A comparative analysis of the taxation of lease transactions in South Africa, Australia, and Nigeria
- Authors: Galada, Khayalethu
- Date: 2021-04
- Subjects: Tax accounting -- South Africa , Tax accounting -- Australia , Tax accounting -- Nigeria , Taxation -- South Africa Taxation -- Australia Taxation -- Nigeria Accounting
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/51428 , vital:43274
- Description: This treatise compared the tax treatment of lease transactions in South Africa, Australia, and Nigeria from both the lessor and lessee perspective. The analysis revealed that there are similarities and differences in the tax treatment of lease transactions between South Africa, Australia, and Nigeria. In particular, one major difference was that unlike Nigeria, South Africa and Australia have not aligned the income tax treatment of lease transactions with the accounting treatment of lease transactions in terms of IFRS 16. Consequently, the research concludes that certain parts of the tax treatment of lease transactions in South Africa may be deemed to be inadequate as a result of the misalignment between the income tax and accounting treatment of lease transactions and the inconsistency between the income tax and VAT treatment of lease transactions. This research proposes that the South African income tax treatment of lease transactions be revised by aligning the income tax treatment of lease transactions with the accounting treatment of lease transactions for simplicity purposes, and that the inconsistency between the income tax treatment and the value-added tax of lease transactions be eliminated. , Thesis (MCom) -- Faculty of Business and Economic Sciences, Accounting, 2021
- Full Text:
- Date Issued: 2021-04
A comparative analysis of the taxation of lease transactions in South Africa, Australia, and Nigeria
- Authors: Galada, Khayalethu
- Date: 2021-04
- Subjects: Tax accounting -- South Africa , Tax accounting -- Australia , Tax accounting -- Nigeria , Taxation -- South Africa Taxation -- Australia Taxation -- Nigeria Accounting
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/51428 , vital:43274
- Description: This treatise compared the tax treatment of lease transactions in South Africa, Australia, and Nigeria from both the lessor and lessee perspective. The analysis revealed that there are similarities and differences in the tax treatment of lease transactions between South Africa, Australia, and Nigeria. In particular, one major difference was that unlike Nigeria, South Africa and Australia have not aligned the income tax treatment of lease transactions with the accounting treatment of lease transactions in terms of IFRS 16. Consequently, the research concludes that certain parts of the tax treatment of lease transactions in South Africa may be deemed to be inadequate as a result of the misalignment between the income tax and accounting treatment of lease transactions and the inconsistency between the income tax and VAT treatment of lease transactions. This research proposes that the South African income tax treatment of lease transactions be revised by aligning the income tax treatment of lease transactions with the accounting treatment of lease transactions for simplicity purposes, and that the inconsistency between the income tax treatment and the value-added tax of lease transactions be eliminated. , Thesis (MCom) -- Faculty of Business and Economic Sciences, Accounting, 2021
- Full Text:
- Date Issued: 2021-04
A comparative appraisal of access and quality of sexual and reproductive health services for gays and lesbians in Bulawayo (Zimbabwe) and Pretoria (South Africa)
- Authors: Jasi, Phineas
- Date: 2021-11
- Subjects: Reproductive health , Sexual health
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/21959 , vital:51854
- Description: This study investigated the extent to which gays and lesbians access quality sexual and reproductive health (SRH) services in Pretoria and Bulawayo. The study also examines the facilitators and barriers for accessing the same services. Theoretically, the study was grounded in the Health Belief Model (Hochbaum, 1958, modified by Rosenstock, 1974 and Siddiqui, 2016). To answer the research questions, a mixed methods approach was applied involving both qualitative and quantitative data collection methods. A total of 30 key informant interviews, eight focus group discussions and 387 questionnaires were administered using purposive, time location and snowball sampling approaches in the two cities. The study found that the most commonly available sexual and reproductive health (SRH) services were contraceptive services, sexually transmitted infections (STI) services and Human immunodeficiency syndrome (HIV) services. The services were provided at public health facilities, drop-in centres and through outreach activities operated by Civil Society Organizations (CSOs). The least available services that gays and lesbians required as part of a comprehensive package were access to information, education and communications (IEC) materials and mental health and psychosocial support services (MHPSS). Several service providers were not adhering to the World Health Organization (WHO) guidelines for provision of comprehensive services for key populations including gays and lesbians. Critical gaps noted included the absence of key populations-only service hours, lack of options for clinicians to attend to them, presence of a stigma and discrimination free environment and provision of comprehensive package of services under one roof. Most of the referral facilities had limited drugs, equipment and supplies for cancer screening and they had no HIV prevention, sex change, in-vitro fertilization, and sterilization services and procedures. The quality of physical facilities and SRH services in both cities did not meet the expectations of gays and lesbians, acting as a barrier to their health seeking behaviour. Stigma and discrimination from healthcare workers was a huge barrier affecting access across all public health facilities. The acts of stigmatisation and discrimination affected the perceptions that gays and lesbians had regarding the quality of the services and compromised access of the same. In view of these health system challenges, the study recommends that there is need for public authorities in both cities to address the bottlenecks and barriers affecting access to SRH services and products such as lubricants, affordable quality condoms, dental dams and latex gloves while reinforcing the facilitating factors promoting access. Healthcare workers need further training on how to provide comprehensive services for gays and lesbians according to the WHO guidelines. Public health authorities in Bulawayo and Pretoria should build upon the identified factors which facilitated the access to SRH services and use of products such as condoms and lubricants. These factors require strengthening of community-based organizations and networks that work directly with gays and lesbians in both Bulawayo and Pretoria. , Thesis (PhD) -- Faculty of Social Sciences and Humanities, 2021
- Full Text:
- Date Issued: 2021-11
- Authors: Jasi, Phineas
- Date: 2021-11
- Subjects: Reproductive health , Sexual health
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/21959 , vital:51854
- Description: This study investigated the extent to which gays and lesbians access quality sexual and reproductive health (SRH) services in Pretoria and Bulawayo. The study also examines the facilitators and barriers for accessing the same services. Theoretically, the study was grounded in the Health Belief Model (Hochbaum, 1958, modified by Rosenstock, 1974 and Siddiqui, 2016). To answer the research questions, a mixed methods approach was applied involving both qualitative and quantitative data collection methods. A total of 30 key informant interviews, eight focus group discussions and 387 questionnaires were administered using purposive, time location and snowball sampling approaches in the two cities. The study found that the most commonly available sexual and reproductive health (SRH) services were contraceptive services, sexually transmitted infections (STI) services and Human immunodeficiency syndrome (HIV) services. The services were provided at public health facilities, drop-in centres and through outreach activities operated by Civil Society Organizations (CSOs). The least available services that gays and lesbians required as part of a comprehensive package were access to information, education and communications (IEC) materials and mental health and psychosocial support services (MHPSS). Several service providers were not adhering to the World Health Organization (WHO) guidelines for provision of comprehensive services for key populations including gays and lesbians. Critical gaps noted included the absence of key populations-only service hours, lack of options for clinicians to attend to them, presence of a stigma and discrimination free environment and provision of comprehensive package of services under one roof. Most of the referral facilities had limited drugs, equipment and supplies for cancer screening and they had no HIV prevention, sex change, in-vitro fertilization, and sterilization services and procedures. The quality of physical facilities and SRH services in both cities did not meet the expectations of gays and lesbians, acting as a barrier to their health seeking behaviour. Stigma and discrimination from healthcare workers was a huge barrier affecting access across all public health facilities. The acts of stigmatisation and discrimination affected the perceptions that gays and lesbians had regarding the quality of the services and compromised access of the same. In view of these health system challenges, the study recommends that there is need for public authorities in both cities to address the bottlenecks and barriers affecting access to SRH services and products such as lubricants, affordable quality condoms, dental dams and latex gloves while reinforcing the facilitating factors promoting access. Healthcare workers need further training on how to provide comprehensive services for gays and lesbians according to the WHO guidelines. Public health authorities in Bulawayo and Pretoria should build upon the identified factors which facilitated the access to SRH services and use of products such as condoms and lubricants. These factors require strengthening of community-based organizations and networks that work directly with gays and lesbians in both Bulawayo and Pretoria. , Thesis (PhD) -- Faculty of Social Sciences and Humanities, 2021
- Full Text:
- Date Issued: 2021-11
A comparative photophysicochemical study of mono substituted phthalocyanines grafted onto silica nanoparticles
- Fashina, Adebayo, Antunes, Edith M, Nyokong, Tebello
- Authors: Fashina, Adebayo , Antunes, Edith M , Nyokong, Tebello
- Date: 2014
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/193844 , vital:45399 , xlink:href="https://doi.org/10.1142/S1088424614500138"
- Description: In this study, we report on the covalent linking of carboxylic acid functionalized silica nanoparticles with zinc phthalocyanine mono-substituted non-peripherally and peripherally with either a 4-amino phenoxy (1, peripheral and 2, non-peripheral) or an amino group (3 peripheral). The grafting is achieved via the formation of an amide bond between the carboxylic acid of the silica nanoparticles and the amino group of the phthalocyanine complexes. The hybrid nanoparticles retained the amorphous nature of silica nanoparticles after conjugation. A slight decrease in fluorescence and a general improvement in triplet quantum yields compared to free Pcs were observed. Triplet lifetimes for 2-SiNPs and 3-SiNPs also improved when compared to the free phthalocyanine. The changes in singlet oxygen quantum yields upon conjugation were minimal.
- Full Text:
- Date Issued: 2014
- Authors: Fashina, Adebayo , Antunes, Edith M , Nyokong, Tebello
- Date: 2014
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/193844 , vital:45399 , xlink:href="https://doi.org/10.1142/S1088424614500138"
- Description: In this study, we report on the covalent linking of carboxylic acid functionalized silica nanoparticles with zinc phthalocyanine mono-substituted non-peripherally and peripherally with either a 4-amino phenoxy (1, peripheral and 2, non-peripheral) or an amino group (3 peripheral). The grafting is achieved via the formation of an amide bond between the carboxylic acid of the silica nanoparticles and the amino group of the phthalocyanine complexes. The hybrid nanoparticles retained the amorphous nature of silica nanoparticles after conjugation. A slight decrease in fluorescence and a general improvement in triplet quantum yields compared to free Pcs were observed. Triplet lifetimes for 2-SiNPs and 3-SiNPs also improved when compared to the free phthalocyanine. The changes in singlet oxygen quantum yields upon conjugation were minimal.
- Full Text:
- Date Issued: 2014
A comparative photophysicochemical study of phthalocyanines encapsulated in core–shell silica nanoparticles
- Fashina, Adedayo, Amuhaya, Edith, Nyokong, Tebello
- Authors: Fashina, Adedayo , Amuhaya, Edith , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189708 , vital:44924 , xlink:href="https://doi.org/10.1016/j.saa.2014.08.062"
- Description: This work presents the synthesis and characterization of a new zinc phthalocyanine complex tetrasubstituted with 3-carboxyphenoxy in the peripheral position. The photophysical properties of the new complex are compared with those of phthalocyanines tetra substituted with 3-carboxyphenoxy or 4- carboxyphenoxy at non-peripheral positions. Three phthalocyanine complexes were encapsulated within silica matrix to form a core shell and the hybrid nanoparticles particles obtained were spherical and mono dispersed. When encapsulated within the silica shell nanoparticles, phthalocyanines showed improved triplet quantum yields and singlet oxygen quantum yields than surface grafted derivatives. The improvements observed could be attributed to the protection provided for the phthalocyanine complexes by the silica matrix.
- Full Text:
- Date Issued: 2015
- Authors: Fashina, Adedayo , Amuhaya, Edith , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189708 , vital:44924 , xlink:href="https://doi.org/10.1016/j.saa.2014.08.062"
- Description: This work presents the synthesis and characterization of a new zinc phthalocyanine complex tetrasubstituted with 3-carboxyphenoxy in the peripheral position. The photophysical properties of the new complex are compared with those of phthalocyanines tetra substituted with 3-carboxyphenoxy or 4- carboxyphenoxy at non-peripheral positions. Three phthalocyanine complexes were encapsulated within silica matrix to form a core shell and the hybrid nanoparticles particles obtained were spherical and mono dispersed. When encapsulated within the silica shell nanoparticles, phthalocyanines showed improved triplet quantum yields and singlet oxygen quantum yields than surface grafted derivatives. The improvements observed could be attributed to the protection provided for the phthalocyanine complexes by the silica matrix.
- Full Text:
- Date Issued: 2015
A comparative physicochemical study of unsymmetrical indium phthalocyanines in the presence of magnetic nanoparticles or quantum dots
- Osifeko, Olawale L, Nyokong, Tebello
- Authors: Osifeko, Olawale L , Nyokong, Tebello
- Date: 2016
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/188743 , vital:44781 , xlink:href="https://doi.org/10.1080/00958972.2016.1152628"
- Description: Asymmetric indium phthalocyanine (3, containing an NH2 group) was conjugated (via an amide bond) to magnetic nanoparticle (MNP) functionalized with carboxylic acid or glutathione-capped CdTe/ZnSe/ZnO quantum dots to form 3-MNPs or 3-QDs. Techniques such as time-resolved fluorescence measurements, transmission electron microscopy, XPS, elemental analysis, FTIR, NMR (1H, 13C, and cozy), electronic spectroscopy, as well as mass spectroscopy were employed to characterize 3 and its nanoconjugates. The phthalocyanine conjugated to quantum dot (3-QDs) possesses the lowest Фpd higher Ф∆ and ФT as well as longer triplet lifetimes compares to 3-MNPs and free phthalocyanine.
- Full Text:
- Date Issued: 2016
- Authors: Osifeko, Olawale L , Nyokong, Tebello
- Date: 2016
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/188743 , vital:44781 , xlink:href="https://doi.org/10.1080/00958972.2016.1152628"
- Description: Asymmetric indium phthalocyanine (3, containing an NH2 group) was conjugated (via an amide bond) to magnetic nanoparticle (MNP) functionalized with carboxylic acid or glutathione-capped CdTe/ZnSe/ZnO quantum dots to form 3-MNPs or 3-QDs. Techniques such as time-resolved fluorescence measurements, transmission electron microscopy, XPS, elemental analysis, FTIR, NMR (1H, 13C, and cozy), electronic spectroscopy, as well as mass spectroscopy were employed to characterize 3 and its nanoconjugates. The phthalocyanine conjugated to quantum dot (3-QDs) possesses the lowest Фpd higher Ф∆ and ФT as well as longer triplet lifetimes compares to 3-MNPs and free phthalocyanine.
- Full Text:
- Date Issued: 2016
A comparative study of multiculturalism in South Africa and Canada: evaluating successes and failures.
- Authors: Anele Mngadi
- Date: 2022-12
- Subjects: Race discrimination -- Economic aspects – South Africa , Social justice -- South Africa , Xenophobia
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59435 , vital:62114
- Description: The purpose of this study was to evaluate the successes and failures of multiculturalism in South Africa and Canada through the lens of critical multiculturalism as its theoretical frame. As Canada is widely-acknowledged as having one of the best multiculturalism policy and implementation programmes in the world, this study aimed to draw lessons from the Canadian model of multiculturalism in order to make recommendations to improve multicultural practices in South Africa. It is worth noting that multiculturalism in Canada is not perfect as government still struggles to implement inclusive and reconciliatory programmes for the previously colonised Indigenous communities. This study used a qualitative thematic analysis to enable a comparison of multiculturalism in these two countries. The findings of this study suggest that having a comprehensive multiculturalism policy is fundamental to ensure that aspirations of a socially cohesive multiculturalism are not merely philosophical, but are formulated into government policies, with guidelines for implementation through the guidance of critical multiculturalism theory. The findings of this study also suggest that the persistent racialised socio-economic inequalities in South Africa continue to undermine multiculturalism and nation-building efforts. , Thesis (MA) -- Faculty of Humanities, School of Governmental and Social Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Anele Mngadi
- Date: 2022-12
- Subjects: Race discrimination -- Economic aspects – South Africa , Social justice -- South Africa , Xenophobia
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59435 , vital:62114
- Description: The purpose of this study was to evaluate the successes and failures of multiculturalism in South Africa and Canada through the lens of critical multiculturalism as its theoretical frame. As Canada is widely-acknowledged as having one of the best multiculturalism policy and implementation programmes in the world, this study aimed to draw lessons from the Canadian model of multiculturalism in order to make recommendations to improve multicultural practices in South Africa. It is worth noting that multiculturalism in Canada is not perfect as government still struggles to implement inclusive and reconciliatory programmes for the previously colonised Indigenous communities. This study used a qualitative thematic analysis to enable a comparison of multiculturalism in these two countries. The findings of this study suggest that having a comprehensive multiculturalism policy is fundamental to ensure that aspirations of a socially cohesive multiculturalism are not merely philosophical, but are formulated into government policies, with guidelines for implementation through the guidance of critical multiculturalism theory. The findings of this study also suggest that the persistent racialised socio-economic inequalities in South Africa continue to undermine multiculturalism and nation-building efforts. , Thesis (MA) -- Faculty of Humanities, School of Governmental and Social Sciences, 2022
- Full Text:
- Date Issued: 2022-12
A comparative study of occupational hazards amongst public hospital healthcare workers in urban and rural areas of KwaZulu Natal, South Africa
- Authors: Ngobe, Sinoneliso Avuyisiwe
- Date: 2021-04
- Subjects: Community health services , Health risk assessment -- South Africa , Hazardous materials-- KwaZulu Natal
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/56081 , vital:55291
- Description: The role of healthcare workers (HCWs) is to render services to the sick. While executing their duties, these HCWs can fall ill due to various occupational exposures. HCWs are exposed to a range of hazards including physical, biological, chemical and ergonomic hazards. These hazards can cause physical injuries, diseases, mental strain and other adverse health effects.: The aim of this study was to assess the prevalence of occupational hazards amongst HCWs in urban and rural areas of the KwaZulu-Natal province, South Africa: A descriptive cross-sectional research design was utilised on the estimated sample size of 270 respondents, from ten public hospitals. The sampling method used to identify participants was convenience sampling and data was collected through a self-administered, semi-structured questionnaire. The analysed data was presented in descriptive and inferential summary statistics. The data was analysed using graphical and numerical descriptive statistics as well as inferential statistical techniques. The statistical significance was set at P0.05. The results revealed that both urban and rural HCWs were exposed to physical, biological, chemical and ergonomic hazards. Overall, physical hazards were the most frequently reported form of hazard exposure at 98,6%, followed by biological hazards (96,7%), ergonomic hazards (94,4%) and chemical hazards (23,7%). The duration of exposure to hazards varied from 12 months to 5 years. In a period of 12 months, radiation, cold, heat, slips and trips were the most common sources of physical hazard exposure while direct contact with patient bodily fluids was the most common source of biological hazard exposure and mercury was the most common source of chemical hazard exposure. More than a quarter of the HCWs had experienced some form of assault by a patient in the preceding 12 months. Over a three-year period, both urban and rural area HCWs reported the use of post-exposure prophylaxis and experienced symptoms of chemical exposure at work. Less than 6% of the HCWs had developed an occupational disease in the previous five years. There were no statistically significant differences in total exposure to hazards between urban and rural area HCW. , Thesis (Mtech) --Faculty of Health Sciences, School of Behavioural Sciences, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Ngobe, Sinoneliso Avuyisiwe
- Date: 2021-04
- Subjects: Community health services , Health risk assessment -- South Africa , Hazardous materials-- KwaZulu Natal
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/56081 , vital:55291
- Description: The role of healthcare workers (HCWs) is to render services to the sick. While executing their duties, these HCWs can fall ill due to various occupational exposures. HCWs are exposed to a range of hazards including physical, biological, chemical and ergonomic hazards. These hazards can cause physical injuries, diseases, mental strain and other adverse health effects.: The aim of this study was to assess the prevalence of occupational hazards amongst HCWs in urban and rural areas of the KwaZulu-Natal province, South Africa: A descriptive cross-sectional research design was utilised on the estimated sample size of 270 respondents, from ten public hospitals. The sampling method used to identify participants was convenience sampling and data was collected through a self-administered, semi-structured questionnaire. The analysed data was presented in descriptive and inferential summary statistics. The data was analysed using graphical and numerical descriptive statistics as well as inferential statistical techniques. The statistical significance was set at P0.05. The results revealed that both urban and rural HCWs were exposed to physical, biological, chemical and ergonomic hazards. Overall, physical hazards were the most frequently reported form of hazard exposure at 98,6%, followed by biological hazards (96,7%), ergonomic hazards (94,4%) and chemical hazards (23,7%). The duration of exposure to hazards varied from 12 months to 5 years. In a period of 12 months, radiation, cold, heat, slips and trips were the most common sources of physical hazard exposure while direct contact with patient bodily fluids was the most common source of biological hazard exposure and mercury was the most common source of chemical hazard exposure. More than a quarter of the HCWs had experienced some form of assault by a patient in the preceding 12 months. Over a three-year period, both urban and rural area HCWs reported the use of post-exposure prophylaxis and experienced symptoms of chemical exposure at work. Less than 6% of the HCWs had developed an occupational disease in the previous five years. There were no statistically significant differences in total exposure to hazards between urban and rural area HCW. , Thesis (Mtech) --Faculty of Health Sciences, School of Behavioural Sciences, 2021
- Full Text:
- Date Issued: 2021-04
A comparative study of the effect of different stabilizers on the critical quality attributes of self-assembling nano co-crystals
- Witika, Bwalya A, Smith, Vincent J, Walker, Roderick B
- Authors: Witika, Bwalya A , Smith, Vincent J , Walker, Roderick B
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/183224 , vital:43931 , xlink:href=" https://doi.org/10.3390/pharmaceutics12020182"
- Description: Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used orally to manage HIV/AIDS infection. A pseudo one-solvent bottom-up approach was used to develop and produce nano co-crystals of 3TC and AZT. Equimolar amounts of 3TC dissolved in de-ionized water and AZT in methanol were rapidly injected into a pre-cooled vessel and sonicated at 4 °C. The resultant suspensions were characterized using a Zetasizer. The particle size, polydispersity index and Zeta potential were elucidated. Further characterization was undertaken using powder X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and energy dispersive X-ray spectroscopy scanning electron microscopy. Different surfactants were assessed for their ability to stabilize the nano co-crystals and for their ability to produce nano co-crystals with specific and desirable critical quality attributes (CQA) including particle size (PS) less than 1000 nm, polydispersity index (PDI) less than 0.500 and Zeta potential (ZP) less than −30 mV. All surfactants produced co-crystals in the nanometer range. The PDI and PS are concentration-dependent for all nano co-crystals manufactured while only ZP was within specification when sodium dodecyl sulfate was used in the process.
- Full Text:
- Date Issued: 2020
- Authors: Witika, Bwalya A , Smith, Vincent J , Walker, Roderick B
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/183224 , vital:43931 , xlink:href=" https://doi.org/10.3390/pharmaceutics12020182"
- Description: Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used orally to manage HIV/AIDS infection. A pseudo one-solvent bottom-up approach was used to develop and produce nano co-crystals of 3TC and AZT. Equimolar amounts of 3TC dissolved in de-ionized water and AZT in methanol were rapidly injected into a pre-cooled vessel and sonicated at 4 °C. The resultant suspensions were characterized using a Zetasizer. The particle size, polydispersity index and Zeta potential were elucidated. Further characterization was undertaken using powder X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and energy dispersive X-ray spectroscopy scanning electron microscopy. Different surfactants were assessed for their ability to stabilize the nano co-crystals and for their ability to produce nano co-crystals with specific and desirable critical quality attributes (CQA) including particle size (PS) less than 1000 nm, polydispersity index (PDI) less than 0.500 and Zeta potential (ZP) less than −30 mV. All surfactants produced co-crystals in the nanometer range. The PDI and PS are concentration-dependent for all nano co-crystals manufactured while only ZP was within specification when sodium dodecyl sulfate was used in the process.
- Full Text:
- Date Issued: 2020
A comparative study of the photophysicochemical and photodynamic activity properties of meso-4-methylthiophenyl functionalized Sn (IV) tetraarylporphyrins and triarylcorroles
- Dingiswayo, Somila, Babu, Balaji, Prinsloo, Earl, Mack, John, Nyokong, Tebello
- Authors: Dingiswayo, Somila , Babu, Balaji , Prinsloo, Earl , Mack, John , Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186157 , vital:44469 , xlink:href="https://doi.org/10.1142/S1088424620500273"
- Description: Tin(IV) complexes of a 4-methylthiophenyl functionalized porphyrin (1-Sn) and its corrole analogue (2-Sn) were synthesized so that their photophysicochemical properties and photodynamic activities against MCF-7 breast cancer cells could be compared. Singlet oxygen luminescence studies revealed that 1-Sn and 2-Sn have comparable ΦΔΦΔ values in DMF of 0.59 and 0.60, respectively, while the IC5050 values after irradiation of MCF-7 cells for 30 min with a Thorlabs 625 nm LED (432 J · cm−2)−2) were determined to be 12.4 and 8.9 μμM. The results demonstrate that the cellular uptake of 2-Sn and its molar absorptivity at the irradiation wavelength play a crucial role during in vitro cytotoxicity studies.
- Full Text:
- Date Issued: 2020
- Authors: Dingiswayo, Somila , Babu, Balaji , Prinsloo, Earl , Mack, John , Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186157 , vital:44469 , xlink:href="https://doi.org/10.1142/S1088424620500273"
- Description: Tin(IV) complexes of a 4-methylthiophenyl functionalized porphyrin (1-Sn) and its corrole analogue (2-Sn) were synthesized so that their photophysicochemical properties and photodynamic activities against MCF-7 breast cancer cells could be compared. Singlet oxygen luminescence studies revealed that 1-Sn and 2-Sn have comparable ΦΔΦΔ values in DMF of 0.59 and 0.60, respectively, while the IC5050 values after irradiation of MCF-7 cells for 30 min with a Thorlabs 625 nm LED (432 J · cm−2)−2) were determined to be 12.4 and 8.9 μμM. The results demonstrate that the cellular uptake of 2-Sn and its molar absorptivity at the irradiation wavelength play a crucial role during in vitro cytotoxicity studies.
- Full Text:
- Date Issued: 2020
A comparative study of the singlet oxygen generation capability of a zinc phthalocyanine linked to graphene quantum dots through π-π stacking and covalent conjugation when embedded in asymmetric polymer membranes
- Mafukidze, Donovan M, Nyokong, Tebello
- Authors: Mafukidze, Donovan M , Nyokong, Tebello
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/187461 , vital:44655 , xlink:href="https://doi.org/10.1016/j.molstruc.2018.11.096"
- Description: Following the establishment of graphene quantum dots as potential phthalocyanine supports in photoactive membrane preparation for phthalocyanines lacking linkage functional groups, the practical efficiency of p-p stacking versus covalent linkage was investigated. Synthesized materials were characterized using FT-IR, Raman, powder X-ray diffraction, and UVeVis spectroscopies and also by transmission electron and scanning electron microscopies. Phthalocyanine loadings onto graphene quantum dots of 0.40 mg/mg and 0.14 mg/mg (Pc mass/conjugate mass) for the p-p stacked and covalent linked conjugates respectively were observed. Covalent linkage to graphene quantum dots proved to be functionally superior to p-p linkage, where singlet oxygen quantum yield value of the phthalocyanine in the membrane for the covalent linked conjugate was approximately twice that of the p-p stacked membrane.
- Full Text:
- Date Issued: 2019
- Authors: Mafukidze, Donovan M , Nyokong, Tebello
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/187461 , vital:44655 , xlink:href="https://doi.org/10.1016/j.molstruc.2018.11.096"
- Description: Following the establishment of graphene quantum dots as potential phthalocyanine supports in photoactive membrane preparation for phthalocyanines lacking linkage functional groups, the practical efficiency of p-p stacking versus covalent linkage was investigated. Synthesized materials were characterized using FT-IR, Raman, powder X-ray diffraction, and UVeVis spectroscopies and also by transmission electron and scanning electron microscopies. Phthalocyanine loadings onto graphene quantum dots of 0.40 mg/mg and 0.14 mg/mg (Pc mass/conjugate mass) for the p-p stacked and covalent linked conjugates respectively were observed. Covalent linkage to graphene quantum dots proved to be functionally superior to p-p linkage, where singlet oxygen quantum yield value of the phthalocyanine in the membrane for the covalent linked conjugate was approximately twice that of the p-p stacked membrane.
- Full Text:
- Date Issued: 2019
A comparative study on the sensitive detection of hydroxyl radical using thiol-capped CdTe and CdTe/ZnS quantum dots
- Adegoke, Oluwasesan, Nyokong, Tebello
- Authors: Adegoke, Oluwasesan , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/242778 , vital:51077 , xlink:href="https://doi.org/10.1007/s10895-012-1089-2"
- Description: Four types of water-soluble luminescent quantum dots (QDs) whose surface was functionlaized with thioglycolic acid (TGA), 3-mercaptopropionic acid (MPA), or glutathione (GSH), were investigated for the sensitive and selective detection of hydroxyl radical (●OH) in aqueous media. It was found that the type of capping agent and QD influenced the sensitivity of the probe. The order of sensitivity of the probe was: GSH-CdTe@ZnS > MPA-CdTe@ZnS > TGA-CdTe > MPA-CdTe QDs. Under the optimum conditions, a limit of detection as low as 8.5 × 10-8 M was obtained using GSH-CdTe@ZnS. The effects of foreign reactive oxygen species and the Fenton reactants and products as possible interferences on the proposed probe were negligible for CdTe@ZnS QDs. Besides, experimental results indicated that CdTe@ZnS QDs were more attractive for the selective recognition of ●OH than CdTe QDs. The mechanistic reaction pathway between the QDs and ●OH is proposed.
- Full Text:
- Date Issued: 2012
- Authors: Adegoke, Oluwasesan , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/242778 , vital:51077 , xlink:href="https://doi.org/10.1007/s10895-012-1089-2"
- Description: Four types of water-soluble luminescent quantum dots (QDs) whose surface was functionlaized with thioglycolic acid (TGA), 3-mercaptopropionic acid (MPA), or glutathione (GSH), were investigated for the sensitive and selective detection of hydroxyl radical (●OH) in aqueous media. It was found that the type of capping agent and QD influenced the sensitivity of the probe. The order of sensitivity of the probe was: GSH-CdTe@ZnS > MPA-CdTe@ZnS > TGA-CdTe > MPA-CdTe QDs. Under the optimum conditions, a limit of detection as low as 8.5 × 10-8 M was obtained using GSH-CdTe@ZnS. The effects of foreign reactive oxygen species and the Fenton reactants and products as possible interferences on the proposed probe were negligible for CdTe@ZnS QDs. Besides, experimental results indicated that CdTe@ZnS QDs were more attractive for the selective recognition of ●OH than CdTe QDs. The mechanistic reaction pathway between the QDs and ●OH is proposed.
- Full Text:
- Date Issued: 2012
A comparison of anthropogenic and elephant disturbance on Acacia xanthophloea (fever tree) populations in the Lowveld, South Africa
- Botha, Jenny, Witkowski, Ed T F, Shackleton, Charlie M
- Authors: Botha, Jenny , Witkowski, Ed T F , Shackleton, Charlie M
- Date: 2002
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/181629 , vital:43753 , xlink:href="https://doi.org/10.4102/koedoe.v45i1.10"
- Description: Acacia xanthophloea (the ‘fever tree’) is a popular medicinal species that is traded widely in South Africa. Although it occurs throughout southern Africa, there is increasing pressure on its riverine and marshy habitats. This study compares the impact of harvesting on an A. xanthophloea population located on private land near Komatipoort, Mpumalanga, with two protected populations situated within the Kruger National Park. The densities of the harvested and protected populations were similar (84±8 trees/ha and 85±20 trees/ha, respectively). There were fluctuations in the quotients between frequencies of trees in successive diameter classes, which is common in savanna where high levels of fire, mega-herbivore and anthropogenic disturbance are experienced. The extent of stem damage (stripping of bark and breakage) by elephants in the protected area was significantly higher than the extent of harvesting on private land, although the degree of damage was relatively low, with only 7 % of the populations having been damaged at rates >26 %. The degree of harvesting on private land was relatively low, with the majority of trees having been harvested at rates of less than 10 % of the stem below 2 m. Despite this, ringbarking had occurred (4 %). The basal diameters and heights were significantly lower in the protected population than in the harvested one, suggesting that over time elephant impact was the more severe disturbance. Acacia xanthophloea exhibited high resilience to disturbance, with all the elephant damaged trees and harvested individuals surviving. However, the mean bark thickness measured in local markets (6.3±1.4 mm) was significantly lower than that measured in either the harvested (12.4±1.0 mm) or the KNP (10.3±0.8 mm) populations. As harvesters tend to select the largest individuals in a population to maximise their financial returns, this could mean that smaller individuals are being harvested, and/or bark is not being given sufficient time to grow back after harvesting. Acacia xanthophloea outside protected areas thus need to be monitored and the management improved, preferably in conjunction with the resource users. In addition, traditional healers, those selling medicinal plants and other members of the community need to continue to be encouraged to cultivate this fast growing species.
- Full Text:
- Date Issued: 2002
- Authors: Botha, Jenny , Witkowski, Ed T F , Shackleton, Charlie M
- Date: 2002
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/181629 , vital:43753 , xlink:href="https://doi.org/10.4102/koedoe.v45i1.10"
- Description: Acacia xanthophloea (the ‘fever tree’) is a popular medicinal species that is traded widely in South Africa. Although it occurs throughout southern Africa, there is increasing pressure on its riverine and marshy habitats. This study compares the impact of harvesting on an A. xanthophloea population located on private land near Komatipoort, Mpumalanga, with two protected populations situated within the Kruger National Park. The densities of the harvested and protected populations were similar (84±8 trees/ha and 85±20 trees/ha, respectively). There were fluctuations in the quotients between frequencies of trees in successive diameter classes, which is common in savanna where high levels of fire, mega-herbivore and anthropogenic disturbance are experienced. The extent of stem damage (stripping of bark and breakage) by elephants in the protected area was significantly higher than the extent of harvesting on private land, although the degree of damage was relatively low, with only 7 % of the populations having been damaged at rates >26 %. The degree of harvesting on private land was relatively low, with the majority of trees having been harvested at rates of less than 10 % of the stem below 2 m. Despite this, ringbarking had occurred (4 %). The basal diameters and heights were significantly lower in the protected population than in the harvested one, suggesting that over time elephant impact was the more severe disturbance. Acacia xanthophloea exhibited high resilience to disturbance, with all the elephant damaged trees and harvested individuals surviving. However, the mean bark thickness measured in local markets (6.3±1.4 mm) was significantly lower than that measured in either the harvested (12.4±1.0 mm) or the KNP (10.3±0.8 mm) populations. As harvesters tend to select the largest individuals in a population to maximise their financial returns, this could mean that smaller individuals are being harvested, and/or bark is not being given sufficient time to grow back after harvesting. Acacia xanthophloea outside protected areas thus need to be monitored and the management improved, preferably in conjunction with the resource users. In addition, traditional healers, those selling medicinal plants and other members of the community need to continue to be encouraged to cultivate this fast growing species.
- Full Text:
- Date Issued: 2002
A comparison of ethical models for conflict resolution in the African context
- Authors: Mbangu, Muyingi
- Date: 2008
- Subjects: Africa -- Politics and government , Conflict management
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/25052 , vital:63948
- Description: Remarkably little research has been done about the potential of ethical models for violent conflict resolution in the African context. I will argue here that ethical models such as Utilitarianism, Deontologism, Virtue ethics, and African ethics can exert influence to help resolve conflict situations peacefully for the sake of African civilians generally and the DRC civilians in particular. This influence firstly becomes visible in the fact that ethical models can guide conflict resolution attempts to bring about conditions of peace, justice and freedom among African civilians in whichever nations state they find themselves. Secondly, ethical models can be established in the resolution of conflict for a lasting peace in the African context, and lastly, ethical models can be proposed as a guideline for all African leaders to lead their countries in peace. The conclusion I draw is that a normative framework of ethical models can be applied in conflict resolution in the African context. This framework draws on all four models, but leans toward deontology because of its strictness or rigour of universal rules or principles in any situation. , Thesis (MA) -- Faculty of Social Sciences and Humanities, 2008
- Full Text:
- Date Issued: 2008
- Authors: Mbangu, Muyingi
- Date: 2008
- Subjects: Africa -- Politics and government , Conflict management
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/25052 , vital:63948
- Description: Remarkably little research has been done about the potential of ethical models for violent conflict resolution in the African context. I will argue here that ethical models such as Utilitarianism, Deontologism, Virtue ethics, and African ethics can exert influence to help resolve conflict situations peacefully for the sake of African civilians generally and the DRC civilians in particular. This influence firstly becomes visible in the fact that ethical models can guide conflict resolution attempts to bring about conditions of peace, justice and freedom among African civilians in whichever nations state they find themselves. Secondly, ethical models can be established in the resolution of conflict for a lasting peace in the African context, and lastly, ethical models can be proposed as a guideline for all African leaders to lead their countries in peace. The conclusion I draw is that a normative framework of ethical models can be applied in conflict resolution in the African context. This framework draws on all four models, but leans toward deontology because of its strictness or rigour of universal rules or principles in any situation. , Thesis (MA) -- Faculty of Social Sciences and Humanities, 2008
- Full Text:
- Date Issued: 2008
A Comparison of Mitochondrial Heat Shock Protein 70 and Hsp70 Escort Protein 1 Orthologues from Trypanosoma brucei and Homo sapiens
- Authors: Hand, Francis Bryan
- Date: 2023-03-29
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/422281 , vital:71927
- Description: The causative agent of African trypanosomiasis, Trypanosoma brucei (T. brucei), has an expanded retinue of specialized heat shock proteins, which have been identified as crucial to the progression of the disease. These play a central role in disease progression and transmission through their involvement in cell-cycle pathways which bring about cell-cycle arrest and differentiation. Hsp70 proteins are essential for the maintenance of proteostasis in the cell. Mitochondrial Hsp70 (mtHsp70) is a highly conserved molecular chaperone required for both the translocation of nuclear encoded proteins across the two mitochondrial membranes and the subsequent folding of proteins in the matrix. The T. brucei genome encodes three copies of mtHsp70 which are 100% identical. MtHsp70 self-aggregates, a property unique to this isoform, and an Hsp70 escort protein (Hep1) is required to maintain the molecular chaperone in a soluble, functional state. This study aimed to compare the solubilizing interaction of Hep1 from T. brucei and Homo sapiens (H. sapien). The recently introduced Alphafold program was used to analyze the structures of mtHsp70 and Hep1 proteins and allowed observations of structures unavailable to other modelling techniques. The GVFEV motif found in the ATPase domain of mtHsp70s interacted with the linker region, resulting in aggregation, the Alphafold models produced indicated that the replacement of the lysine (K) residue within the KTFEV motif of DnaK (prokaryotic Hsp70) with Glycine (G), may abrogate bond formation between the motif and a region between lobe I and II of the ATPase domain. This may facilitate the aggregation reaction of mtHsp70 orthologues and provides a residue of interest for future studies. Both TbHep1 and HsHep1 reduced the thermal aggregation of TbmtHsp70 and mortalin (H. sapien mtHsp70) respectively, however, TbHep1 was ~ 15 % less effective than HsHep1 at higher concentrations (4 uM). TbHep1 itself appeared to be aggregation-prone when under conditions of thermal stress, Alphafold models suggest this may be due to an N-terminal α- helical structure not present in HsHep1. These results indicate that TbHep1 is functionally similar to HsHep1, however, the orthologue may operate in a unique manner which requires further investigation. , Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2023
- Full Text:
- Date Issued: 2023-03-29
- Authors: Hand, Francis Bryan
- Date: 2023-03-29
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/422281 , vital:71927
- Description: The causative agent of African trypanosomiasis, Trypanosoma brucei (T. brucei), has an expanded retinue of specialized heat shock proteins, which have been identified as crucial to the progression of the disease. These play a central role in disease progression and transmission through their involvement in cell-cycle pathways which bring about cell-cycle arrest and differentiation. Hsp70 proteins are essential for the maintenance of proteostasis in the cell. Mitochondrial Hsp70 (mtHsp70) is a highly conserved molecular chaperone required for both the translocation of nuclear encoded proteins across the two mitochondrial membranes and the subsequent folding of proteins in the matrix. The T. brucei genome encodes three copies of mtHsp70 which are 100% identical. MtHsp70 self-aggregates, a property unique to this isoform, and an Hsp70 escort protein (Hep1) is required to maintain the molecular chaperone in a soluble, functional state. This study aimed to compare the solubilizing interaction of Hep1 from T. brucei and Homo sapiens (H. sapien). The recently introduced Alphafold program was used to analyze the structures of mtHsp70 and Hep1 proteins and allowed observations of structures unavailable to other modelling techniques. The GVFEV motif found in the ATPase domain of mtHsp70s interacted with the linker region, resulting in aggregation, the Alphafold models produced indicated that the replacement of the lysine (K) residue within the KTFEV motif of DnaK (prokaryotic Hsp70) with Glycine (G), may abrogate bond formation between the motif and a region between lobe I and II of the ATPase domain. This may facilitate the aggregation reaction of mtHsp70 orthologues and provides a residue of interest for future studies. Both TbHep1 and HsHep1 reduced the thermal aggregation of TbmtHsp70 and mortalin (H. sapien mtHsp70) respectively, however, TbHep1 was ~ 15 % less effective than HsHep1 at higher concentrations (4 uM). TbHep1 itself appeared to be aggregation-prone when under conditions of thermal stress, Alphafold models suggest this may be due to an N-terminal α- helical structure not present in HsHep1. These results indicate that TbHep1 is functionally similar to HsHep1, however, the orthologue may operate in a unique manner which requires further investigation. , Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2023
- Full Text:
- Date Issued: 2023-03-29
A comparison of the self-esteem of black and white high school pupils
- Authors: Morrow, Brian Robert
- Date: 1988
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/193033 , vital:45292
- Description: This study investigated the level of self-esteem of black and white high-school students using the Rosenberg self-esteem scale. One hundred and eighty six subjects were used, 63 of them being white while 118 were black. A validation of the Rosenberg scale for the black sample was attempted using a correlation between the scale score and a rating of the subjects by teachers. The results of the study showed no significant difference between the self-esteem levels, while the validation study failed to confirm the validity of the test for black subjects in South Africa. However, the validation study v/as rejected as inconclusive and the results of the comparison accepted as confirmatory of previous research. An incidental positive finding revealed that white males have higher self-esteem than white females,. The theory and past research of self-esteem comparisons between racial groups is reviewed. The conclusion is reached in this study that the concept of self-esteem has outlasted its usefulness in the field of comparisons between racial groups and research of a qualitative nature .can provide further data for the understanding of differences between racial groups. , Thesis (MA) -- Faculty of Humanities, Psychology, 1988
- Full Text:
- Date Issued: 1988
- Authors: Morrow, Brian Robert
- Date: 1988
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/193033 , vital:45292
- Description: This study investigated the level of self-esteem of black and white high-school students using the Rosenberg self-esteem scale. One hundred and eighty six subjects were used, 63 of them being white while 118 were black. A validation of the Rosenberg scale for the black sample was attempted using a correlation between the scale score and a rating of the subjects by teachers. The results of the study showed no significant difference between the self-esteem levels, while the validation study failed to confirm the validity of the test for black subjects in South Africa. However, the validation study v/as rejected as inconclusive and the results of the comparison accepted as confirmatory of previous research. An incidental positive finding revealed that white males have higher self-esteem than white females,. The theory and past research of self-esteem comparisons between racial groups is reviewed. The conclusion is reached in this study that the concept of self-esteem has outlasted its usefulness in the field of comparisons between racial groups and research of a qualitative nature .can provide further data for the understanding of differences between racial groups. , Thesis (MA) -- Faculty of Humanities, Psychology, 1988
- Full Text:
- Date Issued: 1988
A compliance framework for IT governance adoption and use by state-owned entities in South Africa
- Authors: Nxozi, Monelo
- Date: 2023-03-31
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/419244 , vital:71628
- Description: Embargoed. Possible release date in early 2025. , Thesis (PhD) -- Faculty of Commerce, Information Systems, 2023
- Full Text:
- Date Issued: 2023-03-31
- Authors: Nxozi, Monelo
- Date: 2023-03-31
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/419244 , vital:71628
- Description: Embargoed. Possible release date in early 2025. , Thesis (PhD) -- Faculty of Commerce, Information Systems, 2023
- Full Text:
- Date Issued: 2023-03-31
A comprehensive approach to scalability assessment of ICTD projects : a case study of ICT4RED
- Authors: Baduza, Gugulethu Qhawekazi
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/178435 , vital:42939
- Description: Access restricted until April 2023. , Thesis (PhD) -- Faculty of Commerce, Information Systems, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Baduza, Gugulethu Qhawekazi
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/178435 , vital:42939
- Description: Access restricted until April 2023. , Thesis (PhD) -- Faculty of Commerce, Information Systems, 2021
- Full Text:
- Date Issued: 2021-04
A comprehensive review of the taxonomic diversity within the freshwater catfish genus Parauchenoglanis (Siluriformes, Auchenoglanididae)
- Authors: Sithole, Yonela
- Date: 2023-10-13
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/402992 , vital:69912
- Description: Thesis embargoed. To be released early 2026. , Thesis (PhD) -- Faculty of Science, Ichthyology & Fisheries Science, 2023
- Full Text:
- Date Issued: 2023-10-13
- Authors: Sithole, Yonela
- Date: 2023-10-13
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/402992 , vital:69912
- Description: Thesis embargoed. To be released early 2026. , Thesis (PhD) -- Faculty of Science, Ichthyology & Fisheries Science, 2023
- Full Text:
- Date Issued: 2023-10-13
A conceptual IT governance framework to guide the development of interoperable health information systems
- Authors: Matshaba, Lebogang
- Date: 2022-04-06
- Subjects: Information technology Management , Information technology Management Standards , Information technology Security measures , Medical informatics South Africa , Medical records Data processing , Internetworking (Telecommunication) , National health insurance South Africa , Design Science Research (DSR)
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/284570 , vital:56075
- Description: In light of changing health needs, health information systems are presented with a plethora of challenges. For instance, the rise of COVID-19 in the past year has led to the discourse on the strength of current health systems to support health needs and the readiness for the National Health Insurance in South Africa. In addition to operating in resource-constrained environments, the lack of synchrony between health information systems across health facilities led to the fragmentation of health information and diminished access to quality healthcare. This research, following the Design Science Research Methodology (DSRM) process, developed an IT governance conceptual framework (HISIG-CF), to inform the interoperability of health information systems. The HISIG-CF is developed from literature and qualitative data collected using an expert reviews method from practitioners in the healthcare sector who evaluated the constructs of the HISIG-CF. Thematic analysis and hermeneutics were used to analyse and interpret the data. The results revealed a need for more guidance to inform interoperability interventions and strengthen current health information systems. The contribution of this study is the HISIG-CF which is deemed relevant and potentially fit-for-purpose to improve health information systems interoperability within the healthcare sector in South Africa. , Thesis (MCom) -- Faculty of Commerce, Department of Information Systems, 2022
- Full Text:
- Date Issued: 2022-04-06
- Authors: Matshaba, Lebogang
- Date: 2022-04-06
- Subjects: Information technology Management , Information technology Management Standards , Information technology Security measures , Medical informatics South Africa , Medical records Data processing , Internetworking (Telecommunication) , National health insurance South Africa , Design Science Research (DSR)
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/284570 , vital:56075
- Description: In light of changing health needs, health information systems are presented with a plethora of challenges. For instance, the rise of COVID-19 in the past year has led to the discourse on the strength of current health systems to support health needs and the readiness for the National Health Insurance in South Africa. In addition to operating in resource-constrained environments, the lack of synchrony between health information systems across health facilities led to the fragmentation of health information and diminished access to quality healthcare. This research, following the Design Science Research Methodology (DSRM) process, developed an IT governance conceptual framework (HISIG-CF), to inform the interoperability of health information systems. The HISIG-CF is developed from literature and qualitative data collected using an expert reviews method from practitioners in the healthcare sector who evaluated the constructs of the HISIG-CF. Thematic analysis and hermeneutics were used to analyse and interpret the data. The results revealed a need for more guidance to inform interoperability interventions and strengthen current health information systems. The contribution of this study is the HISIG-CF which is deemed relevant and potentially fit-for-purpose to improve health information systems interoperability within the healthcare sector in South Africa. , Thesis (MCom) -- Faculty of Commerce, Department of Information Systems, 2022
- Full Text:
- Date Issued: 2022-04-06
A content analysis of fan perceptions of the South African soap opera 7de Laan
- Authors: Tsewu, Xola
- Date: 2021-05
- Subjects: Television soap operas , Television program genres
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/23226 , vital:56477
- Description: Soap operas are no longer only televised but the producers or content creators are branching out to other media, to make their content available to all kinds of audience. Increasingly, soap opera episodes can be shared not only on TV but also on the internet and this means its audience reach is extended. The focus of the study was on online audience of the South African soap opera 7de Laan, this exploratory study was conducted to assess the participation and activities of an online fan community. The study focused on a convenience sample of 10 asynchronous commentary forums attached to the 7de Laan YouTube channel. The sample included 1011 participants collectively providing 2312 comments. User names are not used in this study. The study intended to achieve the following objectives: 1. To conduct a qualitative content analysis of references to characters during the course of the ten episodes; 2. To find out what the users say about those characters and the plots in which they occur; and 3. To measure the coding in order to gain an impression of the interests and concerns of participants making up the online audience with respect to the soap opera narrative. The data set was coded and explored by means of the Qualitative data analysis programme NVivo 10. The raw material was collated into individual files for each participant, and imported into analysis programme. The analysis proceeded as three stages. The first stage revealed those characters that interested participants, ranging from those who attracted the most interest, to those who attracted the least. The second stage aimed to find out what themes coincided with these characters. The third stage aimed to find out what participants through about the soap opera 7de Laan itself. These stages correspond to three sets of appendices. The findings show a close correspondence between the relative airing of the five sub-plots that constitute the soap opera narrative, and the interest that online audience participants show through their comments. , Thesis (MSoc Sci) (Communication) --Faculty of Social Science and Humanities , 2021
- Full Text:
- Date Issued: 2021-05
- Authors: Tsewu, Xola
- Date: 2021-05
- Subjects: Television soap operas , Television program genres
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/23226 , vital:56477
- Description: Soap operas are no longer only televised but the producers or content creators are branching out to other media, to make their content available to all kinds of audience. Increasingly, soap opera episodes can be shared not only on TV but also on the internet and this means its audience reach is extended. The focus of the study was on online audience of the South African soap opera 7de Laan, this exploratory study was conducted to assess the participation and activities of an online fan community. The study focused on a convenience sample of 10 asynchronous commentary forums attached to the 7de Laan YouTube channel. The sample included 1011 participants collectively providing 2312 comments. User names are not used in this study. The study intended to achieve the following objectives: 1. To conduct a qualitative content analysis of references to characters during the course of the ten episodes; 2. To find out what the users say about those characters and the plots in which they occur; and 3. To measure the coding in order to gain an impression of the interests and concerns of participants making up the online audience with respect to the soap opera narrative. The data set was coded and explored by means of the Qualitative data analysis programme NVivo 10. The raw material was collated into individual files for each participant, and imported into analysis programme. The analysis proceeded as three stages. The first stage revealed those characters that interested participants, ranging from those who attracted the most interest, to those who attracted the least. The second stage aimed to find out what themes coincided with these characters. The third stage aimed to find out what participants through about the soap opera 7de Laan itself. These stages correspond to three sets of appendices. The findings show a close correspondence between the relative airing of the five sub-plots that constitute the soap opera narrative, and the interest that online audience participants show through their comments. , Thesis (MSoc Sci) (Communication) --Faculty of Social Science and Humanities , 2021
- Full Text:
- Date Issued: 2021-05