploratory factor analysis tested the validity of factors that prevent formal financial sector from granting credit to SMEs while Binary logistic regression was used to infer on the hypotheses. Spearman’s Rho correlation analysis was used to determine whether there was any significant relationship with factors that influence access to credit and SMEs performance. The main findings revealed that access to bank finance was the only challenge that showed a significant correlation with performance. In addition, the study revealed that the South African Identity Document and collateral were the most important factors considered when applying for credit from formal financial institutions. With regard to the reasons why formal financial institutions may refuse to grant credit to SMEs, it was revealed that there was no significant positive relationship between lack of business networking and access to credit from the formal financial sector to SMEs. Conversely, the study also revealed a significant positive relationship between collateral, business information, managerial competency, business intelligence, business ethics, entrepreneurship education, legal system and macro-economy and access to credit from the formal financial sector to SMEs. Thus, it was established that there is a significant positive relationship between access to credit from the formal financial sector and the performance of SMEs.
- Full Text:
- Date Issued: 2019
The autecology of Azolla filiculoides Lamarck with special reference to its occurrence in the Hendrik Verwoerd Dam catchment area
- Authors: Ashton, Peter John
- Date: 1983
- Subjects: Azolla filiculoides -- South Africa -- Gariep Dam Azollaceae Azolla -- South Africa -- Gariep Dam Water ferns -- South Africa -- Gariep Dam Aquatic weeds -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4181 , http://hdl.handle.net/10962/d1003732
- Description: An autecological study of the heterosporous fern Azolla filiculoides Lamarck and its endosymbiotic blue-green alga Anabaena azollae Strasburger, based on a combination of field and laboratory studies, is presented. The taxonomy, morphology and anatomy of the fern-alga association were studied as well as nutritional and physiological aspects of the symbiosis. These studies have defined the habitat and nutritional requirements of the fern and have provided new insights into its reproductive biology, nitrogen metabolism and the nature of the association between the fern and alga. In the catchment area of the Hendrik Verwoerd Dam the availability of suitably sheltered habitat limits the distribution of A. filiculoides while the availability of nutrients, in particular calcium, phosphorus and iron, limits the growth of the fern. The multilayered mats formed by A. filiculoides are essential for spore production, cause dramatic changes in the hydrochemistry of the underlying waters and confer a great competitive advantage on the plant. Methods for the isolation of the fern and algal components of the symbiosis have been developed but recombination of the individual organisms to reform the symbiosis was unsuccessful. The development of the fern is closely linked to that of the alga and the association is maintained throughout the life cycle of the fern. Because of its specific habitat and nutritional requirements, A. filiculoides is unlikely to colonize the open waters of the Hendrik Verwoerd Dam.
- Full Text:
- Date Issued: 1983
- Authors: Ashton, Peter John
- Date: 1983
- Subjects: Azolla filiculoides -- South Africa -- Gariep Dam Azollaceae Azolla -- South Africa -- Gariep Dam Water ferns -- South Africa -- Gariep Dam Aquatic weeds -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4181 , http://hdl.handle.net/10962/d1003732
- Description: An autecological study of the heterosporous fern Azolla filiculoides Lamarck and its endosymbiotic blue-green alga Anabaena azollae Strasburger, based on a combination of field and laboratory studies, is presented. The taxonomy, morphology and anatomy of the fern-alga association were studied as well as nutritional and physiological aspects of the symbiosis. These studies have defined the habitat and nutritional requirements of the fern and have provided new insights into its reproductive biology, nitrogen metabolism and the nature of the association between the fern and alga. In the catchment area of the Hendrik Verwoerd Dam the availability of suitably sheltered habitat limits the distribution of A. filiculoides while the availability of nutrients, in particular calcium, phosphorus and iron, limits the growth of the fern. The multilayered mats formed by A. filiculoides are essential for spore production, cause dramatic changes in the hydrochemistry of the underlying waters and confer a great competitive advantage on the plant. Methods for the isolation of the fern and algal components of the symbiosis have been developed but recombination of the individual organisms to reform the symbiosis was unsuccessful. The development of the fern is closely linked to that of the alga and the association is maintained throughout the life cycle of the fern. Because of its specific habitat and nutritional requirements, A. filiculoides is unlikely to colonize the open waters of the Hendrik Verwoerd Dam.
- Full Text:
- Date Issued: 1983
Effective and efficient performance management in local government, with reference to the Cacadu District Municipality
- Authors: Asmah-Andoh, Kwame
- Date: 2012
- Subjects: Performance -- Management , Performance standards -- South Africa -- Eastern Cape , Municipal government -- South Africa -- Eastern Cape , Employees -- Rating of -- South Africa
- Language: English
- Type: Thesis , Doctoral , DPhil
- Identifier: vital:8161 , http://hdl.handle.net/10948/1633 , Performance -- Management , Performance standards -- South Africa -- Eastern Cape , Municipal government -- South Africa -- Eastern Cape , Employees -- Rating of -- South Africa
- Description: This study examined the existing levels of effectiveness and efficiency in local government with the application of performance management systems in the provision of municipal services. The provision of district-wide water services in Cacadu District Municipality in the Province of the Eastern Cape, South Africa is used for particular reference. Local government reforms after 1994 led to the creation of the district municipality (which groups together a number of local municipalities) to drive district-wide services provision, the introduction of systematic services provision standards and performance management as part of management reforms in municipalities. The problem for the research deals with how the Cacadu District Council and the councils of the local municipalities within the district are collaborating in using performance management systems, what effects this could have on programmes and services provision and how communication of performance information would improve service provision. Conceptual and practical difficulties encountered in effective and efficient utilisation and some obstacles that contribute to impeding progress in the use of performance management systems in municipalities were analysed. The qualitative research included a review of documents from the public administration and management literature; discourse analysis of interviews with municipal councilors and appointed officials, community members and provincial managers. The document review included a review of municipal documents that incorporated performance management or described development and use of performance management systems. It also included the legal frameworks and statutory requirements for municipal government and administration. All the responding municipal councils within the Cacadu District Municipality reported using performance management over the past five years yet little empirical evidence explains usage for district-wide programmes and services provision. Research shows that a comprehensive performance management approach to programmes and services has a more effective and efficient impact on service improvement than utilisation of personnnel appraisal (Ammons and Rivenbark, 2005). Despite the expected benefits, personnel performance appraisal is often flawed and the need exists in the district municipal model to develop and utilise performance management systems that validly assess the work performance of personnel (Hindo, 2010). Performance management system utilisation in decision making management is more related to the long-term benefits of effectiveness and efficiency than personnel appraisal for performance rewards and reporting. To overcome and address a situation of managing performance without a performance management system the study proposes a programme performance measurement and management system which incorporates information on management inputs, programme-specific data and citizens' feedback for outcomes and impact of the service. The suggested design for district-wide and specific municipal services provision elicit and provide relevant and appropriate performance information for management, decision-making and accountability to community. The effectiveness of the proposed system is to provide information for decision-making, long-term planning, strategic management and accountability reporting. The proposal is built on the exisiting method and thus efficient in the utilisation of resources. This has implications both for the theory of Public Administration and Management and the practical application of performamce management in public institutions. The study explicity provides a Public Administration perspective on management in a multi-municipal district context with different authorities. The study contributes to the theory of administrative policy and management context of the municipality with special attention to functions for which different authorities are responsible and the role of a performance system for better insught into managing overlapping authority, gaps and duplications. A central purpose of public management research is to theorise and influence practice. The practical utilisation of the proposed method is intended to assist managers and politicians with better understanding of a sustainable performance management system.
- Full Text:
- Date Issued: 2012
- Authors: Asmah-Andoh, Kwame
- Date: 2012
- Subjects: Performance -- Management , Performance standards -- South Africa -- Eastern Cape , Municipal government -- South Africa -- Eastern Cape , Employees -- Rating of -- South Africa
- Language: English
- Type: Thesis , Doctoral , DPhil
- Identifier: vital:8161 , http://hdl.handle.net/10948/1633 , Performance -- Management , Performance standards -- South Africa -- Eastern Cape , Municipal government -- South Africa -- Eastern Cape , Employees -- Rating of -- South Africa
- Description: This study examined the existing levels of effectiveness and efficiency in local government with the application of performance management systems in the provision of municipal services. The provision of district-wide water services in Cacadu District Municipality in the Province of the Eastern Cape, South Africa is used for particular reference. Local government reforms after 1994 led to the creation of the district municipality (which groups together a number of local municipalities) to drive district-wide services provision, the introduction of systematic services provision standards and performance management as part of management reforms in municipalities. The problem for the research deals with how the Cacadu District Council and the councils of the local municipalities within the district are collaborating in using performance management systems, what effects this could have on programmes and services provision and how communication of performance information would improve service provision. Conceptual and practical difficulties encountered in effective and efficient utilisation and some obstacles that contribute to impeding progress in the use of performance management systems in municipalities were analysed. The qualitative research included a review of documents from the public administration and management literature; discourse analysis of interviews with municipal councilors and appointed officials, community members and provincial managers. The document review included a review of municipal documents that incorporated performance management or described development and use of performance management systems. It also included the legal frameworks and statutory requirements for municipal government and administration. All the responding municipal councils within the Cacadu District Municipality reported using performance management over the past five years yet little empirical evidence explains usage for district-wide programmes and services provision. Research shows that a comprehensive performance management approach to programmes and services has a more effective and efficient impact on service improvement than utilisation of personnnel appraisal (Ammons and Rivenbark, 2005). Despite the expected benefits, personnel performance appraisal is often flawed and the need exists in the district municipal model to develop and utilise performance management systems that validly assess the work performance of personnel (Hindo, 2010). Performance management system utilisation in decision making management is more related to the long-term benefits of effectiveness and efficiency than personnel appraisal for performance rewards and reporting. To overcome and address a situation of managing performance without a performance management system the study proposes a programme performance measurement and management system which incorporates information on management inputs, programme-specific data and citizens' feedback for outcomes and impact of the service. The suggested design for district-wide and specific municipal services provision elicit and provide relevant and appropriate performance information for management, decision-making and accountability to community. The effectiveness of the proposed system is to provide information for decision-making, long-term planning, strategic management and accountability reporting. The proposal is built on the exisiting method and thus efficient in the utilisation of resources. This has implications both for the theory of Public Administration and Management and the practical application of performamce management in public institutions. The study explicity provides a Public Administration perspective on management in a multi-municipal district context with different authorities. The study contributes to the theory of administrative policy and management context of the municipality with special attention to functions for which different authorities are responsible and the role of a performance system for better insught into managing overlapping authority, gaps and duplications. A central purpose of public management research is to theorise and influence practice. The practical utilisation of the proposed method is intended to assist managers and politicians with better understanding of a sustainable performance management system.
- Full Text:
- Date Issued: 2012
Pharmacological studies of Foeniculum Vulgare (Mill.) and Lippia Javanica (Burm.F.) spreng. used as spices in Nkonkobe Municipality of the Eastern Cape Province, South Africa
- Asowata-Ayodele, Abiola Mojisola
- Authors: Asowata-Ayodele, Abiola Mojisola
- Date: 2016
- Subjects: Medicinal plants -- South Africa -- Eastern Cape Fennel -- Utilization -- South Africa -- Eastern Cape Ethnopharmacology -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10353/2777 , vital:28085
- Description: Spices are of great importance in the indigenous culinary and traditional medicine systems of the people of Nkonkobe Municipality of the Eastern Cape, South Africa. The present investigation evaluated the ethnopharmacological potentials of two indigenous South African spices- Foeniculum vulgare and Lippia javanica. The pharmacological investigations on these two plant species include ultra-morphology, nutrient and mineral analysis, evaluation of the essential oil, phytochemical and antioxidant assays, antimicrobial, anti-inflammatory as well as anti-urolithiatic assay of the acetone and aqueous extracts of the two plants. The species were selected for study as the most cited plants after an ethnobotanical survey conducted on the indigenous knowledge of plants used as spices and medicine in Nkonkobe Municipality, Eastern Cape of South Africa. Among the plants cited Foeniculum vulgare(Apiaceae) and Lippia javanica (Verbenaceae) stood out as the most commonly used spices. Others were members of the families; Solanaceae, Apiaceae, Amaryllidaceae, Amaranthaceae and Lamiaceae. Ultra-morphological studies conducted on the leaves of the two selected plants using scanning electron microscope revealed the presence of non-glandular and glandular trichomes, stomata and crystals. The leaf surfaces of these herbs may serve as secretory sites where aromatic secondary metabolites are produced. Analyses of the proximate, mineral, vitamin and anti-nutrients contents of these two spices showed that both species are good sources of these phytochemicals and may be used to enrich the human diet. Lippia javanica possesses lower lipid (0.50 percent), fibre (5 percent) and carbohydrate (64.96 percent) contents than Foeniculum vulgare. On the other hand, protein (20.54 percent), ash (11.60 percent) and moisture content (11.69 percent) were higher in Foeniculum vulgare than in Lippia javanica. Foeniculum vulgare showed higher N (3286 mg/100g), Mg (386.7 mg/100g), K (3187 mg/100g) and Na (1383 mg/100g) content while Lippia javanica was higher in Ca (1833 mg/100g), Zn (4.7 mg/100g), Cu (0.9 mg/100g) and Fe (78.4 mg/100g). Vitamins Aand E were also higher in Lippia javanica (1.31 mg/100g; 2.52 mg/100g) while Foeniculum vulgare (0.45 mg/100g) had higher vitamin C content. No significant differences were observed in the phytate, oxalate and tannin contents of the two spices, but saponin and cyanide were significantly lower in Lippia javanica (268.5 mg/100g; 8.45 mg/100g) than in Foeniculum vulgare (1855 mg/100g; 10.5 mg/100g) Evaluation of the essential oil component, cytotoxicity and antimicrobial activities of both fresh and dried leaves of Lippia javanica and Foeniculum vulgare revealed that the dried samples yielded more oil and also contain more chemical than the fresh samples of both plants. The overall antimicrobial activity evaluated using susceptibility and microdilution assays revealed that the oils of F. vulgare and L. javanica exhibited high antifungal and antibacterial activity, compared to the reference drugs. In addition, essential oil from fresh leaves of both spices was less toxic compared to the oil from the dried leaves. Polyphenolic evaluation of the aqueous and acetone extracts of the plants revealed that the acetone extract had higher phenol, flavanol, flavonoid and proanthocyanidin contents than the aqueous extracts. The total phenolic content of acetone and aqueous extracts were 4.49 ± 0.411 mg/g and 3.73 ± 0.498 mg/g tannic acid equivalent (TAE) respectively for Lippia javanica. The same trend was also observed in Foeniculum vulgare with total phenolic content of acetone and aqueous extracts were 4.22 ± 0.325 mg/g and 4.17 ± 0.651 mg/g tannic acid equivalent (TAE) respectively. Further assessment of the antioxidant activity of the solvent extracts revealed that both plants exhibited promising free radical scavenging potentials against 1,1 diphenyl-2-picrylhydrazyl (DPPH), 2, 2’-azino-bis(3- ethylbenzthiazoline-6-sulfonic acid (ABTS), reducing power, lipid peroxidation, nitric oxide, phosphomolybdate and hydrogen peroxide. Antimicrobial activities of the acetone and aqueous extracts of the two plants revealed moderate antibacterial and antifungal activities. They inhibited the growth of Microsporium canis and Trichophyton rubrum that were not susceptible to the standard antifungal drug used as control.
- Full Text:
- Date Issued: 2016
- Authors: Asowata-Ayodele, Abiola Mojisola
- Date: 2016
- Subjects: Medicinal plants -- South Africa -- Eastern Cape Fennel -- Utilization -- South Africa -- Eastern Cape Ethnopharmacology -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10353/2777 , vital:28085
- Description: Spices are of great importance in the indigenous culinary and traditional medicine systems of the people of Nkonkobe Municipality of the Eastern Cape, South Africa. The present investigation evaluated the ethnopharmacological potentials of two indigenous South African spices- Foeniculum vulgare and Lippia javanica. The pharmacological investigations on these two plant species include ultra-morphology, nutrient and mineral analysis, evaluation of the essential oil, phytochemical and antioxidant assays, antimicrobial, anti-inflammatory as well as anti-urolithiatic assay of the acetone and aqueous extracts of the two plants. The species were selected for study as the most cited plants after an ethnobotanical survey conducted on the indigenous knowledge of plants used as spices and medicine in Nkonkobe Municipality, Eastern Cape of South Africa. Among the plants cited Foeniculum vulgare(Apiaceae) and Lippia javanica (Verbenaceae) stood out as the most commonly used spices. Others were members of the families; Solanaceae, Apiaceae, Amaryllidaceae, Amaranthaceae and Lamiaceae. Ultra-morphological studies conducted on the leaves of the two selected plants using scanning electron microscope revealed the presence of non-glandular and glandular trichomes, stomata and crystals. The leaf surfaces of these herbs may serve as secretory sites where aromatic secondary metabolites are produced. Analyses of the proximate, mineral, vitamin and anti-nutrients contents of these two spices showed that both species are good sources of these phytochemicals and may be used to enrich the human diet. Lippia javanica possesses lower lipid (0.50 percent), fibre (5 percent) and carbohydrate (64.96 percent) contents than Foeniculum vulgare. On the other hand, protein (20.54 percent), ash (11.60 percent) and moisture content (11.69 percent) were higher in Foeniculum vulgare than in Lippia javanica. Foeniculum vulgare showed higher N (3286 mg/100g), Mg (386.7 mg/100g), K (3187 mg/100g) and Na (1383 mg/100g) content while Lippia javanica was higher in Ca (1833 mg/100g), Zn (4.7 mg/100g), Cu (0.9 mg/100g) and Fe (78.4 mg/100g). Vitamins Aand E were also higher in Lippia javanica (1.31 mg/100g; 2.52 mg/100g) while Foeniculum vulgare (0.45 mg/100g) had higher vitamin C content. No significant differences were observed in the phytate, oxalate and tannin contents of the two spices, but saponin and cyanide were significantly lower in Lippia javanica (268.5 mg/100g; 8.45 mg/100g) than in Foeniculum vulgare (1855 mg/100g; 10.5 mg/100g) Evaluation of the essential oil component, cytotoxicity and antimicrobial activities of both fresh and dried leaves of Lippia javanica and Foeniculum vulgare revealed that the dried samples yielded more oil and also contain more chemical than the fresh samples of both plants. The overall antimicrobial activity evaluated using susceptibility and microdilution assays revealed that the oils of F. vulgare and L. javanica exhibited high antifungal and antibacterial activity, compared to the reference drugs. In addition, essential oil from fresh leaves of both spices was less toxic compared to the oil from the dried leaves. Polyphenolic evaluation of the aqueous and acetone extracts of the plants revealed that the acetone extract had higher phenol, flavanol, flavonoid and proanthocyanidin contents than the aqueous extracts. The total phenolic content of acetone and aqueous extracts were 4.49 ± 0.411 mg/g and 3.73 ± 0.498 mg/g tannic acid equivalent (TAE) respectively for Lippia javanica. The same trend was also observed in Foeniculum vulgare with total phenolic content of acetone and aqueous extracts were 4.22 ± 0.325 mg/g and 4.17 ± 0.651 mg/g tannic acid equivalent (TAE) respectively. Further assessment of the antioxidant activity of the solvent extracts revealed that both plants exhibited promising free radical scavenging potentials against 1,1 diphenyl-2-picrylhydrazyl (DPPH), 2, 2’-azino-bis(3- ethylbenzthiazoline-6-sulfonic acid (ABTS), reducing power, lipid peroxidation, nitric oxide, phosphomolybdate and hydrogen peroxide. Antimicrobial activities of the acetone and aqueous extracts of the two plants revealed moderate antibacterial and antifungal activities. They inhibited the growth of Microsporium canis and Trichophyton rubrum that were not susceptible to the standard antifungal drug used as control.
- Full Text:
- Date Issued: 2016
An investigation of statistical methodologies for evaluating natural herbicides for the control of yellow nutsedge (Cyperus esculentus)
- Authors: Asquith, Ilse Bernadette
- Date: 2007
- Subjects: Chemometrics , Weeds
- Language: English
- Type: Thesis , Doctoral , DTech (Chemistry)
- Identifier: vital:10376 , Chemometrics , Weeds
- Description: The present study was undertaken with the view to evaluate methodologies based on traditional Scheffé experimental designs that study mixtures as a tool for discovery research particularly when seeking new and or improved uses of existing mixtures. For the purpose of this study, the topic of controlling the problematic weed known as Yellow Nutsedge (Cyperus esculentus L. var. esculentus) or “Geel Uintjie”, was selected on a rather ad hoc basis. Yellow Nutsedge is a troublesome perennial weed found in most agricultural countries in the world. Herbicidal control is often difficult because of the weeds’ ability to propagate via tubers, which can remain dormant for a number of years and are also resistant to most synthetic herbicide controls. As a first step the study involved the selection of a group of chemical compounds that would be used in suppressing the germination of Yellow Nutsedge tubers. Treatment with various combinations of these chemical compounds as determined by statistical experimental designs was carried out. A review of the literature, particularly literature concerned with the study of the phenomenon of allelopathy, suggested that various phenolic-D-glucopyranosides could show promise in the suppressing the germination of Yellow Nutsedge tubers. This led to the selection of this group of compounds as the target group of “active” substances for the study. Since the group of phenolic-D-glucopyranosides is quite large, and in order to keep the study to a reasonable size, only four phenolic-D-glucopyranosides were selected namely: 4-nitrophenyl-D-glucopyranoside, 4-chlorophenyl--Dglucopyranoside, arbutin and salicin. This selection was based firstly based on a particular phenolic-D-glucopyranoside being a suspected allelochemical, and secondly the ease of technical synthesis using a catalytic process. In addition to the four selected phenolic-D-glucopyranosides, their aglycones (4,nitrophenol, 4,chlorophenol, hydroquinone and salicyl alcohol) were also included as potential “active” substances in order to discern any potential activity between the phenolic-D-glucopyranosides and the aglycones. iii The selected “active substances” were combined in various combinations according to various mixture designs in such a manner that the sum of the proportions of the various actives in any one mixture was always equal to 1. The mixtures of actives were then used in various germination experiments and three experimental responses were measured namely the germination, average dry mass and length of longest shoot. From the results of these germination studies the canonical form of the polynomial equation describing the variation in each of the three germination responses was calculated and evaluated statistically. These equations were then used to estimate the presence of, and the magnitude of synergism between the various active substances. The results from these screening experiments and their detailed statistical analysis indicated that the response surface model for the germination response contains three synergistic blends (4-nitrophenyl--D-glucopyranoside + arbutin; 4-nitrophenyl--Dglucopyranoside + hydroquinone; and 4-chlorophenyl--D-glucopyranoside + salicin) and one antagonistic blend (4-nitrophenyl--D-glucopyranoside + 4- chlorophenol--D-glucopyranoside). The response surface model for the average dry mass response contains two synergistic blends (4-nitrophenyl--Dglucopyranoside + hydroquinone; and 4-chlorophenol--D-glucopyranoside + salicin) and the same antagonistic blend as for germination response. For both germination and average dry mass responses, the most synergistic blend was found to be the combination of 4-chlorophenyl--D-glucopyranoside and salicin. Two additional tests were conducted and both confirmed the results obtained from the screening designs. These tests involved the identification of the two components responsible for the synergistic activity that resulted in the suppression of the germination of the tubers and growth of the seedlings. The experimental response measuring the longest shoot proved to be erroneous and was excluded from the statistical analysis. In summary, this study has clearly shown that statistically designed experiments based on mixture designs can be used as a powerful tool in identifying and quantifying synergistic (or antagonistic) effects of chemicals on the germination ability of plant seeds.
- Full Text:
- Date Issued: 2007
- Authors: Asquith, Ilse Bernadette
- Date: 2007
- Subjects: Chemometrics , Weeds
- Language: English
- Type: Thesis , Doctoral , DTech (Chemistry)
- Identifier: vital:10376 , Chemometrics , Weeds
- Description: The present study was undertaken with the view to evaluate methodologies based on traditional Scheffé experimental designs that study mixtures as a tool for discovery research particularly when seeking new and or improved uses of existing mixtures. For the purpose of this study, the topic of controlling the problematic weed known as Yellow Nutsedge (Cyperus esculentus L. var. esculentus) or “Geel Uintjie”, was selected on a rather ad hoc basis. Yellow Nutsedge is a troublesome perennial weed found in most agricultural countries in the world. Herbicidal control is often difficult because of the weeds’ ability to propagate via tubers, which can remain dormant for a number of years and are also resistant to most synthetic herbicide controls. As a first step the study involved the selection of a group of chemical compounds that would be used in suppressing the germination of Yellow Nutsedge tubers. Treatment with various combinations of these chemical compounds as determined by statistical experimental designs was carried out. A review of the literature, particularly literature concerned with the study of the phenomenon of allelopathy, suggested that various phenolic-D-glucopyranosides could show promise in the suppressing the germination of Yellow Nutsedge tubers. This led to the selection of this group of compounds as the target group of “active” substances for the study. Since the group of phenolic-D-glucopyranosides is quite large, and in order to keep the study to a reasonable size, only four phenolic-D-glucopyranosides were selected namely: 4-nitrophenyl-D-glucopyranoside, 4-chlorophenyl--Dglucopyranoside, arbutin and salicin. This selection was based firstly based on a particular phenolic-D-glucopyranoside being a suspected allelochemical, and secondly the ease of technical synthesis using a catalytic process. In addition to the four selected phenolic-D-glucopyranosides, their aglycones (4,nitrophenol, 4,chlorophenol, hydroquinone and salicyl alcohol) were also included as potential “active” substances in order to discern any potential activity between the phenolic-D-glucopyranosides and the aglycones. iii The selected “active substances” were combined in various combinations according to various mixture designs in such a manner that the sum of the proportions of the various actives in any one mixture was always equal to 1. The mixtures of actives were then used in various germination experiments and three experimental responses were measured namely the germination, average dry mass and length of longest shoot. From the results of these germination studies the canonical form of the polynomial equation describing the variation in each of the three germination responses was calculated and evaluated statistically. These equations were then used to estimate the presence of, and the magnitude of synergism between the various active substances. The results from these screening experiments and their detailed statistical analysis indicated that the response surface model for the germination response contains three synergistic blends (4-nitrophenyl--D-glucopyranoside + arbutin; 4-nitrophenyl--Dglucopyranoside + hydroquinone; and 4-chlorophenyl--D-glucopyranoside + salicin) and one antagonistic blend (4-nitrophenyl--D-glucopyranoside + 4- chlorophenol--D-glucopyranoside). The response surface model for the average dry mass response contains two synergistic blends (4-nitrophenyl--Dglucopyranoside + hydroquinone; and 4-chlorophenol--D-glucopyranoside + salicin) and the same antagonistic blend as for germination response. For both germination and average dry mass responses, the most synergistic blend was found to be the combination of 4-chlorophenyl--D-glucopyranoside and salicin. Two additional tests were conducted and both confirmed the results obtained from the screening designs. These tests involved the identification of the two components responsible for the synergistic activity that resulted in the suppression of the germination of the tubers and growth of the seedlings. The experimental response measuring the longest shoot proved to be erroneous and was excluded from the statistical analysis. In summary, this study has clearly shown that statistically designed experiments based on mixture designs can be used as a powerful tool in identifying and quantifying synergistic (or antagonistic) effects of chemicals on the germination ability of plant seeds.
- Full Text:
- Date Issued: 2007
Student's van Hiele levels of geometric thought and conception in plane geometry: a collective case study of Nigeria and South Africa
- Authors: Atebe, Humphrey Uyouyo
- Date: 2009
- Subjects: Geometry -- Study and teaching (Secondary) -- Nigeria -- Case studies Geometry -- Study and teaching (Secondary) -- South Africa -- Case studies Mathematics -- Study and teaching (Secondary) -- Nigeria -- Case studies Mathematics -- Study and teaching (Secondary) -- South Africa -- Case studies
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1777 , http://hdl.handle.net/10962/d1003662
- Description: This study is inspired by and utilises the van Hiele theory of geometric thought levels, currently acclaimed as one of the best frameworks for studying teaching and learning processes in geometry. The study aims both to explore and explicate the van Hiele levels of geometric thinking of a selected group of grade 10, 11 and 12 learners in Nigerian and South African schools. The study further aims to provide a rich and indepth description of the geometry instructional practices that possibly contributed to the levels of geometric conceptualisation exhibited by this cohort of high school learners. This collective case study, presented in two volumes, is oriented within an interpretive research paradigm and characterised by both qualitative and quantitative methods. The sample for the study comprised a total of 144 mathematics learners and 6 mathematics teachers from Nigeria and South Africa. They were selected using both purposive and stratified sampling techniques. In using the van Hiele model to interrogate both learners’ levels of geometric conceptualisation and teaching methods in geometry classrooms, the study employs a qualitative and qunatitative approach to the data-collection process, involving the use of questionnaires (in the form of various pen-and-paper tests, hands-on activity-based tests), interviews and classroom videos. Although the data analysis was done largely through descriptive statistics, the whole process inevitably incorporated elements of inferential statistics (e.g. ANOVA and Tukey HSD post-hoc test) in the quest for indepth analysis and deeper interpretation of the data. Learners were assigned to various van Hiele levels, mainly according to Usiskin’s (1982) forced van Hiele level determination scheme. The whole process of analysing the classroom videos involved a consultative panel of 4 observers and 3 critical readers, using the checklist of van Hiele phase descriptors to guide the analysis process. Concerning learners’ levels of geometric conceptualisation, the results from this study reveal that the most of the learners were not yet ready for the formal deductive study of school geometry, as only 2% and 3% of them were respectively at van Hiele levels 3 and 4, while 47%, 22% and 24% were at levels 0, 1 and 2, respectively. More learners from the Nigerian subsample (53%) were at van Hiele level 0 than learners from the South African subsample (41%) at this level. No learner from the Nigerian subsample was at van Hiele level 4, while 6% of the South African learners were at level 4. In general, learners from the Nigerian subsample had a poorer knowledge of school geometry than their peers from the South African subsample, as learners from the latter subsample obtained significantly higher mean scores in the van Hiele Geometry Test (VHGT) and each of the other tests used in this study. Results relating to gender differences in performance generally favour the male learners in this study. For each of the participating schools, learners’ van Hiele levels (as determined by their scores on the VHGT) strongly correlate with their performance in geometry content tests and mathematics generally. For each of the Nigerian and South African subsamples, for n ≤ 2, learners at van Hiele level n obtained higher means on nearly all the tests administered in this study than their peers at level n–1. This finding provides support for the hierarchical property of the van Hiele levels.
- Full Text:
- Date Issued: 2009
- Authors: Atebe, Humphrey Uyouyo
- Date: 2009
- Subjects: Geometry -- Study and teaching (Secondary) -- Nigeria -- Case studies Geometry -- Study and teaching (Secondary) -- South Africa -- Case studies Mathematics -- Study and teaching (Secondary) -- Nigeria -- Case studies Mathematics -- Study and teaching (Secondary) -- South Africa -- Case studies
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1777 , http://hdl.handle.net/10962/d1003662
- Description: This study is inspired by and utilises the van Hiele theory of geometric thought levels, currently acclaimed as one of the best frameworks for studying teaching and learning processes in geometry. The study aims both to explore and explicate the van Hiele levels of geometric thinking of a selected group of grade 10, 11 and 12 learners in Nigerian and South African schools. The study further aims to provide a rich and indepth description of the geometry instructional practices that possibly contributed to the levels of geometric conceptualisation exhibited by this cohort of high school learners. This collective case study, presented in two volumes, is oriented within an interpretive research paradigm and characterised by both qualitative and quantitative methods. The sample for the study comprised a total of 144 mathematics learners and 6 mathematics teachers from Nigeria and South Africa. They were selected using both purposive and stratified sampling techniques. In using the van Hiele model to interrogate both learners’ levels of geometric conceptualisation and teaching methods in geometry classrooms, the study employs a qualitative and qunatitative approach to the data-collection process, involving the use of questionnaires (in the form of various pen-and-paper tests, hands-on activity-based tests), interviews and classroom videos. Although the data analysis was done largely through descriptive statistics, the whole process inevitably incorporated elements of inferential statistics (e.g. ANOVA and Tukey HSD post-hoc test) in the quest for indepth analysis and deeper interpretation of the data. Learners were assigned to various van Hiele levels, mainly according to Usiskin’s (1982) forced van Hiele level determination scheme. The whole process of analysing the classroom videos involved a consultative panel of 4 observers and 3 critical readers, using the checklist of van Hiele phase descriptors to guide the analysis process. Concerning learners’ levels of geometric conceptualisation, the results from this study reveal that the most of the learners were not yet ready for the formal deductive study of school geometry, as only 2% and 3% of them were respectively at van Hiele levels 3 and 4, while 47%, 22% and 24% were at levels 0, 1 and 2, respectively. More learners from the Nigerian subsample (53%) were at van Hiele level 0 than learners from the South African subsample (41%) at this level. No learner from the Nigerian subsample was at van Hiele level 4, while 6% of the South African learners were at level 4. In general, learners from the Nigerian subsample had a poorer knowledge of school geometry than their peers from the South African subsample, as learners from the latter subsample obtained significantly higher mean scores in the van Hiele Geometry Test (VHGT) and each of the other tests used in this study. Results relating to gender differences in performance generally favour the male learners in this study. For each of the participating schools, learners’ van Hiele levels (as determined by their scores on the VHGT) strongly correlate with their performance in geometry content tests and mathematics generally. For each of the Nigerian and South African subsamples, for n ≤ 2, learners at van Hiele level n obtained higher means on nearly all the tests administered in this study than their peers at level n–1. This finding provides support for the hierarchical property of the van Hiele levels.
- Full Text:
- Date Issued: 2009
Data compression, field of interest shaping and fast algorithms for direction-dependent deconvolution in radio interferometry
- Authors: Atemkeng, Marcellin T
- Date: 2017
- Subjects: Radio astronomy , Solar radio emission , Radio interferometers , Signal processing -- Digital techniques , Algorithms , Data compression (Computer science)
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/6324 , vital:21089
- Description: In radio interferometry, observed visibilities are intrinsically sampled at some interval in time and frequency. Modern interferometers are capable of producing data at very high time and frequency resolution; practical limits on storage and computation costs require that some form of data compression be imposed. The traditional form of compression is simple averaging of the visibilities over coarser time and frequency bins. This has an undesired side effect: the resulting averaged visibilities “decorrelate”, and do so differently depending on the baseline length and averaging interval. This translates into a non-trivial signature in the image domain known as “smearing”, which manifests itself as an attenuation in amplitude towards off-centre sources. With the increasing fields of view and/or longer baselines employed in modern and future instruments, the trade-off between data rate and smearing becomes increasingly unfavourable. Averaging also results in baseline length and a position-dependent point spread function (PSF). In this work, we investigate alternative approaches to low-loss data compression. We show that averaging of the visibility data can be understood as a form of convolution by a boxcar-like window function, and that by employing alternative baseline-dependent window functions a more optimal interferometer smearing response may be induced. Specifically, we can improve amplitude response over a chosen field of interest and attenuate sources outside the field of interest. The main cost of this technique is a reduction in nominal sensitivity; we investigate the smearing vs. sensitivity trade-off and show that in certain regimes a favourable compromise can be achieved. We show the application of this technique to simulated data from the Jansky Very Large Array and the European Very Long Baseline Interferometry Network. Furthermore, we show that the position-dependent PSF shape induced by averaging can be approximated using linear algebraic properties to effectively reduce the computational complexity for evaluating the PSF at each sky position. We conclude by implementing a position-dependent PSF deconvolution in an imaging and deconvolution framework. Using the Low-Frequency Array radio interferometer, we show that deconvolution with position-dependent PSFs results in higher image fidelity compared to a simple CLEAN algorithm and its derivatives.
- Full Text:
- Date Issued: 2017
- Authors: Atemkeng, Marcellin T
- Date: 2017
- Subjects: Radio astronomy , Solar radio emission , Radio interferometers , Signal processing -- Digital techniques , Algorithms , Data compression (Computer science)
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/6324 , vital:21089
- Description: In radio interferometry, observed visibilities are intrinsically sampled at some interval in time and frequency. Modern interferometers are capable of producing data at very high time and frequency resolution; practical limits on storage and computation costs require that some form of data compression be imposed. The traditional form of compression is simple averaging of the visibilities over coarser time and frequency bins. This has an undesired side effect: the resulting averaged visibilities “decorrelate”, and do so differently depending on the baseline length and averaging interval. This translates into a non-trivial signature in the image domain known as “smearing”, which manifests itself as an attenuation in amplitude towards off-centre sources. With the increasing fields of view and/or longer baselines employed in modern and future instruments, the trade-off between data rate and smearing becomes increasingly unfavourable. Averaging also results in baseline length and a position-dependent point spread function (PSF). In this work, we investigate alternative approaches to low-loss data compression. We show that averaging of the visibility data can be understood as a form of convolution by a boxcar-like window function, and that by employing alternative baseline-dependent window functions a more optimal interferometer smearing response may be induced. Specifically, we can improve amplitude response over a chosen field of interest and attenuate sources outside the field of interest. The main cost of this technique is a reduction in nominal sensitivity; we investigate the smearing vs. sensitivity trade-off and show that in certain regimes a favourable compromise can be achieved. We show the application of this technique to simulated data from the Jansky Very Large Array and the European Very Long Baseline Interferometry Network. Furthermore, we show that the position-dependent PSF shape induced by averaging can be approximated using linear algebraic properties to effectively reduce the computational complexity for evaluating the PSF at each sky position. We conclude by implementing a position-dependent PSF deconvolution in an imaging and deconvolution framework. Using the Low-Frequency Array radio interferometer, we show that deconvolution with position-dependent PSFs results in higher image fidelity compared to a simple CLEAN algorithm and its derivatives.
- Full Text:
- Date Issued: 2017
Investigations into the ecology of a population of Citrus Red Scale (Aonidiella aurantii Mask.) in the Swaziland lowlands
- Authors: Atkinson, P R
- Date: 1982
- Subjects: Citrus -- Diseases and pests -- Africa, Southern
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5619 , http://hdl.handle.net/10962/d1003733
- Description: In the Swaziland lowlands, biological control of the citrus pest red scale, Aonidiella aurantii (Mask), has been consistently unsuccessful although it is successful in middle altitude regions. However, recent cases of resistance to organophosphate insecticides elsewhere in southern Africa, make it important to reconsider biological control of red scale in the lowlands. Should similar resistance be evolved in this region, the pest could be controlled only by natural means together with oils. This account attempts to answer questions about the natural control of a red scale population in the lowlands, by examining data collected between 1972 and 1975. The population was continuously breeding with overlapped generations. It consisted of three sections, on leaves, twigs and fruit, having different rates of reproduction, development and mortality. These sections are considered separately but that on leaves, being relatively unimportant, is largely ignored. The generation mortality is estimated in the sections on twigs and fruit and related to climatic and biotic indices. The causes of seasonal and between-years variation in the sections on twigs and fruit are elucidated. The effectiveness of each kind of natural enemy is examined and the factors affecting natural enemy numbers are investigated. The question of population regulation is discussed. Differences in mean infestation levels in middle altitude and lowland regions are explained in terms of different rates of reproduction and mortality.
- Full Text:
- Date Issued: 1982
- Authors: Atkinson, P R
- Date: 1982
- Subjects: Citrus -- Diseases and pests -- Africa, Southern
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5619 , http://hdl.handle.net/10962/d1003733
- Description: In the Swaziland lowlands, biological control of the citrus pest red scale, Aonidiella aurantii (Mask), has been consistently unsuccessful although it is successful in middle altitude regions. However, recent cases of resistance to organophosphate insecticides elsewhere in southern Africa, make it important to reconsider biological control of red scale in the lowlands. Should similar resistance be evolved in this region, the pest could be controlled only by natural means together with oils. This account attempts to answer questions about the natural control of a red scale population in the lowlands, by examining data collected between 1972 and 1975. The population was continuously breeding with overlapped generations. It consisted of three sections, on leaves, twigs and fruit, having different rates of reproduction, development and mortality. These sections are considered separately but that on leaves, being relatively unimportant, is largely ignored. The generation mortality is estimated in the sections on twigs and fruit and related to climatic and biotic indices. The causes of seasonal and between-years variation in the sections on twigs and fruit are elucidated. The effectiveness of each kind of natural enemy is examined and the factors affecting natural enemy numbers are investigated. The question of population regulation is discussed. Differences in mean infestation levels in middle altitude and lowland regions are explained in terms of different rates of reproduction and mortality.
- Full Text:
- Date Issued: 1982
Investigations of the bioavailability/bioequivalence of topical corticosteroid formulations containing clobetasol propionate using the human skin blanching assay, tape stripping and microdialysis
- Authors: Au, Wai Ling
- Date: 2010
- Subjects: Adrenocortical hormones -- Bioavailability , Drugs -- Therapeutic equivalency , Adrenocortical hormones -- Effectiveness , Adrenocortical hormones -- Testing , Adrenocortical hormones -- Side effects , Transdermal medication
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3743 , http://hdl.handle.net/10962/d1003221 , Adrenocortical hormones -- Bioavailability , Drugs -- Therapeutic equivalency , Adrenocortical hormones -- Effectiveness , Adrenocortical hormones -- Testing , Adrenocortical hormones -- Side effects , Transdermal medication
- Description: Currently, clinical trials in patients are required by most regulatory authorities for the assessment of bioequivalence of topical products where the drug is not intended for systemic absorption. Hence there is a dire need for suitable methods for the assessment of bioavailability and bioequivalence of such products since clinical safety and efficacy studies are expensive, time-consuming and require very large numbers of patients. Except for topical corticosteroid products where the human skin blanching assay/vasoconstrictor assay has been approved by the US FDA for bioequivalence assessment of those products, no other method has been “officially” approved for use in those investigations. However, a few alternative methods such as tape stripping and microdialysis have been pursued and considered to have the potential for use in ioequivalence/bioavailability studies. The human skin blanching assay was used to assess the bioequivalence of commercially available topical products containing 0.05% clobetasol propionate. Both visual and chromameter data were obtained and a commercially available topical corticosteroid product, Dermovate® cream was used as both the “Test” and the “Reference” product. The results indicated that both visual and chromametric assessments were comparable to each other and that either could be used for the assessment of the bioequivalence of topical products containing clobetasol propionate. The screening procedure was optimized to identify potential “detectors” for inclusion in the bioequivalence studies. This resulted in fewer subjects being required in a bioequivalence pivotal study, still having the necessary power to confirm bioequivalence using the human skin blanching assay. Another objective of this research was to re-visit tape stripping and other possible alternative methods such as dermal microdialysis and to optimize these procedures for bioequivalence assessment of topical formulations where the drug is not intended for systemic absorption. In the past few decades, tape stripping has been used to investigate bioavailability/bioequivalence of various topical formulations. This technique involves the removal of the stratum corneum to assess drug penetration through the skin. A draft FDA guidance for tape stripping was initially published but was subsequently withdrawn due to high variability and poor reproducibility. This research project used an optimized tape stripping procedure to determine bioavailability and establish bioequivalence between three commercially available formulations containing 0.05 % m/m clobetasol propionate. Furthermore, tape stripping was validated by undertaking a study to assess the bioequivalence of a 0.05% topical cream formulation (Dermovate® cream) using the same cream as both the “Test” and “Reference” product, in which bioequivalence was confirmed. The findings highlight the potential of tape stripping as an alternative method for the assessment of bioequivalence of clobetasol propionate formulations and may possibly be extended for use in other topical products. Microdialysis is another useful technique that can assess the penetration of topically applied substances which diffuses through the stratum corneum and into the dermis. Microdialysis has previously been successfully used for in vivo bioavailability and bioequivalence assessments of topical formulations. However, the drugs which were under investigation were all hydrophilic in nature. A major problem with the use of microdialysis for the assessment of lipophilic substances is the binding/adherence of the substance to the membrane and other components of the microdialysis system. As a result, this necessitates the development of a microdialysis system which can be used to assess lipophilic drugs. Intralipid® 20% was investigated and successfully utilized as a perfusate to recover a lipophilic topical corticosteroid, clobetasol propionate, in microdialysis studies. Hence, the bioavailability of clobetasol propionate from an extemporaneous preparation was determined in healthy human volunteers using microdialysis. These findings indicate that in vivo microdialysis can be used to assess lipophilic drug penetration through the skin. A novel approach to investigate drug release from topical formulations containing 0.05% clobetasol propionate using in vitro microdialysis was also undertaken. The in vitro findings were found to be in agreement with the results obtained using tape stripping to assess bioequivalence of the same commercially available products, namely Dermovate® cream, Dovate® Cream and Dermovate® ointment. These results indicate the potential to correlate in vitro with in vivo data for bioequivalence assessment of such topical dosage forms.
- Full Text:
- Date Issued: 2010
- Authors: Au, Wai Ling
- Date: 2010
- Subjects: Adrenocortical hormones -- Bioavailability , Drugs -- Therapeutic equivalency , Adrenocortical hormones -- Effectiveness , Adrenocortical hormones -- Testing , Adrenocortical hormones -- Side effects , Transdermal medication
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3743 , http://hdl.handle.net/10962/d1003221 , Adrenocortical hormones -- Bioavailability , Drugs -- Therapeutic equivalency , Adrenocortical hormones -- Effectiveness , Adrenocortical hormones -- Testing , Adrenocortical hormones -- Side effects , Transdermal medication
- Description: Currently, clinical trials in patients are required by most regulatory authorities for the assessment of bioequivalence of topical products where the drug is not intended for systemic absorption. Hence there is a dire need for suitable methods for the assessment of bioavailability and bioequivalence of such products since clinical safety and efficacy studies are expensive, time-consuming and require very large numbers of patients. Except for topical corticosteroid products where the human skin blanching assay/vasoconstrictor assay has been approved by the US FDA for bioequivalence assessment of those products, no other method has been “officially” approved for use in those investigations. However, a few alternative methods such as tape stripping and microdialysis have been pursued and considered to have the potential for use in ioequivalence/bioavailability studies. The human skin blanching assay was used to assess the bioequivalence of commercially available topical products containing 0.05% clobetasol propionate. Both visual and chromameter data were obtained and a commercially available topical corticosteroid product, Dermovate® cream was used as both the “Test” and the “Reference” product. The results indicated that both visual and chromametric assessments were comparable to each other and that either could be used for the assessment of the bioequivalence of topical products containing clobetasol propionate. The screening procedure was optimized to identify potential “detectors” for inclusion in the bioequivalence studies. This resulted in fewer subjects being required in a bioequivalence pivotal study, still having the necessary power to confirm bioequivalence using the human skin blanching assay. Another objective of this research was to re-visit tape stripping and other possible alternative methods such as dermal microdialysis and to optimize these procedures for bioequivalence assessment of topical formulations where the drug is not intended for systemic absorption. In the past few decades, tape stripping has been used to investigate bioavailability/bioequivalence of various topical formulations. This technique involves the removal of the stratum corneum to assess drug penetration through the skin. A draft FDA guidance for tape stripping was initially published but was subsequently withdrawn due to high variability and poor reproducibility. This research project used an optimized tape stripping procedure to determine bioavailability and establish bioequivalence between three commercially available formulations containing 0.05 % m/m clobetasol propionate. Furthermore, tape stripping was validated by undertaking a study to assess the bioequivalence of a 0.05% topical cream formulation (Dermovate® cream) using the same cream as both the “Test” and “Reference” product, in which bioequivalence was confirmed. The findings highlight the potential of tape stripping as an alternative method for the assessment of bioequivalence of clobetasol propionate formulations and may possibly be extended for use in other topical products. Microdialysis is another useful technique that can assess the penetration of topically applied substances which diffuses through the stratum corneum and into the dermis. Microdialysis has previously been successfully used for in vivo bioavailability and bioequivalence assessments of topical formulations. However, the drugs which were under investigation were all hydrophilic in nature. A major problem with the use of microdialysis for the assessment of lipophilic substances is the binding/adherence of the substance to the membrane and other components of the microdialysis system. As a result, this necessitates the development of a microdialysis system which can be used to assess lipophilic drugs. Intralipid® 20% was investigated and successfully utilized as a perfusate to recover a lipophilic topical corticosteroid, clobetasol propionate, in microdialysis studies. Hence, the bioavailability of clobetasol propionate from an extemporaneous preparation was determined in healthy human volunteers using microdialysis. These findings indicate that in vivo microdialysis can be used to assess lipophilic drug penetration through the skin. A novel approach to investigate drug release from topical formulations containing 0.05% clobetasol propionate using in vitro microdialysis was also undertaken. The in vitro findings were found to be in agreement with the results obtained using tape stripping to assess bioequivalence of the same commercially available products, namely Dermovate® cream, Dovate® Cream and Dermovate® ointment. These results indicate the potential to correlate in vitro with in vivo data for bioequivalence assessment of such topical dosage forms.
- Full Text:
- Date Issued: 2010
Residents’ perspectives on township tourism in Mondesa, Swakopmund, Namibia
- Auala, Lovisa Sisco Ndapanda
- Authors: Auala, Lovisa Sisco Ndapanda
- Date: 2019
- Subjects: Tourism — Namibia
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/42448 , vital:36661
- Description: Township tourism is regarded as one of the fastest growing tourist activities in Namibia (Buning, Legant, Schauwinhold, Steinbrink & Subenguth, 2016:14). This research study presents an exploratory inquiry that seeks an in-depth understanding of residents’perspectives on township tourism in Mondesa, Swakopmund, Namibia.In order to conceptualise the extent to which the residents’needs are being met through the benefits derived from township tourism. The residents’ perspectives on township tourism in Mondesa areexplored with respect to the benefits and costs derived from township tourism, participation in township tourism, and interaction with tourist during a township tour and consultation on township tourismwhich forms part of the research questions ofthe study. By applying the Social Exchange Theory (SET) in this study, the relationships between the variables that influence the residents perceived benefit and costs of township tourism in Mondesa are explored further in depth in combination with Pretty’s Typology of participation and Scheyne’s typology of community empowerment in tourism (Ap, 1992: 668; Mason, 2003:119; Sharpley and Telfer, 2002:152;Cooper, Fletcher, Gilbert & Wanhill, 1993:91).These variables are namely; social, economic, psychological, environmental, cultural, Manipulative, passive, educational and political factors. They form part of the conceptual framework of the study.This study followed a qualitative research approachandmultiple data sources were collected including semi-structured interviews with residents from Mondesa:these included residents involved in township tourism and those not involved in township tourism. To triangulate the data collection, semi-structured interviews were conducted with representatives from tourism industry and government bodies related to townshiptourism. Data analysis was done through the facilitation of Atlas tiaqualitative data analysis software and deductive codes were established from the literature(variables from the conceptual framework)and themes were developed from the research questions.The findings indicate that residents who are not involved in township tourism arenot influenced by the benefit and cost equation of the social exchange theory (Andriotis, 2005:69). Therefore residents not involved in township tourism are positive about tourism irrespective of whether they benefit directly from financial gain through tourism. The findingsfurtheremphasis oncommunity benefitsfrom township tourism being as important, than individual benefits. This study also provides knowledge that meaningful interaction between tourist and residents has the ability to reduce the apartheid paradigm of racial division and discrimination, which was the basis of the formation of townships.Residents’ misconception about white people are changed due to their personal interaction and cultural exchange with white tourist during a township tour. Anothersignificant findings to emerge from this study is the ability for township tourism to transform the lives of residents living in townships through the intrinsic benefits derived from township tourism. Township tourism has the ability to contribute to positive human exchange through interaction between residents and tourists. By sharing a positive cultural exchange, strong relationships are built between the tourists and residents, which may provide long term sustainability of township tourism. The positive personal transformational effect on residents through interaction with tourists is contributing to residents’ socio-economic well-being. Therefore township tourism has the ability to quantitatively and qualitatively address the alleviationof poverty in townshipsand fostering understanding and mutual respect among peoples of the world.The studyconcluded with a framework of guidelines toaid key stakeholders in the development and planning of township tourism and encourages the practice of sustainable tourism in townships.
- Full Text:
- Date Issued: 2019
- Authors: Auala, Lovisa Sisco Ndapanda
- Date: 2019
- Subjects: Tourism — Namibia
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/42448 , vital:36661
- Description: Township tourism is regarded as one of the fastest growing tourist activities in Namibia (Buning, Legant, Schauwinhold, Steinbrink & Subenguth, 2016:14). This research study presents an exploratory inquiry that seeks an in-depth understanding of residents’perspectives on township tourism in Mondesa, Swakopmund, Namibia.In order to conceptualise the extent to which the residents’needs are being met through the benefits derived from township tourism. The residents’ perspectives on township tourism in Mondesa areexplored with respect to the benefits and costs derived from township tourism, participation in township tourism, and interaction with tourist during a township tour and consultation on township tourismwhich forms part of the research questions ofthe study. By applying the Social Exchange Theory (SET) in this study, the relationships between the variables that influence the residents perceived benefit and costs of township tourism in Mondesa are explored further in depth in combination with Pretty’s Typology of participation and Scheyne’s typology of community empowerment in tourism (Ap, 1992: 668; Mason, 2003:119; Sharpley and Telfer, 2002:152;Cooper, Fletcher, Gilbert & Wanhill, 1993:91).These variables are namely; social, economic, psychological, environmental, cultural, Manipulative, passive, educational and political factors. They form part of the conceptual framework of the study.This study followed a qualitative research approachandmultiple data sources were collected including semi-structured interviews with residents from Mondesa:these included residents involved in township tourism and those not involved in township tourism. To triangulate the data collection, semi-structured interviews were conducted with representatives from tourism industry and government bodies related to townshiptourism. Data analysis was done through the facilitation of Atlas tiaqualitative data analysis software and deductive codes were established from the literature(variables from the conceptual framework)and themes were developed from the research questions.The findings indicate that residents who are not involved in township tourism arenot influenced by the benefit and cost equation of the social exchange theory (Andriotis, 2005:69). Therefore residents not involved in township tourism are positive about tourism irrespective of whether they benefit directly from financial gain through tourism. The findingsfurtheremphasis oncommunity benefitsfrom township tourism being as important, than individual benefits. This study also provides knowledge that meaningful interaction between tourist and residents has the ability to reduce the apartheid paradigm of racial division and discrimination, which was the basis of the formation of townships.Residents’ misconception about white people are changed due to their personal interaction and cultural exchange with white tourist during a township tour. Anothersignificant findings to emerge from this study is the ability for township tourism to transform the lives of residents living in townships through the intrinsic benefits derived from township tourism. Township tourism has the ability to contribute to positive human exchange through interaction between residents and tourists. By sharing a positive cultural exchange, strong relationships are built between the tourists and residents, which may provide long term sustainability of township tourism. The positive personal transformational effect on residents through interaction with tourists is contributing to residents’ socio-economic well-being. Therefore township tourism has the ability to quantitatively and qualitatively address the alleviationof poverty in townshipsand fostering understanding and mutual respect among peoples of the world.The studyconcluded with a framework of guidelines toaid key stakeholders in the development and planning of township tourism and encourages the practice of sustainable tourism in townships.
- Full Text:
- Date Issued: 2019