https://commons.ufh.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://commons.ufh.ac.za/vital/access/manager/Repository/vital:62543 Wed 15 Mar 2023 11:50:40 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:11275 0.05). The newer fluoroquinolones are a possible alternative treatment option for S. maltophilia infections in this environment but further studies and clinical investigations are needed to determine the in vivo efficacy of these drugs.]]> Wed 12 May 2021 22:57:08 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:11256 Wed 12 May 2021 22:23:09 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:11247 0.05). Qualitative phytochemical analysis confirmed the presence of alkaloids, saponins, steroids, tannins and flavonoids in the methanol, acetone,ethanol and ethyl acetate extracts. The results demonstrate that H. africana may contain compounds with therapeutic potentials which can be lead molecules for semi-synthesis of new drugs.]]> Wed 12 May 2021 19:43:31 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:4043 Wed 12 May 2021 19:40:59 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:11242 Wed 12 May 2021 19:18:56 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:20807 Wed 12 May 2021 17:46:03 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:11243 Wed 12 May 2021 16:46:52 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:38540 Wed 12 May 2021 16:46:03 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:30026 Wed 12 May 2021 16:31:56 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:11257 Wed 12 May 2021 16:28:51 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:31232 Wed 12 May 2021 16:19:18 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:3891 Wed 12 May 2021 15:49:42 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:40690 Wed 12 May 2021 15:07:39 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:41484 Wed 12 May 2021 14:28:57 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:45048 Thu 19 May 2022 12:17:43 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:10126 Thu 13 May 2021 06:18:25 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:11240 0.05); and efficient bactericidal activity (100% bacterial cells killed) at 1/2MIC and 4xMIC over different time intervals, 36-72hrs and 18-72hrs respectively. The appearance of bands on the thin layer chromatography (TLC) chromatogram spotted with the chloroform extracts of PH and CRT; and developed with hexane: ethyl acetate: acetic acid (HEA) and methanol: acetic acid: water (MAAW) solvent systems indicated the presence of compounds. Purification of the compounds contained in these extracts over silica gel column yielded numerous fractions which were evaluated for antibacterial activity and purity. PHF5 was the most active fraction with a mean MIC50 value of 1.25mg/mL. Volatile compounds belonging to different known chemical families in honey were identified in all the active fractions obtained from PH. Conversely, only four compounds were identified in the active fractions obtained from CRT hence the non volatile constituents could be of prime relevance with respect to antibacterial activity of this honey. Of novelty was the presence of thiophene and N-methyl-D3-azirdine compounds, essential precursors used for the synthesis of natural products and pharmaceuticals with vital biomedical properties. Linalool demonstrated potent inhibitory (MIC95, 0.002- 0.0313mg/mL) and bactericidal activity (0.0039-0.313mg/mL) against the test isolates. On the other hand, a significant difference was recorded (P < 0.05) in comparing the activity of linalool compound to the fractions. PH could serve as a good economic source of bioactive compounds which could be employed as template for the synthesis of novel anti-H. pylori drugs. However, further studies are needed to determine the non volatile active ingredients in PH and CRT as well as toxicological testing]]> Thu 13 May 2021 05:55:33 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:11260 Thu 13 May 2021 03:38:41 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:11259 Thu 13 May 2021 03:10:48 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:11261 0.05) in the potency of the xii four extracts (acetone, methanol, ethanol and ethyl acetate) and antibiotic (ciprofloxacin) on the different bacterial strains tested, likewise the crude extract and the fractions. No compound was detected by GC-MS whereas numerous peaks were identified by HPLC implying that the active compounds in this plant are non volatile. We could not identify the compounds thereby proposing further studies using Nuclear magnetic resonance to identify the compounds. The study revealed that the acetone extract of C. molle was the most active against all the test organisms and therefore justifies the use of this plant in traditional medicine.]]> Thu 13 May 2021 01:14:11 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:45661 Thu 13 Jan 2022 16:12:10 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:54395 Fri 15 Mar 2024 12:10:52 SAST ]]>