Grasses as suitable targets for classical weed biological control
- Sutton, Guy F, Day, Michael D, den Breeyen, Alana, Goolsby, J A, Cristofaro, M, McConnachie, Andrew J, Paterson, Iain D
- Authors: Sutton, Guy F , Day, Michael D , den Breeyen, Alana , Goolsby, J A , Cristofaro, M , McConnachie, Andrew J , Paterson, Iain D
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/417984 , vital:71499 , xlink:href="https://doi.org/10.1007/s10526-019-09968-8"
- Description: Grasses are amongst the most abundant and environmentally damaging invasive weeds worldwide. Biological control is frequently employed as a sustainable and cost-effective management strategy for many weeds. However, grasses have not been actively pursued as targets for classical weed biological control due to a perceived lack of sufficiently specialised and damaging natural enemies to use as biological control agents. There are also concerns that the risk posed to economically important crop/pasture species and closely-related native species is too great to consider implementing biological control for invasive grasses. In this paper, we review the literature and demonstrate that grasses can possess suitably host-specific and damaging natural enemies to warrant consideration as potential biological control agents. The risk of grass biological control is no greater than for other weedy taxa if practitioners follow appropriately rigorous risk assessments protocols.
- Full Text:
- Date Issued: 2019
- Authors: Sutton, Guy F , Day, Michael D , den Breeyen, Alana , Goolsby, J A , Cristofaro, M , McConnachie, Andrew J , Paterson, Iain D
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/417984 , vital:71499 , xlink:href="https://doi.org/10.1007/s10526-019-09968-8"
- Description: Grasses are amongst the most abundant and environmentally damaging invasive weeds worldwide. Biological control is frequently employed as a sustainable and cost-effective management strategy for many weeds. However, grasses have not been actively pursued as targets for classical weed biological control due to a perceived lack of sufficiently specialised and damaging natural enemies to use as biological control agents. There are also concerns that the risk posed to economically important crop/pasture species and closely-related native species is too great to consider implementing biological control for invasive grasses. In this paper, we review the literature and demonstrate that grasses can possess suitably host-specific and damaging natural enemies to warrant consideration as potential biological control agents. The risk of grass biological control is no greater than for other weedy taxa if practitioners follow appropriately rigorous risk assessments protocols.
- Full Text:
- Date Issued: 2019
Green entrepreneurship model utilising the system dynamics approach: A review
- Diale, Dineo, Kanakana-Katumba, Mukondeleli G, Maladzhi, Rendani W
- Authors: Diale, Dineo , Kanakana-Katumba, Mukondeleli G , Maladzhi, Rendani W
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/450677 , vital:74973 , xlink:href="https://ieeexplore.ieee.org/abstract/document/8978804"
- Description: Green entrepreneurship as a concept is still in its infancy stages around the globe. In order to assess the Green entrepreneurship ecosystem, the researchers adopted a systems dynamic approach to determine key variables that will enable the development of the system. A theoretical review was conducted through a literature review of which n=44 sources met the criteria that the researchers set for ecosystem or variables. Through review of data, the researchers discovered that ecosystem of green entrepreneurship needs to be viewed from meso, macro and micro level with key variables such as green entrepreneurial motives, start-up factors, green support mechanisms, performance and monitoring tools as well as barriers to environmental entrepreneurship. A virtual abstract simulation of system dynamics approach from the systematic review is also formulated in the current paper. Brief summary of findings are classified and explained. Recommendations for future research are also made towards the end of the research paper.
- Full Text:
- Date Issued: 2019
- Authors: Diale, Dineo , Kanakana-Katumba, Mukondeleli G , Maladzhi, Rendani W
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/450677 , vital:74973 , xlink:href="https://ieeexplore.ieee.org/abstract/document/8978804"
- Description: Green entrepreneurship as a concept is still in its infancy stages around the globe. In order to assess the Green entrepreneurship ecosystem, the researchers adopted a systems dynamic approach to determine key variables that will enable the development of the system. A theoretical review was conducted through a literature review of which n=44 sources met the criteria that the researchers set for ecosystem or variables. Through review of data, the researchers discovered that ecosystem of green entrepreneurship needs to be viewed from meso, macro and micro level with key variables such as green entrepreneurial motives, start-up factors, green support mechanisms, performance and monitoring tools as well as barriers to environmental entrepreneurship. A virtual abstract simulation of system dynamics approach from the systematic review is also formulated in the current paper. Brief summary of findings are classified and explained. Recommendations for future research are also made towards the end of the research paper.
- Full Text:
- Date Issued: 2019
Green skills for agriculture A method for focusing demand analysis and prioritisation
- Authors: Rosenberg, Eureta
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , book chapter
- Identifier: http://hdl.handle.net/10962/436026 , vital:73221 , ISBN 9780429279362 , https://www.taylorfrancis.com/chapters/edit/10.4324/9780429279362-13/synthesis-elaboration-critical-realist-methodology-green-skills-research-eureta-rosenberg
- Description: This chapter is the second of the occupational demand studies that share insights about a methodology for determining green skills demand with a laminated approach and value chain anal-ysis. Based on research into skills for Climate Smart Agriculture (Cobban and Visser, 2017), it provides insight into the history and features of agriculture in South Africa that shape current skills needs. Drawing on one component of Cobban and Visser’s study, and employing a critical revision of the ‘climate smart’ framing, it shares findings about what green skills are needed for more sustainable poultry farming in which occupations to contextualise the discussion on methodology. This chapter contrasts the layered, in-depth green skills studies with approaches aiming for broader coverage and representivity, and illustrates the use of multi-criterion ‘hotspotting’ to prioritise among skills needs at strategic leverage points for social-ecological trans-formation. The case of the agricultural study illustrates the val-ue of smaller scale, in-depth studies that provide the occupa-tion level insights to inform skills planning and investment that is needed if agriculture is to sustain itself and all those it could – and should – benefit.
- Full Text:
- Date Issued: 2019
- Authors: Rosenberg, Eureta
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , book chapter
- Identifier: http://hdl.handle.net/10962/436026 , vital:73221 , ISBN 9780429279362 , https://www.taylorfrancis.com/chapters/edit/10.4324/9780429279362-13/synthesis-elaboration-critical-realist-methodology-green-skills-research-eureta-rosenberg
- Description: This chapter is the second of the occupational demand studies that share insights about a methodology for determining green skills demand with a laminated approach and value chain anal-ysis. Based on research into skills for Climate Smart Agriculture (Cobban and Visser, 2017), it provides insight into the history and features of agriculture in South Africa that shape current skills needs. Drawing on one component of Cobban and Visser’s study, and employing a critical revision of the ‘climate smart’ framing, it shares findings about what green skills are needed for more sustainable poultry farming in which occupations to contextualise the discussion on methodology. This chapter contrasts the layered, in-depth green skills studies with approaches aiming for broader coverage and representivity, and illustrates the use of multi-criterion ‘hotspotting’ to prioritise among skills needs at strategic leverage points for social-ecological trans-formation. The case of the agricultural study illustrates the val-ue of smaller scale, in-depth studies that provide the occupa-tion level insights to inform skills planning and investment that is needed if agriculture is to sustain itself and all those it could – and should – benefit.
- Full Text:
- Date Issued: 2019
Green skills research in South Africa
- Rosenberg, Eureta, Ramsarup, Preesha, Lotz-Sisitka, Heila
- Authors: Rosenberg, Eureta , Ramsarup, Preesha , Lotz-Sisitka, Heila
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , book chapter
- Identifier: http://hdl.handle.net/10962/436040 , vital:73222 , ISBN 9780429279362 , https://www.taylorfrancis.com/chapters/edit/10.4324/9780429279362-13/synthesis-elaboration-critical-realist-methodology-green-skills-research-eureta-rosenberg
- Description: This book brings the diverse contributions offered in the different sections of this book together into a pathway for new policy development research, new forms of critical skills research and ongoing engagement with education and training system development. The chapter first provides a meta-reflection on the different types of green skills research that are needed to, in combination, make a stronger impact on the national system of skills research and planning. Secondly, the chapter makes a strong argument for aligning green skills research to the Sustainable Development Goals, and their critical and contextual articulation at national level, with emphasis on working with the cross-cutting Sustainable Development Goal (SDG) 4, Target 4.7 that motivates for governments to include a focus on education and sustainable development across the lifelong learning system in order to enable and support learning and skills for enabling the other SDGs to be realised in practice. Lastly, the chapter considers the shift in the way that work is considered when political economy meets political ecology, and we argue that work transforms towards not only a productive focus, or a social focus, but also an ontologically grounded regenerative focus, much needed at the start of the twenty-first century.
- Full Text:
- Date Issued: 2019
- Authors: Rosenberg, Eureta , Ramsarup, Preesha , Lotz-Sisitka, Heila
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , book chapter
- Identifier: http://hdl.handle.net/10962/436040 , vital:73222 , ISBN 9780429279362 , https://www.taylorfrancis.com/chapters/edit/10.4324/9780429279362-13/synthesis-elaboration-critical-realist-methodology-green-skills-research-eureta-rosenberg
- Description: This book brings the diverse contributions offered in the different sections of this book together into a pathway for new policy development research, new forms of critical skills research and ongoing engagement with education and training system development. The chapter first provides a meta-reflection on the different types of green skills research that are needed to, in combination, make a stronger impact on the national system of skills research and planning. Secondly, the chapter makes a strong argument for aligning green skills research to the Sustainable Development Goals, and their critical and contextual articulation at national level, with emphasis on working with the cross-cutting Sustainable Development Goal (SDG) 4, Target 4.7 that motivates for governments to include a focus on education and sustainable development across the lifelong learning system in order to enable and support learning and skills for enabling the other SDGs to be realised in practice. Lastly, the chapter considers the shift in the way that work is considered when political economy meets political ecology, and we argue that work transforms towards not only a productive focus, or a social focus, but also an ontologically grounded regenerative focus, much needed at the start of the twenty-first century.
- Full Text:
- Date Issued: 2019
Green skills research: Implications for systems, policy, work and learning
- Lotz-Sisitka, Heila, Ramsarup, Presha
- Authors: Lotz-Sisitka, Heila , Ramsarup, Presha
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/392875 , vital:68808 , ISBN 9780429279362 , https://doi.org/10.4324/9780429279362
- Description: This chapter brings the diverse contributions offered in the different sections of this book together into a pathway for new policy development research, new forms of critical skills research and ongoing engagement with education and training system development. The chapter first provides a meta-reflection on the different types of green skills research that are needed to, in combination, make a stronger impact on the national system of skills research and planning. Secondly, the chapter makes a strong argument for aligning green skills research to the Sustainable Development Goals, and their critical and contextual articulation at national level, with emphasis on working with the cross-cutting Sustainable Development Goal (SDG) 4, Target 4.7 that motivates for governments to include a focus on education and sustainable development across the lifelong learning system in order to enable and support learning and skills for enabling the other SDGs to be realised in practice. Lastly, the chapter considers the shift in the way that work is considered when political economy meets political ecology, and we argue that work transforms towards not only a productive focus, or a social focus, but also an ontologically grounded regenerative focus, much needed at the start of the twenty-first century.
- Full Text:
- Date Issued: 2019
- Authors: Lotz-Sisitka, Heila , Ramsarup, Presha
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/392875 , vital:68808 , ISBN 9780429279362 , https://doi.org/10.4324/9780429279362
- Description: This chapter brings the diverse contributions offered in the different sections of this book together into a pathway for new policy development research, new forms of critical skills research and ongoing engagement with education and training system development. The chapter first provides a meta-reflection on the different types of green skills research that are needed to, in combination, make a stronger impact on the national system of skills research and planning. Secondly, the chapter makes a strong argument for aligning green skills research to the Sustainable Development Goals, and their critical and contextual articulation at national level, with emphasis on working with the cross-cutting Sustainable Development Goal (SDG) 4, Target 4.7 that motivates for governments to include a focus on education and sustainable development across the lifelong learning system in order to enable and support learning and skills for enabling the other SDGs to be realised in practice. Lastly, the chapter considers the shift in the way that work is considered when political economy meets political ecology, and we argue that work transforms towards not only a productive focus, or a social focus, but also an ontologically grounded regenerative focus, much needed at the start of the twenty-first century.
- Full Text:
- Date Issued: 2019
Green skills supply: Research from providers’ vantage point (s)
- Authors: Lotz-Sisitka, Heila
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , book chapter
- Identifier: http://hdl.handle.net/10962/436051 , vital:73223 , ISBN 9780429279362 , https://www.taylorfrancis.com/chapters/edit/10.4324/9780429279362-13/synthesis-elaboration-critical-realist-methodology-green-skills-research-eureta-rosenberg
- Description: This chapter emerges from a need to consider the dynamics of supply side research for green skills from a providers’ vantage point. The chapter starts with the argument that environment and sustainability skills are cross institutional, cross sectoral and also inter- and transdisciplinary. The chapter notes that there are a wide variety and diversity of supply side studies that can offer perspective on the many dynamics of green skills supply and provisioning. Four cases have been selected and brought into view to illuminate the influence of context and history on designing curricula and the importance of reflexive curriculum review studies, whole institution approaches and transformative, transgressive forms of learning that move beyond the boundaries of single institutions. These studies are also brought into view to indicate the scope and depth of contextual, systemic and engaged research that is required to develop transformative orientations and perspectives on green skills supply, taking skills system supply beyond the traditional training needs analysis. The chapter argues that this is an important dimension of green skills research, if conceptualised within just transitions and transformations to sustainability.
- Full Text:
- Date Issued: 2019
- Authors: Lotz-Sisitka, Heila
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , book chapter
- Identifier: http://hdl.handle.net/10962/436051 , vital:73223 , ISBN 9780429279362 , https://www.taylorfrancis.com/chapters/edit/10.4324/9780429279362-13/synthesis-elaboration-critical-realist-methodology-green-skills-research-eureta-rosenberg
- Description: This chapter emerges from a need to consider the dynamics of supply side research for green skills from a providers’ vantage point. The chapter starts with the argument that environment and sustainability skills are cross institutional, cross sectoral and also inter- and transdisciplinary. The chapter notes that there are a wide variety and diversity of supply side studies that can offer perspective on the many dynamics of green skills supply and provisioning. Four cases have been selected and brought into view to illuminate the influence of context and history on designing curricula and the importance of reflexive curriculum review studies, whole institution approaches and transformative, transgressive forms of learning that move beyond the boundaries of single institutions. These studies are also brought into view to indicate the scope and depth of contextual, systemic and engaged research that is required to develop transformative orientations and perspectives on green skills supply, taking skills system supply beyond the traditional training needs analysis. The chapter argues that this is an important dimension of green skills research, if conceptualised within just transitions and transformations to sustainability.
- Full Text:
- Date Issued: 2019
Green skills supply: Research from providers’ vantage point(s)
- Authors: Lotz-Sisitka, Heila
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/392895 , vital:68810 , ISBN 9780429279362 , https://doi.org/10.4324/9780429279362
- Description: This chapter emerges from a need to consider the dynamics of supply side research for green skills from a providers’ vantage point. The chapter starts with the argument that environment and sustainability skills are cross institutional, cross sectoral and also inter- and transdisciplinary. The chapter notes that there are a wide variety and diversity of supply side studies that can offer perspective on the many dynamics of green skills supply and provisioning. Four cases have been selected and brought into view to illuminate the influence of context and history on designing curricula and the importance of reflexive curriculum review studies, whole institution approaches and transformative, transgressive forms of learning that move beyond the boundaries of single institutions. These studies are also brought into view to indicate the scope and depth of contextual, systemic and engaged research that is required to develop transformative orientations and perspectives on green skills supply, taking skills system supply beyond the traditional training needs analysis. The chapter argues that this is an important dimension of green skills research, if conceptualised within just transitions and transformations to sustainability.
- Full Text:
- Date Issued: 2019
- Authors: Lotz-Sisitka, Heila
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/392895 , vital:68810 , ISBN 9780429279362 , https://doi.org/10.4324/9780429279362
- Description: This chapter emerges from a need to consider the dynamics of supply side research for green skills from a providers’ vantage point. The chapter starts with the argument that environment and sustainability skills are cross institutional, cross sectoral and also inter- and transdisciplinary. The chapter notes that there are a wide variety and diversity of supply side studies that can offer perspective on the many dynamics of green skills supply and provisioning. Four cases have been selected and brought into view to illuminate the influence of context and history on designing curricula and the importance of reflexive curriculum review studies, whole institution approaches and transformative, transgressive forms of learning that move beyond the boundaries of single institutions. These studies are also brought into view to indicate the scope and depth of contextual, systemic and engaged research that is required to develop transformative orientations and perspectives on green skills supply, taking skills system supply beyond the traditional training needs analysis. The chapter argues that this is an important dimension of green skills research, if conceptualised within just transitions and transformations to sustainability.
- Full Text:
- Date Issued: 2019
Green synthesis of zinc oxide nanoparticles using Solanum torvum (L) leaf extract and evaluation of the toxicological profile of the ZnO nanoparticles–hydrogel composite in Wistar albino rats
- Ezealisiji, Kenneth E, Siwe-Noundou, Xavier, Maduelosi, Blessing, Nwachukwu, Nkemakolam, Krause, Rui W M
- Authors: Ezealisiji, Kenneth E , Siwe-Noundou, Xavier , Maduelosi, Blessing , Nwachukwu, Nkemakolam , Krause, Rui W M
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/194015 , vital:45416 , xlink:href="https://doi.org/10.1007/s40089-018-0263-1"
- Description: Current study reports a simple and one-pot synthesis of zinc oxide nanoparticles (ZnONPs) using an aqueous extract of Solanum torvum and evaluation of its toxicological profile (0.5% w/w and 1.0% w/w) in Wistar albino rats with respect to the biochemical index. The nanoparticles were characterized using ultraviolet–visible spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction technique. Dynamic light scattering (DLS) and zeta potential of synthesized nanoparticles were analyzed to know the average size and stability of particles. Synthesized nanoparticles were stable, discreet, and mostly spherical, and size of particles was within the nanometre range. Biochemical markers of hepatic and renal functions were measured. Zinc oxide nanoparticles significantly decreased serum uric acid level (p less than 0.001) in a dose-dependent manner, while the serum alkaline phosphatase level was increased at the two test doses. The level of alanine transaminase was increased after exposure for 28 days (p less than 0.05). This study concludes that biogenic zinc oxide nanoparticles-infused hydrogel applied dermatologically could affect hepatic and renal performance in rats, and there was an observed cumulative toxicological effect with time of exposure.
- Full Text:
- Date Issued: 2019
- Authors: Ezealisiji, Kenneth E , Siwe-Noundou, Xavier , Maduelosi, Blessing , Nwachukwu, Nkemakolam , Krause, Rui W M
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/194015 , vital:45416 , xlink:href="https://doi.org/10.1007/s40089-018-0263-1"
- Description: Current study reports a simple and one-pot synthesis of zinc oxide nanoparticles (ZnONPs) using an aqueous extract of Solanum torvum and evaluation of its toxicological profile (0.5% w/w and 1.0% w/w) in Wistar albino rats with respect to the biochemical index. The nanoparticles were characterized using ultraviolet–visible spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction technique. Dynamic light scattering (DLS) and zeta potential of synthesized nanoparticles were analyzed to know the average size and stability of particles. Synthesized nanoparticles were stable, discreet, and mostly spherical, and size of particles was within the nanometre range. Biochemical markers of hepatic and renal functions were measured. Zinc oxide nanoparticles significantly decreased serum uric acid level (p less than 0.001) in a dose-dependent manner, while the serum alkaline phosphatase level was increased at the two test doses. The level of alanine transaminase was increased after exposure for 28 days (p less than 0.05). This study concludes that biogenic zinc oxide nanoparticles-infused hydrogel applied dermatologically could affect hepatic and renal performance in rats, and there was an observed cumulative toxicological effect with time of exposure.
- Full Text:
- Date Issued: 2019
High throughput screening, docking, and molecular dynamics studies to identify potential inhibitors of human calcium/calmodulin-dependent protein kinase IV
- Beg, Anam, Khan, Faez I, Lobb, Kevin A, Islam, Asimul, Ahmad, Faizan, Hassan, M Imtaiyaz
- Authors: Beg, Anam , Khan, Faez I , Lobb, Kevin A , Islam, Asimul , Ahmad, Faizan , Hassan, M Imtaiyaz
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/${Handle} , vital:74587 , xlink:href="https://doi.org/10.1080/07391102.2018.1479310"
- Description: Calcium/calmodulin-dependent protein kinase IV (CAMKIV) is associated with many diseases including cancer and neurodegenerative disorders and thus being considered as a potential drug target. Here, we have employed the knowledge of three-dimensional structure of CAMKIV to identify new inhibitors for possible therapeutic intervention. We have employed virtual high throughput screening of 12,500 natural compounds of Zinc database to screen the best possible inhibitors of CAMKIV. Subsequently, 40 compounds which showed significant docking scores (−11.6 to −10.0 kcal/mol) were selected and further filtered through Lipinski rule and drug likeness parameter to get best inhibitors of CAMKIV. Docking results are indicating that ligands are binding to the hydrophobic cavity of the kinase domain of CAMKIV and forming a significant number of non-covalent interactions. Four compounds, ZINC02098378, ZINC12866674, ZINC04293413, and ZINC13403020, showing excellent binding affinity and drug likeness were subjected to molecular dynamics simulation to evaluate their mechanism of interaction and stability of protein-ligand complex. Our observations clearly suggesting that these selected ligands may be further employed for therapeutic intervention to address CAMKIV associated diseases.
- Full Text:
- Date Issued: 2019
- Authors: Beg, Anam , Khan, Faez I , Lobb, Kevin A , Islam, Asimul , Ahmad, Faizan , Hassan, M Imtaiyaz
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/${Handle} , vital:74587 , xlink:href="https://doi.org/10.1080/07391102.2018.1479310"
- Description: Calcium/calmodulin-dependent protein kinase IV (CAMKIV) is associated with many diseases including cancer and neurodegenerative disorders and thus being considered as a potential drug target. Here, we have employed the knowledge of three-dimensional structure of CAMKIV to identify new inhibitors for possible therapeutic intervention. We have employed virtual high throughput screening of 12,500 natural compounds of Zinc database to screen the best possible inhibitors of CAMKIV. Subsequently, 40 compounds which showed significant docking scores (−11.6 to −10.0 kcal/mol) were selected and further filtered through Lipinski rule and drug likeness parameter to get best inhibitors of CAMKIV. Docking results are indicating that ligands are binding to the hydrophobic cavity of the kinase domain of CAMKIV and forming a significant number of non-covalent interactions. Four compounds, ZINC02098378, ZINC12866674, ZINC04293413, and ZINC13403020, showing excellent binding affinity and drug likeness were subjected to molecular dynamics simulation to evaluate their mechanism of interaction and stability of protein-ligand complex. Our observations clearly suggesting that these selected ligands may be further employed for therapeutic intervention to address CAMKIV associated diseases.
- Full Text:
- Date Issued: 2019
How to engage with challenges facing Water and Sanitation Services (WSS) in small municipalities
- Clifford-Holmes, Jai K, Carnohan, Shane, Slinger, Jill W, Palmer, Carolyn G
- Authors: Clifford-Holmes, Jai K , Carnohan, Shane , Slinger, Jill W , Palmer, Carolyn G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437869 , vital:73418 , ISBN 978-1 4312-0988-0 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 120-18 web.pdf
- Description: Smaller South African municipalities have many urgent calls on their resources AT THE SAME TIME. • The need to pay salaries is sometimes more important than other concerns. • It is not always clear how different problems affect each other. • It is difficult to decide what to do each day. • There are always urgent crises to attend to. • There are many meetings to attend. • Operational and political priorities can be different. Thinking of, and talking about your municipality as a SYSTEM will help you to ACT in ways that reduce the impact of these issues. This handbook relates specifically to water and sanitation issues.
- Full Text:
- Date Issued: 2019
- Authors: Clifford-Holmes, Jai K , Carnohan, Shane , Slinger, Jill W , Palmer, Carolyn G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437869 , vital:73418 , ISBN 978-1 4312-0988-0 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 120-18 web.pdf
- Description: Smaller South African municipalities have many urgent calls on their resources AT THE SAME TIME. • The need to pay salaries is sometimes more important than other concerns. • It is not always clear how different problems affect each other. • It is difficult to decide what to do each day. • There are always urgent crises to attend to. • There are many meetings to attend. • Operational and political priorities can be different. Thinking of, and talking about your municipality as a SYSTEM will help you to ACT in ways that reduce the impact of these issues. This handbook relates specifically to water and sanitation issues.
- Full Text:
- Date Issued: 2019
How to engage with coal mines through Catchment Management Forums
- Munnik, Victor, Holleman, Helen, Wolff, Margaret G, Palmer, Carolyn G
- Authors: Munnik, Victor , Holleman, Helen , Wolff, Margaret G , Palmer, Carolyn G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437882 , vital:73419 , ISBN 978-1 4312-0990-3 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 122-18 web.pdf
- Description: This book was written for the catchment management forum (CMF) in the Upper Komati Forum (UKF), and they share their experience in order to help other CMFs understand the damage coal mining does to our water resources. This booklet should be used with How to think and act in ways that make Adaptive IWRM practically possible and How to establish and run a Catchment Management Forum.
- Full Text:
- Date Issued: 2019
- Authors: Munnik, Victor , Holleman, Helen , Wolff, Margaret G , Palmer, Carolyn G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437882 , vital:73419 , ISBN 978-1 4312-0990-3 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 122-18 web.pdf
- Description: This book was written for the catchment management forum (CMF) in the Upper Komati Forum (UKF), and they share their experience in order to help other CMFs understand the damage coal mining does to our water resources. This booklet should be used with How to think and act in ways that make Adaptive IWRM practically possible and How to establish and run a Catchment Management Forum.
- Full Text:
- Date Issued: 2019
How to manage water quantity and water quality together
- Retief, Hugo, Holleman, Helen, Palmer, Carolyn G
- Authors: Retief, Hugo , Holleman, Helen , Palmer, Carolyn G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437907 , vital:73421 , ISBN 978-1 4312-0987-3 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP%20119-18%20web.pdf
- Description: All over the world water resources are under pressure due to over-use and pollution, and finding ways to meet the need for water is becoming increasingly difficult. Nat-ural variation in rainfall also contributes to making planning and management of flow and water quality, and especially these together, complex and difficult. People have realised that it is important to consider many factors when managing water – they call this Integrated Water Resource Management (IWRM). Integrating many factors is in line with the ideas that all the “How to” handbooks are based on. Please do read the foundation handbook: “How to think and act in ways that make Adap-tive IWRM practically possible”. In this handbook we consider how to integrate flow and water quality. Although some writers think taking account of all the many fac-tors is too difficult, others – including the authors of this handbook – believe it is essential to try if we want to find the balance between use and protection. IWRM also recognises that it is vital to involve stakeholders in decision-making if protec-tion of our water resources is going to be successful.
- Full Text:
- Date Issued: 2019
- Authors: Retief, Hugo , Holleman, Helen , Palmer, Carolyn G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437907 , vital:73421 , ISBN 978-1 4312-0987-3 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP%20119-18%20web.pdf
- Description: All over the world water resources are under pressure due to over-use and pollution, and finding ways to meet the need for water is becoming increasingly difficult. Nat-ural variation in rainfall also contributes to making planning and management of flow and water quality, and especially these together, complex and difficult. People have realised that it is important to consider many factors when managing water – they call this Integrated Water Resource Management (IWRM). Integrating many factors is in line with the ideas that all the “How to” handbooks are based on. Please do read the foundation handbook: “How to think and act in ways that make Adap-tive IWRM practically possible”. In this handbook we consider how to integrate flow and water quality. Although some writers think taking account of all the many fac-tors is too difficult, others – including the authors of this handbook – believe it is essential to try if we want to find the balance between use and protection. IWRM also recognises that it is vital to involve stakeholders in decision-making if protec-tion of our water resources is going to be successful.
- Full Text:
- Date Issued: 2019
How to think and act in ways that make Adaptive IWRM practically possible
- Palmer, Carolyn G, Biggs, Harry, Rogers, Kevin H, du Toit, Derick, Pollard, Sharon
- Authors: Palmer, Carolyn G , Biggs, Harry , Rogers, Kevin H , du Toit, Derick , Pollard, Sharon
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437937 , vital:73423 , ISBN 978-1 4312-0984-2 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 116-18 web.pdf
- Description: “We cross the river by feeling the stones with our feet” (Chinese proverb). Most of the ideas in this handbook you already know from living your life. Here we put your everyday experience and knowledge into the language of managing water. In the last twenty years, there has been a lot of talk about new ways to make Integrated Water Resource Management or “IWRM” work, but not nearly as much useful knowledge about how to put those ideas into practice. We now know how to use a set of ideas and ways of understanding that help us to make IWRM really work prac-tically. We call this practical way of working: Adaptive IWRM. This is the first in a series of handbooks to come out of a WRC project Practising Adaptive IWRM (Inte-grated Water Resource Management (IWRM) in South Africa: towards practising a new paradigm* [TPNP]). The TPNP project researchers have had experience with many different situations in southern Africa, where people have grappled* with put-ting the ideas of complexity* and integration into practice.
- Full Text:
- Date Issued: 2019
- Authors: Palmer, Carolyn G , Biggs, Harry , Rogers, Kevin H , du Toit, Derick , Pollard, Sharon
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437937 , vital:73423 , ISBN 978-1 4312-0984-2 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 116-18 web.pdf
- Description: “We cross the river by feeling the stones with our feet” (Chinese proverb). Most of the ideas in this handbook you already know from living your life. Here we put your everyday experience and knowledge into the language of managing water. In the last twenty years, there has been a lot of talk about new ways to make Integrated Water Resource Management or “IWRM” work, but not nearly as much useful knowledge about how to put those ideas into practice. We now know how to use a set of ideas and ways of understanding that help us to make IWRM really work prac-tically. We call this practical way of working: Adaptive IWRM. This is the first in a series of handbooks to come out of a WRC project Practising Adaptive IWRM (Inte-grated Water Resource Management (IWRM) in South Africa: towards practising a new paradigm* [TPNP]). The TPNP project researchers have had experience with many different situations in southern Africa, where people have grappled* with put-ting the ideas of complexity* and integration into practice.
- Full Text:
- Date Issued: 2019
How to use Strategic Adaptive Management (SAM) and the Adaptive Planning Process (APP) to build a shared catchment future
- Palmer, Carolyn G, Rogers, Kevin H, Holleman, Helen, Wolff, Margaret G
- Authors: Palmer, Carolyn G , Rogers, Kevin H , Holleman, Helen , Wolff, Margaret G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437965 , vital:73425 , ISBN 978-1 4312-0991-0 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 123-18 web.pdf
- Description: For members of Catchment Management Forums (CMFs) and Catchment Manage-ment Agencies (CMAs). CMFs are made up of people who represent all the stake-holders in a catchment. They are the people who know the catchment best, and therefore are in the best position to alert CMAs to local issues and to help develop the strategic plans for their local catchment. However, catchments are dynamic*, complex* systems that need a special planning approach – and that is what this handbook is about. If one part of a catchment is neglected and damaged, it affects the whole system and everyone living in it. We use and recommend a flexible, adap-tive approach in which everyone involved in the planning is both a teacher and a learner, and where everyone contributes their special wisdom to developing a sustainable plan for the catchment.
- Full Text:
- Date Issued: 2019
- Authors: Palmer, Carolyn G , Rogers, Kevin H , Holleman, Helen , Wolff, Margaret G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437965 , vital:73425 , ISBN 978-1 4312-0991-0 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 123-18 web.pdf
- Description: For members of Catchment Management Forums (CMFs) and Catchment Manage-ment Agencies (CMAs). CMFs are made up of people who represent all the stake-holders in a catchment. They are the people who know the catchment best, and therefore are in the best position to alert CMAs to local issues and to help develop the strategic plans for their local catchment. However, catchments are dynamic*, complex* systems that need a special planning approach – and that is what this handbook is about. If one part of a catchment is neglected and damaged, it affects the whole system and everyone living in it. We use and recommend a flexible, adap-tive approach in which everyone involved in the planning is both a teacher and a learner, and where everyone contributes their special wisdom to developing a sustainable plan for the catchment.
- Full Text:
- Date Issued: 2019
Identification and evaluation of bioactive natural products as potential inhibitors of human microtubule affinity-regulating kinase 4 (MARK4)
- Mohammad, Taj, Khan, Faez I, Lobb, Kevin A, Islam, Asimul, Ahmad, Faizan, Hassan, M Imtaiyaz
- Authors: Mohammad, Taj , Khan, Faez I , Lobb, Kevin A , Islam, Asimul , Ahmad, Faizan , Hassan, M Imtaiyaz
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/447159 , vital:74588 , xlink:href="https://doi.org/10.1080/07391102.2018.1468282"
- Description: Microtubule affinity-regulating kinase 4 (MARK4) has recently been identified as a potential drug target for several complex diseases including cancer, diabetes and neurodegenerative disorders. Inhibition of MARK4 activity is an appealing therapeutic option to treat such diseases. Here, we have performed structure-based virtual high-throughput screening of 100,000 naturally occurring compounds from ZINC database against MARK4 to find its potential inhibitors. The resulted hits were selected, based on the binding affinities, docking scores and selectivity. Further, binding energy calculation, Lipinski filtration and ADMET prediction were carried out to find safe and better hits against MARK4. Best 10 compounds bearing high specificity and binding efficiency were selected, and their binding pattern to MARK4 was analyzed in detail. Finally, 100 ns molecular dynamics simulation was performed to evaluate; the dynamics stability of MARK4-compound complex. In conclusion, these selected natural compounds from ZINC database might be potential leads against MARK4, and can further be exploited in drug design and development for associated diseases.
- Full Text:
- Date Issued: 2019
- Authors: Mohammad, Taj , Khan, Faez I , Lobb, Kevin A , Islam, Asimul , Ahmad, Faizan , Hassan, M Imtaiyaz
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/447159 , vital:74588 , xlink:href="https://doi.org/10.1080/07391102.2018.1468282"
- Description: Microtubule affinity-regulating kinase 4 (MARK4) has recently been identified as a potential drug target for several complex diseases including cancer, diabetes and neurodegenerative disorders. Inhibition of MARK4 activity is an appealing therapeutic option to treat such diseases. Here, we have performed structure-based virtual high-throughput screening of 100,000 naturally occurring compounds from ZINC database against MARK4 to find its potential inhibitors. The resulted hits were selected, based on the binding affinities, docking scores and selectivity. Further, binding energy calculation, Lipinski filtration and ADMET prediction were carried out to find safe and better hits against MARK4. Best 10 compounds bearing high specificity and binding efficiency were selected, and their binding pattern to MARK4 was analyzed in detail. Finally, 100 ns molecular dynamics simulation was performed to evaluate; the dynamics stability of MARK4-compound complex. In conclusion, these selected natural compounds from ZINC database might be potential leads against MARK4, and can further be exploited in drug design and development for associated diseases.
- Full Text:
- Date Issued: 2019
In vitro antimalarial, antitrypanosomal and HIV-1 integrase inhibitory activities of two Cameroonian medicinal plants
- Fouokeng, Yannick, Feumo Feusso, H M, Mbosso Teinkela, Jean E, Siwe-Noundou, Xavier, Wintjens, René T, Isaacs, Michelle, Hoppe, Heinrich C, Krause, Rui W M, Azébazé, Anatole G B, Vardamides, Juliette C
- Authors: Fouokeng, Yannick , Feumo Feusso, H M , Mbosso Teinkela, Jean E , Siwe-Noundou, Xavier , Wintjens, René T , Isaacs, Michelle , Hoppe, Heinrich C , Krause, Rui W M , Azébazé, Anatole G B , Vardamides, Juliette C
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/195014 , vital:45519 , xlink:href="https://doi.org/10.1016/j.sajb.2018.10.008"
- Description: Antiplasmodial, antitrypanosomal and anti-HIV-1 activities of crude extracts, fractions and some isolated compounds from two Cameroonian medicinal plants: Antrocaryon klaineanum Pierre (Anacardiaceae) and Diospyros conocarpa Gürke ex K. Schum. (Ebenaceae) were assessed. The phytochemical studies led to the isolation of eight compounds (1–8) from Diospyros conocarpa and six compounds (6, 9–13) from Antrocaryon klaineanum. These compounds were identified as mangiferolic acid (1), 3β, 22(S)-dihydroxycycloart-24E-en-26-oic acid (2), lupeol (3), aridanin (4), betulin (5), betulinic acid (6), bergenin (7), D-quercitol(8), entilin C(9), entilin A(10), antrocarine A(11), 7R,20(S)-dihydroxy-4,24(28)-ergostadien-3-one(12) and stigmasterol glucoside (13). The criteria for activity were set as follows: an IC50 value more than 10 μg/mL for crude extracts and more than 1 μg/mL for pure compounds. The hexane/ethyl acetate (1:1) fraction of A.klaineanum root bark (AKERF1) and the hexane/ethyl acetate (1:1) fraction of A.klaineanum trunk bark (AKETF1) presented the strongest antiplasmodial activities with IC50 values of 0.4 and 4.4 μg/mL, respectively. Aridanin (4) and antrocarine A(11), as well as the crude extract of D.conocarpa roots (EDCR), AKERF1 and AKETF1 showed moderate trypanocidal effects. The crude extract of A.klaineanum root bark (AKER) and AKETF1 exhibited attractive activities on HIV-1 integrase with IC50 values of 1.96 and 24.04 μg/mL, respectively. The results provide baseline information on the use of A.klaineanum and D.conocarpa extracts, as well as certain components, as sources of new antiplasmodial, antitrypanosomal and anti-HIV drugs.
- Full Text:
- Date Issued: 2019
- Authors: Fouokeng, Yannick , Feumo Feusso, H M , Mbosso Teinkela, Jean E , Siwe-Noundou, Xavier , Wintjens, René T , Isaacs, Michelle , Hoppe, Heinrich C , Krause, Rui W M , Azébazé, Anatole G B , Vardamides, Juliette C
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/195014 , vital:45519 , xlink:href="https://doi.org/10.1016/j.sajb.2018.10.008"
- Description: Antiplasmodial, antitrypanosomal and anti-HIV-1 activities of crude extracts, fractions and some isolated compounds from two Cameroonian medicinal plants: Antrocaryon klaineanum Pierre (Anacardiaceae) and Diospyros conocarpa Gürke ex K. Schum. (Ebenaceae) were assessed. The phytochemical studies led to the isolation of eight compounds (1–8) from Diospyros conocarpa and six compounds (6, 9–13) from Antrocaryon klaineanum. These compounds were identified as mangiferolic acid (1), 3β, 22(S)-dihydroxycycloart-24E-en-26-oic acid (2), lupeol (3), aridanin (4), betulin (5), betulinic acid (6), bergenin (7), D-quercitol(8), entilin C(9), entilin A(10), antrocarine A(11), 7R,20(S)-dihydroxy-4,24(28)-ergostadien-3-one(12) and stigmasterol glucoside (13). The criteria for activity were set as follows: an IC50 value more than 10 μg/mL for crude extracts and more than 1 μg/mL for pure compounds. The hexane/ethyl acetate (1:1) fraction of A.klaineanum root bark (AKERF1) and the hexane/ethyl acetate (1:1) fraction of A.klaineanum trunk bark (AKETF1) presented the strongest antiplasmodial activities with IC50 values of 0.4 and 4.4 μg/mL, respectively. Aridanin (4) and antrocarine A(11), as well as the crude extract of D.conocarpa roots (EDCR), AKERF1 and AKETF1 showed moderate trypanocidal effects. The crude extract of A.klaineanum root bark (AKER) and AKETF1 exhibited attractive activities on HIV-1 integrase with IC50 values of 1.96 and 24.04 μg/mL, respectively. The results provide baseline information on the use of A.klaineanum and D.conocarpa extracts, as well as certain components, as sources of new antiplasmodial, antitrypanosomal and anti-HIV drugs.
- Full Text:
- Date Issued: 2019
Inhibition of aluminium corrosion using benzothiazole and its phthalocyanine derivative
- Nnaji, Nnaemeka, Nwaji, Njemuwa, Fomo, Gertrude, Mack, John, Nyokong, Tebello
- Authors: Nnaji, Nnaemeka , Nwaji, Njemuwa , Fomo, Gertrude , Mack, John , Nyokong, Tebello
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186949 , vital:44550 , xlink:href="https://doi.org/10.1007/s12678-019-00538-1"
- Description: Cyclic voltammetry and potentiodynamic polarization techniques were used to study the effects of 4-[4-(1,3-benzothiazol2yl)phenoxy] phthalonitrile (BT) and tetrakis[(benzo[d]thiazol-2ylphenoxy) phthalocyaninato] gallium(III)chloride (ClGaBTPc) as aluminium corrosion inhibitors in 1.0 M hydrochloric acid. The presence of the inhibitors in the concentration range of 2 to 10 μM was found to retard the aluminium corrosion process such that the inhibition efficiency was found to range from 28.2 to 76.1% for BT and from 71.5 to 82.7% for ClGaBTPc. The latter was a better inhibitor. Scanning electron microscopy and energy-dispersive X-ray measurements reveal effective metal surface protection by the inhibitors, most probably by shielding it from the corrosion attacks of Cl− from the acid. The calculated quantum chemical parameters agreed with experimental results.
- Full Text:
- Date Issued: 2019
- Authors: Nnaji, Nnaemeka , Nwaji, Njemuwa , Fomo, Gertrude , Mack, John , Nyokong, Tebello
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186949 , vital:44550 , xlink:href="https://doi.org/10.1007/s12678-019-00538-1"
- Description: Cyclic voltammetry and potentiodynamic polarization techniques were used to study the effects of 4-[4-(1,3-benzothiazol2yl)phenoxy] phthalonitrile (BT) and tetrakis[(benzo[d]thiazol-2ylphenoxy) phthalocyaninato] gallium(III)chloride (ClGaBTPc) as aluminium corrosion inhibitors in 1.0 M hydrochloric acid. The presence of the inhibitors in the concentration range of 2 to 10 μM was found to retard the aluminium corrosion process such that the inhibition efficiency was found to range from 28.2 to 76.1% for BT and from 71.5 to 82.7% for ClGaBTPc. The latter was a better inhibitor. Scanning electron microscopy and energy-dispersive X-ray measurements reveal effective metal surface protection by the inhibitors, most probably by shielding it from the corrosion attacks of Cl− from the acid. The calculated quantum chemical parameters agreed with experimental results.
- Full Text:
- Date Issued: 2019
Interactions between two biological control agents and their target weed: a beetle, a bug and a cactus weed
- Mnqeta, Zezethu, Paterson, Iain D
- Authors: Mnqeta, Zezethu , Paterson, Iain D
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/417475 , vital:71456 , xlink:href="https://doi.org/10.1080/09583157.2019.1631960"
- Description: Pereskia aculeata Miller (Cactaceae) is an invasive alien shrub introduced into South Africa from Brazil. The leaf-feeding beetle, Phenrica guerini Bechyne (Chrysomelidae), was released as a biological control agent in South Africa in 1991 followed by the stem-wilting bug, Catorhintha schaffneri Brailovsky and Garcia (Coreidae), in 2014. This study investigated the interactions between the two agents under laboratory conditions. Potted plants were exposed to one of four treatments: control (no agents), P. guerini only, C. schaffneri only and both species together. Four densities, ranging from 2 to 12 insects per plant were used. Cathorhitha schaffneri alone at low to moderate densities resulted in the same reduction in number of leaves and shoot length as when combine with P. guerini. At the highest density, C. schaffneri reduced the number of leaves significantly more than any treatment. Mortality of P. guerini was significantly higher than C. schaffneri at the highest density when in combination. The antagonistic interaction between P. guerini and C. schaffneri suggests that these agents should not be released together because this would impact negatively on the overall biocontrol programme against P. aculeata. It is recommended that C. schaffneri should be released at sites where P. guerini is not present. Extrapolation of laboratory-based studies into the field is often challenging, so mass-rearing and releases of P. guerini should continue until there is convincing proof that C. schaffneri alone is more effective than P. guerini in the field.
- Full Text:
- Date Issued: 2019
- Authors: Mnqeta, Zezethu , Paterson, Iain D
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/417475 , vital:71456 , xlink:href="https://doi.org/10.1080/09583157.2019.1631960"
- Description: Pereskia aculeata Miller (Cactaceae) is an invasive alien shrub introduced into South Africa from Brazil. The leaf-feeding beetle, Phenrica guerini Bechyne (Chrysomelidae), was released as a biological control agent in South Africa in 1991 followed by the stem-wilting bug, Catorhintha schaffneri Brailovsky and Garcia (Coreidae), in 2014. This study investigated the interactions between the two agents under laboratory conditions. Potted plants were exposed to one of four treatments: control (no agents), P. guerini only, C. schaffneri only and both species together. Four densities, ranging from 2 to 12 insects per plant were used. Cathorhitha schaffneri alone at low to moderate densities resulted in the same reduction in number of leaves and shoot length as when combine with P. guerini. At the highest density, C. schaffneri reduced the number of leaves significantly more than any treatment. Mortality of P. guerini was significantly higher than C. schaffneri at the highest density when in combination. The antagonistic interaction between P. guerini and C. schaffneri suggests that these agents should not be released together because this would impact negatively on the overall biocontrol programme against P. aculeata. It is recommended that C. schaffneri should be released at sites where P. guerini is not present. Extrapolation of laboratory-based studies into the field is often challenging, so mass-rearing and releases of P. guerini should continue until there is convincing proof that C. schaffneri alone is more effective than P. guerini in the field.
- Full Text:
- Date Issued: 2019
Investigation of novel substituted zinc and aluminium phthalocyanines for photodynamic therapy of epithelial breast cancer
- Mohammed, Imadalulla, Oluwole, David O, Nemakal, Majunatha, Sannegowda, Lokesh K, Nyokong, Tebello
- Authors: Mohammed, Imadalulla , Oluwole, David O , Nemakal, Majunatha , Sannegowda, Lokesh K , Nyokong, Tebello
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186824 , vital:44537 , xlink:href="https://doi.org/10.1016/j.dyepig.2019.107592"
- Description: A series of phthalonitrile ligands were synthesized by nucleophilic substitution reaction using the hydroxyl or sulfanyl group precursors and the nitro moiety of the nitrophthalonitrile to yield corresponding oxy or sulfanyl bridged ligands. These ligands were subsequently subjected to cyclocondensation reaction with diamagnetic metal ions like zinc and aluminium to afford symmetrically substituted zinc and aluminium phthalocyanine (Pc) complexes and polymers. The ligands and Pc complexes were characterized by 1 H nuclear magnetic resonance, fourier transform infrared, ultraviolet visible and mass spectrometric techniques. Additionally, thermal gravimetric, and elemental analyzer were used for characterization of the Pc complexes. The photophysical and photochemical behaviour of the Pc complexes were investigated in dimethyl sulfoxide. Additionally, the complexes were tested against epithelial breast cancer cells for photodynamic therapy (PDT) effect. The substituted ZnPc complexes afforded higher singlet oxygen quantum yields as compared to the AlPc analogue. All the complexes showed innocuous invitro dark cytotoxicity and moderate PDT effect.
- Full Text:
- Date Issued: 2019
- Authors: Mohammed, Imadalulla , Oluwole, David O , Nemakal, Majunatha , Sannegowda, Lokesh K , Nyokong, Tebello
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186824 , vital:44537 , xlink:href="https://doi.org/10.1016/j.dyepig.2019.107592"
- Description: A series of phthalonitrile ligands were synthesized by nucleophilic substitution reaction using the hydroxyl or sulfanyl group precursors and the nitro moiety of the nitrophthalonitrile to yield corresponding oxy or sulfanyl bridged ligands. These ligands were subsequently subjected to cyclocondensation reaction with diamagnetic metal ions like zinc and aluminium to afford symmetrically substituted zinc and aluminium phthalocyanine (Pc) complexes and polymers. The ligands and Pc complexes were characterized by 1 H nuclear magnetic resonance, fourier transform infrared, ultraviolet visible and mass spectrometric techniques. Additionally, thermal gravimetric, and elemental analyzer were used for characterization of the Pc complexes. The photophysical and photochemical behaviour of the Pc complexes were investigated in dimethyl sulfoxide. Additionally, the complexes were tested against epithelial breast cancer cells for photodynamic therapy (PDT) effect. The substituted ZnPc complexes afforded higher singlet oxygen quantum yields as compared to the AlPc analogue. All the complexes showed innocuous invitro dark cytotoxicity and moderate PDT effect.
- Full Text:
- Date Issued: 2019
Landscape, memory and learning to change in changing worlds: Contemplating intergenerational learning and traditional knowledge practices within social-ecological landscapes of change
- O'Donoghue, Rob B, Sandoval-Rivera, Juan Carlos, Payyappallimana, Unnikrishnan
- Authors: O'Donoghue, Rob B , Sandoval-Rivera, Juan Carlos , Payyappallimana, Unnikrishnan
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/388061 , vital:68304 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/187218"
- Description: The core paper and collection of short papers from Mexico, Africa, India and Sweden that make up this study on social-ecological landscapes developed as a South–South collaboration that was extended to include a case in the North. Our concern was to explore how situated, intergenerational knowledge commonly takes a back seat to the conceptual propositions that the environmental sciences have developed around matters of concern like biodiversity loss. In this way, scientific propositions have become the conceptual capital for informing future sustainability through Education for Sustainable Development (ESD). In response to this, a more situated turn has developed to engage both intergenerational practices and the institutional sciences, but the playing fields are seldom level and deliberations are often rife with misunderstandings.
- Full Text:
- Date Issued: 2019
- Authors: O'Donoghue, Rob B , Sandoval-Rivera, Juan Carlos , Payyappallimana, Unnikrishnan
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/388061 , vital:68304 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/187218"
- Description: The core paper and collection of short papers from Mexico, Africa, India and Sweden that make up this study on social-ecological landscapes developed as a South–South collaboration that was extended to include a case in the North. Our concern was to explore how situated, intergenerational knowledge commonly takes a back seat to the conceptual propositions that the environmental sciences have developed around matters of concern like biodiversity loss. In this way, scientific propositions have become the conceptual capital for informing future sustainability through Education for Sustainable Development (ESD). In response to this, a more situated turn has developed to engage both intergenerational practices and the institutional sciences, but the playing fields are seldom level and deliberations are often rife with misunderstandings.
- Full Text:
- Date Issued: 2019