https://commons.ufh.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://commons.ufh.ac.za/vital/access/manager/Repository/vital:30542 Wed 12 May 2021 19:54:48 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:10432 Wed 12 May 2021 18:34:43 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:4323 Wed 12 May 2021 18:24:41 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:10440 Wed 12 May 2021 17:10:11 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:4497 2500 μg/mL) and did not show any activity against the yeast, C. albicans. The second set of compounds consisted of the silver(I) complexes containing 2-hydroxymethyl-N-alkylimidazoles. The complexes displayed a broad spectrum antimicrobial activity towards the microorganisms that were tested and their activity [E. coli (MIC = 5-40 μg/mL), S. aureus (MIC = 20-80 μg/mL), Bacillus subtilis subsp. spizizenii (MIC = 5-40 μg/mL) and C. albicans (MIC = 40-80 μg/mL)] increased with the alkyl chain length of the 2-hydroxymethyl-N-alkylimidazole. The third set of compounds consisted of the vinylimidazoles containing the vinyl group either at the 1-position or at the 4- or 5- position. The imidazoles with the vinyl group at the 4- or 5-position contained the alkyl group (decyl) at the 1-position. For the fabrication of the antimicrobial nanofibers, the first two sets of imidazole derivatives (2-substituted N-alkylimidazoles and silver(I) complexes) were incorporated into electrospun nylon 6 nanofibers while the third set (2-substituted vinylimidazoles) was immobilized onto electrospun nylon 6 nanofibers employing the graft polymerization method. The antimicrobial nylon nanofibers were characterized by IR spectroscopy and SEM-EDAX (EDS). The electrospun nylon 6 nanofibers incorporated with 2-substituted N-alkylimidazoles displayed moderate to excellent levels of growth reduction against S. aureus (73.2-99.8 percent). For the electrospun nylon 6 nanofibers incorporated with silver(I) complexes, the levels of growth reduction were >99.99 percent, after the antimicrobial activity evaluation using the shake flask method. Furthermore, the grafted electrospun nylon 6 nanofibers showed excellent levels of growth reduction for E. coli (99.94-99.99 percent) and S. aureus (99.93-99.99 percent). The reusability results indicated that the grafted electrospun nylon 6 nanofibers maintained the antibacterial activity until the third cycle of useage. The cytotoxicity studies showed that grafted electrospun nylon 6 nanofibers possess lower cytotoxic effects on Chang liver cells with IC50 values in the range 23.48-26.81 μg/mL. The thesis demonstrated that the development of antimicrobial electrospun nanofibers, with potential for the eradication of pathogenic microoganisms in water, could be accomplished by incorporation as well as immobilization strategies.]]> Wed 12 May 2021 16:49:28 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:4294 Thu 13 May 2021 04:10:37 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:10431 Thu 13 May 2021 03:29:24 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:30937 Thu 13 May 2021 00:33:13 SAST ]]> https://commons.ufh.ac.za/vital/access/manager/Repository/vital:69851 Fri 15 Mar 2024 12:52:01 SAST ]]>