https://commons.ufh.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 Identification of novel compounds against Plasmodium falciparum Cytochrome bc1 Complex inhibiting the trans-membrane electron transfer pathway: an In Silico study https://commons.ufh.ac.za/vital/access/manager/Repository/vital:65774 Wed 26 Jul 2023 09:16:33 SAST ]]> An in-silico study of the type II NADH: Quinone Oxidoreductase (ndh2). A new anti-malaria drug target https://commons.ufh.ac.za/vital/access/manager/Repository/vital:65767 Wed 26 Jul 2023 09:09:34 SAST ]]> Application of computer-aided drug design for identification of P. falciparum inhibitors https://commons.ufh.ac.za/vital/access/manager/Repository/vital:45265 Wed 24 Nov 2021 15:28:04 SAST ]]> The characterization of GTP Cyclohydrolase I and 6-Pyruvoyl Tetrahydropterin Synthase enzymes as potential anti-malarial drug targets https://commons.ufh.ac.za/vital/access/manager/Repository/vital:50127 Wed 20 Jul 2022 10:18:38 SAST ]]> Synthesis, characterisation and evaluation of ferrocene-containing Novobiocin analogues for anticancer and antiplasmodial activity through inhibition of Hsp90 https://commons.ufh.ac.za/vital/access/manager/Repository/vital:28690 Wed 19 Apr 2023 13:28:11 SAST ]]> Investigating assay formats for screening malaria Hsp90-Hop interaction inhibitors https://commons.ufh.ac.za/vital/access/manager/Repository/vital:28395 Wed 12 May 2021 23:59:53 SAST ]]> A novel, improved throughput bioassay for determining the delative speed of antimalarial drug action using fluorescent vitality probes https://commons.ufh.ac.za/vital/access/manager/Repository/vital:37810 Wed 12 May 2021 19:28:59 SAST ]]> Synthesis, characterisation and biological activity of 2-(methylthiomethyl)anilines, 2-(methylthio)anilines, their Schiff-base derivatives and metal(II) (Co, Ni, Cu) complexes https://commons.ufh.ac.za/vital/access/manager/Repository/vital:4562 Co(II) > Ni(II). The Schiff-base derivatives were prepared from the ligands and para-methoxysalicylaldehyde and their Cu(II) complexes were synthesized in order to determine their biological activity. The Schiff-base ligands were found to be less active than their parent ligands. The Cu(II) complexes are not soluble in water, DMSO or DMF, as a result and could not be evaluated for their biological activity. Based on the good results from the antimicrobial evaluation, the antiplasmodial activity of some of the Co(II), Ni(II) and Cu(II) complexes of the thiomethylated ligands against Plasmodium falciparum (FCR-3) was determined. At 50 μM concentration level, the Cu(II) complexes show activity equal or better than the prophylactic chloroquine. The Cu(II) complexes with the methoxy-substituted demonstrated exceptional activity but their Co(II) and Ni(II) analogues did not show any activity. The cytotoxicity of the active Cu(II) complexes at 50 μM concentration was determined against the breast cancer cell line (MDA-MB-231). The compounds destroyed the cancer cell in the range of 28–40%, thus showing their preferred activity against the parasitic cell instead of the cancer cell. The selectivity demonstrated by these compounds have shown them to be potential antimalarial agents and this could be further investigated.]]> Wed 12 May 2021 17:24:20 SAST ]]> Antimalarial activity of quinoline thiosemicarbazones: synthesis and antiplasmodial evaluation https://commons.ufh.ac.za/vital/access/manager/Repository/vital:56841 Tue 25 Oct 2022 14:23:47 SAST ]]> Antimalarial secondary metabolites from Morinda lucida https://commons.ufh.ac.za/vital/access/manager/Repository/vital:25535 Thu 13 May 2021 07:33:28 SAST ]]> Structural analysis of prodomain inhibition of cysteine proteases in plasmodium species https://commons.ufh.ac.za/vital/access/manager/Repository/vital:4021 Thu 13 May 2021 07:22:37 SAST ]]> In silico study of Plasmodium 1-deoxy-dxylulose 5-phosphate reductoisomerase (DXR) for identification of novel inhibitors from SANCDB https://commons.ufh.ac.za/vital/access/manager/Repository/vital:28523 Thu 13 May 2021 07:20:26 SAST ]]> Synthesis of silver nanoparticles and their role against human and Plasmodium falciparum leucine aminopeptidase https://commons.ufh.ac.za/vital/access/manager/Repository/vital:4150 Thu 13 May 2021 06:17:59 SAST ]]> Marine anti-malarial isonitriles : a synthetic and computational study https://commons.ufh.ac.za/vital/access/manager/Repository/vital:4398 Thu 13 May 2021 04:46:16 SAST ]]> The interaction of silver nanoparticles with triosephosphate isomerase from human and malarial parasite (Plasmodium falciparum) : a comparative study https://commons.ufh.ac.za/vital/access/manager/Repository/vital:4169 Thu 13 May 2021 04:27:15 SAST ]]> The isolation, quantification and synthetic modification of antiplasmodial natural products from sargassum heterophyllum https://commons.ufh.ac.za/vital/access/manager/Repository/vital:3871 Thu 13 May 2021 03:06:22 SAST ]]> Synthesis of silver nanoparticles and their role against a thiazolekinase enzyme from Plasmodium falciparum https://commons.ufh.ac.za/vital/access/manager/Repository/vital:4168 Thu 13 May 2021 02:23:44 SAST ]]> Malarial drug targets cysteine proteases as hemoglobinases https://commons.ufh.ac.za/vital/access/manager/Repository/vital:4005 Thu 13 May 2021 02:15:53 SAST ]]> Synthesis, characterisation and evaluation of benzoxaborole-based hybrids as antiplasmodial agents https://commons.ufh.ac.za/vital/access/manager/Repository/vital:27456 Thu 13 Apr 2023 09:16:21 SAST ]]> A medicinal chemistry study in nitrogen containing heterocycles https://commons.ufh.ac.za/vital/access/manager/Repository/vital:28430 Thu 09 Mar 2023 13:07:21 SAST ]]> Exploring para-thiophenols to expand the SAR of antimalarial 3-indolylethanones https://commons.ufh.ac.za/vital/access/manager/Repository/vital:28428 Thu 09 Mar 2023 11:57:44 SAST ]]> Development and optimisation of a novel Plasmodium falciparum Hsp90-Hop interaction assay https://commons.ufh.ac.za/vital/access/manager/Repository/vital:28216 Thu 01 Jun 2023 09:58:06 SAST ]]> Synthesis and biolgical screening of potential plasmodium falciparum DXR inhibitors https://commons.ufh.ac.za/vital/access/manager/Repository/vital:28060 Fri 15 Oct 2021 11:35:53 SAST ]]> Studies towards the development of novel antimalarial agents https://commons.ufh.ac.za/vital/access/manager/Repository/vital:26596 Fri 09 Jun 2023 15:34:31 SAST ]]>